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Culley Kirsty L KL Tissue Engineering Regeneration and Repair Program, Research Division, The Hospital for Special Surgery, Caspary Research Building, 5th Floor, 535 East 70th Street, New York, NY, 10021, USA, - - 2015
The surgical model of destabilization of the medial meniscus (DMM) has become a gold standard for studying the onset and progression of posttraumatic osteoarthritis (OA). The DMM model mimics clinical meniscal injury, a known predisposing factor for the development of human OA, and permits the study of structural and biological ...
Shahlaei Mohsen M Novel Drug Delivery Research Center, School of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, - - 2014
Taking into account the uncertainties involved in 3D model of biomolecule developed by homology modeling (HM), it is important to opportunely validate the initial structure before employing for different purposes such as drug design. Extended simulation times and the necessity of correct representation of interactions within the protein and the ...
Guimaraes Rodrigo Soares RS Department of Cell Biology, Center for Molecular Medicine, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands; Department of Cell Biology, Center for Molecular Medicine, University Medical Center Groningen, A. Deusinglaan 1, 9713 AV Groningen, The - - 2014
Autophagy is a conserved intracellular catabolic pathway that degrades unnecessary or dysfunctional cellular components. Components destined for degradation are sequestered into double-membrane vesicles called autophagosomes, which subsequently fuse with the vacuole/lysosome delivering their cargo into the interior of this organelle for turnover. Autophagosomes are generated through the concerted action of ...
Tang Kewei - - 2014
Benefiting from its effectiveness in subspace segmentation, low-rank representation (LRR) and its variations have many applications in computer vision and pattern recognition, such as motion segmentation, image segmentation, saliency detection, and semisupervised learning. It is known that the standard LRR can only work well under the assumption that all the ...
Coleman Roger R RR Director of Research, Gonstead Clinical Studies Society, Othello, - - 2014
The purpose of this exploratory study was to evaluate the amount of error in retrolisthesis measurement due to measurement methods or projection factors inherent in spinal radiography. In addition, this study compared how accurately these methods determine positions of the lumbar vertebrae being studied and the expected projected size of ...
Nater Alexander A Anthropological Institute & Museum, University of Zurich, Zurich, - - 2014
Investigating how different evolutionary forces have shaped patterns of DNA variation within and among species requires detailed knowledge of their demographic history. Orang-utans, whose distribution is currently restricted to the Southeast Asian islands of Borneo (Pongo pygmaeus) and Sumatra (Pongo abelii), have likely experienced a complex demographic history, influenced by ...
Gomez-Cabrero David - - 2014
Chronic Obstructive Pulmonary Disease (COPD) patients are characterized by heterogeneous clinical manifestations and patterns of disease progression. Two major factors that can be used to identify COPD subtypes are muscle dysfunction/wasting and co-morbidity patterns. We hypothesized that COPD heterogeneity is in part the result of complex interactions between several genes ...
Dent Jennifer E JE Group of Clinical Genomic Networks, Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Shanghai, PR China. Quintiles, Global Biostatistics, Reading, Berkshire, - - 2014
Mechanotransduction -the ability to output a biochemical signal from a mechanical input- is related to the initiation and progression of a broad spectrum of molecular events. Yet, the characterization of mechanotransduction lacks some of the most basic tools as, for instance, it can hardly be recognized by enrichment analysis tools, ...
Klein Sabine S Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine Hannover, Germany; Center for Systems Neuroscience, Hannover, - - 2014
Despite more than 20 clinically approved antiepileptic drugs (AEDs), there remains a substantial unmet clinical need for patients with refractory (AED-resistant) epilepsy. Animal models of refractory epilepsy are needed for at least two goals; (1) better understanding of the mechanisms underlying resistance to AEDs, and (2) development of more efficacious ...
Chawade Aakash - - 2014
High-throughput multiplexed protein quantification using mass spectrometry is steadily increasing in popularity, with the two major techniques being data-dependent acquisition (DDA) and targeted acquisition using selected reaction monitoring (SRM). However, both techniques involve extensive data processing, which can be performed by a multitude of different software solutions. Analysis of quantitative ...
Cueno Marni E ME Department of Microbiology, Nihon University, School of Dentistry, Tokyo 101-8310, Japan. Electronic address: - - 2014
Porphyromonas gingivalis FimA is a major aetiological agent in periodontal disease development, however, its structure has never been determined. Here, we established the mature P. gingivalis FimA ab initio model of all six FimA variants. We determined the conserved amino acid sequences of each FimA variant and generated mature FimA ...
