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Vicente Javier J Ibime Group, Universitat Politècnica de València, C/ Camino de Vera s/n, Builidng 8G, 1st floor, access B, 46022, València, Spain, - - 2015
This chapter presents a novel online method to audit predictive models using a Bayesian perspective. The auditing model has been specifically designed for Decision Support Systems (DSSs) suited for clinical or research environments. Taking as starting point the working diagnosis supplied by the clinician, this method compares and evaluates the ...
Turk Alice A Linguistics and English Language, University of Edinburgh, Edinburgh EH8 9AD, UK - - 2014
In the first part of the paper, we summarize the linguistic factors that shape speech timing patterns, including the prosodic structures which govern them, and suggest that speech timing patterns are used to aid utterance recognition. In the spirit of optimal control theory, we propose that recognition requirements are balanced ...
Prades Miriam M Department of Mechanical Engineering and Construction, Universitat Jaume I, Av Sos Baynat s/n, 12071, Castellón, Spain, - - 2015
This paper analyzes the generation and composition of municipal solid waste in Spanish towns and cities with more than 5000 inhabitants, which altogether account for 87 % of the Spanish population. To do so, the total composition and generation of municipal solid waste fractions were obtained from 135 towns and cities. ...
Dimitrakopoulou Vasiliki V Department of Hygiene and Epidemiology, School of Medicine, University of Ioannina, Ioannina, - - 2014
Missing outcome data are a problem commonly observed in randomized control trials that occurs as a result of participants leaving the study before its end. Missing such important information can bias the study estimates of the relative treatment effect and consequently affect the meta-analytic results. Therefore, methods on manipulating data ...
Zhang Xiaoshuai - - 2014
BackgroundGenome-wide Association Studies (GWAS) are typically designed to identify phenotype-associated single nucleotide polymorphisms (SNPs) individually using univariate analysis methods. Though providing valuable insights into genetic risks of common diseases, the genetic variants identified by GWAS generally account for only a small proportion of the total heritability for complex diseases. To ...
Visconti Giuseppe G Department of Plastic and Reconstructive Surgery, Università Cattolica del "Sacro Cuore" - University Hospital "A. Gemelli", Largo A. Gemelli 8, 00168, Rome, Italy, - - 2014
The navel contributes to abdominal surface identity and beauty. In Western societies, the display of the navel in women's fashion has grown and, nowadays, women are much more concerned about its shape and position. Despite this, few studies are available on navel surface anatomy and there is no standardization regarding ...
Pedicini P P Department of Radiation and Metabolic Therapies, I.R.C.C.S.-C.R.O.B, Rionero in Vulture, - - 2014
To estimate and reduce uncertainties of a self-consistent set of radiobiological parameters based on the outcome of head and neck cancer (HNC) patients treated with radiotherapy (RT). Published studies comparing at least two RT schedules for HNC patients were selected. The method used to estimate the radiobiological parameters consists of ...
Taylor Jeremy Mg JM Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI, USA - - 2014
The validation of intermediate markers as surrogate markers (S) for the true outcome of interest (T) in clinical trials offers the possibility for trials to be run more quickly and cheaply by using the surrogate endpoint in place of the true endpoint. Working within a principal stratification framework, we propose ...
Vila-Casademunt Alba A 1Vall d'Hebron Institute of Research (VHIR), Barcelona, Spain. 2Spine Surgery Unit, Hospital Vall d'Hebron, Barcelona, Spain. 3Spine Surgery Unit, Ankara Spine Center, Ankara, Turkey. 4Spine Surgery Unit, Hospital Universitario La Paz, Madrid, Spain. 5Spine Surgery Unit, Florence Nightingale Hastanesi, Istambul, Turkey. 6Spine Surgery Unit, Bordeaux University Hospital, Bordeaux, - - 2014
Study Design. Sagittal Pelvic Parameters (SPP) of a representative patient sample drawn from a consecutive adult spinal deformity database were measured using Surgimap Spine. Estimated coefficient of reliability ICC (95% CI), Standard Error of Measurement (SEM) and Mean Absolute Deviation (MAD) were used for the analysis.Objective. The primary objective of ...
