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Fakhraei Shobeir S Medical Image Analysis Laboratory, Department of Radiology, Henry Ford Health System, Detroit, MI 48202, USA ; Department of Computer Science, University of Maryland, College Park, MD 20740, - - 2014
Feature rankings are often used for supervised dimension reduction especially when discriminating power of each feature is of interest, dimensionality of dataset is extremely high, or computational power is limited to perform more complicated methods. In practice, it is recommended to start dimension reduction via simple methods such as feature ...
Kevric Jasmin J Department of Electrical and Electronics Engineering, International Burch University, Sarajevo, 71000, Bosnia and Herzegovina, - - 2014
In this paper we describe the effect of Multiscale Principal Component Analysis (MSPCA) de-noising method in terms of epileptic seizure detection. In addition, we developed a patient-independent seizure detection algorithm using Freiburg EEG database. Each patient contains datasets called "ictal" and "interictal". Window length of 16 s was applied to extract ...
Cheung Carol C CC 1] Department of Pathology, Laboratory Medicine Program, University Health Network, Toronto, ON, Canada [2] Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, ON, - - 2014
Pathologists provide diagnoses relevant to the disease state of the patient and identify specific tissue characteristics relevant to response to therapy and prognosis. As personalized medicine evolves, there is a trend for increased demand of tissue-derived parameters. Pathologists perform increasingly complex analyses on the same 'cases'. Traditional methods of workload ...
Moolchandani Vikas V School of Pharmacy, University of Maryland , Baltimore, MD , USA - - 2014
Abstract The purpose of this work is to characterize thermal, physical and mechanical properties of different grades of lactose and better understand the relationships between these properties and capsule filling performance. Eight grades of commercially available lactose were evaluated: Pharmatose 110 M, 125 M, 150 M, 200 M, 350 M (α-lactose monohydrate), AL (anhydrous lactose ...
Tuccinardi Tiziano - - 2014
Molecular docking strategy is one of the most wide used techniques for predicting the binding mode of a ligand and for obtaining new hits in virtual screening studies. In order to improve the accuracy of this approach, we tested the reliability of applying a consensus docking protocol by combining ten ...
Neto David D DD Faculdade de Psicologia, Universidade de Lisboa, Portugal; The School of Health and Related Research, University of Sheffield, - - 2014
Assimilation is an important process in understanding change in psychotherapy. Similar to other psychological processes, assimilation may be traceable in the speech of clients by attending to its signs or indices. In the present research, we aimed to build a system of indices of assimilation. This research follows a mixed ...
Huang A A Department of Electrical and Computer Engineering, University of Miami, Coral Gables, FL, - - 2014
In multiple quantitative trait locus (QTL) mapping, a high-dimensional sparse regression model is usually employed to account for possible multiple linked QTLs. The QTL model may include closely linked and thus highly correlated genetic markers, especially when high-density marker maps are used in QTL mapping because of the advancement in ...
Chen Zhen - - 2014
Protein ubiquitination is one of the most important reversible post-translational modifications (PTMs). In many biochemical, pathological and pharmaceutical studies on understanding the function of proteins in biological processes, identification of ubiquitination sites is an important first step. However, experimental approaches for identifying ubiquitination sites are often expensive, labor-intensive and time-consuming, ...
Thuiller Wilfried W Univ. Grenoble Alpes, Laboratoire d'Écologie Alpine (LECA), F-38000, Grenoble, France; CNRS, Laboratoire d'Écologie Alpine (LECA), F-38000, Grenoble, - - 2014
The need for anticipating and mitigating the potential effects of climate change on biodiversity has triggered the development of predictive tools to provide quantitative scenarios to guide decision making (Pereira et al., 2010). Notably, the recently established 'Intergovernmental Platform on Biodiversity and Ecosystem Services' (IPBES) will rely on these predictive tools. ...
Quinn Jamie M JM Florida State - - 2014
The present study followed a sample of first-grade (N = 316, Mage  = 7.05 at first test) through fourth-grade students to evaluate dynamic developmental relations between vocabulary knowledge and reading comprehension. Using latent change score modeling, competing models were fit to the repeated measurements of vocabulary knowledge and reading comprehension to test for ...
