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Mehand Massinissa Si MS Department of Chemical Engineering, École Polytechnique de Montréal, PO Box 6079, Centre-ville Station, H3C 3A7, Montréal, Québec, - - 2014
In order to improve the throughput of surface plasmon resonance-based biosensors, an on-line iterative optimization algorithm has been presented aiming at reducing experimental time and material consumption without any loss of confidence on kinetic parameters [De Crescenzo (2008) J. Mol Recognit., 21, 256-66.]. This algorithm was based on a simple ...
Figuet E E UMR 5554, ISEM, CNRS, Université Montpellier 2, Montpellier, - - 2014
Reconstructing the ancestral characteristics of species is a major goal in evolutionary and comparative biology. Unfortunately, fossils are not always available and sufficiently informative, and phylogenetic methods based on models of character evolution can be unsatisfactory. Genomic data offer a new opportunity to estimate ancestral character states, through (i) the ...
Małgorzata Wzorek W Opole University of Technology, Opole, - - 2014
The objective of this article is to elaborate a method to optimize the composition of the fuels from sewage sludge (PBS fuel - fuel based on sewage sludge and coal slime, PBM fuel - fuel based on sewage sludge and meat and bone meal, PBT fuel - fuel based on ...
Zhou Yi Y Department of Biostatistics and Bioinformatics, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA, - - 2014
Quadratic inference functions (QIFs) and estimating equations using the conjugate gradient method (CGM) for fitting marginal models to longitudinal data show appealing features in improving the efficiency without making assumptions on the correlation structure. However, our simulation study shows that both methods produce biased and inefficient estimates of regression parameters ...
Kotha Sreevani S University of Helsinki, Faculty of Pharmacy, Centre for Drug Research PO Box 56, 00014 HELSINKI, - - 2014
A virtual pharmacokinetic 3D model of the human eye is built using Comsol Multiphysics® software, which is based on the Finite Element Method (FEM). The model considers drug release from a polymer patch placed on sclera. The model concentrates on the posterior part of the eye, retina being the target ...
Linares Oscar A OA *Mathematical Medicine & Biostatistics Unit, Plymouth Pharmacokinetic Modeling Study Group, 46425 Southview Lane, Plymouth, MI 48170 †Department of Chemical Engineering, Lehigh University, Bethlehem, PA 18015 USA ‡Wayne State University Law School, 471 W Palmer Ave., Detroit, MI 48202 USA §Grace Hospice of Ann Arbor, 2755 Carpenter Rd., Ann Arbor, MI, 48108, - - 2014
To begin to address the problem of heterogeneity of distribution of oxycodone (OC) in humans, we developed an organ-specific microcirculatory capillary-tissue exchange two-compartment model for studying regional OC mass transport. The model was developed in silico. It quantifies OC's organ-specific mass transport rates, clearances and recycling, and it considers the ...
Civitello David J DJ Department of Integrative Biology, University of South - - 2014
For all parasites, transmission is composed of two processes: host contact with parasites ("exposure") and risk of infection given such contact ("susceptibility"). Classic models, such as mass action (density-dependent) transmission, lump these processes together. However, separating these processes could enhance predictions for disease dynamics, especially for free-living parasites. Here we ...
Noack Stephan S Institute of Bio- and Geosciences, IBG-1: Biotechnology, Forschungszentrum Jülich, D-52425 Jülich, - - 2014
'Mass specs are precise but biology is not!' is a frequently heard argument when quantitative experimental data do not fit into the overall picture. The problem with this opinion is that the significance of measured biological data becomes a matter of gut feeling. Doubtlessly, the measurement precision of modern mass ...
Ewing Robert G RG Pacific Northwest National Laboratory, 902 Battelle Blvd., P.O. Box 999, Richland, Washington 99352, USA. - - 2014
This paper presents results of designed experiments performed to study the effect of four factors on the detection of RDX vapors from desorption into an atmospheric flow tube mass spectrometer (AFT-MS). The experiments initially included four independent factors: gas flow rate, desorption current, solvent evaporation time and RDX mass. The ...
Lin Chiuhsiang Joe CJ Department of Industrial Management, National Taiwan University of Science and Technology, Taipei, - - 2014
The current experiment aimed to investigate the effects of weight position on movement time in target acquisition tasks. Subsequently, a simple mathematical model was developed to describe the movement time with the moments of inertia. Ten right-handed participants conducted continuous Fitts pointing tasks using a laparoscopic instrument as a long ...
