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Ruiz Luz M LM a Technologies for Water Management and Treatment Research Group , University of Granada , Granada , - - 2014
Five different wastewater COD fractionation methods were employed for simulating an experimental MBR wastewater treatment plant using WEST. The predictions of dynamic simulations using as input the data obtained according to each influent characterization methodology were compared with the results of the experimental system and differences between experimental and predicted ...
Henson Stephanie A SA National Oceanography Centre, European Way, Southampton SO14 3ZH, UK - - 2014
Sustained observations (SOs) have provided invaluable information on the ocean's biology and biogeochemistry for over 50 years. They continue to play a vital role in elucidating the functioning of the marine ecosystem, particularly in the light of ongoing climate change. Repeated, consistent observations have provided the opportunity to resolve temporal ...
Koerber Susanne S Freiburg University of - - 2014
The development of scientific thinking was assessed in 1,581 second, third, and fourth graders (8-, 9-, 10-year-olds) based on a conceptual model that posits developmental progression from naïve to more advanced conceptions. Using a 66-item scale, five components of scientific thinking were addressed, including experimental design, data interpretation, and understanding ...
Nguyen Hai H Department of Chemistry, ‡Laufer Center for Physical and Quantitative Biology and §Graduate Program in Biochemistry and Structural Biology, Stony Brook University , Stony Brook, New York 11794-5252, United - - 2014
The millisecond time scale needed for molecular dynamics simulations to approach the quantitative study of protein folding is not yet routine. One approach to extend the simulation time scale is to perform long simulations on specialized and expensive supercomputers such as Anton. Ideally, however, folding simulations would be more economical ...
Dankulchai Pittaya P Mount Vernon Cancer Centre, Northwood, United Kingdom; Division of Radiation Oncology, Department of Radiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand. Electronic address: - - 2014
To investigate the optimal distribution of sources using high dose rate brachytherapy to deliver a focal boost to a dominant lesion within the whole prostate gland based on multi-parametric magnetic resonance imaging (mpMRI). Sixteen patients with prostate cancer underwent mpMRI each of which demonstrated a dominant lesion. There were single ...
Zhang Ning N Department of Biomedical Engineering, Tianjin Key Lab of BME Measurement, Tianjin University, Tianjin, 300072, People's Republic of - - 2014
More than ten thousand coding variants are contained in each human genome; however, our knowledge of the way genetic variants underlie phenotypic differences is far from complete. Small insertions and deletions (indels) are one of the most common types of human genetic variants, and indels play a significant role in ...
Boroujerdian Amin Mirza AM Faculty of Civil & Environmental Engineering, Tarbiat Modares University, Tehran, Iran. Electronic address: - - 2014
Currently, high social and economic costs in addition to physical and mental consequences put road safety among most important issues. This paper aims at presenting a novel approach, capable of identifying the location as well as the length of high crash road segments. It focuses on the location of accidents ...
Chandra Siddharth - - 2014
The 1918-19 'Spanish' Influenza was the most devastating pandemic in recent history, with estimates of global mortality ranging from 20 to 50 million. The focal point of the pandemic was India, with an estimated death toll of between 10 and 20 million. We will characterize the pattern of spread, mortality, ...
Park Jungkap - - 2014
Multibody potentials accounting for cooperative effects of molecular interactions have shown better accuracy than typical pairwise potentials. The main challenge in the development of such potentials is to find relevant structural features that characterize the tightly folded proteins. Also, the side-chains of residues adopt several specific, staggered conformations, known as ...
Maidment Susannah C R SC Department of Earth Sciences, The Natural History Museum, Cromwell Road, London, SW7 5BD, UK, - - 2014
The exceptionally rare transition to quadrupedalism from bipedal ancestors occurred on three independent occasions in ornithischian dinosaurs. The possible driving forces behind these transitions remain elusive, but several hypotheses-including the development of dermal armour and the expansion of head size and cranial ornamentation-have been proposed to account for this major ...
