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Cvijovic Marija M Department of Mathematical Sciences, Chalmers University of Technology and University of Gothenburg, Chalmers Tvärgata 3, 412 96, Göteborg, Sweden, - - 2014
Systems biology aims at creating mathematical models, i.e., computational reconstructions of biological systems and processes that will result in a new level of understanding-the elucidation of the basic and presumably conserved "design" and "engineering" principles of biomolecular systems. Thus, systems biology will move biology from a phenomenological to a predictive ...
Na Hyuntae H Department of Computer Science, Ames, IA, 50011, - - 2014
Normal mode analysis (NMA) has been a powerful tool for studying protein dynamics. Elastic network models (ENM), through their simplicity, have made normal mode computations accessible to a much broader research community and for many more bio-molecular systems. The drawback of ENMs, however, is that they are less accurate than ...
Qi Xin-Shuai - - 2014
In East Asia, an increasing number of studies on temperate forest tree species find evidence for migration and gene exchange across the East China Sea (ECS) land bridge up until the last glacial maximum (LGM). However, it is less clear when and how lineages diverged in this region, whether in ...
Byrne Michael E ME Warnell School of Forestry and Natural Resources, University of Georgia, Athens, GA, 30602, - - 2014
1.Accurately describing animal space use is vital to understanding how wildlife use habitat. Improvements in GPS technology continue to facilitate collection of telemetry data at high spatial and temporal resolutions. Application of the recently introduced dynamic Brownian bridge movement model (dBBMM) to such data is promising as the method explicitly ...
Baker K H KH School of Biological and Biomedical Sciences, Durham University, Durham, - - 2014
Extant patterns of population structure and levels of diversity are a consequence of factors that vary in both space and time. Our objective in this study is to investigate a species that has responded to both natural and anthropogenic changes in ways that have shaped modern populations and provide insight ...
Yamada Toshihiro T School of Natural System, College of Science and Engineering, Kanazawa University, Kanazawa, 920-1192, Japan, - - 2014
Extant pines of subsection Pinus (section Pinus, genus Pinus, Pinaceae) are predominantly distributed in Eastern Asia. However, the extent of diversification in the section has yet to be fully clarified. We reviewed fossil records of subsection Pinus from Japan and collected permineralized materials, in which anatomical details are preserved for ...
Cámara-Leret Rodrigo R Departamento de Biología, Universidad Autónoma de Madrid, Madrid, - - 2014
A main objective of ethnobotany is to document traditional knowledge about plants before it disappears. However, little is known about the coverage of past ethnobotanical studies and thus about how well the existing literature covers the overall traditional knowledge of different human groups. To bridge this gap, we investigated ethnobotanical ...
Deng Xinyang X 0000-0002-9745-7618 School of Computer and Information Science, Southwest University, Chongqing 400715, - - 2014
Bridge condition assessment is a complex problem influenced by many factors. The uncertain environment increases more its complexity. Due to the uncertainty in the process of assessment, one of the key problems is the representation of assessment results. Though there exists many methods that can deal with uncertain information, however, ...
Akram Muhammad M 0000-0001-7217-7962 Department of Mathematics, University of the Punjab, New Campus, P.O. Box No. 54590, Lahore, - - 2014
Connectivity has an important role in neural networks, computer network, and clustering. In the design of a network, it is important to analyze connections by the levels. The structural properties of intuitionistic fuzzy graphs provide a tool that allows for the solution of operations research problems. In this paper, we ...
Arbisi Paul A PA a Minneapolis VA Health Care System , Minneapolis , - - 2013
In this Special Section, 7 studies focusing on the PSY-5 model of individual differences relevant to adaptive functioning are presented. The first study by Harkness, McNulty, et al. (this issue) describes the development of the revised PSY-5 scales for the MMPI-2-RF, followed by another article by Harkness, Reynolds, and Lilienfeld (this ...
Yun Hae-Bum HB Department of Civil, Environmental and Construction Engineering, University of Central Florida, Orlando, FL 32816, - - 2013
This paper presents the bridge cable inspection robot developed in Korea. Two types of the cable inspection robots were developed for cable-suspension bridges and cable-stayed bridge. The design of the robot system and performance of the NDT techniques associated with the cable inspection robot are discussed. A review on recent ...