Rivas-Perea Pablo - - 2014
Leukocoria is defined as a white reflection from the retina of the eye and its manifestation is symptomatic of several ocular pathologies, including retinoblastoma (Rb). Early detection of recurrent leukocoria is critical for improved patient outcomes and can be accomplished via the examination of recreational photography. To date, there exists ...
Ganjtabesh Mohammad M Department of Computer Science, School of Mathematics Statistics and Computer Science, University of Tehran, Tehran, Iran. Electronic address: - - 2014
Motivation: Interaction of two RNA molecules is considered as an important factor that regulates gene expression post-transcriptional process. Most of the ncRNAs prevent the translation of their target mRNA(s) by forming stable bindings with them. Although several computational methods have been proposed to predict the interactions between two RNAs, none ...
Eng Simon W M SW University of Toronto, Toronto, Ontario, Canada; The Hospital for Sick Children, Toronto, Ontario, - - 2014
Objective. Childhood arthritis encompasses a heterogeneous family of diseases. Significant variation in clinical presentation remains despite consensus-driven diagnostic classifications. Developments in data analysis provide powerful tools for interrogating large heterogeneous datasets. We report a novel approach to integrate biologic and clinical data towards a new classification for childhood arthritis, employing ...
Moreno-Bote Rubén R 1] Research Unit, Parc Sanitari Sant Joan de Déu and Universitat de Barcelona, Esplugues de Llobregat, Barcelona, Spain. [2] Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Esplugues de Llobregat, Barcelona, - - 2014
Computational strategies used by the brain strongly depend on the amount of information that can be stored in population activity, which in turn strongly depends on the pattern of noise correlations. In vivo, noise correlations tend to be positive and proportional to the similarity in tuning properties. Such correlations are ...
Roy Kunal - - 2014
The central axiom of science purports the explanation of every natural phenomenon using all possible logics coming from pure as well as mixed scientific background. The quantitative structure-activity relationship (QSAR) analysis is a study correlating the behavioral manifestation of compounds with their structures employing the interdisciplinary knowledge of chemistry, mathematics, ...
Lee George - - 2014
In this work, we present a new methodology to facilitate prediction of recurrent prostate cancer (CaP) following radical prostatectomy (RP) via the integration of quantitative image features and protein expression extracted from the excised prostate. Creating a fused predictor from big data streams comprised of thousands of dimensions is challenged ...
Edward Jero S S Department of Engineering Design, Indian Institute of Technology Madras, Chennai, India, - - 2014
ECG Steganography provides secured transmission of secret information such as patient personal information through ECG signals. This paper proposes an approach that uses discrete wavelet transform to decompose signals and singular value decomposition (SVD) to embed the secret information into the decomposed ECG signal. The novelty of the proposed method ...
Lohumi Santosh - - 2014
Adulteration of onion powder with cornstarch was identified by Fourier transform near-infrared (FT-NIR) and Fourier transform infrared (FT-IR) spectroscopy. The reflectance spectra of 180 pure and adulterated samples (1-35 wt% starch) were collected and preprocessed to generate calibration and prediction sets. A multivariate calibration model of partial least-squares regression (PLSR) ...
Iván Gábor G PIT Bioinformatics Group, Eötvös University, Pázmány Péter stny. 1/C, H-1117 Budapest, Hungary; Uratim Ltd., H-1118 Budapest, Hungary. Electronic address: - - 2014
OPTICS is a density-based clustering algorithm that performs well in a wide variety of applications. For a set of input objects, the algorithm creates a reachability plot that can either be used to produce cluster membership assignments, or interpreted itself as an expressive two-dimensional representation of the clustering structure of ...
Wright Kristin A KA Department of Anatomy, Kansas City University of Medicine and Biosciences, Kansas City, MO, USA. Electronic address: - - 2014
Recent molecular work has confirmed the long-standing morphological hypothesis that capuchins are comprised of two distinct clades, the gracile (untufted) capuchins (genus Cebus, Erxleben, 1777) and the robust (tufted) capuchins (genus Sapajus Kerr, 1792). In the past, the robust group was treated as a single, undifferentiated and cosmopolitan species, with ...
