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Kahoul Riad R Novadiscovery SAS, 60 Avenue Rockefeller, 69008 Lyon, France UMR 5558, Laboratoire de Biométrie et Biologie Evolutive, CNRS, UCB Lyon 1 - Bât. Grégor Mendel, 43 bd du 11 novembre 1918, 69622 Villeurbanne cedex, France - - 2014
Healthcare authorities make difficult decisions about how to spend limited budgets for interventions that guarantee the best cost-efficacy ratio. We propose a novel approach for treatment decision-making, OMES-in French: Objectif thérapeutique Modèle Effet Seuil (in English: Therapeutic Objective-Threshold-Effect Model; TOTEM). This approach takes into consideration results from clinical trials, adjusted ...
Loehlin John C JC University of Texas at Austin, Austin, TX, - - 2014
Rotations of 1 to 12 factors were compared by Goldberg's "bass-ackward" method, with or without initially holding constant one or more principal components. Two sets of data were employed: ratings by 320 undergraduates using 435 personality-descriptive adjectives, and 512 Oregon community members' responses to 184 scales from 8 personality inventories. ...
Calabrese Edward J EJ a  Department of Public Health, Environmental Health Sciences, University of Massachusetts, Amherst, Massachusetts 01003; - - 2014
This article explores the origin of the linear no-threshold (LNT) dose-response model and how it came to be used in cancer risk assessment worldwide. Following this historical appraisal is an evaluation of the LNT model, within the framework of the BEIR VII report of the National Academy of Sciences, on ...
Dalgleish Tracy L TL Greenbelt Family Health Team, Ottawa Couple and Family - - 2014
In emotionally focused couple therapy (EFT), the blamer-softening event helps individuals express and respond to partners' unmet attachment needs. This study examined the impact of this event in relation to attachment at intake and changes in marital satisfaction from pre- to posttherapy. Thirty-two couples were provided an average of 21 ...
Nifong James C JC Department of Biology, University of Florida, Gainesville, Florida, - - 2014
1.Large-bodied, top-predators are often highly mobile, with the potential to provide important linkages between spatially distinct food webs. What biological factors contribute to variation in cross-ecosystem movements, however, have rarely been examined. 2.Here, we investigated how ontogeny (body size), sex, and individual-level behavior impacts intra-population variation in cross-ecosystem foraging (i.e., ...
Gates M - - 2014
Many economically important cattle diseases spread between herds through livestock movements. Traditionally, most transmission models have assumed that all purchased cattle carry the same risk of generating outbreaks in the destination herd. Using data on bovine viral diarrhoea virus (BVDV) in Scotland as a case example, this study provides empirical ...
Lewsey J D JD Health Economics and Health Technology Assessment, Institute of Health & Wellbeing, University of Glasgow, Glasgow, - - 2014
A policy model is a model that can evaluate the effectiveness and cost-effectiveness of interventions and inform policy decisions. In this study, we introduce a cardiovascular disease (CVD) policy model which can be used to model remaining life expectancy including a measure of socioeconomic deprivation as an independent risk factor ...
Riley Julia L JL Laurentian University, - - 2014
Many temperate animals spend half their lives in a non-active, overwintering state, and multiple adaptations have evolved to enable winter survival. One notable vertebrate model is Chrysemys picta whose hatchlings display dichotomous overwintering strategies: some hatchlings spend their first winter aquatically after nest emergence in fall, while others overwinter terrestrially ...
Popescu Andrei-Alin AA University of East Anglia; - - 2014
Population structure is a confounding factor in Genome Wide Association Studies, increasing the rate of false positive associations. In order to correct for it, several model-based algorithms such as ADMIXTURE and STRUCTURE have been proposed. These tend to suffer from the fact that they have a considerable computational burden, limiting ...
