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Attia Mohammed Sabri MS Division of Neurosurgery, St. Michael's Hospital, 30 Bond Street, Toronto, ON, M5B 1W8, - - 2015
Subarachnoid hemorrhage (SAH) remains one of the most morbid subtypes of stroke around the world and has been the focus of hemorrhagic stroke research for longer than five decades. Animal models have been instrumental in shaping the progress and advancement of SAH research, particularly models that allow for transgenic manipulation. ...
Osier Nicole N University of Pittsburgh School of Nursing, Department of Acute & Tertiary Care , 201 Hill Building , 3434 Fifth Avenue , Pittsburgh, Pennsylvania, United States , 15260 , University of Pittsburgh, Safar Center for Resuscitation, Pittsburgh, Pennsylvania, United States ; - - 2014
The purpose of this review is to survey the use of experimental animal models for studying the chronic histopathological and behavioral consequences of traumatic brain injury (TBI). The strategies employed to study the long-term consequences of TBI are described, along with a summary of the evidence available to date from ...
Li Ke - - 2014
Multiobjective evolutionary algorithm based on decomposition (MOEA/D), which bridges the traditional optimization techniques and population-based methods, has become an increasingly popular framework for evolutionary multiobjective optimization. It decomposes a multiobjective optimization problem (MOP) into a number of optimization subproblems. Each subproblem is handled by an agent in a collaborative manner. ...
Chen Zhihuan Z School of Hydropower and Information Engineering, Huazhong University of Science and Technology, 430074 Wuhan, - - 2014
A hydraulic turbine regulating system (HTRS) is one of the most important components of hydropower plant, which plays a key role in maintaining safety, stability and economical operation of hydro-electrical installations. At present, the conventional PID controller is widely applied in the HTRS system for its practicability and robustness, and ...
Jiang Siwei - - 2014
To find diversified solutions converging to true Pareto fronts (PFs), hypervolume (HV) indicator-based algorithms have been established as effective approaches in multiobjective evolutionary algorithms (MOEAs). However, the bottleneck of HV indicator-based MOEAs is the high time complexity for measuring the exact HV contributions of different solutions. To cope with this ...
Cai Yongli Y Department of Mathematics, Sun Yat-Sen University, Guangzhou 510275, China. - - 2014
In this article, we study the rich dynamics of a diffusive predator-prey system with Allee effects in the prey growth. Our model assumes a prey-dependent Holling type-II functional response and a density dependent death rate for predator. We investigate the dissipation and persistence property, the stability of nonnegative and positive ...
Luna Jose Maria - - 2014
This paper proposes a novel grammar-guided genetic programming algorithm for subgroup discovery. This algorithm, called comprehensible grammar-based algorithm for subgroup discovery (CGBA-SD), combines the requirements of discovering comprehensible rules with the ability to mine expressive and flexible solutions owing to the use of a context-free grammar. Each rule is represented ...
Gao Daozhou D Francis I. Proctor Foundation for Research in Ophthalmology University of California, San Francisco San Francisco, CA 94143, - - 2014
Based on the classical Ross-Macdonald model, in this paper we propose a periodic malaria model to incorporate the effects of temporal and spatial heterogeneity on disease transmission. The temporal heterogeneity is described by assuming that some model coefficients are time-periodic, while the spatial heterogeneity is modeled by using a multi-patch ...
Nazif-Munoz José Ignacio JI Department of Sociology, McGill University, Montreal, - - 2014
The objective of the current study is to determine to what extent the reduction of Chile's traffic fatalities and injuries during 2000-2012 was related to the police traffic enforcement increment registered after the introduction of its 2005 traffic law reform. A unique dataset with assembled information from public institutions and ...
Dahlström O O Department of Behavioural Sciences and Learning, Linköping University, Linköping, - - 2014
The organization of sports at the national level has seldom been included in scientific discussions of sports injury prevention. The aim of this study was to develop a model for organization of sports that supports prevention of overuse injuries. The quality function deployment technique was applied in seminars over a ...
Grewal Navneet N Department of Pedodontics and Preventive Dentistry, Punjab Government Dental College and Hospital, Amritsar, Punjab, - - 2014
Prevention of orofacial injuries is one of the biggest pre-occupations in sports dentistry. The custom-fitted mouthguard is considered the best choice for fit and protection when compared to over-the-counter commercial mouthguards. However, cost and time prohibit their mass production. It is therefore imperative to have an over-the-counter true mouth-formed mouthguard ...
