Search Results
Results 1 - 50 of 3338
1 2 3 4 5 6 7 8 9 10 >
Russell Sara S SS Natural History Museum, Cromwell Road, London SW7 5BD, UK - - 2014
The lunar magma ocean model is a well-established theory of the early evolution of the Moon. By this model, the Moon was initially largely molten and the anorthositic crust that now covers much of the lunar surface directly crystallized from this enormous magma source. We are undertaking a study of ...
Addison Paul S PS Advanced Research Group, Covidien Respiratory and Monitoring Solutions, The Technopole Centre, Edinburgh, EH26 0PJ, Scotland, UK, - - 2014
DPOP (∆POP or Delta-POP) is a non-invasive parameter which measures the strength of respiratory modulations present in the pulse oximetry photoplethysmogram (pleth) waveform. It has been proposed as a non-invasive surrogate parameter for pulse pressure variation (PPV) used in the prediction of the response to volume expansion in hypovolemic patients. ...
Bruser Christoph - - 2014
Unobtrusive, long-term monitoring of cardiac (and respiratory) rhythms using only non-invasive vibration sensors mounted in beds promises to unlock new applications in home and low acuity monitoring. This paper presents a novel concept for such a system based on an array of near infrared (NIR) sensors placed underneath a regular ...
Oweis Rami J RJ Biomedical Engineering Department, Faculty of Engineering, Jordan University of Science and Technology, Irbid, - - 2014
Background: Computerized lung sound analysis involves recording lung sound via an electronic device, followed by computer analysis and classification based on specific signal characteristics as non-linearity and nonstationarity caused by air turbulence. An automatic analysis is necessary to avoid dependence on expert skills. Methods: This work revolves around exploiting autocorrelation ...
Li Bangde B Sensory Evaluation Center, College of Agricultural Sciences, The Pennsylvania State University, University Park, Pennsylvania, USA ; Department of Food Science, College of Agricultural Sciences, The Pennsylvania State University, University Park, Pennsylvania, - - 2014
Designed experiments provide product developers feedback on the relationship between formulation and consumer acceptability. While actionable, this approach typically assumes a simple psychophysical relationship between ingredient concentration and perceived intensity. This assumption may not be valid, especially in cases where perceptual interactions occur. Additional information can be gained by considering ...
Mauderly Joe L JL Lovelace Respiratory Research Institute , Albuquerque, NM , - - 2014
Abstract The National Environmental Respiratory Center Program was initiated as an experiment to explore strategies for identifying the components of complex air pollution mixtures that cause health effects associated statistically with air pollution. A strategy involving multivariate analysis of a composition-concentration-response database was adopted. A novel database was created by ...
Rankin Scott A SA Division of Developmental Biology, College of Medicine University of Cincinnati, Cincinnati, OH, - - 2014
Background: Respiratory system development is regulated by a complex series of endoderm - mesoderm interactions that are not fully understood. Recently Xenopus has emerged as an alternative model to investigate early respiratory system development, but the extent to which the morphogenesis and molecular pathways involved are conserved between Xenopus and ...
Winquist Andrea A Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, Georgia, - - 2014
Elemental carbon (EC) and organic carbon (OC) represent a substantial portion of particulate matter <2.5 μm in diameter (PM2.5), and have been associated with adverse health effects. EC and OC are commonly measured using the National Institute of Occupational Safety and Health (NIOSH) method or the Interagency Monitoring of Protected Visual ...
Johnson Blair T BT a University of Connecticut , Storrs , Connecticut , United - - 2014
Abstract Background: Systematic reviews now routinely assess methodological quality to gauge the validity of the included studies and of the synthesis as a whole. Although trends from higher quality studies should be clearer, it is uncertain how often meta-analyses incorporate methodological quality in models of study results either as predictors, ...
Roelen Corné A M CA ArboNed Occupational Health Service, PO Box 85091, 3508 AB, Utrecht, The Netherlands, - - 2014
Purpose To validate Dutch prognostic models including age, self-rated health and prior sickness absence (SA) for ability to predict high SA in Danish eldercare. The added value of work environment variables to the models' risk discrimination was also investigated. Methods 2,562 municipal eldercare workers (95 % women) participated in the Working ...
