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Caughlin T Trevor TT Department of Biology, University of Florida, PO Box 118525, Gainesville, FL 32611, USA Conservation Ecology Program, King Mongkut's University of Technology Thonburi, 49 Soi Tientalay 25, Bangkhuntien-Chaitalay Road, Thakham, Bangkhuntien, Bangkok 10150, Thailand - - 2015
Overhunting in tropical forests reduces populations of vertebrate seed dispersers. If reduced seed dispersal has a negative impact on tree population viability, overhunting could lead to altered forest structure and dynamics, including decreased biodiversity. However, empirical data showing decreased animal-dispersed tree abundance in overhunted forests contradict demographic models which predict ...
Ma David K G DK Garvan Institute of Medical Research, Sydney, NSW, Australia, - - 2015
Data visualisation is usually a crucial first step in analysing and exploring large-scale complex data. The visualisation of proteomics time-course data on post-translational modifications presents a particular challenge that is largely unmet by existing tools and methods. To this end, we present Minardo, a novel visualisation strategy tailored for such ...
Moore Jason H JH Department of Genetics, Geisel School of Medicine, DHMC, One Medical Center Dr., HB 7937, Lebanon, NH, 03756, USA, - - 2015
Here we introduce the multifactor dimensionality reduction (MDR) methodology and software package for detecting and characterizing epistasis in genetic association studies. We provide a general overview of the method and then highlight some of the key functions of the open-source MDR software package that is freely distributed. We end with ...
Holder Andre L AL Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, - - 2015
The development and resolution of cardiopulmonary instability take time to become clinically apparent, and the treatments provided take time to have an impact. The characterization of dynamic changes in hemodynamic and metabolic variables is implicit in physiologic signatures. When primary variables are collected with high enough frequency to derive new ...
Wu Xiaohui X Department of Automation, Xiamen University, 422 Siming South Road, Xiamen, Fujian, 361005, China, - - 2015
Messenger RNA polyadenylation is one of the essential processing steps during eukaryotic gene expression. The site of polyadenylation [poly(A) site] marks the end of a transcript, which is also the end of a gene in most cases. A computation program that is able to recognize poly(A) sites would not only ...
Nisbet Rebecca M RM Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, Brisbane, Australia, - - 2014
Neurofibrillary tangles and amyloid plaques constitute the hallmark brain lesions of Alzheimer's disease (AD) patients. Tangles are composed of fibrillar aggregates of the microtubule-associated protein tau, and plaques comprise fibrillar forms of a proteolytic cleavage product, amyloid-β (Aβ). Although plaques and tangles are the end-stage lesions in AD, small oligomers ...
Markiewicz P J PJ Translational Imaging Group, CMIC, University College London, 3rd Floor, Wolfson House, 4 Stephenson Way, London NW12HE, UK. Imaging Sciences, Wolfson Molecular Imaging Centre, MAHSC, University of Manchester, Oxford Rd, Manchester M13 9PL, - - 2014
Bootstrap resampling has been successfully used for estimation of statistical uncertainty of parameters such as tissue metabolism, blood flow or displacement fields for image registration. The performance of bootstrap resampling as applied to PET list-mode data of the human brain and dedicated phantoms is assessed in a novel and systematic ...
Niu Liang - - 2014
Abstract Chromatin interactions mediated by a particular protein are of interest for studying gene regulation, especially the regulation of genes that are associated with, or known to be causative of, a disease. A recent molecular technique, Chromatin interaction analysis by paired-end tag sequencing (ChIA-PET), that uses chromatin immunoprecipitation (ChIP) and ...
Han Yaofeng Y aKey Laboratory of Health Technology Assessment of Fujian Province University, School of Public Health, Xiamen University bState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University cDepartment of Nuclear Medicine, Xiamen Cancer Center, The First Affliated Hospital of Xiamen University, Xiamen, People's Republic of - - 2014
The aim of the study was to establish the most cost-effective strategy for using integrated F-fluorodeoxyglucose PET and computed tomography (CT) for mediastinal lymph node staging (N-staging) of preoperative non-small-cell lung cancer (NSCLC). Four N-staging decision models for operative NSCLC, model A (CT only), model B (PET/CT for negative CT), ...