Kalra Mayank M Laboratory for Alternative Energy Conversion (LAEC), School of Mechatronic Systems Engineering, Simon Fraser University, 250-13450 102nd Avenue, Surrey, BC, V3T 0A3, Canada, - - 2014
Therapeutic hypothermia is rapidly becoming an integral part of post-resuscitative care for post-cardiac arrest and neurotrauma patients. Despite the significant impact of thermoregulation on core temperature drop during rapid cooling, current mathematical models for thermoregulation have not been validated for hypothermic conditions. A geometrically accurate 3D model of an upper ...
Cosic Nela - - 2014
Although abbreviated surgery with planned reoperation (damage control surgery) is now widely used to manage major trauma patients, the procedure and its component interventions have not been evaluated in randomized controlled trials (RCTs). While some have suggested the need for such trials, they are unlikely to be conducted because of ...
Veliz-Cuba Alan A Department of Mathematics, University of Houston, Houston, TX, 77204-3008, USA, - - 2014
Models of biochemical networks are frequently complex and high-dimensional. Reduction methods that preserve important dynamical properties are therefore essential for their study. Interactions in biochemical networks are frequently modeled using Hill functions ([Formula: see text]). Reduced ODEs and Boolean approximations of such model networks have been studied extensively when the ...
Crisco Joseph J JJ Bioengineering Laboratory, Department of Orthopaedics, Warren Alpert Medical School of Brown University, and Rhode Island Hospital, Providence, - - 2014
Girls' lacrosse is fundamentally a different sport than boys' lacrosse, and girls are not required to wear protective headgear. Recent epidemiological studies have found that stick checks are the leading cause of concussion injury in girls' lacrosse. The purpose of this study was to determine stick check speeds and estimate ...
Wang Hui H Key Laboratory of Bio-Based Material Science and Technology of the Ministry of Education, Northeast Forestry University, Harbin 150040, - - 2014
To develop new rosin-based wood preservatives with good antifungal activity, 24 rosin derivatives were synthesized, bioassay tested with Trametes versicolor and Gloeophyllum trabeum, and subjected to analysis of their quantitative structure-activity relationships (QSAR). A QSAR analysis using Ampac 9.2.1 and Codessa 2.7.16 software built two QSAR models of antifungal ratio ...
Toya Yoshihiro Y Department of Bioinformatic Engineering, Graduate School of Information Science and Technology, Osaka University, 1-5 Yamadaoka, Suita, Osaka, 565-0871, Japan; Advanced Low Carbon Technology Research and Development Program, Japan Science and Technology Agency (JST, - - 2014
Metabolic pathway modification based on the stoichiometric model has been an effective approach for enhancing microbial bio-production. The network of optimal pathways for "growth-associated" and "non-growth-associated" production can be designed from the flux variability (solution space). The present study introduces a new computational method (solution space design [SSDesign]) that visually ...
Zanith Caroline C CC Departamento de Ciências Naturais, Universidade Federal de São João del-Rei, São João del-Rei, MG, 36301-160, - - 2014
The continuum solvation models SMD and SM8 were developed using 2,346 solvation free energy values for 318 neutral molecules in 91 solvents as reference. However, no solvation data of neutral solutes in methanol was used in the parametrization, while only few solvation free energy values of solutes in dimethyl sulfoxide ...
Romps David M DM Department of Earth and Planetary Science, University of California, Berkeley, and Earth Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA. - - 2014
Lightning plays an important role in atmospheric chemistry and in the initiation of wildfires, but the impact of global warming on lightning rates is poorly constrained. Here we propose that the lightning flash rate is proportional to the convective available potential energy (CAPE) times the precipitation rate. Using observations, the ...
Zhao Shanshan S Department of Civil Engineering and Nebraska Transportation Center, University of Nebraska-Lincoln, 330 Whittier Research Center, Lincoln, NE 68583-0851, United - - 2014
The objectives of this research were to: (1) identify a more suitable model for modeling injury severity of motor vehicle drivers involved in train-motor vehicle crashes at highway-rail grade crossings from among three commonly used injury severity models and (2) to investigate factors associated with injury severity levels of motor ...
