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Cunha Karin - - 2014
BackgroundSkin neurofibromas represent one of the main clinical manifestations of neurofibromatosis 1, and their number varies greatly between individuals. Quantifying their number is an important step in the methodology of many clinical studies, but counting neurofibromas one by one in individuals with thousands of tumors is arduous, time-consuming, and subject ...
Chaspari Theodora - - 2014
Biometric sensors and portable devices are being increasingly embedded into our everyday life, creating the need for robust physiological models that efficiently represent, analyze, and interpret the acquired signals. We propose a knowledgedriven method to represent electrodermal activity (EDA), a psychophysiological signal linked to stress, affect, and cognitive processing. We ...
Shiihara Y Y Institute of Industrial Science, The University of Tokyo, Meguro-ku, Tokyo, - - 2014
Extensive skin wrinkling during facial expressions is one of the considerable problems in aesthetic dermatology. Although a few in silico studies have been performed with the aim of revealing the mechanism of a wrinkled appearance, there have been few studies that take into account the influence of skin roughness (i.e. ...
Groeber F F Project Group Regenerative Technologies in Oncology, Fraunhofer Institute for Interfacial Engineering and Biotechnology (IGB), Roentgenring 11, Wuerzburg, 97070, - - 2014
Reconstructed human epidermis (RHE) is standardly used for the risk assessment of chemical compounds. However, analysis is dependent on invasive methods such as histological processing or 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) staining. As an alternative, we have developed a non-destructive technology to analyze the integrity of epidermal equivalents based on impedance spectroscopy. ...
Valero C C Structural and SolidsMechanics Division, Mechanical Engineering Department, Multiscale in Mechanical and Biological Engineering (M2BE), Aragón Institute of Engineering Research (I3A), University of Zaragoza, María de Luna 3, 50018, Saragossa, Spain, - - 2014
Numerical models have become one of the most powerful tools in biomechanics and mechanobiology allowing highly detailed simulations. One of the fields in which they have broadly evolved during the last years is in soft tissue modeling. Particularly, wound healing in the skin is one of the processes that has ...
Sprigle Stephen S Stephen Sprigle, PhD, PT • Professor • Applied Physiology, Bioengineering & Industrial Design • Georgia Institute of Technology • Atlanta, - - 2014
To provide information about the impact of a proper wheelchair fit on the posture and function of wheelchair users. This continuing education activity is intended for clinicians with an interest in skin and wound care. After participating in this educational activity, the participant should be better able to:1. Recognize the ...
Pettersson E E Department of Medical and Health Sciences, Division of Community Medicine, Primary Care, Linköping University , Sweden - - 2014
Abstract Conventional skin UV-sensitivity phototesting is based on semi-quantitative assessment of minimal erythema dose (MED). This study demonstrates a method for quantitative MED determination, using a lengthwise attenuating UVB-field combined with tissue viability imaging (TiVi). The study aim was to investigate the agreement between MED acquired by traditional phototest and ...
Lee Jun Yong JY Department of Plastic and Reconstructive Surgery, Incheon St. Mary's Hospital, College of Medicine, The Catholic University, - - 2014
To date, heat conduction from heat sources to tissue has been estimated by complex mathematical modeling. In the present study, we developed an intuitive in vitro skin burn model that illustrates heat conduction patterns inside the skin. This was composed of tightly compressed thermal papers with compression frames. Heat flow ...
Larner J J Research Centre for Topical Drug Delivery and Toxicology, School of Pharmacy, University of Hertfordshire, Hatfield, Hertfordshire, UK, - - 2014
Incontinence-associated dermatitis (IAD) is a painful yet preventable form of cumulative skin irritation prevalent amongst those with limited movement. Consequently, it has a significant impact on the quality of life for those affected as well as substantial cost implications. Prevention and intervention is typically through good skin hygiene regimes and ...
Fiorelli Alfonso A Thoracic Surgery Unit, Second University of Naples, Naples, - - 2014
As airway management specialists, thoracic surgeons should be familiar with percutaneous dilatational tracheostomy. To optimize the learning curve, we propose a home-made pig model obtained from a slaughterhouse for training residents in the technical aspects of performing percutaneous dilatational tracheostomy. The satisfaction of the residents' training experience using this model ...
