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Zhan Xiang X Department of Statistics, Pennsylvania State University, University Park, PA 16802, - - 2015
With evolving genomic technologies, it is possible to get different measures of the same underlying biological phenomenon using different technologies. The goal of this paper is to build a prediction model for an outcome variable Y from covariates X. Besides X, we have surrogate covariates W which are related to ...
Gibaldi Agostino A Advanced Research Center on Electronic Systems for Information and Communication Technologies "Ercole De Castro" (ARCES), University of Bologna, Via Toffano 2/2, Bologna 40125, - - 2015
Tissue perfusion is commonly used to evaluate lung tumor lesions through dynamic contrast-enhanced computed tomography (DCE-CT). The aim of this study was to improve the reliability of the blood flow (BF) maps by means of a guided sampling of the tissue time-concentration curves (TCCs). Fourteen selected CT perfusion (CTp) examinations ...
Nadar M Y MY Internal Dosimetry Section, Radiation Safety Systems Division, Bhabha Atomic Research Centre, Mumbai 400085, India - - 2014
Assessment of intake due to long-lived actinides by inhalation pathway is carried out by lung monitoring of the radiation workers inside totally shielded steel room using sensitive detection systems such as Phoswich and an array of HPGe detectors. In this paper, uncertainties in the lung activity estimation due to positional ...
Walenga Ross L RL Department of Mechanical and Nuclear Engineering, Virginia Commonwealth University, Richmond, - - 2014
Nasal delivery of lung targeted pharmaceutical aerosols is ideal for drugs that need to be administered during high flow nasal cannula (HFNC) gas delivery, but based on previous studies losses and variability through both the delivery system and nasal cavity are expected to be high. The objective of this study ...
Tashkin Donald P DP Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California, - - 2014
Extent of systemic sclerosis (SSc)-related interstitial lung disease (ILD) assessed from thoracic high-resolution CT (HRCT) predicts disease course, mortality and treatment response. While quantitative HRCT analyses of extent of lung fibrosis (QLFib) or total interstitial lung disease (QILD) are more sensitive and reproducible than visual HRCT assessments of SSc-ILD, these ...
Steininger Robert J RJ 3rd Green Center for Systems Biology, University of Texas Southwestern Medical Center, Dallas, - - 2014
Microscopy reveals complex patterns of cellular heterogeneity that can be biologically informative. However, a limitation of microscopy is that only a small number of biomarkers can typically be monitored simultaneously. Thus, a natural question is whether additional biomarkers provide a deeper characterization of the distribution of cellular states in a ...
Michael Claire W CW Department of Pathology, Case Western Reserve University, University Hospitals Case Medical Center, Cleveland, Ohio, - - 2014
Objective: First introduced for the processing of cervico-vaginal samples, liquid-based cytology (LBC) soon found application in nongynecological specimens, including bronchoscopic brushings, washings and transcutaneous and transbronchial aspiration biopsy of the lung as well as pleural effusions. This article reviews the existing literature related to these specimens along with the authors' ...
Fogliata Antonella A Oncology Institute of Southern Switzerland, Bellinzona, Switzerland. Electronic address: - - 2014
To evaluate the performance of a model-based optimisation process for volumetric modulated arc therapy applied to advanced lung cancer and to low risk prostate carcinoma patients. Two sets each of 27 previously treated patients, were selected to train models for the prediction of dose-volume constraints. The models were validated on ...
Khan Iftekhar - - 2014
BackgroundThe performance of the Beta Binomial (BB) model is compared with several existing models for mapping the EORTC QLQ-C30 (QLQ-C30) on to the EQ-5D-3L using data from lung cancer trials.MethodsData from 2 separate non small cell lung cancer clinical trials (TOPICAL and SOCCAR) are used to develop and validate the ...
Grannis Frederic W FW - - 2014
The completion of the National Lung Screening Trial (NLST), a randomized controlled trial (RCT) of lung cancer screening (LCS), in 2010 provided powerful RCT evidence of the efficacy and safety of computed tomography-based screening; nevertheless, the study had important limitations. Failure to understand these limitations has had substantial adverse effects. ...
Limjunyawong Nathachit N Department of Environmental Health Sciences, Johns Hopkins University Bloomberg School of Public Heath, 615 North Wolfe Street, Baltimore, MD, - - 2014
In the official joint policy document of the American Thoracic Society and European Respiratory Society (Hsia et al., 2010), the need for proper stereologic assessment of lungs was emphasized. In this document it was emphasized that for the quantitative analysis of lung histologic sections, one of the most robust and ...
