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Mohamad Shwan S Department of ENT, Monklands Hospital, Airdrie, Scotland, ML6 - - 2014
Non-syndromic hypoplasia of the epiglottis presenting without symptoms at middle age is an extremely rare entity. We report a 50 years female who presented with oral ulcers and incidentally was found to have an asymptomatic rudimentary epiglottis and thickened bilateral aryepiglottic folds forming an inverted funnel shaped supraglottis protecting the ...
Simpson Amber L - - 2014
Surgical navigation relies on accurately mapping the intraoperative state of the patient to models derived from preoperative images. In image-guided neurosurgery, soft tissue deformations are common and have been shown to compromise the accuracy of guidance systems. In lieu of whole-brain intraoperative imaging, some advocate the use of intraoperatively acquired ...
Liu Yifang Y Department of Mechanical and Industrial Engineering, University of Toronto, 5 King's College Road, Toronto, Ontario M5S 3G8, - - 2014
To develop mathematical models to predict the evolution of tumor geometry in cervical cancer undergoing radiation therapy. The authors develop two mathematical models to estimate tumor geometry change: a Markov model and an isomorphic shrinkage model. The Markov model describes tumor evolution by investigating the change in state (either tumor ...
Son Seungsik S College of Information and Communication Engineering, Sungkyunkwan University, Suwon, Republic of - - 2014
In this paper, a mobility-aware Dual Pointer Forwarding scheme (mDPF) is applied in Proxy Mobile IPv6 (PMIPv6) networks. The movement of a Mobile Node (MN) is classified as intra-domain and inter-domain handoff. When the MN moves, this scheme can reduce the high signaling overhead for intra-handoff/inter-handoff, because the Local Mobility ...
Simon Scott - - 2013
Current technology for endovascular thrombectomy in ischemic stroke utilizes static loading and is successful in approximately 85% of cases. Existing technology uses either static suction (applied via a continuous pump or syringe) or flow arrest with a proximal balloon. In this paper we evaluate the potential of cyclic loading in ...
Fletcher John - - 2013
This paper is a critical reconsideration of Freud's analysis (1907) of Wilhelm Jensen's novella Gradiva: A Pompeian Fantasy (1903). Freud's interest was aroused by the parallels between Jensen's presentation of dreams and Freud's model of dream formation just published in The Interpretation of Dreams (1900). Freud also acclaims Jensen's presentation ...
Liu Hongbin - - 2013
This paper investigates the use of inverse finite-element modeling (IFEM)-based methods for tissue parameter identification using a rolling indentation probe for surgical palpation. An IFEM-based algorithm is proposed for tissue parameter identification through uniaxial indentation. IFEM-based algorithms are also created for locating and identifying the properties of an embedded tumor ...
Larson Nicholas B - - 2013
SUMMARY: We have developed a novel Bayesian method, PurBayes, to estimate tumor purity and detect intratumor heterogeneity based upon next-generation sequencing data of paired tumor-normal tissue samples, which utilizes finite mixture modeling methods. We demonstrate our approach using simulated data and discuss its performance under varying conditions. AVAILABILITY: Availability: PurBayes ...
Bonate Peter L PL Astellas, 1 Astellas Way, Northbrook, IL 60062, USA. - - 2013
Tumor growth profiles were simulated for 2 years using the Wang and Claret models under a phase 3 clinical trial design. Profiles were censored when tumor size increased >20% from nadir similar to clinical practice. The percent of patients censored varied from 0% (perfect case) to 100% (real-life case). The model ...
Oishi Makoto - - 2013
Object In this paper, the authors' goal was to report their novel presurgical simulation method applying interactive virtual simulation (IVS) using 3D computer graphics (CG) data and microscopic observation of color-printed plaster models based on these CG data in surgery for skull base and deep tumors. Methods For 25 operations ...
Esmaili Torshabi Ahmad - - 2013
In the radiation treatment of moving targets with external surrogates, information on tumor position in real time can be extracted by using accurate correlation models. A fuzzy environment is proposed here to correlate input surrogate data with tumor motion estimates in real time. In this study, two different data clustering ...