Xu Zhenggang Z Dongting Lake Station for Wetland Ecosystem Observation and Research, Key Laboratory of Agro-ecological Process in Subtropical Region, Institute of Subtropical Agriculture, The Chinese Academy of Sciences, Changsha, Hunan, 410125, PR China; Hu Nan City University, Yiyang, Hunan, 413000, PR - - 2014
Rodent pests severely damage agricultural crops. Outbreak risk models of rodent pests often do not include sufficient information regarding geographic variation. Habitat plays an important role in rodent-pest outbreak risk, and more information about the relationship between habitat and crop protection is urgently needed. The goal of the present study ...
Lin Kai K 1 Tungnan - - 2014
Summary.-The importance of psychological skills to an athlete is widely recognized. The Athletic Psychological Skills Inventory (APSI) was developed to evaluate psychological skills in the Taiwanese sports environment. This study employed the APSI model to refine the psychological skill factor structure. The model was supported as a reliable and valid ...
Zhou Meng M College of Life Science, Jilin University, Changchun 130012, P. R. China. - - 2014
The complex traits of an organism are associated with a complex interplay between genetic factors (GFs) and environmental factors (EFs). However, compared with protein-coding genes and microRNAs, there is a paucity of computational methods and bioinformatic resource platform for understanding the associations between lncRNA and EF. In this study, we ...
Stuart Elizabeth A EA Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA, - - 2014
Recent years have seen increasing interest in and attention to evidence-based practices, where the "evidence" generally comes from well-conducted randomized trials. However, while those trials yield accurate estimates of the effect of the intervention for the participants in the trial (known as "internal validity"), they do not always yield relevant ...
Collevatti Rosane G - - 2014
BackgroundGlaciations were recurrent throughout the Quaternary and potentially shaped species genetic structure worldwide by affecting population dynamics. Here, we implemented a multi-model inference approach to recover the distribution dynamics and demographic history of a Neotropical savanna tree, Tabebuia aurea (Bignoniaceae). Exploring different algorithms and paleoclimatic simulations, we used ecological niche ...
Chowell Gerardo - - 2014
The complex and unprecedented Ebola epidemic ongoing in West Africa has highlighted the need to review the epidemiological characteristics of Ebola Virus Disease (EVD) as well as our current understanding of the transmission dynamics and the effect of control interventions against Ebola transmission. Here we review key epidemiological data from ...
Walters William A WA Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, CO 80309, - - 2014
Recent studies have linked human gut microbes to obesity and inflammatory bowel disease, but consistent signals have been difficult to identify. Here we test for indicator taxa and general features of the microbiota that are generally consistent across studies of obesity and of IBD, focusing on studies involving high-throughput sequencing ...
Vinkhuyzen A A E AA The University of Queensland, Queensland Brain Institute,St Lucia,QLD - - 2014
G × E in psychiatry may explain why environmental risk factors have big impact in some individuals but not in others, and conversely why relatives that are genetically at risk for disease do not all develop disease. Here we discuss two novel methods that use an aggregate genome-wide measure of genetic risk ...
Veronese E E Department of Information Engineering, University of Padova, Via Gradenigo 6/b,35100 Padova, - - 2014
Prenatal events such as intrauterine growth restriction and increased cardiovascular risk in later life have been shown to be associated with an increased intima-media thickness (aIMT) of the abdominal aorta in the fetus. In order to assess and manage atherosclerosis and cardiovascular disease risk in adults and children, in recent ...
Stults Cheryl L M CL Novartis Pharmaceuticals Corp, San Carlos, California, - - 2014
To incorporate quality by design concepts into the management of leachables, an emphasis is often put on understanding the extractable profile for the materials of construction for manufacturing disposables, container-closure, or delivery systems. Component manufacturing processes may also impact the extractable profile. An approach was developed to (1) identify critical ...
Green Mark A MA School of Health and Related Research (ScHARR), University of Sheffield, Sheffield, UK. Electronic address: - - 2014
The paper provides an overview of a neighbourhood level classification of mortality for England and Wales (2006-2009). Standardised mortality ratios for 63 causes of death were calculated for middle super output areas (weighted by prevalence). A k-means partitional method was used to classify the data. An eight cluster solution was ...