Ruiz Luz M LM a Technologies for Water Management and Treatment Research Group , University of Granada , Granada , - - 2014
Five different wastewater COD fractionation methods were employed for simulating an experimental MBR wastewater treatment plant using WEST. The predictions of dynamic simulations using as input the data obtained according to each influent characterization methodology were compared with the results of the experimental system and differences between experimental and predicted ...
Krzak Joseph J JJ Midwestern University, Physical Therapy Program, College of Health Sciences, 555 31st Street, Downers Grove, IL, United States; Shriners Hospitals for Children®-Chicago, 2211 North Oak Park Avenue, Chicago, IL, United States. Electronic address: - - 2014
Elevated kinematic variability of the foot and ankle segments exists during gait among individuals with equinovarus secondary to hemiplegic cerebral palsy (CP). Clinicians have previously addressed such variability by developing classification schemes to identify subgroups of individuals based on their kinematics. To identify kinematic subgroups among youth with equinovarus secondary ...
Grienke Ulrike U Institute of Pharmacy/Pharmacognosy and Center for Molecular Biosciences Innsbruck, University of Innsbruck, Innrain 80-82, 6020 Innsbruck, Austria. Electronic address: - - 2014
The species complex around the medicinal fungus Ganoderma lucidum Karst. (Ganodermataceae) is widely known in traditional medicines, as well as in modern applications such as functional food or nutraceuticals. A considerable number of publications reflects its abundance and variety in biological actions either provoked by primary metabolites, such as polysaccharides, ...
Chu Chengwen C Institute for Surgical Technology and Biomechanics, University of Bern, Stauffacherstr. 78, 3014, Bern, - - 2014
Extraction of surface models of a hip joint from CT data is a pre-requisite step for computer assisted diagnosis and planning (CADP) of periacetabular osteotomy (PAO). Most of existing CADP systems are based on manual segmentation, which is time-consuming and hard to achieve reproducible results. In this paper, we present ...
Zheng Xin X Department of Spine Surgery, the Affiliated Drum Tower Hospital of Nanjing University Medical - - 2014
An animal study. To create a reliable porcine scoliosis model representative of early onset scoliosis (EOS) without violation of the vertebral elements along the curve. To develop new nonfusion techniques for the treatment of early onset scoliosis, a reliable large animal model with remarkable growth potential is required. However, a ...
Leoutsakos Jeannie-Marie S JM Department of Psychiatry, Division of Geriatric Psychiatry and Neuropsychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, - - 2014
Several longitudinal studies of Alzheimer's disease (AD) report heterogeneity in progression. We sought to identify groups (classes) of progression trajectories in the population-based Cache County Dementia Progression Study (N = 328) and to identify baseline predictors of membership for each group. We used parallel-process growth mixture models to identify latent classes of ...
Park Sang Hyun SH Department of Radiology and BRIC, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina - - 2014
Accurate prostate segmentation is necessary for maximizing the effectiveness of radiation therapy of prostate cancer. However, manual segmentation from 3D CT images is very time-consuming and often causes large intra- and interobserver variations across clinicians. Many segmentation methods have been proposed to automate this labor-intensive process, but tedious manual editing ...
Clogenson Marine M École Polytechnique Fédérale de Lausanne, Instant-Lab, Rue de la Maladière 71b, 2000, Neuchâtel, Switzerland, - - 2014
Statistical shape and appearance models play an important role in reducing the segmentation processing time of a vertebra and in improving results for 3D model development. Here, we describe the different steps in generating a statistical shape model (SSM) of the second cervical vertebra (C2) and provide the shape model ...
Huang Shih-Hsuan SH Department of Transportation and Logistics Management, National Chiao-Tung University, 4F, 118, Section 1, Chung Hsiao W. Road, Taipei 10044, Taiwan, ROC. Electronic address: - - 2014
Exploring the continual process of drivers allocating their attention under varying conditions could be vital for preventing motor vehicle crashes. This study aims to model visual behaviors and to estimate the effects of various contributing factors on driver's vision transitions. A visual attention allocation framework, based on certain contributing attributes ...