Chang Hang H Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA. - - 2013
Image-based classification of tissue histology, in terms of different components (e.g., subtypes of aberrant phenotypic signatures), provides a set of indices for tumor composition. Subsequently, integration of these indices in whole slide images (WSI), from a large cohort, can provide predictive models of the clinical outcome. However, the performance of ...
Cito Salvatore - - 2012
Hemodynamics applied to mechanobiology offers powerful means to predict thrombosis, and to understand the kinetics of thrombus formation on areas of vascular damage in blood flowing through the human circulatory system. Specifically, the advances in computational processing and the progress in modeling complex biological processes with spatio-temporal multi-scale methods have ...
Cui Yan - - 2012
A new method is proposed for finding a low dimensional subspace of high dimensional microarray data. We developed a new criterion for constructing the weight matrix by using local neighborhood information to discover the intrinsic discriminant structure in the data. Also this approach applies regularized least square technique to extract ...
Seitz Guido - - 2012
Animal models, including xenografts, models of metastatic invasion, syngeneic models and transgenic models, are important tools for basic research in solid pediatric tumors, while humanized animal models are useful for novel immunotherapeutical approaches. Optical and molecular imaging techniques are used for in vivo imaging and may be used in conjunction ...
Zhang Shaoyan S Unilever Discover, Colworth, England, United - - 2012
The GENEA shows high accuracy for classification of sedentary, household, walking, and running activities when sampling at 80 Hz on three axes. It is not known whether it is possible to decrease this sampling frequency and/or the number of axes without detriment to classification accuracy. The purpose of this study ...
Liu Yang - - 2012
This paper proposes an algorithm to build a set of orthogonal Point-Based Manifold Harmonic Bases (PB-MHB) for spectral analysis over point-sampled manifold surfaces. To ensure that PB-MHB are orthogonal to each other, it is necessary to have symmetrizable discrete Laplace-Beltrami Operator (LBO) over the surfaces. Existing converging discrete LBO for ...
Miyares Marta A - - 2012
Available evidence on laboratory monitoring of coagulation assays and reversal strategies for the management of hemorrhagic events associated with the newer anticoagulants is reviewed. While there are no published studies with dabigatran and prothrombinase-induced clotting time (PiCT) and no chromogenic assays available to measure the anticoagulant effects, thrombin time and ...
Vasseur E - - 2012
The time that dairy cows spend lying down is an important measure of their welfare, and data loggers can be used to automatically monitor lying time on commercial farms. To determine how the number of days of sampling, parity, stage of lactation, and production level affect lying time, electronic data ...
Stefanelli Patrizia - - 2012
In the analytical analysis the measurement uncertainty is a quantitative indicator of the confidence describing the range around a reported or experimental result within which the true value can be expected. Several approaches can be used to estimate the measurement uncertainty associated to the analysis of pesticide residues: a) the ...
Ning Zong - - 2012
BACKGROUND AND OBJECTIVE: : The current results on the diagnostic accuracy of multidetector computed tomography (MDCT) in the detection of left atrial/left atrial appendage (LA/LAA) thrombus are conflicting. The aim of the present study was to determine the diagnostic accuracy of MDCT in LA/LAA thrombus with meta-analysis. METHODS: : We ...
Zhou Baiyu - - 2012
MOTIVATION: Detecting single nucleotide polymorphism (SNP) in pooled sequencing data is more challenging than in individual sequencing because of sampling variations across pools. To effectively differentiate SNP signal from sequencing error, appropriate estimation of the sequencing error is necessary. In this paper, we propose an empirical Bayes mixture model for ...
Wills M A - - 2012
Priapulids and their extinct relatives, the archaeopriapulids and palaeoscolecids, are vermiform, carnivorous ecdysozoans with an armoured, extensible proboscis. These worms were an important component of marine communities during the Palaeozoic, but were especially abundant and diverse in the Cambrian. Today, they comprise just seven genera in four families. Priapulids were ...
Grine Frederick E - - 2012
The specific attribution of the large hominin M(2) (GDA-2) from Gondolin has significant implications for the paleobiology of Paranthropus. If it is a specimen of Paranthropus robustus it impacts that species' size range, and if it belongs to Paranthropus boisei it has important biogeographic implications. We evaluate crown size, cusp ...
