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Zühlsdorf M M Translational Innovation Platform Oncology, Merck KGaA, Darmstadt, - - 2014
Cilengitide is an αvβ3/αvβ5-integrin inhibitor investigated as an anticancer agent. This study aimed to develop a cilengitide population pharmacokinetic model using nonlinear mixed-effects modeling of 136 adult patients with advanced solid tumors and to scale the pharmacokinetic parameters to the pediatric population. A stepwise approach was used, beginning with exploratory ...
Dagne Getachew A GA a Department of Epidemiology & Biostatistics, College of Public Health , MDC 56 University of South Florida , Tampa , FL 33612 , - - 2014
ABSTRACT In a longitudinal HIV/AIDS study with response data, observations may be missing because of patient dropouts due to drug intolerance or other problems, resulting in non-ignorable missing data. In addition to non-ignorable missingness, there are also problems of skewness and left-censoring in the response variable because of a lower ...
Redman Aaron D AD ExxonMobil Biomedical Sciences, Annandale, New Jersey, - - 2014
The toxicity of chemically dispersed heavy fuel oil (HFO) and three distillate fractions to rainbow trout (Oncorhynchus mykiss) embryos was evaluated using the PETROTOX model and a biomimetic extraction (BE) technique that involved passive sampling of oil contaminated test media with solid phase microextraction (SPME) fibers. Test solutions for toxicity ...
Mukherjee Sandipan S Centre for Atmospheric Research, University of Canterbury, Christchurch, New Zealand, - - 2014
Using micrometeorological techniques to measure greenhouse gas emissions from differently treated adjacent plots is a promising avenue to verify the effect of mitigation strategies at the field scale. In pursuing such an approach, it is crucial to accurately characterize the source area of the fluxes measured at each sampling point. ...
Torrens Francisco F a Institut Universitari de Ciència Molecular , Universitat de València, Edifici d'Instituts de Paterna , València , - - 2014
The high-performance liquid-chromatographic retentions of red-wine pesticide residues are modeled by structure-property relationships. The effect of different types of features is analyzed: geometric, lipophilic, etc. The properties are fractal dimensions, partition coefficient, etc., in linear and nonlinear correlation models. Biological plastic evolution is an evolutionary perspective conjugating the effect of ...
Osher Lawrence L Professor, Kent State University College of Podiatric Medicine, Independence, OH. Electronic address: - - 2014
Several published studies have explained in detail how to measure relative metatarsal protrusion on the plain film anteroposterior pedal radiograph. These studies have demonstrated the utility of relative metatarsal protrusion measurement in that it correlates with distal forefoot deformity or pathologic features. The method currently preferred by practitioners in podiatric ...
Malinowsky Camilla C Department of Health Sciences, Occupational Therapy Luleå, Luleå University of Technology , - - 2014
Abstract Objective: Everyday technology (ET), including computers and automated telephone services, is increasingly required for everyday functioning. However, people with acquired brain injury (ABI) may have difficulty with ET use. To design interventions to support ET use, further knowledge of how to assess dimensions of such use is needed. Methods: ...
Abodinar Atiga A Department of Chemical Sciences, School of Applied Sciences, University of Huddersfield, Huddersfield HD1 3DH, - - 2014
Polysaccharides have received a great deal of attention from, for example, the food, cosmetic and pharmaceutical industries. Their conformations (flexibility/stiffness) span a wide range of conformational flexibilities with large hydrated volumes, these properties are important in relation to polysaccharide structure-function relationships. Perhaps the simplest parameter available to estimate the dilute ...
Husain Farzad - - 2014
We propose a new approach for the segmentation of 3-D point clouds into geometric surfaces using adaptive surface models. Starting from an initial configuration, the algorithm converges to a stable segmentation through a new iterative split-and-merge procedure, which includes an adaptive mechanism for the creation and removal of segments. This ...
Zollanvari Amin A Department of Electrical and Computer Engineering, Texas A&M University, College Station, TX 77843 ; Department of Statistics, Texas A&M University, College Station, TX - - 2014
The most important aspect of any classifier is its error rate, because this quantifies its predictive capacity. Thus, the accuracy of error estimation is critical. Error estimation is problematic in small-sample classifier design because the error must be estimated using the same data from which the classifier has been designed. ...
