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Piñero David P DP Department of Ophthalmology (Oftalmar), Medimar International Hospital, Alicante, Spain; Foundation for the Visual Quality, Fundación para la Calidad Visual, Alicante, Spain; Departament of Optics, Pharmacology and Anatomy, University of Alicante, - - 2014
Biomechanics is often defined as 'mechanics applied to biology'. Due to the variety and complexity of the behaviour of biological structures and materials, biomechanics is better defined as the development, extension and application of mechanics for a better understanding of physiology and physiopathology and consequently for a better diagnosis and ...
Riddlesworth Tonya T N/A, Jaeb Center for Health Research, 15310 Amberly Dr, Tampa, FL, 33647, United States - - 2014
Purpose: To find a mathematical model that predicts endothelial cell density (ECD) for patients after penetrating keratoplasty (PK) for a moderate-risk condition (principally Fuchs' dystrophy or pseudophakic/aphakic corneal edema). Methods: In a subset (N=591) of Cornea Donor Study participants, postoperative ECD was determined by a central reading center. Various statistical ...
Schroer Kes K Neukom Institute for Computational Science, Dartmouth, Hanover, NH, USA; Department of Anthropology, Dartmouth, Hanover, NH, - - 2014
The inhibitory cascade is a mathematical model for interpreting the relative size of the occlusal surfaces of mammalian molars in terms of developmental mechanisms. The cascade is derived from experimental studies of mouse molars developed in culture, and has been tested and applied to the dentitions of rodents, ungulates, carnivores, ...
Fabrice Chuembou Pekam CP Chair of Medical Engineering, RWTH Aachen University, Aachen, Germany. Electronic address: - - 2014
Because of its ability to non-invasively capture hard structures behind soft tissue, high-frequency ultrasound (HFUS)-assisted microscanning could be a patient-friendly and promising alternative for digitization of prepared teeth. However, intra-oral HFUS microscanners for taking digital impressions of prepared teeth are still not available in the clinical setting. Because working range, ...
Lago M A MA LabHuman, Universitat Politècnica de València, Camino de Vera s/n, 46022 Valencia, Spain. Electronic address: - - 2014
This work presents a methodology for the in vivo characterization of the complete biomechanical behavior of the human cornea of each patient. Specifically, the elastic constants of a hyperelastic, second-order Ogden model were estimated for 24 corneas corresponding to 12 patients. The finite element method was applied to simulate the ...
Whitford Charles C School of Engineering, University of Liverpool, UK. Electronic address: - - 2014
A numerical model based on continuum mechanics theory has been developed which represents the 3D anisotropic behaviour of the corneal stroma. Experimental data has been gathered from a number of previous studies to provide the basis and calibration parameters for the numerical modelling. The resulting model introduces numerical representation of ...
Bourges J L JL Centre d'ophtalmologie HUPC, hôpital Hôtel-Dieu, Assistance publique-Hôpitaux de Paris, 1, place du Parvis-Notre-Dame, 75181 Paris cedex 04, France; Faculté de médicine Paris Descartes, université Sorbonne Paris Cité, 15, rue de l'École-de-Médecine, 75006 Paris, - - 2014
Oriented collagen biosynthesis is one of the major mechanisms involved in tissue and organ formation during development. Corneal biogenesis is one example. Defects in this process lead to anomalies in tissue structure and function. The transparency of cornea and its achievement are a good example as well as its pathological ...
Mishra Rajesh Kumar RK Tansna Therapeutics, Inc., 4320 Forest Park Avenue, St. Louis, MO 63108, United States. Electronic address: - - 2014
The natural compounds carvacrol and thymol completely prevented seizures in the 6Hz, 32mA partial seizure model. Carvacrol and thymol, both exhibited an ED50=35.8mg/kg, ip and yielded protective indices of 5.3 and 3.4, respectively. At 44mA current intensity, carvacrol and thymol exhibited ED50s of 88.82mg/kg (PI=2.15) and 73.0mg/kg (PI=1.65), respectively. Thymol, ...
Bignami Fabio F Division of Neuroscience, Eye Repair Lab, San Raffaele Scientific Institute, Via Olgettina 60, Milan, 20132, - - 2014
Purpose. To determine whether the inhibition of Substance P (SP) activity can reduce corneal neovascularization (CNV) by means of local administration of high-affinity, competitive, tachykinin 1 receptor (NK1R) antagonists Lanepitant and Befetupitant. Methods. We performed a safety and efficacy study using: (i) two different C57BL/6 mouse models of CNV: alkali ...
Li Xuwu X From the Chongqing University of Science and Technology, Chongqing, - - 2014
This study aims to determine the measured accurate value of space movement distance of tooth in the process of orthodontic treatment, thereby contributing to the selection of clinical appliance treatment. We obtained the point cloud data of all stages model by the 3D scanning equipment. Through the coordinate matching for ...
