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Johansson Asa M AM Pharmacometrics Research Group, Department of Pharmaceutical Biosciences, Uppsala University, P.O. Box 591, 751 24 , Uppsala, - - 2014
NONMEM is the most widely used software for population pharmacokinetic (PK)-pharmacodynamic (PD) analyses. The latest version, NONMEM 7 (NM7), includes several sampling-based estimation methods in addition to the classical methods. In this study, performance of the estimation methods available in NM7 was investigated with respect to bias, precision, robustness and ...
Takezawa Kentaro K 1Osaka University Graduate School of - - 2014
Various animal models have been used in research into bladder dysfunction, and in vivo cystometry is a common method to analyze bladder function in animals. However, it is rather difficult to perform reliably in small animals. Transabdominal bladder ultrasonography combined with cystometry in urethane-anesthetized mice have revealed physical inhibition of ...
Girard Gabriel G Sherbrooke Connectivity Imaging Lab (SCIL), Computer Science Department, Faculty of Science, Université de Sherbrooke, 2500 Boulevard Université, Sherbrooke, QC, Canada J1K 2R1; Project Team Athena, INRIA Sophia Antipolis Méditerranée, 2004 Route des Lucioles BP 93, 06902 Sophia Antipolis Cedex, France. Electronic address: - - 2014
Diffusion MRI tractography is often used to estimate structural connections between brain areas and there is a fast-growing interest in quantifying these connections based on their position, shape, size and length. However, a portion of the connections reconstructed with tractography is biased by their position, shape, size and length. Thus, ...
Wu Tim T Auckland Bioengineering Institute, The University of Auckland, Auckland, New - - 2014
A detailed biomechanical model of the human face driven by a network of muscles is a useful tool in relating the muscle activities to facial deformations. However, lengthy computational times often hinder its applications in practical settings. The objective of this study is to replace precise but computationally demanding biomechanical ...
Kounina Anna A Ecole Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland; Quantis, Parc scientifique EPFL, Bâtiment D, 1015 Lausanne, Switzerland. Electronic address: - - 2014
This paper develops continent-specific factors for the USEtox model and analyses the accuracy of different model architectures, spatial scales and archetypes in evaluating toxic impacts, with a focus on freshwater pathways. Inter-continental variation is analysed by comparing chemical fate and intake fractions between sub-continental zones of two life cycle impact ...
Parker Andrew S AS Department of Orthopedic Surgery, Baylor College of Medicine, Ben Taub General Hospital, Houston, TX; Dan L. Duncan Institute for Clinical and Translational Research, Baylor College of Medicine, Houston, TX; Department of Radiology, Baylor College of Medicine, Houston, - - 2014
To determine the reliability of measuring ulnar variance on lateral wrist radiographs and to compare this technique with previously described methods. Ulnar variance was measured in 100 normal wrist radiographs using the methods of perpendiculars, central reference point, and the lateral radiograph by 3 surgeons on 2 occasions. Intraobserver repeatability ...
Paul Sudhir S Department of Mathematics and Statistics, Trent University, Peterborough, Ontario, K9J7B8, - - 2014
Longitudinal (clustered) response data arise in many bio-statistical applications which, in general, cannot be assumed to be independent. Generalized estimating equation (GEE) is a widely used method to estimate marginal regression parameters for correlated responses. The advantage of the GEE is that the estimates of the regression parameters are asymptotically ...
Frątczak Katarzyna K Laboratory of Criminalistics, Adam Mickiewicz University, Św. Marcin 90, 61-809 Poznań, Poland; Department of Animal Taxonomy and Ecology, Adam Mickiewicz University, Umultowska 89, 61-614 Poznań, - - 2014
In order to estimate postmortem interval from immature insects, it is necessary to accurately determine which instars are present in a corpse sample. Unfortunately, most forensically useful beetles lack morphological features specific for particular instars, and the only way to distinguish larval instars of particular species is to measure their ...
