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Skåra Torstein T Nofima, Muninbakken 9-13, Pb 6122, N-9291 Tromsø, Norway; BioTeC - Chemical and Biochemical Process Technology and Control, Department of Chemical Engineering, Katholieke Universiteit Leuven, Leuven, Belgium. Electronic address: - - 2014
Steam surface pasteurization is a promising decontamination technology for reducing pathogenic bacteria in different stages of food production. The effect of the artificial inoculation type and initial microbial load, however, has not been thoroughly assessed in the context of inactivation studies. In order to optimize the efficacy of the technology, ...
Chen Diane D Division of Adolescent Medicine, Ann & Robert H. Lurie Children's Hospital of Chicago, 225 East Chicago Avenue, Box 10B, Chicago, IL, 60611-2605, USA, - - 2014
Peer rejection and deviant peer affiliation are linked consistently to the development and maintenance of conduct problems. Two proposed models may account for longitudinal relations among these peer processes and conduct problems: the (a) sequential mediation model, in which peer rejection in childhood and deviant peer affiliation in adolescence mediate ...
Zapata Felipe F Department of Ecology and Evolutionary Biology, Brown University, Providence, RI 02906, USA - - 2014
Gastropods are a highly diverse clade of molluscs that includes many familiar animals, such as limpets, snails, slugs and sea slugs. It is one of the most abundant groups of animals in the sea and the only molluscan lineage that has successfully colonized land. Yet the relationships among and within ...
Saraf Sanatan S a Department of Mathematics and Statistics , University of Maryland Baltimore County , Baltimore , Maryland , - - 2014
For the statistical validation of surrogate endpoints, an alternative formulation is proposed for testing Prentice's fourth criterion, under a bivariate normal model. In such a set up, the criterion involves inference concerning an appropriate regression parameter, and the criterion holds if the regression parameter is zero. Testing such a null ...
Vyumvuhore Raoul R Université Paris-Sud, Faculty of Pharmacy, Group of Analytical Chemistry of Paris-Sud (GCAPS), 51100 Chatenay-Malabry, - - 2014
ABSTRACT. Dermatologists need to combine different clinically relevant characteristics for a better understanding of skin health. These characteristics are usually measured by different techniques, and some of them are highly time consuming. Therefore, a predicting model based on Raman spectroscopy and partial least square (PLS) regression was developed as a ...
Meng Deyuan - - 2014
Resiliency is one of the most critical objectives found in complex industrial applications today and designing control systems to provide resiliency is an open problem. This paper proposes resilient control design guidelines for industrial systems that can be modeled as networked multiagent consensus systems subject to disturbances or noise. We ...
Dhankani Varsha V Department of Applied Mathematics, University of Washington, Seattle, Washington, United States of - - 2014
Herpes simplex virus-2 (HSV-2) is a chronic reactivating infection that leads to recurrent shedding episodes in the genital tract. A minority of episodes are prolonged, and associated with development of painful ulcers. However, currently, available tools poorly predict viral trajectories and timing of reactivations in infected individuals. We employed principal ...
Xi Dong D IIS Statistical Methodology, Novartis Pharmaceuticals Corporation, One Health Plaza, East Hanover, NJ, 07936, - - 2014
Graphical approaches have been proposed in the literature for testing hypotheses on multiple endpoints by recycling significance levels from rejected hypotheses to unrejected ones. Recently, they have been extended to group sequential procedures (GSPs). Our focus in this paper is on the allocation of recycled significance levels from rejected hypotheses ...
Thanh Vo Hong VH The Microsoft Research - University of Trento Centre for Computational and Systems Biology, Piazza Manifattura 1, Rovereto 38068, - - 2014
We propose a new exact stochastic rejection-based simulation algorithm for biochemical reactions and extend it to systems with delays. Our algorithm accelerates the simulation by pre-computing reaction propensity bounds to select the next reaction to perform. Exploiting such bounds, we are able to avoid recomputing propensities every time a (delayed) ...
Kulkarni Devdutt D Institute for Environmental Research, Biology V, RWTH Aachen University, Worringerweg 1, 52074 Aachen, Germany. Electronic address: - - 2014
Higher tiers of ecological risk assessment (ERA) consider population and community-level endpoints. At the population level, the phenomenon of density dependence is one of the most important ecological processes that influence population dynamics. In this study, we investigated how different mechanisms of density dependence would influence population-level ERA of the ...