Keil Alexander P AP From the aDepartment of Epidemiology, University of North Carolina, Chapel Hill, NC; and bDepartment of Epidemiology, Biostatistics, and Occupational Health, McGill University, Montréal, Québec, - - 2014
The parametric g-formula can be used to estimate the effect of a policy, intervention, or treatment. Unlike standard regression approaches, the parametric g-formula can be used to adjust for time-varying confounders that are affected by prior exposures. To date, there are few published examples in which the method has been ...
Chen Renjie - - 2014
Previous studies in East Asia have revealed that the short-term associations between tropospheric ozone and daily mortality rate were strongest in winter, which is opposite to the findings in North America and Western Europe. Therefore, we investigated the season-varying association between ozone and daily mortality rate in 21 cities of ...
Naimi Ashley I AI From the aDepartment of Obstetrics and Gynecology, McGill University, Montreal, Quebec, Canada; bDepartment of Epidemiology, Biostatistics, and Occupational Health, McGill University, Montreal, Quebec, Canada; and cInstitut national de santé publique du Québec, Montreal, Quebec, - - 2014
Exposure-response curves are central to understanding how continuous exposures relate to health outcomes. Common methods to plot such curves include the use of crude and adjusted regression, with the exposure specified using fractional polynomials or regression splines. These approaches are subject to important limitations. In this article, we illustrate the ...
Perin J J Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe St, Baltimore, Maryland 21205, - - 2014
Semi-parametric regression models for the joint estimation of marginal mean and within-cluster pairwise association parameters are used in a variety of settings for population-averaged modeling of multivariate categorical outcomes. Recently, a formulation of alternating logistic regressions based on orthogonalized, marginal residuals has been introduced for correlated binary data. Unlike the ...
Wittemyer George G Department of Fish, Wildlife, and Conservation Biology andSave the Elephants, Nairobi, Kenya 00200;Graduate Degree Program in Ecology, Colorado State University, Ft. Collins, CO 80523-1474; - - 2014
Illegal wildlife trade has reached alarming levels globally, extirpating populations of commercially valuable species. As a driver of biodiversity loss, quantifying illegal harvest is essential for conservation and sociopolitical affairs but notoriously difficult. Here we combine field-based carcass monitoring with fine-scale demographic data from an intensively studied wild African elephant ...
Shah Ghafoor - - 2014
We present a method for smart auscultation by proposing a novel blind recovery of the original cardiac and respiratory sounds from a single observation mixture, in the framework of non-negative matrix factorization (NMF). The method learns the basis spectra of the mixing sources in unsupervised or semi-supervised fashion depending upon ...
Buck Louis Germaine M GM Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Rockville, Maryland, - - 2014
Background: The relation between persistent environmental chemicals and semen quality is evolving, though limited data exist for men recruited from general populations. Objectives: To assess the relation between perfluorinated chemicals (PFCs) and semen quality among 501 male partners of couples planning pregnancy. Methods: Utilizing population-based sampling strategies, we recruited 501 ...
Marostica Eleonora E Department of Industrial and Information Engineering, University of Pavia, Via Ferrata 1, 27100 , Pavia, Italy, - - 2014
Asthma is an obstructive lung disease where the mechanism of disease progression is not fully understood hence motivating the use of empirical models to describe the evolution of the patient's health state. With reference to placebo response, measured in terms of FEV1 (Forced Expiratory Volume in 1 s), a range of ...
Carey Mary-Katherine MK New England Center for Children and Western New England - - 2014
Continuous and discontinuous data-collection methods were compared in the context of discrete-trial programming. Archival data sets were analyzed using trial sampling (1st 5 trials, 1st 3 trials, and 1st trial only) and session sampling (every other session, every 3rd session, and every 5th session). Results showed that trial sampling systematically ...
Siegel Michael M Michael Siegel, Yamrot Negussie, Sarah Vanture, and Jane Pleskunas are with the Department of Community Health Sciences, Boston University School of Public Health, Boston, MA. Craig S. Ross is with Virtual Media Resources, Natick, MA. Charles King III is with Greylock McKinnon Associates, Cambridge, MA, and Pleiades Consulting Group, Lincoln, - - 2014
Objectives. We examined the relationship between gun ownership and stranger versus nonstranger homicide rates. Methods. Using data from the Supplemental Homicide Reports of the Federal Bureau of Investigation's Uniform Crime Reports for all 50 states for 1981 to 2010, we modeled stranger and nonstranger homicide rates as a function of ...
