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O'Bryant Sid E SE Department of Internal Medicine, University of North Texas Health Science Center, Fort Worth, TX, USA Institute for Aging & Alzheimer's Disease Research, University of North Texas Health Science Center, Fort Worth, TX, - - 2014
Background: There is a significant need for rapid and cost-effective biomarkers of Alzheimer's disease (AD) for advancement of clinical practice and therapeutic trials. Objective: The aim of the current study was to cross-validate our previously published serum-based algorithm on an independent assay platform as well as validate across tissues and ...
Zhang Yi Y Genentech, Inc., South San Francisco, - - 2014
To describe the systemic pharmacokinetics of ranibizumab after intravitreal administration in patients with retinal vein occlusion (RVO) or diabetic macular edema (DME). A population approach of nonlinear mixed-effect pharmacokinetics modeling based on serum concentrations of ranibizumab measured at various times after intravitreal administration. Patients with RVO (n = 441) and ...
Potdar Alka A AA Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, United States of America; Department of Cellular and Molecular Medicine, Cleveland Clinic, Cleveland, Ohio, United States of - - 2014
A major process of iron homeostasis in whole-body iron metabolism is the release of iron from the macrophages of the reticuloendothelial system. Macrophages recognize and phagocytose senescent or damaged erythrocytes. Then, they process the heme iron, which is returned to the circulation for reutilization by red blood cell precursors during ...
Kuleshina O N ON G. N. Gabrichevsky Moscow Research Institute of Epidemiology and Microbiology, Federal Service on Surveillance for Consumer Rights Protection and Human Wellbeing, Moscow, - - 2014
A new universal method for measuring activity of the serum complement system in humans, laboratory, domestic, agricultural animals, birds and amphibians is based on automated evaluation of the mortality of ciliate Tetrahymena pyriformis under the effect of the complement system. In contrast to the hemolytic method, measured activity of the ...
Pinkert Denise D Institut für Chemie, Humboldt-Universität zu Berlin, Brook-Taylor Str. 2, 12489 Berlin (Germany), Fax: - - 2014
Iron centres incorporated in silicate frameworks or located in their pores have been shown to possess unique catalytic properties. As compared to aluminosilicates this area of zeolite chemistry is much younger and in the first part of this review the findings made so far are summarised. Molecular model compounds may ...
Yadav Anand Prakash AP Immunomodulation Laboratory, Defence Institute of Physiology & Allied Sciences, Lucknow Road, Timarpur, Delhi 110054, - - 2014
The Antarctic context is an analogue of space travel, with close similarity in ambience of extreme climate, isolation, constrained living spaces, disrupted sleep cycles, and environmental stress. The present study examined the impact of the harsh habitat of Antarctica on human physiology and its metabolic pathways, by analyzing human serum ...
Zhang Yin-Gang - - 2014
The identification of the cause of chronic low back pain (CLBP) represents a great challenge to orthopedists due to the controversy over the diagnosis of discogenic low back pain (DLBP) and the existence of a number of cases of CLBP of unknown origin. This study aimed to develop diagnostic models ...
Guo Xiuzhi X Department of Laboratory Medicine, Peking Union Medical College Hospital, Chinese Academic Medical Science and Peking Union Medical College, Beijing, P. R. - - 2014
The newly developed glomerular filtration rate (GFR)-estimating equations developed by the CKD-EPI Collaboration and Feng et al. (2013) that are based on standardized serum cystatin C (ScysC), combined/not combined with serum creatinine (Scr), require further validation in China. We compared the performance of four new equations (CKD-EPIcys, CKD-EPIcr-cys, Fengcys, and ...
Frazee Erin N - - 2014
Serum cystatin C can improve glomerular filtration rate (GFR) estimation over creatinine alone, but whether this translates into clinically relevant improvements in drug dosing is unclear. This prospective cohort study enrolled adults receiving scheduled intravenous vancomycin while hospitalized at the Mayo Clinic in 2012. Vancomycin dosing was based on weight, ...
Cios Agnieszka A Department of Pharmacokinetics and Physical Pharmacy, Jagiellonian University, Medical College, 9 Medyczna St, 30-688 Cracow, Poland. Electronic address: - - 2014
The aims of the study were to develop a population pharmacokinetic model of ciprofloxacin (CPX) in the elderly patients and to examine the impact of patient-dependent variables, such as: age, body weight, serum creatinine, creatinine clearance, co-existing diseases and concurrent use of other drugs on pharmacokinetic parameter values of this ...