Day Lukejohn W LW Division of Gastroenterology, San Francisco General Hospital and Trauma Center, San Francisco, California, USA; GI Health Outcomes, Policy and Economics (HOPE) Research Program and Center for Innovation in Access and Quality (CIAQ), Department of Medicine, University of California, San Francisco, California, - - 2014
Improvements in endoscopy center efficiency are needed, but scant data are available. To identify opportunities to improve patient throughput while balancing resource use and patient wait times in a safety-net endoscopy center. Safety-net endoscopy center. Outpatients undergoing endoscopy. A time and motion study was performed and a discrete event simulation ...
Kaduk Mateusz M Biosystems Data Analysis, Swammerdam Institute for Life Sciences, University of Amsterdam, Science Park 904, 1098 XH Amsterdam, The Netherlands; Netherlands Metabolomics Centre, Leiden, The - - 2014
Modern chromatography-based metabolomics measurements generate large amounts of data in the form of abundances of metabolites. An increasingly popular way of representing and analyzing such data is by means of association networks. Ideally, such a network can be interpreted in terms of the underlying biology. A property of chromatography-based metabolomics ...
Rose Matthias M Department of Quantitative Health Sciences, University of Massachusetts Medical School, Worcester, MA, USA; Department of Psychosomatic Medicine, Medical School, Charité Universitätsmedizin Berlin, Berlin, Germany. Electronic address: - - 2014
To document the development and psychometric evaluation of the Patient-Reported Outcomes Measurement Information System (PROMIS) Physical Function (PF) item bank and static instruments. The items were evaluated using qualitative and quantitative methods. A total of 16,065 adults answered item subsets (n>2,200/item) on the Internet, with oversampling of the chronically ill. ...
Ma Lijun L Department of Radiation Oncology, University of California, San Francisco, California. Electronic address: - - 2014
To investigate how millimeter-level margins beyond the gross tumor volume (GTV) impact peripheral normal brain tissue sparing for Gamma Knife radiosurgery. A mathematical formula was derived to predict the peripheral isodose volume, such as the 12-Gy isodose volume, with increasing margins by millimeters. The empirical parameters of the formula were ...
Sofka Michal - - 2014
Routine ultrasound exam in the second and third trimesters of pregnancy involves manually measuring fetal head and brain structures in 2-D scans. The procedure requires a sonographer to find the standardized visualization planes with a probe and manually place measurement calipers on the structures of interest. The process is tedious, ...
Tang Robert Y RY Biomolecular Sciences Program, Laurentian University, 935 Ramsey Lake Road, Sudbury, Ontario P3E 2C6, - - 2014
Develop a method to subtract fat tissue contributions to wide-angle x-ray scatter (WAXS) signals of breast biopsies in order to estimate the differential linear scattering coefficients μs of fatless tissue. Cancerous and fibroglandular tissue can then be compared independent of fat content. In this work phantom materials with known compositions ...
Yock Adam D AD Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030 and The Graduate School of Biomedical Sciences, The University of Texas Health Science Center at Houston, Houston, Texas - - 2014
The purpose of this work was to develop and evaluate the accuracy of several predictive models of variation in tumor volume throughout the course of radiation therapy. Nineteen patients with oropharyngeal cancers were imaged daily with CT-on-rails for image-guided alignment per an institutional protocol. The daily volumes of 35 tumors ...
Krawczky Bruna B Augusto Motta University Center (UNISUAM), Rio de Janeiro, - - 2014
Reference values for postural alignment in the coronal plane, as measured by computerized photogrammetry, have been established but not for the sagittal plane. The objective of this study is to propose reference values for angular measurements used for postural analysis in the sagittal plane for healthy adults. Electronic databases (PubMed, ...
Morente-Sánchez Jaime J Faculty of Sport Sciences, University of Granada , - - 2014
The aim of the present study was to cross-culturally adapt and validate the Spanish version of the Performance Enhancement Attitude Scale (PEAS). A cross-sectional multi-sample survey with 17 independent datasets was carried out. Cross-cultural adaptation of the PEAS into Spanish was conducted through forward/backward translations, consensus panels and comparative analyses ...
Tsanas Athanasios A Institute of Biomedical Engineering, Department of Engineering Science, Old Road Campus Research Building, University of Oxford, Headington, Oxford OX3 7DQ, United - - 2014
There has been consistent interest among speech signal processing researchers in the accurate estimation of the fundamental frequency ([Formula: see text]) of speech signals. This study examines ten [Formula: see text] estimation algorithms (some well-established and some proposed more recently) to determine which of these algorithms is, on average, better ...
