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Li Jia J a Department of Mathematical Sciences , University of Alabama in Huntsville , Huntsville , AL 35899 , - - 2015
To prevent the transmissions of malaria, dengue fever, or other mosquito-borne diseases, one effective weapon is the sterile insect technique in which sterile mosquitoes are released to reduce or eradicate the wild mosquito population. To study the impact of the sterile insect technique on disease transmission, we formulate discrete-time mathematical ...
- - 2015
Coarse-grained models with short-ranged and anisotropic interactions have recently gained significant attention from the soft matter and biophysics community. The models are being increasingly used for the investigation of biological macromolecules, self-assembly processes, and for the synthesis of new materials. On page 1 (DOI: 10.1002/jcc.23763), Lorenzo Rovigatti, Petr Šulc, István ...
Lawrenson Tom T Department of Crop Genetics, John Innes Centre, Norwich Research Park, Norwich, NR4 7UH, - - 2015
Within this chapter we outline an A. tumefaciens-mediated transformation method for B. rapa using 4-day-old cotyledonary explants and the genotype R-o-18. Transformation efficiencies are typically achieved in the region of 1 % (based on 2 PCR-positive independent shoots from 200 inoculated explants). This system has been developed to work with ...
Song Jonathan W JW Edwin L. Steele Laboratory for Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Building 149, 13th Street, Charlestown, MA, 02129, - - 2015
Microfluidic systems have emerged as an important technology for modeling cellular microenvironments in vitro. These systems enable unprecedented levels of control of chemical gradients, fluid flow, and localized 3-D extracellular matrices (ECM), all of which can be integrated to provide a physiologically relevant context for studying complex cellular processes such ...
Mochel Jonathan P JP Department of Pharmacology, Leiden-Academic Centre for Drug Research, 2300, Leiden, The Netherlands, - - 2014
The objective of this research was to provide a comprehensive description of the effect of benazepril on the dynamics of the renin-angiotensin aldosterone system (RAAS) in dogs. Blood specimens for renin activity (RA), angiotensin II (AII), and aldosterone (ALD) quantitation in plasma were drawn from 12 healthy adult beagle dogs ...
Pillai Girinath G - - 2014
Structure-activity relations in a data set of HPV6-E1 helicase ATPase inhibitors were investigated based on two different sets of descriptors. Statistically significant four parameter Quantitative Structure-Activity Relationships (QSAR) models were constructed and validated in both cases (R2=0.849; R2cv=0.811; F=52.20; s2=0.25; N=42). A Fragment based QSAR (FQSAR) approach was applied for ...
Giedroyć-Piasecka Wiktoria - - 2014
Fatty acid amide hydrolase (FAAH) is an enzyme responsible for the deactivating hydrolysis of fatty acid ethanolamide neuromodulators. FAAH inhibitors gain considerable interest due to their possible application in the treatment of anxiety, inflammation, and pain. In the context of inhibitor design, the availability of reliable computational tools for binding ...
Yi Qianying - - 2014
Nicotinamide phosphoribosyltransferase (NAMPT), an enzyme taking part in main NAD biosynthetic pathway, is an attractive target for anticancer therapy. The purpose of our study is to find novel NAMPT inhibitors based on in silico drug discovery means including the generation of 3D-QSAR models, and virtual screening techniques. Firstly, ten pharmacophore ...
Zhang Qi Q Pharmaceutical Analytical & Solid-State Chemistry Research Center, Shanghai Institute of Materia Medica , Chinese Academy of Sciences, Shanghai , - - 2014
Abstract Thermodynamic properties of polymorphic forms I and II of Agomelatine were investigated and the bimorphism was determined to be monotropically related. The phase transition kinetics from metastable form I to thermodynamically stable form II was studied and a quantification method was developed based on X-ray powder diffraction technique. Various ...
Greenberg Jay - - 2014
Models of the psychoanalytic situation can usefully be thought of as fictions. Viewed this way, the models can be understood as narrative structures that shape what we are able to see and how we are able to think about what happens between us and our analysands. Theories of therapeutic action ...
