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Walenga Ross L RL Department of Mechanical and Nuclear Engineering, Virginia Commonwealth University, Richmond, - - 2014
Nasal delivery of lung targeted pharmaceutical aerosols is ideal for drugs that need to be administered during high flow nasal cannula (HFNC) gas delivery, but based on previous studies losses and variability through both the delivery system and nasal cavity are expected to be high. The objective of this study ...
Bevilacqua Alessandro A Department of Computer Science and Engineering (DISI), University of Bologna, Viale Risorgimento 2, 40136 Bologna, Italy; Advanced Research Center on Electronic Systems for Information and Communication Technologies "Ercole De Castro" (ARCES), University of Bologna, Via Toffano 2/2, 40125, Bologna, Italy. Electronic address: - - 2014
To study the effects of four different rigid alignment approaches on both time-concentration curves (TCCs) and perfusion maps in computed tomography perfusion (CTp) studies of liver and lung tumors. Eleven data sets in patients who were subjected to axial CTp after contrast agent administration were assessed. Each data set consists ...
Kadlecek Stephen S Department of Radiology, University of Pennsylvania, Philadelphia, PA, - - 2014
Although relatively metabolically inactive, the lung has an important role in maintaining systemic glycolytic intermediate and cytosolic redox balance. Failure to perform this function appropriately may lead to lung disease progression, including systemic aspects of these disorders. In this study, we experimentally probe the response of the isolated, perfused organ ...
Goossens Lucas M - - 2014
The 2013 GOLD classification system for COPD distinguishes four stages: A (low symptoms, low exacerbation risk), B (high symptoms, low risk), C (low symptoms, high risk) and D (high symptoms, high risk). Assessment of risk is based on exacerbation history and airflow obstruction, whatever results in a higher risk grouping. ...
O'Reilly Megan M University of - - 2014
Bronchopulmonary dysplasia (BPD) is the chronic lung disease of prematurity that affects very preterm infants. Although advances in perinatal care have enabled the survival of infants born as early as 23-24 weeks of gestation, the challenge of promoting lung growth while protecting the ever more immature lung from injury is ...
Wnuk P P Oncology Centre - Prof. Lukaszczyk Memorial Hospital in Bydgoszcz, Department of Thoracic Surgery and Tumours, Bydgoszcz, Poland - - - 2014
Mediastinal lymph nodes staging in NSCLC (non small cell lung cancer) is of undisputable importance. Although relatively precise, diagnostic modalities, mediastinoscopy and EBUS/EUS - TBNA (endobronchial/endoscopic ultrasound guided--transbronchial needle aspiration) still employ certain level of invasiveness. Artificial Neural Network (ANN) is an established predictor tool which, due to underlying distribution ...
Yoder Bradley A BA University of Utah - - 2014
Much of the progress in improved neonatal care, particularly management of under-developed preterm lungs, has been aided by investigations of multiple animal models, including the neonatal baboon (Papio species). In this chapter we highlight how the preterm baboon model at both140d and 125 d gestation (term equivalent 185d) has advanced ...
Gill Gurman G Department of Electrical and Computer Engineering, The University of Iowa, Iowa City, Iowa 52242 and The Iowa Institute for Biomedical Imaging, The University of Iowa, Iowa City, Iowa - - 2014
The automated correct segmentation of left and right lungs is a nontrivial problem, because the tissue layer between both lungs can be quite thin. In the case of lung segmentation with left and right lung models, overlapping segmentations can occur. In this paper, the authors address this issue and propose ...
Wang Fengfeng F Department of Health Technology and Informatics, Hong Kong Polytechnic University, Hong Kong, - - 2014
EGFR signaling pathway and microRNAs (miRNAs) are two important factors for development and treatment in non-small cell lung cancer (NSCLC). Microarray analysis enables the genome-wide expression profiling. However, the information from microarray data may not be fully deciphered through the existing approaches. In this study we present an mRNA:miRNA stepwise ...
Valeri Linda L Department of Biostatistics and Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA, 02115, - - 2014
Mediation analysis is a popular approach to examine the extent to which the effect of an exposure on an outcome is through an intermediate variable (mediator) and the extent to which the effect is direct. When the mediator is mis-measured, the validity of mediation analysis can be severely undermined. In ...