Suarez-Sipmann Fernando F aDepartment of Anesthesiology and Critical Care, Uppsala University Hospital bHedenstierna Laboratory, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden cSwisstom AG, Landquart, Switzerland dDepartment of Anesthesiology, Hospital Privado de Comunidad, Mar del Plata, - - 2014
Volumetric capnography (VCap) measures the kinetics of carbon dioxide (CO2) elimination on a breath-by-breath basis. A volumetric capnogram contains extensive physiological information about metabolic production, circulatory transport and CO2 elimination within the lungs. VCap is also the best clinical tool to measure dead spaces allowing a detailed analysis of the ...
Barty Anton A Centre for Free Electron Laser Science, Deutsches Elektronen Synchrotron DESY , Notkestrasse 85, Hamburg 22607, - - 2014
The emerging technique of serial X-ray diffraction, in which diffraction data are collected from samples flowing across a pulsed X-ray source at repetition rates of 100 Hz or higher, has necessitated the development of new software in order to handle the large data volumes produced. Sorting of data according to different ...
Bellsky Thomas T School of Mathematical and Statistical Sciences, Arizona State University, Tempe, Arizona 85287, - - 2014
This paper studies the effect of targeted observations on state and parameter estimates determined with Kalman filter data assimilation (DA) techniques. We first provide an analytical result demonstrating that targeting observations within the Kalman filter for a linear model can significantly reduce state estimation error as opposed to fixed or ...
Ji Xiaoxi X School of Mathematical Sciences and Centre for Computational Systems Biology, Fudan University, Shanghai 200433, - - 2014
This article proposes an approach to identify fractional-order systems with sparse interaction structures and high dimensions when observation data are supposed to be experimentally available. This approach includes two steps: first, it is to estimate the value of the fractional order by taking into account the solution properties of fractional-order ...
Sakhvidi Mohammad Javad Zare MJ Department of Occupational Health, Faculty of Health, Shahid Sadoughi University of Medical Sciences, Yazd, - - 2014
A cross sectional study was performed to determine the applicability and accuracy of expert judgment in occupational exposure assessment. The roles of educational session and determining factors were also realised. Thirteen occupational hygienists were divided into two groups based on their field experience. They asked to evaluate exposure intensity in ...
Möhner Matthias M Federal Institute for Occupational Safety and Health (BAuA), Berlin, - - 2014
The present study sought to examine the long-term effects of exposure to respirable dust, in particular of respirable quartz on pulmonary function. The study is based on the Wismut cohort of former uranium miners. Spirometric data, including forced expiratory volume in 1s (FEV1) and forced vital capacity (FVC) were ascertained ...
Bröcker Jochen J School of Mathematical and Physical Sciences, University of Reading, Whiteknights, P.O. Box 220, Reading RG6 6AX, United - - 2014
Estimating trajectories and parameters of dynamical systems from observations is a problem frequently encountered in various branches of science; geophysicists for example refer to this problem as data assimilation. Unlike as in estimation problems with exchangeable observations, in data assimilation the observations cannot easily be divided into separate sets for ...
Kaihara Y Y Department of Paediatric Dentistry, Hiroshima University Hospital, Hiroshima University, Hiroshima, - - 2014
Recent advances in three-dimensional imaging have led to an increased interest in the application of computer-models in paediatric dentistry. However, in evidence-based paediatric dentistry the accuracy of new methods must be validated before they are introduced to clinical practice. We aimed to compare the accuracy of measurements of digital models ...
Alves-Junior E R ER Federal University of Mato Grosso, Av Fernando Correa da Costa 2367, CEP: 78060-900, Cuiabá (MT), - - 2014
The determination of parasitemia in the diagnosis of malaria is a routine practice because it assists the selection of treatment. The techniques used for estimating parasitemia are based on leukocyte counts or on a fixed volume of blood examined in a microscopic field. This study evaluated the concordance between parasitemia ...
Labitzke D D Institute of Animal Breeding and Genetics, Hannover, - - 2014
The objectives of this study were to show whether semen traits of 30 Hanoverian stallions regularly used in AI may be useful for breeding purposes. Semen characteristics were studied using 15 149 ejaculates from 30 Hanoverian stallions of the State Stud Celle of Lower Saxony. Semen samples were collected between 2005 ...
Trojahn C C Department of Dermatology and Allergy, Clinical Research Center for Hair and Skin Science, Charité-Universitätsmedizin Berlin, Berlin, - - 2014
The non-contact optical methods phaseshift rapid in vivo measurement of skin (PRIMOS) and surface evaluation of living skin (SELS) are widely applied for measuring skin surface topography. The aims of the present study were to evaluate reliability and validity of these methods and to compare skin roughness intraindividually. SELS and ...
