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Tosh Jonathan J Health Economics and Decision Science, School of Health and Related Research (ScHARR), University of Sheffield, Regent Court, 30 Regent Street, Sheffield, South Yorkshire, S1 4DA, UK, - - 2014
The objective of the work reported in this paper was to critically assess how sequential disease-modifying anti-rheumatic drugs (DMARDs) have been modelled in the context of economic evaluation of the use of DMARDs for treatment of rheumatoid arthritis (RA). A secondary purpose was to identify the methodological challenges of modelling ...
Tu Yu-Kang YK Institute of Epidemiology & Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan (Y-KT) - - 2014
In the past decade, a new statistical method-network meta-analysis-has been developed to address limitations in traditional pairwise meta-analysis. Network meta-analysis incorporates all available evidence into a general statistical framework for comparisons of multiple treatments. Bayesian network meta-analysis, as proposed by Lu and Ades, also known as "mixed treatments comparisons," provides ...
Narayanan Unni U *Hospital for Sick Children, Toronto, ON †British Columbia Children's Hospital, Vancouver, BC, Canada ‡Children's Hospital of Philadelphia, Philadelphia, PA ∥Scripps Mercy Hospitals, San Diego, CA ¶Orlando Health, Orlando, FL §University of Southhampton, Southampton General Hospital, Hampshire, - - 2014
Existing radiographic classification schemes (eg, Tönnis criteria) for DDH quantify the severity of disease based on the position of the ossific nucleus relative to Hilgenreiner's and Perkin's lines. By definition, this method requires the presence of an ossification centre, which can be delayed in appearance and eccentric in location within ...
Liu Hong H Department of Cardiothoracic Surgery, First Affiliated Hospital of Nanjing Medical University, PR China Collaborative Group of Congenital Heart Disease, Department of Pediatric Cardiology, Jiangsu Women's and Children's Health of Nanjing Medical University, PR China Research Institute of Heart, Lung and Blood Vessel Diseases, Jiangsu Provincial Academy of Clinical Medicine, PR - - 2014
Prenatal ultrasonography is the most widely available diagnostic test for fetal congenital heart disease (CHD), but the factors influencing its diagnostic accuracy remain uncertain despite extensive research. The aim of the present study was to evaluate the potential role of demographic, clinical and ultrasonographic characteristics on diagnostic yields for detecting ...
van der Leeuw J J Department of Vascular Medicine, University Medical Center Utrecht, Utrecht, The - - 2014
Various cardiovascular prediction models have been developed for patients with type 2 diabetes. Their predictive performance in new patients is mostly not investigated. This study aims to quantify the predictive performance of all cardiovascular prediction models developed specifically for diabetes patients. Follow-up data of 453, 1174 and 584 type 2 ...
Cai Bing B Epidemiology, Pfizer Inc., Collegeville, PA, USA; Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Center for Pharmacoepidemiology Research and Training (CPeRT), University of Pennsylvania, Philadelphia, PA, - - 2014
Epidemiologic studies using electronic healthcare data often define the presence or absence of binary clinical outcomes by using algorithms with imperfect specificity, sensitivity, and positive predictive value. This results in misclassification and bias in study results. We describe and evaluate a new method called probabilistic outcome definition (POD) that uses ...
Faggion Clovis Mariano Jr CM Department of Periodontology, Faculty of Dentistry,, University of Münster, Münster, - - 2014
To evaluate the quality of reporting of logistic regression models used to assess risk factors for tooth loss in patients who have received periodontal treatment. The PubMed, EMBASE, BIOSIS Citation Index, CINAHL, Web of Science, and LILACS electronic databases were searched up to 01 March 2014 to identify interventional longitudinal ...
Wang Lili L School of Computing, Queen's University, 25 Union Street, Goodwin Hall, Kingston, Ontario K7L 3N6, - - 2014
Protein interaction network-based pathway analysis (PINBPA) for genome-wide association studies (GWAS) has been developed as a Cytoscape app, to enable analysis of GWAS data in a network fashion. Users can easily import GWAS summary-level data, draw Manhattan plots, define blocks, prioritize genes with random walk with restart, detect enriched sub-networks ...
Heffley J D JD European Centre for Environment and Human Health, University of Exeter Medical School, Truro, Cornwall, UK. - - 2014
Newly available prescription data has been used along with census data to develop a localised method for predicting pharmaceutical concentrations in sewage influent and effluent for England, and applied to a case study: the steroid estrogens estrone, 17β-estradiol, and 17α-ethinylestradiol in a selected catchment. The prescription data allows calculation of ...
