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Ruf Irina I Steinmann-Institut für Geologie, Mineralogie und Paläontologie, Rheinische Friedrich-Wilhelms-Universität Bonn, Nussallee 8, 53115, Bonn, Germany; Senckenberg Forschungsinstitut und Naturmuseum Frankfurt, Abteilung Palāoanthropologie und Messelforschung, Sektion Mammalogie, Senckenberganlage 25, 60325, Frankfurt am Main, - - 2014
In order to elucidate the systematic relevance of the turbinal skeleton in Lagomorpha the ethmoidal regions of 6 ochotonid, 21 leporid, and 2 outgroup species (Sciurus vulgaris, Tupaia sp.) species were investigated by high-resolution computed tomography (μCT). Number and shape of turbinals correspond to major clades and to several genera. ...
Tsang Althea S-K AS Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, 52056 Aachen - - 2014
This article showcases three major uses of computational chemistry in reactivity studies: the application after, in combination with, and before experiment. Following a brief introduction of suitable computational tools, challenges and opportunities in the implementation of computational chemistry in reactivity studies are discussed, exemplified with selected case studies from our ...
Maki Bloomquist A K AK Sunnybrook Research Institute, 2075 Bayview Avenue, Toronto, Ontario M4N 3M5, - - 2014
A reader study was conducted to tune the parameters of an observer model used to predict the detectability index (d' ) of test objects as a task-based quality control (QC) metric for digital mammography. A simple test phantom was imaged to measure the model parameters, namely, noise power spectrum, modulation transfer ...
Moses W W WW Lawrence Berkeley National Laboratory, Berkeley, CA 94720, - - 2014
Digital methods are becoming increasingly popular for measuring time differences, and are the de facto standard in PET cameras. These methods usually include a master system clock and a (digital) arrival time estimate for each detector that is obtained by comparing the detector output signal to some reference portion of ...
Brynolfsson Patrik P Department of Radiation Physics, Umeå University, Umeå, - - 2014
The purpose of this study was to investigate, using simulations, a method for improved contrast agent (CA) quantification in DCE-MRI. We developed a maximum likelihood estimator that combines the phase signal in the DCE-MRI image series with an additional CA estimate, e.g. the estimate obtained from magnitude data. A number ...
Jagtap Pratik Dilip - - 2014
Proteogenomics combines large-scale genomic and transcriptomic data with mass spectrometry-based proteomic data to discover novel protein sequence variants and improve genome annotation. In contrast to conventional proteomic applications, proteogenomic analysis requires a number of additional data processing steps. Ideally, these required steps would be integrated and automated via a single ...
Si Dong D Department of Computer Science, Old Dominion University, Norfolk, VA 23529, - - 2014
Major secondary structure elements such as α helices and β sheets can be computationally detected from cryoelectron microscopy (cryo-EM) density maps with medium resolutions of 5-10 Å. However, a critical piece of information for modeling atomic structures is missing, because there are no tools to detect β strands from cryo-EM maps ...
Rohr Rudolf P RP Integrative Ecology Group, Estación Biológica de Doñana, Consejo Superior de Investigaciones Científicas, Calle Américo Vespucio s/n, E-41092 Sevilla, - - 2014
Abstract Recent studies have shown a phylogenetic signal in the structure of ecological networks, making the point that evolutionary history is important in explaining network architecture. However, this previous work has focused on either antagonistic (i.e., predator-prey) or mutualistic networks and has used different methodologies. Thus, a comparative assessment of ...
Falcy Matthew R MR Oregon Department of Fish and Wildlife, 4034 Fairview Industrial Dr SE., Salem, OR, USA, - - 2014
1.An extensive body of theory suggests that density-dependent habitat selection drives many fundamental ecological processes. The ideal free distribution and the ideal despotic distribution make contrasting predictions about the effect of total population size on relative abundances among habitats. Empirical assessment of these habitat selection models is uncommon because data ...
Kunz Michael M Goethe University Frankfurt, Buchmann Institute for Molecular Life Sciences and Institute for Biophysics, Max-von-Laue Str. 15, 60438 Frankfurt am Main, - - 2014
In tomography, the quality of the reconstruction is essential because the complete cascade of the subsequent analysis is based on it. To date, weighted back-projection (WBP) has been the most commonly used technique due to its versatility and performance in sub-tomogram averaging. Here we present super-sampling SART that is based ...
