Search Results
Results 1 - 50 of 2228
1 2 3 4 5 6 7 8 9 10 >
Mihaleva Velitchka V VV Laboratory of Biochemistry, Wageningen University, Dreijenlaan 3, 6703 HA, Wageningen, The Netherlands, - - 2014
An automated quantum mechanical total line shape (QMTLS) fitting model was implemented for quantitative nuclear magnetic resonance (NMR)-based profiling of 42 metabolites in ultrafiltrated human serum samples. Each metabolite was described by a set of chemical shifts, J-couplings, and line widths. These parameters were optimized for each metabolite in each ...
Unice Kenneth M KM Cardno ChemRisk, Pittsburgh, PA 15222. Electronic address: - - 2014
An updated biokinetic model for human exposures to cobalt (Co) was developed based on a comprehensive set of human pharmacokinetics data collected from five male and five female volunteers who ingested ∼1.0 mg Co/day of a Co supplement for three months. Three key experimental observations from the human dosing studies ...
Mattman Andre A Department of Pathology and Laboratory Medicine, St. Paul's Hospital, University of British Columbia, Vancouver, Canada. Electronic address: - - 2014
IgG4 related disease (IgG4RD) is detected in part by measurement of serum IgG4 levels in patients suspected to have the condition. The immunonephelometric methods that are used to measure serum IgG4 are susceptible to hook effect errors. The quality control parameter IgGRDiff=100* [Sum (IgG1, IgG2, IgG3, IgG4) - Total IgG] ...
Perola Emanuele E Vertex Pharmaceuticals Incorporated, 50 Northern Avenue, Boston, MA 02210, United States. Electronic address: - - 2014
A series of dual targeting inhibitors of bacterial gyrase B and topoisomerase IV were identified and optimized to mid-to-low nanomolar potency against a variety of bacteria. However, in spite of seemingly adequate exposure achieved upon IV administration, the in vivo efficacy of the early lead compounds was limited by high ...
Kohashi Michitaka M Division of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chu-o-ku, Kobe, Hyogo 650-0017, - - 2014
To improve the clinical course of ulcerative colitis (UC), more accurate serum diagnostic and assessment methods are required. We used serum metabolomics to develop diagnostic and assessment methods for UC. Sera from UC patients, Crohn's disease (CD) patients, and healthy volunteers (HV) were collected at multiple institutions. The UC and ...
Diaz-Ledezma Claudio C The Rothman Institute at Thomas Jefferson University, Philadelphia, PA, - - 2014
In the setting of finite healthcare resources, developing cost-efficient strategies for periprosthetic joint infection (PJI) diagnosis is paramount. The current levels of knowledge allow for PJI diagnostic recommendations based on scientific evidence but do not consider the benefits, opportunities, costs, and risks of the different diagnostic alternatives. We determined the ...
Ross H A HA Department of Laboratory Medicine, Laboratory of Genetic, Endocrine and Metabolic diseases, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands. Electronic address: - - 2014
Growth hormone (hGH) is a measurand belonging to ISO category 4, indicating intrinsic unavailability of a reference measurement procedure and primary standard material. Large between-method differences have been raising confusion, especially in the interpretation of results of stimulation tests for exclusion of juvenile growth hormone deficiency. Within the framework of ...
Ten Brink Marloes H MH *Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center; †LAP&P Consultants; and ‡Department of Pediatrics, Leiden University Medical Center, Leiden, The - - 2014
High-dose treosulfan is used in conditioning regimens before hematopoietic stem cell transplantation in children. Pharmacokinetic data to optimize treosulfan dosing are scarce in this patient population. The aims of this study were the development and validation of an analytical method for treosulfan in human serum and the development of a ...
Martus Peter P Institute of Clinical Epidemiology and Medical Biostatistics, UKT Tübingen, Eberhard Karls University - - 2014
Assessment of glomerular filtration rate (GFR) is crucial as the GFR value defines the stage of chronic kidney disease (CKD) and determines the adjustment of drug dosing. The aim was to investigate a new way for the accurate determination of glomerular filtration rate (GFR) in older adults based on the ...