Devaraju N N Divecha Center for Climate Change & Center for Atmospheric and Oceanic Sciences Indian Institute of Science, Bangalore -560012, - - 2014
Land-use changes since the start of the industrial era account for nearly one-third of the cumulative anthropogenic CO2 emissions. In addition to the greenhouse effect of CO2 emissions, changes in land use also affect climate via changes in surface physical properties such as albedo, evapotranspiration, and roughness length. Recent modeling ...
Wang Guangwei G School of Metallurgical and Ecological Engineering, University of Science and Technology Beijing, Beijing 100083, - - 2014
The CO2 gasification properties and kinetics of three biomass chars (WS-char, RL-char and PS-char) and anthracite char (AC-char) were investigated by thermogravimetric analysis method. Three nth-order representative gas-solid reaction models, random pore model (RPM), volume reaction model (VM) and unreacted core model (URCM) were employed to describe the reactive behavior ...
Saab Rim R American University of Beirut, - - 2014
We examined predictors of collective action among bystander group members in solidarity with a disadvantaged group by extending the dual pathway model of collective action, which proposes one efficacy-based and one emotion-based path to collective action (Van Zomeren, Spears, Fischer, & Leach, 2004). Based on two proposed functions of social ...
Pataky Todd C TC Department of Bioengineering, Shinshu University, Japan. Electronic address: - - 2014
Kinematic and force trajectories are often normalized in time, with mean and variance summary statistic trajectories reported. It has been shown elsewhere, for simple one-factor experiments, that statistical testing can be conducted directly on those summary statistic trajectories using Random Field Theory (RFT). This technical note describes how RFT extends ...
Peach D D Department of Mathematics, Bates College, Lewiston, ME 04240, - - 2014
Though portable accelerometers are ubiquitous in physiology and public health studies, their accuracy as objective measures of physical activity is still being examined. This paper enumerates and analyzes the various biases of the widely used ActiLife(®) software in reporting activity counts from ActiGraph(®) accelerometers. In particular, we focus on the ...
Vulic Katarina K Department of Chemistry, University of Toronto, Toronto, Ontario M5S 3E1, Canada; The Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, - - 2014
Affinity-based controlled release modulates the delivery of protein or small molecule therapeutics through transient dissociation/association. To understand which parameters can be used to tune release, we used a mathematical model based on simple binding kinetics. A comprehensive asymptotic analysis revealed three characteristic regimes for therapeutic release from affinity-based systems. These ...
Lievens Filip - - 2014
In assessment centers (ACs), research on eliciting candidate behavior and evaluating candidate behavior have largely followed independent paths. This study integrates trait activation and trait rating models to posit hypotheses about the effects of behavior elicitation via situational cues on key assessor observation and rating variables. To test the hypotheses, ...
Lu Wenhua W Department of Health & Kinesiology, Texas A&M University, College Station, TX, USA. - - 2014
To test a modified integrative model (IM) in explaining parents' intention toward active commuting to school (ACS) and children's ACS. Parents of fourth graders (N = 857) completed a survey assessing factors associated with ACS. A modified IM was developed and tested using structural equation modeling. The IM demonstrated good ...
Kumar Pritesh P a Department of Pharmacology and Toxicology , University of Louisville , Louisville , KY , - - 2014
The categorical structure-activity relationship (cat-SAR) expert system has been successfully used in the analysis of chemical compounds that cause toxicity. Herein we describe the use of this fragment-based approach to model ligands for the G protein-coupled receptor 119 (GPR119). Using compounds that are known GPR119 agonists and compounds that we ...
Fu Chih-Yuan CY Department of Trauma and Emergency Surgery, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan, - - 2014
Several reports have indicated the benefits of the acute care surgery (ACS) model in surgical outcomes. We tried to delineate the impact of the ACS model on surgical efficiency and quality. Before the ACS model was implemented, abdominal surgical emergencies were evaluated by an on-call nontrauma general surgeon (pre-ACS model). ...
Abouei Ardakan Mostafa M Department of Industrial and Systems Engineering, Isfahan University of Technology, 84156-83111 Isfahan, Iran. Electronic address: - - 2014
Redundancy Allocation Problem (RAP) is a challenging subject which has attracted the attention of many authors. Generally, in the RAP there are two strategies for using the redundant components: active and standby. In this paper a new redundancy strategy, called mixed redundancy, is introduced and considered in a multi-objective optimization ...