Bevilacqua Alessandro A Department of Computer Science and Engineering (DISI), University of Bologna, Viale Risorgimento 2, 40136 Bologna, Italy; Advanced Research Center on Electronic Systems for Information and Communication Technologies "Ercole De Castro" (ARCES), University of Bologna, Via Toffano 2/2, 40125, Bologna, Italy. Electronic address: - - 2014
To study the effects of four different rigid alignment approaches on both time-concentration curves (TCCs) and perfusion maps in computed tomography perfusion (CTp) studies of liver and lung tumors. Eleven data sets in patients who were subjected to axial CTp after contrast agent administration were assessed. Each data set consists ...
Gibbons Melissa M - - 2014
A detailed three-dimensional finite element model (FEM) of the sheep thorax was developed to predict heterogeneous and volumetric lung injury due to blast. A shared node mesh of the sheep thorax was constructed from a computed tomography (CT) scan of a sheep cadaver, and while most material properties were taken ...
Avanzo M M Medical Physics, CRO Aviano National Cancer Institute, 33081 Aviano, Italy. Electronic address: - - 2014
To derive Normal Tissue Complication Probability (NTCP) models for severe patterns of early radiological radiation-induced lung injury (RRLI) in patients treated with radiotherapy (RT) for lung tumors. Second, derive threshold doses and optimal doses for prediction of RRLI to be used in differential diagnosis of tumor recurrence from RRLI during ...
Hidaka Nobuhiro N Dpartment of Maternal Fetal Medicine, Osaka Medical Center and Research Institute for Maternal and Child Health, Izumi, - - 2014
Observed/expected lung area to head circumference ratio (o/e LHR) and lung to thorax transverse area ratio (LTR) are the sonographic indicators of postnatal outcome in fetuses with congenital diaphragmatic hernia (CDH), and they are not influenced by gestational age. We aimed to evaluate the relationship between these 2 parameters in ...
Nihei Mayumi M Department of Respiratory Medicine, Tohoku University Hospital, - - 2014
Chronic inflammation induces lymphangiogenesis and blood vessel remodeling. Since aged pneumonia patients often have repeated episodes of aspiration pneumonia, the pathogenesis may involve chronic inflammation. For lymphangiogenesis, VEGFR-3 and its ligand VEGF-C are key factors. No previous studies have examined chronic inflammation or vascular changes in aspiration pneumonia or its ...
Hao Wenrui W Mathematical Biosciences Institute, The Ohio State University, Columbus, - - 2014
Sarcoidosis is a disease involving abnormal collection of inflammatory cells forming nodules, called granulomas. Such granulomas occur in the lung and the mediastinal lymph nodes, in the heart, and in other vital and nonvital organs. The origin of the disease is unknown, and there are only limited clinical data on ...
Kadlecek Stephen S Department of Radiology, University of Pennsylvania, Philadelphia, PA, - - 2014
Although relatively metabolically inactive, the lung has an important role in maintaining systemic glycolytic intermediate and cytosolic redox balance. Failure to perform this function appropriately may lead to lung disease progression, including systemic aspects of these disorders. In this study, we experimentally probe the response of the isolated, perfused organ ...
Goossens Lucas M - - 2014
The 2013 GOLD classification system for COPD distinguishes four stages: A (low symptoms, low exacerbation risk), B (high symptoms, low risk), C (low symptoms, high risk) and D (high symptoms, high risk). Assessment of risk is based on exacerbation history and airflow obstruction, whatever results in a higher risk grouping. ...
O'Reilly Megan M University of - - 2014
Bronchopulmonary dysplasia (BPD) is the chronic lung disease of prematurity that affects very preterm infants. Although advances in perinatal care have enabled the survival of infants born as early as 23-24 weeks of gestation, the challenge of promoting lung growth while protecting the ever more immature lung from injury is ...
Wnuk P P Oncology Centre - Prof. Lukaszczyk Memorial Hospital in Bydgoszcz, Department of Thoracic Surgery and Tumours, Bydgoszcz, Poland - - - 2014
Mediastinal lymph nodes staging in NSCLC (non small cell lung cancer) is of undisputable importance. Although relatively precise, diagnostic modalities, mediastinoscopy and EBUS/EUS - TBNA (endobronchial/endoscopic ultrasound guided--transbronchial needle aspiration) still employ certain level of invasiveness. Artificial Neural Network (ANN) is an established predictor tool which, due to underlying distribution ...
