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Lévy-Leduc Celine C AgroParisTech/INRA MIA 518, 75005 Paris and UMR de Génétique Végétale, INRA/Univ. Paris-Sud/CNRS, 91190 Gif-sur-Yvette, - - 2014
The spatial conformation of the chromosome has a deep influence on gene regulation and expression. Hi-C technology allows the evaluation of the spatial proximity between any pair of loci along the genome. It results in a data matrix where blocks corresponding to (self-)interacting regions appear. The delimitation of such blocks ...
Kuleshov Volodymyr V Department of Computer Science, Stanford University, Stanford, CA 94305, - - 2014
Accurate haplotyping-determining from which parent particular portions of the genome are inherited-is still mostly an unresolved problem in genomics. This problem has only recently started to become tractable, thanks to the development of new long read sequencing technologies. Here, we introduce ProbHap, a haplotyping algorithm targeted at such technologies. The ...
Chang Ming M Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska University Hospital, Huddinge C1:68, SE-141 86, Stockholm, Sweden, - - 2014
Citalopram and escitalopram, selective serotonin reuptake inhibitors, are primarily metabolized by cytochrome P450 (CYP) 2C19, which is a highly polymorphic enzyme known to cause inter-individual differences in pharmacokinetics. However, the impact of CYP2C19 polymorphisms on citalopram or escitalopram exposure has yet to be fully clarified, especially with regard to the ...
Mansiaux Yohann - - 2014
Big data is steadily growing in epidemiology. We explored the performances of methods dedicated to big data analysis for detecting independent associations between exposures and a health outcome. We searched for associations between 303 covariates and influenza infection in 498 subjects (14% infected) sampled from a dedicated cohort. Independent associations ...
Luo Xiaodong X Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York 10029, - - 2014
Pocock et al. (2012, European Heart Journal 33, 176-182) proposed a win ratio approach to analyzing composite endpoints comprised of outcomes with different clinical priorities. In this article, we establish a statistical framework for this approach. We derive the null hypothesis and propose a closed-form variance estimator for the win ...
Rising Kristin L KL Department of Emergency Medicine, Thomas Jefferson University, Philadelphia, - - 2014
Although 72-hour emergency department (ED) revisits are increasingly used as a hospital metric, there is no known empirical basis for this 72-hour threshold. The objective of this study was to determine the timing of ED revisits for adult patients within 30 days of ED discharge. This was a retrospective cohort study ...
Hsieh Yi-Ling YL Department of Industrial and Physical Pharmacy, Purdue University, 575 Stadium Mall Dr., 47907, West Lafayette, Indiana, - - 2014
The aim of this study was to investigate how factors such as temperature, relative humidity and particle size impact the extent of disproportionation (salt to free base conversion) in powder blends of miconazole, benzocaine or sertraline mesylate salts mixed with a basic additive. Raman spectroscopy was used to quantitate the ...
Bogard Matthieu M INRA, UMR 1095 Génétique, Diversité et Ecophysiologie des Céréales, 5 chemin de Beaulieu, F-63039 Clermont-Ferrand, France Université Blaise Pascal, UMR 1095 Génétique, Diversité et Ecophysiologie des Céréales, F-63177 Aubière Cedex, - - 2014
Prediction of wheat phenology facilitates the selection of cultivars with specific adaptations to a particular environment. However, while QTL analysis for heading date can identify major genes controlling phenology, the results are limited to the environments and genotypes tested. Moreover, while ecophysiological models allow accurate predictions in new environments, they ...
Cong Fengyu F Department of Biomedical Engineering, Faculty of Electronic Information and Electrical Engineering, Dalian University of Technology, China; Department of Mathematical Information Technology, University of Jyväskylä, Finland. Electronic address: - - 2014
It is well-known that data of event-related potentials (ERPs) conform to the linear transform model (LTM). For group-level ERP data processing using principal/independent component analysis (PCA/ICA), ERP data of different experimental conditions and different participants are often concatenated. It is theoretically assumed that different experimental conditions and different participants possess ...
