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Sacchi Lucia L Dipartimento di Ingegneria Industriale e dell'Informazione, Università degli Studi di Pavia, Via Ferrata 1, Pavia, 27100, Italy, - - 2015
In recent years, data coming from hospital information systems (HIS) and local healthcare organizations have started to be intensively used for research purposes. This rising amount of available data allows reconstructing the compete histories of the patients, which have a strong temporal component. This chapter introduces the major challenges faced ...
Lobaugh Megan L ML *University of Cincinnati, Nuclear and Radiological Engineering Program, 598 Rhodes Hall, Cincinnati, OH 45221-0072; †Currently at Lawrence Livermore National Laboratory, Livermore, CA - - 2015
Radioactive material deposited in multiple organs of the body is likely to confound a result of an in vivo measurement performed over the lungs, the most frequently monitored organ for occupational exposure. The significance of this interference was evaluated by measuring anthropometric torso phantoms containing lungs, liver, skeleton, and axillary ...
Guidolin Diego D Department of Molecular Medicine, Section of Anatomy, University of Padova, via Gabelli 65, 35121, Padova, Italy, - - 2015
In vitro assays that stimulate the formation of capillary-like structures by EC have become increasingly popular, because they allow the study of the EC's intrinsic ability to self-organize to form vascular-like patterns. Here we describe a widely applied protocol involving the use of basement membrane matrix (Matrigel) as a suitable ...
Myers Chris C Dept. of Electrical and Computer Engineering, University of Utah, Salt Lake City, UT, - - 2015
The design and construction of engineered organisms is an emerging new discipline called synthetic biology and holds considerable promise as a new technological platform. The design of biologically engineered systems is however nontrivial, requiring contributions from a wide array of disciplines. One particular issue that confronts synthetic biologists is the ...
Mak Rachel R Department of Physics & Astronomy, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208, USA. - - 2014
X-Ray absorption spectromicroscopy provides rich information on the chemical organization of materials down to the nanoscale. However, interpretation of this information in studies of "natural" materials such as biological or environmental science specimens can be complicated by the complex mixtures of spectroscopically complicated materials present. We describe here the shortcomings ...
Kuwayama Toshihiro - - 2014
Primary organic aerosol (POA) emitted from light duty gasoline vehicles (LDGVs) exhibits a semi-volatile behavior in which heating the aerosol and / or diluting the aerosol leads to partial evaporation of the POA. A single volatility distribution can explain the median evaporation behavior of POA emitted from LDGVs but this ...
Swider Brian W - - 2014
Numerous studies link applicant fit perceptions measured at a single point in time to recruitment outcomes. Expanding upon this prior research by incorporating decision-making theory, this study examines how applicants develop these fit perceptions over the duration of the recruitment process, showing meaningful changes in fit perceptions across and within ...
Nandi Anjan K AK Centre for Ecological Sciences, Indian Institute of Science, Bangalore, Karnataka 560012, India - - 2014
Social insects provide an excellent platform to investigate flow of information in regulatory systems since their successful social organization is essentially achieved by effective information transfer through complex connectivity patterns among the colony members. Network representation of such behavioural interactions offers a powerful tool for structural as well as dynamical ...
Zaidan A A AA Department of Computing, Faculty of Arts, Computing and Creative Industry, Universiti Pendidikan Sultan Idris, Tanjong Malim, Perak, - - 2014
Evaluating and selecting software packages that meet the requirements of an organization are difficult aspects of software engineering process. Selecting the wrong open-source EMR software package can be costly and may adversely affect business processes and functioning of the organization. This study aims to evaluate and select open-source EMR software ...
Kim Byoungjin B Department of Chemical and Biomolecular Engineering (BK21 Plus Program), BioProcess Engineering Research Center, Bioinformatics Research Center, Center for Systems and Synthetic Biotechnology, Institute for the BioCentury, Korea Advanced Institute of Science and Technology (KAIST), 291 Daehak-ro, Yuseong-gu, Daejeon, 305-701, Republic of - - 2014
Genome-scale metabolic network model (GEM) is a fundamental framework in systems metabolic engineering. GEM is built upon extensive experimental data and literature information on gene annotation and function, metabolites and enzymes so that it contains all known metabolic reactions within an organism. Constraint-based analysis of GEM enables the identification of ...