Elliot Michael G MG Human Evolutionary Studies Program, Simon Fraser University, British Columbia, Canada V5A 1S6. Electronic address: - - 2014
Inferences about the evolution of continuous traits based on reconstruction of ancestral states have often been considered more error-prone than analysis of independent contrasts. Here we show that both methods in fact yield identical estimators for the correlation coefficient and regression gradient of correlated traits, indicating that reconstructed ancestral states ...
Chu Dominique D School of Computing, University of Kent, CT2 7NF, Canterbury, UK. Electronic address: - - 2014
Amorphous computing is a non-standard computing paradigm that relies on massively parallel execution of computer code by a large number of small, spatially distributed, weakly-interacting processing units. Over the last decade or so, amorphous computing has attracted a great deal of interest both as an alternative model of computing and ...
Wang Hui H Palo Alto Veterans Institute for Research; - - 2014
We present a novel semiparametric method for quantitative trait loci (QTL) mapping in experimental crosses. Conventional genetic mapping methods typically assume parametric models with Gaussian errors and obtain parameter estimates through maximum likelihood estimation. In contrast with univariate regression and interval mapping methods, our model requires fewer assumptions and also ...
Cordue Paul P Biomathematics Research Centre, Department of Mathematics and Statistics, University of Canterbury, Christchurch, New Zealand, - - 2014
In the last decade, the use of phylogenetic networks to analyze the evolution of species whose past is likely to include reticulation events, such as horizontal gene transfer or hybridization, has gained popularity among evolutionary biologists. Nevertheless, the evolution of a particular gene can generally be described without reticulation events ...
Johnston Matthew W MW National Coral Reef Institute, Nova Southeastern University Oceanographic Center, 8000 North Ocean Drive, Dania Beach, FL 33004, United States. Electronic address: - - 2014
The Atlantic invasion of Indo-Pacific lionfish (Pterois volitans/P. miles) has been as swift as it has been disastrous. Lionfish are non-native to the Mediterranean, but an invasion is perhaps even more likely than for the Atlantic. First, as for the Atlantic, there are many major cities on the coast of ...
Piai Vitória V Department of Psychology and the Helen Wills Neuroscience Institute, University of California at Berkeley, Berkeley, California, USA; Radboud University Nijmegen, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, The - - 2014
When making statistical comparisons, the temporal dimension of the EEG signal introduces problems. Guthrie and Buchwald (1991) proposed a formally correct statistical approach that deals with these problems: comparing waveforms by counting the number of successive significant univariate tests and then contrasting this number to a well-chosen critical value. However, ...
Glöckner Andreas A Department of Psychology, University of Göttingen, Germany; Max Planck Institute for Research on Collective Goods, Bonn, Germany. Electronic address: - - 2014
There is broad consensus that human cognition is adaptive. However, the vital question of how exactly this adaptivity is achieved has remained largely open. Herein, we contrast two frameworks which account for adaptive decision making, namely broad and general single-mechanism accounts vs. multi-strategy accounts. We propose and fully specify a ...
Alves-Rausch José J Sartorius Stedim Biotech GmbH, August-Spindler-Str. 11, 37079 Goettingen, Germany. Electronic address: - - 2014
NIR spectroscopy was used to monitor Bacillus fermentations in 50m(3) reactors under harsh industrial conditions. The BioPAT(®) Spectro NIR sensor was attached directly to the bioreactor and provided fast, sensitive, non-destructive and robust measurements without interfering with the microorganism metabolism. Multivariate data analysis techniques related the spectra collected in real ...
Tsukada Hiromichi H Research Institute for Electronic Science, Hokkaido University, Sapporo 060-0812, Japan. Electronic address: - - 2014
Patients with dementia with Lewy bodies (DLB) frequently experience visual hallucination (VH), which has been aptly described as people seeing things that are not there. The distinctive character of VH in DLB necessitates a new theory of visual cognition. We have conducted a series of studies with the aim to ...