Gandjour Afschin A Frankfurt School of Finance and Management, Frankfurt, - - 2014
Aim: The aim of this paper is to develop a simulation model that analyzes cost-offsets of a hypothetical disease management program (DMP) for patients with chronic kidney disease (CKD) in Germany compared to no such program. Methods: A lifetime Markov model with simulated 65-year-old patients with CKD was developed using ...
Onal S S Department of Mechanical and Industrial Engineering, Southern Illinois University-Edwardsville, Edwardsville, IL, - - 2014
The objective of this study was to quantitatively assess the ability of new MRI-based measurements to differentiate low and high stages of pelvic organ prolapse. New measurements representing pelvic structural characteristics are proposed and analyzed using support vector machines (SVM). This retrospective study used data from 207 women with different ...
Jones David T DT Bioinformatics Group, Department of Computer Science, University College London, Gower Street, London, WC1E 6BT, UK. - - 2014
Recent developments of statistical techniques to infer direct evolutionary couplings between residue pairs have rendered covariation-based contact prediction a viable means for accurate 3-D modelling of proteins, with no information other than the sequence required. To extend the usefulness of contact prediction, we have designed a new meta-predictor (MetaPSICOV) which ...
Koletzko Svenja H SH University of Zurich, - - 2014
This research introduces low goal ambivalence as a relevant correlate of goal self-concordance. In three studies, we tested the hypothesis that university freshmen's ambivalence toward the goal of completing their degree mediates the effect of goal self-concordance on subjective well-being. In Studies 1 and 2, differences in goal ambivalence accounted ...
Liu Pengbo P Key Laboratory of High-efficiency and Clean Mechanical Manufacture (Shandong University), Ministry of Education, School of Mechanical Engineering, Shandong University, Jinan, Shandong 250061, - - 2014
In this paper, a novel X-Y parallel piezoelectric-actuator driven nanopositioner is studied from the perspectives of design optimization, dynamical modeling, as well as controller synthesis for high precision positioning. FEM (Finite Element Method) and dynamical modeling are provided to analyze the mechatronic structure of the proposed two-dimensional nano-stage, where the ...
Muschick Moritz M Zoological Institute, University of Basel, Basel 4051, Switzerland Department of Animal and Plant Sciences, University of Sheffield, Sheffield S10 2TN, - - 2014
Adaptive radiation (AR) is a key process in the origin of organismal diversity. However, the evolution of trait disparity in connection with ecological specialization is still poorly understood. Available models for vertebrate ARs predict that diversification occurs in the form of temporal stages driven by different selective forces. Here, we ...
Gaidatzis Dimos D Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4058 Basel, Switzerland Swiss Institute of Bioinformatics, Maulbeerstrasse 66, 4058 Basel, - - 2014
QuasR is a package for the integrated analysis of high-throughput sequencing data in R, covering all steps from read preprocessing, alignment and quality control to quantification. QuasR supports different experiment types (including RNA-seq, ChIP-seq and Bis-seq) and analysis variants (e.g. paired-end, stranded, spliced and allele-specific), and is integrated in Bioconductor ...
Rudenstine Sasha S Department of Epidemiology,Columbia University,New York,New - - 2014
We propose a model of population behavior in the aftermath of disasters. We conducted a qualitative analysis of an empirical dataset of 339 disasters throughout the world spanning from 1950 to 2005. We developed a model of population behavior that is based on 2 fundamental assumptions: (i) behavior is predictable ...
Hu Mian M School of Environmental Science & Engineering, Huazhong University of Science and Technology, Wuhan 430074, - - 2014
The pyrolysis process of two microalgae, Chlorella pyrenoidosa (CP) and bloom-forming cyanobacteria (CB) was examined by thermo-gravimetry to investigate their thermal decomposition behavior under non-isothermal conditions. It has found that the pyrolysis of both microalgae consists of three stages and stage II is the major mass reduction stage with mass ...
Myers Casey A CA Center for Orthopaedic Biomechanics, Department of Mechanical and Materials Engineering, University of Denver, 2390 S. York St, Denver, CO, 80208, - - 2014
Uncertainty that arises from measurement error and parameter estimation can significantly affect the interpretation of musculoskeletal simulations; however, these effects are rarely addressed. The objective of this study was to develop an open-source probabilistic musculoskeletal modeling framework to assess how measurement error and parameter uncertainty propagate through a gait simulation. ...
