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Liu Xiaoyu X School of Biological sSience and Medical Engineering, School of Biological Science and Medical Engineering, Beihang University, No.37, Xueyuan Road, Beijing, 100191, China, Beijing, 100191, - - 2014
Purpose: To develop a mechanical model to investigate the relationship between the crimping morphology of collagen fibrils and the nonlinear mechanical behavior of the cornea. Methods: Uniaxial tensile experiments were performed on corneal strips to test the mechanical behavior. A constitutive model was constructed based on the Gaussian-distributed morphology of ...
Rohou Alexis A Department of Biochemistry, Rosenstiel Basic Medical Sciences Research Center, Brandeis University, Waltham, MA 02454, USA; Janelia Farm Research Campus, Howard Hughes Medical Institute, 19700 Helix Drive, Ashburn, VA 20147, - - 2014
The structures of many helical protein filaments can be derived from electron micrographs of their suspensions in thin films of vitrified aqueous solutions. The most successful and generally-applicable approach treats short segments of these filaments as independent "single particles", yielding near-atomic resolution for rigid and well-ordered filaments. The single-particle approach ...
Szczesny Spencer E SE Department of Bioengineering, University of Pennsylvania, 240 Skirkanich Hall, 210 South 33rd St, Philadelphia, PA 19104. Electronic address: - - 2014
Despite the critical role tendons play in transmitting loads throughout the musculoskeletal system, little is known about the microstructural mechanisms underlying their mechanical function. Of particular interest is whether collagen fibrils in tendon fascicles bear load independently or if load is transferred between fibrils through interfibrillar shear forces. We conducted ...
Xue Wei-Feng WF School of Biosciences, University of Kent, Canterbury, United Kingdom; Astbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, United Kingdom. Electronic address: - - 2013
Delineating the nanoscale properties and the dynamic assembly and disassembly behaviors of amyloid fibrils is key for technological applications that use the material properties of amyloid fibrils, as well as for developing treatments of amyloid-associated disease. However, quantitative mechanistic understanding of the complex processes involving these heterogeneous supramolecular systems presents ...
Reinhardt James - - 2013
Agent-based modeling was used to model collagen fibrils, composed of a string of nodes serially connected by links that act as Hookean springs. Bending mechanics are implemented as torsional springs that act upon each set of three serially connected nodes as a linear function of angular deflection about the central ...
Inshyn DI - - 2013
Quantitative structure activity relationship (QSAR) studies were performed on a set of polymethine compounds to develop new fluorescent probes for detecting amyloid fibrils. Two different approaches were evaluated for developing a predictive model: part least squares (PLS) regression and an artificial neural network (ANN). A set of 60 relevant molecular ...
Wells Hannah C - - 2013
The main structural component of leather and skin is type I collagen in the form of strong fibrils. Strength is an important property of leather, and the way in which collagen contributes to the strength is not fully understood. Synchrotron-based small angle X-ray scattering (SAXS) is used to measure the ...
Tan Pengzhen - - 2013
During the application of the mass-action-equation models to the study of amyloid fiber formation, time-consuming numerical calculations constitute a major bottleneck. To conquer this difficulty, here an alternative efficient method is introduced for the fragmentation-only model. It includes two basic steps: (1) simulate close-formed time-evolutionary equations for the number concentration ...
Gillam J E - - 2013
Amyloid and amyloid-like fibrils are self-assembling protein nanostructures, of interest for their robust material properties and inherent biological compatibility as well as their putative role in a number of debilitating mammalian disorders. Understanding fibril formation is essential to the development of strategies to control, manipulate or prevent fibril growth. As ...
Yang Sichun - - 2013
We examine the energetics of ß-strand packing in a fibril-forming SH3 domain using a simple sequence-based energy model. First, we describe the packing energy model and then apply it to three model systems: the SH3 domain of PI3 kinase, the Aß peptide, and the HET-s prion. The packing results of ...
Andrikopoulos George K - - 2013
The objective of the present study was to evaluate, from an economic perspective, dabigatran etexilate in comparison to existing pharmaceutical therapeutic options available for the protection of moderate-to-high risk patients with non-valvular atrial fibrillation from cardioembolic risk. An existing Markov model was adapted to the Greek setting to reflect the ...
