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Kahoul Riad R Novadiscovery SAS, 60 Avenue Rockefeller, 69008 Lyon, France UMR 5558, Laboratoire de Biométrie et Biologie Evolutive, CNRS, UCB Lyon 1 - Bât. Grégor Mendel, 43 bd du 11 novembre 1918, 69622 Villeurbanne cedex, France - - 2014
Healthcare authorities make difficult decisions about how to spend limited budgets for interventions that guarantee the best cost-efficacy ratio. We propose a novel approach for treatment decision-making, OMES-in French: Objectif thérapeutique Modèle Effet Seuil (in English: Therapeutic Objective-Threshold-Effect Model; TOTEM). This approach takes into consideration results from clinical trials, adjusted ...
Loehlin John C JC University of Texas at Austin, Austin, TX, - - 2014
Rotations of 1 to 12 factors were compared by Goldberg's "bass-ackward" method, with or without initially holding constant one or more principal components. Two sets of data were employed: ratings by 320 undergraduates using 435 personality-descriptive adjectives, and 512 Oregon community members' responses to 184 scales from 8 personality inventories. ...
Allen Timothy Eric Harry - - 2014
Consumer and environmental safety decisions are based on exposure and hazard data, interpreted using risk assessment approaches. The adverse outcome pathway (AOP) conceptual framework has been presented as a logical sequence of events or processes within biological systems which can be used to understand adverse effects and refine current risk ...
Campagna Jesse J Texas Department of State Health Services, PO Box 149347, Austin, TX, 78756, - - 2014
This analysis presents a method for estimating the population of men who have sex with men (MSM) at the county and metropolitan area level in Texas. Surveillance data consistently demonstrate that MSM experience a high burden of HIV and other sexually transmitted infections (STIs). Numerous studies have shown that MSM ...
Park Gyung-Min GM From the Department of Cardiology, Daejeon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Daejeon, Korea (G.-M.P., S.H.H.); Departments of Biostatistics (S.H., J.B.L., M.S.L.), Preventive Medicine (M.-W.J.), Cardiology, (J.-M.A., S.-W.L., Y.-H.K., S.-W.P., S,-J.P.), Endocrinology and Metabolism (B.-J.K., J.-M.K.), and Health Screening and Promotion Center (H.-K.K., J.C.), Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea; Department of Nursing, College of Medicine, Dankook University, Cheonan, Korea (S.H.K.); Department of Preventive Medicine, Yonsei University College of Medicine, Seoul, Korea (H.C.K.); and Research and Development Center, Health Insurance Review and Assessment Service, Seoul, Korea - - 2014
A model for predicting cardiovascular disease in Asian populations is limited. In total, 57 393 consecutive asymptomatic Korean individuals aged 30 to 80 years without a prior history of cardiovascular disease who underwent a general health examination were enrolled. Subjects were randomly classified into the train (n=45 914) and validation ...
Gabriel Erin E EE Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, - - 2014
Principal surrogate endpoints are useful as targets for phase I and II trials. In many recent trials, multiple post-randomization biomarkers are measured. However, few statistical methods exist for comparison of or combination of biomarkers as principal surrogates, and none of these methods to our knowledge utilize time-to-event clinical endpoint information. ...
Chang Xiaohui X College of Business, Oregon State University, Corvallis, Oregon, - - 2014
We propose a novel statistical framework by supplementing case-control data with summary statistics on the population at risk for a subset of risk factors. Our approach is to first form two unbiased estimating equations, one based on the case-control data and the other on both the case data and the ...
Gwak Kwan-Woong KW Department of Mechanical Engineering, Sejong University, Seoul, - - 2014
Physiological feasibility is the most important requirement for cardiovascular circulatory simulators (CCSs). However, previous simulators have been validated by a comparison with specific human data sets, which are valid only for very limited conditions, and so it is difficult to validate the fidelity of a CCS for various body conditions. ...
Bradshaw Corey J A CJ The Environment Institute and School of Earth and Environmental Sciences, The University of Adelaide, Adelaide, SA 5005, Australia - - 2014
The inexorable demographic momentum of the global human population is rapidly eroding Earth's life-support system. There are consequently more frequent calls to address environmental problems by advocating further reductions in human fertility. To examine how quickly this could lead to a smaller human population, we used scenario-based matrix modeling to ...
Furukawa Kyoji K Radiation Effects Research Foundation, Hiroshima, Japan - - 2014
While data are unavoidably missing or incomplete in most observational studies, consequences of mishandling such incompleteness in analysis are often overlooked. When time-varying information is collected irregularly and infrequently over a long period, even precisely obtained data may implicitly involve substantial incompleteness. Motivated by an analysis to quantitatively evaluate the ...