Ryberg Wade A WA Department of Wildlife and Fisheries Sciences, Biodiversity Research and Teaching Collections, Texas A&M University, College Station, TX, 77843, U.S.A.; Texas A&M Institute of Renewable Natural Resources, 1500 Research Parkway, College Station, TX, 77843, - - 2014
Irreplaceable, self-organizing landforms and the endemic and ecologically specialized biodiversity they support are threatened globally by anthropogenic disturbances. Although the outcome of disrupting landforms is somewhat understood, little information exists that documents population consequences of landform disturbance on endemic biodiversity. Conservation strategies for species dependent upon landforms have been difficult ...
Bittermann Kai - - 2014
The partition coefficient of chemicals from water to phospholipid membrane, Klipw, is of central importance for various fields. For neutral organic molecules, log Klipw correlates with the log of bulk solvent-water partition coefficients such as the octanol-water partition coefficient. However, this is not the case for charged compounds, for which ...
Huang Kang K Key Laboratory of Resource Biology and Biotechnology in Western China of Ministry of Education, and College of Life Sciences, Northwest University, Xi'an, ShaanXi, China, - - 2014
Estimates of relatedness coefficients, based on genetic marker data, are often necessary for studies of genetics and ecology. While many estimates based on method-of-moment or maximum-likelihood methods exist for diploid organisms, no such estimators exist for organisms with multiple ploidy levels, which occur in some insect and plant species. Here, ...
Neves Laura A LA National Institute of Metrology, Quality and Technology -INMETRO, Division of Chemical Metrology, 25250-020, Duque de Caxias, RJ, Brazil, - - 2014
The Brazilian Metrology Institute (National Institute of Metrology, Quality, and Technology, Inmetro) has been developing a certified reference material (CRM) of the volatile organic compounds benzene; toluene; ethylbenzene; and ortho, meta, and para-xylenes (BTEX) in methanol, to ensure quality control for environmental-analysis measurements. The objective of this paper is to ...
Wilson Laura A B LA School of Biological, Earth and Environmental Sciences, University of New South Wales, Kensington, - - 2014
Keeping pace with the forward progression of evolutionary developmental studies and their trajectory toward ever-more integrative and broad-scale study presents a challenge for researchers from diverse disciplines. Increasing the capacity for discourse and opening opportunity to further interdisciplinary work is highly desirable, and one way that activities can be hindered ...
Biller Steven J SJ Department of Civil and Environmental Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, - - 2014
The marine cyanobacterium Prochlorococcus is the smallest and most abundant photosynthetic organism on Earth. In this Review, we summarize our understanding of the diversity of this remarkable phototroph and describe its role in ocean ecosystems. We discuss the importance of interactions of Prochlorococcus with the physical environment, with phages and ...
Lopes Cristina C IPMA, Instituto Português do Mar e da Atmosfera, 1749-077 Lisbon, Portugal; CIMAR, Centro de Investigação Marinha e Ambiental, Rua dos Bragas, 4050-123 Porto, Portugal; - - 2014
Understanding responses of oceanic primary productivity, carbon export, and burial to climate change is essential for model-based projection of biological feedbacks in a high-CO2 world. Here we compare estimates of productivity based on the composition of fossil diatom floras with organic carbon burial off Oregon in the Northeast Pacific across ...