Wood A J AJ Australian Regenerative Medicine Institute, Building 75, Level 1, Clayton Campus, Wellington Road, Melbourne, Victoroia 3181, - - 2014
The congenital muscular dystrophies (CMDs) are a clinically and genetically heterogeneous group of muscle disorders. Clinically hypotonia is present from birth, with progressive muscle weakness and wasting through development. For the most part, CMDs can mechanistically be attributed to failure of basement membrane protein laminin-α2 sufficiently binding with correctly glycosylated ...
Hirasawa Kazunori K Orthoptics and Visual Science, School of Allied Health Sciences, Kitasato University, 1-15-1 Kitasato, MInami-ku, Sagamihara, Kanagawa, 252-0373, - - 2014
Purpose: To develop new visual field (VF) sectors based on point-wise rates of glaucomatous VF progression ('Progression Sectors') and to evaluate their usefulness for predicting future progression. Methods: A training dataset consisting of 10 VFs from each of 412 eyes in 412 open angle glaucoma patients and a validation dataset ...
Iester Michele M MM Department of Ophthalmology, UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA Eye Clinic, DiNOGMI, University of Genoa, Genoa, - - 2014
To evaluate agreement among experts of Heidelberg retina tomography's (HRT) topographic change analysis (TCA) printout interpretations of glaucoma progression and explore methods for improving agreement. 109 eyes of glaucoma, glaucoma suspect and healthy subjects with ≥5 visits and 2 good quality HRT scans acquired at each visit were enrolled. TCA ...
Figueiredo Danieli Forgiarini DF NBLI - Núcleo de Bioinformática do Laboratório de Imunogenética, Departamento de Genética, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil; Programa de Pós-Graduação em Genética e Biologia Molecular (PPGBM), Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Rio Grande do Sul, - - 2014
Human α-l-iduronidase (IDUA) is a member of glycoside hydrolase family and is involved in the catabolism of glycosaminoglycans (GAGs), heparan sulfate (HS) and dermatan sulfate (DS). Mutations in this enzyme are responsible for mucopolysaccharidosis I (MPS I), an inherited lysosomal storage disorder. Despite great interest in determining and studying this ...
Smith Darci R DR Southern Research Institute, Frederick, MD 21701, United States. Electronic address: - - 2014
The term "viral hemorrhagic fever" (VHF) designates a syndrome of acute febrile illness, increased vascular permeability and coagulation defects which often progresses to bleeding and shock and may be fatal in a significant percentage of cases. The causative agents are some 20 different RNA viruses in the families Arenaviridae, Bunyaviridae, ...
Nath Abhigyan A Bioinformatics Section, Mahila Mahavidyalaya, Banaras Hindu University, Varanasi 221005, India. Electronic address: - - 2014
Organisms thriving at extreme cold surroundings are called as psychrophiles and they present a wealth of knowledge about sequence adjustments in proteins that had occurred during the adaptation to low temperatures. In this paper, we propose a new cascading model to investigate the basis for psychrophilicity. In this model, a ...
Jedynak Bruno M BM Department of Applied Mathematics and Statistics, Johns Hopkins University, Baltimore, MD, USA; Center for Imaging Science, Johns Hopkins University, Baltimore, MD, USA; Laboratoire de Mathématiques Paul Painlevé, Université des Sciences et Technologies de Lille, Villeneuve d'Ascq, France. Electronic address: - - 2014
Understanding the time-dependent changes of biomarkers related to Alzheimer's disease (AD) is a key to assessing disease progression and measuring the outcomes of disease-modifying therapies. In this article, we validate an AD progression score model which uses multiple biomarkers to quantify the AD progression of subjects following 3 assumptions: (1) ...
Immonen Taina T - - 2014
BackgroundHIV-1 can persist for the duration of a patient¿s life due in part to its ability to hide from the immune system, and from antiretroviral drugs, in long-lived latent reservoirs. Latent forms of HIV-1 may also be disproportionally involved in transmission. Thus, it is important to detect and quantify latency ...
Nociarová Dominika D Unitat d'Antropologia Biològica, Departament de Biologia Animal, Biologia Vegetal i Ecologia, Universitat Autònoma de Barcelona, 08193 Bellaterra, Barcelona, Catalonia, Spain; Visualforensic, Parc Audiovisual de Catalunya, Ctra. BV-1274, km 1, Edificio A, 1ª planta, 08225 Terrassa, Barcelona, - - 2014
Part of the study of skeletal remains or corpses in advance decay located in the field involves determining their origin. They may be the result of criminal activity, accident, unearthed because of erosion, or they may also have originated from a cemetery. The discovery site, condition of the remains, and ...