Tamm M M Miriam Tamm, RWTH Aachen University, Department of Medical Statistics, Pauwelsstraße 30, 52074 Aachen, - - 2014
Background: In clinical trials patients are commonly recruited sequentially over time incurring the risk of chronological bias due to (unobserved) time trends. To minimize the risk of chronological bias, a suitable randomization procedure should be chosen. Objectives: Considering different time trend scenarios, we aim at a detailed evaluation of the ...
Haug Joachim T JT Functional Morphology, Department of Biology II, GeoBio-Center, LMU Munich, Großhaderner Str. 2, 82152, Planegg-Martinsried, - - 2014
The nymphal stages of Palaeozoic insects differ significantly in morphology from those of their modern counterparts. Morphological details for some previously reported species have recently been called into question. Palaeozoic insect nymphs are important, however - their study could provide key insights into the evolution of wings, and complete metamorphosis. ...
Noé Laurent L 1 Laboratoire d'Informatique Fondamentale de Lille (LIFL) (UMR 8022 Lille 1/CNRS) - Inria Lille, Villeneuve d'Ascq, France - - 2014
Abstract Spaced seeds have been recently shown to not only detect more alignments, but also to give a more accurate measure of phylogenetic distances, and to provide a lower misclassification rate when used with Support Vector Machines (SVMs). We confirm by independent experiments these two results, and propose in this ...
Foster Jared C JC Department of Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA and Biostatistics and Bioinformatics Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20852, USA - - 2014
We consider the use of randomized clinical trial (RCT) data to identify simple treatment regimes based on some subset of the covariate space, [Formula: see text]. The optimal subset, [Formula: see text], is selected by maximizing the expected outcome under a treat-if-in-[Formula: see text] regime, and is restricted to be ...
Mahdi Taha T Institute of Hydrogen Economy, Universiti Teknologi Malaysia, 81310 Johor Bahru, Malaysia; Faculty of Chemical Engineering, Universiti Teknologi Malaysia, 81310 Johor Bahru, Malaysia; Midland Refineries Company, Ministry of Oil, Daura, Baghdad, - - 2014
The ability of sonication phenomena in facilitating separation of azeotropic mixtures presents a promising approach for the development of more intensified and efficient distillation systems than conventional ones. To expedite the much-needed development, a mathematical model of the system based on conservation principles, vapor-liquid equilibrium and sonochemistry was developed in ...
Liu Li L School of Elec. & Info., Tianjin University, Nankai District, Tianjin 300072, PR China. Electronic address: - - 2014
In this paper, we propose two reconstruction algorithms for sparse-view X-ray computed tomography (CT). Treating the reconstruction problems as data fidelity constrained total variation (TV) minimization, both algorithms adapt the alternate two-stage strategy: projection onto convex sets (POCS) for data fidelity and non-negativity constraints and steepest descent for TV minimization. ...
Tang Zhongwen - - 2014
Abstract An analytical way to compute predictive probability of success (PPOS) together with credible interval at interim analysis (IA) is developed for big clinical trials with time to event end points. The method takes account of the fixed data up to IA, the amount of uncertainty in future data, and ...
Arifin Sm Niaz - - 2014
Agent-based models (ABMs) have been used to model the behaviour of individual mosquitoes and other aspects of malaria. In this paper, a conceptual entomological model of the population dynamics of Anopheles gambiae and the agent-based implementations derived from it are described. Hypothetical vector control interventions (HVCIs) are implemented to target ...
Laurie Cecelia - - 2014
BackgroundHow to map quantitative trait loci (QTL) with epistasis efficiently and reliably has been a persistent problem for QTL mapping analysis. There are a number of difficulties for studying epistatic QTL. Linkage can impose a significant challenge for finding epistatic QTL reliably. If multiple QTL are in linkage and have ...
Li Xianwei - - 2014
Based on a two-stage heuristic method, this paper is concerned with the design of robust feedback controllers with restricted frequency-domain specifications (RFDSs) for uncertain linear discrete-time systems. Polytopic uncertainties are assumed to enter all the system matrices, while RFDSs are motivated by the fact that practical design specifications are often ...