Hu Jianlin - - 2014
The University of California - Davis_Primary (UCD_P) chemical transport model was developed and applied to compute the primary airborne particulate matter (PM) trace chemical concentrations from ~900 sources in California through a simulation of atmospheric emissions, transport, dry deposition and wet deposition for a 7-year period (2000-2006) with results saved ...
Luo Xin X Department of Earth Sciences, The University of Hong Kong, Hong Kong, China; The University of Hong Kong, Shenzhen Research Institude, Shenzhen, - - 2014
(224)Ra and (223)Ra are adopted as tracers to qualify submarine groundwater discharge (SGD) in Tolo Harbor, a highly urbanized embayment in Hong Kong. Based on the sampling data, a two-layered radium mass balance model is used to estimate lateral SGD and bottom SGD. Total SGD is estimated to be 1.2-3.0cmd(-1), ...
Fonseca T C Ferreira TC *Belgian Nuclear Research Centre-SCK-CEN, Boeretang, 200 Mol, 2400, Belgium; †University Hospital Gasthuisberg, Department of Radiation Oncology, Herestraat 49, B-3000, Leuven, - - 2014
A realistic computational 3D human body library, called MaMP and FeMP (Male and Female Mesh Phantoms), based on polygonal mesh surface geometry, has been created to be used for numerical calibration of the whole body counter (WBC) system of the nuclear power plant (NPP) in Doel, Belgium. The main objective ...
Rivera-Gutierrez Diego D University of - - 2014
We have created “You, M.D.”, an interactive museum exhibit in which users learn about topics in public health literacy while interacting with virtual humans. You, M.D. is equipped with a weight sensor, a height sensor and a Microsoft Kinect that gather basic user information. Conceptually, You, M.D. could use this ...
Loenneke Jeremy P JP Department of Health and Exercise Science, University of Oklahoma, Norman, OK, - - 2014
The aim of this investigation was to determine the validity of a portable ultrasound instrument for estimating adipose tissue (AT%) compared to dual-energy X-ray absorptiometry (DXA) in female collegiate gymnasts. Participants had their measurements taken in the following order: urine-specific gravity, body mass, height, ultrasound determined AT% (1-site and 3-site) ...
Plumb John M JM Department of Zoology, University of Manitoba, Z320 Duff Roblin Building, Winnipeg, MB, R3T 2N2, Canada, - - 2014
We coupled dynamic optimization and bioenergetics models to assess the assumption that lake trout (Salvelinus namaycush) depth distribution is structured by temperature, food availability, and predation risk to maximize reproductive mass by autumn spawning. Because the model uses empirical daily thermal-depth profiles recorded in a small boreal shield lake (lake ...
Lindner Robert R Department of Biomolecular Mechanisms, Max Planck Institute for Medical Research, Heidelberg, - - 2014
Hydrogen-deuterium exchange (HDX) experiments analyzed by mass spectrometry (MS) provide information about the dynamics and the solvent accessibility of protein backbone amide hydrogen atoms. Continuous improvement of MS instrumentation has contributed to the increasing popularity of this method; however, comprehensive automated data analysis is only beginning to mature. We present ...
Park Sung Kyu Robin SK Department of Chemical Physiology of The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA - - 2014
We introduce Census2, an update of a mass spectrometry data analysis tool for peptide/protein quantification. New features for analysis of isobaric labeling such as Tandem Mass Tag (TMT) or Isobaric Tags for Relative and Absolute Quantification (iTRAQ) have been added in this version, including a reporter ion impurity correction, a ...
Teleman Johan J Lund University, - - 2014
The open XML format mzML, used for representation of mass spectrometry (MS) data, is pivotal for the development of platform-independent MS analysis software. Although conversion from vendor formats to mzML must take place on a platform on which the vendor libraries are available (i.e. Windows), once mzML files have been ...
Gerber Linda M LM Department of Public Health, Weill Cornell Medical College, New York, NY; Division of Nephrology and Hypertension, Department of Medicine, Weill Cornell Medical College, New York, - - 2014
The accuracy of the spot urine analyte/creatinine ratio in estimating 24-hour excretion of the analyte is compromised because it is not adjusted for 24-hour creatinine excretion. The authors developed a model for conveniently estimating 24-hour creatinine excretion. The model was derived from 24-hour urine collections using multiple linear regression, including ...