Zeng Jun - - 2014
Hepatocellular carcinoma (HCC) is one of the most lethal malignancies. The lack of effective screening methods for early diagnosis has been a longstanding bottleneck to improve the survival rate. In the present study, a capillary electrophoresis-time of flight mass spectrometry (CE-TOF/MS)-based metabolomics method was employed to discover novel biomarkers for ...
Kallner Anders A - - 2014
'Clearance' is an accepted surrogate for glomerular filtration rate (GFR) that describes the relation between the serum/plasma concentration of a substance, for example, creatinine, and its urinary excretion rate. On a population level the GFR can be estimated from the creatinine concentration by regression analysis. Such estimates inevitably increase the ...
Lin Wei-Wei WW *Department of Pharmacy, The First Affiliated Hospital, Fujian Medical University, Fuzhou, People's Republic of China; †Department of Neurology, The First Affiliated Hospital, Fujian Medical University, Fuzhou, People's Republic of China; ‡Department of Pharmacy, Huashan Hospital, Fudan University, Shanghai, People's Republic of - - 2014
There are several reports describing population pharmacokinetic (PPK) models of valproic acid (VPA).However, little was known in Chinese adult patients with epilepsy. The present study aimed to establish a PPK model for VPA in Chinese adult epilepsy patients and to demonstrate its use for dose individualisation. Data were obtained from ...
Nezic Lana L Division of Clinical Pharmacology and Toxicology, University Hospital Basel, 4031, Basel, - - 2014
Therapeutic drug monitoring of patients receiving once daily aminoglycoside therapy can be performed using pharmacokinetic (PK) formulas or Bayesian calculations. While these methods produced comparable results, their performance has never been checked against full PK profiles. We performed a PK study in order to compare both methods and to determine ...
Fathi Fariba F Department of Chemistry, Sharif University of Technology, Tehran, - - 2014
The present study was designed to search for metabolic biomarkers and their correlation with serum zinc in Crohn's disease patients. Crohn's disease (CD) is a form of inflammatory bowel disease that may affect any part of the gastrointestinal tract and can be difficult to diagnose using the clinical tests. Thus, ...
Aylward L L LL Summit Toxicology, LLP, 6343 Carolyn Drive, Falls Church, VA 22044, USA. Electronic address: - - 2014
Changes in measured concentrations of persistent compounds such as polychlorinated biphenyls (PCBs) in an individual over time reflect not only intrinsic elimination rates but also any ongoing intake of the compounds and changes in the volume of distribution. Thus, "apparent" elimination rates calculated from data on changes in serum lipid-adjusted ...
Hyltoft Petersen Per P The Norwegian Quality Improvement of Primary Care Laboratories (NOKLUS), Section for General Practice, Department of Public Health and Primary Health Care, Faculty of Medicine and Dentistry, University of Bergen, Norway. Electronic address: - - 2014
Diagnostic decisions based on decision limits according to medical guidelines are different from the majority of clinical decisions due to the strict dichotomization of patients into diseased and non-diseased. Consequently, the influence of analytical performance is more critical than for other diagnostic decisions where much other information is included. The ...
Mihaleva Velitchka V VV Laboratory of Biochemistry, Wageningen University, Dreijenlaan 3, 6703 HA, Wageningen, The Netherlands, - - 2014
An automated quantum mechanical total line shape (QMTLS) fitting model was implemented for quantitative nuclear magnetic resonance (NMR)-based profiling of 42 metabolites in ultrafiltrated human serum samples. Each metabolite was described by a set of chemical shifts, J-couplings, and line widths. These parameters were optimized for each metabolite in each ...
Unice Kenneth M KM Cardno ChemRisk, Pittsburgh, PA 15222. Electronic address: - - 2014
An updated biokinetic model for human exposures to cobalt (Co) was developed based on a comprehensive set of human pharmacokinetics data collected from five male and five female volunteers who ingested ∼1.0 mg Co/day of a Co supplement for three months. Three key experimental observations from the human dosing studies ...