Cooper Racheal R Department of Mathematics and Applied Mathematics, Virginia Commonwealth University, Richmond, VA 23284-2014, USA; The VCU Johnson Center, Virginia Commonwealth University Medical Center, Richmond, VA 23298-0614, - - 2014
The normal wound healing response is characterized by a progression from clot formation, to an inflammatory phase, to a repair phase, and finally, to remodeling. In many chronic wounds there is an extended inflammatory phase that stops this progression. In order to understand the inflammatory phase in more detail, we ...
Chen Longjian L College of Engineering, China Agricultural University (East Campus), P.O. Box 191, 17 Qing-Hua-Dong-Lu, Beijing, 100083, People's Republic of - - 2014
To develop in-silico model for predicting percutaneous absorption and disposition kinetics of chemicals in skin layers so as to facilitate the design of transdermal drug delivery systems and skin care products, and risk assessment of occupational or consumer exposure. A general-purpose computer model for simulating skin permeation, absorption and disposition ...
Billings Paul C PC Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, - - 2014
Colorimetric staining techniques such as immunohistochemistry (IHC), immunofluorescence (IF) and histochemistry (HC) provide useful information regarding the localization and relative amount of a molecule/substance in skin. We have developed a novel, straightforward method to assess colorimetric staining by combining features from two open-source software programs. As a proof of principle, ...
Somer D D DD Zienkiewicz Centre for Computational Engineering, College of Engineering, Swansea University, Singleton Park, Swansea SA2 8PP, UK. Electronic address: - - 2014
From the macroscopic mechanical deformation of skin to the feeling of touch is a chain of complex events whereby information is converted from one form to another between different scales. An important link in this chain is receptor activation, which requires incorporation of microanatomical, cellular and ion channel transduction models. ...
Biswas Abhijit - - 2014
This paper describes a multiscale analytical model of lamellarstructure and biomechanical response of Pacinian Corpuscle (PC). In order to analyze the contribution of the PC lamellarstructure for detecting high frequency vibrotactile (VT) stimuli, covering few 10s of Hz to few kHz, the model response is studied against trapezoidal and sinusoidal ...
Dibai-Filho Almir Vieira AV Doctoral Student, Laboratory of Physiotherapeutic Resources, Postgraduate Program in Rehabilitation and Functional Performance, University of São Paulo, Ribeirão Preto, SP, - - 2014
The aim of this study was to review recent studies published on the use of infrared thermography for the assessment of myofascial trigger points (MTrPs). A search of the MEDLINE, CINAHL, PEDro, and SciELO databases was carried out between November 2012 and January 2013 for articles published in English, Portuguese, ...
Corazza Monica M From the *Dipartimento di Scienze Mediche, Sezione di Dermatologia e Malattie Infettive, and †Dipartimento di Scienze Chimiche e Farmaceutiche, Università degli Studi di Ferrara, - - 2014
Barrier creams (BCs) represent devices aiming to protect the skin from contact with exogenous hazardous substances, especially under working conditions. By preventing penetration and absorption of contaminants, BCs are designed to reduce the risk of developing both irritant and allergic contact dermatitis. In fact, BCs should improve stratum corneum hydration ...
Sanguigno Luca L Department of Molecular Medicine and Medical Biotechnology, School of Medicine, Federico II University of Naples, Via Pansini 5, 80131 Naples, - - 2014
Triticum vulgare has been extensively used in traditional medicine thanks to its properties of accelerating tissue repair. The aqueous extract of Triticum vulgare (TVE) is currently an active component used by Farmaceutici Damor in the manufacture of certain pharmaceutical products already marketed in Italy and abroad under the brand name ...
Gainza Garazi G NanoBioCel Group, Laboratory of Pharmaceutics, School of Pharmacy, University of the Basque Country, Vitoria, Spain; Biomedical Research Networking Centre in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Vitoria, - - 2014
The development of an effective treatment able to reduce the healing time of chronic wounds is a major health care need. In this regard, our research group has recently demonstrated the in vivo effectiveness of the topical administration of rhEGF-loaded lipid nanoparticles in healing-impaired db/db mice. Here we report the ...
Khan Sadaf S Department of Surgery, Case Western Reserve University, Cleveland, OH, USA - - 2014
We describe an economical and simple abdominal wall model that provides a realistic experience for trainees as they develop the skills of creating an abdominal incision through the midline, followed by closure of the fascia and skin.
