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Ilari-Antoine E E 1The French Pork and Pig Institute (IFIP),Economy Unit,34 Boulevard de la Gare,F-31500 - - 2014
The aim of this paper is to present an efficient tool for evaluating the economy part of the sustainability of pig farming systems. The selected tool IDEA was tested on a sample of farms from 15 contrasted systems in Europe. A statistical analysis was carried out to check the capacity ...
Neumayer Bernhard B Ludwig Boltzmann Institute for Clinical Forensic Imaging, Universitätsplatz 4, A-8010, Graz, - - 2014
In clinical forensic medicine, the estimation of the age of injuries such as externally visible subcutaneous hematomas is important for the reconstruction of violent events, particularly to include or exclude potential suspects. Since the estimation of the time of origin based on external inspection is unreliable, the aim of this ...
Rolletschek Hardy H Leibniz-Institut für Pflanzengenetik und Kulturpflanzenforschung (IPK), Gatersleben, - - 2014
The large numbers of samples processed in breeding and biodiversity programmes require the development of efficient methods for the nondestructive evaluation of basic seed properties. Near-infrared spectroscopy is the state-of-the-art solution for this analytical demand, but it also has some limitations. Here, we present a novel, rapid, accurate procedure based ...
Liu Xuesong X School of Mathematical Science, Dalian University of Technology, Dalian 116024, - - 2014
An evolutionary dynamic model of 2×2 games with finite population of size N+M was built. Among these individuals, N individuals have the same update mechanism as that of Moran process, while the other M individuals have the same update mechanism as that of Fermi process. We obtain the balance equations ...
Gayetskyy Svitlana - - 2014
Angiogenesis is an important pathophysiological process of chronic inflammation, especially in inflammatory arthritis. Quantitative measurement of changes in vascularization may improve the diagnosis and monitoring of arthritis. The aim of this work is the development of a 3D imaging and analysis framework for quantification of vascularization in experimental arthritis. High-resolution ...
Kellman Peter P National Heart, Lung, and Blood Institute, National Institutes of Health, DHHS, 10 Center Drive MSC-1061, Bethesda 20892, MD, USA. - - 2014
T1-mapping has the potential to detect and quantify diffuse processes such as interstitial fibrosis. Detection of disease at an early stage by measurement of subtle changes requires a high degree of reproducibility. Initial implementation of saturation recovery (SR) T1-mapping employed 3-parameter fitting which was highly accurate but was quite sensitive ...
Mitra Amitava A Biopharmaceutics, Pharmaceutical Sciences and Clinical Supply, Merck & Co. Inc, West Point, Pennsylvania, 19486, USA, - - 2014
As part of the overall product development and manufacturing strategy, pharmaceutical companies routinely change formulation and manufacturing site. Depending on the type and level of change and the BCS class of the molecule, dissolution data and/or bioequivalence (BE) may be needed to support the change for immediate release dosage forms. ...
Dioury Fabienne - - 2014
Gadolinium(III) complexes constitute the largest class of compounds used as contrast agents for Magnetic Resonance Imaging (MRI). A quantitative structure-property relationship (QSPR) machine-learning based method is applied to predict the thermodynamic stability constants of these complexes (log KGdL), a property commonly associated with the toxicity of such organometallic pharmaceuticals. In ...
Sawa Koji K Senior High School, Japan Women's University, Tama, Kawasaki 214-8565, Japan. Electronic address: - - 2014
In this paper, we mainly address three issues: externality of an agent, purpose of an agent, and a kind of "softness" of components in a system. Agents are independent of a system in an ordinary multi-agent model, hence the behavior of a system is not autonomous but influenced by the ...
Gebauer Jochen E - - 2014
A sociocultural motives perspective (SMP) on Big Five relationships is introduced. According to the SMP, Agreeableness and Conscientiousness elicit assimilation to sociocultural norms, Openness elicits contrast from these norms, and Extraversion and Neuroticism are independent of sociocultural assimilation and contrast. Due to sociocultural assimilation, then, relationships of Agreeableness and Conscientiousness ...
Zhao Bo B Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA; Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, Illinois, - - 2014
To enable accurate magnetic resonance (MR) parameter mapping with accelerated data acquisition, utilizing recent advances in constrained imaging with sparse sampling. A new constrained reconstruction method based on low-rank and sparsity constraints is proposed to accelerate MR parameter mapping. More specifically, the proposed method simultaneously imposes low-rank and joint sparse ...