Lin Zhang Z College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, PR - - 2014
Metabolic syndrome (MetS) is a constellation of the most dangerous heart attack risk factors: diabetes and raised fasting plasma glucose, abdominal obesity, high cholesterol and high blood pressure. Analysis and representation of the variances of metabolic profiles is urgently needed for early diagnosis and treatment of MetS. In current study, ...
Mattman Andre A Department of Pathology and Laboratory Medicine, St. Paul's Hospital, University of British Columbia, Vancouver, Canada. Electronic address: - - 2014
IgG4 related disease (IgG4RD) is detected in part by measurement of serum IgG4 levels in patients suspected to have the condition. The immunonephelometric methods that are used to measure serum IgG4 are susceptible to hook effect errors. The quality control parameter IgGRDiff=100* [Sum (IgG1, IgG2, IgG3, IgG4) - Total IgG] ...
Perola Emanuele E Vertex Pharmaceuticals Incorporated, 50 Northern Avenue, Boston, MA 02210, United States. Electronic address: - - 2014
A series of dual targeting inhibitors of bacterial gyrase B and topoisomerase IV were identified and optimized to mid-to-low nanomolar potency against a variety of bacteria. However, in spite of seemingly adequate exposure achieved upon IV administration, the in vivo efficacy of the early lead compounds was limited by high ...
Kohashi Michitaka M Division of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chu-o-ku, Kobe, Hyogo 650-0017, - - 2014
To improve the clinical course of ulcerative colitis (UC), more accurate serum diagnostic and assessment methods are required. We used serum metabolomics to develop diagnostic and assessment methods for UC. Sera from UC patients, Crohn's disease (CD) patients, and healthy volunteers (HV) were collected at multiple institutions. The UC and ...
Diaz-Ledezma Claudio C The Rothman Institute at Thomas Jefferson University, Philadelphia, PA, - - 2014
In the setting of finite healthcare resources, developing cost-efficient strategies for periprosthetic joint infection (PJI) diagnosis is paramount. The current levels of knowledge allow for PJI diagnostic recommendations based on scientific evidence but do not consider the benefits, opportunities, costs, and risks of the different diagnostic alternatives. We determined the ...
Ross H A HA Department of Laboratory Medicine, Laboratory of Genetic, Endocrine and Metabolic diseases, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands. Electronic address: - - 2014
Growth hormone (hGH) is a measurand belonging to ISO category 4, indicating intrinsic unavailability of a reference measurement procedure and primary standard material. Large between-method differences have been raising confusion, especially in the interpretation of results of stimulation tests for exclusion of juvenile growth hormone deficiency. Within the framework of ...
Ten Brink Marloes H MH *Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center; †LAP&P Consultants; and ‡Department of Pediatrics, Leiden University Medical Center, Leiden, The - - 2014
High-dose treosulfan is used in conditioning regimens before hematopoietic stem cell transplantation in children. Pharmacokinetic data to optimize treosulfan dosing are scarce in this patient population. The aims of this study were the development and validation of an analytical method for treosulfan in human serum and the development of a ...
Martus Peter P Institute of Clinical Epidemiology and Medical Biostatistics, UKT Tübingen, Eberhard Karls University - - 2014
Assessment of glomerular filtration rate (GFR) is crucial as the GFR value defines the stage of chronic kidney disease (CKD) and determines the adjustment of drug dosing. The aim was to investigate a new way for the accurate determination of glomerular filtration rate (GFR) in older adults based on the ...
Levey Andrew S AS William B. Schwartz Division of Nephrology, Tufts Medical Center, Department of Medicine, Tufts University School of Medicine, Boston, MA. Electronic address: - - 2014
Estimating glomerular filtration rate (GFR) is essential for clinical practice, research, and public health. Appropriate interpretation of estimated GFR (eGFR) requires understanding the principles of physiology, laboratory medicine, epidemiology, and biostatistics used in the development and validation of GFR estimating equations. Equations developed in diverse populations are less biased at ...
Le Jennifer J *Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla; †Miller Children's Hospital, Long Beach; and ‡Rady Children's Hospital, San Diego, - - 2014
Optimal monitoring of vancomycin in children needs evaluation using the exposure target with area under the curve (AUC) of the serum concentrations versus time over 24 hours. Our study objectives were to: (1) compare the accuracy and precision of vancomycin AUC estimations using 2 sampling strategies-1 serum concentration sample (1S, ...