Scharf Jeremiah M JM Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetics Research, Departments of Neurology and Psychiatry, Massachusetts General Hospital, Boston, Massachusetts, USA; Division of Cognitive and Behavioral Neurology, Department of Neurology, Brigham and Women's Hospital, Boston, Massachusetts, - - 2014
The aim of this study was to refine the population prevalence estimate of Tourette Syndrome (TS) in children and to investigate potential sources of heterogeneity in previously published studies. A systematic review was conducted and all qualifying published studies of TS prevalence were examined. Extracted data were subjected to a ...
Xiang Jianping J Toshiba Stroke and Vascular Research Center, University at Buffalo, State University of New York, Buffalo, New York, USA Department of Mechanical and Aerospace Engineering, University at Buffalo, State University of New York, Buffalo, New York, USA Department of Neurosurgery, University at Buffalo, State University of New York, Buffalo, New York, - - 2014
We previously established three logistic regression models for discriminating intracranial aneurysm rupture status based on morphological and hemodynamic analysis of 119 aneurysms. In this study, we tested if these models would remain stable with increasing sample size, and investigated sample sizes required for various confidence levels (CIs). We augmented our ...
Bandyopadhyay Dipankar D Division of Biostatistics, University of Minnesota School of Public Health, Minneapolis, USA - - 2014
Often in biomedical research, we deal with continuous (clustered) proportion responses ranging between zero and one quantifying the disease status of the cluster units. Interestingly, the study population might also consist of relatively disease-free as well as highly diseased subjects, contributing to proportion values in the interval [0, 1]. Regression ...
Maradit Kremers Hilal H Mayo Clinic, 200 First Street SW, Harwick 6-69, Rochester, MN, 55905, USA, - - 2014
There is increasing interest in using administrative claims data for surveillance of surgical site infections in THAs and TKAs, but the performance of claims-based models for case-mix adjustment has not been well studied. Performance of claims-based models can be improved with the addition of clinical risk factors for surgical site ...
Turner Rebecca M RM MRC Biostatistics Unit, Cambridge Institute of Public Health, Cambridge, - - 2014
Numerous meta-analyses in healthcare research combine results from only a small number of studies, for which the variance representing between-study heterogeneity is estimated imprecisely. A Bayesian approach to estimation allows external evidence on the expected magnitude of heterogeneity to be incorporated. The aim of this paper is to provide tools ...
Du Jerry Y JY Spine and Scoliosis Surgery, Hospital for Special Surgery, Weill Cornell Medical College, New York, New - - 2014
OBJECT The unique and complex biomechanics of the atlantoaxial junction make the treatment of C1-2 instability a challenge. Several screw-based constructs have been developed for atlantoaxial fixation. The biomechanical properties of these constructs have been assessed in numerous cadaver studies. The purpose of this study was to systematically review the ...
Diesfeldt H F A HF De Stichtse Hof, Naarderstraat 81, 1251 BG, Laren, The Netherlands, - - 2014
Responses of 1,442 consecutive participants in psychogeriatric day care (mean age 78.8; SD 6.5) to 15 items of a mood questionnaire were analyzed by Mokken scale analysis which is based on nonparametric item response theory models. As from 2002, 825 participants also answered eight self-esteem questions. For the purpose of ...
Voss Andreas A a Department of Psychology , University of Heidelberg , Heidelberg , - - 2014
Previous studies on attentional biases often show contradictory results. This suggests that important moderating variables have been neglected so far. We suggest that (1) control over potential consequences and (2) satisfaction with the current status are important factors that need to be considered. We explored the influence of these variables ...
Rigdon Joseph J Department of Biostatistics, University of North Carolina, Chapel Hill, NC, - - 2014
Two methods are developed for constructing randomization-based confidence sets for the average effect of a treatment on a binary outcome. The methods are nonparametric and require no assumptions about random sampling from a larger population. Both of the resulting 1 - α confidence sets are exact in the sense that ...
Forbes Andrew B AB School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia - - 2014
Cluster randomised crossover trials have been utilised in recent years in the health and social sciences. Methods for analysis have been proposed; however, for binary outcomes, these have received little assessment of their appropriateness. In addition, methods for determination of sample size are currently limited to balanced cluster sizes both ...