Kakara Makoto M Department of Clinical Pharmacokinetics, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, - - 2014
HMG-CoA reductase inhibitors are available for use in low density lipoprotein-cholesterol (LDL-C) lowering therapy. The purposes of this study were to develop a population pharmacodynamic (PPD) model to describe the time course for the LDL-C lowering effects of statins and assess the efficacy of combination therapy based on electronic medical ...
Smith Nathaniel J NJ School of Informatics, University of Edinburgh, Edinburgh, Scotland, - - 2014
A companion paper introduced the rERP framework, which recasts traditional event-related potential (ERP) averaging as a special case of a more flexible regression-based approach to estimating ERP waveforms. Here, we build on this foundation, showing how rERP analysis can also handle the estimation of nonlinear effects (a generalization of both ...
Huggett Nick N Department of Philosophy, University of Illinois at Chicago, Chicago, - - 2014
This paper investigates the mathematical representation of time in physics. In existing theories, time is represented by the real numbers, hence their formal properties represent properties of time: these are surveyed. The central question of the paper is whether the existing representation of time is adequate, or whether it can ...
Smith Nathaniel J NJ School of Informatics, University of Edinburgh, Edinburgh, Scotland, - - 2014
ERP averaging is an extraordinarily successful method, but can only be applied to a limited range of experimental designs. We introduce the regression-based rERP framework, which extends ERP averaging to handle arbitrary combinations of categorical and continuous covariates, partial confounding, nonlinear effects, and overlapping responses to distinct events, all within ...
Klingenberg Christian Peter CP Faculty of Life Sciences, University of Manchester, Michael Smith Building, Oxford Road, Manchester M13 9PT, UK - - 2014
Although most studies on integration and modularity have focused on variation among individuals within populations or species, this is not the only level of variation for which integration and modularity exist. Multiple levels of biological variation originate from distinct sources: genetic variation, phenotypic plasticity resulting from environmental heterogeneity, fluctuating asymmetry ...
Teomy Eial E School of Mechanical Engineering, Tel Aviv University, Tel Aviv 69978, - - 2014
We calculate the corrections to the thermodynamic limit of the critical density for jamming in the Kob-Andersen and Fredrickson-Andersen kinetically-constrained models, and find them to be finite-density corrections, and not finite-size corrections. We do this by introducing a new numerical algorithm, which requires negligible computer memory since contrary to alternative ...
Cunniffe Nik J NJ Department of Plant Sciences, University of Cambridge, Cambridge, United - - 2014
A spatially-explicit, stochastic model is developed for Bahia bark scaling, a threat to citrus production in north-eastern Brazil, and is used to assess epidemiological principles underlying the cost-effectiveness of disease control strategies. The model is fitted via Markov chain Monte Carlo with data augmentation to snapshots of disease spread derived ...
Tevatia Rahul R Department of Chemical and Biomolecular Engineering, University of Nebraska-Lincoln, Lincoln, NE 68588, USA; School of Biological Sciences, University of Nebraska-Lincoln, Lincoln, NE 68588, USA. Electronic address: - - 2014
The relative effects of three precise nitrogen limitation regimes on green micro-algae were assessed using the Trebouxiophycean alga Coccomyxa subellipsoidea grown in a chemostatic bioreactor system. The data provides further evidence that growth and triglyceride (TAG) accumulation are concurrent and independently proportional to the degree of nitrogen limitation in algae. ...
Drewnowski Adam A Center for Public Health Nutrition, University of Washington, Seattle, Washington. Electronic address: - - 2014
Studies have tried to link obesity rates and physical activity with multiple aspects of the built environment. To determine the relation between residential property values and multiple perceived (self-reported) measures of the obesogenic environment. The Seattle Obesity Study (SOS) used a telephone survey of a representative, geographically distributed sample of ...
Hatakeyama Y Y Yutaka Hatakeyama, Center of Medical Information Science, Kochi University Medical School, Oko-cho Kohasu, Nankoku, Kochi, Kochi 783-8505, Japan, E-mail: - - 2014
Objectives: We developed a robust, long-term clinical prediction model to predict conditions leading to early diabetes using laboratory values other than blood glucose and insulin levels. Our model protects against missing data and noise that occur during long-term analysis. Methods: Results of a 75-g oral glucose tolerance test (OGTT) were ...
