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Jow Howsun - - 2014
Abstract In this paper we develop a Bayesian statistical inference approach to the unified analysis of isobaric labelled MS/MS proteomic data across multiple experiments. An explicit probabilistic model of the log-intensity of the isobaric labels' reporter ions across multiple pre-defined groups and experiments is developed. This is then used to ...
Wu Chaochao - - 2014
Due to their high sensitivity and specificity, selected reaction monitoring (SRM) based targeted proteomics has become increasingly popular for biological and translational applications. Selection of optimal transitions and optimization of collision energy (CE) are important assay development steps for achieving sensitive detection and accurate quantification; however, these steps can be ...
Sandquist Mary M Department of Pediatrics, Division of Critical Care Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229-3039, USA and Cincinnati Children's Hospital Research Foundation, University of Cincinnati College of Medicine, 3333 Burnet Ave, Cincinnati, OH 45229-3039, - - 2014
Biomarkers have great potential to improve the diagnosis and treatment of sepsis. The available literature supports the potential utility of sTREM-1, IL-27, suPAR, neutrophil CD64, presepsin, cfDNA and miRNAs as novel diagnostic, prognostic and treatment response biomarkers. The future of sepsis biomarkers lies in extensive validation studies of such novel ...
Hanson Erin K EK National Center for Forensic Science, PO Box 162367, Orlando, FL, - - 2014
We report the identification of sensitive and specific miRNA biomarkers for menstrual blood, a tissue that might provide probative information in certain specialized instances. We incorporated these biomarkers into qPCR assays and developed a quantitative statistical model using logistic regression that permits the prediction of menstrual blood in a forensic ...
Demir Pinar P Department of Biology, Middle East Technical University, 06800 Ankara, - - 2014
Within the last decade, an increasing amount of genetic data has been used to clarify the problems inherent in wheat taxonomy. The techniques for obtaining and analyzing these data are not only cumbersome, but also expensive and technically demanding. In the present study, we introduce infrared spectroscopy as a method ...
Duan Junbo J Department of Biomedical Engineering, Xi'an Jiaotong University, Xi'an, P. R. - - 2014
Copy number variations (CNVs) can be used as significant bio-markers and next generation sequencing (NGS) provides a high resolution detection of these CNVs. But how to extract features from CNVs and further apply them to genomic studies such as population clustering have become a big challenge. In this paper, we ...
Everill Peter H PH Boston University Department of Biology, 5 Cummington Mall, Boston, Massachusetts 02215 - - 2014
• There is great interest in studying leaf-out times of temperate forests because of the importance of leaf-out in controlling ecosystem processes, especially in the face of a changing climate. Remote sensing and modeling, combined with weather records and field observations, are increasing our knowledge of factors affecting variation in ...
Famaey Nele N Biomechanics Section, KU Leuven, Belgium. Electronic address: - - 2014
Bridging veins drain the venous blood from the cerebral cortex into the superior sagittal sinus (SSS) and doing so they bridge the subdural space. Despite their importance in head impact biomechanics, little is known about their properties with respect to histology, morphology and mechanical behaviour. Knowledge of these characteristics is ...
Wang Jing J Department of Pediatrics, General Hospital of Chinese People's Liberation Army, Beijing, - - 2014
Infantile spasms (IS) are an age-dependent epileptic encephalopathy with severe cognitive dysfunction. Prenatal stress (PS) has been reported to increase the risk for IS through clinical and animal studies. We aim to investigate the mechanism of brain damage caused by IS and the effect of PS. Animals were divided into ...
Niemi Milla M Department of Forest Sciences, University of Helsinki, P.O. Box 27, FI-00014, University of Helsinki, Finland. Electronic address: - - 2014
Wildlife passages are widely used mitigation measures designed to reduce the adverse impacts of roads on animals. We investigated whether road kills of small and medium-sized terrestrial vertebrates can be reduced by constructing dry paths adjacent to streams that pass under road bridges. The study was carried out in southern ...
Ring A A Department of Mathematical Statistics and Actuarial Science, University of the Free State, P.O. Box 339 (IB75), Bloemfontein, South Africa, - - 2014
For market approval, new drug formulations (test) must demonstrate bioequivalence (BE) to at least one approved formulation (reference). If several formulations of a drug are already on the market, one might have to show BE to more than one reference formulation. Similarly, if several test formulations have shown BE to ...