Nikolaev Pavel - - 2014
Applications of carbon nanotubes continue to advance, with substantial progress in nanotube electronics, conductive wires, and transparent conductors to name a few. However, wider application remains impeded by a lack of control over production of nanotubes with the desired purity, perfection, chirality and number of walls. This is partly due ...
Yousefi Siavash S Department of Bioengineering, University of Washington, Seattle, WA 98195, - - 2014
Optical coherence tomography (OCT) based microangiography is capable of visualizing 3D functional blood vessel networks within microcirculatory tissue beds in vivo. To provide the quantitative information of vasculature from the microangiograms such as vessel diameter and morphology, it is necessary to develop efficient vessel segmentation algorithms. In this paper, we ...
Devillers J J a CTIS , Rillieux La Pape , - - 2014
Human arboviral diseases have emerged or re-emerged in numerous countries worldwide due to a number of factors including the lack of progress in vaccine development, lack of drugs, insecticide resistance in mosquitoes, climate changes, societal behaviours, and economical constraints. Thus, Aedes aegypti is the main vector of the yellow fever ...
Lindner Benjamin B UT/ORNL Center for Molecular Biophysics, Oak Ridge National Laboratory, 1 Bethel Valley Road, Bldg. 6011, Oak Ridge, TN, 37830-6309, - - 2014
One-dimensional (spherically averaged) powder diffraction diagrams are commonly used to determine the degree of cellulose crystallinity in biomass samples. Here, it is shown using molecular modeling how disorder in cellulose fibrils can lead to considerable uncertainty in conclusions drawn concerning crystallinity based on 1-D powder diffraction data alone. For example, ...
Rodriguez Jesse M JM Stanford - - 2014
Identity-by-descent (IBD) inference is the problem of establishing a genetic connection between two individuals through a genomic segment that is inherited by both individuals from a recent common ancestor. IBD inference is an important preceding step in a variety of population genomic studies, ranging from demographic studies to linking genomic ...
Liu Jingfa J Jiangsu Engineering Center of Network Monitoring, Nanjing University of Information Science & Technology, Nanjing, 210044, China and School of Computer & Software, Nanjing University of Information Science & Technology, Nanjing, 210044, China and Network Information Center, Nanjing University of Information Science & Technology, Nanjing 210044, - - 2014
Finding the global minimum-energy structure is one of the main problems of protein structure prediction. The face-centered-cubic (fcc) hydrophobic-hydrophilic (HP) lattice model can reach high approximation ratios of real protein structures, so the fcc lattice model is a good choice to predict the protein structures. The lacking of an effective ...
Eroglu Deniz D Potsdam Institute for Climate Impact Research, 14473 Potsdam, Germany and Department of Physics, Humboldt University, 12489 Berlin, - - 2014
The Shannon entropy of a time series is a standard measure to assess the complexity of a dynamical process and can be used to quantify transitions between different dynamical regimes. An alternative way of quantifying complexity is based on state recurrences, such as those available in recurrence quantification analysis. Although ...
Gonçalves Rita de Cassia Braga Rde - - 2014
This study aimed to evaluate the use of hidden Markov models (HMM) for the segmentation of person names and its influence on record linkage. A HMM was applied to the segmentation of patient's and mother's names in the databases of the Mortality Information System (SIM), Information Subsystem for High Complexity ...
Lee Hansang H Department of Electrical Engineering, Korea Advanced Institute of Science and Technology, Daejeon, South - - 2014
We propose a graph-cut-based segmentation method for the anterior cruciate ligament (ACL) in knee MRI with a novel shape prior and label refinement. As the initial seeds for graph cuts, candidates for the ACL and the background are extracted from knee MRI roughly by means of adaptive thresholding with Gaussian ...
Henson Stephanie A SA National Oceanography Centre, European Way, Southampton SO14 3ZH, UK - - 2014
Sustained observations (SOs) have provided invaluable information on the ocean's biology and biogeochemistry for over 50 years. They continue to play a vital role in elucidating the functioning of the marine ecosystem, particularly in the light of ongoing climate change. Repeated, consistent observations have provided the opportunity to resolve temporal ...