Lamarque Pénélope P Laboratoire d'Ecologie Alpine, Unité Mixte de Recherche 5553, Centre National de la Recherche Scientifique, Université Joseph Fourier, BP 53, 38041 Grenoble Cedex 9, France penelope.lamarque@gmail.com - - 2014
Land use and climate change are primary causes of changes in the supply of ecosystem services (ESs). Although the consequences of climate change on ecosystem properties and associated services are well documented, the cascading impacts of climate change on ESs through changes in land use are largely overlooked. We present ...
Passey Chaitali C Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ; Presently at Bristol-Myers Squibb, Princeton, - - 2014
The objective was to develop a quantitative model of disease progression of knee osteoarthritis over 6 years using the total WOMAC score from patients enrolled into the Osteoarthritis Initiative (OAI) study. The analysis was performed using data from the Osteoarthritis Initiative database. The time course of the total WOMAC score ...
Hatswell Anthony J - - 2014
BackgroundHealth-related quality of life is often collected in clinical studies, and forms a cornerstone of economic evaluation. This study had two objectives, firstly to report and compare pre- and post-progression health state utilities in advanced melanoma when valued by different methods and secondly to explore the validity of progression-based health ...
Dicken Anthony A Imaging Science Group, Rosalind Franklin Building, Nottingham Trent University, Nottingham NG11 8NS, - - 2014
We present the results of a computer modelling package designed to simulate X-ray diffraction imaging employing focal construct geometry. The paths of coherently diffracted X-rays are modelled by ray-tracing. The results of the study show good agreement between simulated and measured data obtained in the laboratory. The validation of the ...
Bayrampour Hamideh H Department of Pediatrics, Faculty of Medicine - - 2014
Abstract The screening for anxiety in obstetric settings has been challenging due to time and knowledge constraints. Brief, valid, and reliable instruments can provide health care professionals with a quick and easy method to assess anxiety. Three six-item forms of the State Anxiety Inventory scale have been constructed. The purpose ...
Jefferson J Ashley JA Division of Nephrology, Department of Medicine, University of Washington, Seattle, WA. Electronic address: - - 2014
Focal segmental glomerulosclerosis (FSGS) is a histologic pattern of injury on kidney biopsy that can arise from a diverse range of causes and mechanisms. Although primary and secondary forms are described based on the underlying cause, there are many common factors that underlie the development of this segmental injury. In ...
McCandlish David M - - 2014
Many models of evolution calculate the rate of evolution by multiplying the rate at which new mutations originate within a population by a probability of fixation. Here we review the historical origins, contemporary applications, and evolutionary implications of these "origin-fixation" models, which are widely used in evolutionary genetics, molecular evolution, ...
Vlaanderen Willem W Gynaecologist retired, Malden, the - - 2014
Prof. Christiansen does not share my view that recurrent miscarriage (RM) is not a useful clinical concept (1). However, at one point we seem to agree: the absence of statistical reasons to assume that RM is not a chance event. He writes: "Due to all these uncertainties, these kinds of ...
Farzaneh S S Zaragoza University, Edificio Betacourt (Campus Río Ebro), C/ Maria de Luna s/n, 50018 , Saragossa, - - 2014
Slipped capital femoral epiphysis (SCFE) is one of the most common disorders of adolescent hips. A number of works have related the development of SCFE to mechanical factors. Due to the difficulty of diagnosing SCFE in its early stages, the disorder often progresses over time, resulting in serious side effects. ...
Van Eyndhoven G G iMinds-Vision Lab, University of Antwerp, Universiteitsplein 1, B-2610 Wilrijk, Belgium. Electronic address: - - 2014
Electron tomography is currently a versatile tool to investigate the connection between the structure and properties of nanomaterials. However, a quantitative interpretation of electron tomography results is still far from straightforward. Especially accurate quantification of pore-space is hampered by artifacts introduced in all steps of the processing chain, i.e., acquisition, ...