Scognamiglio J - - 2013
A toxicologic and dermatologic review of 2-cyclohexyl-1,6-heptadien-3-one when used as a fragrance ingredient is presented. 2-Cyclohexyl-1,6-heptadien-3-one is a member of the fragrance structural group Alkyl Cyclic Ketones. These fragrances can be described as being composed of an alkyl, R1, and various substituted and bicyclic saturated or unsaturated cyclic hydrocarbons, R2, ...
Wang Li - - 2013
A slackening to zero tension by large length release (~20 %) and a restretch of active muscle fibres cause a fall and a redevelopment in tension. According to the model of Brenner (Proc Natl Acad Sci USA 85(9):3265-3269, 1988), the rate constant of tension redevelopment (k TR) is the sum of ...
Alschuler Daniel M - - 2013
EEG topographies may be distorted by electrode bridges, typically caused by electrolyte spreading between adjacent electrodes. We therefore sought to determine the prevalence of electrode bridging and its potential impact on the EEG literature. Five publicly-available EEG datasets were evaluated for evidence of bridging using a new screening method that ...
Carmody Jennifer J - - 2013
Billings Clinic learned the following important lessons in implementing a pharmacy revenue integrity initiative: Integrate pharmacy data as fully as possible. Audit and review pharmacy data regularly to validate the data and identify key areas where education can be provided to support accuracy and compliance. Use technology to bridge gaps ...
Lello Joanne - - 2013
A transmission model clarifies the effects of influenza on pneumococcal pneumonia and bridges the gap between individual animal experiments and human epidemiological data (Shrestha et al., this issue).
Wang Zhen - - 2013
Robust aerogels derived from a thiol-ene clicked bridged silsesquioxane precursor are obtained by a facile vacuum-drying method. With rather low densities, the flexible aerogels are still robust enough to bear at least 20 times repeating compressions and further functionalization by wet doping. The durability and facile preparation procedure promise the ...
Potter Kristen A - - 2013
Despite decades of work on climate change biology, the scientific community remains uncertain about where and when most species distributions will respond to altered climates. A major barrier is the spatial mismatch between the size of organisms and the scale at which climate data are collected and modeled. Using a ...
Cagan Ross L - - 2013
To better translate basic research findings into the clinic, we are moving away from the traditional one-gene-one-phenotype model towards the discovery of complex mechanisms. In this Editorial, the new Editor-in-Chief and Senior Editors of Disease Models & Mechanisms (DMM) discuss the role that the journal will play in this transition. ...
Schellekens Elisabeth - - 2013
In the context of a broad welcome to Bullot & Reber's (B&R's) proposals concerning the incorporation of contextual awareness into the study of the psychology of art appreciation, I raise two concerns. First, the proposal makes no allowance for degrees of relevance of contextual awareness to appreciation. Second, the authors ...
Lux Andrew L - - 2013
Infantile spasms remain a challenging condition to study and treat, and although they form the commonest epilepsy syndrome with onset in infancy, the challenge is broadened by the wide range of potential underlying causes. The field of study remains dynamic, with debates relating to case definitions and organising structures for ...
Garnier Simon - - 2013
Robustness and adaptability are central to the functioning of biological systems, from gene networks to animal societies. Yet the mechanisms by which living organisms achieve both stability to perturbations and sensitivity to input are poorly understood. Here, we present an integrated study of a living architecture in which army ants ...
Fraser James S JS Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA 94158, USA. - - 2013
There is a wide gap between the generation of large-scale biological data sets and more-detailed, structural and mechanistic studies. However, recent studies that explicitly combine data from systems and structural biological approaches are having a profound effect on our ability to predict how mutations and small molecules affect atomic-level mechanisms, ...
Galanopoulou Aristea S - - 2013
Infantile spasms are age-specific seizures of infantile epileptic encephalopathies that are usually associated with poor epilepsy and neurodevelopmental outcomes. The current treatments are not always effective and may be associated with significant side effects. Various mechanisms have been proposed as pathogenic for infantile spasms, including cortical or brainstem dysfunction, disruption ...