Andersson C David CD Department of Chemistry, Umeå University, 90187, Umeå, - - 2014
Scientific disciplines such as medicinal- and environmental chemistry, pharmacology, and toxicology deal with the questions related to the effects small organic compounds exhort on biological targets and the compounds' physicochemical properties responsible for these effects. A common strategy in this endeavor is to establish structure-activity relationships (SARs). The aim of ...
Chekkara Rajasekhar - - 2014
Polo-like kinase 1 (Plk1) is a decisive enzyme with its multifunctional activity in cell cycle progression especially mitosis. The over expression of Plk1 in broad spectrum of cancer types turn into a promising therapeutic target against cancer. In the present study, several ligand based pharmacophore models and atom based 3D-QSAR ...
Weirick Tyler - - 2014
Laccases (E.C. 1.10.3.2) are multi-copper oxidases that have gained importance in many industries such as biofuels, pulp production, textile dye bleaching, bioremediation, and food production. Their usefulness stems from the ability to act on a diverse range of phenolic compounds such as o-/p-quinols, aminophenols, polyphenols, polyamines, aryl diamines, and aromatic ...
Zhao Huaiyong H Department of Cognitive, Linguistic and Psychological Sciences, Brown - - 2014
Two general approaches to the visual control of action have emerged in last few decades, known as the on-line and model-based approaches. The key difference between them is whether action is controlled by current visual information or on the basis of an internal world model. In this paper, we evaluate ...
McGuinn Tammy L TL Tammy L. McGuinn works as an adult gerontology nurse practitioner at Highland Family Practice in Lancaster, PA and is a clinical adjunct professor at York College of Pennsylvania, York, PA. Susan Scherr is a visiting assistant professor of nursing at York College of Pennsylvania, York, - - 2014
Warfarin is the most commonly prescribed oral anticoagulant. The management of warfarin is challenging, and current guidelines fail to include a model to assist practitioners in optimizing therapeutic dosing. The traditional model and the anticoagulation clinic (AC) model of warfarin management were compared and results found the AC model optimum.
Suthar Sharad Kumar SK Department of Pharmacy, Jaypee University of Information Technology, Waknaghat, 173234, - - 2014
NSAIDs are among the most widely prescribed medications across the world, but the gastrointestinal (GI) toxicity still remains the biggest problem and the challenge for current NSAIDs-based therapeutics. The development of selective COX-2 inhibitors was driven by the assumption that selective inhibition of COX-2 would reduce the GI side effects. ...
Worek Franz F Bundeswehr Institute of Pharmacology and Toxicology, Munich, Germany. Electronic address: - - 2014
The well-established dynamic in vitro model for the real-time determination of acetylcholinesterase activity was modified for use of human butyrylcholinesterase (BChE) activity. Human plasma as BChE source was layered on a syringe filter and the enzyme reactor was continuously perfused with phosphate buffer, butyrylthiocholine and Ellman's reagent at pH 7.4 ...
Pisani Leonardo L Dipartimento di Farmacia - Scienze del Farmaco, Università degli Studi di Bari "Aldo Moro", Via E. Orabona, 4, I-70125 Bari, - - 2014
Inhibition data on rat monoamine oxidase B isoform of a large number of 7-metahalobenzyloxy-2H-chromen-2-one derivatives (67 compounds) carrying at position 4 a variety of substituents differing in steric, electrostatic, lipophilic and H-bonding properties, were modeled by Gaussian field-based 3D-QSAR and docking simulations carried out on rat MAO-B homology model. The ...
Chapleau Richard R - - 2014
One of the leading causes of death and illness within the agriculture industry is through unintentionally ingesting or inhaling organophosphate pesticides. OP intoxication directly inhibits acetylcholinesterase, resulting in an excitatory signaling cascade leading to fasciculation, loss of control of bodily fluids, and seizures. Our model was developed using a discrete, ...
Afzal Obaid O Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Hamdard University, New Delhi, - - 2014
The purpose of this study is to build up the 3D pharmacophore of Monoacylglycerol lipase (MAGL) inhibitor and to provide the basis to design the novel and potent MAGL inhibitors. A 3D-QSAR study on benztriazol-1-yl carboxamide derivatives as monoacylglycerol lipase (MAGL) inhibitors was successfully performed by means of pharmacophore mapping ...