Da Silva David D INRA, UMR 1334 Plant Genetic Improvement and Adaption (AGAP), Montpellier, - - 2014
Background and AimsDeveloping a conceptual and functional framework for simulating annual long-term carbohydrate storage and mobilization in trees has been a weak point for virtually all tree models. This paper provides a novel approach for solving this problem using empirical field data and details of structural components of simulated trees ...
Jarvas Gabor G CEITEC-Central European Institute of Technology, Brno, Czech Republic; MTA-PE Translational Glycomics Research Group, MUKKI, University of Pannonia, Veszprem, - - 2014
Capillary electrophoresis hyphenated with electrospray mass spectrometry (CE-ESI-MS) has emerged in the past decade as one of the most powerful bioanalytical techniques. As the sensitivity and efficiency of new CE-ESI-MS interface designs are continuously improving, numerical modeling can play important role during their development. In this review, different aspects of ...
Tefera Dereje Tamiru - - 2014
A two-dimensional mathematical model was developed to study competitive adsorption of n-component mixtures in a fixed-bed adsorber. The model consists of an isotherm equation to predict adsorption equilibria of n-component volatile organic compounds (VOCs) mixture from single component isotherm data, and a dynamic adsorption model, the macroscopic mass, energy and ...
Shi Xiangnan X a State Key Laboratory of Advanced Design and Manufacturing for Vehicle Body, Hunan University , Changsha , Hunan , P.R. - - 2014
The objective of this study is to investigate the effects of obesity on occupant responses in frontal crashes using whole-body human finite element (FE) models representing occupants with different obesity levels. In this study, the geometry of THUMS 4 midsize male model was varied using mesh morphing techniques with target ...
Xu Qing-Wei QW European Bioinformatics Institute (EMBL-EBI), European Molecular Biology Laboratory, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SD, UK; Department of Computer Science and Technology, Hubei University of Education, Wuhan, - - 2014
mzTab is the most recent standard format developed by the Proteomics Standards Initiative (PSI). mzTab is a flexible tab-delimited file that can capture identification and quantification results coming from mass spectrometry (MS)-based proteomics and metabolomics approaches. We here present an open-source Java Application Programming Interface (API) for mzTab called jmzTab. ...
Abazov V M VM Joint Institute for Nuclear Research, Dubna, - - 2014
We present a measurement of the direct CP-violating charge asymmetry in Ds+→ϕπ± decays where the ϕ meson decays to K+K-, using the full Run II data set with an integrated luminosity of 10.4  fb-1 of proton-antiproton collisions collected using the D0 detector at the Fermilab Tevatron Collider. The normalized difference ACP ...
Dane Adrie D - - 2014
To optimize the quality of large scale mass-spectrometry based metabolomics data obtained from semi-quantitative profiling measurements, it is important to use a strategy in which dedicated measurement designs are combined with a strict statistical quality control regime. This assures consistently high quality results across measurements from individual studies, but semi-quantitative ...
Mikalsen Svein-Ole SO Department of Science and Technology, Faculty of Natural and Health Sciences, University of the Faroe Islands, Faroe, - - 2014
Mass spectrometry-based proteomics is a bioinformatic-intensive field. Additionally, the instruments and instrument-related and analytic software are expensive. Some free Internet-based proteomics tools have gained wide usage, but there have not been any single bioinformatic framework that in an easy and intuitive way guided the user through the whole process from ...
York William S WS Complex Carbohydrate Research Center, University of Georgia, 315 Riverbend Road, Athens, GA 30602, - - 2014
The MIRAGE (Minimum Information Required for A Glycomics Experiment) initiative was founded in 2011 in order to develop guidelines for reporting the qualitative and quantitative results obtained by diverse types of glycomics analyses, including the conditions and techniques that were applied to prepare the glycans for analysis and generate the ...
Marín-Franch Iván I Grupo de Investigación en Optometría, Departamento de Óptica, Facultad de Física, Universitat de València, C/Dr. Moliner 50. Burjassot, Valencia, 46100, Spain, - - 2014
More accurate estimation of the general height of the visual field may improve our ability to detect and monitor progression of diseases affecting visual function such as glaucoma. General height (GH) can be affected by factors such as cataracts, pupillary miosis, refractive error, and learning and fatigue effects. The conventional ...