Su B Y - - 2014
We propose in this paper the use of Wavelet transform (WT) to detect human falls using a ceiling mounted Doppler range control radar. The radar senses any motions from falls as well as nonfalls due to the Doppler effect. The wavelet transform is very effective in distinguishing the falls from ...
Yuan Miaolong - - 2014
Feature point recognition is a key component in many vision-based applications, such as vision-based robot navigation, object recognition and classification, image-based modeling, and augmented reality. Real-time performance and high recognition rates are of crucial importance to these applications. In this brief, we propose a novel method for real-time keypoint recognition ...
Generous Nicholas N Defense Systems and Analysis Division, Los Alamos National Laboratory, Los Alamos, New Mexico, United States of - - 2014
Infectious disease is a leading threat to public health, economic stability, and other key social structures. Efforts to mitigate these impacts depend on accurate and timely monitoring to measure the risk and progress of disease. Traditional, biologically-focused monitoring techniques are accurate but costly and slow; in response, new techniques based ...
Kakourou Alexia A 1 Department of Medical Statistics and Bioinformatics, Leiden University Medical Center , Leiden, The Netherlands - - 2014
Abstract We consider a proteomic mass spectrometry case-control study for the construction of a diagnostic rule for patients' disease status allocation. We propose an approach for combining a collection of classifiers for the construction of a "combined" classification rule in order to enhance calibration and prediction ability. In a first ...
Bacaita E S ES Department of Physics, "Gheorghe Asachi" Technical University of Iasi, Prof. Dr. docent Dimitrie Mangeron Rd., No. 73, Iasi 700050, Romania. - - 2014
The study proposes modeling calcein release kinetics (considered as a hydrophilic drug model) from an interpenetrating network matrix of hydrogels, based on the combination of two polymers, of which chitosan is the most commonly used polymer. The release process is analyzed for different increasing time intervals, based on the evolution ...
Gouvinhas Irene I CITAB - CITAB, University of Trás-os-Montes and Alto Douro, 5001-801 Vila Real, Portugal. Electronic address: - - 2015
Extra virgin olive oils produced from three cultivars on different maturation stages were characterized using Raman spectroscopy. Chemometric methods (principal component analysis, discriminant analysis, principal component regression and partial least squares regression) applied to Raman spectral data were utilized to evaluate and quantify the statistical differences between cultivars and their ...
Corsini Chiara C Laboratory of Biological Structure Mechanics, Department of Chemistry, Materials and Chemical Engineering 'Giulio Natta', Politecnico di Milano, Milan, - - 2014
Newborns with single ventricle physiology are usually palliated with a multi-staged procedure. When cardiovascular complications e.g., collateral vessel formation occur during the inter-stage periods, further treatments are required. An 8-month-old patient, who underwent second stage (i.e., bi-directional Glenn, BDG) surgery at 4 months, was diagnosed with a major veno-venous collateral vessel ...
Landi Pietro P Department of Eletronics, Information, and Bioengineering, Politecnico di Milano, Via Ponzio 34/5, 20133 Milano, Italy. Electronic address: - - 2014
Commercial harvesting is recognized to induce adaptive responses of life-history traits in fish populations, in particular by shifting the age and size at maturation through directional selection. In addition to such evolution of a target stock, the corresponding fishery itself may adapt, in terms of fishing policy, technological progress, fleet ...
Rienksma Rienk A RA Laboratory of Systems and Synthetic Biology, Wageningen University and Research Centre, Dreijenplein 10, Wageningen 6703 HB, The - - 2014
Systems-level metabolic network reconstructions and the derived constraint-based (CB) mathematical models are efficient tools to explore bacterial metabolism. Approximately one-fourth of the Mycobacterium tuberculosis (Mtb) genome contains genes that encode proteins directly involved in its metabolism. These represent potential drug targets that can be systematically probed with CB models through ...
Pereira A A Department of Hand Surgery, Strasbourg University Hospital, FMTS, University of Strasbourg, Icube CNRS UMR7357, 10, avenue Baumann, 67403 Illkirch, - - 2014
The aim of this study was to establish the feasibility of microsurgical end-to-side vascular anastomosis with a multiclamp adjustable vascular clamp prototype in an inert experimental model. Our method consisted of performing an end-to-side microsurgical anastomosis with 10/0 suture on a 2-mm diameter segment. In group 1, the end-to-side segment ...
