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Shetye Snehal S SS Department of Mechanical Engineering, Colorado State University, Fort Collins, CO, - - 2014
The dura mater performs a major functional role in the stability and mechanical response of the spinal cord complex. Computational techniques investigating the etiology of spinal cord injury require an accurate mechanical description of the dura mater. Previous studies investigating the mechanical response of the dura mater have reported conflicting ...
Degenhardt Louisa L National Drug and Alcohol Research Centre, University of New South Wales, 2052, Australia; Melbourne School of Population and Global Health, University of Melbourne, 3053, Australia. Electronic address: - - 2014
To estimate the global prevalence of cocaine and amphetamine dependence and the burden of disease attributable to these disorders. An epidemiological model was developed using DisMod-MR, a Bayesian meta-regression tool, using epidemiological data (prevalence, incidence, remission and mortality) sourced from a multi-stage systematic review of data. Age, sex and region-specific ...
Wilson Amy A School of Mathematics and Maxwell Institute, University of Edinburgh, Mayfield Road, Edinburgh EH9 3JZ, United - - 2014
Banknotes can be seized from crime scenes as evidence for suspected association with illicit drug dealing. Tandem mass spectrometry data are available from banknotes seized in criminal investigations, as well as from banknotes from general circulation. The aim of the research is to evaluate the support provided by the data ...
Bisceglia Kevin J KJ Department of Geography and Environmental Engineering, Johns Hopkins University, 3400 North Charles Street, Baltimore, MD, 21218, USA, - - 2013
Transformations of cocaine and eleven of its metabolites were investigated in untreated municipal sewage at pH ≈ 7 and 9, 23, and 31 °C. Results indicated that hydrolysis-possibly bacterially mediated-was the principal transformation pathway. Residues possessing alkyl esters were particularly susceptible to hydrolysis, with pseudo-first-order rate constants varying from 0.54 to 1.7 day(-1) at ...
Zuzzi Sara - - 2013
A comparative analysis of three different estimation methods of cocaine use in Milan, Italy, is carried out, including an analysis of the size and trends of the underlying reference population. The three cocaine use estimates are derived from wastewater analysis, a "street" survey and one-source capture-recapture analysis of administrative sanctions ...
Cao Peng P Department of Orthopedics, Rui-Jin Hospital, School of Medicine, Shanghai Jiao-tong University, Institute of Trauma and Orthopedics, Shanghai 200025, - - 2013
Research into spinal cord injury depends upon animal models of trauma. While investigations using small animals have yielded critical insights into the cellular mechanisms of neurotrauma, no effective therapies have been translated to human clinical treatments. There are considerable differences in pathophysiology, scale, and anatomical organization between rodents and primates. ...
Zheng Fang - - 2013
Butyrylcholinesterase (BChE) has been an important protein used for development of anti-cocaine medication. Through computational design, BChE mutants with ∼2000-fold improved catalytic efficiency against cocaine have been discovered in our lab. To study drug-enzyme interaction it is important to build mathematical model to predict molecular inhibitory activity against BChE. This ...
Schwab Frank - - 2013
Global sagittal malalignment is significantly correlated with health related quality of life scores in the setting of spinal deformity. In order to address rigid deformity patterns, the use of spinal osteotomies has seen a substantial increase. Unfortunately, variations of established techniques and hybrid combinations of osteotomies have made comparisons of ...
Arle Jeffrey E - - 2013
The purpose of this study was to examine how scar formation may affect electrical current distribution in the spinal cord when using paddle leads placed in the epidural space during treatment with spinal cord stimulation. A finite element model of the spinal cord was used to examine changes in stimulation ...
Wisner Krista M - - 2013
Abstract Background: Addiction is a complex phenotype, though it consistently includes characteristics of impulsivity. A number of brain regions are suggested to be involved in cocaine addiction, including the insula, which serves diverse functions including interoceptive awareness and integration of neural signals from sensory, subcortical and frontal regions. Malfunction of ...
Lamanna Jason J - - 2013
Current literature demonstrates the efficacy of cell-based therapeutics in small animal models of varied spinal cord diseases. However, logistic challenges remain towards development of an optimized delivery approach to the human spinal cord. Clinical trials utilize a variety of methods to achieve this aim. In this article, the authors review ...