Dharmakumara Mahesh M The Alfred Hospital - - 2014
Inert gas washout measurements using oxygen, in the lungs of small animals are complicated by the continuous process of oxygen consumption (VO2). The Multiple Breath Nitrogen Washout (MBNW) technique uses the alveolar slope to determine measures of ventilation inhomogeneity in the acinar (Sacin) and conducting (Scond) airway regions, as well ...
Shao Yeqin - - 2014
Lung field segmentation in the posterior-anterior (PA) chest radiograph is important for pulmonary disease diagnosis and hemodialysis treatment. Due to high shape variation and boundary ambiguity, accurate lung field segmentation from chest radiograph is still a challenging task. To tackle these challenges, we propose a joint shape and appearance sparse ...
Deppen Stephen A SA *Department of Surgery, Tennessee Valley Healthcare System, Veterans Affairs, Nashville, Tennessee; ††Department of Thoracic Surgery, §Department of Medicine, Division of Pulmonary and Critical Care Medicine, ¶Vanderbilt-Ingram Cancer Center, and **School of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee; †Department of Biostatistics, Vanderbilt University, Nashville, Tennessee; and ‡Department of Critical Care Medicine, ‖Department of Radiology, and #Geriatric Research Education Clinical - - 2014
Existing predictive models for lung cancer focus on improving screening or referral for biopsy in general medical populations. A predictive model calibrated for use during preoperative evaluation of suspicious lung lesions is needed to reduce unnecessary operations for a benign disease. A clinical prediction model (Thoracic Research Evaluation And Treatment ...
Falzarano Darryl D Disease Modeling and Transmission, Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, Montana, United States of - - 2014
The availability of a robust disease model is essential for the development of countermeasures for Middle East respiratory syndrome coronavirus (MERS-CoV). While a rhesus macaque model of MERS-CoV has been established, the lack of uniform, severe disease in this model complicates the analysis of countermeasure studies. Modeling of the interaction ...
Gupta R P RP Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College, London, - - 2014
The use of different spirometric definitions for chronic obstructive pulmonary disease (COPD) has made an informative review of the available prevalence surveys impossible. To derive adjustment factors that allow the comparison of studies using different spirometric criteria. Pre- and post-bronchodilator one-second forced expiratory volume (FEV1) and forced vital capacity (FVC) ...
Montrikittiphant Thanit T Department of Chemistry, Imperial College London, South Kensington Campus, SW7 2AZ, London, UK; Polymer and Composite Engineering (PaCE) group, Department of Chemical Engineering, Imperial College London, South Kensington Campus, SW7 2AZ, London, - - 2014
Bacterial cellulose (BC) is often regarded as a prime candidate nano-reinforcement for the production of renewable nanocomposites. However, the mechanical performance of most BC nanocomposites is often inferior compared with commercially available polylactide (PLLA). Here, the manufacturing concept of paper-based laminates is used, i.e., "PaPreg," to produce BC nanopaper reinforced ...
Lum Kirsten J KJ Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, DHHS, Rockville, MD 20852, USA and Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, - - 2014
Prospective pregnancy studies are a valuable source of longitudinal data on menstrual cycle length. However, care is needed when making inferences of such renewal processes. For example, accounting for the sampling plan is necessary for unbiased estimation of the menstrual cycle length distribution for the study population. If couples can ...
Pond Gregory J GJ Environmental Assessment and Innovation Division, Office of Monitoring and Assessment Region III, U.S. Environmental Protection Agency, 1060 Chapline St., Wheeling, WV, 26003, USA, - - 2014
Recent studies have documented adverse effects to biological communities downstream of mountaintop coal mining and valley fills (VF), but few data exist on the longevity of these impacts. We sampled 15 headwater streams with VFs reclaimed 11-33 years prior to 2011 and sampled seven local reference sites that had no VFs. ...
Shon Kilhwan K Department of Ophthalmology, College of Medicine, University of Ulsan, Asan Medical Center , Seoul , Korea - - 2014
Abstract Purpose: To evaluate whether pointwise regression analysis of serial measures of retinal sensitivity can predict future visual field (VF) loss. Methods: Medical records of 158 patients with glaucomatous eyes with at least 6 years follow-up and 10 reliable VF exams were retrospectively analyzed. The entire follow-up period was divided ...