Yoder Bradley A BA University of Utah - - 2014
Much of the progress in improved neonatal care, particularly management of under-developed preterm lungs, has been aided by investigations of multiple animal models, including the neonatal baboon (Papio species). In this chapter we highlight how the preterm baboon model at both140d and 125 d gestation (term equivalent 185d) has advanced ...
Gill Gurman G Department of Electrical and Computer Engineering, The University of Iowa, Iowa City, Iowa 52242 and The Iowa Institute for Biomedical Imaging, The University of Iowa, Iowa City, Iowa - - 2014
The automated correct segmentation of left and right lungs is a nontrivial problem, because the tissue layer between both lungs can be quite thin. In the case of lung segmentation with left and right lung models, overlapping segmentations can occur. In this paper, the authors address this issue and propose ...
Wang Fengfeng F Department of Health Technology and Informatics, Hong Kong Polytechnic University, Hong Kong, - - 2014
EGFR signaling pathway and microRNAs (miRNAs) are two important factors for development and treatment in non-small cell lung cancer (NSCLC). Microarray analysis enables the genome-wide expression profiling. However, the information from microarray data may not be fully deciphered through the existing approaches. In this study we present an mRNA:miRNA stepwise ...
Valeri Linda L Department of Biostatistics and Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA, 02115, - - 2014
Mediation analysis is a popular approach to examine the extent to which the effect of an exposure on an outcome is through an intermediate variable (mediator) and the extent to which the effect is direct. When the mediator is mis-measured, the validity of mediation analysis can be severely undermined. In ...
Dharmakumara Mahesh M The Alfred Hospital - - 2014
Inert gas washout measurements using oxygen, in the lungs of small animals are complicated by the continuous process of oxygen consumption (VO2). The Multiple Breath Nitrogen Washout (MBNW) technique uses the alveolar slope to determine measures of ventilation inhomogeneity in the acinar (Sacin) and conducting (Scond) airway regions, as well ...
Shao Yeqin - - 2014
Lung field segmentation in the posterior-anterior (PA) chest radiograph is important for pulmonary disease diagnosis and hemodialysis treatment. Due to high shape variation and boundary ambiguity, accurate lung field segmentation from chest radiograph is still a challenging task. To tackle these challenges, we propose a joint shape and appearance sparse ...
Deppen Stephen A SA *Department of Surgery, Tennessee Valley Healthcare System, Veterans Affairs, Nashville, Tennessee; ††Department of Thoracic Surgery, §Department of Medicine, Division of Pulmonary and Critical Care Medicine, ¶Vanderbilt-Ingram Cancer Center, and **School of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee; †Department of Biostatistics, Vanderbilt University, Nashville, Tennessee; and ‡Department of Critical Care Medicine, ‖Department of Radiology, and #Geriatric Research Education Clinical - - 2014
Existing predictive models for lung cancer focus on improving screening or referral for biopsy in general medical populations. A predictive model calibrated for use during preoperative evaluation of suspicious lung lesions is needed to reduce unnecessary operations for a benign disease. A clinical prediction model (Thoracic Research Evaluation And Treatment ...
Falzarano Darryl D Disease Modeling and Transmission, Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, Montana, United States of - - 2014
The availability of a robust disease model is essential for the development of countermeasures for Middle East respiratory syndrome coronavirus (MERS-CoV). While a rhesus macaque model of MERS-CoV has been established, the lack of uniform, severe disease in this model complicates the analysis of countermeasure studies. Modeling of the interaction ...
Gupta R P RP Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College, London, - - 2014
The use of different spirometric definitions for chronic obstructive pulmonary disease (COPD) has made an informative review of the available prevalence surveys impossible. To derive adjustment factors that allow the comparison of studies using different spirometric criteria. Pre- and post-bronchodilator one-second forced expiratory volume (FEV1) and forced vital capacity (FVC) ...