Weidner Christopher C Otto Warburg Laboratory, Max Planck Institute for Molecular Genetics, Ihnestrasse 63-73, 14195 Berlin, - - 2014
Summary: We introduce PHOXTRACK (PHOsphosite-X-TRacing Analysis of Causal Kinases), a user-friendly, freely available software tool for analysing large data sets of post-translational modifications of proteins such as phosphoryla-tion, which are commonly gained by mass spectrometry detection. In contrast to other currently applied data analysis approaches, PHOXTRACK uses full sets of ...
Estellon Johan J Univ. Grenoble Alpes, iRTSV-BGE, F-38000 Grenoble, France. - - 2014
Metalloproteins represent a ubiquitous group of molecules which are crucial to the survival of all living organisms. While several metal-binding motifs have been defined, it remains challenging to confidently identify metalloproteins from primary protein sequences using computational approaches alone. Here, we describe a comprehensive strategy based on a machine learning ...
Leow Melvin Khee-Shing - - 2014
Despite rendering serum free thyroxine (FT4) and thyrotropin (TSH) within the normal population ranges broadly defined as euthyroidism, many patients being treated for hyperthyroidism and hypothyroidism persistently experience subnormal well-being discordant from their pre-disease healthy euthyroid state. This suggests that intra-individual physiological optimal ranges are narrower than laboratory-quoted normal ranges ...
Zaidi Ali H AH Institute for the Treatment of Esophageal and Thoracic Disease, Allegheny Health Network, Pittsburgh, - - 2014
Esophageal adenocarcinoma (EAC) is associated with a dismal prognosis. The identification of cancer biomarkers can advance the possibility for early detection and better monitoring of tumor progression and/or response to therapy. The authors present results from the development of a serum-based, 4-protein (biglycan, myeloperoxidase, annexin-A6, and protein S100-A9) biomarker panel ...
Cataldo Salvatore S Dipartimento di Fisica e Chimica, Università degli Studi di Palermo, Viale delle Scienze, I-90128 Palermo, - - 2014
Systematic kinetic and equilibrium studies on the lead ions removal ability by Ca-alginate gel beads have been performed by varying several internal parameters, namely, number of gel beads, nature and composition of the ionic medium and pH, which allowed us to model a wastewater in order to closely reproduce the ...
Merrill Scott C - - 2014
The Russian wheat aphid, Diuraphis noxia (Kurdjumov) is a serious pest of small grains, such as wheat and barley. High population growth rates and a broad gramineae host range have allowed this aphid to successfully establish and become pestiferous across much of North America since its invasion in the mid-1980s. ...
Mader Malenka M Department of Neuropediatrics and Muscular Disease, University Medical Center of Freiburg, Freiburg, Germany and Freiburg Center for Data Analysis and Modeling (FDM), University of Freiburg, Freiburg, Germany and Institute for Physics, University of Freiburg, Freiburg, Germany and Center for Neural Engineering, Pennsylvania State University, State College, Pennsylvania 16801, USA and Department of Engineering Science and Mechanics, Pennsylvania State University, State College, Pennsylvania 16801, - - 2014
Reliable forecasts of extreme but rare events, such as earthquakes, financial crashes, and epileptic seizures, would render interventions and precautions possible. Therefore, forecasting methods have been developed which intend to raise an alarm if an extreme event is about to occur. In order to statistically validate the performance of a ...
O'Bryant Sid E SE Department of Internal Medicine, University of North Texas Health Science Center, Fort Worth, TX, USA Institute for Aging & Alzheimer's Disease Research, University of North Texas Health Science Center, Fort Worth, TX, - - 2014
Background: There is a significant need for rapid and cost-effective biomarkers of Alzheimer's disease (AD) for advancement of clinical practice and therapeutic trials. Objective: The aim of the current study was to cross-validate our previously published serum-based algorithm on an independent assay platform as well as validate across tissues and ...
Zhang Yi Y Genentech, Inc., South San Francisco, - - 2014
To describe the systemic pharmacokinetics of ranibizumab after intravitreal administration in patients with retinal vein occlusion (RVO) or diabetic macular edema (DME). A population approach of nonlinear mixed-effect pharmacokinetics modeling based on serum concentrations of ranibizumab measured at various times after intravitreal administration. Patients with RVO (n = 441) and ...