Soyiri Ireneous N - - 2012
Asthma is a chronic condition of great public health concern globally. The associated morbidity, mortality and healthcare utilisation place an enormous burden on healthcare infrastructure and services. This study demonstrates a multistage quantile regression approach to predicting excess demand for health care services in the form of asthma daily admissions ...
Biro Peter A - - 2012
Sampling animals from the wild for study is something nearly every biologist has done, but despite our best efforts to obtain random samples of animals, 'hidden' trait biases may still exist. For example, consistent behavioral traits can affect trappability/catchability, independent of obvious factors such as size and gender, and these ...
Williams Amy L - - 2012
Haplotypes are an important resource for a large number of applications in human genetics, but computationally inferred haplotypes are subject to switch errors that decrease their utility. The accuracy of computationally inferred haplotypes increases with sample size, and although ever larger genotypic data sets are being generated, the fact that ...
Dwight Zachary L - - 2012
uAnalyze ^{SM} is a web-based tool for analyzing high-resolution melting data of PCR products. PCR product sequence is input by the user and recursive nearest neighbor thermodynamic calculations used to predict a melting curve similar to uMELT (http://www.dna.utah.edu/umelt/umelt.html). Unprocessed melting data is input directly from LightScanner®-96, LS32®, or HR-1 data™ ...
Gonthier Jérôme F - - 2012
The screening of molecular targets benefits from design criteria, which can identify the most promising candidates. We demonstrate that π-depleted polyaromatic molecules present superior π-stacking ability. This realization is quantified using a computational criterion, LOLIPOP, that detects ideal π-conjugated frameworks. The utility of LOLIPOP is illustrated by identifying tailored chemosensors.
Santaniello Sabato - - 2012
Accurately detecting hidden clinical or behavioral states from sequential measurements is an emerging topic in neuroscience and medicine, which may dramatically impact neural prosthetics, brain-computer interface and drug delivery. For example, early detection of an epileptic seizure from sequential electroencephalographic (EEG) measurements would allow timely administration of anticonvulsant drugs or ...
Lan Kk Gordon - - 2012
BACKGROUND: Traditional calculations of sample size do not formally incorporate uncertainty about the likely effect size. Use of a normal prior to express that uncertainty, as recently recommended, can lead to power that does not approach 1 as the sample size approaches infinity. PURPOSE: To provide approaches for calculating sample ...
Rincent R - - 2012
Genomic selection refers to the use of genotypic information for predicting breeding values of selection candidates. A prediction formula is calibrated with the genotypes and phenotypes of reference individuals constituting the calibration set. The size and the composition of this set are essential parameters affecting the prediction reliabilities. The objective ...
Malekesmaeili Mani - - 2012
A fast approximate nearest neighbor search algorithm for the (binary) Hamming space is proposed. The proposed Error Weighted Hashing (EWH) algorithm is up to 20 times faster than the popular locality sensitive hashing (LSH) algorithm and works well even for large nearest neighbor distances where LSH fails. EWH significantly reduces ...
Jahn-Eimermacher Antje - - 2012
In cluster-randomized trials, groups of individuals (clusters) are randomized to the treatments or interventions to be compared. In many of those trials, the primary objective is to compare the time for an event to occur between randomized groups, and the shared frailty model well fits clustered time-to-event data. Members of ...
Citi Luca - - 2012
The presence of recurring arrhythmic events (also known as cardiac dysrhythmia or irregular heartbeats), as well as erroneous beat detection due to low signal quality, significantly affects estimation of both time and frequency domain indices of heart rate variability (HRV). A reliable, real-time classification and correction of ECG-derived heartbeats is ...
Soleimani Roudi P - - 2012
Wheat is a common raw material used to provide most of the energy and a great portion of amino acids in poultry diets. The routine investigation of metabolizable energy (ME) and digestible amino acid content determination are costly and time consuming for wheat grains. Therefore, it would be helpful if ...
Götte Heiko - - 2012
Sample size planning should reflect the primary objective of a trial. If the primary objective is prediction, the sample size determination should focus on prediction accuracy instead of power. We present formulas for the determination of training set sample size for survival prediction. Sample size is chosen to control the ...