Conroy Andrea L - - 2014
Dengue fever and leptospirosis have partially overlapping geographic distributions, similar clinical presentations and potentially life-threatening complications but require different treatments. Distinguishing between these cosmopolitan emerging pathogens represents a diagnostic dilemma of global importance. We hypothesized that perturbations in host biomarkers can differentiate between individuals with dengue fever and leptospirosis during ...
Feng Yan Y Bristol-Myers Squibb Company, Princeton, NJ, - - 2014
Ipilimumab is a fully human, monoclonal antibody that blocks cytotoxic T-lymphocyte antigen-4. The objective of the present study was to characterize the clinical pharmacology profile of ipilimumab using a population pharmacokinetic (PPK) approach. The PPK model was developed using 2095 ipilimumab serum concentration values from 499 patients with unresectable stage ...
Roberts Thomas C TC Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom ; Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California, United States of - - 2014
Extracellular microRNAs (miRNAs) are under investigation as minimally-invasive biomarkers for a wide range of disease conditions. We have recently shown in a mouse model of the progressive muscle-wasting condition Duchenne muscular dystrophy (DMD) that a set of highly elevated serum miRNAs reflects the regenerative status of muscle. These miRNAs are ...
Howell B A BA The Hamner-UNC Institute for Drug Safety Sciences, The Hamner Institutes, Research Triangle Park, North Carolina, - - 2014
Entolimod (CBLB502) is a Toll-like receptor 5 agonist in development as a single-dose countermeasure against total body irradiation. Efficacy can be assessed from animal studies, but the "Animal Rule" does not apply to safety assessment. Marked elevations of serum aminotransferases (exceeding 1,000 IU/l) were observed in some human subjects receiving ...
Trujillo-de Santiago Grissel G FEMSA-Biotechnology Center, Monterrey Tech (Centro de Biotecnología-FEMSA, Tecnológico de Monterrey). Ave. Eugenio Garza Sada 2501 sur. Col. Tecnológico, Monterrey, Nuevo León, - - 2014
Contraceptive patches have become a frequently used contraceptive method. We present a mathematical model that describes the serum concentration profiles of Norelgestromin (NGMN) and Ethinylestradiol (EE) released from the contraceptive patch Ortho Evra(®). We propose a simple one-compartment model based on pharmacokinetics data reported in previous studies. The model assumes ...
Buness Andreas A F. Hoffmann-La Roche, Basel, - - 2014
Early and accurate pre-clinical and clinical biomarkers of hepatotoxicity facilitate the drug development process and the safety monitoring in clinical studies. We selected eight known model compounds to be administered to male Wistar rats to identify biomarkers of drug induced liver injury (DILI) using transcriptomics, metabolite profiling (metabolomics) and conventional ...
Boërio Delphine D Department of Neurology, Inselspital, Bern University Hospital and University of Bern, Bern, - - 2014
Hyperkalemia is an important cause of membrane depolarization in renal failure. A recent theoretical model of axonal excitability explains the effects of potassium on threshold electrotonus, but predicts changes in superexcitability in the opposite direction to those observed. To resolve this contradiction we assessed the relationship between serum potassium and ...
Hoppe John M JM Nephrologisches Zentrum, Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, Ludwig-Maximilians-University Munich, Ziemssenstr. 1, 80336, Munich, - - 2014
The nephrotoxic serum nephritis (NTN) model is an integral part of experimental glomerulonephritis (GN) research. Here, we discuss how the murine NTN model can be induced and effectively used to mimic an immune complex-mediated GN. Further, we differentiate between heterologous and autologous models by comparing pathophysiology and phenotypic manifestations.
Song Jue J School of Pharmacy, Anhui Medical University, Meishan Road 81, Hefei, 230032, Anhui, - - 2013
Yu-ping-feng decoction (YPF), a traditional Chinese medicine (TCM) prescription, is widely used to treat some respiratory tract diseases. This study was aimed to set up a pharmacokinetic-pharmacodynamic (PK-PD) model to assess dose-effect relationships for immunomodulatory effects of YPF in rats and to clarify compatibility mechanisms for TCM prescription system. Serum ...