Novelli A A Atmospheric Chemistry Dept., Max Planck Institute for Chemistry, 55128 Mainz, Germany. - - 2014
The syn-CH3CHOO Criegee intermediate formed from the ozonolysis of propene and (E)-2-butene was detected via unimolecular decomposition and subsequent detection of OH radicals by a LIF-FAGE instrument. An observed time dependent OH concentration profile was analysed using a detailed model focusing on the speciated chemistry of Criegee intermediates based on ...
Braga-Neto Ulisses M UM Department of Electrical and Computer Engineering, Texas A&M University, College Station, TX, - - 2014
It is commonly assumed in pattern recognition that cross-validation error estimation is "almost unbiased" so long as the number of folds is not too small. While this is true for random sampling, it is not true with separate sampling, where the populations are independently sampled, a common situation in Bioinformatics. ...
Johnson Candice Y CY From the aRollins School of Public Health and Laney Graduate School, Emory University, Atlanta, GA; and bNational Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, - - 2014
Results of bias analyses for exposure misclassification are dependent on assumptions made during analysis. We describe how adjustment for misclassification is affected by incorrect assumptions about whether sensitivity and specificity are the same (nondifferential) or different (differential) for cases and noncases. We adjusted for exposure misclassification using probabilistic bias analysis, ...
McNeish Daniel M - - 2014
Recent studies have investigated the small sample properties of models for clustered data, such as multilevel models and generalized estimating equations. These studies have focused on parameter bias when the number of clusters is small, but very few studies have addressed the methods' properties with sparse data: a small number ...
Sreeramareddy Chandrashekhar T - - 2014
To estimate the amount of regret and weights of harm by omission and commission during therapeutic decisions for smear-negative pulmonary Tuberculosis. An interviewer-administered survey was done among young physicians in India, Pakistan and Bangladesh with a previously used questionnaire. The physicians were asked to estimate probabilities of morbidity and mortality ...
Haverkort Elizabeth B EB Department of Dietetics, Academic Medical Center, Amsterdam, the Netherlands - - 2014
Background: Bioelectrical impedance analysis (BIA) is a method used to estimate body compartments such as fat-free mass (FFM) and fat mass (FM). Two BIA devices, a single-frequency BIA (SF-BIA) device and a bioimpedance spectroscopy (BIS) approach, were compared to evaluate their reliability and to study whether their estimations resulted in ...
Colombo Valeria C VC Laboratorio de Ecología de Enfermedades (LEcEn), ICIVET LITORAL (UNL-CONICET), R.P. Kreder 2805, CP 3080, Esperanza, Santa Fe, Argentina. Electronic address: - - 2014
In this study we analyzed seasonal trends of immature stages of Ixodes loricatus parasitizing Akodon azarae (Sigmodontinae) in a locality of the Paraná Delta, Buenos Aires, Argentina. The data encompassed two consecutive years and the analysis included the control of potential confounders using Generalized Linear Mixed Models (GLMM) with a ...
Thomas Daniel B DB Department of Vertebrate Zoology, MRC-116, Smithsonian Institution, Washington, DC 20013-7012, USA Museum Conservation Institute, Smithsonian Institution, Suitland, MD 20746, USA Institute of Natural and Mathematical Sciences, Massey University, Auckland 0632, New Zealand - - 2014
The broad palette of feather colours displayed by birds serves diverse biological functions, including communication and camouflage. Fossil feathers provide evidence that some avian colours, like black and brown melanins, have existed for at least 160 million years (Myr), but no traces of bright carotenoid pigments in ancient feathers have ...
Yang Manshu M Health and Social Development Program, American Institute for Research, Chapel Hill, North Carolina, - - 2014
We analytically derive the fixed-effects estimates in unconditional linear growth curve models by typical linear mixed-effects modelling (TLME) and by a pattern-mixture (PM) approach with random-slope-dependent two-missing-pattern missing not at random (MNAR) longitudinal data. Results showed that when the missingness mechanism is random-slope-dependent MNAR, TLME estimates of both the mean ...
Lin Xiaoyan X Department of Statistics, University of South Carolina, Columbia, SC, 29208, USA, - - 2014
The proportional hazards (PH) model is the most widely used semiparametric regression model for analyzing right-censored survival data based on the partial likelihood method. However, the partial likelihood does not exist for interval-censored data due to the complexity of the data structure. In this paper, we focus on general interval-censored ...