Naeem Awan Muhammad M WWF Pakistan, Regional Office, Azad Kashmir, Muzaffarabad, Pakistan. - - 2014
The cheer pheasant Catreus wallichi is a globally threatened species that inhabits the western Himalayas. Though it is well established that the species is threatened and its numbers declining, updated definitive estimates are lacking, so in 2011, we conducted a survey to assess the density, population size, and threats to ...
Kinney Justin B JB Simons Center for Quantitative Biology, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, - - 2014
The question of how best to estimate a continuous probability density from finite data is an intriguing open problem at the interface of statistics and physics. Previous work has argued that this problem can be addressed in a natural way using methods from statistical field theory. Here I describe results ...
Rodriguez Alex A SISSA (Scuola Internazionale Superiore di Studi Avanzati), via Bonomea 265, I-34136 Trieste, - - 2014
Cluster analysis is aimed at classifying elements into categories on the basis of their similarity. Its applications range from astronomy to bioinformatics, bibliometrics, and pattern recognition. We propose an approach based on the idea that cluster centers are characterized by a higher density than their neighbors and by a relatively ...
Sarkar Abhra A Department of Statistics, Texas A&M University, College Station, Texas 77843-3143, - - 2014
We consider the problem of robust estimation of the regression relationship between a response and a covariate based on sample in which precise measurements on the covariate are not available but error-prone surrogates for the unobserved covariate are available for each sampled unit. Existing methods often make restrictive and unrealistic ...
Chiu Chun-Huo CH Institute of Statistics, National Tsing Hua University, Hsin-Chu 30043, - - 2014
It is difficult to accurately estimate species richness if there are many almost undetectable species in a hyper-diverse community. Practically, an accurate lower bound for species richness is preferable to an inaccurate point estimator. The traditional nonparametric lower bound developed by Chao (1984, Scandinavian Journal of Statistics 11, 265-270) for ...
Li Mei M Centre for Protolife Research, Centre for Organized Matter Chemistry, School of Chemistry, University of Bristol, Bristol BS8 1TS, - - 2014
This review discusses recent advances in the design and construction of protocell models based on the self-assembly or microphase separation of non-lipid building blocks. We focus on strategies involving partially hydrophobic inorganic nanoparticles (colloidosomes), protein-polymer globular nano-conjugates (proteinosomes), amphiphilic block copolymers (polymersomes), and stoichiometric mixtures of oppositely charged biomolecules and ...
Wong Gerard G Baker IDI Heart and Diabetes Institute, Victoria, Australia. Department of Computing and Information Systems, The University of Melbourne, Victoria, Australia. - - 2014
Recent advances in high-throughput lipid profiling by liquid chromatography electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS) have made it possible to quantify hundreds of individual molecular lipid species (e.g. fatty acyls, glycerolipids, glycerophospholipids, sphingolipids) in a single experimental run for hundreds of samples. This enables the lipidome of large cohorts of ...
Ademi Zanfina Z Department of Medicine (RMH), Melbourne EpiCentre, The University of Melbourne and Melbourne Health, Australia; Department of Epidemiology & Preventive Medicine, Monash University, Australia. Electronic address: - - 2014
Familial hypercholesterolemia (FH) imposes significant burden of premature coronary heart disease (CHD). This study aimed to determine the cost-effectiveness of FH detection based on genetic testing, supplemented with the measurement of plasma low-density lipoprotein cholesterol concentration, and treatment with statins. A Markov model with a 10-year time horizon was constructed ...
Shakouri Mahmoud M Department of Mechanical & Industrial Engineering, Louisiana State University, Baton Rouge, LA 70803, - - 2014
This paper investigates the effect of changing work zone configurations and traffic density on performance variables and subjective workload. Data regarding travel time, average speed, maximum percent braking force and location of lane changes were collected by using a full size driving simulator. The NASA-TLX was used to measure self-reported ...
Hoppel Magdalena M University of Vienna, Research Platform, Characterisation of Drug Delivery Systems on Skin and Investigations of Involved Mechanisms, Althanstraße 14, Vienna 1090, - - 2014
The physical presence of surfactants in the skin is linked to their skin irritation potential. Combined ATR-FTIR spectroscopy and tape stripping experiments in vitro on porcine ear skin were used to investigate the spatial distribution of sodium lauryl ether sulfate (SLES) in the stratum corneum and to assess its effects ...