Villeneuve Daniel L DL *US EPA Mid-Continent Ecology Division, 6201 Congdon Blvd, Duluth, Minnesota 55804, Environment Canada, Ecotoxicology and Wildlife Health Division, Ottawa, Ontario, K1A 0H3 Canada, Mississippi State University, Institute for Genomics, Biocomputing and Biotechnology, Starkville, Mississippi 39762, University of Saskatchewan, School of the Environment and Sustainability and Toxicology Centre, Saskatoon, Saskatchewan, SK S7N 5B3, Canada, University of Plymouth, School of Biological Sciences, Plymouth, Devon, PL4 8AA, UK, University of Minnesota, Water Resources Center, St. Paul, Minnesota 55108, European Commission, Joint Research Centre, Via E. Fermi 2749, 21027 Ispra, Italy, Department of Biology and Biochemistry, University of Houston, Houston, Texas, 77004, Zebrafishlab, Veterinary Physiology and Biochemistry, Department of Veterinary Sciences, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Belgium - - 2014
An adverse outcome pathway (AOP) is a conceptual framework that organizes existing knowledge concerning biologically plausible, and empirically supported, links between molecular-level perturbation of a biological system and an adverse outcome at a level of biological organization of regulatory relevance. Systematic organization of information into AOP frameworks has potential to ...
Villeneuve Daniel L DL *US EPA Mid-Continent Ecology Division, 6201 Congdon Blvd, Duluth, MN 55804, Environment Canada, Ecotoxicology and Wildlife Health Division, Ottawa, Ontario, Canada K1A 0H3, Institute for Genomics, Biocomputing and Biotechnology, Mississippi State University, Starkville, MS 39762, School of the Environment and Sustainability and Toxicology Centre, University of Saskatchewan, Saskatoon, Saskatchewan, Canada SK S7N 5B3, School of Biological Sciences, University of Plymouth, Plymouth, Devon, PL4 8AA, UK, Water Resources Center, University of Minnesota, St. Paul, MN 55108, European Commission, Joint Research Centre, Via E. Fermi 2749, 21027 Ispra, Italy, Department of Biology and Biochemistry, University of Houston, Houston, TX 77004, Zebrafishlab, Veterinary Physiology and Biochemistry, Department of Veterinary Sciences, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Belgium - - 2014
Organization of existing and emerging toxicological knowledge into adverse outcome pathway (AOP) descriptions can facilitate greater application of mechanistic data, including those derived through high-throughput in vitro, high content omics and imaging, and biomarker approaches, in risk-based decision making. The previously ad hoc process of AOP development is being formalized ...
Denes Jeremy J Agrocampus Ouest, UMR1069 Sol Agro et hydrosystème Spatialisation, F-35000 Rennes, France; INRA, UMR1069 Sol Agro et hydrosystème Spatialisation, F-35000 Rennes, France; Irstea, UR GERE, 17 avenue de Cucillé, CS 64427, F-35044 Rennes Cedex, France; Université Européenne de Bretagne, France. Electronic address: - - 2014
Composting wastes permits the reuse of organic matter (OM) as agricultural amendments. The fate of OM during composting and the subsequent degradation of composts in soils largely depend on waste OM quality. The proposed study aimed at developing a model to predict the evolution in organic matter quality during the ...
Lebacq T T 1Earth and Life Institute,Université catholique de Louvain,Croix du Sud 2, L7.05.14,1348 - - 2014
Increasing input self-sufficiency is often viewed as a target to improve sustainability of dairy farms. However, few studies have specifically analysed input self-sufficiency, by including several technical inputs and without only focussing on animal feeding, in order to explore its impact on farm sustainability. To address this gap, our work ...
Schofield Guy G Department of Surgery and Cancer, Imperial College London - - 2014
For most of human history there has been no particular importance of establishing the exact time of a person's death, only whether the person is alive or dead. With modern medical advances however more precise answers are looked for. For a definition of death to succeed is important that it ...
Gallardo A A Dept. Mechanical Engineering and Construction, Jaume I University, Av. de Vicent Sos Baynat s/n, 12071 Castelló de la Plana, Spain. Electronic address: - - 2014
The municipal solid waste (MSW) management is an important task that local governments as well as private companies must take into account to protect human health, the environment and to preserve natural resources. To design an adequate MSW management plan the first step consists in defining the waste generation and ...
Odijk Mathieu M BIOS/Lab-on-Chip Group, MESA+ Institute for Nanotechnology & MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, P. O. Box 217, 7500 AE Enschede, The Netherlands. - - 2014
Trans-epithelial electrical resistance (TEER) measurements are widely used as real-time, non-destructive, and label-free measurements of epithelial and endothelial barrier function. TEER measurements are ideal for characterizing tissue barrier function in organs-on-chip studies for drug testing and investigation of human disease models; however, published reports using this technique have reported highly ...