Boers A M AM From the Departments of Radiology (A.M.B., I.A.Z., R.v.d.B., H.A.M., C.B.M.) and Biomedical Engineering and Physics (A.M.B., H.A.M.), Academic Medical Center, Amsterdam, the Netherlands; Institute of Technical Medicine (A.M.B.) and MIRA Institute for Biomedical Technology and Technical Medicine (C.H.S.), University of Twente, Enschede, the Netherlands; and Department of Neurology (C.S.G.), University Medical Centre Utrecht, Utrecht, the Netherlands. - - 2014
Quantification of blood after SAH on initial NCCT is an important radiologic measure to predict patient outcome and guide treatment decisions. In current scales, hemorrhage volume and density are not accounted for. The purpose of this study was to develop and validate a fully automatic method for SAH volume and ...
Sutter R R Clinic of Intensive Care Medicine, University Hospital Basel, Basel, Switzerland; Division of Clinical Neurophysiology, Department of Neurology, University Hospital Basel, Basel, Switzerland; Division of Neuroscience Critical Care, Department of Anesthesiology, Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Neurology, Johns Hopkins Bayview Medical Center, Baltimore, MD, - - 2014
Status epilepticus (SE) refractory to first- and second-line antiepileptic drugs carries high mortality. Little is known on early prediction of refractory SE (RSE) - an essential tool for planning appropriate therapy. Our aim was to identify and validate independent early RSE predictors in adults. Clinical and laboratory data on consecutive ...
Royston Patrick - - 2014
Most randomized controlled trials with a time-to-event outcome are designed and analysed under theproportional hazards assumption, with a target hazard ratio for the treatment effect in mind. However,the hazards may be non-proportional. We address how to design a trial under such conditions, andhow to analyse the results. We propose to ...
Zhen Chen C Capital Institute of Pediatrics, Beijing, People's Republic of China Peking University, Beijing, People's Republic of - - 2014
Background. Accurate determination and detection of fever is essential in the appropriate treatment of pediatric population. It is widely known that improper definitions of fever can cause grave and dangerous consequences in medical procedures. Infrared tympanic thermometry seems a relatively new and popular alternative for traditional measurement in the diagnosis ...
Lewis Kevin M KM Baxter Healthcare Corporation, One Baxter Parkway, Deerfield, IL 60015, USA. Electronic address: - - 2014
Purpose: Currently available hemostatic pads are effective in treating oozing bleeds, but otherwise ineffective in more severe bleeding. This study investigates the hemostatic efficacy of a new hemostatic pad with advanced sealing properties using protein-reactive polyethylene glycol-coated collagen (PCC, Hemopatch) versus an oxidized regenerated cellulose (ORC, Tabotamp/Surgicel Original) in a ...
McDonald Catherine C CC University of Pennsylvania, School of Nursing, Center for Global Women's Health, Center for Health Equity Research, Claire Fagin Hall, 418 Curie Boulevard, Philadelphia, PA 19104-4217, USA; Center for Injury Research and Prevention, The Children's Hospital of Philadelphia, 3535 Market Street, Suite 1150, Philadelphia, PA 19104, USA. Electronic address: - - 2014
Motor vehicle crashes are the leading cause of death and acquired disability during the first four decades of life. While teen drivers have the highest crash risk, few studies examine the similarities and differences in teen and adult driver crashes. We aimed to: (1) identify and compare the most frequent ...
Steffen Annika A Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke - - 2014
Background: Quantifying the risk of colorectal cancer (CRC) for individuals is likely to be useful for health service provision. Our aim was to develop and externally validate a prediction model to predict 5-year CRC risk. Methods: We used proportional hazards regression to develop the model based on established personal and ...
Yock Adam D AD Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030 and The Graduate School of Biomedical Sciences, The University of Texas Health Science Center at Houston, Houston, Texas - - 2014
To create models that forecast longitudinal trends in changing tumor morphology and to evaluate and compare their predictive potential throughout the course of radiation therapy. Two morphology feature vectors were used to describe 35 gross tumor volumes (GTVs) throughout the course of intensity-modulated radiation therapy for oropharyngeal tumors. The feature ...
Chandrakanth H V HV Department of Forensic Medicine, JSS Medical College, Mysore (a Constituent College of JSS University, Mysore), - - 2014
Estimation of sex is considered as one of the essential parameters in forensic anthropology and requires foremost attention in the analysis of commingled and unidentified remains. In India, there is a paucity of population specific morphometric standards for identifying sex from unknown human remains in different population groups. The present ...