Bhattacharya Pinaki P School of Mechanical Engineering, Purdue University, West Lafayette, IN 47907 - - 2014
Computational models of vocal fold (VF) vibration are becoming increasingly sophisticated, their utility currently transiting from exploratory research to predictive research. However, validation of such models has remained largely qualitative, raising questions over their applicability to interpret clinical situations. In this paper, a computational model with a segregated implementation is ...
Deng Lisha L Devers Eye, Legacy Research Institute, 1225 NE 2nd Ave, portland, OR, 97232, United - - 2014
Purpose: To reduce variability and improve measurements of true change signal in visual field (VF) assessments through the use of filters that combine both functional and structural test results. Methods: Humphrey VF data (SITA Std, 24-2) and confocal scanning laser ophthalmoscopy (HRT) data from 1057 eyes of 637 participants were ...
Boggia Antonio A University of Perugia, Borgo XX Giugno, 74, 06121 Perugia, Italy. Electronic address: - - 2014
Rural Development is a priority in Europe and it is supported by specific, financial programmes. At the same time, sustainability is the key word for the European Union to construct programmes and policies for all human activities. However, measuring sustainability of rural areas is not easy, due to their particular ...
Mohiuddin Syed - - 2014
The surgical insertion of Ventilation Tubes (VTs) for the management of persistent bilateral Otitis Media with Effusion (OME) in children remains a contentious issue due to the varying opinions regarding the risks and benefits of this procedure. The aim of this study was to evaluate the economic impact of VTs ...
Hoekstra Arjen Y AY Twente Water Centre, Institute for Innovation and Governance Studies, University of Twente, Enschede, Netherlands. - - 2014
Within the context of Earth's limited natural resources and assimilation capacity, the current environmental footprint of humankind is not sustainable. Assessing land, water, energy, material, and other footprints along supply chains is paramount in understanding the sustainability, efficiency, and equity of resource use from the perspective of producers, consumers, and ...
Naganawa Mika M PET Center, Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, CT, USA. Electronic address: - - 2014
Kappa opioid receptors (KOR) are implicated in several brain disorders. In this report, a first-in-human Positron Emission Tomography (PET) study was conducted with the potent and selective KOR agonist tracer, [(11)C]GR103545, to determine an appropriate kinetic model for analysis of PET imaging data and assess the test-retest reproducibility of model-derived ...
Fenichel Eli P EP Yale University, New Haven, CT, USA, - - 2014
Developing a quantitative science of sustainability requires bridging mathematical concepts from fields contributing to sustainability science. The concept of substitutability is central to sustainability but is defined differently by different fields. Specifically, economics tends to define substitutability as a marginal concept while fields such as ecology tend to focus on ...
Sturm Robert R Brunnleitenweg 41, A-5061 Elsbethen, Salzburg, - - 2014
In the past decades, aerosol bolus inhalation increasingly came into the focus of medical interest due to its potential as a non-invasive technique for the diagnosis of lung diseases. The experimental studies were accompanied by the development of theoretical contributions dealing with aerosol bolus behaviour in healthy and diseased lungs. ...
Bhattacharya Pinaki P School of Mechanical Engineering, Purdue University, West Lafayette, IN 47907, - - 2014
Predicting phonation conditions that are benign to voice health remains a biomechanically relevant problem. Our objective is to provide insight into vocal fold (VF) hydration based on continuum-based VF models that are able to compute VF stresses during phonation and a scheme for the extraction and generalization of such computational ...
Xue Qian Q Department of Mechanical Engineering, University of Maine, Orono, - - 2014
The present study explores the use of a continuum-based computational model to investigate the effect of left-right tension imbalance on vocal fold (VF) vibrations and glottal aerodynamics, as well as its implication on phonation. The study allows us to gain new insights into the underlying physical mechanism of irregularities induced ...
Pritchard Duncan D Aran Hall School; Bangor - - 2014
Behavioral Momentum Theory (BMT) has inspired animal models of treatment relapse. We translated the models of reinstatement and resurgence into clinical procedures to test whether relapse tests would replicate behavior pattern found in basic research. Following multiple schedule baseline reinforcement of a 16-year-old male's problem behavior at equal rates by ...
Owen David R DR Division of Brain Sciences, Department of Medicine, Imperial College, London, - - 2014
Positron emission tomography (PET) targeting the 18 kDa translocator protein (TSPO) is used to quantify neuroinflammation. Translocator protein is expressed throughout the brain, and therefore a classical reference region approach cannot be used to estimate binding potential (BPND). Here, we used blockade of the TSPO radioligand [(11)C]PBR28 with the TSPO ligand ...