Viceconti Marco M Insigneo Institute for In Silico Medicine, University of Sheffield, Room F17, F floor, Pam Liversidge Building, Mappin Street, Sheffield S1 3JD, UK; VPH Institute for Biomedical Integrative Research, Belgium. Electronic address: - - 2014
In this perspective article we discuss the role of contemporary biomechanics in the light of recent applications such as the development of the so-called Virtual Physiological Human technologies for physiology-based in silico medicine. In order to build Virtual Physiological Human (VPH) models, computer models that capture and integrate the complex ...
Chatr-Aryamontri Andrew A Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, Quebec H3C 3J7, - - 2014
The Biological General Repository for Interaction Datasets (BioGRID: http://thebiogrid.org) is an open access database that houses genetic and protein interactions curated from the primary biomedical literature for all major model organism species and humans. As of September 2014, the BioGRID contains 749 912 interactions as drawn from 43 149 publications ...
Pyron Alexander R AR Department of Biological Sciences, The George Washington University, 2023 G Street NW, Washington, DC, 20052, - - 2014
Phylogenetic niche conservatism (PNC) typically refers to the tendency of closely related species to be more similar to each other in terms of niche than they are to more distant relatives. This has been implicated as a potential driving force in speciation and other species-richness patterns, such as latitudinal gradients. ...
Ruedig Elizabeth E Colorado State University, Department of Environmental & Radiological Health Sciences, Fort Collins, CO 80523, USA. Electronic address: - - 2014
Non-human biota dosimetry has historically relied on ellipsoidal dosimetric phantoms. In 2008, the International Commission on Radiological Protection (ICRP) presented a set of ellipsoidal models representative of wildlife, including dosimetric data for homogeneously distributed internal radionuclide sources. Such data makes it possible to quickly and easily estimate radiation dose rate. ...
Farley Kevin J KJ Department of Civil and Environmental Engineering, Manhattan College, Riverdale, New York, - - 2014
As part of the Metal Mixture Modeling Evaluation (MMME) project, models were developed by the National Institute of Advanced Industrial Science and Technology (Japan), the U.S. Geological Survey (USA), HDR׀HydroQual, Inc. (USA), and the Centre for Ecology and Hydrology (UK) to address the effects of metal mixtures on biological responses ...
Veltman Karin - - 2014
ToxicoKinetic ToxicoDynamic (TKTD) models are considered essential tools to further advance acute toxicity prediction of metals for a range of species and exposure conditions, but they are currently underutilized. We present a mechanistic TKTD model for acute toxicity prediction of silver (Ag) in freshwater organisms. In this new approach, we ...
Jones Graham G Department of Biological and Environmental Sciences, University of Gothenburg, Box 461, SE 405 30 Göteborg, - - 2014
The multispecies coalescent model provides a formal framework for the assignment of individual organisms to species, where the species are modeled as the branches of the species tree. None of the available approaches so far have simultaneously co-estimated all the relevant parameters in the model, without restricting the parameter space ...
Yibar Artun A Department of Food Hygiene and Technology, Faculty of Veterinary Medicine, Uludag University, 16059 Gorukle Campus, Bursa, Turkey. Electronic address: - - 2014
An abattoir survey was conducted from July 2012 to December 2012 to determine the major causes of organ and carcass condemnation and to estimate the associated direct financial loss at two abattoirs in Bursa Province in Turkey. A total of 22,872 sheeps and 5363 cattle were examined by postmortem inspection ...
Marcatili S S UMR 1037 INSERM-Centre de Recherche en Cancérologie de Toulouse, Toulouse, - - 2014
The accuracy of radiopharmaceutical absorbed dose distributions computed through Monte Carlo (MC) simulations is mostly limited by the low spatial resolution of 3D imaging techniques used to define the simulation geometry. This issue also persists with the implementation of realistic hybrid models built using polygonal mesh and/or NURBS as they ...