Pouzols Federico Montesino FM Finnish Centre of Excellence in Metapopulation Biology, Department of Biosciences, Biocenter 3, University of Helsinki, PO Box 65 (Viikinkaari 1), FI-00014 Helsinki, - - 2014
Protected areas are one of the main tools for halting the continuing global biodiversity crisis caused by habitat loss, fragmentation and other anthropogenic pressures. According to the Aichi Biodiversity Target 11 adopted by the Convention on Biological Diversity, the protected area network should be expanded to at least 17% of ...
Gawthrop Peter J PJ Systems Biology Laboratory , Melbourne School of Engineering, University of Melbourne , Victoria 3010, - - 2014
Thermodynamic aspects of chemical reactions have a long history in the physical chemistry literature. In particular, biochemical cycles require a source of energy to function. However, although fundamental, the role of chemical potential and Gibb's free energy in the analysis of biochemical systems is often overlooked leading to models which ...
Sakharova L V LV Rostov State University of Economics, Department of Fundamental and Applied Mathematics , Rostov-on-Don, - - 2014
The mathematical model describing the stationary natural pH-gradient arising under the action of an electric field in an aqueous solution of ampholytes is constructed and investigated. The model is a part of a more general model of the isoelectrofocusing process. Investigation is based on the approximation of a weak solution ...
Held Alexander A Freiburger Materialforschungszentrum, Albert-Ludwigs-Universität Freiburg, Stefan-Meier-Straße 21, D-79104 Freiburg, - - 2014
We present a continuum solvent model (CSM) with a smooth cavity for the application in grid-based electronic structure methods. The cavity is identified with the inherently smooth distribution function of a binary mixture at infinite dilution. We obtain a cavity model based on atomic van der Waals radii and one ...
Stockdale Gregory G Department of Statistical Sciences, Projects Clinical Platform, R&D, GlaxoSmithKline, King of Prussia, Pennsylvania, - - 2014
Comparing higher order structure (HOS) in therapeutic proteins is a significant challenge. Previously, we showed that changes in solution conditions produced detectable changes in the second-derivative amide I Fourier transform infrared (FTIR) spectra for a variety of model proteins. Those comparisons utilized vector-based approaches, such as spectral overlap and spectral ...
Eid Hani O HO Department of Surgery, College of Medicine and Health Sciences, UAE University, PO Box 17666, Al Ain, - - 2014
Pedestrians are vulnerable road users who are at risk of injuries and death on the roads. We aimed to define factors affecting pedestrian injuries-related deaths worldwide and to give recommendations regarding their prevention priorities. Data on pedestrian injuries-related deaths for years 2007 and 2010 were retrieved from the WHO global ...
Stary Tomas - - 2014
The modern Markov chain models of ionic channels in excitable membranes are numerically stiff. The popular numerical methods for these models require very small time steps to ensure stability. Our objective is to formulate and test two methods addressing this issue, so that the timestep can be chosen based on ...
Wang Wei W Department of Neurosurgery, Renmin Hospital of Wuhan University, Wuhan, 430060, People's Republic of - - 2014
Intracerebral hemorrhagic transformation (HT) is well recognized as a common cause of hemorrhage in patients with ischemic stroke. HT after acute ischemic stroke contributes to early mortality and adversely affects functional recovery. The risk of HT is especially high when patients receive thrombolytic reperfusion therapy with tissue plasminogen activator, the ...
Wirth Roland R Institut für Kernphysik, Technische Universität Darmstadt, Schlossgartenstraße 2, 64289 Darmstadt, - - 2014
We present the first ab initio calculations for p-shell single-Λ hypernuclei. For the solution of the many-baryon problem, we develop two variants of the no-core shell model with explicit Λ and Σ^{+},Σ^{0},Σ^{-} hyperons including Λ-Σ conversion, optionally supplemented by a similarity renormalization group transformation to accelerate model-space convergence. In addition to ...
Hirose Satoshi S CiNet, National Institute of Information and Communications Technology, CiNet Bldg., 1-4 Yamadaoka, Suita, Osaka 565-0871, Japan. Electronic address: - - 2014
Recent functional magnetic resonance imaging (fMRI) decoding techniques allow us to predict the contents of sensory and motor events or participants' mental states from multi-voxel patterns of fMRI signals. Sparse logistic regression (SLR) is a useful pattern classification algorithm that has the advantage of being able to automatically select voxels ...