Schlebusch T T Chair for Medical Information Technology, Helmholtz Institute for Biomedical Engineering, RWTH Aachen University, Pauwelsstr. 20, 52074 Aachen, - - 2014
Non-invasive estimation of bladder volume is required to progress from scheduled voiding to a demand-driven emptying scheme for patients with impaired bladder volume sensation. Electrical impedance tomography (EIT) is a promising candidate for the non-invasive monitoring of bladder volume. This article focuses on four estimation algorithms used to map recorded ...
Marinus Johan J Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands. Electronic address: - - 2014
Disease progression in Parkinson's disease is often calculated in data from cross-sectional studies, where a severity score (e.g. UPDRS-motor score) is divided by disease duration. While this intuitively may seem a plausible approach, it is uncertain if these rates are similar to those calculated from longitudinal data. The aim of ...
Flanagan S S Cubist, San Diego, CA, USA - - 2014
Tedizolid phosphate is a novel antibacterial prodrug that is rapidly and extensively converted to its active moiety tedizolid. We developed a population pharmacokinetics (PK) model for tedizolid using pooled data from seven densely and sparsely sampled clinical trials evaluating oral and intravenous tedizolid. Model-derived exposure estimates were evaluated for relationships ...
Myerson Joel J Washington University. Electronic address: - - 2014
111 participants, recruited from Amazon's MTurk worker pool, completed Kirby's (2009) monetary choice questionnaire, which involves choosing between immediate, but smaller rewards and delayed, but larger rewards. Individual participants' responses were scored in three ways: first, by calculating the proportion of choices of the delayed rewards; second; using the scoring ...
Meckler A Nele AN Geological Institute, ETH Zurich, Sonneggstrasse, 5, 8092, Zürich, - - 2014
Carbonate clumped isotope thermometry is a powerful new technique increasingly used in many fields in earth science. Recently, it has been shown that clumped isotope measurements can be performed with a Kiel carbonate preparation device and micro-volume analyses, allowing measurements of small (1.5-2 mg) carbonate samples. However, common data correction ...
Fahey Michael T MT School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia; The Victorian Centre for Biostatistics (ViCBiostat), Melbourne, Victoria, - - 2014
An important goal of many epidemiological studies is to estimate the magnitude of association between an exposure and an outcome. Exposure measurement error causes bias in such estimates of association and can be substantial. In this article, we describe the problem of exposure measurement error and its effects. We show ...
Coates James J Department of Oncology, Medical Physics Unit, McGill University, Montreal, Quebec, - - 2014
Radiation-induced lung injury (RILI) is a prevalent side effect in patients who undergo thoracic irradiation as part of their cancer treatment. Preclinical studies play a major role in understanding disease onset under controlled experimental conditions. The aim of this work is to develop a single-chambered optimized, non-invasive, whole-body plethysmograph prototype ...
Hawi Nael N Trauma Department of the Hannover Medical School (MHH), Carl-Neuberg-Str. 1, 30625, Hannover, Germany, - - 2014
Conventional intraoperative determination of lower limb alignment is essential for orthopedic surgical treatment. Current methods include the cable, alignment rod, and axis board methods. Are there differences in accuracy and reliability? What are the individual differences in applicability and radiation exposure? Twenty legs from 12 fresh-frozen cadavers were randomly selected. ...
Kerns James R - - 2014
The multileaf collimator (MLC) is a critical component to accurate intensity-modulated radiotherapy (IMRT) delivery. This study examined MLC positional accuracy via MLC logs from Varian machines from six institutions and three delivery techniques to evaluate typical positional accuracy and treatment and mechanical parameters that affect accuracy. Typical accuracy achieved was ...
Pavošević Fabijan F Department of Chemistry, Virginia Tech, Blacksburg, Virginia 24061, - - 2014
We present a production implementation of reduced-scaling explicitly correlated (F12) coupled-cluster singles and doubles (CCSD) method based on pair-natural orbitals (PNOs). A key feature is the reformulation of the explicitly correlated terms using geminal-spanning orbitals that greatly reduce the truncation errors of the F12 contribution. For the standard S66 benchmark ...