Nakazawa Hisato H Department of Radiological Sciences, Nagoya University Graduate School of - - 2014
The brand-new version of gamma knife, Perfexion, is equipped with an automatic collimator arrangement system that does not require manual collimator exchange and a couch-traveling system that is approximately ten times faster than Model C, so treatment time with multiple shots is assumed to remain within a clinically acceptable range. ...
Chrószcz A A Division of Animal Anatomy, Department of Biostructure and Animal Physiology, Faculty of Veterinary Medicine, Wroclaw University of Environmental and Life Sciences, Wroclaw, Poland. - - 2014
The investigations were carried out on 17 modern half-breed horse skulls and their metacarpal and metatarsal bones. The basal length (BL), total length (TL), internal cranial cavity dimension and maximal length of metacarpus and metatarsus and maximal lateral length of metacarpus and metatarsus were measured according to Kiesewalter and von ...
Skomra Andrzej A Specialistic Neurological Consulting Room, Żary, - - 2014
Available literature analysis demonstrated smallness of studies of cranial base. The goal of the study was to analyse the medial fossa of the human cranium in the foetal period against other fossae. Survey material consisted of 110 human foetuses at a morphological age of 16-28 weeks of foetal life, CRL 98-220 mm. Anthropological, ...
Valsalan Jamuna J Dairy Cattle Breeding Division, National Dairy Research Institute, Karnal, 132001, Haryana, India, - - 2014
Selection for genetically superior Murrah buffaloes under Network Project on Buffalo Improvement, India, is presently based on milk yield, and it was observed that even in the absence of any direct selection pressure applied on fertility, there has been a downward trend in fertility associated with the selection for milk ...
Caune V V Université de Lorraine, CRAN, UMR 7039, 54500 Vandoeuvre-lès-Nancy, France; CNRS, CRAN, UMR 7039, - - 2014
Stereo-electroencephalography (SEEG) is considered as the golden standard for exploring targeted structures during pre-surgical evaluation in drug-resistant partial epilepsy. The depth electrodes, inserted in the brain, consist of several collinear measuring contacts (sensors). Clinical routine analysis of SEEG signals is performed on bipolar montage, providing a focal view of the ...
Zhao Song-Chuan SC Max Planck Institute for Dynamics and Self-Organization (MPIDS), 37077 Goettingen, Germany. - - 2014
Jammed packings of granular materials differ from systems normally described by statistical mechanics in that they are athermal. In recent years a statistical mechanics of static granular media has emerged where the thermodynamic temperature is replaced by a configurational temperature X which describes how the number of mechanically stable configurations ...
Nakao Megumi - - 2014
In preoperative planning for mandibular reconstructive surgery, it is necessary to determine the osteotomy lines for fibular shaping and the proper placement of fibular segments in the mandible. Although virtual surgical planning has been utilized in preoperative decision-making, current software designs require manual operation and a trial-and-error process to refine ...
Ledberg Anders - - 2014
Prevalence estimates of drug use, or of its consequences, are considered important in many contextsand may have substantial influence over public policy. However, it is rarely possible to simply countthe relevant individuals, in particular when the defining characteristics might be illegal, as in the druguse case. Consequently methods are needed ...
Kamarei Fahimeh F Department of Chemistry, University of Tennessee, Knoxville, TN 37996-1600, United - - 2014
The adsorption isotherms of the Naproxen enantiomers eluted with a mixture of carbon dioxide and methanol on a (R,R)-Whelk-O1 column were measured using frontal analysis and the inverse method. Sharp breakthrough fronts provided using a modified design of the instrument allowed an accurate determination of these isotherms. The adsorption model ...
Lee Joonsang J Department of Bioinformatics and Computational Biology, The University of Texas M.D. Anderson Cancer Center, Houston, TX, - - 2014
This study compared three methods for analyzing DCE-MRI data with a reference region (RR) model: a linear least-square fitting with numerical analysis (LLSQ-N), a nonlinear least-square fitting with numerical analysis (NLSQ-N), and an analytical analysis (NLSQ-A). The accuracy and precision of estimating the pharmacokinetic parameter ratios KR and VR, where ...