Torregroza-Vargas Nathaly M NM Urban and Regional Sustainability Group, Universidad de Los Andes, Carrera 1 Este No. 19 A - 40, Edificio Mario Laserna, Bogotá, - - 2014
Truck drivers have been involved in a significant number of road fatalities in Colombia. To identify variables that could be associated with crashes in which truck drivers are involved, a logistic regression model was constructed. The model had as the response variable a dichotomous variable that included the presence or ...
Wolf R R Department of Production Animal Health, Faculty of Veterinary Medicine, University of Calgary, Calgary, Alberta, Canada T2N 4N1. Electronic address: - - 2014
Mycobacterium avium subspecies paratuberculosis (MAP) causes chronic progressive enteritis in ruminants. The pathogen is present in most countries with modern dairy production, causing substantial economic losses for the industry. The objectives of this study were to estimate dairy herd prevalence of MAP in the Western Canadian provinces of Alberta and ...
Gray Bradley E BE Department of Psychiatry, Maryland Psychiatric Research Center, University of Maryland School of Medicine, PO Box 21247, Baltimore, MD 21228, - - 2014
Clinicians often need to evaluate the treatment response of an individual person and to know that observed change is true improvement or worsening beyond usual week-to-week changes. This paper gives clinicians tools to evaluate individual changes on the MATRICS Consensus Cognitive Battery (MCCB). We compare three different approaches: a descriptive ...
Kim Na-Rae - - 2014
In this paper, we propose a symbol interval optimization algorithm in molecular communication with drift. Proper symbol intervals are important in practical communication systems since information needs to be sent as fast as possible with low error rates. There is a trade-off, however, between symbol intervals and inter-symbol interference (ISI) ...
Gabbay-Benziv Rinat - - 2014
Abstract Objective: To predict gestational diabetes mellitus (GDM) or normoglycemic status using first trimester maternal characteristics. Methods: We used data from a prospective cohort study. First trimester maternal characteristics were compared between women with and without GDM. Association of these variables with sugar values at glucose challenge test (GCT) and ...
Rosenblatt J D JD Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, Rehovot, - - 2014
The problem of "voodoo" correlations- exceptionally high observed correlations in selected regions of the brain- is well recognized in neuroimaging. It arises when quantities of interest are estimated from the same data that was used to select them as interesting. In statistical terminology, the problem of inference following selection from ...
Mohamad Shwan S Department of ENT, Monklands Hospital, Airdrie, Scotland, ML6 - - 2014
Non-syndromic hypoplasia of the epiglottis presenting without symptoms at middle age is an extremely rare entity. We report a 50 years female who presented with oral ulcers and incidentally was found to have an asymptomatic rudimentary epiglottis and thickened bilateral aryepiglottic folds forming an inverted funnel shaped supraglottis protecting the ...
Crimmins Shawn M - - 2014
Correlative species distribution models (SDMs) are widely used in studies of climate change impacts, yet are often criticized for failing to incorporate disturbance processes that can influence species distributions. Here we use two temporally independent data sets of vascular plant distributions, climate data, and fire atlas data to examine the ...
Canessa Stefano - - 2014
The amphibian chytrid fungus, Batrachochytrium dendrobatidis, is one of the main factors in global amphibian decline. Accurate knowledge of its presence and prevalence in an area is needed to trigger conservation actions. However, imperfect capture rates determine the number of individuals caught and tested during field surveys, and contribute to ...
Simpson Amber L - - 2014
Surgical navigation relies on accurately mapping the intraoperative state of the patient to models derived from preoperative images. In image-guided neurosurgery, soft tissue deformations are common and have been shown to compromise the accuracy of guidance systems. In lieu of whole-brain intraoperative imaging, some advocate the use of intraoperatively acquired ...