Levey Andrew S AS William B. Schwartz Division of Nephrology, Tufts Medical Center, Department of Medicine, Tufts University School of Medicine, Boston, MA. Electronic address: - - 2014
Estimating glomerular filtration rate (GFR) is essential for clinical practice, research, and public health. Appropriate interpretation of estimated GFR (eGFR) requires understanding the principles of physiology, laboratory medicine, epidemiology, and biostatistics used in the development and validation of GFR estimating equations. Equations developed in diverse populations are less biased at ...
Le Jennifer J *Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla; †Miller Children's Hospital, Long Beach; and ‡Rady Children's Hospital, San Diego, - - 2014
Optimal monitoring of vancomycin in children needs evaluation using the exposure target with area under the curve (AUC) of the serum concentrations versus time over 24 hours. Our study objectives were to: (1) compare the accuracy and precision of vancomycin AUC estimations using 2 sampling strategies-1 serum concentration sample (1S, ...
Conroy Andrea L - - 2014
Dengue fever and leptospirosis have partially overlapping geographic distributions, similar clinical presentations and potentially life-threatening complications but require different treatments. Distinguishing between these cosmopolitan emerging pathogens represents a diagnostic dilemma of global importance. We hypothesized that perturbations in host biomarkers can differentiate between individuals with dengue fever and leptospirosis during ...
Feng Yan Y Bristol-Myers Squibb Company, Princeton, NJ, - - 2014
Ipilimumab is a fully human, monoclonal antibody that blocks cytotoxic T-lymphocyte antigen-4. The objective of the present study was to characterize the clinical pharmacology profile of ipilimumab using a population pharmacokinetic (PPK) approach. The PPK model was developed using 2095 ipilimumab serum concentration values from 499 patients with unresectable stage ...
Roberts Thomas C TC Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom ; Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California, United States of - - 2014
Extracellular microRNAs (miRNAs) are under investigation as minimally-invasive biomarkers for a wide range of disease conditions. We have recently shown in a mouse model of the progressive muscle-wasting condition Duchenne muscular dystrophy (DMD) that a set of highly elevated serum miRNAs reflects the regenerative status of muscle. These miRNAs are ...
Howell B A BA The Hamner-UNC Institute for Drug Safety Sciences, The Hamner Institutes, Research Triangle Park, North Carolina, - - 2014
Entolimod (CBLB502) is a Toll-like receptor 5 agonist in development as a single-dose countermeasure against total body irradiation. Efficacy can be assessed from animal studies, but the "Animal Rule" does not apply to safety assessment. Marked elevations of serum aminotransferases (exceeding 1,000 IU/l) were observed in some human subjects receiving ...
- - 2014
[This corrects the article DOI: 10.1371/journal.pone.0086749.].
Trujillo-de Santiago Grissel G FEMSA-Biotechnology Center, Monterrey Tech (Centro de Biotecnología-FEMSA, Tecnológico de Monterrey). Ave. Eugenio Garza Sada 2501 sur. Col. Tecnológico, Monterrey, Nuevo León, - - 2014
Contraceptive patches have become a frequently used contraceptive method. We present a mathematical model that describes the serum concentration profiles of Norelgestromin (NGMN) and Ethinylestradiol (EE) released from the contraceptive patch Ortho Evra(®). We propose a simple one-compartment model based on pharmacokinetics data reported in previous studies. The model assumes ...
Song Jue J School of Pharmacy, Anhui Medical University, Meishan Road 81, Hefei, 230032, Anhui, - - 2013
Yu-ping-feng decoction (YPF), a traditional Chinese medicine (TCM) prescription, is widely used to treat some respiratory tract diseases. This study was aimed to set up a pharmacokinetic-pharmacodynamic (PK-PD) model to assess dose-effect relationships for immunomodulatory effects of YPF in rats and to clarify compatibility mechanisms for TCM prescription system. Serum ...
