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Li Jia J a Department of Mathematical Sciences , University of Alabama in Huntsville , Huntsville , AL 35899 , - - 2015
To prevent the transmissions of malaria, dengue fever, or other mosquito-borne diseases, one effective weapon is the sterile insect technique in which sterile mosquitoes are released to reduce or eradicate the wild mosquito population. To study the impact of the sterile insect technique on disease transmission, we formulate discrete-time mathematical ...
Yi Qianying - - 2014
Nicotinamide phosphoribosyltransferase (NAMPT), an enzyme taking part in main NAD biosynthetic pathway, is an attractive target for anticancer therapy. The purpose of our study is to find novel NAMPT inhibitors based on in silico drug discovery means including the generation of 3D-QSAR models, and virtual screening techniques. Firstly, ten pharmacophore ...
Zhang Qi Q Pharmaceutical Analytical & Solid-State Chemistry Research Center, Shanghai Institute of Materia Medica , Chinese Academy of Sciences, Shanghai , - - 2014
Abstract Thermodynamic properties of polymorphic forms I and II of Agomelatine were investigated and the bimorphism was determined to be monotropically related. The phase transition kinetics from metastable form I to thermodynamically stable form II was studied and a quantification method was developed based on X-ray powder diffraction technique. Various ...
Devaraju N N Divecha Center for Climate Change & Center for Atmospheric and Oceanic Sciences Indian Institute of Science, Bangalore -560012, - - 2014
Land-use changes since the start of the industrial era account for nearly one-third of the cumulative anthropogenic CO2 emissions. In addition to the greenhouse effect of CO2 emissions, changes in land use also affect climate via changes in surface physical properties such as albedo, evapotranspiration, and roughness length. Recent modeling ...
Saab Rim R American University of Beirut, - - 2014
We examined predictors of collective action among bystander group members in solidarity with a disadvantaged group by extending the dual pathway model of collective action, which proposes one efficacy-based and one emotion-based path to collective action (Van Zomeren, Spears, Fischer, & Leach, 2004). Based on two proposed functions of social ...
Peach D D Department of Mathematics, Bates College, Lewiston, ME 04240, - - 2014
Though portable accelerometers are ubiquitous in physiology and public health studies, their accuracy as objective measures of physical activity is still being examined. This paper enumerates and analyzes the various biases of the widely used ActiLife(®) software in reporting activity counts from ActiGraph(®) accelerometers. In particular, we focus on the ...
Lievens Filip - - 2014
In assessment centers (ACs), research on eliciting candidate behavior and evaluating candidate behavior have largely followed independent paths. This study integrates trait activation and trait rating models to posit hypotheses about the effects of behavior elicitation via situational cues on key assessor observation and rating variables. To test the hypotheses, ...
Lu Wenhua W Department of Health & Kinesiology, Texas A&M University, College Station, TX, USA. - - 2014
To test a modified integrative model (IM) in explaining parents' intention toward active commuting to school (ACS) and children's ACS. Parents of fourth graders (N = 857) completed a survey assessing factors associated with ACS. A modified IM was developed and tested using structural equation modeling. The IM demonstrated good ...
Kumar Pritesh P a Department of Pharmacology and Toxicology , University of Louisville , Louisville , KY , - - 2014
The categorical structure-activity relationship (cat-SAR) expert system has been successfully used in the analysis of chemical compounds that cause toxicity. Herein we describe the use of this fragment-based approach to model ligands for the G protein-coupled receptor 119 (GPR119). Using compounds that are known GPR119 agonists and compounds that we ...
Andersson C David CD Department of Chemistry, Umeå University, 90187, Umeå, - - 2014
Scientific disciplines such as medicinal- and environmental chemistry, pharmacology, and toxicology deal with the questions related to the effects small organic compounds exhort on biological targets and the compounds' physicochemical properties responsible for these effects. A common strategy in this endeavor is to establish structure-activity relationships (SARs). The aim of ...
Chekkara Rajasekhar - - 2014
Polo-like kinase 1 (Plk1) is a decisive enzyme with its multifunctional activity in cell cycle progression especially mitosis. The over expression of Plk1 in broad spectrum of cancer types turn into a promising therapeutic target against cancer. In the present study, several ligand based pharmacophore models and atom based 3D-QSAR ...