Co Nguyen Truong - - 2013
We have developed the lattice model for describing polypeptide chains in the presence of crowders. The influence of crowding confinement on the fibrillation kinetics of polypeptide chains is studied using this model. We observed the non-trivial behavior of the fibril formation time τfib that it decreases with the concentration of ...
Mononen Mika E - - 2013
Computational models can be used to evaluate the functional properties of knee joints and possible risk locations within joints. Current models with fibril-reinforced cartilage layers do not provide information about realistic human movement during walking. This study aimed to evaluate stresses and strains within a knee joint by implementing load ...
Nickien Mieke - - 2013
The primary structural components of articular cartilage are the zonally differentiated interconnected network of collagen fibrils and proteoglycans, the latter having the potential to bind large amounts of water. Both components exist in a coupled relationship that gives rise to its remarkable mechanical properties. The response of cartilage to compression ...
Kaneko Masato - - 2013
This study was designed to confirm the appropriateness of the dose setting for a Japanese phase III study of rivaroxaban in patients with non-valvular atrial fibrillation (NVAF), which had been based on model simulation employing phase II study data. The previously developed mixed-effects pharmacokinetic/pharmacodynamic (PK-PD) model, which consisted of an ...
González-Juanatey José R - - 2012
INTRODUCTION AND OBJECTIVES: Assessment of the cost-effectiveness of dabigatran for the prevention of stroke and systemic embolism in patients with non-valvular atrial fibrillation in Spain, from the perspective of the National Health System. METHODS: Adaptation of a Markov chain model that simulates the natural history of the disease over the ...
Mezentseva L V - - 2012
Electrical activity of the heart during ventricular fibrillation was modeled as a sum of N independent pulse streams with various amplitude-frequency and phase characteristics. The data of computational experiments were compared with the results of actual physiological experiments on dogs. Identification of the model was performed using the least square ...
Sereinigg M - - 2012
Due to the lack of human donors, several strategies have sought to expand the organ pool. Efforts to characterize donation after cardiac death (DCD) have included studies of cell viability, histological and immunohistochemical changes, and oxidative stress, which is known to negatively impact graft survival. A large animal model would ...
Larue Lionel - - 2012
Melanoblasts are a particular type of cell that displays extensive cellular proliferation during development to contribute to the skin. There are only a few melanoblast founders, initially located just dorsal to the neural tube, and they sequentially colonize the dermis, epidermis, and hair follicles. In each compartment, melanoblasts are exposed ...
Simakov David S A - - 2012
Similar to other organisms, Drosophila uses its Epidermal Growth Factor Receptor (EGFR) multiple times throughout development. One crucial EGFR-dependent event is patterning of the follicular epithelium during oogenesis. In addition to providing inductive cues necessary for body axes specification, patterning of the follicle cells initiates the formation of two respiratory ...
Boer H M T - - 2012
The complex interplay of physiological factors that underlies fertility in dairy cows was investigated using a mechanistic mathematical model of the dynamics of the bovine estrous cycle. The model simulates the processes of follicle and corpus luteum development and its relations with key hormones that interact to control these processes. ...
Izumi Tokukazu - - 2012
The relationship between the growth of preantral and antral follicles and that of their oocytes in ovaries of domestic cats (Felis catus) was analyzed. Eight hundred and five pairs of follicles and oocytes from the ovaries of 51 female cats were collected, and only healthy and fresh follicles and oocytes ...
Rodgers Gregory B - - 2012
ObjectiveTo evaluate the effectiveness of the immersion protection requirements of a voluntary safety standard for portable handheld hair dryers in preventing electrocution deaths in the USA.MethodsThe present work was an interrupted time series study design. Data on annual hair dryer-related electrocution deaths resulting from water contact were developed for the ...
Hoffman Gloria E - - 2012
FMR1 premutation (PM) alleles have 55-200 CGG·CCG-repeats in their 5' UTR. PM carriers are at risk of fragile X-associated tremor and ataxia syndrome (FXTAS). Females are also at risk for FX primary ovarian insufficiency (FXPOI). PM pathology is generally attributed to deleterious properties of transcripts with long CGG-tracts. For FXPOI, ...