Broggio D D *Institut de Radioprotection et de Sûreté Nucléaire, IRSN/PRP-HOM/SDI/LEDI 92262 Fontenay-aux-Roses Cedex, France; †AREVA NC, Etablissement de la Hague, Laboratoire de Biologie Médicale, 50444 Beaumont-Hague Cedex, France; ‡Service d'Imagerie Pédiatrique, CHU Bicêtre, AP-HP, Paris, - - 2014
The thickness and fat fraction of the chest wall are important parameters for in vivo lung monitoring. They have been measured from ultrasonic images on 374 male workers of the French nuclear industry using four measurement locations, as dictated by the size and position of the germanium detectors used for ...
Castilla Ana E AE a Assistant Professor, Department of Orthodontics, Oregon Health & Science University, Portland, - - 2014
Abstract Objective: To measure and compare bracket transfer accuracy of five indirect bonding (IDB) techniques. Materials and Methods: Five IDB techniques were studied: double polyvinyl siloxane (double-PVS), double vacuum-form (double-VF), polyvinyl siloxane vacuum-form (PVS-VF), polyvinyl siloxane putty (PVS-putty), and single vacuum-form (single-VF). Brackets were bonded on 25 identical stone working ...
Rusjan Pablo M PM Research Imaging Centre, Centre for Addiction and Mental Health (CAMH), Toronto, Ontario, - - 2014
This article describes the kinetic modeling of [(11)C]SL25.1188 ([(S)-5-methoxymethyl-3-[6-(4,4,4-trifluorobutoxy)-benzo[d]isoxazol-3-yl]-oxazolidin-2-[(11)C]one]) binding to monoamine oxidase B (MAO-B) in the human brain using high-resolution positron emission tomography (PET). Seven healthy subjects underwent two separate 90- minute PET scans after an intravenous injection of [(11)C]SL25.1188. Complementary arterial blood sampling was acquired. Radioactivity was quickly eliminated ...
Radaelli Giovanni G Politecnico di - - 2014
Objectives: This study describes the health technology assessment (HTA) framework introduced by Regione Lombardia to regulate the introduction of new technologies. The study outlines the process and dimensions adopted to prioritize, assess and appraise the requests of new technologies. Methods: The HTA framework incorporates and adapts elements from the EUnetHTA ...
Elshrif Mohamed M MM B. Thomas Golisano College of Computing and Information Sciences, Rochester Institute of Technology, Rochester, New York, United States of - - 2014
Numerical integration of mathematical models of heart cell electrophysiology provides an important computational tool for studying cardiac arrhythmias, but the abundance of available models complicates selecting an appropriate model. We study the behavior of two recently published models of human ventricular action potentials, the Grandi-Pasqualini-Bers (GPB) and the O'Hara-Virág-Varró-Rudy (OVVR) ...
Castanheira Guilherme G 0000-0001-9488-3411 Laboratory of Building Physics and Construction Technology, Department of Civil Engineering, School of Engineering, University of Minho, 4800-058 Guimarães, - - 2014
This paper analyses the current trends in sustainability assessment. After about 15 years from the launch of sustainability assessment tools, focused on buildings evaluation, the paradigm of sustainability assessment tools is changing from the building scale to the built environment scale. Currently European cities and cities around the world are ...
Xue Ming M Institute of Image Communication and Network Engineering, Shanghai Jiao Tong University, Shanghai 200240, China. - - 2014
To tackle robust object tracking for video sensor-based applications, an online discriminative algorithm based on incremental discriminative structured dictionary learning (IDSDL-VT) is presented. In our framework, a discriminative dictionary combining both positive, negative and trivial patches is designed to sparsely represent the overlapped target patches. Then, a local update (LU) ...
Subramanian Sowmya S Department of Electrical & Computer Engineering, University of Maryland, College Park, Maryland, United States of - - 2014
Loop mediated isothermal amplification (LAMP) is a highly efficient, selective and rapid DNA amplification technique for genetic screening of pathogens. However, despite its popularity, there is yet no mathematical model to quantify the outcome and no well-defined metric for comparing results that are available. LAMP is intrinsically complex and involves ...