Jung Kee Wook KW Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, - - 2014
Anorectal manometry with simulated evacuation (SE) has limited applicability in predicting balloon expulsion (BE) test results. The newly developed high-resolution anorectal manometry (HRAM) technique can yield spatiotemporal plots with three-dimensional pressurization. We aimed to define new parameters based on three-dimensional integrated pressurized volume (IPV) for predicting the BE test results ...
Klein Christian - - 2014
Currently, the metatarsophalangeal angle (hallux valgus angle) is measured based on radiographic images. However, using X-ray examinations for epidemiological or screening purposes would be unethical, especially in children. For this reason it is discussed to measure the hallux valgus angle of the margo medialis pedis (medial border of the foot) ...
Pan Jianxin J School of Mathematics, The University of Manchester, Oxford Road, Manchester M13 9PL, - - 2014
In tumour xenograft experiments, treatment regimens are administered, and the tumour volume of each individual is measured repeatedly over time. Survival data are recorded because of the death of some individuals during the observation period. Also, cure data are observed because of a portion of individuals who are completely cured ...
Achard Frédéric F Joint Research Centre of the European Commission, Institute for Environment and Sustainability, TP 440, 21027, Ispra, VA, - - 2014
We estimate changes in forest cover (deforestation and forest regrowth) in the tropics for the two last decades (1990-2000 and 2000-2010) based on a sample of 4,000 units of 10km×10km size. Forest cover is interpreted from satellite imagery at 30m×30m resolution. Forest cover changes are then combined with pan-tropical biomass ...
Ni Wendy W Department of Radiology, Stanford University, Stanford, California, USA; Department of Electrical Engineering, Stanford University, Stanford, California, - - 2014
R2', the reversible component of transverse relaxation, is an important susceptibility measurement for studies of brain physiology and pathologies. In existing literature, different R2' measurement methods are used with assumption of equivalency. This study explores the choice of measurement method in healthy, young subjects at 3T. In this study, a ...
Angelis Konstantinos K Department of Genetics, Evolution and Environment, University College London, United - - 2014
The nonsynonymous/synonymous rate ratio (ω = dN/dS) is an important measure of the mode and strength of natural selection acting on nonsynonymous mutations in protein-coding genes. The simplest such analysis is the estimation of the dN/dS ratio using two sequences. Both heuristic counting methods and the maximum likelihood (ML) method ...
Schoubben Aurélie A Dipartimento di Scienze Farmaceutiche, Universit degli Studi di Perugia, Via del Liceo 1, Perugia 06123, Italy. Electronic address: - - 2014
The aim of the work was to produce inhalable capreomycin powders using a novel spray-drying technology. A 2(3) factorial design was used to individuate the best working conditions. The maximum desirability was identified at the smallest mean volume diameter (dv) and span, and the highest yield. Powders were characterized for ...
Fu Zening - - 2014
Time-varying covariance is an important metric to measure the statistical dependence between non-stationary biological processes. Time-varying covariance is conventionally estimated from short-time data segments within a window having a certain bandwidth, but it is difficult to choose an appropriate bandwidth to estimate covariance with different degrees of non-stationarity. This paper ...
Jilek K K National Radiation Protection Institute, Bartoškova 28, 140 00 Prague, Czech - - 2014
In autumn 2010, an outdoor measuring station for measurement of atmospheric radon, gamma equivalent dose rate in the range of 100 nSv h(-1)-1 Sv h(-1) and proper meteorological parameters such as thermal air gradient, relative air humidity, wind speed and direction and solar radiation intensity was built in the area ...
Bouma Andrea A Department of Food Science and Technology, Oregon State University, Corvallis - - 2014
Lack of valid economic data for artisan cheese making is a serious impediment to developing a realistic business plan and obtaining financing. The objective of this study was to determine approximate start-up and operating costs for an artisan cheese company. In addition, values are provided for the required size of ...
Rees A A Clinic for Animal Reproduction, Faculty of Veterinary Medicine, Freie Universität Berlin, Koenigsweg 65, 14163 Berlin, - - 2014
Swelling of the mammary gland is an important health status sign for clinical exploration and palpation is a routine diagnostic tool for mastitis detection in dairy cows. Data on repeatability or validity of specific methods of udder palpation are rare. The overall objective was to study the validity of estimates ...