Zhang Kai K Division of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, Houston, Texas, - - 2014
The long-term health effects of coarse particular matter (PM10-2.5) are challenging to assess due to a limited understanding of the spatial variation in PM10-2.5 mass and its chemical components. We conducted a spatially intensive field study and developed spatial prediction models for PM10-2.5 mass and four selected species (copper, zinc, ...
Shoham Naama N Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Tel Aviv 69978, - - 2014
Adipogenesis and increase in fat tissue mass are mechanosensitive processes and hence should be influenced by the mechanical properties of adipocytes. We evaluated subcellular effective stiffnesses of adipocytes using atomic force microscopy (AFM) and interferometric phase microscopy (IPM), and we verified the empirical results using finite element (FE) simulations. In ...
Martinson K L KL Department of Animal Science, University of Minnesota, St. Paul, - - 2014
Excessive body weight has become a major health issue in the equine (Equus caballus) industry. The objectives were to determine if the addition of neck circumference and height improved existing body weight estimation equations; develop an equation for estimation of ideal body weight; and develop a method for assessing the ...
Kaiser Christina C Evolution and Ecology Program, International Institute for Applied Systems Analysis (IIASA), Schlossplatz 1, A-2361, Laxenburg, Austria; Department of Microbiology and Ecosystem Science, University of Vienna, Althanstrasse 14 A-1090, Vienna, - - 2014
Under the current paradigm, organic matter decomposition and nutrient cycling rates are a function of the imbalance between substrate and microbial biomass stoichiometry. Challenging this view, we demonstrate that in an individual-based model, microbial community dynamics alter relative C and N limitation during litter decomposition, leading to a system behaviour ...
Yang Yang Y Centre for Process Systems Engineering, Department of Chemical Engineering, Imperial College London, South Kensington Campus, London SW7 2AZ, - - 2014
Higher titre processes can pose facility fit challenges in legacy biopharmaceutical purification suites with capacities originally matched to lower titre processes. Bottlenecks caused by mismatches in equipment sizes, combined with process fluctuations upon scale-up, can result in discarding expensive product. This paper describes a data mining decisional tool for rapid ...
Husemann M M Biology Department, Baylor University, Waco, TX, - - 2014
The cichlid fishes of Lake Malawi represent one of the most diverse adaptive radiations of vertebrates known. Among the rock-dwelling cichlids (mbuna), closely related sympatric congeners possess similar trophic morphologies (i.e. cranial and jaw structures), defend overlapping or adjacent territories, but can be easily distinguished based on male nuptial coloration. ...
Zwierzycki Maciej M Institute of Molecular Physics, Polish Academy of Sciences, Smoluchowskiego 17, 60-179 Poznań, - - 2014
The exceptionally high mobility of carriers in graphene is one of its defining characteristics, especially in view of potential applications. Therefore it is of both practical and fundamental importance to understand the mechanisms responsible for limiting the values of the mobility. The aim of the paper is to study theoretically ...
Hoang Viet-Ngu VN Queensland University of Technology, Brisbane, Australia. Electronic address: - - 2014
This article integrates the material/energy flow analysis into a production frontier framework to quantify resource efficiency (RE). The emergy content of natural resources instead of their mass content is used to construct aggregate inputs. Using the production frontier approach, aggregate inputs will be optimised relative to given output quantities to ...
Kinney M E ME Wildlife Health Center, University of California, Davis, School of Veterinary Medicine, Davis, CA, USA; Sacramento Zoo, Sacramento, CA, - - 2014
Tulathromycin, a long acting macrolide antibiotic, has demonstrated efficacy against respiratory pathogens including Mycoplasma bovis and M. hyopneumoniae. A pharmacokinetic study was performed to evaluate the clinical applicability of tulathromycin in desert tortoises following a single intramuscular dose of 5 mg/kg. A single blood sample was collected from 110 different desert tortoises ...
Amidan Brett G - - 2014
Ensuring data quality and proper instrument functionality is a prerequisite for scientific investigation. Manual quality assurance is time consuming and subjective. Metrics for describing LC-MS data have been developed; however, the wide variety of LC-MS instruments and configurations precludes applying a simple cutoff. Using 1150 manually classified quality control (QC) ...