Weirick Tyler - - 2014
Laccases (E.C. 1.10.3.2) are multi-copper oxidases that have gained importance in many industries such as biofuels, pulp production, textile dye bleaching, bioremediation, and food production. Their usefulness stems from the ability to act on a diverse range of phenolic compounds such as o-/p-quinols, aminophenols, polyphenols, polyamines, aryl diamines, and aromatic ...
McGuinn Tammy L TL Tammy L. McGuinn works as an adult gerontology nurse practitioner at Highland Family Practice in Lancaster, PA and is a clinical adjunct professor at York College of Pennsylvania, York, PA. Susan Scherr is a visiting assistant professor of nursing at York College of Pennsylvania, York, - - 2014
Warfarin is the most commonly prescribed oral anticoagulant. The management of warfarin is challenging, and current guidelines fail to include a model to assist practitioners in optimizing therapeutic dosing. The traditional model and the anticoagulation clinic (AC) model of warfarin management were compared and results found the AC model optimum.
Suthar Sharad Kumar SK Department of Pharmacy, Jaypee University of Information Technology, Waknaghat, 173234, - - 2014
NSAIDs are among the most widely prescribed medications across the world, but the gastrointestinal (GI) toxicity still remains the biggest problem and the challenge for current NSAIDs-based therapeutics. The development of selective COX-2 inhibitors was driven by the assumption that selective inhibition of COX-2 would reduce the GI side effects. ...
Chapleau Richard R - - 2014
One of the leading causes of death and illness within the agriculture industry is through unintentionally ingesting or inhaling organophosphate pesticides. OP intoxication directly inhibits acetylcholinesterase, resulting in an excitatory signaling cascade leading to fasciculation, loss of control of bodily fluids, and seizures. Our model was developed using a discrete, ...
Afzal Obaid O Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Hamdard University, New Delhi, - - 2014
The purpose of this study is to build up the 3D pharmacophore of Monoacylglycerol lipase (MAGL) inhibitor and to provide the basis to design the novel and potent MAGL inhibitors. A 3D-QSAR study on benztriazol-1-yl carboxamide derivatives as monoacylglycerol lipase (MAGL) inhibitors was successfully performed by means of pharmacophore mapping ...
Chailleux Anaïs A French National Institute for Agricultural Reseach (INRA), UMR1355-ISA, 400 route des chappes, 06903, Sophia-Antipolis, France; InVivo AgroSolutions, 83 Avenue de la grande Armée, 75582, Paris, France; CIRAD, UPR HortSys, F-34398, Montpellier, - - 2014
Understanding how arthropod pests and their natural enemies interact in complex agro-ecosystems is essential for pest management programs. Theory predicts that prey sharing a predator, such as a biological control agent, can indirectly reduce each other's density at equilibrium (apparent competition). From this premise, we (i) discuss the complexity of ...
Liang Geng G School of Control and Computer Engineering, North China Electric Power University, Beijing 102206, - - 2014
In this paper, improving control performance of a networked control system by reducing DTD in a different perspective was investigated. Two different network architectures for system implementation were presented. Analysis and improvement dealing with DTD for the experimental control system were expounded. Effects of control scheme configuration on DTD in ...
Kannan Srinivasaraghavan - - 2014
Schistosomiasis, caused by S. mansoni, is a tropical disease that affects over 200 million people worldwide. A novel approach for targeting eukaryotic parasites is to tackle their dynamic epigenetic machinery that is necessary for the extensive phenotypic changes during their life cycle. We recently identified S. mansoni histone deacetylase 8 ...
Wong Kai Y - - 2014
BackgroundThe evaluation of the clinical effects of Tacrine has shown efficacy in delaying the deterioration of the symptoms of Alzheimer¿s disease, while confirming the adverse events consisting mainly in the elevated liver transaminase levels. The study of tacrine analogs presents a continuous interest, and for this reason we establish Quantitative ...
Li Qiao Q Institute of Biomedical Engineering, School of Medicine, Shandong University, Jinan, Shandong 250012, China; Institute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Oxford OX1 3PJ, - - 2014
Current electrocardiogram (ECG) signal quality assessment studies have aimed to provide a two-level classification: clean or noisy. However, clinical usage demands more specific noise level classification for varying applications. This work outlines a five-level ECG signal quality classification algorithm. A total of 13 signal quality metrics were derived from segments ...