Sankarasubramanian Vishwanath - - 2013
In spinal cord stimulation, anodes tend to have a strong effect over the area of dorsal column (DC) activation, when configured as both longitudinal guarded cathodes (LGCs) and transverse tripoles (TTs). Inclusion of a small spacing step (LGC+) in the center-center (C-C) spacing of the LGC can be an efficient ...
Samson R S - - 2013
The aim of this study was to quantify a range of MR parameters [apparent proton density, longitudinal relaxation time T1 , magnetisation transfer (MT) ratio, MT saturation (which represents the additional percentage MT saturation of the longitudinal magnetisation caused by a single MT pulse) and apparent transverse relaxation rate R2 ...
Zhang Hong-Qi - - 2013
Object The authors undertook this study to establish an animal model to investigate the pathophysiological changes of venous hypertensive myelopathy (VHM). Methods This study was a randomized control animal study with blinded evaluation. The VHM model was developed in 24 adult New Zealand white rabbits by means of renal artery ...
Chen Roland - - 2013
The primary objective of our study was to develop a thermo-electrical model with both solid and liquid phases to calculate tissue temperature during bipolar coagulation of a posterior spinal artery on the spinal cord. Control of thermal spread caused by coagulation is a concern in spinal surgery. This model utilizes ...
Lehtinen Jaakko - - 2013
In this study, a novel approach combining different techniques, including Fourier transform infrared (FT-IR) spectroscopy, photoacoustic spectroscopy (PAS) with an interferometric cantilever microphone, and principal component analysis (PCA) along with a proper data preprocessing procedure, have been used in the investigation of hair samples for cocaine abuse. Hair fibers from ...
Chen Roland K - - 2013
This study develops a new class of gellan gum-based tissue-mimicking phantom material and a model to predict and control the elastic modulus, thermal conductivity, and electrical conductivity by adjusting the mass fractions of gellan gum, propylene glycol, and sodium chloride, respectively. One of the advantages of gellan gum is its ...
Buckingham Gavin - - 2013
Observing the actions of others has been shown to modulate cortico-spinal excitability and affect behaviour. However, the sensorimotor consequences of observing errors are not well understood. Here, participants watched actors lift identically weighted large and small cubes which typically elicit expectation-based fingertip force errors. One group of participants observed the ...
Vijayaprakash K M KM Centre for Tissue Engineering and Regeneration, Frontier Mediville (Special Economic Zone), Frontier Lifeline Pvt Ltd., A Unit of Dr.KM.Cherian Heart Foundation, Elavoor, Gummidipoondi, Tamilnadu, - - 2013
Till date, NYU MASCIS (New York University, Multicenter Animal Spinal Cord Injury Study) impactor and Ohio State University electromagnetic spinal cord injury device impactor were under use for simulating an experimental spinal cord injury in rodents; functional recovery being assessed through Basso, Beattie and Bresnahan (BBB) scoring method which is ...
Lucantonio Federica - - 2013
Cocaine addiction is a complex and multidimensional process involving a number of behavioral and neural forms of plasticity. The behavioral transition from voluntary drug use to compulsive drug taking may be explained at the neural level by drug-induced changes in function or interaction between a flexible planning system, associated with ...
Mattei Tobias A - - 2013
Simulation has become an important tool in neurosurgical education as part of the complex process of improving residents' technical expertise while preserving patient safety. Although different simulators have already been designed for a variety of neurosurgical procedures, spine simulators are still in their infancy and, at present, there is no ...
Harrell Paul Truman PT Johns Hopkins Bloomberg School of Public Health, Department of Mental Health, Baltimore, MD 21295, USA. - - 2013
Motivation for treatment among people with substance use problems is an important aspect of treatment success. Models for treatment motivation are widely debated. Latent Class Analysis can help to demonstrate the appropriateness of available models. The current study utilizes Latent Class Analysis to analyze treatment readiness statements as they relate ...
Ding Xiaoyu - - 2013
Model order selection in group independent component analysis (ICA) has a significant effect on the obtained components. This study investigated the reproducible brain regions of abnormal default-mode network (DMN) functional connectivity related with cocaine addiction through different model order settings in group ICA. Resting-state fMRI data from 24 cocaine addicts ...
Derringer Jaime - - 2013
AIMS: To examine whether DSM-IV symptoms of substance dependence are psychometrically equivalent between existing community-sampled and clinically overselected studies. PARTICIPANTS: A total of 2476 adult twins born in Minnesota and 4121 unrelated adult participants from a case-control study of alcohol dependence. MEASUREMENTS: Life-time DSM-IV alcohol, marijuana and cocaine dependence symptoms ...