Kamisetty Supradeep Kumar SK Reader, Department of Orthodontics and Dentofacial Orthopaedics, St. Joseph Dental College , Duggirala, Eluru, Andhra Pradesh, India - - 2014
Evaluations on retraction loop designs have been limited to describe the force systems applied to the buccal surfaces of the tooth that can be in different planes resulting undesirable effects, needing corrective action in future. By initially understanding these effects, modifications to the loop design can essentially counteract the undesired ...
Correia Gabriele Dória Cabral - - 2014
Technological advances in Dentistry have emerged primarily in the area of diagnostic tools. One example is the 3D scanner, which can transform plaster models into three-dimensional digital models. This study aimed to assess the reliability of tooth size-arch length discrepancy analysis measurements performed on three-dimensional digital models, and compare these ...
Hasija Narender N Professor, Department of Pedodontics, JCD Dental College, Sirsa Haryana, - - 2014
Regards and Tribute: Late Dr Narender Hasija was a mentor and visionary in the light of knowledge and experience. We pay our regards with deepest gratitude to the departed soul to rest in peace. Bolton's ratios help in estimating overbite, overjet relationships, the effects of contemplated extractions on posterior occlusion, ...
Konttila Teijo T Department of Biomedical Engineering and Computational Science, Aalto University, Espoo, - - 2014
In the electrocardiographic (ECG) inverse problem, the electrical activity of the heart is estimated from measured electrocardiogram. A model of thorax conductivities and a model of the cardiac generator is required for the ECG inverse problem. Limitations and errors in methods, models, and data will lead to errors in the ...
van Kuijk Annette Aa - - 2014
To explore if stimulus-response (S-R) characteristics of the silent period (SP) after transcranial magnetic stimulation (TMS) are affected by changing the SP definition and by changing data presentation in healthy individuals. This information would be clinically relevant to predict motor recovery in patients with stroke using stimulus-response curves. Different landmarks ...
Poormohammadi Hadi H School of Biological Sciences, Institute for Research in Fundamental Sciences (IPM), Tehran, - - 2014
The problem of constructing an optimal rooted phylogenetic network from an arbitrary set of rooted triplets is an NP-hard problem. In this paper, we present a heuristic algorithm called TripNet, which tries to construct a rooted phylogenetic network with the minimum number of reticulation nodes from an arbitrary set of ...
Na Sung Dae SD Department of Medical & Biological Engineering, Graduate School, Kyungpook National University, Daegu, Republic of - - 2014
In this paper, a new method for individual tooth segmentation was proposed. The proposed method is composed of enhancement and extraction of boundary and seed of watershed algorithm using trisection areas by morphological characteristic of teeth. The watershed algorithm is one of the conventional methods for tooth segmentation; however, the ...
Zhang Chao C Institut für Mineralogie, Leibniz Universität Hannover, 30167 Hannover, - - 2014
Axial melt lenses sandwiched between the lower oceanic crust and the sheeted dike sequences at fast-spreading mid-ocean ridges are assumed to be the major magma source of oceanic crust accretion. According to the widely discussed "gabbro glacier" model, the formation of the lower oceanic crust requires efficient cooling of the ...
Cavas-Martínez Francisco F Department of Graphical Expression, Technical University of Cartagena, Cartagena, - - 2014
To establish a new procedure for 3D geometric reconstruction of the human cornea to obtain a solid model that represents a personalized and in vivo morphology of both the anterior and posterior corneal surfaces. This model is later analyzed to obtain geometric variables enabling the characterization of the corneal geometry ...
Kather Jakob Nikolas JN Department of Vascular Biology and Tumor Angiogenesis, Center for Biomedicine and Medical Technology Mannheim (CBTM), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany and Division of Vascular Oncology and Metastasis, German Cancer Research Center (DKFZ-ZMBH Alliance), Heidelberg, - - 2014
Corneal neovascularization (NV) refers to the growth of blood vessels and/or lymphatics into the physiologically avascular cornea, which occurs in several pathological processes. In mouse models, corneal NV can be artificially induced to investigate mechanisms of corneal pathologies. However, mouse models of corneal NV are not restricted to cornea-specific research, ...
Cacciatore Stefano - - 2013
Metabolomic profiles of tissues could greatly contribute to advancements in personalized medicine but are influenced by differences in adopted pre-analytical procedures; non homogeneous pre- and post-excision ischemia times are potential sources of variability. In this study we monitored the impact of ischemia on the metabolic profiles, acquired with high-resolution magic-angle-spinning ...
Wang Dafang - - 2013
With the goal of non-invasively localizing cardiac ischemic disease using body-surface potential recordings, we attempted to reconstruct the transmembrane potential (TMP) throughout the myocardium with the bidomain heart model. The task is an inverse source problem governed by partial differential equations (PDE). Our main contribution is solving the inverse problem ...