Jeurissen Ben B iMinds - Vision Lab, Dept. of Physics, University of Antwerp, Belgium; The Florey Institute of Neuroscience and Mental Health, Melbourne, Australia. Electronic address: - - 2014
Constrained spherical deconvolution (CSD) has become one of the most widely used methods to extract white matter (WM) fibre orientation information from diffusion-weighted MRI (DW-MRI) data, overcoming the crossing fibre limitations inherent in the diffusion tensor model. It is routinely used to obtain high quality fibre orientation distribution function (fODF) ...
Ross David E DE Virginia Institute of Neuropsychiatry, Midlothian, VA; Virginia Commonwealth University, Richmond, VA. Electronic address: - - 2014
A recent meta-analysis by Hedman et al. allows for accurate estimation of brain volume changes throughout the life span. Additionally, Tate et al. showed that intracranial volume at a later point in life can be used to estimate reliably brain volume at an earlier point in life. These advancements were ...
Meija Juris - - 2014
Uncertainty of the result from the standard addition method is often underestimated due to neglect of the covariance between the intercept and the slope. In order to simplify the data analysis from standard addition experiments, we propose x-y coordinate swapping in conventional linear regression. Unlike the ratio of the intercept ...
Mansour Joseph M JM Department of Mechanical & Aerospace Engineering, Case Western Reserve University, 2123 Martin Luther King Jr. Drive, Glennan Building Room 616A, Cleveland, OH, 44106, USA, - - 2014
Our ultimate goal is to non-destructively evaluate mechanical properties of tissue-engineered (TE) cartilage using ultrasound (US). We used agarose gels as surrogates for TE cartilage. Previously, we showed that mechanical properties measured using conventional methods were related to those measured using US, which suggested a way to non-destructively predict mechanical ...
Seidi Foad F Department of Health and Sport Medicine, University of Tehran, Tehran, - - 2014
The amount of postural sway and sagittal deviation of lumbar lordosis angle in measurements of standing lumbar curvature obtained by flexible curve can be decreased when using a spine stabilizer instrument. However, this assumption has not been investigated so far. This study aims to determine the effect of using a ...
Aravkin Aleksandr Y - - 2014
Reconstruction of a function from noisy data is key in machine learning and is often formulated as a regularized optimization problem over an infinite-dimensional reproducing kernel Hilbert space (RKHS). The solution suitably balances adherence to the observed data and the corresponding RKHS norm. When the data fit is measured using ...
Qiu Yue Y 1] State Key Laboratory of Natural and Biomimetic Drugs (Peking University), Beijing 100191, China [2] Department of Pharmaceutics, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, - - 2014
Aim:Biomarkers and image markers of Alzheimer's disease (AD), such as cerebrospinal fluid Aβ42 and p-tau, are effective predictors of cognitive decline or dementia. The aim of this study was to integrate these markers with a disease progression model and to identify their abnormal ranges.Methods:The data of 395 participants, including 86 ...
Zhao Zhibiao Z Department of Statistics, Penn State University, University Park, PA - - 2014
We investigate asymptotic properties of least-absolute-deviation or median quantile estimates of the location and scale functions in nonparametric regression models with dependent data from multiple subjects. Under a general dependence structure that allows for longitudinal data and some spatially correlated data, we establish uniform Bahadur representations for the proposed median ...
Sokolova Alexandra B AB *Southern Urals Biophysics Institute (SUBI), Ozyorsk, Chelyabinsk Region, Russia; †Radiobiology Division, School of Medicine, University of Utah, Salt Lake City, - - 2014
Comparisons between results of in vivo counting measurements of americium burden and results from radiochemical analyses of organ samples taken at autopsy of 11 cases of former Mayak workers were made. The in vivo counting measurements were performed 3-8 y before death. The best agreement between in vivo counting measurements ...
Bian Wei - - 2014
In this brief, we show that minimizing nearest neighbor classification error (MNNE) is a favorable criterion for supervised linear dimension reduction (SLDR). We prove that MNNE is better than maximizing mutual information in the sense of being a proxy of the Bayes optimal criterion. Based on kernel density estimation, we ...