Meaud Julien J Department of Mechanical Engineering, University of Michigan, Ann Arbor, Michigan, - - 2012
In this article, a nonlinear mathematical model is developed based on the physiology of the cochlea of the guinea pig. The three-dimensional intracochlear fluid dynamics are coupled to a micromechanical model of the organ of Corti and to electrical potentials in the cochlear ducts and outer hair cells (OHC). OHC ...
Ramamoorthy Sripriya - - 2012
The active amplification of sound-induced vibrations in the cochlea, known to be crucial for auditory sensitivity and frequency selectivity, is not well understood. The outer hair cell (OHC) somatic electromotility is a potential mechanism for such amplification. Its effectiveness in vivo is putatively limited by the electrical low-pass filtering of the cell's ...
Lademann J - - 2012
Bacteria and fungi are located in the stratum corneum and the hair follicles. Therefore, the development and assessment of efficient drugs requires standard in vivo investigation methods permitting a differentiation between intercellular and follicular penetration and storage of topically applied anti-microbial substances. In the present study, the penetration and storage ...
Josefsson Anders - - 2012
The alpha particle emitter 211At is proposed for therapy of metastatic tumour disease. 211At is accumulated in the thyroid gland in a similar way as iodine. Dosimetric models of 211At in the thyroid are needed for radiation protection assessments for 1) patients receiving 211At-labelled pharmaceuticals where 211At may be released ...
Ablitzer Frédéric - - 2012
Experienced bow makers empirically know the influence of wood, tapering, and camber on the playing and tonal qualities of a bow. However, the way each parameter affects the bow mechanical behavior is not clearly established. An in-plane finite element model is developed to highlight the link between the adjustable design ...
Kelsey Thomas W - - 2012
A reliable indirect measure of ovarian reserve for the individual woman remains a challenge for reproductive specialists. Using descriptive statistics from a large-scale study of ovarian volumes, we have developed a normative model for healthy females for ages 25 through 85. For average values, this model has a strong and ...
Vilar Luís - - 2012
Performance analysis is a subdiscipline of sports sciences and one-approach, notational analysis, has been used to objectively audit and describe behaviours of performers during different subphases of play, providing additional information for practitioners to improve future sports performance. Recent criticisms of these methods have suggested the need for a sound ...
Fragoulakis Vassilis - - 2012
The purpose of this study was to compare Gonal-F(®), a recombinant follicle-stimulating hormone, with Menopur(®), a highly purified human menopausal gonadotrophin (hpHMG) in assisted reproduction in Greece. A decision tree in combination with a Markov model was used to assess the clinical and economical impact of comparators for up to ...
Paredes Jose M - - 2012
Amyloidogenic protein aggregation is a persistent biomedical problem. Despite active research in disease-related aggregation, the need for multidisciplinary approaches to the problem is evident. Recent advances in single-molecule fluorescence spectroscopy are valuable for examining heterogenic biomolecular systems. In this work, we have explored the initial stages of amyloidogenic aggregation by ...
Popa-Lisseanu Ana G - - 2012
Despite a commitment by the European Union to protect its migratory bat populations, conservation efforts are hindered by a poor understanding of bat migratory strategies and connectivity between breeding and wintering grounds. Traditional methods like mark-recapture are ineffective to study broad-scale bat migratory patterns. Stable hydrogen isotopes (δD) have been ...
Sawaya Michael A - - 2012
We evaluated the potential of two noninvasive genetic sampling methods, hair traps and bear rub surveys, to estimate population abundance and trend of grizzly (Ursus arctos) and black bear (U. americanus) populations in Banff National Park, Alberta, Canada. Using Huggins closed population mark-recapture models, we obtained the first precise abundance ...
Ginter Carly C - - 2012
Vibrissae (whiskers) are important components of the mammalian tactile sensory system, and primarily function as detectors of vibrotactile information from the environment. Pinnipeds possess the largest vibrissae among mammals and their vibrissal hair shafts demonstrate a diversity of shapes. The vibrissae of most phocid seals exhibit a beaded morphology with ...
