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Tange Julie I JI Department of Laboratory Medicine and Pathology, Mayo Clinic Rochester, - - 2013
Warfarin dosing relies on accurate measurements of international normalized ratio (INR), which is calculated from the prothrombin time (PT), International Sensitivity Index international sensitivity index (ISI) of the thromboplastin, and the geometric mean of normal PT (MNPT). However, ISI assignments of certain reagent/instrument combinations are frequently unavailable, especially when the ...
McMurphy Timothy B TB Department of Biomedical Materials Science, University of Mississippi Medical Center, Jackson, MS, - - 2013
To develop a method, which is precise, accurate, and insensitive to the angle of inclination for determining the fractal dimensional increment (D*) of a surface. Brownian interpolation was used to generate simulated ceramic fracture surfaces having known D* values of 0.1, 0.2, 0.3, and 0.4 with 10 surfaces at each ...
Liang Tai-Ran TR Department of Physics, Nankai University, Tianjin 300071, - - 2013
The Chinese spallation neutron source (CSNS) is a high-performance pulsed neutron source, having 20 neutron beamlines for neutron scattering instruments. The shielding design of these beamlines is usually needed for Monte Carlo (MC) calculation, and the use of variance reduction methods is critical to carrying out an efficient, reliable MC ...
Brehm Wolfgang W Department of Biology, Universität Konstanz, Box 647, 78457 Konstanz, - - 2014
In serial crystallography, a very incomplete partial data set is obtained from each diffraction experiment (a `snapshot'). In some space groups, an indexing ambiguity exists which requires that the indexing mode of each snapshot needs to be established with respect to a reference data set. In the absence of such ...
Debin Marion - - 2013
Assessing the accuracy of influenza epidemic periods determined by statistical models is important to improve the performance of algorithms used in real-time syndromic surveillance systems. This is a difficult problem to address in the absence of a reliable gold standard. The objective of this study is to establish an expert-based ...
Unal Yavuz Y Education Faculty, Amasya University, Amasya, - - 2014
In this paper, an innovative data pre-processing method to improve the classification performance and to determine automatically the vertebral column disorders including disk hernia (DH), spondylolisthesis (SL) and normal (NO) groups has been proposed. In the classification of vertebral column disorders' dataset with three classes, a pairwise fuzzy C-means (FCM) ...
Göhring Janett J Max F. Perutz Laboratories, Medical University of Vienna, Vienna 1030, Austria, Gregor Mendel Institute, Vienna 1030, Austria, Institute for Applied Physics, Johannes Kepler University Linz, Linz 4040, Austria and Upper Austria University of Applied Sciences, Campus Linz, Linz 4020, - - 2013
Telomeres comprise the protective caps of natural chromosome ends and function in the suppression of DNA damage signaling and cellular senescence. Therefore, techniques used to determine telomere length are important in a number of studies, ranging from those investigating telomeric structure to effects on human disease. Terminal restriction fragment (TRF) ...
Gentsch Lydia L Institute of Agricultural Sciences, ETH Zurich, Universitatsstrasse 2, 8092 Zurich, Switzerland; INRA, UR1263 Ephyse, 33140 Villenave d'Ornon, - - 2013
Field measurements of photosynthetic carbon isotope discrimination ((13) Δ) of Fagus sylvatica, conducted with branch bags and laser spectrometry, revealed a high variability of (13) Δ, both on diurnal and day-to-day timescales. We tested the prediction capability of three versions of a commonly-used model for (13) Δ [called here comprehensive ...
Xu Wenxiang W Institute of Soft Matter Mechanics, College of Mechanics and Materials, Hohai University, Nanjing 210098, China. - - 2013
The effect of microstructures of interfacial layers on transport behaviors of particulate composites has been found to be significant, thus microstructural characteristics of interfacial layers should be considered in the analysis for better prediction of transport properties of particulate composites. However, it is very difficult to determine the volume fraction ...
Tellinghuisen Joel J Department of Chemistry, Vanderbilt University, Nashville, Tennessee, USA 37235. Electronic address: - - 2013
New methods are used to compare seven qPCR analysis methods for their performance in estimating the quantification cycle (Cq) and amplification efficiency (E) for a large test data set (94 samples for each of 4 dilutions) from a recent study. Precision and linearity are assessed using chi-square (χ2), which is ...
Berivanlou Nima Hemmati NH Control and Intelligent Processing Center of Excellence, School of Electrical and Computer Engineering, College of Engineering, University of Tehran, Tehran, - - 2013
The quality of the functional near infrared spectroscopy (fNIRS) recordings is highly degraded by the presence of physiological interferences. It is crucial to efficiently separate the evoked hemodynamic responses (EHRs) from other background hemodynamic activities prior to any further processing. This paper presents a novel algorithm for physiological interferences reduction ...
