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Roederer Alexander A Department of Computer and Information Science, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA, - - 2014
When vasospasm is detected after aneurysmal subarachnoid hemorrhage (aSAH), it is treated with hypertensive or endovascular therapy. Current classification methods are resource-intensive, relying on specialty-trained professionals (nursing exams, transcranial dopplers, and perfusion imaging). More passively obtained variables such as cerebrospinal fluid drainage volumes, sodium, glucose, blood pressure, intracranial pressure, and ...
Raschi M M Center for CFD, George Mason University, Farifax, VA 22030, - - 2014
Simulations using the patient-specific geometry of the aneurysm may help in a better planning of the treatment and in a consequent reduction of the associated risks. We propose, evaluate, and implement a methodology for the simulation of flow diverter (FD) devices in intracranial aneurysms by using a porous medium method ...
Epstein D D Department of Applied Economics, University of Granada, Granada, - - 2014
A number of published economic evaluations of elective endovascular aneurysm repair (EVAR) versus open repair for abdominal aortic aneurysm (AAA) have come to differing conclusions about whether EVAR is cost-effective. This paper reviews the current evidence base and presents up-to-date cost-effectiveness analyses in the light of results of four randomized ...
Long Yunling - - 2014
The intracranial aneurysm (IA) size has been proved to have impacts on the hemodynamics and can be applied for the prediction of IA rupture risk. Although the relationship between aspect ratio and hemodynamic parameters was investigated using real patients and virtual models, few studies focused on longitudinal experiments of IAs ...
Chowriappa Ashirwad - - 2014
We introduce a novel vascular skeleton extraction and decomposition technique for computer-assisted diagnosis and analysis. We start by addressing the problem of vascular decomposition as a cluster optimization problem and present a methodology for weighted convex approximations. Decomposed vessel structures are then grouped using the vessel skeleton, extracted using a ...
Khan Imad S IS J.B. Marshall Laboratory for Neurovascular Therapeutics, NH, USA ; Section of Neurosurgery, Dartmouth-Hitchcock Medical Center, Lebanon, NH, - - 2014
Prototyping of cerebral vasculature models through stereolithographic methods have the ability to accurately depict the 3D structures of complicated aneurysms with high accuracy. We describe the method to manufacture such a model and review some of its uses in the context of treatment planning, research, and surgical training. We prospectively ...
Toley Bhushan J - - 2013
We demonstrate a novel method for controlling fluid flow in paper-based devices. The method delays fluid progress through a porous channel by diverting fluid into an absorbent pad-based shunt placed into contact with the channel. Parameters to control the delay include the length and the thickness of the shunt. Using ...
Mashiko Toshihiro - - 2013
We developed a method for fabricating a 3D hollow and elastic aneurysm model useful for surgical simulation and surgical training. In this article, we explain the hollow elastic-model prototyping method and report on the effects of applying it to pre-surgical simulation and surgical training. A 3D printer using Acrylonitrile-Butadiene-Styrene (ABS) ...
Bekelis Kimon - - 2013
Object Precise delineation of individualized risks of morbidity and mortality is crucial in decision making in cerebrovascular neurosurgery. The authors attempted to create a predictive model of complications in patients undergoing cerebral aneurysm clipping (CAC). Methods The authors performed a retrospective cohort study of patients who had undergone CAC in ...
Pringle K C - - 2013
We outline the development of a reliable model of obstructive uropathy in fetal lambs highlighting our understanding of the critical time points for interventions and the variability of any such model. We identify some discoveries that may have clinical implications. The model requires 60-day-gestation fetal lambs. In lambs, glomerulogenesis is ...
He Yu-Quan YQ Department of Radiology, Second Affiliated Hospital of Nantong University , Nantong, Jiangsu , P. R. - - 2014
Abstract Objectives. A training model was designed for learners and young physicians to polish their skills in clinical practices of pinpointing and puncturing trigeminal ganglion. Methods. A head model, on both cheeks of which the deep soft tissue was replaced by stuffed organosilicone and sponge while the superficial soft tissue, ...