Schmidt A A Biomagnetic Center, Hans Berger Department of Neurology, Jena University Hospital, Friedrich Schiller University, Jena, - - 2014
Fetal movements (FM) related heart rate accelerations (AC) are an important maturation criterion. Since Doppler-based time resolution is not sufficient for accompanying heart rate variability analysis, the work is aimed at a comprehensive FM-AC analysis using magnetocardiographic recordings from fetuses during sleep.We identify FM and AC by independent component analysis ...
Capik Canturk C Nursing Department, Ataturk University Faculty of Health Sciences, Erzurum, - - 2014
To assess the psychometric properties of a Likert-formatted assessment instrument after altering the responses to a dichotomous format. This methodological study used a 15-item instrument to obtain data from 183 participants who responded in both Likert and dichotomous formats. Response sets from each format were compared. Each response set underwent ...
Richard Ridderinkhof K K Dept. of Psychology, University of Amsterdam, Weesperplein 4, 1018 XA Amsterdam, the Netherlands; Amsterdam Brain & Cognition (ABC), University of Amsterdam, Nieuwe Achtergracht 10, 1018 WB Amsterdam, the Netherlands. Electronic address: - - 2014
The aim of the present review is to provide a theoretical analysis of the role of intentions in inhibition. We will first outline four dimensions along which inhibition can be categorized: intentionality, timing, specificity, and the nature of the to-be-inhibited action. Next, we relate the concept of inhibition to theories ...
Malengier Benny B Department of Textiles, Faculty of Engineering and Architecture, Ghent University, Ghent, - - 2014
Determining how effective a product is to repel mosquitoes or other flying insects is a difficult task. One approach is using a bioassay with textile fabric. We investigated the role of the textile substrate in the bioassay with a numerical model, and compared with known results for DEET. We next ...
Sharma Mukesh C MC Drug Design and Development Laboratory, School of Pharmacy, Devi Ahilya University, Takshila Campus, Khandwa Road, Indore, 452001, MP, India, - - 2014
Two Dimensional (2D) and Three Dimensional (3D) Quantitative Structure-Activity Relationship (QSAR) studies were performed for correlating the chemical composition of Imidazole-5-carboxylic Acids analogues and their Angiotensin II AT1 Receptor Antagonists activity using partial least squares and k Nearest Neighbor respectively. For Comparing the three different feature selection methods of 2D-QSAR, ...
Sharma Mukesh C MC Drug Research Laboratory, School of Pharmacy, Devi Ahilya University, Takshila Campus, Khandwa Road, Indore, (M.P), 452 001, India, - - 2014
To elucidate the structural properties required for antihypertensive activity, three different molecular modeling techniques; two-dimensional Quantitative structure activity relationship (2D-QSAR), Group-Based Quantitative structure activity relationship (G-QSAR), and three-dimensional Quantitative structure activity relationship (3D-QSAR) studies have been carried out on a series of substituted imidazolyl biphenyl sulfonylureas derivatives. Multiple linear regressions ...
Pavlovskiy Igor I Water & Earth System Science (WESS) Competence Cluster, c/o University of Tübingen, Hölderlinstaße 12, Tübingen, - - 2014
For karstified aquifer systems, numerical models of groundwater flow are difficult to setup and parameterize. However, a system understanding useful for groundwater management may be obtained without applying overly complicated models. In this study, we demonstrate for a karstified carbonate aquifer in south-western Germany that a combination of methods with ...
Sharma Mukesh C MC Drug Research Laboratory, School of Pharmacy, Devi Ahilya University, Takshila Campus, Khandwa Road, Indore, M.P, 452 001, India, - - 2014
A QSAR study has been performed on a series of pyridines derivatives with potent angiotensin II AT1 receptor antagonists. Structural features responsible for the activity of the compounds were characterized by using topological, electrotopological, group based and 3D descriptors, calculated from the Molecular Design Suite software (V-life MDS 3.5). To ...
Dwivedi Sanjiv K SK Complex Systems Lab, School of Basic Sciences, Indian Institute of Technology Indore, M-Block, IET-DAVV Campus Khandwa Road, Indore-452017, - - 2014
Though biological and artificial complex systems having inhibitory connections exhibit a high degree of clustering in their interaction pattern, the evolutionary origin of clustering in such systems remains a challenging problem. Using genetic algorithm we demonstrate that inhibition is required in the evolution of clique structure from primary random architecture, ...