Liu Yifang Y Department of Mechanical and Industrial Engineering, University of Toronto, 5 King's College Road, Toronto, Ontario M5S 3G8, - - 2014
To develop mathematical models to predict the evolution of tumor geometry in cervical cancer undergoing radiation therapy. The authors develop two mathematical models to estimate tumor geometry change: a Markov model and an isomorphic shrinkage model. The Markov model describes tumor evolution by investigating the change in state (either tumor ...
Son Seungsik S College of Information and Communication Engineering, Sungkyunkwan University, Suwon, Republic of - - 2014
In this paper, a mobility-aware Dual Pointer Forwarding scheme (mDPF) is applied in Proxy Mobile IPv6 (PMIPv6) networks. The movement of a Mobile Node (MN) is classified as intra-domain and inter-domain handoff. When the MN moves, this scheme can reduce the high signaling overhead for intra-handoff/inter-handoff, because the Local Mobility ...
Xiao Li L Department of Forest Biomaterials, North Carolina State University Raleigh, NC, - - 2014
Optimizing the use of lignocellulosic biomass as the feedstock for renewable energy production is currently being developed globally. Biomass is a complex mixture of cellulose, hemicelluloses, lignins, extractives, and proteins; as well as inorganic salts. Cell wall compositional analysis for biomass characterization is laborious and time consuming. In order to ...
Belagaje S R SR Departments of Neurology and Rehabilitation Medicine, Emory University School of Medicine, 80 Jesse Hill Jr. Drive SE, Atlanta, GA 30303, - - 2014
Several devices and medications have been used to address poststroke spasticity. Yet, spasticity's impact on outcomes remains controversial. Using data from a cohort of 460 ischemic stroke patients, we previously published a validated multivariable regression model for predicting 3-month modified Rankin Score (mRS) as an indicator of functional outcome. Here, ...
Kumar Varun V Department of Community Medicine, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi 110029, - - 2014
Background. Malaria still remains a public health problem in developing countries and changing environmental and climatic factors pose the biggest challenge in fighting against the scourge of malaria. Therefore, the study was designed to forecast malaria cases using climatic factors as predictors in Delhi, India. Methods. The total number of ...
Parrish Mark M Stowers Institute for Medical Research, 1000 E 50th Street, Kansas City, MO, 64110, - - 2014
BAC transgenesis in mice has proved to be useful in exploring the regulatory mechanisms and functions of the Hox complexes. The large constructs used may include most of the relevant components of the cis-regulatory landscape. Manipulations can be accomplished without compromising the integrity of the endogenous complex which reduces the ...
Gharghan Sadik K SK Department of Electrical, Electronic and System Engineering, Faculty of Engineering and Built Environment, Universiti Kebangsaan Malaysia, UKM Bangi, 43600 Selangor, Malaysia. - - 2014
In a wireless sensor network (WSN), saving power is a vital requirement. In this paper, a simple point-to-point bike WSN was considered. The data of bike parameters, speed and cadence, were monitored and transmitted via a wireless communication based on the ZigBee protocol. Since the bike parameters are monitored and ...
Cao Hui-Hui HH The Key Laboratory of Molecular Biology for High Cancer Incidence Coastal Chaoshan Area, Shantou University Medical College, Shantou, Guangdong, China; Institute of Oncologic Pathology, Shantou University Medical College, Shantou, Guangdong, - - 2014
Esophageal squamous cell carcinoma (ESCC) has the highest mortality rates in China. The 5-year survival rate of ESCC remains dismal despite improvements in treatments such as surgical resection and adjuvant chemoradiation, and current clinical staging approaches are limited in their ability to effectively stratify patients for treatment options. The aim ...