Cvijovic Marija M Department of Mathematical Sciences, Chalmers University of Technology and University of Gothenburg, Chalmers Tvärgata 3, 412 96, Göteborg, Sweden, - - 2014
Systems biology aims at creating mathematical models, i.e., computational reconstructions of biological systems and processes that will result in a new level of understanding-the elucidation of the basic and presumably conserved "design" and "engineering" principles of biomolecular systems. Thus, systems biology will move biology from a phenomenological to a predictive ...
Na Hyuntae H Department of Computer Science, Ames, IA, 50011, - - 2014
Normal mode analysis (NMA) has been a powerful tool for studying protein dynamics. Elastic network models (ENM), through their simplicity, have made normal mode computations accessible to a much broader research community and for many more bio-molecular systems. The drawback of ENMs, however, is that they are less accurate than ...
Byrne Michael E ME Warnell School of Forestry and Natural Resources, University of Georgia, Athens, GA, 30602, - - 2014
1.Accurately describing animal space use is vital to understanding how wildlife use habitat. Improvements in GPS technology continue to facilitate collection of telemetry data at high spatial and temporal resolutions. Application of the recently introduced dynamic Brownian bridge movement model (dBBMM) to such data is promising as the method explicitly ...
Baker K H KH School of Biological and Biomedical Sciences, Durham University, Durham, - - 2014
Extant patterns of population structure and levels of diversity are a consequence of factors that vary in both space and time. Our objective in this study is to investigate a species that has responded to both natural and anthropogenic changes in ways that have shaped modern populations and provide insight ...
Yamada Toshihiro T School of Natural System, College of Science and Engineering, Kanazawa University, Kanazawa, 920-1192, Japan, - - 2014
Extant pines of subsection Pinus (section Pinus, genus Pinus, Pinaceae) are predominantly distributed in Eastern Asia. However, the extent of diversification in the section has yet to be fully clarified. We reviewed fossil records of subsection Pinus from Japan and collected permineralized materials, in which anatomical details are preserved for ...
Cámara-Leret Rodrigo R Departamento de Biología, Universidad Autónoma de Madrid, Madrid, - - 2014
A main objective of ethnobotany is to document traditional knowledge about plants before it disappears. However, little is known about the coverage of past ethnobotanical studies and thus about how well the existing literature covers the overall traditional knowledge of different human groups. To bridge this gap, we investigated ethnobotanical ...
Deng Xinyang X 0000-0002-9745-7618 School of Computer and Information Science, Southwest University, Chongqing 400715, - - 2014
Bridge condition assessment is a complex problem influenced by many factors. The uncertain environment increases more its complexity. Due to the uncertainty in the process of assessment, one of the key problems is the representation of assessment results. Though there exists many methods that can deal with uncertain information, however, ...
Akram Muhammad M 0000-0001-7217-7962 Department of Mathematics, University of the Punjab, New Campus, P.O. Box No. 54590, Lahore, - - 2014
Connectivity has an important role in neural networks, computer network, and clustering. In the design of a network, it is important to analyze connections by the levels. The structural properties of intuitionistic fuzzy graphs provide a tool that allows for the solution of operations research problems. In this paper, we ...
Qi Xin-Shuai - - 2014
In East Asia, an increasing number of studies on temperate forest tree species find evidence for migration and gene exchange across the East China Sea (ECS) land bridge up until the last glacial maximum (LGM). However, it is less clear when and how lineages diverged in this region, whether in ...
Wagner Nils-Frederic NF Royal Ottawa Health Care Group, Mind, Brain Imaging and Neuroethics, Institute of Mental Health Research, University of Ottawa Ottawa, ON, Canada ; Taipei Medical University-Shuang Ho Hospital, Brain and Consciousness Research Center New Taipei City, - - 2014
In philosophy, the criteria for personhood (PH) at a specific point in time (synchronic), and the necessary and sufficient conditions of personal identity (PI) over time (diachronic) are traditionally separated. Hence, the transition between both timescales of a person's life remains largely unclear. Personal habits reflect a decision-making (DM) process ...
Wang Hao H 0000-0002-1187-0824 Key Laboratory of C&PC Structures of Ministry of Education, Southeast University, No. 2 Sipailou, Nanjing 210096, - - 2014
The structural health monitoring system (SHMS) provides an effective tool to conduct full-scale measurements on existing bridges for essential research on bridge wind engineering. In July 2008, Typhoon Fung-Wong lashed China and hit Sutong cable-stayed bridge (SCB) in China. During typhoon period, full-scale measurements were conducted to record the wind ...
Asgari B B Department of Civil & Structural Engineering, Faculty of Engineering & Built Environment, Universiti Kebangsaan Malaysia (UKM), 43600 Bangi, Selangor, - - 2014
Cable-stayed bridges are one of the most popular types of long-span bridges. The structural behaviour of cable-stayed bridges is sensitive to the load distribution between the girder, pylons, and cables. The determination of pretensioning cable stresses is critical in the cable-stayed bridge design procedure. By finding the optimum stresses in ...