Paquette Cherie C *Department of Pathology and Laboratory Medicine, University of Virginia Health System ‡Department of Health Evaluation Sciences, University of Virginia School of Medicine, Charlottesville, VA †Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, - - 2014
A histologic pattern-based system of risk stratification for endocervical adenocarcinoma has been recently proposed on the basis of tumor-stroma interface and lymph-vascular invasion. The key utility of the system lies in separating cases with very low risk for nodal metastases (pattern A) from those with higher risk (patterns B and ...
Mohammed Osama O Department of Software Engineering, Lakehead University, 955 Oliver Road, Thunder Bay, P7B 5E1, ON, Canada, - - 2014
In this paper we describe a novel model for differential diagnosis designed to make recommendations by utilizing semantic web technologies. The model is a response to a number of requirements, ranging from incorporating essential clinical diagnostic semantics to the integration of data mining for the process of identifying candidate diseases ...
Pomyen Yotsawat Y Section of Computational and Systems Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, Exhibition Road, London SW7 2AZ, UK. Translational Research Unit, Chulabhorn Research Institute, Bangkok 10210, Thailand. - - 2014
Often during the analysis of biological data it is of importance to interpret the correlation structure that exists between variables. Such correlations may reveal patterns of co-regulation that are indicative of biochemical pathways or common mechanisms of response to a related set of treatments. However analyses of correlations are usually ...
Sharma Mukesh C MC Drug Research Laboratory, School of Pharmacy, Devi Ahilya University, Takshila Campus, Khandwa Road, Indore, (M.P), 452001, India, - - 2014
The present study is aimed to elucidate the structural features of substituted 2-(1-propylpiperidin-4-yl)-1H-benzimidazole-4-carboxamide required for poly (ADP-ribose) polymerase inhibition and to obtain predictive 2D QSAR models to guide the rational synthesis of novel poly (ADP-ribose) polymerase inhibitors. The statistical analysis has shown that excellent results are obtained by using partial ...
Coelho Neto Marcela A MA Department of Obstetrics and Gynecology, Medical School of Ribeirao Preto, University of Sao Paulo (DGO-FMRP-USP), Ribeirao Preto, - - 2014
To examine the quality of the methods and accuracy of the interpretation from the existing studies examining the reliability of ultrasound measurements and judgments in obstetrics and gynecology. We performed a systematic review in MEDLINE on Mar-25-2014 searching for studies examining reliability of ultrasound measurements and judgments in obstetrics and ...
Perry Samuel Charles - - 2014
In sampled-current voltammetry (SCV) current transients acquired after stepping the potential along the redox wave of interest are sampled at a fixed time to produce a sigmoidal current-potential curve akin to a pseudo steady state voltammogram. Repeating the sampling for different times yields a family of sampled-current voltammograms, one for ...
Subtil Fabien F Université de Lyon, Lyon, France Université Lyon 1, Villeurbanne, France CNRS, UMR5558, Laboratoire de Biométrie et Biologie Evolutive, Villeurbanne, France Hospices Civils de Lyon, Service de Biostatistique, Lyon, France - - 2014
Classifying patients according to longitudinal measures, or trajectory classification, has become frequent in clinical research. The k-means algorithm is increasingly used for this task in case of continuous variables with standard deviations that do not depend on the mean. One feature of count and binary data modeled by Poisson or ...
Stanculescu Ioan - - 2014
Late onset neonatal sepsis is one of the major clinical concerns when premature babies receive intensive care. Current practice relies on slow laboratory testing of blood cultures for diagnosis. A valuable research question is whether sepsis can be reliably detected before the blood sample is taken. This paper investigates the ...
Chen Yun-Ching YC Department of Biomedical Engineering and Institute for Computational Medicine, The Johns Hopkins University, Baltimore, Maryland, United States of - - 2014
Genetic screening is becoming possible on an unprecedented scale. However, its utility remains controversial. Although most variant genotypes cannot be easily interpreted, many individuals nevertheless attempt to interpret their genetic information. Initiatives such as the Personal Genome Project (PGP) and Illumina's Understand Your Genome are sequencing thousands of adults, collecting ...