Potdar Alka A AA Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, United States of America; Department of Cellular and Molecular Medicine, Cleveland Clinic, Cleveland, Ohio, United States of - - 2014
A major process of iron homeostasis in whole-body iron metabolism is the release of iron from the macrophages of the reticuloendothelial system. Macrophages recognize and phagocytose senescent or damaged erythrocytes. Then, they process the heme iron, which is returned to the circulation for reutilization by red blood cell precursors during ...
Kuleshina O N ON G. N. Gabrichevsky Moscow Research Institute of Epidemiology and Microbiology, Federal Service on Surveillance for Consumer Rights Protection and Human Wellbeing, Moscow, - - 2014
A new universal method for measuring activity of the serum complement system in humans, laboratory, domestic, agricultural animals, birds and amphibians is based on automated evaluation of the mortality of ciliate Tetrahymena pyriformis under the effect of the complement system. In contrast to the hemolytic method, measured activity of the ...
Pinkert Denise D Institut für Chemie, Humboldt-Universität zu Berlin, Brook-Taylor Str. 2, 12489 Berlin (Germany), Fax: - - 2014
Iron centres incorporated in silicate frameworks or located in their pores have been shown to possess unique catalytic properties. As compared to aluminosilicates this area of zeolite chemistry is much younger and in the first part of this review the findings made so far are summarised. Molecular model compounds may ...
Yadav Anand Prakash AP Immunomodulation Laboratory, Defence Institute of Physiology & Allied Sciences, Lucknow Road, Timarpur, Delhi 110054, - - 2014
The Antarctic context is an analogue of space travel, with close similarity in ambience of extreme climate, isolation, constrained living spaces, disrupted sleep cycles, and environmental stress. The present study examined the impact of the harsh habitat of Antarctica on human physiology and its metabolic pathways, by analyzing human serum ...
Zhang Yin-Gang - - 2014
The identification of the cause of chronic low back pain (CLBP) represents a great challenge to orthopedists due to the controversy over the diagnosis of discogenic low back pain (DLBP) and the existence of a number of cases of CLBP of unknown origin. This study aimed to develop diagnostic models ...
Guo Xiuzhi X Department of Laboratory Medicine, Peking Union Medical College Hospital, Chinese Academic Medical Science and Peking Union Medical College, Beijing, P. R. - - 2014
The newly developed glomerular filtration rate (GFR)-estimating equations developed by the CKD-EPI Collaboration and Feng et al. (2013) that are based on standardized serum cystatin C (ScysC), combined/not combined with serum creatinine (Scr), require further validation in China. We compared the performance of four new equations (CKD-EPIcys, CKD-EPIcr-cys, Fengcys, and ...
Frazee Erin N - - 2014
Serum cystatin C can improve glomerular filtration rate (GFR) estimation over creatinine alone, but whether this translates into clinically relevant improvements in drug dosing is unclear. This prospective cohort study enrolled adults receiving scheduled intravenous vancomycin while hospitalized at the Mayo Clinic in 2012. Vancomycin dosing was based on weight, ...
Cios Agnieszka A Department of Pharmacokinetics and Physical Pharmacy, Jagiellonian University, Medical College, 9 Medyczna St, 30-688 Cracow, Poland. Electronic address: - - 2014
The aims of the study were to develop a population pharmacokinetic model of ciprofloxacin (CPX) in the elderly patients and to examine the impact of patient-dependent variables, such as: age, body weight, serum creatinine, creatinine clearance, co-existing diseases and concurrent use of other drugs on pharmacokinetic parameter values of this ...
Zeng Jun - - 2014
Hepatocellular carcinoma (HCC) is one of the most lethal malignancies. The lack of effective screening methods for early diagnosis has been a longstanding bottleneck to improve the survival rate. In the present study, a capillary electrophoresis-time of flight mass spectrometry (CE-TOF/MS)-based metabolomics method was employed to discover novel biomarkers for ...
Kallner Anders A - - 2014
'Clearance' is an accepted surrogate for glomerular filtration rate (GFR) that describes the relation between the serum/plasma concentration of a substance, for example, creatinine, and its urinary excretion rate. On a population level the GFR can be estimated from the creatinine concentration by regression analysis. Such estimates inevitably increase the ...
