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Storer Robin James RJ Department of Physiology, Faculty of Medicine, Chulalongkorn University, Pathumwan, Bangkok, 10330, Thailand, - - 2015
Many animal models of migraine have been described. Some of them have been useful in the development of new therapies. All of them have their shortcomings. Animal models of chronic migraine have been relatively less frequently described. Whether a rigid distinction between episodic and chronic migraine is useful when their ...
Tang Jinsong J Institute of Mental Health, The Second Xiangya Hospital of Central South University, Changsha, Hunan, 410011, People's Republic of - - 2014
Subanaesthetic ketamine infusion in healthy volunteers induces experiences redolent of early psychosis, including changes in the experience of one's own body. It is not clear, however, whether repeated self-administration of ketamine has a sustained effect on body representation that is comparable to that found during acute administration. We sought to ...
Checton Maria G MG Rutgers University, Piscataway, NJ, USA - - 2014
The purpose of the present study was to apply Berg and Upchurch's developmental-conceptual model toward a better understanding of how couples cope with chronic illness. Specifically, a model was hypothesized in which proximal factors (relational quality), dyadic appraisal (illness interference), and dyadic coping (partner support) influence adjustment (health condition management). ...
Nunan Robert R Schools of Biochemistry and Physiology and Pharmacology, University of Bristol, Bristol, BS8 1TD, UK. - - 2014
The efficient healing of a skin wound is something that most of us take for granted but is essential for surviving day-to-day knocks and cuts, and is absolutely relied on clinically whenever a patient receives surgical intervention. However, the management of a chronic wound - defined as a barrier defect ...
Maione Anna G AG Tufts University, Sackler School of Graduate Biomedical Sciences, Cellular, Molecular, Developmental Biology, Boston, Massachusetts, United States ; - - 2014
Diabetic foot ulcers (DFU) are a major, debilitating complication of diabetes mellitus. Unfortunately, many DFUs are refractory to existing treatments and frequently lead to amputation. The development of more effective therapies has been hampered by the lack of predictive in vitro methods to investigate the mechanisms underlying impaired healing. To ...
Wang Allen Y AY Ear Sciences Centre, School of Surgery, the University of Western Australia, Perth, Western Australia, Australia; Ear Science Institute Australia, Perth, Western Australia, Australia; Department of Otolaryngology, Head and Neck, Skull Base Surgery, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia. Electronic address: - - 2014
To review the literature on techniques for creation of chronic tympanic membrane perforations (TMP) in animal models. Establishing such models in a laboratory setting will have value if they replicate many of the properties of the human clinical condition and can thus be used for investigation of novel grafting materials ...
Du Yi-Chun - - 2014
The residual stenosis estimation of an arteriovenous shunt is a valuable for evaluating outcomes of percutaneous transluminal angioplasty (PTA) treatment and surgical revision. This paper proposes a dual-channel phonoangiography (PCG) with fractional-order features to estimate the residual of stenosis estimation of arteriovenous shunt. The auscultation technique provides a non-invasive tool ...
Corsini Chiara C Laboratory of Biological Structure Mechanics, Politecnico di Milano, Milan, - - 2014
The size of the modified Blalock-Taussig shunt and the additional presence of aortic coarctation can affect the hemodynamics of the Norwood physiology. Multiscale modeling was used to gather insight into the effects of these variables, in particular on coronary perfusion. A model was reconstructed from cardiac magnetic resonance imaging data ...
Glover M J MJ Health Economics Research Group, Brunel University, London, - - 2014
Implementation of the National Health Service abdominal aortic aneurysm (AAA) screening programme (NAAASP) for men aged 65 years began in England in 2009. An important element of the evidence base supporting its introduction was the economic modelling of the long-term cost-effectiveness of screening, which was based mainly on 4-year follow-up data ...
Dixit S G SG Department of Anatomy, All India Institute of Medical Sciences (AIIMS), Jodhpur, Rajasthan 342005, India. Electronic address: - - 2014
Various studies have been conducted on morphometric variations of infraorbital foramen to provide data to surgeons for nerve block in infraorbital region. This study aims to analyse the anatomical variations by comparing various morphometric measurements of infraorbital foramen in dry skulls of adult North Indian population. This study becomes relevant ...
Roederer Alexander A Department of Computer and Information Science, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA, - - 2014
When vasospasm is detected after aneurysmal subarachnoid hemorrhage (aSAH), it is treated with hypertensive or endovascular therapy. Current classification methods are resource-intensive, relying on specialty-trained professionals (nursing exams, transcranial dopplers, and perfusion imaging). More passively obtained variables such as cerebrospinal fluid drainage volumes, sodium, glucose, blood pressure, intracranial pressure, and ...