Kim Yongsoo Y School of Interdisciplinary Bioscience and Bioengineering and Department of Computer Science and Engineering, Pohang University of Science and Technology, Pohang 790-784, Korea and Department of New Biology and Center for Plant Aging Research, Institute for Basic Science, Daegu Gyeongbuk Institute of Science and Technology, Daegu 711-873, - - 2014
Time-evolving differential protein-protein interaction (PPI) networks are essential to understand serial activation of differentially regulated (up- or downregulated) cellular processes (DRPs) and their interplays over time. Despite developments in the network inference, current methods are still limited in identifying temporal transition of structures of PPI networks, DRPs associated with the ...
Schork Ivana Gabriela IG Conservation, Ecology and Animal Behaviour Group, Prédio 41, Mestrado em Zoologia, Pontifícia Universidade Católica de Minas Gerais, Avenida Dom José Gaspar, 500, Coração Eucarístico, 30535-610 Belo Horizonte, Minas Gerais, - - 2014
The welfare of an individual depends on its capacity to overcome suboptimal conditions in its environment; otherwise, its physical and psychological health becomes compromised. A situation that clearly indicates lack of control of the environment is the expression of abnormal behaviours, such as stereotypies. This study aimed to verify the ...
Bartolitius Lennart - - 2014
A nose model that allows for the comparison of different modes of sample acquisition as well as of nasal swab systems concerning their suitability to detect defined quantities of intranasal microorganisms, and further for training procedures of medical staff, was evaluated. Based on an imprint of a human nose, a ...
Dubecký Matúš M Regional Centre of Advanced Technologies and Materials, Department of Physical Chemistry, Faculty of Science, Palacký University Olomouc, tř. 17 listopadu 12, 771 46 Olomouc, Czech Republic. matus.dubecky@upol.cz - - 2014
Reliable theoretical prediction of noncovalent interaction energies, which are important e.g. in drug-design and hydrogen-storage applications, is one of the longstanding challenges of contemporary quantum chemistry. In this respect, the fixed-node diffusion Monte Carlo (FN-DMC) method is a promising alternative to the commonly used "gold standard" coupled-cluster CCSD(T)/CBS method due ...
Marty Roman - - 2014
Vibrational circular dichroism (VCD) spectroscopy has become an excellent tool to study biological nanostructures and biomimetic materials in their functional environment and is thus complementary to otherwise employed diffraction, imaging, and spectroscopy methods. However, it is still difficult to relate the observed exceptionally large VCD signals to specific structural elements. ...
Gusareva Elena S ES Systems and Modeling Unit, Montefiore Institute, University of Liege, 10 Grande Traverse, Sart-Tilman, 4000, Liège, Belgium, - - 2014
Large-scale epistasis studies can give new clues to system-level genetic mechanisms and a better understanding of the underlying biology of human complex disease traits. Though many novel methods have been proposed to carry out such studies, so far only a few of them have demonstrated replicable results. Here, we propose ...
Reichenbach P P Consiglio Nazionale delle Ricerche, Istituto di Ricerca per la Protezione Idrogeologica, Perugia, Italy, - - 2014
The spatial distribution of landslides is influenced by different climatic conditions and environmental settings including topography, morphology, hydrology, lithology, and land use. In this work, we have attempted to evaluate the influence of land use change on landslide susceptibility (LS) for a small study area located in the southern part ...
Kadalayil Latha - - 2014
Copy number variants (CNVs) play important roles in a number of human diseases and in pharmacogenetics. Powerful methods exist for CNV detection in whole genome sequencing (WGS) data, but such data are costly to obtain. Many disease causal CNVs span or are found in genome coding regions (exons), which makes ...
Oloumi Faraz F Electrical and Computer Engineering, University of Calgary, 2500 University Dr. NW, Calgary, Alberta, T2N 1N4, - - 2014
Purpose: To test the hypothesis that the openness of the major temporal arcade (MTA) changes in the presence of plus disease, by quantification via parabolic modeling of the MTA, as well as measurement of an arcade angle for comparative analysis. Such analysis could assist in the detection and treatment of ...
Wang Junbai - - 2014
Computational modeling transcription factor (TF) sequence specificity is an important research topic in regulatory genomics. A systematic comparison of 26 algorithms to learn TF-DNA binding specificity in in vitro protein-binding microarray (PBM) data was published recently, but the quality of those examined PBMs was not evaluated completely. Here, new quality-control ...