Sahmel Jennifer J Cardno ChemRisk, 4840 Pearl East Circle, Suite 300 West, Boulder, CO 80301, USA - - 2014
There are currently no published empirical data that characterize hand-to-mouth transfer efficiencies for metallic lead. The purpose of this study was to quantify the hand-to-mouth transfer efficiency of lead in adult volunteers (n = 6) using human saliva as a surrogate for the mouth and commercially available, 100% lead fishing ...
Domergue Sophie S From the *Inserm, U844, Hôpital Saint-Eloi, Montpellier, France; †Université MONTPELLIER 1, UFR de Médecine, Montpellier, France; ‡Service de Chirurgie Maxillo-Faciale, Chirurgie Plastique Reconstructrice et Esthétique, Hôpital Gui de Chauliac, Montpellier, France; and §Service d'immuno-Rhumatologie, Hôpital Lapeyronie, Montpellier, - - 2014
Skin burn injuries affect approximately 500,000 people per year in France. After deep burns, functional sequelae associated with hypertrophic and retractile scars are an important public health problem. To understand the pathophysiology of sequelae and evaluate new therapeutic approaches, the use of animal models that should be standard tools is ...
Rubino C M CM Institute for Clinical Pharmacodynamics Inc., Latham, NY, US - - 2014
BC-3781, a pleuromutilin antimicrobial agent, is being developed for the treatment of patients with acute bacterial infections including skin and skin structure infections (ABSSSI) and community-acquired bacterial pneumonia (CABP). Data from a Phase 2 study in patients with ABSSSI were used to refine a previous population pharmacokinetic (PK) model and ...
Planz Viktoria V Department of Biopharmaceutics and Pharmaceutical Technology, Saarland University, Saarbruecken, - - 2014
Considering the increasing incidence of chronic wounds and severe wound infections, effective drug delivery to wounded skin is of high importance. The rational development of novel therapeutic systems requires appropriate in vitro testing methodologies. In this context, suitable and reliable in vitro models simulating human wounds and advanced analytical techniques ...
Davies Diane J DJ Dermal Technology Laboratory Ltd, Keele, Staffordshire, - - 2014
The conventional safety approach that includes dermal absorption of pharmaceutical or consumer products uses models that are based on intact skin. However, when products are intended for application to skin with a less effective barrier, such as in new-born infants, or in cases where the skin is mildly damaged or ...
Yoshida Kenichiro K Tokyo University of Agriculture & Technology, Graduate School of Bio-applications & Systems Engineering, 2-24-16 Naka-cho, Koganei, Tokyo 184-8588, - - 2014
To rapidly derive a result for diffuse reflectance from a multilayered model that is equivalent to that of a Monte-Carlo simulation (MCS), we propose a combination of a layered white MCS and the adding-doubling method. For slabs with various scattering coefficients assuming a certain anisotropy factor and without absorption, we ...
Shen Jie J Research Institute for Fragrance Materials, Inc., 50 Tice Blvd., Woodcliff Lake, NJ 07677, - - 2014
Fragrance materials are widely used in cosmetics and other consumer products. Research Institute for Fragrance Materials (RIFM) evaluates the safety of these ingredients and skin absorption is an important parameter in refining systemic exposure. Currently, RIFM's safety assessment process assumes 100% skin absorption when experimental data are lacking. This 100% ...
Duangjit Sureewan S - - 2014
Microemulsions (ME) have gained attention as an alternative pharmaceutical formulation for transdermal delivery systems. However, the complicated relationships between various ME compositions (causal factors) and their characteristics (response variable) have not been fully comprehended. To overcome this problem, the design and development of ME for transdermal delivery was performed in ...
Proenca Hugo - - 2014
The concept of periocular biometrics emerged to improve the robustness of iris recognition to degraded data. Being a relatively recent topic, most of the periocular recognition algorithms work in a holistic way, and apply a feature encoding / matching strategy without considering each biological component in the periocular area. This ...