Ilari-Antoine E E 1The French Pork and Pig Institute (IFIP),Economy Unit,34 Boulevard de la Gare,F-31500 - - 2014
The aim of this paper is to present an efficient tool for evaluating the economy part of the sustainability of pig farming systems. The selected tool IDEA was tested on a sample of farms from 15 contrasted systems in Europe. A statistical analysis was carried out to check the capacity ...
Pattison Adam - - 2014
Dynamic mechanical analysis (DMA) is a common way to measure the mechanical properties of materials as functions of frequency. Traditionally, a viscoelastic mechanical model is applied and current DMA techniques fit an analytical approximation to measured dynamic motion data by neglecting inertial forces and adding empirical correction factors to account ...
Neumayer Bernhard B Ludwig Boltzmann Institute for Clinical Forensic Imaging, Universitätsplatz 4, A-8010, Graz, - - 2014
In clinical forensic medicine, the estimation of the age of injuries such as externally visible subcutaneous hematomas is important for the reconstruction of violent events, particularly to include or exclude potential suspects. Since the estimation of the time of origin based on external inspection is unreliable, the aim of this ...
Rolletschek Hardy H Leibniz-Institut für Pflanzengenetik und Kulturpflanzenforschung (IPK), Gatersleben, - - 2014
The large numbers of samples processed in breeding and biodiversity programmes require the development of efficient methods for the nondestructive evaluation of basic seed properties. Near-infrared spectroscopy is the state-of-the-art solution for this analytical demand, but it also has some limitations. Here, we present a novel, rapid, accurate procedure based ...
Liu Xuesong X School of Mathematical Science, Dalian University of Technology, Dalian 116024, - - 2014
An evolutionary dynamic model of 2×2 games with finite population of size N+M was built. Among these individuals, N individuals have the same update mechanism as that of Moran process, while the other M individuals have the same update mechanism as that of Fermi process. We obtain the balance equations ...
Gayetskyy Svitlana - - 2014
Angiogenesis is an important pathophysiological process of chronic inflammation, especially in inflammatory arthritis. Quantitative measurement of changes in vascularization may improve the diagnosis and monitoring of arthritis. The aim of this work is the development of a 3D imaging and analysis framework for quantification of vascularization in experimental arthritis. High-resolution ...
Kellman Peter P National Heart, Lung, and Blood Institute, National Institutes of Health, DHHS, 10 Center Drive MSC-1061, Bethesda 20892, MD, USA. - - 2014
T1-mapping has the potential to detect and quantify diffuse processes such as interstitial fibrosis. Detection of disease at an early stage by measurement of subtle changes requires a high degree of reproducibility. Initial implementation of saturation recovery (SR) T1-mapping employed 3-parameter fitting which was highly accurate but was quite sensitive ...
Mitra Amitava A Biopharmaceutics, Pharmaceutical Sciences and Clinical Supply, Merck & Co. Inc, West Point, Pennsylvania, 19486, USA, - - 2014
As part of the overall product development and manufacturing strategy, pharmaceutical companies routinely change formulation and manufacturing site. Depending on the type and level of change and the BCS class of the molecule, dissolution data and/or bioequivalence (BE) may be needed to support the change for immediate release dosage forms. ...
Dioury Fabienne - - 2014
Gadolinium(III) complexes constitute the largest class of compounds used as contrast agents for Magnetic Resonance Imaging (MRI). A quantitative structure-property relationship (QSPR) machine-learning based method is applied to predict the thermodynamic stability constants of these complexes (log KGdL), a property commonly associated with the toxicity of such organometallic pharmaceuticals. In ...
Sawa Koji K Senior High School, Japan Women's University, Tama, Kawasaki 214-8565, Japan. Electronic address: - - 2014
In this paper, we mainly address three issues: externality of an agent, purpose of an agent, and a kind of "softness" of components in a system. Agents are independent of a system in an ordinary multi-agent model, hence the behavior of a system is not autonomous but influenced by the ...
Gebauer Jochen E - - 2014
A sociocultural motives perspective (SMP) on Big Five relationships is introduced. According to the SMP, Agreeableness and Conscientiousness elicit assimilation to sociocultural norms, Openness elicits contrast from these norms, and Extraversion and Neuroticism are independent of sociocultural assimilation and contrast. Due to sociocultural assimilation, then, relationships of Agreeableness and Conscientiousness ...