Downey Sean S SS Department of Anthropology, University of Maryland, College Park, Maryland, United States of America; Institute of Archaeology, University College London, London, United - - 2014
Analysis of the proportion of immature skeletons recovered from European prehistoric cemeteries has shown that the transition to agriculture after 9000 BP triggered a long-term increase in human fertility. Here we compare the largest analysis of European cemeteries to date with an independent line of evidence, the summed calibrated date ...
McFarland Lynne V LV Department of Medicinal Chemistry, School of Pharmacy, University of Washington, Seattle, Washington, - - 2014
To assess the evidence for the claim probiotics can correct dysbiosis of the normal microbiota resulting from disease or disruptive events. Systematic review of published clinical trials of patients receiving a probiotic intervention for the prevention or treatment of various diseases. Sources searched (1985-2013): PubMed, EMBASE, Cochrane Database of Systematic ...
Marschollek Michael M Peter L. Reichertz Institute for Medical Informatics, University of Braunschweig - Institute of Technology and Hannover Medical School, Hannover, - - 2014
While many studies have identified associations of physical activity with both mortality and morbidity, the effects of different dose-patterns are still unclear. Employing the recently introduced ATLAS index, the aim of the research work for this paper was to investigate whether physical activity phenotypes can actually be extracted from a ...
Hund Hauke H Department of Cardiology, University Hospital Heidelberg, Heidelberg, - - 2014
In this paper we present a method for processing EHR data into a longitudinal data model and examples for using this model to identify patients cross-sectionally and longitudinally as well as testing study designs retrospectively. Our data model describes measurements on four dimensions: the associated patient, observed feature, data source ...
Xue Tianyu T College of Computer and Information Engineering, Henan Normal University, Xinxiang 453007, - - 2014
Rough set theory is a suitable tool for dealing with the imprecision, uncertainty, incompleteness, and vagueness of knowledge. In this paper, new lower and upper approximation operators for generalized fuzzy rough sets are constructed, and their definitions are expanded to the interval-valued environment. Furthermore, the properties of this type of ...
Hadji Brahim B Georges Pompidou European University Hospital (HEGP), Paris, - - 2014
: The evaluation of end-user satisfaction is an essential part of any clinical information system (CIS) project. The purpose of this study is to evaluate the determinants of CIS continuance intention in a late post-adoption phase at the Georges Pompidou University Hospital (HEGP) in Paris. We designed an electronic survey ...
Löpprich Martin M Institute of Medical Biometry and Informatics, Heidelberg University, - - 2014
Integration and analysis of clinical data collected in multiple data sources over a long period of time is a major challenge even when data warehouses and metadata registries are used. Since most metadata registries focus on describing data elements to establish domain consistent data definition and providing item libraries, hierarchical ...
Simon Scott - - 2013
Current technology for endovascular thrombectomy in ischemic stroke utilizes static loading and is successful in approximately 85% of cases. Existing technology uses either static suction (applied via a continuous pump or syringe) or flow arrest with a proximal balloon. In this paper we evaluate the potential of cyclic loading in ...
Fletcher John - - 2013
This paper is a critical reconsideration of Freud's analysis (1907) of Wilhelm Jensen's novella Gradiva: A Pompeian Fantasy (1903). Freud's interest was aroused by the parallels between Jensen's presentation of dreams and Freud's model of dream formation just published in The Interpretation of Dreams (1900). Freud also acclaims Jensen's presentation ...
Liu Hongbin - - 2013
This paper investigates the use of inverse finite-element modeling (IFEM)-based methods for tissue parameter identification using a rolling indentation probe for surgical palpation. An IFEM-based algorithm is proposed for tissue parameter identification through uniaxial indentation. IFEM-based algorithms are also created for locating and identifying the properties of an embedded tumor ...
Larson Nicholas B NB Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55901, USA. - - 2013
We have developed a novel Bayesian method, PurBayes, to estimate tumor purity and detect intratumor heterogeneity based on next-generation sequencing data of paired tumor-normal tissue samples, which uses finite mixture modeling methods. We demonstrate our approach using simulated data and discuss its performance under varying conditions. PurBayes is implemented as ...