Shiba Daisuke D Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan; Keisho-kai Iidabashi Eye Clinic, Tokyo, - - 2014
To design a mathematical model that can predict the relationship between the ganglion cell complex (GCC) thickness and visual field sensitivity (VFS) in glaucoma patients. Retrospective cross-sectional case series. Within 3 months from VFS measurements by the Humphrey field analyzer 10-2 program, 83 eyes underwent macular GCC thickness measurements by ...
Baradaran Samaneh S Dept. of Medical Radiation Engineering, Amirkabir University of Technology, Tehran, Iran ; National Radaition Protection Department, Iranian Nuclear Regulatory Authority, Tehran, - - 2014
Alpha particle irradiation from radon progeny is one of the major natural sources of effective dose in the public population. Oncogenic transformation is a biological effectiveness of radon progeny alpha particle hits. The biological effects which has caused by exposure to radon, were the main result of a complex series ...
Ma Shuyi S Institute for Systems Biology, Seattle, Washington, United States of America; Department of Chemical and Biomolecular Engineering, University of Illinois, Urbana, Illinois, United States of - - 2014
The biomarker discovery field is replete with molecular signatures that have not translated into the clinic despite ostensibly promising performance in predicting disease phenotypes. One widely cited reason is lack of classification consistency, largely due to failure to maintain performance from study to study. This failure is widely attributed to ...
Colin Thierry - - 2014
Metastases to the lung are a therapeutic challenge because some are fast-evolving while others evolve slowly. Any insight that can be provided for which nodule has to be treated first would help clinicians. In this work, we evaluate the aggressiveness but also the response to treatment of these nodules using ...
Bárdossy András A University of Stuttgart, Institut für Wasser- und Umweltsystemmodellierung, Pfaffenwaldring 61, 70569 Stuttgart, - - 2013
The paper presents a diagnostic algorithm for classifying cardiac tachyarrhythmias for implantable cardioverter defibrillators (ICDs). The main aim was to develop an algorithm that could reduce the rate of occurrence of inappropriate therapies, which are often observed in existing ICDs. To achieve low energy consumption, which is a critical factor ...
Buys L L School of Design, Queensland University of Technology, 2 George Street, Brisbane, Queensland 4000, Australia. Electronic address: - - 2013
Sustainability is a key driver for decisions in the management and future development of industries. The World Commission on Environment and Development (WCED, 1987) outlined imperatives which need to be met for environmental, economic and social sustainability. Development of strategies for measuring and improving sustainability in and across these domains, ...
Sogo Ana - - 2013
So far, the accuracy of tidal volume(VT) and leak measures provided by the built-in software of commercial home ventilators has only been tested using bench linear models with fixed calibrated and continuous leaks. The objective was to assess the reliability of the estimation of tidal volume (VT) and unintentional leaks ...
Pareto Deborah - - 2013
AbstractThe aim of this work was to quantify the brain distribution of the enzyme aromatase in the female baboon with positron emission tomography and the tracer [11C]vorozole using three different quantification methods for estimating the total distribution volume (VT): a graphical method, compartment modeling, and a tissue to plasma ratio. ...
Alonso-Atienza Felipe - - 2013
Early detection of ventricular fibrillation (VF) and rapid ventricular tachycardia (VT) is crucial for the success of the defibrillation therapy. A wide variety of detection algorithms have been proposed based on temporal, spectral, or complexity parameters extracted from the ECG. However, these algorithms are mostly constructed by considering each parameter ...
Lohith Talakad G - - 2013
[(11)C]NOP-1A is a novel high-affinity PET ligand for imaging nociceptin/orphanin FQ peptide (NOP) receptors. Here, we report reproducibility and reliability measures of binding parameter estimates for [(11)C]NOP-1A binding in brain of healthy humans After intravenous injection of [(11)C]NOP-1A PET scans were conducted twice on eleven healthy volunteers on the same ...
Szelényi Zsuzsanna - - 2013
The diagnostic values of the aVR lead or "Vereckei algorithm," and the lead II R-wave peak time (RWPT) criterion, recently devised for the differential diagnosis of wide QRS complex tachycardias (WCTs), were compared. A total of 212 WCTs (142 ventricular tachycardias [VTs], 62 supraventricular tachycardias [SVT], and eight preexcitation SVTs) ...
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