Chowriappa Ashirwad - - 2013
In this work we propose a Weighted Approximate Convex Decomposition (WACD) and Classification methodology for computer-aided detection (CADe) and analysis. We start by addressing the problem of vascular decomposition as a cluster optimization problem and introduce a methodology for compact geometric decomposition. Classification of decomposed vessel sections is performed using ...
Lee C J - - 2013
Fluid-structure interaction (FSI) simulations using a patient-specific geometry are carried out to investigate the influence the length of elastic parent artery and the position of constraints in the solid domain on the accuracy of patient-specific FSI simulations. Three models are tested: Long, Moderate, and Short, based on the length of ...
Haskett Darren - - 2013
AAA is a complex disease that leads to a localized dilation of the infrarenal aorta that develops over years. Longitudinal information in humans has been difficult to obtain for this disease, therefore mouse models have become increasingly used to study the development of AAAs. The objective of this study was ...
Weichert F - - 2013
In this paper an approach for developing a temporal domain ontology for biomedical simulations is introduced. The ideas are presented in the context of simulations of blood flow in aneurysms using the Lattice Boltzmann Method. The advantages in using ontologies are manyfold: On the one hand, ontologies having been proven ...
Lu Jia - - 2013
Predicting pressure induced wall stress in intracranial aneurysms continues to be of interest for aneurysm safety assessment. In quasi-static analysis, there are two distinct approaches that one may take, the forward approach and the inverse approach. The inverse approach starts from a deformed configuration and thus is naturally suited to ...
Sen Yuka - - 2013
Though providing vital means for the visualization, diagnosis, and quantification of decision-making processes for the treatment of vascular pathologies, vascular segmentation remains a process that continues to be marred by numerous challenges. In this study, we validate eight aneurysms via the use of two existing segmentation methods; the Region Growing ...
Kono Kenichi - - 2013
Silicone models of cerebral aneurysms are used for evaluation of devices, training, or hemodynamic studies. We report preoperative simulations of endovascular treatment for a case with an unruptured wide-neck aneurysm of the anterior communicating artery using a patient-specific silicone model. Using a rapid prototyping system, we created a silicone model ...
Karim Sulafa - - 2013
The majority of radiological reports are lacking a standard structure. Even within a specialized area of radiology, each report has its individual structure with regards to details and order, often containing too much of non-relevant information the referring physician is not interested in. For gathering relevant clinical key parameters in ...
Kowalchyk Katherine - - 2013
A comparison of the Hatch-Waxman Act for approval of small-molecule pharmaceuticals with the Biological Price Competition and Innovation Act for approval of biosimilars provides insight into the market entry and patent litigation for biosimilars. Key differences between the two statutes include a longer period of statutory exclusivity for biosimilars, no ...
Neidert Marian Christoph - - 2013
To assess the potential meteorological influence on the incidence of aneurysmal subarachnoid hemorrhage (SAH). Previous studies used inhomogeneous patient groups, insufficient study periods or inappropriate statistics. We analyzed 511 SAH admissions between 2004 and 2012 for which aneurysmal rupture occurred within the Zurich region. The hourly meteorological parameters considered are: ...
Low K - - 2012
In this study, an improved and robust one-dimensional human arterial network model is presented. The one-dimensional blood flow equations are solved using the Taylor-locally conservative Galerkin finite element method. The model improvements are carried out by adopting parts of the physical models from different authors to establish an accurate baseline ...
Park Hyun-Seok - - 2012
Whereas a vast amount of new information on bioinformatics is made available to the public through patents, only a small set of patents are cited in academic papers. A detailed analysis of registered bioinformatics patents, using the existing patent search system, can provide valuable information links between science and technology. ...
Hodis Simona - - 2012
Computational fluid dynamics (CFD) has become a cutting-edge tool for investigating hemodynamic dysfunctions in the body. It has the potential to help physicians quantify in more detail the phenomena difficult to capture with in vivo imaging techniques. CFD simulations in anatomically realistic geometries pose challenges in generating accurate solutions due ...