Zhang Xiaohui X College of Environment and Chemical Engineering, Dalian University, Dalian, Liaoning 116622, China. Electronic address: - - 2013
The interaction between 4-thio-5-methyluridine and human serum albumin (HSA) under simulative physiological conditions has been studied by the methods of fluorescence, UV-VIS absorbance and circular dichroism (CD) spectroscopy. The results show that 4-thio-5-methyluridine has a static fluorescence quenching on human serum albumin (HSA). The main forces of both interactions have ...
Bokkhim Huma H The University of Queensland, School of Agriculture and Food Sciences, Brisbane, QLD 4072, Australia. Electronic address: - - 2014
Lactoferrin (Lf) samples with ca. 25%, 50%, 75%, 85% and 100% iron saturation were prepared for the purpose of evaluating Chromametry, Differential Scanning Calorimetry (DSC) and Circular Dichroism (CD) spectropolarimetry for their suitability in determining the iron saturation level. Numerical values for colour from Chromametry, enthalpy change of denaturation (ΔHcal) ...
Gholivand Mohammad-Bagher MB Faculty of Chemistry, Razi University, Kermanshah 671496734, Iran. Electronic address: - - 2014
For the first time, several multivariate calibration (MVC) models including partial least squares-1 (PLS-1), continuum power regression (CPR), multiple linear regression-successive projections algorithm (MLR-SPA), robust continuum regression (RCR), partial robust M-regression (PRM), polynomial-PLS (PLY-PLS), spline-PLS (SPL-PLS), radial basis function-PLS (RBF-PLS), least squares-support vector machines (LS-SVM), wavelet transform-artificial neural network (WT-ANN), ...
Oda Kazutaka - - 2013
The serum level of teicoplanin (TEIC) is immediately elevated following administration of the recommended dose. In this study, the predictability of the serum trough for TEIC was investigated at day 2 or 3 (C2-3), and the authors performed a simulation based on the Bayesian method using C2-3 in Japanese patients. ...
Mayo P R - - 2013
The aims of this population-pharmacokinetic/pharmacodynamic (POP-PKPD) analysis of voclosporin in renal allograft patients were to build a POP-PKPD model for voclosporin and calcineurin activity (CNa) and identify clinically relevant covariates that could assist dosing of the drug. POP-PKPD modeling was performed using a stochastic approximation of the standard expectation maximization ...
Bansal Navneeta - - 2013
To address the shortcomings of urine cytology and cystoscopy for probing and grading of urinary bladder cancer (BC), we applied 1H-nuclear magnetic resonance (NMR) spectroscopy as a surrogate method for identification of BC. This study includes 99 serum samples; comprising low-grade (LG, n=36) and high-grade (HG, n=31) of BC, and ...
Park Hyunjin - - 2013
In the existing compartmental models of human vitamin A metabolism, parameters related to the absorption of the isotopic oral dose have not been well identified. We hypothesised that fixing some poorly identified parameters related to vitamin A absorption would improve parameter identifiability and add statistical certainty to such models. In ...
Chehade Hassib - - 2013
The estimated GFR (eGFR) is important in clinical practice. To find the best formula for eGFR, this study assessed the best model of correlation between sinistrin clearance (iGFR) and the solely or combined cystatin C (CysC)- and serum creatinine (SCreat)-derived models. It also evaluated the accuracy of the combined Schwartz ...
Mitchell Simon - - 2013
Iron is essential for all known life due to its redox properties; however, these same properties can also lead to its toxicity in overload through the production of reactive oxygen species. Robust systemic and cellular control are required to maintain safe levels of iron, and the liver seems to be ...