Lu Yafeng - - 2014
With over 16 million tweets per hour, 600 new blog posts per minute, and 400 million active users on Facebook, businesses have begun searching for ways to turn real-time consumer-based posts into actionable intelligence. The goal is to extract information from this noisy, unstructured data and use it for trend ...
Jiang Dingfeng D Exploratory Statistics, Data and Statistical Science, AbbVie Inc. - - 2014
Recent studies have demonstrated theoretical attractiveness of a class of concave penalties in variable selection, including the smoothly clipped absolute deviation and minimax concave penalties. The computation of the concave penalized solutions in high-dimensional models, however, is a difficult task. We propose a majorization minimization by coordinate descent (MMCD) algorithm ...
Zhou Yuan - - 2014
Based on the vector form Snell's law, ray tracing is performed to quantify the pointing errors of Risley-prism-based beam steering systems, induced by component errors, prism orientation errors, and assembly errors. Case examples are given to elucidate the pointing error distributions in the field of regard and evaluate the allowances ...
Zhao Bo B Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA; Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, Illinois, - - 2014
To enable accurate magnetic resonance (MR) parameter mapping with accelerated data acquisition, utilizing recent advances in constrained imaging with sparse sampling. A new constrained reconstruction method based on low-rank and sparsity constraints is proposed to accelerate MR parameter mapping. More specifically, the proposed method simultaneously imposes low-rank and joint sparse ...
Weidner Christopher C Otto Warburg Laboratory, Max Planck Institute for Molecular Genetics, Ihnestrasse 63-73, 14195 Berlin, - - 2014
Summary: We introduce PHOXTRACK (PHOsphosite-X-TRacing Analysis of Causal Kinases), a user-friendly, freely available software tool for analysing large data sets of post-translational modifications of proteins such as phosphoryla-tion, which are commonly gained by mass spectrometry detection. In contrast to other currently applied data analysis approaches, PHOXTRACK uses full sets of ...
da Silva Maciel Lucas - - 2014
A novel algorithm for phase unwrapping based on swarm intelligence is proposed. The algorithm was designed based on three main goals: maximum coverage of reliable information, focused effort for better efficiency, and reliable unwrapping. Experiments were performed, and a new agent was designed to follow a simple set of five ...
Estellon Johan J Univ. Grenoble Alpes, iRTSV-BGE, F-38000 Grenoble, France. - - 2014
Metalloproteins represent a ubiquitous group of molecules which are crucial to the survival of all living organisms. While several metal-binding motifs have been defined, it remains challenging to confidently identify metalloproteins from primary protein sequences using computational approaches alone. Here, we describe a comprehensive strategy based on a machine learning ...
Leow Melvin Khee-Shing - - 2014
Despite rendering serum free thyroxine (FT4) and thyrotropin (TSH) within the normal population ranges broadly defined as euthyroidism, many patients being treated for hyperthyroidism and hypothyroidism persistently experience subnormal well-being discordant from their pre-disease healthy euthyroid state. This suggests that intra-individual physiological optimal ranges are narrower than laboratory-quoted normal ranges ...
Zaidi Ali H AH Institute for the Treatment of Esophageal and Thoracic Disease, Allegheny Health Network, Pittsburgh, - - 2014
Esophageal adenocarcinoma (EAC) is associated with a dismal prognosis. The identification of cancer biomarkers can advance the possibility for early detection and better monitoring of tumor progression and/or response to therapy. The authors present results from the development of a serum-based, 4-protein (biglycan, myeloperoxidase, annexin-A6, and protein S100-A9) biomarker panel ...
Cataldo Salvatore S Dipartimento di Fisica e Chimica, Università degli Studi di Palermo, Viale delle Scienze, I-90128 Palermo, - - 2014
Systematic kinetic and equilibrium studies on the lead ions removal ability by Ca-alginate gel beads have been performed by varying several internal parameters, namely, number of gel beads, nature and composition of the ionic medium and pH, which allowed us to model a wastewater in order to closely reproduce the ...
Merrill Scott C - - 2014
The Russian wheat aphid, Diuraphis noxia (Kurdjumov) is a serious pest of small grains, such as wheat and barley. High population growth rates and a broad gramineae host range have allowed this aphid to successfully establish and become pestiferous across much of North America since its invasion in the mid-1980s. ...