Borders Tyrone F - - 2013
ABSTRACT. Objective: Little is known about whether cocaine or methamphetamine use, particularly among stimulant users residing in rural areas, is associated with increased odds of developing or maintaining an alcohol use disorder (AUD) over time. One factor that may help to protect some users against the development of an AUD ...
Hanlon Colleen A - - 2013
Cocaine remains one of the most addictive substances of abuse and one of the most difficult to treat. Although increasingly sophisticated experimental and technologic advancements in the last several decades have yielded a large body of clinical and preclinical knowledge on the direct effects of cocaine on the brain, we ...
Lee Jennifer Pai - - 2013
A new method of estimating drug clearance in patients with spinal cord injury (SCI) was tested against other methods through a retrospective analysis of its predictive ability in estimating vancomycin clearance. A retrospective chart-based investigation was conducted at a hospital with a large SCI population. Using data collected from electronic ...
Yampolsky M - - 2013
INTRODUCTION: While the mean shape of human placenta is round [1] with centrally inserted umbilical cord, significant deviations from this ideal are fairly common, and may be clinically meaningful [1]. Traditionally, they are explained by trophotropism. We have proposed a hypothesis explaining typical variations in placental shape by randomly determined ...
Abbracchio Mariapia - - 2013
The paper deals with the discovery of non-adrenergic, non-cholinergic (NANC) purinergic neurotransmission, some 50 years ago, and the explosion of interest in this new class of transmitters in the subsequent decades. Because of the very high interest of the topic, we felt it important to point out that the paper ...
Batalla Albert - - 2013
INTRODUCTION: Screening of substance use may prove useful to prevent readmission after the first episode of psychosis. The aim of the present study was to evaluate the influence of drug use on readmission risk in a first-episode psychosis sample, and to determine whether the cannabis/cocaine subscale of the Dartmouth Assessment ...
Golhasani-Keshtan Farideh - - 2013
Abstract Objective: To test the psychometric specifications of the Persian version of the Craig Handicap Assessment and Reporting Technique (CHART) short form in an Iranian population. Design: Cross-sectional study. Subjects: Fifty-two individuals with a mean age of 49.3 years (SD 7.9, minimum 38 years and maximum 80 years), who had ...
Lee B B - - 2013
Study design:Literature review.Objectives:Update the global maps for traumatic spinal cord injury (TSCI) and incorporate methods for extrapolating incidence data.Setting:An initiative of the International Spinal Cord Society (ISCoS) Prevention Committee.Methods:A search of Medline/Embase was performed (1959-Jun/30/2011). Enhancement of data-quality 'zones' including individual data-ranking as well as integrating regression techniques to provide ...
Plósz Benedek Gy - - 2013
The quantitative analysis of human urinary metabolites as biomarkers in wastewater streams has been used to estimate the rates of illicit drug use in the wider community. The primary underlying assumption in such studies is that a sample of wastewater is equivalent to a cumulative sample of urine. Drug metabolism ...
Rouleau Pascal - - 2013
Most animal models of contused, compressed or transected spinal cord injury (SCI) require a laminectomy to be performed. However, despite advantages and disadvantages associated with each of these models, the laminectomy itself is generally associated with significant problems including longer surgery and anaesthesia (related post-operative complications), neuropathic pain, spinal instabilities, ...
Zacca Jorge Jardim - - 2013
Cocaine sample correlation provides important information in the identification of traffic networks. However, available methods for estimating if samples are linked or not require the use of previous police investigation and forensic expert knowledge regarding the number of classes and provide thresholds that are both static and dataset specific. In ...
New P W - - 2013
Study design:Multifaceted: extensive discussions at workshop and conference presentations, survey of experts and feedback.Objectives:Present the background, purpose and development of the International Spinal Cord Injury (SCI) Data Sets for Non-Traumatic SCI (NTSCI), including a hierarchical classification of aetiology.Setting:International.Methods:Consultation via e-mail, presentations and discussions at ISCoS conferences (2006-2009), and workshop (1 ...
Malgor R D - - 2013
Venous thromboembolism is one of the most common causes of morbidity and mortality in modern societies. The entirety of events involved in venous thrombus formation and resolution remains to be elucidated. Temporal relation between the initial cellular insult, thrombus formation and resolution is critical for instituting a prompt treatment. This ...