Aher Rahul Balasaheb - - 2014
Quantitative structure-activity relationship (QSAR)-based classification approach is one of the important chemometric tools in drug discovery process for categorizing the target protein inhibitors into more active and less active classes. In this background, we have presented here a novel approach of two-fold QSAR-based classification modeling for the Plasmodium falciparum carbonic ...
Liu An-An - - 2014
This paper proposes a unified framework for multiple/single-view human action recognition. First, we propose the hierarchical partwise bag-of-words representation which encodes both local and global visual saliency based on the body structure cue. Then, we formulate the multiple/single-view human action recognition as a part-regularized multitask structural learning (MTSL) problem which ...
Chen Lei L Research Center for Drug Discovery & Institute of Human Virology, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, 510006, - - 2014
The mammalian target of rapamycin (mTOR) is an anti-cancer target. In this study, we propose an in silico protocol for identifying mTOR inhibitors from the ZINC natural product database. First, a three-dimensional quantitative structure-activity relationship pharmacophore model was built based on known mTOR inhibitors. The model was validated with an ...
Lin Yangchen Y Conservation Science Group, Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, United Kingdom. Electronic address: - - 2014
Interaction modification (IM), where one species modifies the strength of the density-mediated direct interaction between two other species, is an important ecological process, but little is known about the collective effect of multiple IM on overall community dynamics. We use stochastic bioenergetic modelling of ecological networks with different network topologies, ...
Baghestan K K Mechanical Engineering Department, Amirkabir University of Technology, Tehran, Iran. Electronic address: - - 2014
Electro-hydraulic servo systems (EHSS) are used in many industrial applications for position and force control. Force control with a hydraulic actuator is challenging and requires complicated control algorithms used along with high crossover frequency electro-hydraulic valves, even for simple force control tasks. In this paper, a different hydraulic structure is ...
Wu Cen C Department of Biostatistics, School of Public Health, Yale University, 60 College Street, New Haven, CT, 06520, - - 2014
Consider the integrative analysis of genetic data with multiple correlated response variables. The goal is to identify important gene-environment (G × E) interactions along with main gene and environment effects that are associated with the responses. The homogeneity and heterogeneity models can be adopted to describe the genetic basis of ...
Carlsson Magnus M Department of Health and Social Sciences, Dalarna University, Högskolegatan 2, 791 88, Falun, Sweden, - - 2014
To investigate the relationship between sprint-prologue performance (using the classical technique) and the oxygen uptake at the lactate threshold ([Formula: see text] 2obla), maximal oxygen uptake ([Formula: see text] 2max), and mean oxygen uptake during double poling ([Formula: see text] 2dp). Eight elite male cross-country skiers [age 24.8 ± 4.8 years, (mean ± SD)] completed ...
Rossow Heidi A HA Population Health and Reproduction, School of Veterinary Medicine, and - - 2014
The goal of this research was to use a computational model of human metabolism to predict energy metabolism for lean and obese men. The model is composed of 6 state variables representing amino acids, muscle protein, visceral protein, glucose, triglycerides, and fatty acids (FAs). Differential equations represent carbohydrate, amino acid, ...
Vanee Niti - - 2014
Background Thermobifida fusca is a cellulolytic bacterium with potential to be used as a platform organism for sustainable industrial production of biofuels, pharmaceutical ingredients and other bioprocesses due to its capability of potential to convert plant biomass to value-added chemicals. To best develop T. fusca as a bioprocess organism, it ...
Contrera Ronan Cleber RC Departamento de Engenharia Hidráulica e Ambiental (PHD), Escola Politécnica (EP), Universidade de São Paulo (USP), Avenida Prof. Almeida Prado, 83 trav. 2, Cidade Universitária, CEP: 05508-900 São Paulo, SP, Brazil. Electronic address: - - 2014
This paper reports the kinetics evaluation of landfill leachate anaerobic treatment in a pilot-scale Anaerobic Sequence Batch Biofilm Reactor (AnSBBR). The experiment was carried out at room temperature (23.8 ± 2.1 °C) in the landfill area in São Carlos-SP, Brazil. Biomass from the bottom of a local landfill leachate stabilization pond was used ...