Styck Kara M KM University of Texas at San Antonio, USA - - 2014
To evaluate the structural validity of the Wechsler Intelligence Scale for Children-Fourth Edition (WISC-IV). Confirmatory factor analyses were applied to a sample of 233 students diagnosed with ADHD by school multidisciplinary evaluation teams to evaluate the relative fit of the following competing models: (a) one factor, (b) two oblique verbal ...
Chen Xiaoxiao - - 2014
Metabolic Syndrome (MS) is increasingly becoming a major worldwide clinical and public health issue. Thus it is extremely important to study the history of MS and search for the most likely component contributing to start the cascade of confusions of MS. A longitudinal cohort was involved which included the data ...
Smith Stephanie D SD Yale School of Medicine, Child Study Center, 230 South Frontage Road, Box 207900, New Haven, CT, 06520-7900, USA, - - 2014
This study evaluated multiple facets of self-perceptions that have been theorized and shown to play a contributory role in the development of aggression for less clinically severe populations in a sample of youths from the juvenile justice system. Independent and unique associations of low self-esteem and inflated self-perceptions with aggression ...
Huang R R Interdisciplinary Program for the PhD in Urban Design and Planning, University of Washington, Seattle, WA, USA; The Urban Form Lab (UFL), Department of Urban Design and Planning, University of Washington, Seattle, WA, - - 2014
Obesity rates in the USA show distinct geographical patterns. The present study used spatial cluster detection methods and individual-level data to locate obesity clusters and to analyse them in relation to the neighbourhood built environment. The 2008-2009 Seattle Obesity Study provided data on the self-reported height, weight, and sociodemographic characteristics ...
Niu Geng G Research Institute of Economics and Management (RIEM), Southwestern University of Finance and Economics, Chengdu, People's Republic of China, 610074, - - 2014
The vast literature on extrapolative stochastic mortality models focuses mainly on the extrapolation of past mortality trends and summarizes the trends by one or more latent factors. However, the interpretation of these trends is typically not very clear. On the other hand, explanation methods are trying to link mortality dynamics ...
Han Baoguang B Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, 46285, - - 2014
Semicompeting risks data arise when two types of events, non-terminal and terminal, are observed. When the terminal event occurs first, it censors the non-terminal event, but not vice versa. To account for possible dependent censoring of the non-terminal event by the terminal event and to improve prediction of the terminal ...
Golan David D Department of Statistics, Tel Aviv University, Tel Aviv 69978, Israel. Electronic address: - - 2014
For predicting genetic risk, we propose a statistical approach that is specifically adapted to dealing with the challenges imposed by disease phenotypes and case-control sampling. Our approach (termed Genetic Risk Scores Inference [GeRSI]), combines the power of fixed-effects models (which estimate and aggregate the effects of single SNPs) and random-effects ...
Pei Xiaobing - - 2014
In this paper, a novel projective nonnegative matrix factorization (PNMF) method for enhancing the clustering performance is presented, called automated graph regularized projective nonnegative matrix factorization (AGPNMF). The idea of AGPNMF is to extend the original PNMF by incorporating the automated graph regularized constraint into the PNMF decomposition. The key ...
Lagoa Constantino M CM Department of Electrical Engineering, The Pennsylvania State - - 2014
Adaptive intensive interventions are introduced, and new methods from the field of control engineering for use in their design are illustrated. A detailed step-by-step explanation of how control engineering methods can be used with intensive longitudinal data to design an adaptive intensive intervention is provided. The methods are evaluated via ...
Peeters Carel F W CF Department of Epidemiology & Biostatistics, VU University Medical Center, Amsterdam, The Netherlands. Electronic address: - - 2014
Factor analysis (FA) has become part and parcel in metabolic syndrome (MBS) research. Both exploration- and confirmation-driven factor analyzes are rampant. However, factor analytic results on MBS differ widely. A situation that is at least in part attributable to misapplication of FA. Here, our purpose was (i) to review factor ...