Jain Lokesh - - 2014
The purpose of this research was to evaluate implications of choosing a statistical or biological correlation structure on model selection and parameter estimation. were performed with and without biological (weight as a common covariate) or statistical (off diagonal element in omega matrix) correlation between clearance (CL) and volume of distribution ...
Mahakkanukrauh Pasuk P Department of Anatomy, Faculty of Medicine, Chiang Mai University, 50120, - - 2014
Previous research on sex estimation from the tarsals has shown that the talus is the most sexually dimorphic tarsal bone in most populations. In order to assess the sexing potential of the talus in a Thai population, 252 skeletons (126 male, 126 female) from the Chiang Mai University Skeletal Collection ...
Arslan Hakan H Department of Agricultural Structures and Irrigation, Faculty of Agriculture, Ondokuz Mayis University, 55139, Samsun, Turkey, - - 2014
Groundwater level plays a significant role in coastal plains. Heavy pumping and excessive use of near-coast groundwater can increase the intrusion of seawater into the aquifers. In the present study, groundwater levels were measured at 59 groundwater wells at different times during pre- and post-irrigation seasons (April and September of ...
Dong Zhichao - - 2014
Numerical simulation of subaperture tool influence functions (TIF) is widely known as a critical procedure in computer-controlled optical surfacing. However, it may lack practicability in engineering because the emulation TIF (e-TIF) has some discrepancy with the practical TIF (p-TIF), and the removal rate could not be predicted by simulations. Prior ...
Orczykowska Magdalena M Łódź Univ. of Technology, Faculty of Process and Environmental Engineering, Dept. of Chemical Engineering, ul, Wólczańska 213, 90-924, Łódź, - - 2014
The effect of concentration of carbohydrates on viscoelastic properties of corn and rice starch is discussed in this paper. The texture of starch pastes was estimated using a fractional rheological linear standard solid model. Rheological parameters of the model were identified and their changes for different values of sugar concentrations ...
Cerón-Carrasco José Pedro - - 2014
Empirical parameters of solvents describing their hydrogen-bond (HB) acidity (e. g. the Kamlet-Taft α parameter) are often difficult to determine for new solvents because they are not directly related to a single definition process. Here, we propose a simple method based on one probe, the betaine dye 30, and one ...
Davies Gemma G Lancaster Environment Centre, Lancaster University, Lancaster, Lancashire, LA1 4YQ, UK. Electronic address: - - 2014
Individual exposure to air pollution depends not only upon pollution concentrations in the surrounding environment, but also on the volume of air inhaled, which is determined by an individual's physiology and activity level. This study focuses on journey-time exposure, using network analysis in a GIS environment to identify pedestrian routes ...
Piccoli Antonio A Department of Medicine, University of Padova, Padova, - - 2014
Both single-frequency bioimpedance and multiple-frequency spectroscopy are equally accurate in measuring total-body water and intracellular fluid. Estimates are consistent at a population level but not at the individual level, because of wide limits of agreement. There is no real 'gold standard' method providing estimates with absolute accuracy (in liters). Bioelectrical ...
Zhou D D Quantitative Clinical Pharmacology, AstraZeneca LP, Wilmington, DE, - - 2014
AZD7325 is a selective gamma-amino-butyric acid (GABAA )α2, 3 receptor modulator. The aims of this analysis were to develop population pharmacokinetic (PPK) models of AZD7325 and midazolam and to assess the induction effect of AZD7325 on CYP3A4 with midazolam as a substrate. Drug-drug interaction data of AZD7325 and midazolam from ...
Honda Michitaka - - 2014
Several improvements were implemented in the edge method of presampled modulation transfer function measurements (MTFs). The estimation technique for edge angle was newly developed by applying an algorithm for principal components analysis. The error in the estimation was statistically confirmed to be less than 0.01 even in the presence of ...
Stijak Lazar - - 2014
The tibial slope is one of the most frequently cited anatomical causes of anterior cruciate ligament trauma. The aim of this study was to determine the possibility of direct measuring of the tibial slope of the knee without prior soft tissue dissection in cadavers. Measurement was performed on the two ...
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