Raschi M M Center for CFD, George Mason University, Farifax, VA 22030, - - 2014
Simulations using the patient-specific geometry of the aneurysm may help in a better planning of the treatment and in a consequent reduction of the associated risks. We propose, evaluate, and implement a methodology for the simulation of flow diverter (FD) devices in intracranial aneurysms by using a porous medium method ...
Epstein D D Department of Applied Economics, University of Granada, Granada, - - 2014
A number of published economic evaluations of elective endovascular aneurysm repair (EVAR) versus open repair for abdominal aortic aneurysm (AAA) have come to differing conclusions about whether EVAR is cost-effective. This paper reviews the current evidence base and presents up-to-date cost-effectiveness analyses in the light of results of four randomized ...
Long Yunling - - 2014
The intracranial aneurysm (IA) size has been proved to have impacts on the hemodynamics and can be applied for the prediction of IA rupture risk. Although the relationship between aspect ratio and hemodynamic parameters was investigated using real patients and virtual models, few studies focused on longitudinal experiments of IAs ...
Chowriappa Ashirwad - - 2014
We introduce a novel vascular skeleton extraction and decomposition technique for computer-assisted diagnosis and analysis. We start by addressing the problem of vascular decomposition as a cluster optimization problem and present a methodology for weighted convex approximations. Decomposed vessel structures are then grouped using the vessel skeleton, extracted using a ...
Khan Imad S IS J.B. Marshall Laboratory for Neurovascular Therapeutics, NH, USA ; Section of Neurosurgery, Dartmouth-Hitchcock Medical Center, Lebanon, NH, - - 2014
Prototyping of cerebral vasculature models through stereolithographic methods have the ability to accurately depict the 3D structures of complicated aneurysms with high accuracy. We describe the method to manufacture such a model and review some of its uses in the context of treatment planning, research, and surgical training. We prospectively ...
Zelaya Jaime E JE Department of Biomedical Engineering, Oregon Health & Science University, Portland, Oregon, United States of - - 2014
An abdominal aortic aneurysm is a pathological dilation of the abdominal aorta, which carries a high mortality rate if ruptured. The most commonly used surrogate marker of rupture risk is the maximal transverse diameter of the aneurysm. More recent studies suggest that wall stress from models of patient-specific aneurysm geometries ...
Dhall Sandeep S Departments of Cell Biology and Neuroscience, University of California Riverside, Riverside, California, United States of America; Bioengineering Interdepartmental Graduate Program, University of California Riverside, Riverside, California, United States of - - 2014
Chronic wounds have a large impact on health, affecting ∼6.5 M people and costing ∼$25B/year in the US alone [1]. We previously discovered that a genetically modified mouse model displays impaired healing similar to problematic wounds in humans and that sometimes the wounds become chronic. Here we show how and ...
Toley Bhushan J - - 2013
We demonstrate a novel method for controlling fluid flow in paper-based devices. The method delays fluid progress through a porous channel by diverting fluid into an absorbent pad-based shunt placed into contact with the channel. Parameters to control the delay include the length and the thickness of the shunt. Using ...
Mashiko Toshihiro - - 2013
We developed a method for fabricating a 3D hollow and elastic aneurysm model useful for surgical simulation and surgical training. In this article, we explain the hollow elastic-model prototyping method and report on the effects of applying it to pre-surgical simulation and surgical training. A 3D printer using Acrylonitrile-Butadiene-Styrene (ABS) ...
Bekelis Kimon - - 2013
Object Precise delineation of individualized risks of morbidity and mortality is crucial in decision making in cerebrovascular neurosurgery. The authors attempted to create a predictive model of complications in patients undergoing cerebral aneurysm clipping (CAC). Methods The authors performed a retrospective cohort study of patients who had undergone CAC in ...
Pringle K C - - 2013
We outline the development of a reliable model of obstructive uropathy in fetal lambs highlighting our understanding of the critical time points for interventions and the variability of any such model. We identify some discoveries that may have clinical implications. The model requires 60-day-gestation fetal lambs. In lambs, glomerulogenesis is ...
He Yu-Quan YQ Department of Radiology, Second Affiliated Hospital of Nantong University , Nantong, Jiangsu , P. R. - - 2014
Abstract Objectives. A training model was designed for learners and young physicians to polish their skills in clinical practices of pinpointing and puncturing trigeminal ganglion. Methods. A head model, on both cheeks of which the deep soft tissue was replaced by stuffed organosilicone and sponge while the superficial soft tissue, ...