Greve Douglas N DN Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, - - 2013
Exploratory (i.e., voxelwise) spatial methods are commonly used in neuroimaging to identify areas that show an effect when a region-of-interest (ROI) analysis cannot be performed because no strong a priori anatomical hypothesis exists. However, noise at a single voxel is much higher than noise in a ROI making noise management ...
Eder Maximilian M Research Group CAPS-Computer Aided Plastic Surgery, Department of Plastic Surgery and Hand Surgery, Klinikum rechts der Isar, Technische Universität München, Ismaninger Str. 22, 81675, Munich, - - 2013
Biomechanical breast modeling using finite element (FE) analysis to predict 3-D breast deformations is of interest for various biomedical applications. Currently no consensus of reliable magnitudes of mechanical breast tissue properties exists. We therefore applied 12 material properties proposed in the literature to FE simulation models derived from prone MRI ...
Sinha Samiran S Department of Statistics, Texas A&M University, College Station, Texas 77843-3143, - - 2013
We take a semiparametric approach in fitting a linear transformation model to a right censored data when predictive variables are subject to measurement errors. We construct consistent estimating equations when repeated measurements of a surrogate of the unobserved true predictor are available. The proposed approach applies under minimal assumptions on ...
Schneider D D Clinic of Fixed and Removable Prosthodontics and Dental Material Science, Center of Dental Medicine, University of Zurich, - - 2013
The use of periodontal probes harbors the risk of measurement errors. The aim of this study was to investigate the accuracy of the digital determination of gingival recession and papilla height on virtual jaw models, given the hypothesis that they show lower intrarater and interrater variability than conventional linear measurements ...
McGinitie Teague M TM Department of Chemistry, University of Alberta, Edmonton, Alberta, T6G2G2, - - 2013
A new method for estimating the thermodynamic parameters of ΔH(T0), ΔS(T0), and ΔCP for use in thermodynamic modeling of GC×GC separations has been developed. The method is an alternative to the traditional isothermal separations required to fit a three-parameter thermodynamic model to retention data. Herein, a non-linear optimization technique is ...
Prudhomme Christel C Centre for Ecology and Hydrology, Wallingford OX10 8BB, United - - 2013
Increasing concentrations of greenhouse gases in the atmosphere are expected to modify the global water cycle with significant consequences for terrestrial hydrology. We assess the impact of climate change on hydrological droughts in a multimodel experiment including seven global impact models (GIMs) driven by bias-corrected climate from five global climate ...
Hero Robert R University of California, Davis, - - 2013
In this paper, we present a high quality and interactive method for volume rendering curvilinear-grid datasets. This method is based on a two-stage parallel transformation of the sample position into intermediate computational space then into texture space through the use of multiple 1 and 2D deformation textures using hardware acceleration. ...
Dwyer Michael G MG Buffalo Neuroimaging Analysis Center, Department of Neurology, School of Medicine and Biomedical Science, University at Buffalo, State University of New York, Buffalo, NY, USA. Electronic address: - - 2013
SIENA and similar techniques have demonstrated the utility of performing "direct" measurements as opposed to post-hoc comparison of cross-sectional data for the measurement of whole brain (WB) atrophy over time. However, gray matter (GM) and white matter (WM) atrophy are now widely recognized as important components of neurological disease progression, ...
Murad Havi H 1Biostatistics Unit, Gertner Institute for Epidemiology and Health Policy Research, Tel-Hashomer, - - 2013
Assessing interactions in linear regression models when covariates have measurement error (ME) is complex.We previously described regression calibration (RC) methods that yield consistent estimators and standard errors for interaction coefficients of normally distributed covariates having classical ME. Here we extend normal based RC (NBRC) and linear RC (LRC) methods to ...
Grabowski T - - 2013
Regulatory agencies do not specify how to plan the sampling intervals in pharmacokinetics (PK) studies. Every interval between each sampling point forms one of the fractions of the area under the curve (AUC). The aim of this study is to propose a method of qualitative evaluation of PK studies, on ...
Hirve Siddhivinayak S Vadu Rural Health Program, KEM Hospital Research Center, Pune, India; Umeå Centre for Global Health Research, Division of Epidemiology and Global Health, Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden. Electronic address: - - 2013
We compared prevalence estimates of self-rated health (SRH) derived indirectly using four different small area estimation methods for the Vadu (small) area from the national Study on Global AGEing (SAGE) survey with estimates derived directly from the Vadu SAGE survey. The indirect synthetic estimate for Vadu was 24% whereas the ...
Kuhlmann Levin - - 2013
Bayesian spiking neurons (BSNs) provide a probabilistic interpretation of how neurons perform inference and learning. Online learning in BSNs typically involves parameter estimation based on maximum-likelihood expectation-maximization (ML-EM) which is computationally slow and limits the potential of studying networks of BSNs. An online learning algorithm, fast learning (FL), is presented ...