Moura Daniel C DC Instituto de Telecomunicações, Departamento de Engenharia Electrotécnica e de Computadores, Faculdade de Engenharia, Universidade do Porto, Porto, Portugal. Electronic address: - - 2014
This paper presents a new method for modelling the spines of subjects and making accurate 3D measurements using standard radiologic systems without requiring calibration objects. The method makes use of the focal distance and statistical models for estimating the geometrical parameters of the system. A dataset of 32 subjects was ...
Lin Liang - - 2014
Although it has been widely discussed in video surveillance, background subtraction is still an open problem in the context of complex scenarios, e.g., dynamic backgrounds, illumination variations, and indistinct foreground objects. To address these challenges, we propose an effective background subtraction method by learning and maintaining an array of dynamic ...
Gallagher Andrew A Centre for Anthropological Research (CAfR), University of Johannesburg, Auckland Park 2006, Johannesburg, South Africa. Electronic address: - - 2014
Eurasian Neandertals encompass the entire observed range of recent and fossil Homo sapiens in absolute, but not relative endocranial volume, and Neandertals attest an average EQ significantly lower than their Upper Pleistocene successors. While the cognitive, social, and evolutionary implications of this phenomenon have been emphasised, the statistical basis of ...
Cheung Tyler T Cedars Sinai Medical Center, Department of Neurology, Los Angeles, - - 2014
Objective: To create a data-driven computational model that identifies brain regions most frequently influenced by successful deep brain stimulation (DBS) of the globus pallidus (GP) for advanced, medication-resistant, generalized dystonia. Methods: We studied a retrospective cohort of 21 DYT1+ primary dystonia patients treated for at least 1 year with bilateral ...
Yu Zhou Z Goethe University Frankfurt, Buchmann Institute for Molecular Life Sciences and Institute for Biophysics, Max-von-Laue Str.15, 60438 Frankfurt am - - 2014
Cryo-electron tomography provides a snapshot of the cellular proteome. With template matching, the spatial positions of various macromolecular complexes within their native cellular context can be detected. However, the growing awareness of the reference bias introduced by the cross-correlation based approaches, and more importantly the lack of a reliable confidence ...
Jewell Albert J AJ Glyndŵr University, Mold Road, Wrexham, Wales LL11 2AW UK. Electronic address: - - 2014
Lars Tornstam's attractive theory that there is an ultimate developmental stage that is the perquisite of the very old has caused controversy and generated a large volume of literature. In this article, Tornstam's threefold categorisation of gerotranscendence (cosmic, coherence and solitude) and the relationship of his model with that of ...
Bergman Elad E Department of Biomedical Engineering, The Iby and Aladar Fleischman Faculty of Engineering, Tel Aviv University, Tel Aviv 69978, - - 2014
Unilateral NMR devices are valuable tools used to study non-invasively arbitrarily-sized objects. They have been utilized in various applications, including non-destructive testing and well logging. However, measurements with such scanners are characterized by a low sensitivity, which is mainly the result of the low and inhomogeneous magnetic field B0. The ...
Bohlken Marc M MM University Medical Center Utrecht-Brain Center Rudolf Magnus, Utrecht, The - - 2014
Individual variation in structural brain network topology has been associated with heritable behavioral phenotypes such as intelligence and schizophrenia, making it a candidate endophenotype. However, little is known about the genetic influences on individual variation in structural brain network topology. Moreover, the extent to which structural brain network topology overlaps ...
Jameson Michael G MG Liverpool and Macarthur Cancer Therapy Centres, Australia; Centre for Medical Radiation Physics, University of Wollongong, Australia; Ingham Institute of Applied Medical Research, Australia. Electronic address: - - 2014
Contouring variation is a well know uncertainty in modern radiotherapy. This study investigates the relationship between contouring variation, tumor control probability (TCP) and equivalent uniform dose (EUD) for conformal non-small cell lung cancer (NSCLC) radiotherapy. Seven patients were retrospectively recruited to the study and multiple PTV contours were generated based ...
Huizer Daan D Department of Environmental Science, Institute for Water and Wetland Research, Faculty of Science, Radboud University Nijmegen, PO Box 9010, 6500 GL Nijmegen, The Netherlands; Caesar Consult Nijmegen, PO Box 31070, 6503 CB Nijmegen, The Netherlands. Electronic address: - - 2014
The coherence between occupational exposure limits (OELs) and their corresponding biological limit values (BLVs) was evaluated for 2-propanol and acetone. A generic human PBPK model was used to predict internal concentrations after inhalation exposure at the level of the OEL. The fraction of workers with predicted internal concentrations lower than ...