Casale Teodorico - - 2013
To evaluate whether the exposure to arsenic (As) causes alterations of liver enzymes in two groups of outdoor workers. Total urinary As and the levels of AST/GOT, ALT/GPT, and GGT were measured on 80 traffic policemen and 50 police drivers. Personal air samples were obtained for assessing the exposure to ...
Carobene Anna - - 2013
Creatinine determination in serum is a key indicator of kidney glomerular function. A reference measurement system for its standardization is available and virtually all IVD manufacturers have aligned their assays to this system. In this study, we verified the impact of these standardization efforts on the results of an Italian ...
Murray-Kolb Laura E - - 2013
The purpose of this study is to highlight recent research findings that advance our understanding of the relation between iron status and neural functioning. Recent findings have helped to answer questions pertaining to the interrelationship of iron and neural functioning in three primary areas: reversibility of changes occurring with early-life ...
Langers Pieter - - 2013
The immunosuppressive drug mycophenolate mofetil (MMF), with mycophenolic acid (MPA) as active metabolite, is a nonnephrotoxic alternative to calcineurin inhibitors. Therapeutic drug monitoring (TDM) of MPA may improve clinical benefit from MMF therapy, especially in MMF monotherapy or with reduced dose of a calcineurin inhibitor. Limited data are available on ...
Hasegawa Chihiro - - 2013
ONO-5334, a selective inhibitor of cathepsin K, is a potential new treatment for osteoporosis. The objectives of this study were to (1) develop population pharmacokinetic-pharmacodynamic (PK-PD) models for ONO-5334 using dose-ascending data from healthy postmenopausal females, (2) examine comparability of PK and/or PD profile between Caucasian and Japanese, and (3) ...
Polyzos Stergios A - - 2013
Abstract Objective: The potential development of a noninvasive marker predicting nonalcoholic steatohepatitis (NASH). Methods: Thirty patients with biopsy-proven nonalcoholic fatty liver disease were evaluated by numerous anthropometric, clinical and biochemical parameters. Results: Serum glutamic oxaloacetic transaminase (SGOT; p = 0.027), log (erythrocyte sedimentation rate) (ESR; p = 0.034) and homocysteine (p = 0.041) were associated with ...
Driscoll R O - - 2013
Immunogenicity assessment of fully human monoclonal antibody-based biotherapeutics requires sensitive and specific ligand binding assays. One of the components of specificity is the depletion of signal by a relevant biotherapeutic that is commonly based on an arbitrary depletion criterion of inhibition of the original response or reduction of the signal ...
Finn Nnenna A NA Division of Cardiology, Emory University School of Medicine, Atlanta, GA 30322, United - - 2013
The discovery of extracellular microRNAs (miRNAs) and their transport modalities (i.e., microparticles, exosomes, proteins and lipoproteins) has sparked theories regarding their role in intercellular communication. Here, we assessed the information transfer capacity of different miRNA transport modalities in human serum by utilizing basic principles of information theory. Zipf Statistics were ...
Lafeber Floris Pjg - - 2013
In 2010, in Osteoarthritis and Cartilage, we published a comprehensive systematic review applying the consensus BIPED criteria on serum and urinary biochemical markers for knee and hip osteoarthritis (OA) using publications that were available at that time. It appeared that none of the biochemical markers at that time were sufficiently ...
Gomeni R - - 2013
RBP-7000 is a sustained-release (once-monthly injection for subcutaneous administration) formulation of risperidone using the ATRIGEL® Delivery System, developed for treatment of schizophrenia to address compliance issues associated with oral administration. The objective of this analysis was to report the results of a population pharmacokinetic analysis and to describe the relationship ...
Asnani Monika R - - 2013
Various estimating equations have been developed to estimate glomerular filtration rate (GFR) for use in clinical practice. However, the unique renal physiological and pathological processes that occur in sickle cell disease (SCD) may invalidate these estimates in this patient population. This study aims to compare GFR estimated using common existing ...