Carriker Neil E NE Tennessee Valley Authority, 6401 Harbor Master Drive, Hixson, TN, 37343. - - 2014
The Tennessee Valley Authority conducted a Baseline Ecological Risk Assessment (BERA) for the Kingston Fossil Plant ash release site to evaluate potential effects of residual coal ash on biota in Watts Bar Reservoir, Tennessee. The BERA was in response to a release of 4.1 million m(3) of coal ash on ...
Wu Yufeng Y Department of Computer Science and Engineering, University of Connecticut, Storrs, CT 06269, U.S.A. - - 2014
Population trees represent past population divergence histories. The inference of population trees can be useful for the study of population evolution. With the size of data increases in large-scale population genetic projects, such as the 1000 Genomes Project, there are new computational challenges for ancestral population inference, including population tree ...
Holland R C RC The Institute of Fundamental Sciences, Massey University,Palmerston North,New - - 2014
SUMMARY The search for an association between disease incidence and possible risk factors using surveillance data needs to account for possible spatial and temporal correlations in underlying risk. This can be especially difficult if there are missing values for some important covariates. We present a case study to show how ...
Dickson E D ED United States Nuclear Regulatory Commission, Rockville, - - 2014
This paper presents validated building shielding factors designed for contemporary US housing-stock under an idealized, yet realistic, exposure scenario within a semi-infinite cloud of radioactive material. The building shielding factors are intended for use in emergency planning and level three probabilistic risk assessments for a variety of postulated radiological events ...
Calabrese Edward J EJ a  Department of Public Health, Environmental Health Sciences, University of Massachusetts, Amherst, Massachusetts 01003; - - 2014
This article explores the origin of the linear no-threshold (LNT) dose-response model and how it came to be used in cancer risk assessment worldwide. Following this historical appraisal is an evaluation of the LNT model, within the framework of the BEIR VII report of the National Academy of Sciences, on ...
Dalgleish Tracy L TL Greenbelt Family Health Team, Ottawa Couple and Family - - 2014
In emotionally focused couple therapy (EFT), the blamer-softening event helps individuals express and respond to partners' unmet attachment needs. This study examined the impact of this event in relation to attachment at intake and changes in marital satisfaction from pre- to posttherapy. Thirty-two couples were provided an average of 21 ...
Oneto Luca - - 2014
The purpose of this paper is to obtain a fully empirical stability-based bound on the generalization ability of a learning procedure, thus, circumventing some limitations of the structural risk minimization framework. We show that assuming a desirable property of a learning algorithm is sufficient to make data-dependency explicit for stability, ...
Nifong James C JC Department of Biology, University of Florida, Gainesville, Florida, - - 2014
1.Large-bodied, top-predators are often highly mobile, with the potential to provide important linkages between spatially distinct food webs. What biological factors contribute to variation in cross-ecosystem movements, however, have rarely been examined. 2.Here, we investigated how ontogeny (body size), sex, and individual-level behavior impacts intra-population variation in cross-ecosystem foraging (i.e., ...
Gates M - - 2014
Many economically important cattle diseases spread between herds through livestock movements. Traditionally, most transmission models have assumed that all purchased cattle carry the same risk of generating outbreaks in the destination herd. Using data on bovine viral diarrhoea virus (BVDV) in Scotland as a case example, this study provides empirical ...
Lewsey J D JD Health Economics and Health Technology Assessment, Institute of Health & Wellbeing, University of Glasgow, Glasgow, - - 2014
A policy model is a model that can evaluate the effectiveness and cost-effectiveness of interventions and inform policy decisions. In this study, we introduce a cardiovascular disease (CVD) policy model which can be used to model remaining life expectancy including a measure of socioeconomic deprivation as an independent risk factor ...
Riley Julia L JL Laurentian University, - - 2014
Many temperate animals spend half their lives in a non-active, overwintering state, and multiple adaptations have evolved to enable winter survival. One notable vertebrate model is Chrysemys picta whose hatchlings display dichotomous overwintering strategies: some hatchlings spend their first winter aquatically after nest emergence in fall, while others overwinter terrestrially ...
Popescu Andrei-Alin AA University of East Anglia; - - 2014
Population structure is a confounding factor in Genome Wide Association Studies, increasing the rate of false positive associations. In order to correct for it, several model-based algorithms such as ADMIXTURE and STRUCTURE have been proposed. These tend to suffer from the fact that they have a considerable computational burden, limiting ...
Xu Zhenggang Z Dongting Lake Station for Wetland Ecosystem Observation and Research, Key Laboratory of Agro-ecological Process in Subtropical Region, Institute of Subtropical Agriculture, The Chinese Academy of Sciences, Changsha, Hunan, 410125, PR China; Hu Nan City University, Yiyang, Hunan, 413000, PR - - 2014
Rodent pests severely damage agricultural crops. Outbreak risk models of rodent pests often do not include sufficient information regarding geographic variation. Habitat plays an important role in rodent-pest outbreak risk, and more information about the relationship between habitat and crop protection is urgently needed. The goal of the present study ...