Chowriappa Ashirwad - - 2013
In this work we propose a Weighted Approximate Convex Decomposition (WACD) and Classification methodology for computer-aided detection (CADe) and analysis. We start by addressing the problem of vascular decomposition as a cluster optimization problem and introduce a methodology for compact geometric decomposition. Classification of decomposed vessel sections is performed using ...
Lee C J - - 2013
Fluid-structure interaction (FSI) simulations using a patient-specific geometry are carried out to investigate the influence the length of elastic parent artery and the position of constraints in the solid domain on the accuracy of patient-specific FSI simulations. Three models are tested: Long, Moderate, and Short, based on the length of ...
Haskett Darren - - 2013
AAA is a complex disease that leads to a localized dilation of the infrarenal aorta that develops over years. Longitudinal information in humans has been difficult to obtain for this disease, therefore mouse models have become increasingly used to study the development of AAAs. The objective of this study was ...
Weichert F - - 2013
In this paper an approach for developing a temporal domain ontology for biomedical simulations is introduced. The ideas are presented in the context of simulations of blood flow in aneurysms using the Lattice Boltzmann Method. The advantages in using ontologies are manyfold: On the one hand, ontologies having been proven ...
Lu Jia J Department of Mechanical and Industrial Engineering, The University of Iowa, Iowa City, IA 52242, USA. - - 2013
Predicting pressure induced wall stress in intracranial aneurysms continues to be of interest for aneurysm safety assessment. In quasi-static analysis, there are two distinct approaches that one may take, the forward approach and the inverse approach. The inverse approach starts from a deformed configuration and thus is naturally suited to ...
Sen Yuka - - 2013
Though providing vital means for the visualization, diagnosis, and quantification of decision-making processes for the treatment of vascular pathologies, vascular segmentation remains a process that continues to be marred by numerous challenges. In this study, we validate eight aneurysms via the use of two existing segmentation methods; the Region Growing ...
Kono Kenichi - - 2013
Silicone models of cerebral aneurysms are used for evaluation of devices, training, or hemodynamic studies. We report preoperative simulations of endovascular treatment for a case with an unruptured wide-neck aneurysm of the anterior communicating artery using a patient-specific silicone model. Using a rapid prototyping system, we created a silicone model ...
Karim Sulafa - - 2013
The majority of radiological reports are lacking a standard structure. Even within a specialized area of radiology, each report has its individual structure with regards to details and order, often containing too much of non-relevant information the referring physician is not interested in. For gathering relevant clinical key parameters in ...
Kowalchyk Katherine - - 2013
A comparison of the Hatch-Waxman Act for approval of small-molecule pharmaceuticals with the Biological Price Competition and Innovation Act for approval of biosimilars provides insight into the market entry and patent litigation for biosimilars. Key differences between the two statutes include a longer period of statutory exclusivity for biosimilars, no ...
Neidert Marian Christoph - - 2013
To assess the potential meteorological influence on the incidence of aneurysmal subarachnoid hemorrhage (SAH). Previous studies used inhomogeneous patient groups, insufficient study periods or inappropriate statistics. We analyzed 511 SAH admissions between 2004 and 2012 for which aneurysmal rupture occurred within the Zurich region. The hourly meteorological parameters considered are: ...
Park Hyun-Seok - - 2012
Whereas a vast amount of new information on bioinformatics is made available to the public through patents, only a small set of patents are cited in academic papers. A detailed analysis of registered bioinformatics patents, using the existing patent search system, can provide valuable information links between science and technology. ...
Low K K Swansea Biomedical Computing Lab, College of Engineering, Swansea University, Swansea SA2 8PP, - - 2012
In this study, an improved and robust one-dimensional human arterial network model is presented. The one-dimensional blood flow equations are solved using the Taylor-locally conservative Galerkin finite element method. The model improvements are carried out by adopting parts of the physical models from different authors to establish an accurate baseline ...
Hodis Simona - - 2012
Computational fluid dynamics (CFD) has become a cutting-edge tool for investigating hemodynamic dysfunctions in the body. It has the potential to help physicians quantify in more detail the phenomena difficult to capture with in vivo imaging techniques. CFD simulations in anatomically realistic geometries pose challenges in generating accurate solutions due ...
Doyle Barry J BJ Centre for Applied Biomedical Engineering Research-CABER, Department of Mechanical, Aeronautical and Biomedical Engineering, and Materials and Surface Science Institute, University of Limerick, Ireland. - - 2013
Patient-specific modelling of abdominal aortic aneurysm has been shown to have clinical potential. This paper examines a large ruptured abdominal aortic aneurysm where the tissue from the diseased wall and the intraluminal thrombus was excised during open surgical repair and experimentally characterised. The mechanical data were used to develop material ...