Koerber Susanne S Freiburg University of - - 2014
The development of scientific thinking was assessed in 1,581 second, third, and fourth graders (8-, 9-, 10-year-olds) based on a conceptual model that posits developmental progression from naïve to more advanced conceptions. Using a 66-item scale, five components of scientific thinking were addressed, including experimental design, data interpretation, and understanding ...
Nguyen Hai H Department of Chemistry, ‡Laufer Center for Physical and Quantitative Biology and §Graduate Program in Biochemistry and Structural Biology, Stony Brook University , Stony Brook, New York 11794-5252, United - - 2014
The millisecond time scale needed for molecular dynamics simulations to approach the quantitative study of protein folding is not yet routine. One approach to extend the simulation time scale is to perform long simulations on specialized and expensive supercomputers such as Anton. Ideally, however, folding simulations would be more economical ...
Dankulchai Pittaya P Mount Vernon Cancer Centre, Northwood, United Kingdom; Division of Radiation Oncology, Department of Radiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand. Electronic address: - - 2014
To investigate the optimal distribution of sources using high dose rate brachytherapy to deliver a focal boost to a dominant lesion within the whole prostate gland based on multi-parametric magnetic resonance imaging (mpMRI). Sixteen patients with prostate cancer underwent mpMRI each of which demonstrated a dominant lesion. There were single ...
Zhang Ning N Department of Biomedical Engineering, Tianjin Key Lab of BME Measurement, Tianjin University, Tianjin, 300072, People's Republic of - - 2014
More than ten thousand coding variants are contained in each human genome; however, our knowledge of the way genetic variants underlie phenotypic differences is far from complete. Small insertions and deletions (indels) are one of the most common types of human genetic variants, and indels play a significant role in ...
Boroujerdian Amin Mirza AM Faculty of Civil & Environmental Engineering, Tarbiat Modares University, Tehran, Iran. Electronic address: - - 2014
Currently, high social and economic costs in addition to physical and mental consequences put road safety among most important issues. This paper aims at presenting a novel approach, capable of identifying the location as well as the length of high crash road segments. It focuses on the location of accidents ...
Chandra Siddharth - - 2014
The 1918-19 'Spanish' Influenza was the most devastating pandemic in recent history, with estimates of global mortality ranging from 20 to 50 million. The focal point of the pandemic was India, with an estimated death toll of between 10 and 20 million. We will characterize the pattern of spread, mortality, ...
Park Jungkap - - 2014
Multibody potentials accounting for cooperative effects of molecular interactions have shown better accuracy than typical pairwise potentials. The main challenge in the development of such potentials is to find relevant structural features that characterize the tightly folded proteins. Also, the side-chains of residues adopt several specific, staggered conformations, known as ...
Maidment Susannah C R SC Department of Earth Sciences, The Natural History Museum, Cromwell Road, London, SW7 5BD, UK, - - 2014
The exceptionally rare transition to quadrupedalism from bipedal ancestors occurred on three independent occasions in ornithischian dinosaurs. The possible driving forces behind these transitions remain elusive, but several hypotheses-including the development of dermal armour and the expansion of head size and cranial ornamentation-have been proposed to account for this major ...
Lamarque Pénélope P Laboratoire d'Ecologie Alpine, Unité Mixte de Recherche 5553, Centre National de la Recherche Scientifique, Université Joseph Fourier, BP 53, 38041 Grenoble Cedex 9, France penelope.lamarque@gmail.com - - 2014
Land use and climate change are primary causes of changes in the supply of ecosystem services (ESs). Although the consequences of climate change on ecosystem properties and associated services are well documented, the cascading impacts of climate change on ESs through changes in land use are largely overlooked. We present ...
Passey Chaitali C Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ; Presently at Bristol-Myers Squibb, Princeton, - - 2014
The objective was to develop a quantitative model of disease progression of knee osteoarthritis over 6 years using the total WOMAC score from patients enrolled into the Osteoarthritis Initiative (OAI) study. The analysis was performed using data from the Osteoarthritis Initiative database. The time course of the total WOMAC score ...
Hatswell Anthony J - - 2014
BackgroundHealth-related quality of life is often collected in clinical studies, and forms a cornerstone of economic evaluation. This study had two objectives, firstly to report and compare pre- and post-progression health state utilities in advanced melanoma when valued by different methods and secondly to explore the validity of progression-based health ...
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