Zhang Xiaohui X College of Environment and Chemical Engineering, Dalian University, Dalian, Liaoning 116622, China. Electronic address: - - 2013
The interaction between 4-thio-5-methyluridine and human serum albumin (HSA) under simulative physiological conditions has been studied by the methods of fluorescence, UV-VIS absorbance and circular dichroism (CD) spectroscopy. The results show that 4-thio-5-methyluridine has a static fluorescence quenching on human serum albumin (HSA). The main forces of both interactions have ...
Bokkhim Huma H The University of Queensland, School of Agriculture and Food Sciences, Brisbane, QLD 4072, Australia. Electronic address: - - 2014
Lactoferrin (Lf) samples with ca. 25%, 50%, 75%, 85% and 100% iron saturation were prepared for the purpose of evaluating Chromametry, Differential Scanning Calorimetry (DSC) and Circular Dichroism (CD) spectropolarimetry for their suitability in determining the iron saturation level. Numerical values for colour from Chromametry, enthalpy change of denaturation (ΔHcal) ...
Gholivand Mohammad-Bagher MB Faculty of Chemistry, Razi University, Kermanshah 671496734, Iran. Electronic address: - - 2014
For the first time, several multivariate calibration (MVC) models including partial least squares-1 (PLS-1), continuum power regression (CPR), multiple linear regression-successive projections algorithm (MLR-SPA), robust continuum regression (RCR), partial robust M-regression (PRM), polynomial-PLS (PLY-PLS), spline-PLS (SPL-PLS), radial basis function-PLS (RBF-PLS), least squares-support vector machines (LS-SVM), wavelet transform-artificial neural network (WT-ANN), ...
Oda Kazutaka - - 2013
The serum level of teicoplanin (TEIC) is immediately elevated following administration of the recommended dose. In this study, the predictability of the serum trough for TEIC was investigated at day 2 or 3 (C2-3), and the authors performed a simulation based on the Bayesian method using C2-3 in Japanese patients. ...
Mayo P R - - 2013
The aims of this population-pharmacokinetic/pharmacodynamic (POP-PKPD) analysis of voclosporin in renal allograft patients were to build a POP-PKPD model for voclosporin and calcineurin activity (CNa) and identify clinically relevant covariates that could assist dosing of the drug. POP-PKPD modeling was performed using a stochastic approximation of the standard expectation maximization ...
Bansal Navneeta - - 2013
To address the shortcomings of urine cytology and cystoscopy for probing and grading of urinary bladder cancer (BC), we applied 1H-nuclear magnetic resonance (NMR) spectroscopy as a surrogate method for identification of BC. This study includes 99 serum samples; comprising low-grade (LG, n=36) and high-grade (HG, n=31) of BC, and ...
Park Hyunjin - - 2013
In the existing compartmental models of human vitamin A metabolism, parameters related to the absorption of the isotopic oral dose have not been well identified. We hypothesised that fixing some poorly identified parameters related to vitamin A absorption would improve parameter identifiability and add statistical certainty to such models. In ...
Chehade Hassib - - 2013
The estimated GFR (eGFR) is important in clinical practice. To find the best formula for eGFR, this study assessed the best model of correlation between sinistrin clearance (iGFR) and the solely or combined cystatin C (CysC)- and serum creatinine (SCreat)-derived models. It also evaluated the accuracy of the combined Schwartz ...
Mitchell Simon - - 2013
Iron is essential for all known life due to its redox properties; however, these same properties can also lead to its toxicity in overload through the production of reactive oxygen species. Robust systemic and cellular control are required to maintain safe levels of iron, and the liver seems to be ...
Casale Teodorico - - 2013
To evaluate whether the exposure to arsenic (As) causes alterations of liver enzymes in two groups of outdoor workers. Total urinary As and the levels of AST/GOT, ALT/GPT, and GGT were measured on 80 traffic policemen and 50 police drivers. Personal air samples were obtained for assessing the exposure to ...
Carobene Anna - - 2013
Creatinine determination in serum is a key indicator of kidney glomerular function. A reference measurement system for its standardization is available and virtually all IVD manufacturers have aligned their assays to this system. In this study, we verified the impact of these standardization efforts on the results of an Italian ...
Murray-Kolb Laura E - - 2013
The purpose of this study is to highlight recent research findings that advance our understanding of the relation between iron status and neural functioning. Recent findings have helped to answer questions pertaining to the interrelationship of iron and neural functioning in three primary areas: reversibility of changes occurring with early-life ...
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