Fortin Annie-Pier AP Université Laval, Département de Kinésiologie, Faculté de Médecine, 2300, rue de la Terrasse, Québec, QC, Canada G1V 0A6. Electronic address: - - 2014
Anticipatory postural adjustments (APAs) of gait initiation (GI) permit first step execution. APAs are characterized by a structured pattern of soleus (SOL) inhibition followed by tibialis anterior (TA) activation. This pattern shows variability among young adults where SOL is not always inhibited before TA activation. Initial posture preceding GI could ...
Chailleux Anaïs A French National Institute for Agricultural Reseach (INRA), UMR1355-ISA, 400 route des chappes, 06903, Sophia-Antipolis, France; InVivo AgroSolutions, 83 Avenue de la grande Armée, 75582, Paris, France; CIRAD, UPR HortSys, F-34398, Montpellier, - - 2014
Understanding how arthropod pests and their natural enemies interact in complex agro-ecosystems is essential for pest management programs. Theory predicts that prey sharing a predator, such as a biological control agent, can indirectly reduce each other's density at equilibrium (apparent competition). From this premise, we (i) discuss the complexity of ...
Liang Geng G School of Control and Computer Engineering, North China Electric Power University, Beijing 102206, - - 2014
In this paper, improving control performance of a networked control system by reducing DTD in a different perspective was investigated. Two different network architectures for system implementation were presented. Analysis and improvement dealing with DTD for the experimental control system were expounded. Effects of control scheme configuration on DTD in ...
Kannan Srinivasaraghavan - - 2014
Schistosomiasis, caused by S. mansoni, is a tropical disease that affects over 200 million people worldwide. A novel approach for targeting eukaryotic parasites is to tackle their dynamic epigenetic machinery that is necessary for the extensive phenotypic changes during their life cycle. We recently identified S. mansoni histone deacetylase 8 ...
Wong Kai Y - - 2014
BackgroundThe evaluation of the clinical effects of Tacrine has shown efficacy in delaying the deterioration of the symptoms of Alzheimer¿s disease, while confirming the adverse events consisting mainly in the elevated liver transaminase levels. The study of tacrine analogs presents a continuous interest, and for this reason we establish Quantitative ...
Li Qiao Q Institute of Biomedical Engineering, School of Medicine, Shandong University, Jinan, Shandong 250012, China; Institute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Oxford OX1 3PJ, - - 2014
Current electrocardiogram (ECG) signal quality assessment studies have aimed to provide a two-level classification: clean or noisy. However, clinical usage demands more specific noise level classification for varying applications. This work outlines a five-level ECG signal quality classification algorithm. A total of 13 signal quality metrics were derived from segments ...
Schmidt A A Biomagnetic Center, Hans Berger Department of Neurology, Jena University Hospital, Friedrich Schiller University, Jena, - - 2014
Fetal movements (FM) related heart rate accelerations (AC) are an important maturation criterion. Since Doppler-based time resolution is not sufficient for accompanying heart rate variability analysis, the work is aimed at a comprehensive FM-AC analysis using magnetocardiographic recordings from fetuses during sleep.We identify FM and AC by independent component analysis ...
Capik Canturk C Nursing Department, Ataturk University Faculty of Health Sciences, Erzurum, - - 2014
To assess the psychometric properties of a Likert-formatted assessment instrument after altering the responses to a dichotomous format. This methodological study used a 15-item instrument to obtain data from 183 participants who responded in both Likert and dichotomous formats. Response sets from each format were compared. Each response set underwent ...
Richard Ridderinkhof K K Dept. of Psychology, University of Amsterdam, Weesperplein 4, 1018 XA Amsterdam, the Netherlands; Amsterdam Brain & Cognition (ABC), University of Amsterdam, Nieuwe Achtergracht 10, 1018 WB Amsterdam, the Netherlands. Electronic address: - - 2014
The aim of the present review is to provide a theoretical analysis of the role of intentions in inhibition. We will first outline four dimensions along which inhibition can be categorized: intentionality, timing, specificity, and the nature of the to-be-inhibited action. Next, we relate the concept of inhibition to theories ...
Malengier Benny B Department of Textiles, Faculty of Engineering and Architecture, Ghent University, Ghent, - - 2014
Determining how effective a product is to repel mosquitoes or other flying insects is a difficult task. One approach is using a bioassay with textile fabric. We investigated the role of the textile substrate in the bioassay with a numerical model, and compared with known results for DEET. We next ...