Jennekens Ward - - 2013
The aim of this study was to evaluate EEG source localization by standardized weighted low-resolution brain electromagnetic tomography (swLORETA) for monitoring of fullterm newborns with hypoxic-ischemic encephalopathy, using a standard anatomic head model. Three representative examples of neonatal hypoxic-ischemia were included. The method was validated with MRI data. Hypoxic-ischemic areas, ...
Wand Michael - - 2013
An electromygraphic (EMG) Silent Speech Interface is a system which recognizes speech by capturing the electric potentials of the human articulatory muscles, thus enabling the user to communicate silently. This study deals with improving the EMG signal quality by removing artifacts: The EMG signals are captured by electrode arrays with ...
Ercus Sebastian S Post-Graduate Student, Esthetic Program, UCLA Center for Esthetic Dentistry, Los Angeles, California. Owner, Dental Specialty Center Brussels, Ixelles, - - 2013
In both the clinical and dental laboratory environments, computer-assisted technology along with new materials are leading to a paradigm shift in what many practitioners regard as standard of care for patients. The case described uses digital solutions for smile design, patient communication, minimal tooth preparation, scanning, digitally generated models, and ...
Boerlijst Maarten C - - 2013
Catastrophic and sudden collapses of ecosystems are sometimes preceded by early warning signals that potentially could be used to predict and prevent a forthcoming catastrophe. Universality of these early warning signals has been proposed, but no formal proof has been provided. Here, we show that in relatively simple ecological models ...
Zinkel John L - - 2012
BACKGROUND:: Rat brain perfusion models are critical to basic research, but they can be imprecise and/or not durable for extended outcome studies. OBJECTIVE:: To demonstrate a rat brain perfusion model that provides a simplified reliable brain perfusion circuit, reduces variables during experiment and recovery, and therefore, permits more precise, reliable, ...
Easton Graham - - 2012
To discover which models for teaching physical examination skills have been proposed, and to appraise the evidence for each. We conducted a narrative review of relevant literature from 1990-2010. We searched the databases MEDLINE, PsycINFO, and ERIC (The Education Resource Information Centre) for the terms: 'physical examination' AND 'teaching' as ...
Riboni Francesca - - 2012
PURPOSE: The aim of this multicentric study is to compare clinical, biophysical and molecular parameters in the prediction of the success of labour induction with prostaglandins. METHODS: We included 115 women, who underwent to labour induction at term with vaginal prostaglandin gel. We evaluated the diagnostic efficiency of endocervical phosphorylated ...
Dittrich Anna - - 2012
Misregulated interleukin-6 (IL-6)-induced Jak/STAT signaling contributes to many diseases. Under non-pathological conditions Jak/STAT signaling is tightly regulated by a complex network of regulators. One of these regulators is the protein tyrosine phosphatase SH2-containing phosphatase 2 (SHP2). Although SHP2 is known to be a negative regulator of IL-6-induced Jak/STAT signaling, its ...
Wollersheim Sonja - - 2012
Cardiopulmonary bypass (CPB) has been known to induce an inflammatory response that is influenced by various factors. Hypothermia is supposed to reduce inflammation after CPB. We developed an in vitro coculture model for CPB and compared the effects of hypothermia on the inflammatory response in the coculture model with results ...
Antó Josep M - - 2012
Mechanisms of the Development of Allergy (MeDALL), a Seventh Framework Program European Union project, aims to generate novel knowledge on the mechanisms of initiation of allergy. Precise phenotypes of IgE-mediated allergic diseases will be defined in MeDALL. As part of MeDALL, a scientific seminar was held on January 24, 2011, ...
Marsella Rosanna - - 2012
Probiotics modulate the immune response and may have protective effects against atopic dermatitis (AD). Clinical trials using dogs with spontaneous disease are limited by confounding factors such as different diets, environments and sensitizations while a more controlled evaluation is possible using experimental models. A validated model of canine AD showed ...
Benton T G - - 2012
The mapping of environment, through variation in individuals' life histories, to dynamics can be complex and often poorly known. Consequently, it is not clear how important it is dynamically. To explore this, I incorporated lessons from an empirical system, a soil mite, into an individual-based model. Individuals compete for resource ...
Witt Johannes - - 2012
Activation of nuclear factor κB (NF-κB) by interleukin-1β (IL-1) usually results in an anti-apoptotic activity that is rapidly terminated by a negative feedback loop involving NF-κB dependent resynthesis of its own inhibitor IκBα. However, apoptosis induced by ultraviolet B radiation (UVB) is not attenuated, but significantly enhanced by co-stimulation with ...