Marcelino Rui O - - 2011
The purpose of this study was to examine attack and serve performancesin the beginning and end of the initial and final sets of volleyball matches according to the quality of opposition. Six hundred rallies from the Men's World Cup 2007 were selectively sampled from a total of five thousand one ...
Sanchez-Anguix Victor - - 2011
In this article, an agent-based negotiation model for negotiation teams that negotiate a deal with an opponent is presented. Agent-based negotiation teams are groups of agents that join together as a single negotiation party because they share an interest that is related to the negotiation process. The model relies on ...
De Jong Bart A - - 2012
Past research has implicitly assumed that only mean levels of trust and monitoring in teams are critical for explaining their interrelations and their relationships with team performance. In this article, the authors argue that it is equally important to consider the dispersion in trust and monitoring that exists within teams. ...
Barbosa A - - 2011
The main purpose of this study is to investigate the existence of behaviour patterns that repeat seven times Offensive Process in Spanish league 2010/2011 Season. To collect data, we used the instrument validated by Sarmento et al (2010). This instrument consists of a specific notational system to study the offensive ...
Valero-Gomez Alberto - - 2011
The aim of this study was to evaluate two models for adjusting autonomy in mobile robots to find out the best way for the operator to interact with the system with as many robots as possible. The first model is the most used in mobile robots; the second proposes a ...
Dutt-Mazumder Aviroop - - 2011
Recent studies have explored the organization of player movements in team sports using a range of statistical tools. However, the factors that best explain the performance of association football teams remain elusive. Arguably, this is due to the high-dimensional behavioural outputs that illustrate the complex, evolving configurations typical of team ...
Harvey Carol - - 2011
The impact of variable implementation of the Assertive Community Treatment (ACT) model on patient outcomes is increasingly recognised. We conducted the first study of four established Australian ACT teams, examining team composition, processes and model fidelity, using previously validated questionnaires. Demographic and clinical details of patients and their own experiences ...
Kamath Y K - - 2011
Literature dealing with the mechanisms of hair breakage in combing and brushing published so far has been reviewed as a background for the critical evaluation of the method and data analysis of the paper "Statistical Analysis of Hair Breakage. II" by Evans and Park (1). Accumulated knowledge about hair breakage ...
Dutt-Mazumder Aviroop - - 2011
Recent studies have explored the organization of player movements in team sports using a range of statistical tools. However, the factors that best explain the performance of association football teams remain elusive. Arguably, this is due to the high-dimensional behavioural outputs that illustrate the complex, evolving configurations typical of team ...
Wang Yue - - 2011
MOTIVATION: Many new methods have recently been proposed for detecting epistatic interactions in GWAS data. There is however no in-depth independent comparison of these methods yet. RESULTS: Five recent methods-TEAM, BOOST, SNPHarvester, SNPRuler, and Screen and Clean (SC)-are evaluated here in terms of power, type-1 error rate, scalability, and completeness. ...
Balkundi Prasad - - 2011
When leaders interact in teams with their subordinates, they build social capital that can have positive effects on team performance. Does this social capital affect team performance because subordinates come to see the leader as charismatic? We answered this question by examining 2 models. First, we tested the charisma-to-centrality model ...
Guziolowski Carito - - 2011
We discuss the propagation of constraints in eukaryotic interaction networks in relation to model prediction and the identification of critical pathways. In order to cope with posttranslational interactions, we consider two types of nodes in the network, corresponding to proteins and to RNA. Microarray data provides very lacunar information for ...
John David J DJ Department of Computer Science, Wake Forest University, Winston-Salem, NC 27106, USA. - - 2011
Modeling of biological networks is a difficult endeavor, but exploration of this problem is essential for understanding the systems behavior of biological processes. In this contribution, developed for sparse data, we present a new continuous Bayesian graphical learning algorithm to cotemporally model proteins in signaling networks and genes in transcriptional ...
Winskog Calle - - 2011
Human trafficking of young men from Africa to Europe is a crime with often devastating consequences. The African continent loses members of the younger generation and many die during the attempt to reach their destinations. The identification of these victims is often difficult, however the structured and by now well-established ...
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