Lin Wei-Wei WW *Department of Pharmacy, The First Affiliated Hospital, Fujian Medical University, Fuzhou, People's Republic of China; †Department of Neurology, The First Affiliated Hospital, Fujian Medical University, Fuzhou, People's Republic of China; ‡Department of Pharmacy, Huashan Hospital, Fudan University, Shanghai, People's Republic of - - 2014
There are several reports describing population pharmacokinetic (PPK) models of valproic acid (VPA).However, little was known in Chinese adult patients with epilepsy. The present study aimed to establish a PPK model for VPA in Chinese adult epilepsy patients and to demonstrate its use for dose individualisation. Data were obtained from ...
Nezic Lana L Division of Clinical Pharmacology and Toxicology, University Hospital Basel, 4031, Basel, - - 2014
Therapeutic drug monitoring of patients receiving once daily aminoglycoside therapy can be performed using pharmacokinetic (PK) formulas or Bayesian calculations. While these methods produced comparable results, their performance has never been checked against full PK profiles. We performed a PK study in order to compare both methods and to determine ...
Fathi Fariba F Department of Chemistry, Sharif University of Technology, Tehran, - - 2014
The present study was designed to search for metabolic biomarkers and their correlation with serum zinc in Crohn's disease patients. Crohn's disease (CD) is a form of inflammatory bowel disease that may affect any part of the gastrointestinal tract and can be difficult to diagnose using the clinical tests. Thus, ...
Aylward L L LL Summit Toxicology, LLP, 6343 Carolyn Drive, Falls Church, VA 22044, USA. Electronic address: - - 2014
Changes in measured concentrations of persistent compounds such as polychlorinated biphenyls (PCBs) in an individual over time reflect not only intrinsic elimination rates but also any ongoing intake of the compounds and changes in the volume of distribution. Thus, "apparent" elimination rates calculated from data on changes in serum lipid-adjusted ...
Hyltoft Petersen Per P The Norwegian Quality Improvement of Primary Care Laboratories (NOKLUS), Section for General Practice, Department of Public Health and Primary Health Care, Faculty of Medicine and Dentistry, University of Bergen, Norway. Electronic address: - - 2014
Diagnostic decisions based on decision limits according to medical guidelines are different from the majority of clinical decisions due to the strict dichotomization of patients into diseased and non-diseased. Consequently, the influence of analytical performance is more critical than for other diagnostic decisions where much other information is included. The ...
Mihaleva Velitchka V VV Laboratory of Biochemistry, Wageningen University, Dreijenlaan 3, 6703 HA, Wageningen, The Netherlands, - - 2014
An automated quantum mechanical total line shape (QMTLS) fitting model was implemented for quantitative nuclear magnetic resonance (NMR)-based profiling of 42 metabolites in ultrafiltrated human serum samples. Each metabolite was described by a set of chemical shifts, J-couplings, and line widths. These parameters were optimized for each metabolite in each ...
Unice Kenneth M KM Cardno ChemRisk, Pittsburgh, PA 15222. Electronic address: - - 2014
An updated biokinetic model for human exposures to cobalt (Co) was developed based on a comprehensive set of human pharmacokinetics data collected from five male and five female volunteers who ingested ∼1.0 mg Co/day of a Co supplement for three months. Three key experimental observations from the human dosing studies ...
Lin Zhang Z College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, PR - - 2014
Metabolic syndrome (MetS) is a constellation of the most dangerous heart attack risk factors: diabetes and raised fasting plasma glucose, abdominal obesity, high cholesterol and high blood pressure. Analysis and representation of the variances of metabolic profiles is urgently needed for early diagnosis and treatment of MetS. In current study, ...
Mattman Andre A Department of Pathology and Laboratory Medicine, St. Paul's Hospital, University of British Columbia, Vancouver, Canada. Electronic address: - - 2014
IgG4 related disease (IgG4RD) is detected in part by measurement of serum IgG4 levels in patients suspected to have the condition. The immunonephelometric methods that are used to measure serum IgG4 are susceptible to hook effect errors. The quality control parameter IgGRDiff=100* [Sum (IgG1, IgG2, IgG3, IgG4) - Total IgG] ...
Perola Emanuele E Vertex Pharmaceuticals Incorporated, 50 Northern Avenue, Boston, MA 02210, United States. Electronic address: - - 2014
A series of dual targeting inhibitors of bacterial gyrase B and topoisomerase IV were identified and optimized to mid-to-low nanomolar potency against a variety of bacteria. However, in spite of seemingly adequate exposure achieved upon IV administration, the in vivo efficacy of the early lead compounds was limited by high ...