Favata Marc M Mathematical Sciences Department, Montclair State University, 1 Normal Avenue, Montclair, New Jersey 07043, USA; Theoretical Astrophysics, 350-17, California Institute of Technology, Pasadena, California 91125, USA; and Department of Physics, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin 53201, - - 2014
The coalescence of two neutron stars is an important gravitational wave source for LIGO and other detectors. Numerous studies have considered the precision with which binary parameters (masses, spins, Love numbers) can be measured. Here I consider the accuracy with which these parameters can be determined in the presence of ...
Dolan Matthew J MJ Theory Group, SLAC National Accelerator Laboratory, Menlo Park, California 94025, - - 2014
Until now, a phenomenologically complete analysis of the hh+2j channel at the LHC has been missing. This is mostly due to the high complexity of the involved one-loop gluon fusion contribution and the fact that a reliable estimate thereof cannot be obtained through simplified calculations in the mt→∞ limit. In ...
Abraham Yann Y 1Novartis Institute for Biomedical Research, Basel, - - 2014
Advances in instrumentation now allow the development of screening assays that are capable of monitoring multiple readouts such as transcript or protein levels, or even multiple parameters derived from images. Such advances in assay technologies highlight the complex nature of biology and disease. Harnessing this complexity requires integration of all ...
Fonteyne Margot M Laboratory of Pharmaceutical Process Analytical Technology, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium, 0032 9 264 83 55. Electronic address: - - 2014
Classically, the end-point detection during fluid bed drying has been performed using indirect parameters, such as the product temperature or the humidity of the outlet drying air. This paper aims at comparing those classic methods to both in-line moisture and solid state determination by means of Process Analytical Technology (PAT) ...
Bierkens Johan J Flemish Institute for Technological Research, Unit of Environmental Risk and Health, Boeretang 200, B-2400 Mol, Belgium. Electronic address: - - 2014
Petroleum substances are used in large quantities, primarily as fuels. They are complex mixtures whose major constituents are hydrocarbons derived from crude oil by distillation and fractionation. Determining the complete molecular composition of petroleum and its refined products is not feasible with current analytical techniques because of the huge number ...
Reuman Daniel C DC Department of Life Sciences, Imperial College London, Silwood Park Campus, Ascot, SL5 7PY, UK; Laboratory of Populations, Rockefeller University, 1230 York Ave, New York, NY, 10065, - - 2014
Distributions of species body sizes within a taxonomic group, for example, mammals, are widely studied and important because they help illuminate the evolutionary processes that produced these distributions. Distributions of the sizes of species within an assemblage delineated by geography instead of taxonomy (all the species in a region regardless ...
Khoshnevisan Benyamin B Department of Agricultural Machinery Engineering, Faculty of Agricultural Engineering and Technology, University of Tehran, Karaj, Iran. Electronic address: - - 2014
In this study the environmental impact of consolidated rice farms (CF) - farms which have been integrated to increase the mechanization index - and traditional farms (TF) - small farms with lower mechanization index - in Guilan Province, Iran, were evaluated and compared using Life cycle assessment (LCA) methodology and ...
Grimm Lars J LJ Department of Radiology, Duke University Medical Center, Box 3808, Durham, North Carolina - - 2014
The purpose of this study is to explore Breast Imaging-Reporting and Data System (BI-RADS) features as predictors of individual errors made by trainees when detecting masses in mammograms. Ten radiology trainees and three expert breast imagers reviewed 100 mammograms comprised of bilateral medial lateral oblique and craniocaudal views on a ...
VAN DER Geer Alexandra A E AA Naturalis Netherlands Biodiversity Center, Leiden, - - 2014
Endemic mammalian species on islands are generally known to have followed a different evolutionary pathway than their mainland relatives. General patterns, such as body size trends, have been described regularly. However, most island mammal species are unique and each of them is adapted to a specific local niche as part ...
Moncunill-Solé Blanca B Catalan Institute of Paleontology Miquel Crusafont, Autonomous University of Barcelona, Bellaterra, - - 2014
The island rule entails a modification of the body size of insular mammals, a character related with numerous biological and ecological variables. From the Miocene to human colonization (Holocene), Mediterranean and Canary Islands were unaltered natural ecosystems, with paleofaunas formed with endemic giant rodents among other mammals. Our aim is ...
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