Sharma Mukesh C MC Drug Design and Development Laboratory, School of Pharmacy, Devi Ahilya University, Takshila Campus, Khandwa Road, Indore, 452001, MP, India, - - 2014
Two Dimensional (2D) and Three Dimensional (3D) Quantitative Structure-Activity Relationship (QSAR) studies were performed for correlating the chemical composition of Imidazole-5-carboxylic Acids analogues and their Angiotensin II AT1 Receptor Antagonists activity using partial least squares and k Nearest Neighbor respectively. For Comparing the three different feature selection methods of 2D-QSAR, ...
Sharma Mukesh C MC Drug Research Laboratory, School of Pharmacy, Devi Ahilya University, Takshila Campus, Khandwa Road, Indore, (M.P), 452 001, India, - - 2014
To elucidate the structural properties required for antihypertensive activity, three different molecular modeling techniques; two-dimensional Quantitative structure activity relationship (2D-QSAR), Group-Based Quantitative structure activity relationship (G-QSAR), and three-dimensional Quantitative structure activity relationship (3D-QSAR) studies have been carried out on a series of substituted imidazolyl biphenyl sulfonylureas derivatives. Multiple linear regressions ...
Pavlovskiy Igor I Water & Earth System Science (WESS) Competence Cluster, c/o University of Tübingen, Hölderlinstaße 12, Tübingen, - - 2014
For karstified aquifer systems, numerical models of groundwater flow are difficult to setup and parameterize. However, a system understanding useful for groundwater management may be obtained without applying overly complicated models. In this study, we demonstrate for a karstified carbonate aquifer in south-western Germany that a combination of methods with ...
Sharma Mukesh C MC Drug Research Laboratory, School of Pharmacy, Devi Ahilya University, Takshila Campus, Khandwa Road, Indore, M.P, 452 001, India, - - 2014
A QSAR study has been performed on a series of pyridines derivatives with potent angiotensin II AT1 receptor antagonists. Structural features responsible for the activity of the compounds were characterized by using topological, electrotopological, group based and 3D descriptors, calculated from the Molecular Design Suite software (V-life MDS 3.5). To ...
Dwivedi Sanjiv K SK Complex Systems Lab, School of Basic Sciences, Indian Institute of Technology Indore, M-Block, IET-DAVV Campus Khandwa Road, Indore-452017, - - 2014
Though biological and artificial complex systems having inhibitory connections exhibit a high degree of clustering in their interaction pattern, the evolutionary origin of clustering in such systems remains a challenging problem. Using genetic algorithm we demonstrate that inhibition is required in the evolution of clique structure from primary random architecture, ...
Bozkurt Esra E Laboratory of Computational Chemistry and Biochemistry, Ecole Polytechnique Fédérale de Lausanne EPFL, Avenue Forel, CH-1015 Lausanne, - - 2014
Through millions of years of evolution, Nature has accomplished the development of highly efficient and sustainable processes and the idea to understand and copy natural strategies is therefore very appealing. However, in spite of intense experimental and computational research, it has turned out to be a difficult task to design ...
Aher Rahul Balasaheb - - 2014
Quantitative structure-activity relationship (QSAR)-based classification approach is one of the important chemometric tools in drug discovery process for categorizing the target protein inhibitors into more active and less active classes. In this background, we have presented here a novel approach of two-fold QSAR-based classification modeling for the Plasmodium falciparum carbonic ...
Liu An-An - - 2014
This paper proposes a unified framework for multiple/single-view human action recognition. First, we propose the hierarchical partwise bag-of-words representation which encodes both local and global visual saliency based on the body structure cue. Then, we formulate the multiple/single-view human action recognition as a part-regularized multitask structural learning (MTSL) problem which ...
Chen Lei L Research Center for Drug Discovery & Institute of Human Virology, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, 510006, - - 2014
The mammalian target of rapamycin (mTOR) is an anti-cancer target. In this study, we propose an in silico protocol for identifying mTOR inhibitors from the ZINC natural product database. First, a three-dimensional quantitative structure-activity relationship pharmacophore model was built based on known mTOR inhibitors. The model was validated with an ...
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