Gomez Laura E LE University of Oviedo, Department of Psychology, Plaza Feijoo, s/n., 33003 Oviedo, Spain. Electronic address: - - 2014
This paper documents the validation of a comprehensive scale designed to assess quality-of-life related personal outcomes for people with intellectual and developmental disabilities who receive support in social organizations. The INICO-FEAPS Scale was administered to 1627 people whose ages ranged between 16 and 72 years old. The instrument comprises 72 ...
Kyoda Koji K Laboratory for Developmental Dynamics, RIKEN Quantitative Biology Center, Kobe 650-0047, - - 2014
Recent progress in live-cell imaging and modeling techniques has resulted in generation of a large amount of quantitative data (from experimental measurements and computer simulations) on spatiotemporal dynamics of biological objects such as molecules, cells and organisms. Although many research groups have independently dedicated their efforts to developing software tools ...
Madden Judith C JC School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Byrom St., Liverpool L3 3AF, UK - - 2014
There is a long history of using both in silico and in vitro methods to predict adverse effects in humans and environmental species where toxicity data are lacking. Currently, there is a great deal of interest in applying these methods to the development of so-called 'adverse outcome pathway' (AOP) constructs. ...
Koskella Britt B BioSciences, University of Exeter, Penryn Campus, Tremough, Cornwall, TR10 9EZ, UK. - - 2014
Explaining the generation and maintenance of biodiversity is a central aim of evolutionary biology. This requires the integration of studies focused on explaining within-population diversity through to the organization of biodiversity at the ecosystem level. The combination of such comparative studies in nature with those employing experimental evolution in the ...
Donoso-Bravo Andres A a Escuela de Ingeniería Bioquímica, Facultad de Ingeniería , Pontificia Universidad Católica de Valparaíso . General Cruz 34, Valparaíso , - - 2014
Abstract Two-phase anaerobic systems are being increasingly implemented for the treatment of both sewage sludge and organic fraction of municipal solid waste. Despite the good amount of mathematical models in anaerobic digestion, few have been applied in two phase systems. In this study, a three-reaction mechanistic model has been developed, ...
Neumaier P F-X PF German Aerospace Center, Institute of Optical Sensor Systems, Rutherfordstr. 2, 12489 Berlin, Germany. Philipp.Neumaier@dlr.de - - 2014
We describe a spectrometer consisting of a vector network analyzer, a gas absorption cell, and a quasi-optical bench that acquires terahertz spectra of gaseous substances and mixtures. We tested volatile organic compounds that are medical biomarkers or chemicals which can be found on the US Environment Protection Agency list of ...
Granato Daniel D RIKILT - Institute of Food Safety, Wageningen University and Research Centre, P.O. Box 230, 6700, AE, Wageningen, The Netherlands; Food Quality and Design Group, Wageningen University and Research Centre, P. O. Box 17, 6700, AA, Wageningen, The Netherlands; Departament of Food Engineering, State University of Ponta Grossa, Av. Carlos Cavalcanti, 4748, 84030-900, Ponta Grossa, - - 2014
Organic, biodynamic, and conventional purple grape juices (PGJ; n = 79) produced in Brazil and Europe were characterized by volatile organic compounds (m/z 20-160) measured by proton transfer reaction mass spectrometry (PTR-MS) and classification models were built using supervised statistical techniques. K-nearest neighbours (KNN) and soft independent modelling of class analogy (SIMCA) ...
Tadmor Eitan E Center for Scientific Computation and Mathematical Modeling, University of Maryland, College Park, MD 20742, USA Department of Mathematics, University of Maryland, College Park, MD 20742, USA Institute for Physical Science and Technology, University of Maryland, College Park, MD 20742, USA - - 2014
We study the large-time behaviour of Eulerian systems augmented with non-local alignment. Such systems arise as hydrodynamic descriptions of agent-based models for self-organized dynamics, e.g. Cucker & Smale (2007 IEEE Trans. Autom. Control 52, 852-862. (doi:10.1109/TAC.2007.895842)) and Motsch & Tadmor (2011 J. Stat. Phys. 144, 923-947. (doi:10.1007/s10955-011-0285-9)) models. We prove ...