Awoukeng Goumtcha Aristide A Institut de Recherche sur les Transports, l'Energie, la Société (IRTES - M3M), Université de Technologie de Belfort-Montbéliard UTBM, Belfort, Cedex, 90010, - - 2014
Injury mechanisms due to high speed dynamic loads, such as blasts, are not well understood. These research fields are widely investigated in the literature, both at the experimental and numerical levels, and try to answer questions about the safety and efficiency of protection devices or biomechanical traumas. At a numerical ...
Wang Hao H Department of Traditional Chinese Internal Medicine, China-Japan Friendship Hospital, Beijing 100029, P.R. - - 2014
The aim of this study was to establish a mouse model of vascular dementia (VaD) in order to overcome the shortcomings of rat models of VaD, which include high production costs, difficult surgery, surgical trauma and high mortality. In this study, repeated ischemia-reperfusion of the total bilateral carotid artery in ...
Yazidi Anis - - 2014
Stochastic point location (SPL) deals with the problem of a learning mechanism (LM) determining the optimal point on the line when the only input it receives are stochastic signals about the direction in which it should move. One can differentiate the SPL from the traditional class of optimization problems by ...
Zhong Fujin - - 2014
Conventional discriminant locality preserving projection (DLPP) is a dimensionality reduction technique based on manifold learning, which has demonstrated good performance in pattern recognition. However, because its objective function is based on the distance criterion using L2-norm, conventional DLPP is not robust to outliers which are present in many applications. This ...
Massucci Francesco Alessandro FA Departament d'Enginyeria Química, Universitat Rovira i Virgili, 43007 Tarragona, - - 2014
The mechanical properties of molecules are today captured by single molecule manipulation experiments, so that polymer features are tested at a nanometric scale. Yet devising mathematical models to get further insight beyond the commonly studied force-elongation relation is typically hard. Here we draw from techniques developed in the context of ...
Greschner Sebastian S Institut für Theoretische Physik, Leibniz Universität Hannover, Appelstrasse 2, DE-30167 Hannover, - - 2014
Recent experiments show that periodic modulations of cold atoms in optical lattices may be used to engineer and explore interesting models. We show that double modulation combining lattice shaking and modulated interactions allows for the engineering of a much broader class of lattice with correlated hopping, which we study for ...
Zimmerman Karen K a Amend , PO Box 38474 Dar es Salaam , - - 2014
Abstract OBJECTIVE Road traffic injuries (RTIs) are a major public health burden, especially in low and middle-income countries. There is limited data on RTIs in low volume, rural African settings. This study attempted to survey all individuals living in households within 200 meters of two low-volume rural roads in Tanzania ...
Vagal Achala S AS From the Department of Radiology (A.S.V., T.A.T.), Department of Neurology (P.K., J.P.B.), and Department of Internal Medicine (M.H.E.), University of Cincinnati Medical Center, OH; and Department of Public Health Sciences, Medical University of South Carolina, Charleston (S.D.Y.). - - 2014
Our objective was to use decision analytic modeling to compare 2 treatment strategies of intravenous recombinant tissue-type plasminogen activator (r-tPA) alone versus combined intravenous r-tPA/endovascular therapy in a subgroup of patients with large vessel (internal carotid artery terminus, M1, and M2) occlusion based on varying times to angiographic reperfusion and ...
Ram Yoav Y The Department of Molecular Biology and Ecology of Plants, The George S. Wise Faculty of Life Sciences, Tel-Aviv University, Tel-Aviv 69978, Israel. Electronic address: - - 2014
Fisher developed his geometric model to support the micro-mutationalism hypothesis which claims that small mutations are more likely to be beneficial and therefore to contribute to evolution and adaptation. While others have provided a general solution to the model using geometric approaches, we derive an equivalent general solution using a ...
Bonebrake Timothy C TC Department of Earth Sciences, School of Biological Sciences, University of Hong Kong, Pokfulam Road, Hong Kong SAR, Hong Kong - - 2014
Difficulty in characterizing the relationship between climatic variability and climate change vulnerability arises when we consider the multiple scales at which this variation occurs, be it temporal (from minute to annual) or spatial (from centimetres to kilometres). We studied populations of a single widely distributed butterfly species, Chlosyne lacinia, to ...