Ryan Devon Patrick - - 2014
DNA methylation changes are associated with a wide array of biological processes. Bisulfite conversion of DNA followed by high-throughput sequencing is increasingly being used to assess genome-wide methylation at single-base resolution. The relative slowness of most commonly used aligners for processing such data introduces an unnecessarily long delay between receipt ...
Pfaff T T Institute of Condensed Matter Physics, Hochschulstraße 6, 64289 Darmstadt, Germany. Electronic address: - - 2014
We study a simple model for generation cycles, which are oscillations with a period of one or a few generation times of the species. The model is formulated in terms of a single delay-differential equation for the population density of an adult stage, with recruitment to the adult stage depending ...
Lemos-Giráldez Serafín S University of Oviedo, Oviedo, Spain; Centro de Investigación en Red de Salud Mental (Center for Biomedical Research in the Mental Health Network, CIBERSAM), Madrid, Spain. Electronic address: - - 2014
Mental health consumers invite us to abandon the pathology model, which is tied to pessimism, and instead to embrace a model of personal recovery that goes beyond being free from symptoms, and involves self-management of the illness. The Stages of Recovery Instrument (STORI) is a measure developed from the perspective ...
Lange Jane M JM Department of Bioststatistics, University of Washington, Seattle, Washington, - - 2014
Multistate models are used to characterize individuals' natural histories through diseases with discrete states. Observational data resources based on electronic medical records pose new opportunities for studying such diseases. However, these data consist of observations of the process at discrete sampling times, which may either be pre-scheduled and non-informative, or ...
Lu Kaifeng K Forest Laboratories, Harborside Financial Center, Jersey City, USA - - 2014
Multiple imputation procedures replace each missing value with a set of plausible values based on the posterior predictive distribution of missing data given observed data. In many applications, as few as five imputations are adequate to achieve high efficiency relative to an infinite number of imputations. However, substantially more imputations ...
Roll Shawn C SC Division of Occupational Science and Occupational Therapy, University of Southern California, Los Angeles, CA, - - 2014
Introduction: Ultrasonography may be valuable in staging carpal tunnel syndrome severity, especially by combining multiple measures. This study aimed to develop a preliminary severity staging model using multiple sonographic and clinical measures. Methods: Measures were obtained in 104 participants. Multiple categorization structures for each variable were correlated to diagnostic severity ...
Richards David M DM Department of Life Sciences, Imperial College, London, United Kingdom; Centre for Integrative Systems Biology and Bioinformatics, Imperial College, London, United Kingdom. Electronic address: - - 2014
Despite being of vital importance to the immune system, the mechanism by which cells engulf relatively large solid particles during phagocytosis is still poorly understood. From movies of neutrophil phagocytosis of polystyrene beads, we measure the fractional engulfment as a function of time and demonstrate that phagocytosis occurs in two ...
Simic Vladimir V University of Belgrade, Faculty of Transport and Traffic Engineering, Vojvode Stepe 305, 11000 Belgrade, Serbia. Electronic address: - - 2014
End-of-life vehicles (ELVs) are vehicles that have reached the end of their useful lives and are no longer registered or licensed for use. The ELV recycling problem has become very serious in the last decade and more and more efforts are made in order to reduce the impact of ELVs ...
Zhao Jianhua - - 2014
This paper concerns model selection for mixtures of probabilistic principal component analyzers (MPCA). The well known Bayesian information criterion (BIC) is frequently used for this purpose. However, it is found that BIC penalizes each analyzer implausibly using the whole sample size. In this paper, we present a new criterion for ...
Wang Shuming - - 2014
In the context of robust optimization with information granules for distributional parameters, this paper investigates a two-stage waste-to-energy feedstock flow planning problem with uncertain capacity expansion costs. The objective is to minimize the worst-case overall loss in a mean-risk criterion where the risk is measured by a conditional value-at-risk operator. ...
Pokharel Gyanendra G Department of Mathematics and Statistics, University of Guelph, ON N1G2W1, Canada. Electronic address: - - 2014
Parameter estimation for mechanistic models of infectious disease can be computationally intensive. Nsoesie et al. (2011) introduced an approach for inference on infectious disease data based on the idea of supervised learning. Their method involves simulating epidemics from various infectious disease models, and using classifiers built from the epidemic curve ...
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