Lin Dan-Yu DY Department of Biostatistics, University of North Carolina, Chapel Hill, NC 27599-7420, USA. Electronic address: - - 2014
The cohort design allows investigators to explore the genetic basis of a variety of diseases and traits in a single study while avoiding major weaknesses of the case-control design. Most cohort studies employ multistage cluster sampling with unequal probabilities to conveniently select participants with desired characteristics, and participants from different ...
Gartlehner Gerald G Department for Clinical Epidemiology an Evidence-based Medicine, Austrian Cochrane Branch, Danube University Krems, Dr. Karl Dorrekstrasse 30, 3500 Krems, Austria; RTI-UNC Evidence-based Practice Center, Research Triangle Institute International, 3040 East Cornwallis Road, Research Triangle Park, NC 27709-2194, USA. Electronic address: - - 2014
We sought to determine whether producers or users of systematic reviews using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach or a close variation give the same meanings to terms intended to convey uncertainty about treatment effects when interpreting grades for the quality or strength of evidence. Following ...
Chiaravalloti-Neto Francisco F Departamento de Epidemiologia. Faculdade de Saúde Pública. Universidade de São Paulo. Av. Dr. Arnaldo, 715, 01246-904, São Paulo, SP, Brasil. Electronic address: - - 2014
The aims of this study were to describe the occurrence of dengue in space and time and to assess the relationships between dengue incidence and entomologic indicators. We selected the dengue autochthonous cases that occurred between September 2005 and August 2007 in São José do Rio Preto to calculate incidence ...
Carreira Rafael - - 2014
BackgroundFlux analysis methods lie at the core of Metabolic Engineering (ME), providing methods for phenotype simulation that allow the determination of flux distributions under different conditions. Although many constraint-based modeling software tools have been developed and published, none provides a free user-friendly application that makes available the full portfolio of ...
Zhang Ming-Jie MJ Department of Neurology, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Yuzhong District, Chongqing, PR - - 2014
Background: The association between methylenetetrahydrofolate reductase (MTHFR) gene A1298C polymorphism and adult stroke remains controversial. The present article was designed to clarify this relationship through pooled analysis of the numerous epidemiological studies focusing on this association. Methods: We comprehensively searched all published papers in electronic database including PubMed, Embase, Web ...
Yılmaz Zekiye Buket ZB Signal Transduction Laboratory, Max Delbrück Center for Molecular Medicine, Robert-Rössle-Strasse 10, 13125 Berlin, Germany. Electronic address: - - 2014
The mechanisms that govern proteolytic maturation or complete destruction of the precursor proteins p100 and p105 are fundamental to homeostasis and activation of NF-κB; however, they remain poorly understood. Using mass-spectrometry-based quantitative analysis of noncanonical LTβR-induced signaling, we demonstrate that stimulation induces simultaneous processing of both p100 and p105. The ...
van Rijn Peter P ETS Global, Amsterdam, The - - 2014
Many probabilistic models for psychological and educational measurements contain latent variables. Well-known examples are factor analysis, item response theory, and latent class model families. We discuss what is referred to as the 'explaining-away' phenomenon in the context of such latent variable models. This phenomenon can occur when multiple latent variables ...
Zhang Xu-Yao - - 2014
This brief presents a framework of retargeted least squares regression (ReLSR) for multicategory classification. The core idea is to directly learn the regression targets from data other than using the traditional zero--one matrix as regression targets. The learned target matrix can guarantee a large margin constraint for the requirement of ...
Willis Brian H BH School of Health and Population Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK. Electronic address: - - 2014
Diagnostic test accuracy studies and meta-analyses may, in some cases, provide estimates that are highly improbable in practice; tailored meta-analysis provides a potential solution. To investigate the utility of tailored meta-analysis in synthesizing estimates of a test's accuracy compared with conventional meta-analysis for three case examples. MEDLINE, Embase, and CINAHL ...
van Beek S C SC Department of Vascular Surgery, Academic Medical Centre, Amsterdam, The - - 2014
Prediction of survival after intervention for ruptured abdominal aortic aneurysms (RAAA) may support case mix comparison and tailor the prognosis for patients and relatives. The objective of this study was to assess the performance of four prediction models: the updated Glasgow Aneurysm Score (GAS), the Vancouver scoring system, the Edinburgh ...