Ahn Grace E GE Northwestern University, Chicago, - - 2014
Objective Most estimates of physical activity (PA) patterns in systemic lupus erythematosus (SLE) are based on subjective self-report measures prone to error. The aims of this study were to obtain objective measurements of PA using an accelerometer and estimates of energy expenditure based on the self-reported International Physical Activity Questionnaire ...
Vaitsiakhovich Tatsiana T Institute for Medical Biometry, Informatics and Epidemiology, University of Bonn, Sigmund-Freud-Str. 25, D-53105 Bonn, Germany German Center for Neurodegenerative Diseases (DZNE), Sigmund-Freud-Str. 25, D-53105 Bonn, Germany - - 2014
Meta-analysis of summary statistics is an essential approach to guarantee the success of Genome-wide association studies (GWAS). Application of the fixed or random effects model to SNP-by-SNP association tests is a standard practice. More complex methods of meta-analysis involving multiple parameters have not been used frequently, a gap that could ...
Dalla Lana Felipe F Universidade Federal do Rio Grande do Sul, Fitossanidade, Porto Alegre, RS, Brazil ; - - 2014
Meta-analytic models were used to summarize and assess the heterogeneity in the relationship between soybean yield (Y, kg/ha) and rust severity (S, %) data from uniform fungicide trials (study, k) conducted over nine growing seasons in Brazil. For each selected study, correlation (k = 231) and regression analysis (k = ...
Lee Hsin-I HI Academia - - 2014
The selective genotyping approach, where only individuals from the high and low extremes of the trait distribution are selected for genotyping and the remaining individuals are not genotyped, has been known as a cost-saving strategy to reduce genotyping work and can still maintain nearly equivalent efficiency to complete genotyping in ...
Malone Ian B IB Dementia Research Centre (DRC), Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK. Electronic address: - - 2014
Total intracranial volume (TIV/ICV) is an important covariate for volumetric analyses of the brain and brain regions, especially in studies of neurodegenerative diseases, where it can provide a proxy of maximum pre-morbid brain volume. The gold-standard method is manual delineation of brain scans, but this requires careful work by trained ...
Asmare Kassahun K School of Veterinary Medicine, Hawassa University, P.O. Box 05, Hawassa, Ethiopia, - - 2014
This meta-analysis estimates a single-group summary (effect size) for seroprevalence of Brucella spp. exposure in dairy cattle of Ethiopia. It also attempts to identify study-level variables that could explain the variation in apparent seroprevalence. The literature search was restricted to studies published in English language from January 2000 to December ...
Azagba Sunday S Propel Centre for Population Health Impact, Faculty of Applied Health Sciences, University of Waterloo, 200 University Avenue West, Waterloo, ON, N2L 3G1, Canada, - - 2014
School connectedness (SC) is associated with decreased student risk behavior and better health and social outcomes. While a considerable body of research has examined the factors associated with SC, there is limited evidence about the particular role of religiosity in shaping levels of SC. Employing data reported by junior and ...
Wang Hao - - 2014
Abstract In this paper we extend the bivariate hazard ratio to multivariate competing risks data and show that it is equivalent to the cause-specific cross hazard ratio. Two approaches are proposed to estimate these two equivalent association measures. One extends the plug-in estimator, and the other adapts the pseudo-likelihood estimator ...
Greene Barry R BR TRIL Centre, University College Dublin, Dublin, - - 2014
Frailty is an important geriatric syndrome strongly linked to falls risk as well as increased mortality and morbidity. Taken alone, falls are the most common cause of injury and hospitalization and one of the principal causes of death and disability in older adults worldwide. Reliable determination of older adults' frailty ...
Chan C W CW School of Nursing, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong - - 2014
Internet-based interventions can facilitate an anonymous environment for the management of eating disorders and there is a need for online assessment tools to be readily available. The present study aimed to validate an online version of the Eating Disorder Examination Questionnaire (EDE-Q) and to compare the goodness-of-fit of five models ...
Panter Jenna - - 2014
BackgroundActive commuting may make an important contribution to population health. Accurate measures of these behaviours are required, but it is unknown how self-reported estimates compare to those derived from objective measures. We sought to develop methods for objectively deriving time spent in specific travel behaviours from a combination of locational ...