Spandonaro F F CREA Sanità (Consortium for Applied Economic Research in Health), University of Rome Tor Vergata, Via Columbia 2, 00133, Rome, Italy, - - 2014
Growth hormone (GH) consumption is the object of a particular attention by regulatory bodies, due to its financial impact; nevertheless, GH treatment has been demonstrated to be cost-effective and is, therefore, usually reimbursed by public health service systems. In Italy, significant differences in GH consumption between regions have been recorded. ...
Abrams Peter A PA Department of Ecology and Evolutionary Biology, University of Toronto, 25 Harbord St., Toronto, Ontario, M5S 3G5, - - 2014
The history of the idea that predation rates are functions of the ratio of prey density to predator density, known as ratio dependence, is reviewed and updated. When the term was introduced in 1989, it was already known that higher predator abundance often reduced an individual predator's average intake rate ...
Carré Matthieu M UM2-CNRS-IRD, Institut des Sciences de l'Evolution de Montpellier, UMR 5554, Pl. Eugène Bataillon, 34095 Montpellier, France. - - 2014
Understanding the response of the El Niño-Southern Oscillation (ENSO) to global warming requires quantitative data on ENSO under different climate regimes. Here, we present a reconstruction of ENSO in the eastern tropical Pacific spanning the last 10 thousand years (ka) derived from oxygen isotopes in fossil mollusk shells from Peru. ...
Martin-Sampedro Raquel R Cellulose and Paper Laboratory, Forest Product Department, INIA-CIFOR, Carretera de la Coruña, km 7.5, 28040, Madrid, Spain, - - 2014
A laccase stage can be used as a pre-treatment of a standard chemical bleaching sequence to reduce environmental concerns associated to this process. The importance of each independent variable and its influence on the properties of the bleached pulp have been studied in depth in this work, using an adaptive ...
Heddam Salim - - 2014
In this study, a comparison between generalized regression neural network (GRNN) and multiple linear regression (MLR) models is given on the effectiveness of modelling dissolved oxygen (DO) concentration in a river. The two models are developed using hourly experimental data collected from the United States Geological Survey (USGS Station No: ...
Zhang Jie - - 2014
Multi-Electrode Arrays (MEA) have been widely used in neuroscience experiments. However, the reduction of their wireless transmission power consumption remains a major challenge. To resolve this challenge, an efficient on-chip signal compression method is essential. In this paper, we first introduce a signal-dependent Compressed Sensing (CS) approach that outperforms previous ...
Agrawal Gaurav G School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA 30332, - - 2014
In this article, we extend the simulated moving bed reactor (SMBR) mode of operation to the production of propylene glycol methyl ether acetate (DOWANOL™ PMA glycol ether) through the esterification of 1-methoxy-2-propanol (DOWANOL™ PM glycol ether) and acetic acid using AMBERLYST™ 15 as a catalyst and adsorbent. In addition, for ...
Rong Weibin W State Key Laboratory of Robotics and System, Harbin Institute of Technology, Harbin, Heilongjiang, - - 2014
Pick-and-place of micro-objects is a basic task in various micromanipulation demands. Reliable releasing of micro-objects is usually disturbed due to strong scale effects. This paper focuses on a vacuum micro-gripper with vibration releasing functionality, which was designed and assembled for reliable micromanipulation tasks. Accordingly, a vibration releasing strategy of implementing ...
Osth Jonas J Chalmers University of Technology, Department of Applied Mechanics, Division of Vehicle Safety, Gothenburg, Sweden. Electronic address: - - 2014
Human body models (HBMs) for vehicle occupant simulations have recently been extended with active muscles and postural control strategies. Feedback control has been used to model occupant responses to autonomous braking interventions. However, driver postural responses during driver initiated braking differ greatly from autonomous braking. In the present study, an ...
Russ Stefanie S Institut für Theoretische Physik, Arnimallee 14, Freie Universität Berlin, 14195 Berlin, - - 2014
It is shown that a two-component percolation model on a simple cubic lattice can explain an experimentally observed behavior [Savage et al., Sens. Actuators B 79, 17 (2001); Sens. Actuators B 72, 239 (2001).], namely, that a network built up by a mixture of sintered nanocrystalline semiconducting n and p ...
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