Proetzel Gabriele - - 2013
A key element for the successful development of novel therapeutic antibodies is to fully understand their pharmacokinetic and pharmacodynamic behavior before performing clinical trials. While many in vitro modeling approaches exist, these simply cannot substitute for data obtained from appropriate animal models. It was established quite early that the unusual ...
Sharma Neel Kamal - - 2013
The primary goal of tailored medicine is to presymptomatically identify individuals at high risk for disease using information of each individual's genetic profile and collection of environmental risk factors. Recently, algorithms were given the strong recognition of several replicated risk factors for age-related macular degeneration (AMD), this distant goal is ...
Korfali Samira I - - 2013
Toxic metals and phthalates are introduced in the manufacturing of plastic toys and modeling clays. In Lebanon, inexpensive plastic toys and modeling clays (sold in dollar stores) are affordable and popular, and there is no legislation to monitor or regulate such toys. This study aimed to assess the quality of ...
Murayama I - - 2013
The isotonic, nonionic, contrast medium iodixanol, as a test substance, was compared with the conventional glomerular filtration rate (GFR) tracer inulin to establish a simplified procedure for estimating the GFR in Holstein dairy cows. First, inulin and iodixanol were coadministered as a bolus intravenous injection to clinically healthy cows at ...
Carobene Anna - - 2013
commutability is an essential requirement for control materials used in external quality assessment schemes. Testing control materials for commutability requires costly and time-consuming experiments. The aim of our work was the validation of a more effective way to evaluate commutability. commutability of two control materials for gamma-glutamyltransferase (GGT) activity between ...
Tolan Nicole V - - 2013
BACKGROUND: Accuracy of serum neuron-specific enolase (NSE) measurement is paramount, particularly in the context of neurological outcome prognostication. However, NSE measurements are compromised by even slight hemolysis, as it is abundant in red blood cells (RBCs). We derived and validated an individualized hemolysis correction equation in an attempt to reduce ...
Du Shunda - - 2013
BACKGROUND: A new kinetic model of technetium-99m-labeled diethylenetriaminepentaacetic acid-galactosyl human serum albumin (Tc-GSA) was developed to show the speed of asialoglycoprotein receptor-mediated endocytosis. MATERIALS AND METHODS: Ten healthy volunteers and 17 patients with liver cirrhosis were intravenously injected with 185 MBq of Tc-GSA, and dynamic planar images were acquired. The ...
Kim Sung Eun - - 2013
: The aim of this study was to investigate the population pharmacokinetics of theophylline in premature Korean infants and to assess the influence of clinical covariates. : Blood samples were first obtained after 1 week of maintenance dosing and then acquired approximately 4 weeks after continuous dosing. The time points ...
Andriansyah - - 2013
There is a paucity of basic biological information for the Sumatran rhinoceros (Dicerorhinus sumatrensis). This information is fundamental to husbandry and management practices for captive animals and for support of in situ conservation efforts. Serial blood samples were collected over an 8-yr period to evaluate patterns in hematology and serum ...
Rule Andrew D - - 2013
The application of serum creatinine and cystatin C in patients with CKD has been limited to using estimated glomerular filtration rate (eGFR). Criteria for choosing the best GFR estimating equation are 1) accuracy in estimating measured GFR, 2) optimal discrimination of clinical outcomes, and 3) association with CKD risk factors ...
Nishimura Yuhei - - 2013
Disruption of the blood-brain barrier (BBB) can occur in various pathophysiological conditions. Administration of extraneous tracers that can pass the disrupted, but not the intact, BBB and detection of the extravasation have been widely used to assess BBB disruption in animal models. Although several fluorescent tracers have been successfully used, ...
Wu Baojian - - 2013
Glucuronidation has been recognized as an important clearance mechanism in humans. Therefore, knowledge about the contribution of glucuronidation to clearance of drug candidates is of great value for early drug development. In this article, we discuss the recent progress made to predict in vivo glucuronidation parameters (e.g., hepatic clearance, and ...
1 2 3 4 5 6 7 8 9 10 >