Papageorgiou Spyridon N SN Department of Orthodontics Department of Oral Technology, School of Dentistry, University of Bonn, Bonn, - - 2014
Systematic reviews ideally provide a comprehensive and unbiased summary of existing evidence from clinical studies, whilst meta-analysis combines the results of these studies to produce an overall estimate. Collectively, this makes them invaluable for clinical decision-making. Although the number of published systematic reviews and meta-analyses in orthodontics has increased, questions ...
Papageorgiou Spyridon N SN Department of Orthodontics Department of Oral Technology, School of Dentistry, University of Bonn, Bonn, - - 2014
Systematic reviews with quantitative synthesis of included studies (meta-analysis) are being produced at increased rates in orthodontics. However, their reporting quality is often suboptimal, and methodological limitations can affect their conclusions. This article is designed to help orthodontists critically appraise the validity of a meta-analysis by providing 11 questions that ...
Schmidt James R JR Department of Experimental Clinical and Health Psychology, Ghent - - 2014
This article illustrates a shortcoming of using regression to control for confounds in nested designs. As an example, we consider the congruency sequence effect, which is the observation that the congruency effect in distractor interference (e.g., Stroop) tasks is smaller following incongruent as compared with congruent trials. The congruency sequence ...
Messori Andrea A HTA Unit, Area Vasta Centro Toscana, Regional Health System, Via San Salvi 12, 50100 Firenze, - - 2014
No equivalence analysis has yet been conducted on the effectiveness of biologics in rheumatoid arthritis. Equivalence testing has a specific scientific interest, but can also be useful for deciding whether acquisition tenders are feasible for the pharmacological agents being compared. Our search covered the literature up to August 2014. Our ...
Perry John L JL a Leeds Trinity - - 2014
Purpose: A new measure of sportspersonship, which differentiates between compliance and principled approaches, was developed and initially validated in 3 studies. Method: Study 1 developed items, assessed content validity, and proposed a model. Study 2 tested the factorial validity of the model on an independent sample. Study 3 further tested ...
Mowatt Graham G Health Services Research Unit, University of Aberdeen, Aberdeen, - - 2014
Age-related macular degeneration is the most common cause of sight impairment in the UK. In neovascular age-related macular degeneration (nAMD), vision worsens rapidly (over weeks) due to abnormal blood vessels developing that leak fluid and blood at the macula. To determine the optimal role of optical coherence tomography (OCT) in ...
Liu Bing - - 2014
(J. Sep. Sci. 2014, 37 (23), 3579-3586) DOI: 10.1002/jssc.201400799 Molecular modeling has been gradually used to design the synthesis of MIPs. Four semi-empirical algorithms were applied in the optimization of the ratios of template and monomers. The binding energies of template-monomer complexes were calculated and the docking configures were assessed ...
Kuss O O Institute for Biometry and Epidemiology, German Diabetes Center, Leibniz Institute for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, - - 2014
Meta-analyses with rare events, especially those that include studies with no event in one ('single-zero') or even both ('double-zero') treatment arms, are still a statistical challenge. In the case of double-zero studies, researchers in general delete these studies or use continuity corrections to avoid them. A number of arguments against ...
Buchanan Ashley L AL 1 Department of Biostatistics, University of North Carolina , Chapel Hill, North - - 2014
Abstract In an observational study with a time-to-event outcome, the standard analytical approach is the Cox proportional hazards regression model. As an alternative to the standard Cox model, in this article we present a method that uses inverse probability (IP) weights to estimate the effect of a baseline exposure on ...
Petrov Andrii Y AY Department of Mechanical Engineering, University of Canterbury, Christchurch, New Zealand. Electronic address: - - 2014
Rayleigh damping (RD) is commonly used to model energy attenuation for analyses of structures subjected to dynamic loads. In time-harmonic Magnetic Resonance Elastography (MRE), the RD model was shown to be non-identifiable at a single frequency data due to the ill-posed nature of the imaginary components describing energy dissipation arising ...
Gan Yonghong Y Key Lab of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, 1799 Jimei Road, Xiamen 361021, People's Republic of - - 2014
In this paper, the contribution of visual and acoustic preference to multi-sensory landscape evaluation was quantitatively compared. The real landscapes were treated as dual-sensory ambiance and separated into visual landscape and soundscape. Both were evaluated by 63 respondents in laboratory conditions. The analysis of the relationship between respondent's visual and ...