Doyle Barry J - - 2012
Patient-specific modelling of abdominal aortic aneurysm has been shown to have clinical potential. This paper examines a large ruptured abdominal aortic aneurysm where the tissue from the diseased wall and the intraluminal thrombus was excised during open surgical repair and experimentally characterised. The mechanical data were used to develop material ...
Karuppanan P - - 2012
The authors acknowledge certain errors in their recently published paper titled "PI and fuzzy logic controllers for shunt active power filter--A report.The ambiguity in band width calculation of adaptive hysteresis controller and control aspects of dc-link voltage issues are addressed. The shunt APF system is validated through extensive simulation and ...
Bogaert Peter - - 2012
This article sheds light on the relationship, or rather, absence of a relationship, between patent rights and regulatory approval procedures in the EU. The principle of 'patent linkage' has long been recognized and applied by regulatory authorities in the USA. The European Commission, however, opposes the idea of linking patent ...
van der Fels-Klerx H J - - 2012
Climate change is expected to affect food and feed safety, including the occurrence of natural toxins in primary crop and seafood production; however, to date, quantitative estimates are scarce. This study aimed to estimate the impact of climate change effects on mycotoxin contamination of cereal grains cultivated in the terrestrial ...
Pienaar Ilse S - - 2012
Animal models that make use of chemical toxins to adversely affect the nigrostriatal dopaminergic pathway of rodents and primates have contributed significantly towards the development of symptomatic therapies for Parkinson's disease (PD) patients. Although their use in developing neuro-therapeutic and -regenerative compounds remains to be ascertained, toxin-based mammalian and a ...
Kashyap Sudhanshu - - 2012
We report the computational structural simulation of the Cry1Ab19 toxin molecule from B. thuringiensis BtX-2 based on the structure of Cry1Aa1 deduced by x-ray diffraction. Validation results showed that 93.5% of modeled residues are folded in a favorable orientation with a total energy Z-score of -8.32, and the constructed model ...
Sesardic Thea - - 2012
Bioassays play central role in evaluation of biological products and those derived from bacterial toxins often rely exclusively on in vivo models for assurance of safety and potency. This chapter reviews existing regulatory approved methods designed to provide information on potency and safety of complex biological medicines with an insight ...
Schenzel Judith - - 2012
Although natural toxins such as mycotoxins or phytoestrogens are widely studied and were recently identified as micropollutants in the environment, many of their environmentally relevant physico-chemical properties have not yet been determined. Here, the sorption affinity to Pahokee peat, a model sorbent for soil organic matter, was investigated for 29 ...
Schipper Joel D - - 2012
OBJECTIVE: Every year, toxic exposures kill 1200 Americans. To aid in the timely diagnosis and treatment of such exposures, this research investigates the feasibility of a knowledge-based system capable of generating differential diagnoses for human exposures involving unknown toxins. METHODS: Data mining techniques automatically extract prior probabilities and likelihood ratios ...
Cataudella Ilaria - - 2012
Many toxin-antitoxin (TA) loci are known to strongly repress their own transcription. This auto-inhibition is often called 'conditional cooperativity' as it relies on cooperative binding of TA complexes to operator DNA that occurs only when toxins are in a proper stoichiometric relationship with antitoxins. There has recently been an explosion ...
Weedermann Marion - - 2012
Anaerobic digestion has been modeled as a two-stage process using coupled chemostat models with non-monotone growth functions, [9]. This study incorporates the effects of an external toxin. After reducing the model to a 3-dimensional system, global stability of boundary and interior equilibria is proved using differential inequalities and comparisons to ...
Zhang Bo - - 2012
Linear mixed-effects models involve fixed effects, random effects and covariance structure, which require model selection to simplify a model and to enhance its interpretability and predictability. In this article, we develop, in the context of linear mixed-effects models, the generalized degrees of freedom and an adaptive model selection procedure defined ...
Best Emma L - - 2012
Models of Clostridium difficile infection (C. difficile) have been used extensively for Clostridium difficile (C. difficile) research. The hamster model of C. difficile infection has been most extensively employed for the study of C. difficile and this has been used in many different areas of research, including the induction of ...