Juhász Z Z Department of Complex Systems, Research Centre for Natural Sciences of the HAS, Budapest, - - 2014
The goal of this study is to show two new clustering and visualising techniques developed to find the most typical clusters of 18-dimensional Y chromosomal haplogroup frequency distributions of 90 Western Eurasian populations. The first technique called "self-organizing cloud (SOC)" is a vector-based self-learning method derived from the Self Organising ...
Duan Yuping - - 2014
An interactive surgical simulation system needs to meet three main requirements, speed, accuracy and stability. In this paper, we present a stable and accurate method for animating mass-spring systems in real-time. An integration scheme derived from explicit integration is used to obtain interactive realistic animation for a multi-object environment. We ...
Groh Ksenia J KJ Eawag, Swiss Federal Institute of Aquatic Science and Technology, 8600 Dübendorf, Switzerland; ETH Zürich, Department of Chemistry and Applied Biosciences, 8093 Zürich, Switzerland. Electronic address: - - 2014
To elucidate the effects of chemicals on populations of different species in the environment, efficient testing and modeling approaches are needed that consider multiple stressors and allow reliable extrapolation of responses across species. An adverse outcome pathway (AOP) is a concept that provides a framework for organizing knowledge about the ...
Speck-Planche Alejandro - - 2014
Nanomaterials have revolutionized modern science and technology due to their multiple applications in engineering, physics, chemistry, and biomedicine. Nevertheless, the use and manipulation of nanoparticles (NPs) can bring serious damages to living organisms and their ecosystems. For this reason, ecotoxicity and cytotoxicity assays are of special interest, in order to ...
Kimura Hiroshi H Institute of Industrial Science, the University of Tokyo, Tokyo, Japan Department of Mechanical Engineering, Tokai University, Kanagawa, Japan Core Research for Evolutionary Science and Technology (CREST), Japan Science and Technology Agency (JST), Tokyo, - - 2014
Testing of drug effects and cytotoxicity by using cultured cells has been widely performed as an alternative to animal testing. However, the estimation of pharmacokinetics by conventional cell-based assay methods is difficult because of the inability to evaluate multiorgan effects. An important challenge in the field is to mimic the ...
Meier Matthias S MS FiBL - Research Institute of Organic Agriculture, Ackerstrasse 113, P.O. Box 219, 5070 Frick, Switzerland. Electronic address: - - 2014
Comprehensive assessment tools are needed that reliably describe environmental impacts of different agricultural systems in order to develop sustainable high yielding agricultural production systems with minimal impacts on the environment. Today, Life Cycle Assessment (LCA) is increasingly used to assess and compare the environmental sustainability of agricultural products from conventional ...
Sutton N J NJ Ecology and Evolutionary Biology Department, The University of Tennessee, Knoxville, 569 Dabney Hall, 1416 Circle Drive, Knoxville, TN, 37996, - - 2014
Facing tight resource constraints, conservation organizations must allocate funds available for habitat protection as effectively as possible. Often, they combine spatially referenced economic and biodiversity data to prioritize land for protection. We tested how sensitive these prioritizations could be to differences in the spatial grain of these data by demonstrating ...
De Blasio Fabio Vittorio FV Centre for Ecological and Evolutionary Synthesis, Department of Biosciences, University of Oslo, PO Box 1066 Blindern, 0316 Oslo, Norway. Electronic address: - - 2014
There are strong propositions in the literature that abiotic factors override biotic drivers of diversity on time scales of the fossil record. In order to study the interaction of biotic and abiotic forces on long term changes, we devise a spatio-temporal discrete-time Markov process model of macroevolution featuring population formation, ...
Barbillon Pierre P AgroParisTech / UMR INRA MIA, F-75005 Paris, France; INRA, UMR 518, F-75005 Paris, France. Electronic address: - - 2014
Dynamic extinction colonisation models (also called contact processes) are widely studied in epidemiology and in metapopulation theory. Contacts are usually assumed to be possible only through a network of connected patches. This network accounts for a spatial landscape or a social organization of interactions. Thanks to social network literature, heterogeneous ...
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