Lan Yueheng - - 2013
Transitions between different condensed phases, molecular conformations, chemical compositions, or spatiotemporal patterns play important roles in many branches of natural science and at the same time incur serious challenges in their precise characterization. We design an approach for computing connecting orbits bridging steady states based on the renormalization group analysis. ...
Spjuth Ola - - 2013
The InChI algorithms are written in C++ and not available as Java library. Integration into software written in Java therefore requires a bridge between C and Java libraries, provided by the Java Native Interface (JNI) technology. We here describe how the InChI library is used in the Bioclipse workbench and ...
Talluri Rajesh - - 2013
Rare variants have increasingly been cited as major contributors in the disease etiology of several complex disorders. Recently, several approaches have been proposed for analyzing the association of rare variants with disease. These approaches include collapsing rare variants, summing rare variant test statistics within a particular locus to improve power, ...
Evinger Craig - - 2013
The focal dystonia benign essential blepharospasm (BEB) affects as many as 40,000 individuals in the United States. This dystonia is characterized by trigeminal hyperexcitability, photophobia, and most disabling of the symptoms, involuntary spasms of lid closure that can produce functional blindness. Like many focal dystonias, BEB appears to develop from ...
Liu Wenjia - - 2013
This paper investigates the time series representation methods and similarity measures for sensor data feature extraction and structural damage pattern recognition. Both model-based time series representation and dimensionality reduction methods are studied to compare the effectiveness of feature extraction for damage pattern recognition. The evaluation of feature extraction methods is ...
Jiao Yubo - - 2013
Performance evaluation of a bridge is critical for determining the optimal maintenance strategy. An unsupervised bridge superstructure state assessment method is proposed in this paper based on fuzzy clustering and bridge field measured data. Firstly, the evaluation index system of bridge is constructed. Secondly, a certain number of bridge health ...
Swenson Kristine - - 2013
Silas Weir Mitchell's novel, When All the Woods are Green (1894), acknowledges the medical use of mindblindness (agnosia) but also casts it as a developmental disorder, bringing it provocatively close to how current neuropsychologist, Simon Baron-Cohen and his followers use the term in relation to autism. This chapter traces the ...
Gong Kai K Web Sciences Center, University of Electronic Science and Technology of China, Chengdu, People's Republic of China ; Department of Physics, The Chinese University of Hong Kong, Shatin, Hong Kong, People's Republic of - - 2013
An efficient algorithm that can properly identify the targets to immunize or quarantine for preventing an epidemic in a population without knowing the global structural information is of obvious importance. Typically, a population is characterized by its community structure and the heterogeneity in the weak ties among nodes bridging over ...
Armagan Artin A SAS Institute Inc., Durham, NC 27513, USA, - - 2013
We propose a generalized double Pareto prior for Bayesian shrinkage estimation and inferences in linear models. The prior can be obtained via a scale mixture of Laplace or normal distributions, forming a bridge between the Laplace and Normal-Jeffreys' priors. While it has a spike at zero like the Laplace density, ...
Shu Panpan - - 2012
Weak ties play a significant role in the structures and the dynamics of community networks. Based on the contact process, we study numerically how weak ties influence the predictability of epidemic dynamics. We first investigate the effects of the degree of bridge nodes on the variabilities of both the arrival ...
Schwab David J DJ Department of Molecular Biology and Physics, Princeton University, Princeton, New Jersey 08854, - - 2012
Synchronization of coupled oscillators is often described using the Kuramoto model. Here, we study a generalization of the Kuramoto model where oscillators communicate with each other through an external medium. This generalized model exhibits interesting new phenomena such as bistability between synchronization and incoherence and a qualitatively new form of ...
Eliasmith Chris - - 2012
A central challenge for cognitive and systems neuroscience is to relate the incredibly complex behavior of animals to the equally complex activity of their brains. Recently described, large-scale neural models have not bridged this gap between neural activity and biological function. In this work, we present a 2.5-million-neuron model of ...
Aihara Jun-Ichi - - 2012
According to the bridged annulene model, macrocyclic aromaticity of a porphyrinoid species can be attributed to the annulene-like main macrocyclic conjugation pathway (MMCP). Macrocyclic aromaticity, however, is given theoretically as a sum of contributions from all macrocyclic circuits. We found that the aromaticity due to each macrocyclic circuit is determined ...