Kohashi Michitaka M Division of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chu-o-ku, Kobe, Hyogo 650-0017, - - 2014
To improve the clinical course of ulcerative colitis (UC), more accurate serum diagnostic and assessment methods are required. We used serum metabolomics to develop diagnostic and assessment methods for UC. Sera from UC patients, Crohn's disease (CD) patients, and healthy volunteers (HV) were collected at multiple institutions. The UC and ...
Diaz-Ledezma Claudio C The Rothman Institute at Thomas Jefferson University, Philadelphia, PA, - - 2014
In the setting of finite healthcare resources, developing cost-efficient strategies for periprosthetic joint infection (PJI) diagnosis is paramount. The current levels of knowledge allow for PJI diagnostic recommendations based on scientific evidence but do not consider the benefits, opportunities, costs, and risks of the different diagnostic alternatives. We determined the ...
Ross H A HA Department of Laboratory Medicine, Laboratory of Genetic, Endocrine and Metabolic diseases, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands. Electronic address: - - 2014
Growth hormone (hGH) is a measurand belonging to ISO category 4, indicating intrinsic unavailability of a reference measurement procedure and primary standard material. Large between-method differences have been raising confusion, especially in the interpretation of results of stimulation tests for exclusion of juvenile growth hormone deficiency. Within the framework of ...
Ten Brink Marloes H MH *Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center; †LAP&P Consultants; and ‡Department of Pediatrics, Leiden University Medical Center, Leiden, The - - 2014
High-dose treosulfan is used in conditioning regimens before hematopoietic stem cell transplantation in children. Pharmacokinetic data to optimize treosulfan dosing are scarce in this patient population. The aims of this study were the development and validation of an analytical method for treosulfan in human serum and the development of a ...
Martus Peter P Institute of Clinical Epidemiology and Medical Biostatistics, UKT Tübingen, Eberhard Karls University - - 2014
Assessment of glomerular filtration rate (GFR) is crucial as the GFR value defines the stage of chronic kidney disease (CKD) and determines the adjustment of drug dosing. The aim was to investigate a new way for the accurate determination of glomerular filtration rate (GFR) in older adults based on the ...
Levey Andrew S AS William B. Schwartz Division of Nephrology, Tufts Medical Center, Department of Medicine, Tufts University School of Medicine, Boston, MA. Electronic address: - - 2014
Estimating glomerular filtration rate (GFR) is essential for clinical practice, research, and public health. Appropriate interpretation of estimated GFR (eGFR) requires understanding the principles of physiology, laboratory medicine, epidemiology, and biostatistics used in the development and validation of GFR estimating equations. Equations developed in diverse populations are less biased at ...
Le Jennifer J *Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla; †Miller Children's Hospital, Long Beach; and ‡Rady Children's Hospital, San Diego, - - 2014
Optimal monitoring of vancomycin in children needs evaluation using the exposure target with area under the curve (AUC) of the serum concentrations versus time over 24 hours. Our study objectives were to: (1) compare the accuracy and precision of vancomycin AUC estimations using 2 sampling strategies-1 serum concentration sample (1S, ...
Conroy Andrea L - - 2014
Dengue fever and leptospirosis have partially overlapping geographic distributions, similar clinical presentations and potentially life-threatening complications but require different treatments. Distinguishing between these cosmopolitan emerging pathogens represents a diagnostic dilemma of global importance. We hypothesized that perturbations in host biomarkers can differentiate between individuals with dengue fever and leptospirosis during ...
Feng Yan Y Bristol-Myers Squibb Company, Princeton, NJ, - - 2014
Ipilimumab is a fully human, monoclonal antibody that blocks cytotoxic T-lymphocyte antigen-4. The objective of the present study was to characterize the clinical pharmacology profile of ipilimumab using a population pharmacokinetic (PPK) approach. The PPK model was developed using 2095 ipilimumab serum concentration values from 499 patients with unresectable stage ...
Roberts Thomas C TC Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom ; Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California, United States of - - 2014
Extracellular microRNAs (miRNAs) are under investigation as minimally-invasive biomarkers for a wide range of disease conditions. We have recently shown in a mouse model of the progressive muscle-wasting condition Duchenne muscular dystrophy (DMD) that a set of highly elevated serum miRNAs reflects the regenerative status of muscle. These miRNAs are ...
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