Yue Xu X School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts, USA ; Now at School of Forestry and Environmental Studies, Yale University, New Haven, Connecticut, - - 2014
We estimate area burned in southern California at mid-century (2046-2065) for the Intergovernmental Panel on Climate Change (IPCC) A1B scenario. We develop both regressions and a parameterization to predict area burned in three ecoregions, and apply present-day (1981-2000) and future meteorology from the suite of general circulation models (GCMs) to ...
Battista Anna A Institute for Theoretical Physics, Heidelberg University, Heidelberg, Germany and BioQuant, Heidelberg University, Heidelberg, - - 2014
Malaria is transmitted to vertebrates via a mosquito bite, during which rodlike and crescent-shaped parasites, called sporozoites, are injected into the skin of the host. Searching for a blood capillary to penetrate, sporozoites move quickly in locally helical trajectories, that are frequently perturbed by interactions with the extracellular environment. Here ...
Li Zongxi Z Wellman Center for Photomedicine, Harvard Medical School, Massachusetts General Hospital, 149 13th Street, Charlestown, Massachusetts 02129, - - 2014
Oxygen plays an important role in wound healing, as it is essential to biological functions such as cell proliferation, immune responses and collagen synthesis. Poor oxygenation is directly associated with the development of chronic ischemic wounds, which affect more than 6 million people each year in the United States alone ...
Cabibihan John-John - - 2014
To touch and be touched are vital to human development, well-being, and relationships. However, to those who have lost their arms and hands due to accident or war, touching becomes a serious concern that often leads to psychosocial issues and social stigma. In this paper, we demonstrate that the touch ...
Monroe Benjamin P - - 2014
Tanapox virus is a zoonotic infection that causes mild febrile illness and one to several nodular skin lesions. The disease is endemic in parts of Africa. The principal reservoir for the virus that causes Tanapox is unknown, but has been hypothesized to be a non-human primate. This study employs ecological ...
Nicoletti Giovanni G 1 Plastic and Reconstructive Surgery, Department of Clinical Surgical Diagnostic and Pediatric Sciences, University of Pavia , Pavia, Italy - - 2014
Abstract Objective: An experimental study was conducted to assess the effectiveness and safety of an innovative quadripolar variable electrode configuration radiofrequency device with objective measurements in an ex vivo and in vivo human experimental model. Background data: Nonablative radiofrequency applications are well-established anti-ageing procedures for cosmetic skin tightening. Methods: The ...
Vieille-Petit Aline A Department of Dermatology, University of California San Francisco, San Francisco, Calif., - - 2014
Background: Percutaneous penetration of urea in vivo in man has been documented. If urea can penetrate the skin, it may also move laterally. Lateral spreading of topical substances leads to unpredictable penetration dynamics and increased skin surface area exposure. Methods: The ability of urea, a low molecular-weight hydrophilic model, to ...
Turner Neill J NJ University of Pittsburgh, McGowan Institute for Regenerative Medicine , 450 Technology Drive , Suite 300 , Pittsburgh, Pennsylvania, United States, 15212 , 412 624 5272 ; - - 2014
Porcine skin is commonly used as a model for human skin injury and as a source material for biologic scaffold materials. Although remarkable similarities between porcine and human skin exist, regional anatomic variations present in human skin are also present in porcine skin. The objective of the present study was ...
Geyer Stefan H SH 1MRC National Institute for Medical Research,London,NW7 - - 2014
We evaluate the usefulness of digital volume data produced with the high-resolution episcopic microscopy (HREM) method for visualizing the three-dimensional (3D) arrangement of components of human skin, and present protocols designed for processing skin biopsies for HREM data generation. A total of 328 biopsies collected from normally appearing skin and ...
Cronin Adam L AL United Graduate School of Agricultural Sciences, Iwate University, 3-18-8 Ueda, Morioka 020-8550, Japan - - 2014
Individuals derive many benefits from being social, one of which is improved accuracy of decision-making, the so-called 'wisdom of the crowds' effect. This advantage arises because larger groups can pool information from more individuals. At present, limited empirical data indicate that larger groups outperform smaller ones during consensus decision-making in ...
Kumar Amit A Pharmaceutics Division, College of Pharmacy, The University of Texas at Austin , Austin, TX , USA - - 2014
Abstract Context: Facial hirsutism is a cosmetic concern for women and can lead to significant anxiety and lack of self-esteem. Eflornithine cream is indicated for the treatment of facial hirsutism. However, limited success rate and overall patient's satisfaction, even with a long-term and high-frequency application, leave room for improvement. Objective: ...