Li Li-Xin - - 2014
Nonnegative matrix factorization (NMF) has recently become a very popular unsupervised learning method because of its representational properties of factors and simple multiplicative update algorithms for solving the NMF. However, for the common NMF approach of minimizing the Euclidean distance between approximate and true values, the convergence of multiplicative update ...
Gross Georgina M GM Department of Psychology, University of North Carolina at - - 2014
Schizotypy is a multidimensional construct that captures the expression of schizophrenic symptoms and impairment from subclinical levels to full-blown psychosis. The present study examined the comparability of the factor structure of 2 leading psychometric measures of schizotypy: the Wisconsin Schizotypy Scales (WSS) and the Schizotypal Personality Questionnaire (SPQ). Both the ...
Le Bourlot Vincent V Institut de Biologie de l'École Normale Supérieure, CNRS Unité Mixte de Recherche (UMR) 8197, Institut National de la Santé et de la Recherche Médicale U1024, 46 Rue d'Ulm, 75005 Paris, France; and Centre d'Enseignement et de Recherches sur l'Environnement et la Société-Environmental Research and Teaching Institute, École Normale Supérieure, 24 Rue Lhomond, 75005 Paris, - - 2014
Abstract Competition is a major regulatory factor in population and community dynamics. Its effects can be either direct in interference competition or indirect in exploitative competition. The impact of exploitative competition on population dynamics has been extensively studied from empirical and theoretical points of view, but the consequences of interference ...
Ahmed Armin A Department of Critical Care Medicine, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, - - 2014
Over past few years, treatment of invasive candidiasis (IC) has evolved from targeted therapy to prophylaxis, pre-emptive and empirical therapy. Numerous predisposing factors for IC have been grouped together in various combinations to design risk prediction models. These models in general have shown good negative predictive value, but poor positive ...
Yu Yu Y Department of Social Medicine and Health Management, Public Health School, Central South University, Upper Mayuanlin Road 238, Changsha, 410008, Hunan, - - 2014
Evaluation and comparison of the factor structure of the Medical Outcomes Study Social Support Survey (MOS-SSS) using both confirmatory factor analysis (CFA) and exploratory factor analysis (EFA) with two samples of people living with HIV/AIDS in China. Secondary analyses were conducted with data from two comparable samples of 320 people ...
Mao Chunhong C Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, VA 24061, USA - - 2014
Motivation: We've developed a highly curated bacterial virulence factor library in PATRIC (Pathosystems Resource Integration Center, www.patricbrc.org) to support infectious disease research. Although several virulence factor databases are available, there is still a need to incorporate new knowledge found in published experimental evidence and integrate this data with other information ...
Kilgus Stephen P - - 2014
The purpose of this investigation was to evaluate the models for interpretation and use that serve as the foundation of an interpretation/use argument for the Social and Academic Behavior Risk Screener (SABRS). The SABRS was completed by 34 teachers with regard to 488 students in a Midwestern high school during ...
Islam M Mofizul - - 2014
Out of pocket expenditure (OOPE) on healthcare is related to the burden of illness and the number of chronic conditions a patient experiences, but the relationship of these costs to particular conditions and groups of conditions is less studied. This study examines the effect on OOPE of various morbidity groupings, ...
Yuan Zhi Z Safety and Risk Engineering Group (SREG), Faculty of Engineering & Applied Science, Memorial University of Newfoundland, St. John's, NL, Canada, A1B - - 2014
In this study, a methodology has been proposed for risk analysis of dust explosion scenarios based on Bayesian network. Our methodology also benefits from a bow-tie diagram to better represent the logical relationships existing among contributing factors and consequences of dust explosions. In this study, the risks of dust explosion ...
Pasquali Sara S CNR-IMATI, Via Bassini 15, 20133, Milano, - - 2014
The introduction of invasive species causes damages from the economic and ecological point of view. Interception of plant pests and eradication of the established populations are two management options to prevent or limit the risk posed by an invasive species. Management options generate costs related to the interception at the ...