Zeng Xiang-Tian XT Institute of Tourism, Sanming University, Sanming, Fujian 365004, - - 2014
The aim of this paper is to develop a method for ranking trapezoidal intuitionistic fuzzy numbers (TrIFNs) in the process of decision making in the intuitionistic fuzzy environment. Firstly, the concept of TrIFNs is introduced. Arithmetic operations and cut sets over TrIFNs are investigated. Then, the values and ambiguities of ...
Arbisi Paul A PA a Minneapolis VA Health Care System , Minneapolis , - - 2013
In this Special Section, 7 studies focusing on the PSY-5 model of individual differences relevant to adaptive functioning are presented. The first study by Harkness, McNulty, et al. (this issue) describes the development of the revised PSY-5 scales for the MMPI-2-RF, followed by another article by Harkness, Reynolds, and Lilienfeld (this ...
Yun Hae-Bum HB Department of Civil, Environmental and Construction Engineering, University of Central Florida, Orlando, FL 32816, - - 2013
This paper presents the bridge cable inspection robot developed in Korea. Two types of the cable inspection robots were developed for cable-suspension bridges and cable-stayed bridge. The design of the robot system and performance of the NDT techniques associated with the cable inspection robot are discussed. A review on recent ...
Scognamiglio J - - 2013
A toxicologic and dermatologic review of 2-cyclohexyl-1,6-heptadien-3-one when used as a fragrance ingredient is presented. 2-Cyclohexyl-1,6-heptadien-3-one is a member of the fragrance structural group Alkyl Cyclic Ketones. These fragrances can be described as being composed of an alkyl, R1, and various substituted and bicyclic saturated or unsaturated cyclic hydrocarbons, R2, ...
Wang Li - - 2013
A slackening to zero tension by large length release (~20 %) and a restretch of active muscle fibres cause a fall and a redevelopment in tension. According to the model of Brenner (Proc Natl Acad Sci USA 85(9):3265-3269, 1988), the rate constant of tension redevelopment (k TR) is the sum of ...
Alschuler Daniel M - - 2013
EEG topographies may be distorted by electrode bridges, typically caused by electrolyte spreading between adjacent electrodes. We therefore sought to determine the prevalence of electrode bridging and its potential impact on the EEG literature. Five publicly-available EEG datasets were evaluated for evidence of bridging using a new screening method that ...
Carmody Jennifer J - - 2013
Billings Clinic learned the following important lessons in implementing a pharmacy revenue integrity initiative: Integrate pharmacy data as fully as possible. Audit and review pharmacy data regularly to validate the data and identify key areas where education can be provided to support accuracy and compliance. Use technology to bridge gaps ...
Lello Joanne - - 2013
A transmission model clarifies the effects of influenza on pneumococcal pneumonia and bridges the gap between individual animal experiments and human epidemiological data (Shrestha et al., this issue).
Wang Zhen - - 2013
Robust aerogels derived from a thiol-ene clicked bridged silsesquioxane precursor are obtained by a facile vacuum-drying method. With rather low densities, the flexible aerogels are still robust enough to bear at least 20 times repeating compressions and further functionalization by wet doping. The durability and facile preparation procedure promise the ...
Potter Kristen A - - 2013
Despite decades of work on climate change biology, the scientific community remains uncertain about where and when most species distributions will respond to altered climates. A major barrier is the spatial mismatch between the size of organisms and the scale at which climate data are collected and modeled. Using a ...
Cagan Ross L - - 2013
To better translate basic research findings into the clinic, we are moving away from the traditional one-gene-one-phenotype model towards the discovery of complex mechanisms. In this Editorial, the new Editor-in-Chief and Senior Editors of Disease Models & Mechanisms (DMM) discuss the role that the journal will play in this transition. ...
Schellekens Elisabeth - - 2013
In the context of a broad welcome to Bullot & Reber's (B&R's) proposals concerning the incorporation of contextual awareness into the study of the psychology of art appreciation, I raise two concerns. First, the proposal makes no allowance for degrees of relevance of contextual awareness to appreciation. Second, the authors ...
Lux Andrew L - - 2013
Infantile spasms remain a challenging condition to study and treat, and although they form the commonest epilepsy syndrome with onset in infancy, the challenge is broadened by the wide range of potential underlying causes. The field of study remains dynamic, with debates relating to case definitions and organising structures for ...