Karuppanan P - - 2012
The authors acknowledge certain errors in their recently published paper titled "PI and fuzzy logic controllers for shunt active power filter--A report.The ambiguity in band width calculation of adaptive hysteresis controller and control aspects of dc-link voltage issues are addressed. The shunt APF system is validated through extensive simulation and ...
Bogaert Peter - - 2012
This article sheds light on the relationship, or rather, absence of a relationship, between patent rights and regulatory approval procedures in the EU. The principle of 'patent linkage' has long been recognized and applied by regulatory authorities in the USA. The European Commission, however, opposes the idea of linking patent ...
van der Fels-Klerx H J - - 2012
Climate change is expected to affect food and feed safety, including the occurrence of natural toxins in primary crop and seafood production; however, to date, quantitative estimates are scarce. This study aimed to estimate the impact of climate change effects on mycotoxin contamination of cereal grains cultivated in the terrestrial ...
Pienaar Ilse S - - 2012
Animal models that make use of chemical toxins to adversely affect the nigrostriatal dopaminergic pathway of rodents and primates have contributed significantly towards the development of symptomatic therapies for Parkinson's disease (PD) patients. Although their use in developing neuro-therapeutic and -regenerative compounds remains to be ascertained, toxin-based mammalian and a ...
Kashyap Sudhanshu - - 2012
We report the computational structural simulation of the Cry1Ab19 toxin molecule from B. thuringiensis BtX-2 based on the structure of Cry1Aa1 deduced by x-ray diffraction. Validation results showed that 93.5% of modeled residues are folded in a favorable orientation with a total energy Z-score of -8.32, and the constructed model ...
Sesardic Thea T Division of Bacteriology, National Institute for Biological Standards and Control, South Mimms, Potters Bar, Hertfordshire EN6 3QG, United Kingdom. - - 2012
Bioassays play central role in evaluation of biological products and those derived from bacterial toxins often rely exclusively on in vivo models for assurance of safety and potency. This chapter reviews existing regulatory approved methods designed to provide information on potency and safety of complex biological medicines with an insight ...
Schenzel Judith - - 2012
Although natural toxins such as mycotoxins or phytoestrogens are widely studied and were recently identified as micropollutants in the environment, many of their environmentally relevant physico-chemical properties have not yet been determined. Here, the sorption affinity to Pahokee peat, a model sorbent for soil organic matter, was investigated for 29 ...
Schipper Joel D - - 2012
OBJECTIVE: Every year, toxic exposures kill 1200 Americans. To aid in the timely diagnosis and treatment of such exposures, this research investigates the feasibility of a knowledge-based system capable of generating differential diagnoses for human exposures involving unknown toxins. METHODS: Data mining techniques automatically extract prior probabilities and likelihood ratios ...
Cataudella Ilaria - - 2012
Many toxin-antitoxin (TA) loci are known to strongly repress their own transcription. This auto-inhibition is often called 'conditional cooperativity' as it relies on cooperative binding of TA complexes to operator DNA that occurs only when toxins are in a proper stoichiometric relationship with antitoxins. There has recently been an explosion ...
Weedermann Marion - - 2012
Anaerobic digestion has been modeled as a two-stage process using coupled chemostat models with non-monotone growth functions, [9]. This study incorporates the effects of an external toxin. After reducing the model to a 3-dimensional system, global stability of boundary and interior equilibria is proved using differential inequalities and comparisons to ...
Zhang Bo - - 2012
Linear mixed-effects models involve fixed effects, random effects and covariance structure, which require model selection to simplify a model and to enhance its interpretability and predictability. In this article, we develop, in the context of linear mixed-effects models, the generalized degrees of freedom and an adaptive model selection procedure defined ...
Best Emma L EL Leeds Teaching Hospitals NHS Trust, Microbiology Department, Old Medical School, Leeds General Infirmary, Leeds, UK. - - 2012
Models of Clostridium difficile infection (C. difficile) have been used extensively for Clostridium difficile (C. difficile) research. The hamster model of C. difficile infection has been most extensively employed for the study of C. difficile and this has been used in many different areas of research, including the induction of ...
Mahmoudi M - - 2012
The purpose of this systematic review was to review the cost-effectiveness of first-line non-nicotine therapies (varenicline and bupropion SR) for smoking cessation, identify differences in the models used and their conclusions of cost-effectiveness, and to determine which variables, if any, impact conclusions of cost-effectiveness. A systematic literature search was conducted ...
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