Gutierrez María Florencia MF Instituto Nacional de Limnología (CONICET-UNL), Ciudad Universitaria, 3000, Santa Fe, Argentina, - - 2014
Predator-prey relationships are determining factors in sustaining community structure but xenobiotics, including pesticides, have the potential to alter them, causing imbalances at the ecosystem level. Although invertebrate predation on zooplankton is of high importance in shallow lakes, there is still little information regarding disturbances on this trophic interaction. This work ...
Barraquand Frédéric F Centre d'Etudes Biologiques de Chizé, CNRS, Beauvoir-sur-Niort, France; Department of Arctic and Marine Biology, University of Tromsø, - - 2014
Population cycles in voles are often thought to be generated by one-year delayed density-dependence on the annual population growth rate. In common voles, however, it has been suggested by Turchin (2003) that some populations exhibit first-order cycles, resulting from strong overcompensation (i.e. carrying capacity overshoots in peak years, with only ...
Sofaer Helen R HR Graduate Degree Program in Ecology and Biology Department, Colorado State University 1878 Campus Delivery, Fort Collins, Colorado, - - 2014
Ecological factors often shape demography through multiple mechanisms, making it difficult to identify the sources of demographic variation. In particular, conspecific density can influence both the strength of competition and the predation rate, but density-dependent competition has received more attention, particularly among terrestrial vertebrates and in island populations. A better ...
Miguel Eve E Cirad-ES,AGIRs, (Animal et Gestion Intégrée des Risques/Animal and Integrated Risk Management), Montpellier, France; CNRS-Centre d'Ecologie Fonctionnelle et Evolutive - UMR 5175, Montpellier, France; Cirad-ES, AGIRs-RP-PCP, Harare P.O. Box 1378, Zimbabwe. Electronic address: - - 2014
The sharing of habitat by wild and domestic animals may result in pathogen transmission, notably via ectoparasite vectors such as ticks. Interfaces between protected and communal lands constitute sharp transitions between areas occupied by host communities that are extremely contrasted in terms of composition, diversity and density. Empirical characterizations of ...
Harpole Jared K - - 2014
Exploratory data analysis (EDA) can reveal important features of underlying distributions, and these features often have an impact on inferences and conclusions drawn from data. Graphical analysis is central to EDA, and graphical representations of distributions often benefit from smoothing. A viable method of estimating and graphing the underlying density ...
Bossard Robert L RL Westminster College, Salt Lake City, UT 84105, U.S.A.. - - 2014
Numbers of flea (Siphonaptera) species (flea species richness) on individual mammals should be higher on large mammals, mammals with dense populations, and mammals with large geographic ranges, if mammals are islands for fleas. I tested the first two predictions with regressions of H. J. Egoscue's trapping data on flea species ...
Moody Jeffrey W JW Mechanical and Aerospace Engineering - - 2014
In the current literature, the life cycle, technoeconomic, and resource assessments of microalgae-based biofuel production systems have relied on growth models extrapolated from laboratory-scale data, leading to a large uncertainty in results. This type of simplistic growth modeling overestimates productivity potential and fails to incorporate biological effects, geographical location, or ...
Gottscho Andrew D AD Department of Biological Sciences, Humboldt State University 1 Harpst Street, Arcata, California, 95521 ; Department of Biology, University of California Riverside, California, - - 2014
The North American deserts were impacted by both Neogene plate tectonics and Quaternary climatic fluctuations, yet it remains unclear how these events influenced speciation in this region. We tested published hypotheses regarding the timing and mode of speciation, population structure, and demographic history of the Mojave Fringe-toed Lizard (Uma scoparia), ...
Kapourchali Fatemeh Ramezani FR Fatemeh Ramezani Kapourchali, Mohammed H Moghadasian, International Nutrition Research Inc., Winnipeg, MB R3T2G4, - - 2014
In this mini-review several commonly used animal models of atherosclerosis have been discussed. Among them, emphasis has been made on mice, rabbits, pigs and non-human primates. Although these animal models have played a significant role in our understanding of induction of atherosclerotic lesions, we still lack a reliable animal model ...
Yao Ling L State Key Laboratory of Resources and Environmental Information System, Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Sciences, No.11A, Datun Road, Chaoyang, Beijing, 100101, - - 2014
Air quality problems caused by atmospheric particulate have drawn broad public concern in the global scope. In the paper, the spatiotemporal distributions of fine particle (PM2.5) and inhalable particle (PM10) concentrations estimated with the artificial neural network (ANN) over China during 2006 to 2010 have been discussed. Most high PM10 ...