Narikawa Kenji K 1Department of Sport and Medical Science Paramedic Course, Faculty of Medical Technology,Teikyo - - 2014
Introduction Shortening response time to an emergency call leads to the success of resuscitation by chest compression and defibrillation. However, response by ambulance or fire truck is not fast enough for resuscitation in Japan. In rural areas, response times can be more than 10 minutes. One possible way to shorten ...
Nikolakopoulou Adriani A Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, University Campus, Ioannina, 45110, - - 2014
Clinical trials are typically designed with an aim to reach sufficient power to test a hypothesis about relative effectiveness of two or more interventions. Their role in informing evidence-based decision-making demands, however, that they are considered in the context of the existing evidence. Consequently, their planning can be informed by ...
Taylor Jeremy M G JM Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, - - 2014
A recent article (Zhang et al., 2012, Biometrics 168, 1010-1018) compares regression based and inverse probability based methods of estimating an optimal treatment regime and shows for a small number of covariates that inverse probability weighted methods are more robust to model misspecification than regression methods. We demonstrate that using ...
Goode Adam P AP Duke Physical Therapy, Duke University School of Medicine, Durham, North Carolina, - - 2014
Hamstring injury is a prevalent muscle injury in sports. Inconclusive evidence exists for eccentric hamstring strengthening to prevent hamstring injuries. One reason for this discrepancy may be the influence intervention non-compliance has on individual study estimates, and therefore pooled estimates. This systematic review aims to determine the effect of eccentric ...
Bravini Elisabetta E School in Advanced Sciences and Technology in Rehabilitation Medicine and Sports, Tor Vergata University, Rome, - - 2014
To perform a comprehensive analysis of the psychometric properties and dimensionality of the Upper Limb Functional Index (ULFI), using both classical test theory and Rasch analysis (RA). Prospective, single-group observational design. A free-standing rehabilitation center. A convenience sample of 174 Italian-speaking subjects with upper limb musculoskeletal disorders. Not applicable. The ...
Galatzer-Levy Isaac R IR Department of Psychiatry, NYU School of Medicine, New York, NY, USA. Electronic address: - - 2014
There is broad interest in predicting the clinical course of mental disorders from early, multimodal clinical and biological information. Current computational models, however, constitute a significant barrier to realizing this goal. The early identification of trauma survivors at risk of post-traumatic stress disorder (PTSD) is plausible given the disorder's salient ...
Roberson Richard B - - 2014
Objective: Our objective was to examine the use and quality of exploratory factor analysis (EFA) in articles published in Rehabilitation Psychology. Design: Trained raters examined 66 separate exploratory factor analyses in 47 articles published between 1999 and April 2014. The raters recorded the aim of the EFAs, the distributional statistics, ...
Wang Yang Y Department of Pharmacy, Wuhan Children's Hospital, 100th-Hong Kong Road, Wuhan 430016, - - 2014
Aim:To develop a population pharmacokinetics model of oxcarbazepine in Chinese pediatric patients with epilepsy, and to study the interactions between oxcarbazepine and other antiepileptic drugs (AEDs).Methods:A total of 688 patients with epilepsy aged 2 months to 18 years were divided into model (n=573) and valid (n=115) groups. Serum concentrations of ...
Mitchell Emily M EM Department of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, Atlanta, GA 30322, - - 2014
The potential for research involving biospecimens can be hindered by the prohibitive cost of performing laboratory assays on individual samples. To mitigate this cost, strategies such as randomly selecting a portion of specimens for analysis or randomly pooling specimens prior to performing laboratory assays may be employed. These techniques, while ...
Cheng Cecilia - - 2014
Compared with the large body of literature on coping, coping flexibility has received relatively scant research attention, although more such studies have begun to emerge recently. Researchers have conceptualized coping flexibility in diverse ways: as a broad coping repertoire, a well-balanced coping profile, cross-situational variability in strategy deployment, a good ...
Martins A C M AC National Regulatory Agency for Private Health Insurance/Agência Nacional de Saúde Suplementar, Rio de Janeiro, RJ, Brasil; National School of Public Health/Escola Nacional de Saúde Pública Sérgio Arouca, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, - - 2014
Studies in a number of countries have shown that adverse drug events (ADE) occur frequently among hospital inpatients. The objective of this study was to conduct a systematic review of observational studies of the frequency of ADE in adult inpatients and to examine factors associated with observed heterogeneity in the ...
de Noordhout Charline Maertens CM Institute of Health and Society (IRSS), Université catholique de Louvain, Brussels, Belgium. Electronic address: - - 2014
Listeriosis, caused by Listeria monocytogenes, is an important foodborne disease that can be difficult to control and commonly results in severe clinical outcomes. We aimed to provide the first estimates of global numbers of illnesses, deaths, and disability-adjusted life-years (DALYs) due to listeriosis, by synthesising information and knowledge through a ...