Chen Baojiang - - 2013
In statistical analysis, a regression model is needed if one is interested in finding the relationship between a response variable and covariates. When the response depends on the covariate, then it may also depend on the function of this covariate. If one has no knowledge of this functional form but ...
Grosswendt B - - 2013
The track nanodosemeter developed at the National Laboratories of Legnaro (LNL), Italy allows the direct investigation of the properties of particle tracks, by measuring ionisation-cluster-size distributions caused by ionising particles within a 'nanometre-sized' target volume while passing it at a well-specified impact parameter. To supplement the measurements, a dedicated Monte ...
Caruel M - - 2013
Complex 3D beating heart models are now available, but their complexity makes calibration and validation very difficult tasks. We thus propose a systematic approach of deriving simplified reduced-dimensional models, in "0D"-typically, to represent a cardiac cavity, or several coupled cavities-and in "1D"-to model elongated structures such as muscle samples or ...
Brocchini Maurizio M D.I.C.E.A. , Università Politecnica delle Marche , Via Brecce Bianche 12, 60131 Ancona, - - 2013
This paper, which is largely the fruit of an invited talk on the topic at the latest International Conference on Coastal Engineering, describes the state of the art of modelling by means of Boussinesq-type models (BTMs). Motivations for using BTMs as well as their fundamentals are illustrated, with special attention ...
Wang Kun - - 2013
Lopinavir (LPV)/ritonavir (RTV) co-formulation (LPV/RTV) is a widely used protease inhibitor (PI)-based regimen to treat HIV-infection. As with all PIs, the trough concentration (C trough) is a primary determinant of response, but the optimum exposure remains poorly defined. The primary objective was to develop an integrated LPV population pharmacokinetic model ...
Dutra José Diogo L - - 2013
In this study, we propose three different methods for calculation of Judd-Ofelt intensity parameters of poly-europium systems. The first, named Centroid Method, proposes the calculation considering the center of the dimeric system as the half distances between the two europium centers. The second method, called Overlapped Polyhedra Method, proposes the ...
Wagner S - - 2013
Objective. We investigate volume conduction effects in transcranial direct current stimulation (tDCS) and present a guideline for efficient and yet accurate volume conductor modeling in tDCS using our newly-developed finite element (FE) approach. Approach. We developed a new, accurate and fast isoparametric FE approach for high-resolution geometry-adapted hexahedral meshes and ...
Redal-Baigorri Belén - - 2013
Estimation of Glomerular Filtration Rate (GFR) by equations such as Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) or Modification of Diet in Renal Disease (MDRD) is usually expressed as a Body Surface Area (BSA) indexed value (ml/min per 1.73 m2). This can have severe clinical consequences in patients with extreme body ...
Rai Mahendra Kumar MK Department of Biotechnology, S. G. B. Amravati University, Amravati, 444 602 Maharashtra - - 2014
Phoma is a highly polyphyletic genus with its unclear species boundaries. The conventional system of identification is functional but it has its limitations. Besides morphological studies, chemotaxonomy, secondary metabolite and protein profiling have been assessed for the classification and identification of these fungi. Molecular datasets have provided a better outlook ...
Camacho A A Institut de Tècniques Energètiques, Universitat Politècnica de Catalunya, Avda. Diagonal, 647, 08028 Barcelona, Spain. Electronic address: - - 2013
The activities on air filters of the radionuclides (40)K and (137)Cs were measured in an above ground laboratory and compared with the activities measured in an underground laboratory. The average relative differences were lower than 20% for (137)Cs and (40)K. The temporal series of these radionuclides in the period 2006-2010 ...
Charman W Neil WN Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, - - 2013
Lens average and equivalent refractive indices are required for purposes such as lens thickness estimation and optical modeling. We modeled the refractive index gradient as a power function of the normalized distance from lens center. Average index along the lens axis was estimated by integration. Equivalent index was estimated by ...
Yuan Xiaoru - - 2013
For high-dimensional data, this work proposes two novel visual exploration methods to gain insights into the data aspect and the dimension aspect of the data. The first is a Dimension Projection Matrix, as an extension of a scatterplot matrix. In the matrix, each row or column represents a group of ...
Hsu Wei-Hsien - - 2013
We present an integrated camera motion design and path generation system for building volume data animations. Creating animations is an essential task in presenting complex scientific visualizations. Existing visualization systems use an established animation function based on keyframes selected by the user. This approach is limited in providing the optimal ...