Garnier Simon - - 2013
Robustness and adaptability are central to the functioning of biological systems, from gene networks to animal societies. Yet the mechanisms by which living organisms achieve both stability to perturbations and sensitivity to input are poorly understood. Here, we present an integrated study of a living architecture in which army ants ...
Fraser James S JS Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA 94158, USA. - - 2013
There is a wide gap between the generation of large-scale biological data sets and more-detailed, structural and mechanistic studies. However, recent studies that explicitly combine data from systems and structural biological approaches are having a profound effect on our ability to predict how mutations and small molecules affect atomic-level mechanisms, ...
Galanopoulou Aristea S - - 2013
Infantile spasms are age-specific seizures of infantile epileptic encephalopathies that are usually associated with poor epilepsy and neurodevelopmental outcomes. The current treatments are not always effective and may be associated with significant side effects. Various mechanisms have been proposed as pathogenic for infantile spasms, including cortical or brainstem dysfunction, disruption ...
Lan Yueheng - - 2013
Transitions between different condensed phases, molecular conformations, chemical compositions, or spatiotemporal patterns play important roles in many branches of natural science and at the same time incur serious challenges in their precise characterization. We design an approach for computing connecting orbits bridging steady states based on the renormalization group analysis. ...
Spjuth Ola - - 2013
The InChI algorithms are written in C++ and not available as Java library. Integration into software written in Java therefore requires a bridge between C and Java libraries, provided by the Java Native Interface (JNI) technology. We here describe how the InChI library is used in the Bioclipse workbench and ...
Talluri Rajesh - - 2013
Rare variants have increasingly been cited as major contributors in the disease etiology of several complex disorders. Recently, several approaches have been proposed for analyzing the association of rare variants with disease. These approaches include collapsing rare variants, summing rare variant test statistics within a particular locus to improve power, ...
Evinger Craig - - 2013
The focal dystonia benign essential blepharospasm (BEB) affects as many as 40,000 individuals in the United States. This dystonia is characterized by trigeminal hyperexcitability, photophobia, and most disabling of the symptoms, involuntary spasms of lid closure that can produce functional blindness. Like many focal dystonias, BEB appears to develop from ...
Liu Wenjia - - 2013
This paper investigates the time series representation methods and similarity measures for sensor data feature extraction and structural damage pattern recognition. Both model-based time series representation and dimensionality reduction methods are studied to compare the effectiveness of feature extraction for damage pattern recognition. The evaluation of feature extraction methods is ...
Jiao Yubo - - 2013
Performance evaluation of a bridge is critical for determining the optimal maintenance strategy. An unsupervised bridge superstructure state assessment method is proposed in this paper based on fuzzy clustering and bridge field measured data. Firstly, the evaluation index system of bridge is constructed. Secondly, a certain number of bridge health ...
Swenson Kristine - - 2013
Silas Weir Mitchell's novel, When All the Woods are Green (1894), acknowledges the medical use of mindblindness (agnosia) but also casts it as a developmental disorder, bringing it provocatively close to how current neuropsychologist, Simon Baron-Cohen and his followers use the term in relation to autism. This chapter traces the ...
Gong Kai K Web Sciences Center, University of Electronic Science and Technology of China, Chengdu, People's Republic of China ; Department of Physics, The Chinese University of Hong Kong, Shatin, Hong Kong, People's Republic of - - 2013
An efficient algorithm that can properly identify the targets to immunize or quarantine for preventing an epidemic in a population without knowing the global structural information is of obvious importance. Typically, a population is characterized by its community structure and the heterogeneity in the weak ties among nodes bridging over ...
Armagan Artin A SAS Institute Inc., Durham, NC 27513, USA, - - 2013
We propose a generalized double Pareto prior for Bayesian shrinkage estimation and inferences in linear models. The prior can be obtained via a scale mixture of Laplace or normal distributions, forming a bridge between the Laplace and Normal-Jeffreys' priors. While it has a spike at zero like the Laplace density, ...
van der Hout Sanne - - 2013
The emerging field of ecological genomics promises to bring about a marriage between ecological and laboratory-based, genomic investigations. In this paper, I will reflect on this promise by exploring how ecology and genomics are integrated in the two approaches that currently dominate this field: the organism-centred approach, focusing on individual ...
Yan Su S IBM Almaden Research Lab, San Jose, CA, - - 2013
Identifying drug-drug interactions is an important and challenging problem in computational biology and healthcare research. There are accurate, structured but limited domain knowledge and noisy, unstructured but abundant textual information available for building predictive models. The difficulty lies in mining the true patterns embedded in text data and developing efficient ...
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