Davda Jasmine P JP 1Amgen Inc. Pharmacokinetics and Drug Metabolism; Seattle, WA, South San Francisco, CA, and Thousand Oaks, CA - - 2014
The objectives of this retrospective analysis were (1) to characterize the population pharmacokinetics (popPK) of four different monoclonal antibodies (mAbs) in a combined analysis of individual data collected during first-in-human (FIH) studies and (2) to provide a scientific rationale for prospective design of FIH studies with mAbs. The data set ...
Liz Martins Margarida M Faculty of Food Science and Nutrition, University of Porto, Rua Dr. Roberto Frias, 4200-465 Porto, Portugal. Electronic address: - - 2014
The aim of this study was to validate the visual estimation method for aggregated plate waste of main dish at Portuguese primary school canteens. For this purpose plate waste at school lunch was measured for 505 individual servings, using weighing individual servings and plate waste and visual estimation method by ...
Du Cheng Fei CF Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, National Key Lab of Virtual Reality Technology, Beihang University, 100191, Beijing, - - 2014
The aim of this study is to investigate the dynamic response of a multi-segment model of the thoracolumbar spine and determine how the sitting posture affects the response under the impact of ejection. A nonlinear finite element model of the thoracolumbar-pelvis complex (T9-S1) was developed and validated. A multi-body dynamic ...
Williams D J DJ Department of Anaesthetics, Abertawe Bro Morgannwg University NHS Trust, Morriston Hospital, Swansea, - - 2014
Toxic dose limits (mg.kg(-1) ) for local anaesthetics based on body weight are well-established, but calculation of the maximum safe volume (ml) of a given agent and formulation is complex, and frequently results in errors. We therefore developed a nomogram to perform this calculation. We compared the performance of the ...
Skrobala Agnieszka A Department of Electroradiology, University of Medical Science, Poznan, Poland; Department of Medical Physics, Greater Poland Cancer Centre, Poznan, Poland. Electronic address: - - 2014
To investigate the feasibility of using an artificial neural network (ANN) to generate beam orientations in stereotactic radiosurgery (SRS). A dataset of 669 intracranial lesions was used to build, train, and validate three ANNs. In ANN1, Cartesian coordinates described the localization of the PTV and OARs. In ANN2, a genetic ...
Shang Yu Y Department of Biomedical Engineering, University of Kentucky, Lexington, Kentucky 40506, - - 2014
Conventional semi-infinite solution for extracting blood flow index (BFI) from diffuse correlation spectroscopy (DCS) measurements may cause errors in estimation of BFI (αDB ) in tissues with small volume and large curvature. We proposed an algorithm integrating Nth-order linear model of autocorrelation function with the Monte Carlo simulation of photon ...
Samplaski Mary K MK Division of Urology, Department of Surgery, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, - - 2014
To formulate nomograms based on pre-repair characteristics to predict improvements in semen parameters after varicocele repair. Model using multivariable linear regression based on prospectively collected database, with performance was quantified by concordance correlation coefficient and Pearson correlation coefficient after internal validation with bootstrapping. A male infertility specialty clinic. Men presenting ...
Ssenyonga Taddeo - - 2014
Aerosols affect the climate directly through absorption and reflection of sunlight back to space and indirectly by acting as cloud condensation nuclei. This paper is based on more than three decades of satellite data (1979-1994 and 1996-2012) from total ozone mapping spectrometer (TOMS) and ozone monitoring instrument (OMI), which have ...
Johansson Asa M AM Pharmacometrics Research Group, Department of Pharmaceutical Biosciences, Uppsala University, P.O. Box 591, 751 24 , Uppsala, - - 2014
NONMEM is the most widely used software for population pharmacokinetic (PK)-pharmacodynamic (PD) analyses. The latest version, NONMEM 7 (NM7), includes several sampling-based estimation methods in addition to the classical methods. In this study, performance of the estimation methods available in NM7 was investigated with respect to bias, precision, robustness and ...
Takezawa Kentaro K 1Osaka University Graduate School of - - 2014
Various animal models have been used in research into bladder dysfunction, and in vivo cystometry is a common method to analyze bladder function in animals. However, it is rather difficult to perform reliably in small animals. Transabdominal bladder ultrasonography combined with cystometry in urethane-anesthetized mice have revealed physical inhibition of ...