Montrikittiphant Thanit T Department of Chemistry, Imperial College London, South Kensington Campus, SW7 2AZ, London, UK; Polymer and Composite Engineering (PaCE) group, Department of Chemical Engineering, Imperial College London, South Kensington Campus, SW7 2AZ, London, - - 2014
Bacterial cellulose (BC) is often regarded as a prime candidate nano-reinforcement for the production of renewable nanocomposites. However, the mechanical performance of most BC nanocomposites is often inferior compared with commercially available polylactide (PLLA). Here, the manufacturing concept of paper-based laminates is used, i.e., "PaPreg," to produce BC nanopaper reinforced ...
Lum Kirsten J KJ Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, DHHS, Rockville, MD 20852, USA and Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, - - 2014
Prospective pregnancy studies are a valuable source of longitudinal data on menstrual cycle length. However, care is needed when making inferences of such renewal processes. For example, accounting for the sampling plan is necessary for unbiased estimation of the menstrual cycle length distribution for the study population. If couples can ...
Pond Gregory J GJ Environmental Assessment and Innovation Division, Office of Monitoring and Assessment Region III, U.S. Environmental Protection Agency, 1060 Chapline St., Wheeling, WV, 26003, USA, - - 2014
Recent studies have documented adverse effects to biological communities downstream of mountaintop coal mining and valley fills (VF), but few data exist on the longevity of these impacts. We sampled 15 headwater streams with VFs reclaimed 11-33 years prior to 2011 and sampled seven local reference sites that had no VFs. ...
Shon Kilhwan K Department of Ophthalmology, College of Medicine, University of Ulsan, Asan Medical Center , Seoul , Korea - - 2014
Abstract Purpose: To evaluate whether pointwise regression analysis of serial measures of retinal sensitivity can predict future visual field (VF) loss. Methods: Medical records of 158 patients with glaucomatous eyes with at least 6 years follow-up and 10 reliable VF exams were retrospectively analyzed. The entire follow-up period was divided ...
Bhattacharya Pinaki P School of Mechanical Engineering, Purdue University, West Lafayette, IN 47907 - - 2014
Computational models of vocal fold (VF) vibration are becoming increasingly sophisticated, their utility currently transiting from exploratory research to predictive research. However, validation of such models has remained largely qualitative, raising questions over their applicability to interpret clinical situations. In this paper, a computational model with a segregated implementation is ...
Deng Lisha L Devers Eye, Legacy Research Institute, 1225 NE 2nd Ave, portland, OR, 97232, United - - 2014
Purpose: To reduce variability and improve measurements of true change signal in visual field (VF) assessments through the use of filters that combine both functional and structural test results. Methods: Humphrey VF data (SITA Std, 24-2) and confocal scanning laser ophthalmoscopy (HRT) data from 1057 eyes of 637 participants were ...
Boggia Antonio A University of Perugia, Borgo XX Giugno, 74, 06121 Perugia, Italy. Electronic address: - - 2014
Rural Development is a priority in Europe and it is supported by specific, financial programmes. At the same time, sustainability is the key word for the European Union to construct programmes and policies for all human activities. However, measuring sustainability of rural areas is not easy, due to their particular ...
Mohiuddin Syed - - 2014
The surgical insertion of Ventilation Tubes (VTs) for the management of persistent bilateral Otitis Media with Effusion (OME) in children remains a contentious issue due to the varying opinions regarding the risks and benefits of this procedure. The aim of this study was to evaluate the economic impact of VTs ...
Hoekstra Arjen Y AY Twente Water Centre, Institute for Innovation and Governance Studies, University of Twente, Enschede, Netherlands. - - 2014
Within the context of Earth's limited natural resources and assimilation capacity, the current environmental footprint of humankind is not sustainable. Assessing land, water, energy, material, and other footprints along supply chains is paramount in understanding the sustainability, efficiency, and equity of resource use from the perspective of producers, consumers, and ...
Naganawa Mika M PET Center, Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, CT, USA. Electronic address: - - 2014
Kappa opioid receptors (KOR) are implicated in several brain disorders. In this report, a first-in-human Positron Emission Tomography (PET) study was conducted with the potent and selective KOR agonist tracer, [(11)C]GR103545, to determine an appropriate kinetic model for analysis of PET imaging data and assess the test-retest reproducibility of model-derived ...
Fenichel Eli P EP Yale University, New Haven, CT, USA, - - 2014
Developing a quantitative science of sustainability requires bridging mathematical concepts from fields contributing to sustainability science. The concept of substitutability is central to sustainability but is defined differently by different fields. Specifically, economics tends to define substitutability as a marginal concept while fields such as ecology tend to focus on ...