Khlebnikov Rostislav - - 2013
Analysis of multivariate data is of great importance in many scientific disciplines. However, visualization of 3D spatially-fixed multivariate volumetric data is a very challenging task. In this paper we present a method that allows simultaneous real-time visualization of multivariate data. We redistribute the opacity within a voxel to improve the ...
Martínez-Rego David - - 2013
A technique for adjusting a minimum volume set of covering ellipsoids technique is elaborated. Solutions to this problem have potential application in one-class classification and clustering problems. Its main original features are: 1) It avoids the direct evaluation of determinants by using diagonalization properties of the involved matrices, 2) it ...
Mukherjee Ryan - - 2013
We describe and compare several methods for recovering endocardial walls from 3-D transesophageal echocardiography (3-D TEE), which can help with diagnostics or providing input into biomechanical models. We employ a segmentation method based on 3-D level sets that maximizes enclosed volume while minimizing surface area and uses a growth inhibition ...
Shi Yue - - 2013
To present a predictive model of the registration tolerance for wavefront-guided correction to maintain acuity within fixed limits and demonstrate the potential utility using two typical keratoconic eyes. Change in log visual Strehl was plotted as a function of translation error for a series of rotations of a wavefront-guided correction. ...
Canavesi Cristina - - 2013
We propose a fast algorithm to estimate the flux collected by conic reflector patches, based on the calculation of intersections between neighboring patches. The algorithm can be employed in conjunction with the supporting ellipsoids algorithm for freeform reflector design and is shown to be orders of magnitude faster and more ...
Huang Yijian Y Department of Biostatistics and Bioinformatics, Emory - - 2013
Weighted log-rank estimating function has become a standard estimation method for the censored linear regression model, or the accelerated failure time model. Well established statistically, the estimator defined as a consistent root has, however, rather poor computational properties because the estimating function is neither continuous nor, in general, monotone. We ...
Mageed Mahmoud M Large Animal Clinic for Surgery, Faculty of Veterinary Medicine, University of Leipzig, Leipzig, Germany. ; Department of Surgery and Anaesthesia, Faculty of Veterinary Medicine, University of Khartoum, Khartoum North, - - 2013
Sheep are commonly used as a model for human spinal orthopaedic research due to their similarity in morphological and biomechanical features. This study aimed to document the volumes of vertebral bodies and compare the generated results as well as morphometry of the sheep lumbar spine to human published data. For ...
Kang Le L Center for Devices and Radiological Health, US Food and Drug Administration, Silver Spring, MD 20993, United - - 2013
With three ordinal diagnostic categories, the most commonly used measures for the overall diagnostic accuracy are the volume under the ROC surface (VUS) and partial volume under the ROC surface (PVUS), which are the extensions of the area under the ROC curve (AUC) and partial area under the ROC curve ...
Lindenstrand David - - 2013
Data, on the number of infected, gathered from a large epidemic outbreak can be used to estimate parameters related to the strength and speed of the spread. The Malthusian parameter, which determines the initial growth rate of the epidemic is often of crucial interest. Using a simple epidemic SEIR model ...
Panagiotou E E Department of Mathematics, University of California, Santa Barbara, California 93106, - - 2013
We propose a method to estimate N_{e}, the entanglement length, that incorporates both local and global topological characteristics of chains in a melt under equilibrium conditions. This estimate uses the writhe of the chains, the writhe of the primitive paths, and the number of kinks in the chains in a ...
Bo Shen - - 2013
In this paper, the H∞ state estimation problem is investigated for a class of complex networks with uncertain coupling strength and incomplete measurements. With the aid of the interval matrix approach, we make the first attempt to characterize the uncertainties entering into the inner coupling matrix. The incomplete measurements under ...
Yu Yao Y Department of Biostatistics and Computational Biology, University of Rochester, NY 14642, - - 2013
This paper is concerned with model selection and model averaging procedures for partially linear single-index models. The profile least squares procedure is employed to estimate regression coefficients for the full model and submodels. We show that the estimators for submodels are asymptotically normal. Based on the asymptotic distribution of the ...
Hornik Kurt K Institute for Statistics and Mathematics, WU Wirtschaftsuniversität Wien, Augasse 2-6, 1090 Vienna, - - 2013
We systematically investigate lower and upper bounds for the modified Bessel function ratio [Formula: see text] by functions of the form [Formula: see text] in case [Formula: see text] is positive for all [Formula: see text], or equivalently, where [Formula: see text] or [Formula: see text] is a negative integer. ...
Beyer Johanna J King Abdullah University of Science and - - 2013
This paper presents ConnectomeExplorer, an application for the interactive exploration and query-guided visual analysis of large volumetric electron microscopy (EM) data sets in connectomics research. Our system incorporates a knowledge-based query algebra that supports the interactive specification of dynamically evaluated queries, which enable neuroscientists to pose and answer domain-specific questions ...
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