Alvåsen K - - 2012
An increase in on-farm mortality (euthanasia and death) in dairy herds has been reported in several countries in the last decade. This does not only imply possible problems with animal welfare, but it also causes economic losses to the farmer. The objective of this study was to evaluate time trends ...
McGree J M - - 2012
Here we present a sequential Monte Carlo approach that can be used to find optimal designs. Our focus is on the design of population pharmacokinetic studies where the derivation of sampling windows is required, along with the optimal sampling schedule. The search is conducted via a particle filter which traverses ...
Shamir Reuben R - - 2012
Background: Accurate detection of the boundaries of the subthalamic nucleus (STN) in deep brain stimulation (DBS) surgery using microelectrode recording (MER) is considered to refine localization and may therefore improve clinical outcome. However, MER tends to extend operation time and its cost-utility balance has been debated. Objectives: To quantify the ...
Tomasulo Peter A - - 2012
BACKGROUND: In spite of interventions, approximately 1000 per 1,000,000 platelet (PLT) collections are contaminated with bacteria at collection. The current prestorage culture procedure at some blood centers is to inoculate a fixed volume from the collection bag (4-8 mL) regardless of collection volume. The sensitivity of early testing varies with the ...
Lee Jinseok J Department of Biomedical Engineering, Worcester Polytechnic Institute, MA 01609, USA. - - 2013
Atrial fibrillation (AF) affects three to five million Americans and is associated with significant morbidity and mortality. Existing methods to diagnose this paroxysmal arrhythmia are cumbersome and/or expensive. We hypothesized that an iPhone 4S can be used to detect AF based on its ability to record a pulsatile photoplethysmogram signal ...
Nonclercq Antoine - - 2012
Visual quantification of interictal epileptiform activity is time consuming and requires a high level of expert's vigilance. This is especially true for overnight recordings of patient suffering from epileptic encephalopathy with continuous spike and waves during slow-wave sleep (CSWS) as they can show tens of thousands of spikes. Automatic spike ...
Su Xiaoquan - - 2012
BACKGROUND: It has long been intriguing scientists to effectively compare different microbial communities (also referred as "metagenomic samples" here) in a large scale: given a set of unknown samples, find similar metagenomic samples from a large repository, and examine how similar these samples are. With the current metagenomic samples accumulated, ...
Tang Liansheng - - 2012
This paper proposes a general framework of marker validation designs, which includes most of existing validation designs. The sample size calculation formulas for the proposed general design are derived on the basis of the optimal allocation that minimizes the expected number of treatment failures. The optimal allocation is especially important ...
Landsman V - - 2012
Analysis of population-based case-control studies with complex sampling designs is challenging because the sample selection probabilities (and, therefore, the sample weights) depend on the response variable and covariates. Commonly, the design-consistent (weighted) estimators of the parameters of the population regression model are obtained by solving (sample) weighted estimating equations. Weighted ...
Tsaliki Evdokia - - 2012
To reevaluate the efficiency of the 12 differentially methylated regions (DMRs) used in the methylated DNA immunoprecipitation (MeDIP) real-time quantitative polymerase chain reaction (real-time qPCR) based approach, develop an improved version of the diagnostic formula and perform a larger validation study. Twelve selected DMRs were checked for copy number variants ...
Gutiérrez-Redomero Esperanza - - 2012
In recent years, both scientific and judicial sources have highlighted the need for more knowledge about minutiae variability, in order to improve their statistical application to fingerprint identification. In line with this trend toward improving our knowledge of this subject, the aim of the present study was to calculate the ...
Sozu Takashi - - 2012
In the field of pharmaceutical drug development, there have been extensive discussions on the establishment of statistically significant results that demonstrate the efficacy of a new treatment with multiple co-primary endpoints. When designing a clinical trial with such multiple co-primary endpoints, it is critical to determine the appropriate sample size ...
Yuan Yuan - - 2012
Neural spike detection and classification, or spike sorting, is the first and a critical step prior to any single unit based neuroscientific studies and applications. A good spike sorter is usually characterized by high detection and classification accuracy, robust to changes in signal-to-noise ratio, objectivity in detection results or less ...
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