Heath C A E CA School of Veterinary Sciences,University of Bristol,Langford House,Langford,Bristol,BS40 - - 2014
The Welfare Quality ® protocols provide a multidimensional assessment of welfare, which is lengthy, and hence limited in terms of practicality. The aim of this study was to investigate potential 'iceberg indicators' which could reliably predict the overall classification as a means of reducing the length of time for an ...
Pan Shirui - - 2014
Many applications involve stream data with structural dependency, graph representations, and continuously increasing volumes. For these applications, it is very common that their class distributions are imbalanced with minority (or positive) samples being only a small portion of the \hbox{population}, which imposes significant challenges for learning models to accurately identify ...
Zhao Lei L Centre for Computational Systems Biology, Fudan University, 220 Handan Road, Shanghai, 200433, People's Republic of - - 2014
Forward and backward simulations play an increasing role in population genetics, in particular when inferring the relative importance of evolutionary forces. It is therefore important to develop fast and accurate simulation methods for general population genetics models. Here we present an exact simulation method that generates trajectories of an allele's ...
Sinclair Leanne L 1Sullivan Nicolaides Pathology, Brisbane 2Bond University, Robina, Qld 3PathWest, Perth, WA, - - 2014
This study was designed to create a snapshot of Australian haematology reference intervals (RIs) in use, in particular red cell parameters. We present an analysis of survey results conducted across Australian laboratories between November 2012 and January 2013. All Australian laboratories enrolled in the Royal College of Pathologists of Australasia ...
Huber Christian D CD Max F. Perutz Laboratories, University of Vienna, Vienna, Austria Vienna Graduate School of Population Genetics, Vetmeduni Vienna, Vienna, Austria - - 2014
Detecting positive selection in species with heterogeneous habitats and complex demography is notoriously difficult and prone to statistical biases. The model plant Arabidopsis thaliana exemplifies this problem: in spite of the large amounts of data, little evidence for classic selective sweeps has been found. Moreover, many aspects of the demography ...
- - 2014
Predicting the potential habitat of species under both current and future climate change scenarios is crucial for monitoring invasive species and understanding a species' response to different environmental conditions. Frequently, the only data available on a species is the location of its occurrence (presence-only data). Using occurrence records only, two ...
Jow Howsun - - 2014
Abstract In this paper we develop a Bayesian statistical inference approach to the unified analysis of isobaric labelled MS/MS proteomic data across multiple experiments. An explicit probabilistic model of the log-intensity of the isobaric labels' reporter ions across multiple pre-defined groups and experiments is developed. This is then used to ...
de Bie Johan J Mortara Instrument Inc., 7865 North 86th Street, 53224 Milwaukee, WI, USA. Electronic address: - - 2014
A fraction of routine resting ECG's are taken with electrode positions interchanged, leading to possible clinical misinterpretation. Develop and test a method to detect and prevent electrode reversals at the electrocardiograph before the ECG is acquired. The algorithm is based on QRS axis and P amplitudes for limb electrode reversals, ...
Wu Chaochao - - 2014
Due to their high sensitivity and specificity, selected reaction monitoring (SRM) based targeted proteomics has become increasingly popular for biological and translational applications. Selection of optimal transitions and optimization of collision energy (CE) are important assay development steps for achieving sensitive detection and accurate quantification; however, these steps can be ...
Sandquist Mary M Department of Pediatrics, Division of Critical Care Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229-3039, USA and Cincinnati Children's Hospital Research Foundation, University of Cincinnati College of Medicine, 3333 Burnet Ave, Cincinnati, OH 45229-3039, - - 2014
Biomarkers have great potential to improve the diagnosis and treatment of sepsis. The available literature supports the potential utility of sTREM-1, IL-27, suPAR, neutrophil CD64, presepsin, cfDNA and miRNAs as novel diagnostic, prognostic and treatment response biomarkers. The future of sepsis biomarkers lies in extensive validation studies of such novel ...
Hanson Erin K EK National Center for Forensic Science, PO Box 162367, Orlando, FL, - - 2014
We report the identification of sensitive and specific miRNA biomarkers for menstrual blood, a tissue that might provide probative information in certain specialized instances. We incorporated these biomarkers into qPCR assays and developed a quantitative statistical model using logistic regression that permits the prediction of menstrual blood in a forensic ...
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