Wei Junying - - 2014
Evaluating the safety of traditional medicinal herbs and their major active constituents is critical for their widespread usage. Geniposide, a major active constituent with a defined structure from the traditional medicinal herb Gardenia jasminoides ELLIS fruit, exhibits remarkable anti-inflammatory, anti-apoptotic and antifibrotic properties and has been used in a variety ...
Clermont Gilles G Crisma Center, Departments of Critical Care Medicine, Mathematics, and Chemical Engineering, University of Pittsburgh, 200 Lothrop St, Pittsburgh, PA 16123. Electronic address: - - 2014
Biological systems present particular challengers to model for the purposes of formulating predictions of generating biological insight. These systems are typically multi-scale, complex, and empirical observations are often sparse and subject to variability and uncertainty. This manuscript will review some of these specific challenges and introduce current methods used by ...
Owens Katie H KH School of Pharmacy, University of Otago, Dunedin, New - - 2014
Paracetamol is one of the most common pharmaceutical agents taken in self-poisonings and may increase the prothrombin time (PT) through liver injury, and in overdose without hepatic injury by reducing functional factor VII [1-4]. PT is a measure of hepatic injury used to predict and monitor hepatotoxicity, reported as the ...
Meyer-Baese Anke A Department of Scientific Computing, Florida State University, - - 2014
The interpretation of phosphoproteomics data sets is crucial for generating hypotheses that guide therapeutic solutions, yet not many techniques have been applied to this type of analysis. This paper intends to give an overview about the two main standard techniques that can be applied to the analysis of these large ...
Wang Chen C a School of Transportation Engineering , Tongji University , 4800 Cao'an Road, Shanghai 201804 , China ., Phone: +86-18221148065 Email: - - 2014
ABSTRACT Objectives This study investigated factors correlated with the severity of injuries sustained by bicyclists in bicycle-motor vehicle crashes at unsignalized intersections to develop site-specific countermeasures and interventions to improve bicycle safety. Method Crash data were extracted from accident reports entered into the Kentucky State Police's Kentucky Collision Database in ...
Dorn Márcio M Federal University of Rio Grande do Sul, Institute of Informatics, Av. Bento Gonçalves 9500, 91501-970 Porto Alegre, RS, Brazil. Electronic address: - - 2014
A long standing problem in structural bioinformatics is to determine the three-dimensional (3-D) structure of a protein when only a sequence of amino acid residues is given. Many computational methodologies and algorithms have been proposed as a solution to the 3-D Protein Structure Prediction (3-D-PSP) problem. These methods can be ...
Pretz Christopher R CR Craig Hospital, Englewood CO; Traumatic Brain Injury National Data and Statistical Center, Englewood CO. Electronic address: - - 2014
To verify that iterative proportional fitting (IPF) or raking has the desired effect of aligning estimates and parameters so that researches have confidence in population projections when weighting the Traumatic Brian Injury (TBI) Model Systems National Database. Secondary data analysis using IPF. Inpatient rehabilitation. People age 16 and over with ...
Kong Guilan G Peking University, - - 2014
Peking University has several prestigious teaching hospitals in China. To make secondary use of massive medical data for research purposes, construction of a clinical data warehouse is imperative in Peking University. However, a big concern for clinical data warehouse construction is how to protect patient privacy. In this project, we ...
Spiriti Justin J Department of Computational and Systems Biology, University of Pittsburgh , Pittsburgh, Pennsylvania 15213, United - - 2014
Many commonly used coarse-grained models for proteins are based on simplified interaction sites and consequently may suffer from significant limitations, such as the inability to properly model protein secondary structure without the addition of restraints. Recent work on a benzene fluid (Lettieri S.; Zuckerman D. M.J. Comput. Chem.2012, 33, 268-275) ...
Díaz J I JI Instituto de Matemática Interdisciplinar and Dept. Mat. Aplicada , Universidad Complutense de Madrid , 28040 Madrid, - - 2014
We study a climatologically important interaction of two of the main components of the geophysical system by adding an energy balance model for the averaged atmospheric temperature as dynamic boundary condition to a diagnostic ocean model having an additional spatial dimension. In this work, we give deeper insight than previous ...
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