Bonett Douglas D University of - - 2014
Bonett and Wright (2011) proposed a simple and accurate sample size planning formula for estimating a squared multiple correlation with desired relative precision. Shieh (2013) incorrectly evaluated the accuracy of the Bonett-Wright formula. To address a criticism of Shieh that the Bonett-Wright formula was not examined under a wider range ...
Ballhausen Hendrik H Department of Radiotherapy and Radiation Oncology, University Hospital of the Ludwig-Maximilians-University, Marchioninistraße 15, 81377 Munich, - - 2014
To identify the relevant technical sources of error of a system based on three-dimensional ultrasound (3D US) for patient positioning in external beam radiotherapy. To quantify these sources of error in a controlled laboratory setting. To estimate the resulting end-to-end geometric precision of the intramodality protocol. Two identical free-hand 3D ...
Prathosh A P AP Department of Electrical Engineering, Indian Institute of Science, Bangalore 560012, India prathoshap@ee.iisc.ernet.in, - - 2014
This paper proposes an automatic acoustic-phonetic method for estimating voice-onset time of stops. This method requires neither transcription of the utterance nor training of a classifier. It makes use of the plosion index for the automatic detection of burst onsets of stops. Having detected the burst onset, the onset of ...
Tang Yi - - 2014
A novel framework of learning-based super-resolution is proposed by employing the process of learning from the estimation errors. The estimation errors generated by different learning-based super-resolution algorithms are statistically shown to be sparse and uncertain. The sparsity of the estimation errors means most of estimation errors are small enough. The ...
Martinez Edson Z EZ Department of Social Medicine, University of São Paulo (USP), Ribeirão Preto School of Medicine, Brazil. Electronic address: - - 2014
The cure fraction models have been widely used to analyze survival data in which a proportion of the individuals is not susceptible to the event of interest. In this article, we introduce a bivariate model for survival data with a cure fraction based on the three-parameter generalized Lindley distribution. The ...
Kuyoc-Carrillo Vicente F VF Centro de Investigación Farmacológica y Biotecnológica, Médica Sur, Mexico City, 14050, - - 2014
Preclinical Research The increasing awareness that drugs may have the clinical effect through the interaction with multiple targets is encouraging the screening of investigational compounds across multiple biological endpoints. As the number and complexity of chemogenomics data sets increase, more computational approaches are being developed for the efficient analysis of ...
Kotłowska Alicja A Department of Food Sciences, Faculty of Pharmacy, Medical University of Gdańsk, Gdańsk, 80-416, - - 2014
Preclinical Research Metabolomics deals with the global assessment of the metabolites present in a biological system to evaluate the progress of the disease, select potential biomarkers, and provide insights into the underlying pathophysiology. As metabolomic analysis generates large quantities of data, multivariate data analysis techniques and chemometrics are often used ...
Acuna Daniel E DE Rehabilitation Institute of Chicago - - 2014
Sequence production tasks are a standard tool to analyze motor learning, consolidation, and habituation. As sequences are learned, movements are typically grouped into subsets or chunks. For example, most Americans memorize telephone numbers in two chunks of 3 digits, and one chunk of 4. Studies generally use response times or ...
Ilahi Omer A OA Texas Arthroscopy & Sports Medicine Institute, Houston, Texas, U.S.A.. Electronic address: - - 2014
To assess interobserver and intraobserver agreement of estimating anterior cruciate ligament (ACL) femoral tunnel positioning arthroscopically using circular and linear (noncircular) estimation methods and to determine whether overlay template visual aids improve agreement. Standardized intraoperative pictures of femoral tunnel pilot holes (taken with a 30° arthroscope through an anterolateral portal ...
Marasco Daniel Eric - - 2014
Quantifying green roof evapotranspiration (ET) in urban climates is important for assessing environmental benefits, including stormwater runoff attenuation and urban heat island mitigation. In this study, a dynamic chamber method was developed to quantify ET on two extensive green roofs located in New York City, NY. Hourly chamber measurements taken ...
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