Carabin Hélène H Department of Biostatistics and Epidemiology, College of Public Health, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States of - - 2014
Cystic echinococcosis (CE) is endemic in Spain but has been considered non-endemic in the province of Álava, Northern Spain, since 1997. However, Álava is surrounded by autonomous regions with some of the highest CE prevalence proportions in the nation, casting doubts about the current classification. The purpose of this study ...
Yoo Seungyeul S Icahn Institute of Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, United States of - - 2014
Errors in sample annotation or labeling often occur in large-scale genetic or genomic studies and are difficult to avoid completely during data generation and management. For integrative genomic studies, it is critical to identify and correct these errors. Different types of genetic and genomic data are inter-connected by cis-regulations. On ...
Haseltine Eric L EL Vertex Pharmaceuticals Incorporated, Boston, Massachussets, United States of - - 2014
For patients infected with hepatitis C virus (HCV), the combination of the direct-acting antiviral agent telaprevir, pegylated-interferon alfa (Peg-IFN), and ribavirin (RBV) significantly increases the chances of sustained virologic response (SVR) over treatment with Peg-IFN and RBV alone. If patients do not achieve SVR with telaprevir-based treatment, their viral population ...
Che W W WW Atmospheric Environmental Science, School of Science, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, - - 2014
Population and diary sampling methods are employed in exposure models to sample simulated individuals and their daily activity on each simulation day. Different sampling methods may lead to variations in estimated human exposure. In this study, two population sampling methods (stratified-random and random-random) and three diary sampling methods (random resampling, ...
Ibinda Fredrick F KEMRI/Wellcome Trust Research Programme, Centre for Geographic Medicine Research - Coast, Kilifi, - - 2014
The burden of epilepsy, in terms of both morbidity and mortality, is likely to vary depending on the etiology (primary [genetic/unknown] vs. secondary [structural/metabolic]) and with the use of antiepileptic drugs (AEDs). We estimated the disability-adjusted life years (DALYs) and modeled the remission rates of active convulsive epilepsy (ACE) using ...
Chen Qingxia Q Department of Biostatistics, Vanderbilt University, Nashville, TN, 37232, USA, - - 2014
The hazard ratio derived from the Cox model is a commonly used summary statistic to quantify a treatment effect with a time-to-event outcome. The proportional hazards assumption of the Cox model, however, is frequently violated in practice and many alternative models have been proposed in the statistical literature. Unfortunately, the ...
Napolitano Mariarosaria M 1 Department of Haematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità , Rome, Italy - - 2014
The Italian Hub of Population Biobanks (HIBP) includes both ongoing and completed studies that are heterogeneous in both their purpose and in the specimens collected. The heterogeneity in starting conditions makes sharing study data very difficult because of technical, ethical, and collection rights issues that hamper collaboration and synergy. With ...
Walter Carolin C Institute of Medical Informatics, University of Münster, Münster - - 2014
Basic4Cseq is an R/Bioconductor package for basic filtering, analysis and subsequent near-cis visualization of 4C-seq data. The package processes aligned 4C-seq raw data stored in binary alignment / map (BAM) format (Li et al., 2009) and maps the short reads to a corresponding virtual fragment library. Functions are included to ...
Wang Zhen Z Knowledge & Evaluation Research Unit, Mayo Clinic, 200 First Street SW, Rochester, MN 55904, USA. Electronic address: - - 2014
Systematic reviews (SRs) are the cornerstone of evidence-based medicine. In this study, we evaluated the effectiveness of using two computer screens on the efficiency of conducting SRs. A cohort of reviewers before and after using dual monitors were compared with a control group that did not use dual monitors. The ...
Sagara Issaka - - 2014
Recurrent events data analysis is common in biomedicine. Literature review indicates that most statistical models used for such data are often based on time to the first event or consider events within a subject as independent. Even when taking into account the non-independence of recurrent events within subjects, data analyses ...
Ryen Linda L Department of Economics, Karlstad University, Karlstad, - - 2014
There has been a rapid increase in the use of cost-effectiveness analysis, with quality adjusted life years (QALYs) as an outcome measure, in evaluating both medical technologies and public health interventions. Alongside, there is a growing literature on the monetary value of a QALY based on estimates of the willingness ...
1 2 3 4 5 6 7 8 9 10 >