Jackson Adam A From the Manchester Medical School (A.J.), The University of Manchester, Manchester; Lancashire Teaching Hospitals NHS Trust (S.R.), Chorley; and University of Central Lancashire (S.R.), Preston, Lancashire, United - - 2014
Sharp debridement is the criterion standard treatment for diabetic foot ulcers (DFUs) and is performed by podiatrists in the United Kingdom. This study aimed to create a DFU model that could be used as a learning tool for trainees. In a pilot study, a penny-sized circle was drawn onto an ...
Boran Fatih Emre - - 2014
Linguistic summarization has turned out to be an important knowledge discovery technique by providing the most relevant natural language-based sentences in a human consistent manner. While many studies on linguistic summarization have handled ordinary fuzzy sets [type-1 fuzzy set (T1FS)] for modeling words, only few of them have dealt with ...
Viallet Guilhem G Department of Mechanical Engineering, École de Technologie Supérieure, 1100 rue Notre-Dame Ouest, Montréal, Québec, H3C 1K3, - - 2014
Acoustical test fixtures (ATFs) are currently used to measure the attenuation of the earplugs. Several authors pointed out that the presence of an artificial skin layer inside the cylindrical ear canal of the ATFs strongly influenced the attenuation measurements. In this paper, this role is investigated via a 2D axisymmetric ...
Richard Reg R From the *United States Army Institute of Surgical Research, Sam Houston, Texas; and †SAGE Diagram LLC, Portland, - - 2014
A burn body diagram (BBD) is a common feature used in the delivery of burn care for estimating the TBSA burn as well as calculating fluid resuscitation and nutritional requirements, wound healing, and rehabilitation intervention. However, little change has occurred for over seven decades in the configuration of the BBD. ...
Kilgus Thomas T Computer-Assisted Interventions, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 , Heidelberg, Germany, - - 2014
During autopsy, forensic pathologists today mostly rely on visible indication, tactile perception and experience to determine the cause of death. Although computed tomography (CT) data is often available for the bodies under examination, these data are rarely used due to the lack of radiological workstations in the pathological suite. The ...
Chen Kun - - 2014
In this paper, we propose an improved subtraction algorithm for rapid recovery of Raman spectra that can substantially reduce the computation time. This algorithm is based on an improved Savitzky-Golay (SG) iterative smoothing method, which involves two key novel approaches: (a) the use of the Gauss-Seidel method and (b) the introduction of ...
Bach Dominik R DR Department of Psychiatry, Psychotherapy, and Psychosomatics, University of Zurich, Switzerland; Wellcome Trust Centre for Neuroimaging, University College London, United Kingdom. Electronic address: - - 2014
Model-based analysis of skin conductance responses (SCR) can furnish less noisy estimates of sympathetic arousal (SA) than operational peak scoring approaches, as I have shown in previous work. Here, I provide a direct head-to-head comparison of two model-based methods for analysis of evoked (stimulus-locked) SA, implemented in two software packages, ...
Sheehan Nuala A NA Department of Health Sciences, University of Leicester, UK. Electronic address: - - 2014
The reconstruction of pedigrees from genetic marker data is relevant to a wide range of applications. Likelihood-based approaches aim to find the pedigree structure that gives the highest probability to the observed data. Existing methods either entail an exhaustive search and are hence restricted to small numbers of individuals, or ...
Stanton Robert R Centre for Mental Health Nursing Innovation, Institute for Health and Social Science Research, School of Nursing and Midwifery, Central Queensland University, Bruce Highway Rockhampton QLD 4702, Australia. Electronic address: - - 2014
The activPAL accelerometer is a commonly used device for the assessment of physical activity in cross-sectional and intervention research. These devices are usually attached directly to the skin; however, recent studies report problems such as skin irritation associated with this attachment method and therefore adequate alternate methods are needed. The ...
Guo Chengan - - 2014
Finding the optimal solution to the constrained l0-norm minimization problems in the recovery of compressive sensed signals is an NP-hard problem and it usually requires intractable combinatorial searching operations for getting the global optimal solution, unless using other objective functions (e.g., the l 1 norm or lp norm) for approximate ...
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