Mader Malenka M Department of Neuropediatrics and Muscular Disease, University Medical Center of Freiburg, Freiburg, Germany and Freiburg Center for Data Analysis and Modeling (FDM), University of Freiburg, Freiburg, Germany and Institute for Physics, University of Freiburg, Freiburg, Germany and Center for Neural Engineering, Pennsylvania State University, State College, Pennsylvania 16801, USA and Department of Engineering Science and Mechanics, Pennsylvania State University, State College, Pennsylvania 16801, - - 2014
Reliable forecasts of extreme but rare events, such as earthquakes, financial crashes, and epileptic seizures, would render interventions and precautions possible. Therefore, forecasting methods have been developed which intend to raise an alarm if an extreme event is about to occur. In order to statistically validate the performance of a ...
O'Bryant Sid E SE Department of Internal Medicine, University of North Texas Health Science Center, Fort Worth, TX, USA Institute for Aging & Alzheimer's Disease Research, University of North Texas Health Science Center, Fort Worth, TX, - - 2014
Background: There is a significant need for rapid and cost-effective biomarkers of Alzheimer's disease (AD) for advancement of clinical practice and therapeutic trials. Objective: The aim of the current study was to cross-validate our previously published serum-based algorithm on an independent assay platform as well as validate across tissues and ...
Zhang Yi Y Genentech, Inc., South San Francisco, - - 2014
To describe the systemic pharmacokinetics of ranibizumab after intravitreal administration in patients with retinal vein occlusion (RVO) or diabetic macular edema (DME). A population approach of nonlinear mixed-effect pharmacokinetics modeling based on serum concentrations of ranibizumab measured at various times after intravitreal administration. Patients with RVO (n = 441) and ...
Potdar Alka A AA Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, United States of America; Department of Cellular and Molecular Medicine, Cleveland Clinic, Cleveland, Ohio, United States of - - 2014
A major process of iron homeostasis in whole-body iron metabolism is the release of iron from the macrophages of the reticuloendothelial system. Macrophages recognize and phagocytose senescent or damaged erythrocytes. Then, they process the heme iron, which is returned to the circulation for reutilization by red blood cell precursors during ...
Sun Yi Y Department of Electrical Engineering, The City College of City University of New York, New York, NY, - - 2014
In this paper, we propose and investigate distribution of intravascular and extravascular extracellular volume fractions (DIEEF) as a noninvasive biomarker for neovascularization assessment by dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). A generalized two-compartment exchange model (G2CXM) that uniformly includes the Patlak model, Tofts model, extended Tofts model, and recent two-compartment ...
Kuleshina O N ON G. N. Gabrichevsky Moscow Research Institute of Epidemiology and Microbiology, Federal Service on Surveillance for Consumer Rights Protection and Human Wellbeing, Moscow, - - 2014
A new universal method for measuring activity of the serum complement system in humans, laboratory, domestic, agricultural animals, birds and amphibians is based on automated evaluation of the mortality of ciliate Tetrahymena pyriformis under the effect of the complement system. In contrast to the hemolytic method, measured activity of the ...
Pinkert Denise D Institut für Chemie, Humboldt-Universität zu Berlin, Brook-Taylor Str. 2, 12489 Berlin (Germany), Fax: - - 2014
Iron centres incorporated in silicate frameworks or located in their pores have been shown to possess unique catalytic properties. As compared to aluminosilicates this area of zeolite chemistry is much younger and in the first part of this review the findings made so far are summarised. Molecular model compounds may ...
Yadav Anand Prakash AP Immunomodulation Laboratory, Defence Institute of Physiology & Allied Sciences, Lucknow Road, Timarpur, Delhi 110054, - - 2014
The Antarctic context is an analogue of space travel, with close similarity in ambience of extreme climate, isolation, constrained living spaces, disrupted sleep cycles, and environmental stress. The present study examined the impact of the harsh habitat of Antarctica on human physiology and its metabolic pathways, by analyzing human serum ...
Zhang Yin-Gang - - 2014
The identification of the cause of chronic low back pain (CLBP) represents a great challenge to orthopedists due to the controversy over the diagnosis of discogenic low back pain (DLBP) and the existence of a number of cases of CLBP of unknown origin. This study aimed to develop diagnostic models ...
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