Clavé A A Service de chirurgie orthopédique et traumatologique, faculté de médecine, université de Bretagne-Occidentale, hôpital de la Cavale-Blanche, CHRU de Brest, boulevard Tanguy-Prigent, 29200 Brest, - - 2014
Developmental dysplasia of the hip (DDH) leads to multiple treatment challenges during adulthood. Surgical treatment is mainly based on radiographic evaluation of the anatomical alterations. Several classification systems have been described in the published English scientific literature, but the French Cochin classification has not been used very much. Its primary ...
Rhemtulla Mijke M Programme Group Psychological Methods, Department of Psychology, University of Amsterdam, Weesperplein 4, Room 208, 1018XA, Amsterdam, Netherlands, - - 2014
In planned missingness (PM) designs, certain data are set a priori to be missing. PM designs can increase validity and reduce cost; however, little is known about the loss of efficiency that accompanies these designs. The present paper compares PM designs to reduced sample (RN) designs that have the same ...
Mauss Daniel D Mannheim Institute of Public Health, Social and Preventive Medicine, Medical Faculty Mannheim, Heidelberg University, - - 2014
The Allostatic Load Index (ALI) has been used to establish associations between stress and health-related outcomes. This review summarizes the measurement and methodological challenges of allostatic load in occupational settings. Databases of Medline, PubPsych, and Cochrane were searched to systematically explore studies measuring ALI in working adults following the PRISMA ...
Farah Breno Quintella BQ Associate Graduate Program in Physical Education, University of Pernambuco, Recife, PE, Brazil; Study and Research Group on Hemodynamics and Exercise Metabolism-GEPHEME, University of Pernambuco, Recife, PE, - - 2014
To examine the reliability of heart rate variability (HRV) parameters in adolescents and to analyse the inter- and intra-observer reliability of data analysis. The sample included 27 adolescents aged 14-19 years old. RR intervals were obtained for 10 min in the supine position on two different days (Day 1 and Day 8) ...
Schütz Helmut H Consultancy Services for Bioequivalence and Bioavailability Studies, Neubaugasse 36/11, 1070, Vienna, Austria, - - 2014
It is difficult to validate statistical software used to assess bioequivalence since very few datasets with known results are in the public domain, and the few that are published are of moderate size and balanced. The purpose of this paper is therefore to introduce reference datasets of varying complexity in ...
Gilbert Rebecca R School of Social and Community Medicine, University of Bristol, Bristol, UK - - 2014
Case-control studies are potentially open to misclassification of disease outcome which may be unrelated to risk factor exposure (non-differential), thus underestimating associations, or related to risk factor exposure (differential), thus causing more serious bias. We conducted a systematic literature review for methods of adjusting for outcome misclassification in case-control studies. ...
Al Jadda Khalifeh K Department of Computer Science, University of Georgia, Athens, GA, - - 2014
In the field of glycomics research several different techniques are used for structure elucidation. Although multiple techniques are often used to increase confidence in structure assignments most glycomics databases allow only storing of a single type of experimental data. In addition the methods used to prepare a sample for analysis ...
Yan Mei-Si MS Department of Pathology, Harbin Medical University, Harbin, People's Republic of - - 2014
The present meta-analysis aimed to investigate the association between insulin gene variable number of tandem repeats (INS VNTR) and polycystic ovary syndrome (PCOS). Systematic searches of electronic databases, reference lists of included articles, and the abstracts presented at related scientific societies meetings were performed. Statistical analyses were conducted using software ...
Suleiman Ahmed Abbas AA *Department of Pharmacology, Clinical Pharmacology Unit, University Hospital of Cologne, Cologne, Germany; †Lung Cancer Group Cologne, Department I of Internal Medicine, Center for Integrated Oncology Cologne Bonn, University Hospital of Cologne, Cologne, Germany; and ‡Department of Nuclear Medicine, Center for Integrated Oncology Cologne Bonn, University Hospital of Cologne, Cologne, - - 2014
Pharmacostatistical models can quantify different relationships and improve decision making in personalized medicine and drug development. Our objectives were to develop models describing non-small-cell lung cancer (NSCLC) dynamics during first-line treatment with erlotinib, and survival of the cohort. Data from patients with advanced NSCLC (n = 39) treated first-line with ...