Sturm Robert R Brunnleitenweg 41, A-5061 Elsbethen, Salzburg, - - 2014
In the past decades, aerosol bolus inhalation increasingly came into the focus of medical interest due to its potential as a non-invasive technique for the diagnosis of lung diseases. The experimental studies were accompanied by the development of theoretical contributions dealing with aerosol bolus behaviour in healthy and diseased lungs. ...
Bhattacharya Pinaki P School of Mechanical Engineering, Purdue University, West Lafayette, IN 47907, - - 2014
Predicting phonation conditions that are benign to voice health remains a biomechanically relevant problem. Our objective is to provide insight into vocal fold (VF) hydration based on continuum-based VF models that are able to compute VF stresses during phonation and a scheme for the extraction and generalization of such computational ...
Xue Qian Q Department of Mechanical Engineering, University of Maine, Orono, - - 2014
The present study explores the use of a continuum-based computational model to investigate the effect of left-right tension imbalance on vocal fold (VF) vibrations and glottal aerodynamics, as well as its implication on phonation. The study allows us to gain new insights into the underlying physical mechanism of irregularities induced ...
Hubbard William Brad WB Virginia Polytechnic and State University, - - 2014
While protective measures have been taken to mitigate injury to the thorax during a blast exposure, primary blast lung injury (PBLI) is still evident in mounted/in vehicle cases during military conflicts. Moreover, civilians, who are unprotected from blast exposure, can be severely harmed by terrorist attacks that use improvised explosive ...
Pritchard Duncan D Aran Hall School; Bangor - - 2014
Behavioral Momentum Theory (BMT) has inspired animal models of treatment relapse. We translated the models of reinstatement and resurgence into clinical procedures to test whether relapse tests would replicate behavior pattern found in basic research. Following multiple schedule baseline reinforcement of a 16-year-old male's problem behavior at equal rates by ...
Owen David R DR Division of Brain Sciences, Department of Medicine, Imperial College, London, - - 2014
Positron emission tomography (PET) targeting the 18 kDa translocator protein (TSPO) is used to quantify neuroinflammation. Translocator protein is expressed throughout the brain, and therefore a classical reference region approach cannot be used to estimate binding potential (BPND). Here, we used blockade of the TSPO radioligand [(11)C]PBR28 with the TSPO ligand ...
Broggio D D *Institut de Radioprotection et de Sûreté Nucléaire, IRSN/PRP-HOM/SDI/LEDI 92262 Fontenay-aux-Roses Cedex, France; †AREVA NC, Etablissement de la Hague, Laboratoire de Biologie Médicale, 50444 Beaumont-Hague Cedex, France; ‡Service d'Imagerie Pédiatrique, CHU Bicêtre, AP-HP, Paris, - - 2014
The thickness and fat fraction of the chest wall are important parameters for in vivo lung monitoring. They have been measured from ultrasonic images on 374 male workers of the French nuclear industry using four measurement locations, as dictated by the size and position of the germanium detectors used for ...
Castilla Ana E AE a Assistant Professor, Department of Orthodontics, Oregon Health & Science University, Portland, - - 2014
Abstract Objective: To measure and compare bracket transfer accuracy of five indirect bonding (IDB) techniques. Materials and Methods: Five IDB techniques were studied: double polyvinyl siloxane (double-PVS), double vacuum-form (double-VF), polyvinyl siloxane vacuum-form (PVS-VF), polyvinyl siloxane putty (PVS-putty), and single vacuum-form (single-VF). Brackets were bonded on 25 identical stone working ...
Rusjan Pablo M PM Research Imaging Centre, Centre for Addiction and Mental Health (CAMH), Toronto, Ontario, - - 2014
This article describes the kinetic modeling of [(11)C]SL25.1188 ([(S)-5-methoxymethyl-3-[6-(4,4,4-trifluorobutoxy)-benzo[d]isoxazol-3-yl]-oxazolidin-2-[(11)C]one]) binding to monoamine oxidase B (MAO-B) in the human brain using high-resolution positron emission tomography (PET). Seven healthy subjects underwent two separate 90- minute PET scans after an intravenous injection of [(11)C]SL25.1188. Complementary arterial blood sampling was acquired. Radioactivity was quickly eliminated ...
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