Rizzo John A JA Stony Brook - - 2014
Abstract Motivation: Differences in cost of illness (COI) methodological approaches have led to disparate results. This analysis examines two sources of this variation: specification of comorbidities in the estimated cost models and assumed prevalence rates used for generating aggregate costs. The study provides guidance in determining which comorbidities are important ...
Ortega Hinojosa Alberto M AM University of California, Berkeley, School of Public Health, Division of Environmental Health Sciences, 50 University Hall MC7360 Mail Drop, Berkeley, CA 94720-7360, United States. Electronic address: - - 2014
Globally and in the United States, smoking and obesity are leading causes of death and disability. Reliable estimates of prevalence for these risk factors are often missing variables in public health surveillance programs. This may limit the capacity of public health surveillance to target interventions or to assess associations between ...
Bae Jong-Myon JM Jeju National University School of Medicine, Jeju, - - 2014
The concept of meta-epidemiology has been introduced with considering the methodological limitations of systematic review for intervention trials. The paradigm of meta-epidemiology has shifted from a statistical method into a new methodology to close gaps between evidence and practice. Main interest of meta-epidemiology is to control potential biases in previous ...
Thalji Nassir M NM Division of Cardiovascular Surgery, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, - - 2014
Surgical risk models estimate operative outcomes while controlling for heterogeneity in 'case mix' within and between institutions. In cardiac surgery, risk models are used for patient counselling, surgical decision-making, clinical research, quality assurance and improvement, and financial reimbursement. Importantly, risk models are only as good as the databases from which ...
Biehler Jonas J Institute for Computational Mechanics, Technische Universität München, Boltzmannstr. 15, 85747, Garching b. München, - - 2014
In simulation of cardiovascular processes and diseases patient-specific model parameters, such as constitutive properties, are usually not easy to obtain. Instead of using population mean values to perform "patient-specific" simulations, thereby neglecting the inter- and intra-patient variations present in these parameters, these uncertainties have to be considered in the computational ...
Ewart Lorna L AstraZeneca R&D Mölndal, Pepparedsleden 1, 431 83, Mölndal, - - 2014
It is widely accepted that more needs to be done to bring new, safe and efficacious drugs to the market. Cardiovascular toxicity detected both in early drug discovery as well as in the clinic, is a major contributor to the high failure rate of new molecules. The growth of translational ...
Fleetcroft Robert - - 2014
Statins are an important intervention for primary and secondary cardiovascular disease (CVD) prevention. We aimed to establish the variation in primary preventive treatment for CVD with statins in the English population. Cross sectional analyses of 6155 English primary care practices with 40,017,963 patients in 2006/7. Linear regression was used to ...
de Oña Juan J TRYSE Research Group, Department of Civil Engineering, University of Granada, Cuesta del Hospicio, 18071 Granada, Spain. Electronic address: - - 2014
Road crashes can be caused by different factors, including infrastructure, vehicles, and human variables. Many research studies have focused solely on identifying the key factors that cause road crashes. From these studies, it emerged that human factors have the most relevant impact on accident severity. More specifically, accident severity depends ...
Cox Jonathan - - 2014
Accurate malaria stratification is essential for effective targeting of interventions but represents a particular challenge in pre-elimination settings. In these settings transmission is typically sufficiently low and spatially heterogeneous to warrant a need for estimates of malaria risk at sub-district or village level but is also likely to be sufficiently ...
van der Zwan Yvonne G YG Department of Pathology, Erasmus MC - University Medical Centre Rotterdam, Rotterdam, The - - 2014
A disturbed process of gonadal formation and maintenance may result in testicular dysgenesis syndrome or disorders of sex development (DSDs), with an increased germ cell cancer (GCC) risk. Early diagnosis and treatment requires the identification of relevant risk factors and initial pathologic stages. To evaluate current knowledge and novel insights ...
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