Mahl Dominik - - 2012
Markov models are mathematical models that can be used to describe disease progression and evaluate the cost-effectiveness of medical interventions. Markov models allow projecting clinical and economic outcomes into the future and are therefore frequently used to estimate long-term outcomes of medical interventions. The purpose of this paper is to ...
Cameron Delroy D Ohio Center of Excellence in Knowledge-enabled Computing (Kno.e.sis), Wright State University, Dayton, OH 45435, USA. - - 2013
This paper presents a methodology for recovering and decomposing Swanson's Raynaud Syndrome-Fish Oil hypothesis semi-automatically. The methodology leverages the semantics of assertions extracted from biomedical literature (called semantic predications) along with structured background knowledge and graph-based algorithms to semi-automatically capture the informative associations originally discovered manually by Swanson. Demonstrating that ...
Forsea A M - - 2012
Melanoma incidence and mortality in Europe are high but there are significant gaps in the epidemiological information available across the continent. With the aim of enhancing the planning of educational programmes for reducing the melanoma burden in Europe, we analysed the most recent incidence and mortality data for Europe with ...
Chow Shein-Chung - - 2012
In 1998, the International Conference on Harmonization (ICH) published a guidance to facilitate the registration of medicines among ICH regions including the European Union, the United States, and Japan by recommending a framework for evaluating the impact of ethnic factors on a medicine's effect, such as its efficacy and safety ...
Gandhi Mihir - - 2012
To address concerns that ethnic differences in any clinical trial may affect the performance of a treatment, separate clinical trials may be required for different regions. If a drug is approved in one region based on a bigger clinical trial, a bridging study with smaller size may be conducted in ...
Tsou Hsiao-Hui - - 2012
The ICH E5 Guidance facilitates the registration of medicine among ICH regions by recommending a framework for evaluating the impact of ethnic factors upon a medicine's effect. It further describes the use of bridging studies, when necessary, to allow extrapolation of foreign clinical data to a new region. Bridging studies ...
Bande Rodríguez M F - - 2012
PURPOSE: The uveal melanoma is the most common primary intraocular tumour in adults. The objective of this work is to show how a computerised database has been formed with specific applications, for clinical and research use, to an extensive group of patients diagnosed with uveal melanoma. METHOD: For the design ...
Clark Kari - - 2012
Implementing a standardized financial reporting and revenue cycle monitoring platform can help healthcare organizations improve their net revenue reporting and budgeting processes. Consistent, standardized data help the finance office estimate accounts receivable reserves more accurately, streamline the month-end closing process, and strengthen internal controls. The benefits of standardizing the finance ...
Radi Marco - - 2012
A combined targeted/phenotypic approach for the rapid identification of novel antiangiogenics with in vivo efficacy is herein reported. Considering the important role played by the tyrosine kinase c-Src in the regulation of tumour angiogenesis, we submitted our in-house library of c-Src inhibitors to a sequential screening approach: in silico screening ...
Gibot Laure - - 2012
Cutaneous malignant melanomas represent an important clinical problem because they are highly invasive, they can metastasize to distant sites and are typically resistant to available therapy. The precise molecular determinants responsible for melanoma progression and chemo-resistance are not yet known, in part due to lack of pertinent experimental models that ...
Magnitsky S S Laboratory of Molecular Imagintg, Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, - - 2013
This study compared the steady state concentration of lactate in an inducible Her2/nue transgenic breast cancer mouse model and in tumours from the same Her2/neu model grown orthotopically. In vivo lactate was detected by MRS using the Hadamard encoded selective multiple quantum coherence pulse sequence (HadSelMQC) recently developed by our ...
Parodi S - - 2012
In Clinical Epidemiology, receiver operating characteristic (ROC) analysis is a standard approach for the evaluation of the performance of diagnostic tests for binary classification based on a tumour marker distribution. The area under a ROC curve is a popular indicator of test accuracy, but its use has been questioned when ...
Lesart Anne-Cécile - - 2012
A computational model is potentially a powerful tool to apprehend complex phenomena like solid tumour growth and to predict the outcome of therapies. To that end, the confrontation of the model with experiments is essential to validate this tool. In this study, we develop a computational model specifically dedicated to ...
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