Kothe Emily J EJ School of Psychology, Deakin University, Melbourne, Victoria, - - 2014
The theory of planned behaviour (TPB) has been criticized for not including interactions between major constructs thought to underlie behaviour. This study investigated the application of the TPB to the prediction of fruit and vegetable consumption across three prospective cohorts. The primary aim of the study was to investigate whether ...
Kierkels Roel G J RG University of Groningen, University Medical Center Groningen, Department of Radiation Oncology, The Netherlands. Electronic address: - - 2014
Recently, clinically validated multivariable normal tissue complication probability models (NTCP) for head and neck cancer (HNC) patients have become available. We test the feasibility of using multivariable NTCP-models directly in the optimiser for inverse treatment planning of radiotherapy to improve the dose distributions and corresponding NTCP-estimates in HNC patients. For ...
Jylhävä Juulia - - 2014
Prediction models for old-age mortality have generally relied upon conventional markers such as plasma-based factors and biophysiological characteristics. However, it is unknown whether the existing markers are able to provide the most relevant information in terms of old-age survival or whether predictions could be improved through the integration of whole-genome ...
Collyer M L ML Department of Biology, Western Kentucky University, Bowling Green, KY, - - 2014
The analysis of phenotypic change is important for several evolutionary biology disciplines, including phenotypic plasticity, evolutionary developmental biology, morphological evolution, physiological evolution, evolutionary ecology and behavioral evolution. It is common for researchers in these disciplines to work with multivariate phenotypic data. When phenotypic variables exceed the number of research subjects-data ...
Huffman Kristopher M KM *Division of Research and Optimal Patient Care, American College of Surgeons, Chicago, IL †Department of Surgery, University of California Los Angeles David Geffen School of Medicine, and VA Greater Los Angeles Healthcare System, Los Angeles, CA ‡Department of Surgery, Washington University in St. Louis; Center for Health Policy and the Olin Business School at Washington University in St Louis; John Cochran Veterans Affairs Medical Center; and BJC Healthcare, St. Louis, - - 2014
To assess statistical reliability of hospital profiling models in ACS NSQIP (American College of Surgeons' National Surgical Quality Improvement Program). The ACS NSQIP January 2013 Semiannual Report provided risk-adjusted hospital quality assessments for 137 models. Median reliability and percentage of hospitals achieving acceptable reliability were computed for each model. Average ...
Brandstätter Christian C Institute for Water Quality, Resource and Waste Management, Vienna University of Technology, Karlsplatz 13/226-2, 1040 Vienna, Austria. Electronic address: - - 2014
Municipal solid waste landfills pose a threat on environment and human health, especially old landfills which lack facilities for collection and treatment of landfill gas and leachate. Consequently, missing information about emission flows prevent site-specific environmental risk assessments. To overcome this gap, the combination of waste sampling and analysis with ...
Floros Georgios D GD 1 2nd Department of - - 2014
Summary.-This study assessed the results from the parallel application of two alternate personality models, the Zuckerman-Kuhlman trait model and Bond's Defense Styles, in a sample of 268 Greek medical students (172 women, M age = 22.0 yr., SD = 1.1; 95 men, M age = 22.3 yr., SD = 1.2) ...
Wei Wen-Hua WH 1] Arthritis Research UK Centre for Genetics and Genomics, Institute of Inflammation and Repair, University of Manchester, Manchester M13 9PT, UK. [2] Medical Research Council (MRC) Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK. - - 2014
Genome-wide association studies (GWASs) have become the focus of the statistical analysis of complex traits in humans, successfully shedding light on several aspects of genetic architecture and biological aetiology. Single-nucleotide polymorphisms (SNPs) are usually modelled as having additive, cumulative and independent effects on the phenotype. Although evidently a useful approach, ...
Jones-Jordan Lisa A LA College of Optometry, The Ohio State University, 649 Fry Hall, 338 West 10th Avenue, Columbus, OH, 43210, United States - - 2014
Purpose: To determine the correlation between sibling refractive errors adjusted for shared and unique environmental factors using data from the Collaborative Longitudinal Evaluation of Ethnicity and Refractive Error (CLEERE) Study. Methods: Refractive error from subjects' last study visits was used to estimate the intraclass correlation coefficient (ICC) between siblings. The ...
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