Kohut Sviataslau V SV Department of Chemistry, The University of Western Ontario, London, Ontario N6A 5B7, - - 2014
We describe a method for constructing a hierarchy of model potentials approximating the functional derivative of a given orbital-dependent exchange-correlation functional with respect to electron density. Each model is derived by assuming a particular relationship between the self-consistent solutions of Kohn-Sham (KS) and generalized Kohn-Sham (GKS) equations for the same ...
Exarchos Konstantinos - - 2014
Progression of atherosclerotic process constitutes a serious and quite common condition owed to accumulation of fatty materials in the arterial wall, consequently posing serious cardiovascular complications. In this work, we assemble and analyze a multitude of heterogeneous data in order to model the progression of atherosclerosis (ATS) in coronary vessels. ...
Roy Partha Pratim PP Department of Pharmacy, Guru Ghasidas Vishwavidyalaya, Bilaspur 495009, - - 2014
The objective of the present work was tantamount to explain the antiperoxidative potential and structural requirements of twenty-eight structurally diverse classes of antioxidants on docetaxel-induced lipid peroxidation. Both experimental and computational approaches were taken to the work. The experiments were performed in vitro and goat liver was used as a ...
Pidgeon Anna M AM SILVIS Lab, Department of Forest and Wildlife Ecology, University of Wisconsin-Madison, Madison, WI, 53706, U.S.A.. - - 2014
As people encroach increasingly on natural areas, one question is how this affects avian biodiversity. The answer to this is partly scale-dependent. At broad scales, human populations and biodiversity concentrate in the same areas and are positively associated, but at local scales people and biodiversity are negatively associated with biodiversity. ...
Guo Yachong Y Departament d'Enginyeria Química, Universitat Rovira i Virgili, Av. dels Paisos Catalans 26, 43007 Tarragona, - - 2014
Coarse-grained model for saturated phospholipids: 1,2-didecanoyl-sn-glycero-3-phosphocholine (DCPC), 1,2-dilauroyl-sn-glycero-3-phosphocholine (DLPC), 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC), 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC), 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC) and unsaturated phospholipids: 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC), 1,2- dioleoyl-sn-glycero-3-phosphocholine (DOPC) is introduced within the single chain mean field theory. A single set of parameters adjusted for DMPC bilayers gives an adequate description of equilibrium and mechanical properties ...
Hedges Larry V LV Institute for Policy Research at Northwestern University, Evanston, IL, - - 2014
Cluster-randomized experiments that assign intact groups such as schools or school districts to treatment conditions are increasingly common in educational research. Such experiments are inherently multilevel designs whose sensitivity (statistical power and precision of estimates) depends on the variance decomposition across levels. This variance decomposition is usually summarized by the ...
Sodt Alexander J AJ National Heart, Lung, and Blood Institute, National Institutes of Health, Rockville, Maryland. Electronic address: - - 2014
Molecular dynamics simulations of an amphipathic helix embedded in a lipid bilayer indicate that it will induce substantial positive curvature (e.g., a tube of diameter 20 nm at 16% surface coverage). The induction is twice that of a continuum model prediction that only considers the shape of the inclusion. The discrepancy ...
Erdem Seda S Economics Division, Stirling Management School, University of Stirling, Stirling, - - 2014
An extensive literature has established that it is common for respondents to ignore attributes of the alternatives within choice experiments. In most of the studies on attribute non-attendance, it is assumed that respondents consciously (or unconsciously) ignore one or more attributes of the alternatives, regardless of their levels. In this ...
Vidal Natalia P - - 2014
The lipids of 16 farmed and wild European sea bass (Dicentrarchus labrax) samples were studied by Fourier transform infrared (FTIR) spectroscopy. The spectroscopic parameters which would be useful when distinguishing between both fish origins were analysed. It was shown, for the first time, that the frequency and the ratio between ...
Charland Scott L - - 2014
To evaluate the relationship between low-density lipoprotein cholesterol (LDL-C) concentration and the annual incidence of combined coronary heart disease (CHD) events—death or nonfatal myocardial infarction (NFMI)—by using sigmoidal maximal effect (sEmax) modeling of published data in various populations at risk for CHD events, and to use the best performing sEmax ...
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