Bonate Peter L PL Astellas, 1 Astellas Way, Northbrook, IL 60062, USA. - - 2013
Tumor growth profiles were simulated for 2 years using the Wang and Claret models under a phase 3 clinical trial design. Profiles were censored when tumor size increased >20% from nadir similar to clinical practice. The percent of patients censored varied from 0% (perfect case) to 100% (real-life case). The model ...
Oishi Makoto - - 2013
Object In this paper, the authors' goal was to report their novel presurgical simulation method applying interactive virtual simulation (IVS) using 3D computer graphics (CG) data and microscopic observation of color-printed plaster models based on these CG data in surgery for skull base and deep tumors. Methods For 25 operations ...
Esmaili Torshabi Ahmad - - 2013
In the radiation treatment of moving targets with external surrogates, information on tumor position in real time can be extracted by using accurate correlation models. A fuzzy environment is proposed here to correlate input surrogate data with tumor motion estimates in real time. In this study, two different data clustering ...
Chang Hang H Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA. - - 2013
Image-based classification of tissue histology, in terms of different components (e.g., subtypes of aberrant phenotypic signatures), provides a set of indices for tumor composition. Subsequently, integration of these indices in whole slide images (WSI), from a large cohort, can provide predictive models of the clinical outcome. However, the performance of ...
Cito Salvatore - - 2012
Hemodynamics applied to mechanobiology offers powerful means to predict thrombosis, and to understand the kinetics of thrombus formation on areas of vascular damage in blood flowing through the human circulatory system. Specifically, the advances in computational processing and the progress in modeling complex biological processes with spatio-temporal multi-scale methods have ...
Cui Yan - - 2012
A new method is proposed for finding a low dimensional subspace of high dimensional microarray data. We developed a new criterion for constructing the weight matrix by using local neighborhood information to discover the intrinsic discriminant structure in the data. Also this approach applies regularized least square technique to extract ...
Seitz Guido - - 2012
Animal models, including xenografts, models of metastatic invasion, syngeneic models and transgenic models, are important tools for basic research in solid pediatric tumors, while humanized animal models are useful for novel immunotherapeutical approaches. Optical and molecular imaging techniques are used for in vivo imaging and may be used in conjunction ...
Zhang Shaoyan S Unilever Discover, Colworth, England, United - - 2012
The GENEA shows high accuracy for classification of sedentary, household, walking, and running activities when sampling at 80 Hz on three axes. It is not known whether it is possible to decrease this sampling frequency and/or the number of axes without detriment to classification accuracy. The purpose of this study ...
Liu Yang - - 2012
This paper proposes an algorithm to build a set of orthogonal Point-Based Manifold Harmonic Bases (PB-MHB) for spectral analysis over point-sampled manifold surfaces. To ensure that PB-MHB are orthogonal to each other, it is necessary to have symmetrizable discrete Laplace-Beltrami Operator (LBO) over the surfaces. Existing converging discrete LBO for ...
Miyares Marta A - - 2012
Available evidence on laboratory monitoring of coagulation assays and reversal strategies for the management of hemorrhagic events associated with the newer anticoagulants is reviewed. While there are no published studies with dabigatran and prothrombinase-induced clotting time (PiCT) and no chromogenic assays available to measure the anticoagulant effects, thrombin time and ...
Vasseur E - - 2012
The time that dairy cows spend lying down is an important measure of their welfare, and data loggers can be used to automatically monitor lying time on commercial farms. To determine how the number of days of sampling, parity, stage of lactation, and production level affect lying time, electronic data ...
Stefanelli Patrizia - - 2012
In the analytical analysis the measurement uncertainty is a quantitative indicator of the confidence describing the range around a reported or experimental result within which the true value can be expected. Several approaches can be used to estimate the measurement uncertainty associated to the analysis of pesticide residues: a) the ...
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