Ernst Markus J - - 2013
Accurate measurements of spinal movement require reliable determination of anatomical landmarks. Current methods of identifying these are not sufficiently reliable or valid for this purpose. A reliable and convenient method of placing markers on selected vertebra is needed to compare measurements between different testers, subjects and sessions. Two testers palpated ...
Driscoll Mark - - 2013
A large spectrum of medical devices exists; it aims to correct deformities associated with spinal disorders. The development of a detailed volumetric finite element model of the osteoligamentous spine would serve as a valuable tool to assess, compare, and optimize spinal devices. Thus the purpose of the study was to ...
Noël Xavier X Psychological Medicine Laboratory, Faculty of Medicine, Université Libre de Bruxelles , Brussels , - - 2013
According to the triadic neurocognitive model of addiction to drugs (e.g., cocaine) and non-drugs (e.g., gambling), weakened "willpower" associated with these behaviors is the product of an abnormal functioning in one or more of three key neural and cognitive systems: (1) an amygdala-striatum dependent system mediating automatic, habitual, and salient ...
Gibson-Corley Katherine N - - 2012
ABSTRACT Background: To improve methods for the treatment of intractable pain, we are developing a novel intradural spinal cord stimulator that could be either attached to the dentate ligaments of the human spinal cord or fitted around the dorsal arc of the cord itself. Purpose: Our goal was to carry ...
Ma Lijun - - 2012
Spinal cord biologically effective dose (BED) limits are critical to safe spine stereotactic body radiotherapy (SBRT) delivery. In particular, when repeating SBRT to the same site, the problem of adding non-uniform BED distributions within small volumes of spinal cord has yet to be solved. We report a probability-based generalized BED ...
Bender Edward T - - 2012
Purpose: To derive a radiobiological model that enables the estimation of brain necrosis and spinal cord myelopathy rates for a variety of fractionation schemes, and to compare repair effects between brain and spinal cord.Methods: Sigmoidal dose response relationships for brain radiation necrosis and spinal cord myelopathy are derived from clinical ...
Wang Xinlei X Department of Statistical Science, Southern Methodist University, Dallas, TX 75275, - - 2013
Epigenetics is the study of changes to the genome that can switch genes on or off and determine which proteins are transcribed without altering the DNA sequence. Recently, epigenetic changes have been linked to the development and progression of disease such as psychiatric disorders. High-throughput epigenetic experiments have enabled researchers ...
Charlton Shawn R - - 2012
The temporal discounting literature has demonstrated that the loss in value for delayed outcomes is most accurately modeled using a hyperbolic discounting equation. The hyperbolic-shaped function not only describes the shape of discounting for monetary outcomes, but also for other tangibles, such as alcohol, candy, CDs, erotica, cigarettes, cocaine, books, ...
Seoud L - - 2012
Besides the spinal deformity, scoliosis modifies notably the general appearance of the trunk resulting in trunk rotation, imbalance and asymmetries which constitutes patients' major concern. Existing classifications of scoliosis, based on the type of spinal curve as depicted on radiographs, are currently used to guide treatment strategies. Unfortunately, even though ...
Han Kap-Soo - - 2012
Knowledge about spinal loading is required for designing and preclinical testing of spinal implants. It is assumed that loading of the spine depends upon body weight and height, as well as on the spine level, but a direct measurement of the loading conditions throughout the spine is not yet possible. ...
Filli Linard - - 2012
Over the past 2 decades, the biological understanding of the mechanisms underlying structural and functional repair of the injured central nervous system has strongly increased. This has resulted in the development of multiple experimental treatment strategies with the collective aim of enhancing and surpassing the limited spontaneous recovery occurring in ...
Biering-Sørensen F - - 2012
Objectives:To develop an International Spinal Cord Injury (SCI) Musculoskeletal Basic Data Set as part of the International SCI Data Sets to facilitate consistent collection and reporting of basic musculoskeletal findings in the SCI population.Setting:International.Methods:A first draft of an SCI Musculoskeletal Basic Data Set was developed by an international working group. ...
Sartori Massimo - - 2012
In this paper, we use motion capture technology together with an EMG-driven musculoskeletal model of the knee joint to predict muscle behavior during human dynamic movements. We propose a muscle model based on infinitely stiff tendons and show this allows speeding up 250 times the computation of muscle force and ...
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