Girard Gabriel G Sherbrooke Connectivity Imaging Lab (SCIL), Computer Science Department, Faculty of Science, Université de Sherbrooke, 2500 Boulevard Université, Sherbrooke, QC, Canada J1K 2R1; Project Team Athena, INRIA Sophia Antipolis Méditerranée, 2004 Route des Lucioles BP 93, 06902 Sophia Antipolis Cedex, France. Electronic address: - - 2014
Diffusion MRI tractography is often used to estimate structural connections between brain areas and there is a fast-growing interest in quantifying these connections based on their position, shape, size and length. However, a portion of the connections reconstructed with tractography is biased by their position, shape, size and length. Thus, ...
Wu Tim T Auckland Bioengineering Institute, The University of Auckland, Auckland, New - - 2014
A detailed biomechanical model of the human face driven by a network of muscles is a useful tool in relating the muscle activities to facial deformations. However, lengthy computational times often hinder its applications in practical settings. The objective of this study is to replace precise but computationally demanding biomechanical ...
Kounina Anna A Ecole Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland; Quantis, Parc scientifique EPFL, Bâtiment D, 1015 Lausanne, Switzerland. Electronic address: - - 2014
This paper develops continent-specific factors for the USEtox model and analyses the accuracy of different model architectures, spatial scales and archetypes in evaluating toxic impacts, with a focus on freshwater pathways. Inter-continental variation is analysed by comparing chemical fate and intake fractions between sub-continental zones of two life cycle impact ...
Parker Andrew S AS Department of Orthopedic Surgery, Baylor College of Medicine, Ben Taub General Hospital, Houston, TX; Dan L. Duncan Institute for Clinical and Translational Research, Baylor College of Medicine, Houston, TX; Department of Radiology, Baylor College of Medicine, Houston, - - 2014
To determine the reliability of measuring ulnar variance on lateral wrist radiographs and to compare this technique with previously described methods. Ulnar variance was measured in 100 normal wrist radiographs using the methods of perpendiculars, central reference point, and the lateral radiograph by 3 surgeons on 2 occasions. Intraobserver repeatability ...
Paul Sudhir S Department of Mathematics and Statistics, Trent University, Peterborough, Ontario, K9J7B8, - - 2014
Longitudinal (clustered) response data arise in many bio-statistical applications which, in general, cannot be assumed to be independent. Generalized estimating equation (GEE) is a widely used method to estimate marginal regression parameters for correlated responses. The advantage of the GEE is that the estimates of the regression parameters are asymptotically ...
Frątczak Katarzyna K Laboratory of Criminalistics, Adam Mickiewicz University, Św. Marcin 90, 61-809 Poznań, Poland; Department of Animal Taxonomy and Ecology, Adam Mickiewicz University, Umultowska 89, 61-614 Poznań, - - 2014
In order to estimate postmortem interval from immature insects, it is necessary to accurately determine which instars are present in a corpse sample. Unfortunately, most forensically useful beetles lack morphological features specific for particular instars, and the only way to distinguish larval instars of particular species is to measure their ...
Day Lukejohn W LW Division of Gastroenterology, San Francisco General Hospital and Trauma Center, San Francisco, California, USA; GI Health Outcomes, Policy and Economics (HOPE) Research Program and Center for Innovation in Access and Quality (CIAQ), Department of Medicine, University of California, San Francisco, California, - - 2014
Improvements in endoscopy center efficiency are needed, but scant data are available. To identify opportunities to improve patient throughput while balancing resource use and patient wait times in a safety-net endoscopy center. Safety-net endoscopy center. Outpatients undergoing endoscopy. A time and motion study was performed and a discrete event simulation ...
Kaduk Mateusz M Biosystems Data Analysis, Swammerdam Institute for Life Sciences, University of Amsterdam, Science Park 904, 1098 XH Amsterdam, The Netherlands; Netherlands Metabolomics Centre, Leiden, The - - 2014
Modern chromatography-based metabolomics measurements generate large amounts of data in the form of abundances of metabolites. An increasingly popular way of representing and analyzing such data is by means of association networks. Ideally, such a network can be interpreted in terms of the underlying biology. A property of chromatography-based metabolomics ...
Rose Matthias M Department of Quantitative Health Sciences, University of Massachusetts Medical School, Worcester, MA, USA; Department of Psychosomatic Medicine, Medical School, Charité Universitätsmedizin Berlin, Berlin, Germany. Electronic address: - - 2014
To document the development and psychometric evaluation of the Patient-Reported Outcomes Measurement Information System (PROMIS) Physical Function (PF) item bank and static instruments. The items were evaluated using qualitative and quantitative methods. A total of 16,065 adults answered item subsets (n>2,200/item) on the Internet, with oversampling of the chronically ill. ...
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