Ashrafi Elham E 1)Tehran University of Medical Sciences, International Campus (TUMS- IC), Tehran, Iran.2)Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. 3)Eye Research Center, Farabi Eye Hospital, Tehran, University of Medical Sciences, Tehran, - - 2014
Although Visual impairment (VI) and its prevention is a public health issue, sub-optimal information about its magnitude in national level and its distribution is one of the impediments for visual health advocacy. In this article, we are detailing the approaches which will be taken to estimate the magnitude (prevalence, incidence, ...
Jackson Dan D Medical Research Council Biostatistics Unit, Cambridge Institute of Public Health, Cambridge, - - 2014
The analysis of randomized controlled trials with incomplete binary outcome data is challenging. We develop a general method for exploring the impact of missing data in such trials, with a focus on abstinence outcomes. We propose a sensitivity analysis where standard analyses, which could include 'missing = smoking' and 'last observation carried ...
Villain Jonathan J Normandie University, Caen, - - 2014
The potential of quantile regression (QR) and quantile support vector machine regression (QSVMR) was analyzed for the definitions of quantitative structure-activity relationship (QSAR) models associated with a diverse set of chemicals toward a particular endpoint. This study focused on a specific sensitive endpoint (acute toxicity to algae) for which even ...
Hausner Elke E Information Management Unit, Institute for Quality and Efficiency in Health Care (IQWiG), Im Mediapark 8, 50670 Cologne, Germany. Electronic address: - - 2014
Different approaches can be adopted for the development of search strategies of systematic reviews. The objective approach draws on already established text analysis methods for developing search filters. Our aim was to determine whether the objective approach for the development of search strategies was noninferior to the conceptual approach commonly ...
Di Narzo Antonio - - 2014
BackgroundIncreasing number of eQTL (Expression Quantitative Trait Loci) datasets facilitate genetics and systems biology research. Meta-analysis tools are in need to jointly analyze datasets of same or similar issue types to improve statistical power especially in trans-eQTL mapping. Meta-analysis framework is also necessary for ChrX eQTL discovery.ResultsWe developed a novel ...
Chipeta Michael G - - 2014
It is common in public health and epidemiology that the outcome of interest is counts of events occurrence. Analysing these data using classical linear models is mostly inappropriate, even after transformation of outcome variables due to overdispersion. Zero-adjusted mixture count models such as zero-inflated and hurdle count models are applied ...
Akl Elie A - - 2014
There is no consensus on how authors conducting meta-analysis should deal with trial participants with missing outcome data. The objectives of this study are to assess in Cochrane and non-Cochrane systematic reviews: (1) which categories of trial participants the systematic review authors consider as having missing participant data (MPD), (2) ...
Schroeder J J Department of Sports Medicine, Faculty for Psychology and Human Movement Science, Institute for Human Movement Science, University of Hamburg, Turmweg 2, Hamburg, 20148, Germany, - - 2014
As reliability of raster stereography was proved only for sagittal plane parameters with repeated measures on the same day, the present study was aiming at investigating variability and reliability of back shape reconstruction for all dimensions (sagittal, frontal, transversal) and for different intervals. For a sample of 20 healthy volunteers, ...
Eichner Meri M Marine Biogeosciences, Alfred Wegener Institute, Helmholtz Centre for Polar and Marine Research, Am Handelshafen 12, 27570 Bremerhaven, Germany - - 2014
To predict effects of climate change on phytoplankton, it is crucial to understand how their mechanisms for carbon acquisition respond to environmental conditions. Aiming to shed light on the responses of extra- and intracellular inorganic C (Ci) fluxes, the cyanobacterium Trichodesmium erythraeum IMS101 was grown with different nitrogen sources (N2 ...
Stewart-Ibarra Anna M - - 2014
BackgroundDengue fever, a mosquito-borne viral disease, is a rapidly emerging public health problem in Ecuador and throughout the tropics. However, we have a limited understanding of the disease transmission dynamics in these regions. Previous studies in southern coastal Ecuador have demonstrated the potential to develop a dengue early warning system ...
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