Paltrinieri Nicola - - 2011
The recent occurrence of severe major accidents has brought to light flaws and limitations of hazard identification (HAZID) processes performed for safety reports, as in the accidents at Toulouse (France) and Buncefield (UK), where the accident scenarios that occurred were not captured by HAZID techniques. This study focuses on this ...
Skripuletz T - - 2011
The copper chelator cuprizone (bis-cyclohexanone oxaldihydrazone) was established as a neurotoxin in rodents in 1966 by Carlton. During the following years the usefulness of cuprizone feeding in mice to induce oligodendrocyte death with secondary demyelination of the superior cerebellar peduncles was described by Blakemore. In 1998 the cuprizone model experienced ...
Dogan S A - - 2011
Understanding mitochondrial role in normal physiology and pathological conditions has proven to be of high importance as mitochondrial dysfunction is connected with a number of disorders as well as some of the most common diseases (e.g. diabetes or Parkinson's disease). Modeling mitochondrial dysfunction has been difficult mainly due to unique ...
Wamsler Christine - - 2011
Climate change and disasters pose a serious risk to sustainable development. In the South, local coping strategies are an important element of adaptation to climate and disaster risk. Such strategies have emerged because of the limited assistance provided by urban actors and associated social security and governance systems. In the ...
Meyer Jens Eduard - - 2011
Ultrasound investigations for the correct identification of lymph node metastases depend on the experience and qualifications of the investigator; thus, model that provides better preoperative evaluation is desired. Data from 290 patients with an upcoming neck dissection were analyzed to compare the preoperative ultrasound assessment of neck metastases with the ...
Czövek András - - 2011
Conventional kinesin is a two-headed homodimeric motor protein, which is able to walk along microtubules processively by hydrolyzing ATP. Its neck linkers, which connect the two motor domains and can undergo a docking/undocking transition, are widely believed to play the key role in the coordination of the chemical cycles of ...
McKee Clayton T CT Department of Surgical and Radiological Science, School of Veterinary Medicine, University of California Davis, Davis, California 95616, - - 2011
In this review, we compare the reported values of Young's modulus (YM) obtained from indentation and tensile deformations of soft biological tissues. When the method of deformation is ignored, YM values for any given tissue typically span several orders of magnitude. If the method of deformation is considered, then a ...
Kapoor Tanya - - 2011
This research focuses on an investigation into the head and neck injuries sustained by toddlers due to CRS misuse under frontal and side impact crashes. A fully deformable FE model incorporating a Hybrid III 3-year-old dummy was developed which has been previously validated for frontal impacts under CMVSS 208 and ...
Rahmatalla Salam - - 2011
It seems obvious that human head-neck posture in whole-body vibration (WBV) contributes to discomfort and injury risk. While current mechanical measures such as transmissibility have shown good correlation with the subjective-reported discomfort, they showed difficulties in predicting discomfort for non-neutral postures. A new biomechanically based methodology is introduced in this ...
Moorcroft Robyn L - - 2011
We study numerically the formation of long-lived transient shear bands during shear startup within two models of soft glasses (a simple fluidity model and an adapted "soft glassy rheology" model). The degree and duration of banding depends strongly on the applied shear rate, and on sample age before shearing. In ...
Chen Si - - 2011
Prediction of soft tissue aesthetics is important for achieving an optimal outcome in orthodontic treatment planning. Previously, applicable procedures were mainly restricted to 2-D profile prediction. In this study, a generic 3-D finite element (FE) model of the craniofacial soft and hard tissue was constructed, and individualisation of the generic ...
Sangpradit Kiattisak K Faculty of Engineering, Rajamangala University of Technology Thunyaburi, Pathum Thani 12110, Thailand. - - 2011
We describe a finite-element (FE) model for simulating wheel-rolling tissue deformations using a rolling FE model (RFEM). A wheeled probe performing rolling tissue indentation has proven to be a promising approach for compensating for the loss of haptic and tactile feedback experienced during robotic-assisted minimally invasive surgery (H. Liu, D. ...
Yan Wenyi - - 2011
A recently published finite element (FE) head model is modified to consider the viscoelasticity of the meninges, the spongy and compact bone in the skull. The cerebrospinal fluid (CSF) is simulated explicitly as a hydrostatic fluid by using a surface-based fluid modelling method, which allows fluid and structure interaction. It ...
Malony Allen D - - 2011
Understanding the milliscale (temporal and spatial) dynamics of the human brain activity requires high-resolution modeling of head electromagnetics and source localization of EEG data. We have developed an automated environment to construct individualized computational head models from image segmentation and to estimate conductivity parameters using electrical impedance tomography methods. Algorithms ...
Grimm Dirk - - 2011
For the past five years, evidence has accumulated that vector-mediated robust RNA interference (RNAi) expression can trigger severe side effects in small and large animals, from cytotoxicity and accelerated tumorigenesis to organ failure and death. The recurring notions in these studies that a critical parameter is the strength of RNAi ...
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