Mahmoudi M - - 2012
The purpose of this systematic review was to review the cost-effectiveness of first-line non-nicotine therapies (varenicline and bupropion SR) for smoking cessation, identify differences in the models used and their conclusions of cost-effectiveness, and to determine which variables, if any, impact conclusions of cost-effectiveness. A systematic literature search was conducted ...
Chilton Caroline H - - 2012
OBJECTIVES: Co-amoxiclav is widely prescribed in hospitals. Although reports have suggested it may be linked to onset of Clostridium difficile infection (CDI), data on the risk of CDI associated with specific antibiotics is difficult to obtain, due to confounding clinical factors. We have examined the propensity of co-amoxiclav to induce ...
te Velde Egbert - - 2012
Postponement of childbearing since the 1970s has led to an increase in permanent involuntarily childlessness. We will address the magnitude of this trend, the effect of IVF/ICSI and the effect on total fertility rate (TFR an often used demographic measure for the level of fertility) in six EU countries. Using ...
Li Zhengguang - - 2012
Camptothecin (CPT) exhibits very strong antitumor effects by inhibiting the activity of DNA topoisomerase I, but its application is greatly limited due to its low solubility and the instability of the active lactone form. To overcome these shortcomings, in the present study, we prepared novel camptothecin nanocolloids based on N,N,N-trimethyl ...
Blader Steven L - - 2012
Few empirical efforts have been devoted to differentiating status and power, and thus significant questions remain about differences in how status and power impact social encounters. We conducted 5 studies to address this gap. In particular, these studies tested the prediction that status and power would have opposing effects on ...
Trocóniz Iñaki F - - 2012
Flibanserin is being developed for treating hypoactive sexual desire disorder in women; the main side effect is sedation. The analysis objective was to relate flibanserin plasma concentrations with acute sedative effects using a population pharmacokinetic/pharmacodynamic (PK/PD) model. The population model was developed with NONMEM based on data from 24 healthy ...
Hill William G - - 2012
Analyses of effects of mutants on many traits have enabled estimates to be obtained of the magnitude of pleiotropy, and in reviews of such data others have concluded that the degree of pleiotropy is highly restricted, with implications on the evolvability of complex organisms. We show that these conclusions are ...
Shen Yunhe - - 2012
Here we introduce a new virtual reality (VR) based simulation system for training the urological procedure of intra-detrusor botulinum toxin (Botox®) injections into the bladder. 6 cases with different bladder anatomy and 3 subtasks are included in the curriculum; this design is guided by several expert urologists according to clinical ...
Kohtz Amy S - - 2012
Developments in behavioral assessment, autonomic and/or baseline reactivity, psychopharmacology, and genetics, have contributed significantly to the assessment of performance-enhancing drugs in animal models. Particular classes of steroid hormones: androgenic steroids are of interest. Anecdotally, the performance enhancing effects of androgens are attributed to anabolic events. However, there is a discrepancy ...
Yang Zhou - - 2012
The occurrence of Microcystis blooms is a worldwide concern that has caused numerous adverse effects on water quality and lake ecology. Elevated ammonia and microcystin concentrations co-occur during the degradation of Microcystis blooms and are toxic to aquatic organisms; we studied the relative and combined effects of these on the ...
Luque Fernandez Miguel A - - 2012
In highly populated African urban areas where access to clean water is a challenge, water source contamination is one of the most cited risk factors in a cholera epidemic. During the rainy season, where there is either no sewage disposal or working sewer system, runoff of rains follows the slopes ...
Biasetti Jacopo - - 2012
Abdominal Aortic Aneurysms (AAAs) are frequently characterized by the presence of an Intra-Luminal Thrombus (ILT) known to influence their evolution biochemically and biomechanically. The ILT progression mechanism is still unclear and little is known regarding the impact of the chemical species transported by blood flow on this mechanism. Chemical agonists ...
Wilson Richard D - - 2011
OBJECTIVE: To provide a cost-effectiveness analysis of dysphagia screening in the acute poststroke period with use of a videofluoroscopic swallowing study, a clinical bedside swallowing evaluation, or a combined approach. DESIGN: Decision-analysis model. METHODS: A decision-analysis model was used with information derived from multiple data sources, including meta-analyses and other ...
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