Lin Kai K 1 Tungnan - - 2014
Summary.-The importance of psychological skills to an athlete is widely recognized. The Athletic Psychological Skills Inventory (APSI) was developed to evaluate psychological skills in the Taiwanese sports environment. This study employed the APSI model to refine the psychological skill factor structure. The model was supported as a reliable and valid ...
Zhou Meng M College of Life Science, Jilin University, Changchun 130012, P. R. China. - - 2014
The complex traits of an organism are associated with a complex interplay between genetic factors (GFs) and environmental factors (EFs). However, compared with protein-coding genes and microRNAs, there is a paucity of computational methods and bioinformatic resource platform for understanding the associations between lncRNA and EF. In this study, we ...
Stuart Elizabeth A EA Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA, - - 2014
Recent years have seen increasing interest in and attention to evidence-based practices, where the "evidence" generally comes from well-conducted randomized trials. However, while those trials yield accurate estimates of the effect of the intervention for the participants in the trial (known as "internal validity"), they do not always yield relevant ...
Collevatti Rosane G - - 2014
BackgroundGlaciations were recurrent throughout the Quaternary and potentially shaped species genetic structure worldwide by affecting population dynamics. Here, we implemented a multi-model inference approach to recover the distribution dynamics and demographic history of a Neotropical savanna tree, Tabebuia aurea (Bignoniaceae). Exploring different algorithms and paleoclimatic simulations, we used ecological niche ...
Chowell Gerardo - - 2014
The complex and unprecedented Ebola epidemic ongoing in West Africa has highlighted the need to review the epidemiological characteristics of Ebola Virus Disease (EVD) as well as our current understanding of the transmission dynamics and the effect of control interventions against Ebola transmission. Here we review key epidemiological data from ...
Walters William A WA Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, CO 80309, - - 2014
Recent studies have linked human gut microbes to obesity and inflammatory bowel disease, but consistent signals have been difficult to identify. Here we test for indicator taxa and general features of the microbiota that are generally consistent across studies of obesity and of IBD, focusing on studies involving high-throughput sequencing ...
Vinkhuyzen A A E AA The University of Queensland, Queensland Brain Institute,St Lucia,QLD - - 2014
G × E in psychiatry may explain why environmental risk factors have big impact in some individuals but not in others, and conversely why relatives that are genetically at risk for disease do not all develop disease. Here we discuss two novel methods that use an aggregate genome-wide measure of genetic risk ...
Veronese E E Department of Information Engineering, University of Padova, Via Gradenigo 6/b,35100 Padova, - - 2014
Prenatal events such as intrauterine growth restriction and increased cardiovascular risk in later life have been shown to be associated with an increased intima-media thickness (aIMT) of the abdominal aorta in the fetus. In order to assess and manage atherosclerosis and cardiovascular disease risk in adults and children, in recent ...
Stults Cheryl L M CL Novartis Pharmaceuticals Corp, San Carlos, California, - - 2014
To incorporate quality by design concepts into the management of leachables, an emphasis is often put on understanding the extractable profile for the materials of construction for manufacturing disposables, container-closure, or delivery systems. Component manufacturing processes may also impact the extractable profile. An approach was developed to (1) identify critical ...
Green Mark A MA School of Health and Related Research (ScHARR), University of Sheffield, Sheffield, UK. Electronic address: - - 2014
The paper provides an overview of a neighbourhood level classification of mortality for England and Wales (2006-2009). Standardised mortality ratios for 63 causes of death were calculated for middle super output areas (weighted by prevalence). A k-means partitional method was used to classify the data. An eight cluster solution was ...
Styck Kara M KM University of Texas at San Antonio, USA - - 2014
To evaluate the structural validity of the Wechsler Intelligence Scale for Children-Fourth Edition (WISC-IV). Confirmatory factor analyses were applied to a sample of 233 students diagnosed with ADHD by school multidisciplinary evaluation teams to evaluate the relative fit of the following competing models: (a) one factor, (b) two oblique verbal ...
Smith Stephanie D SD Yale School of Medicine, Child Study Center, 230 South Frontage Road, Box 207900, New Haven, CT, 06520-7900, USA, - - 2014
This study evaluated multiple facets of self-perceptions that have been theorized and shown to play a contributory role in the development of aggression for less clinically severe populations in a sample of youths from the juvenile justice system. Independent and unique associations of low self-esteem and inflated self-perceptions with aggression ...
Chen Xiaoxiao - - 2014
Metabolic Syndrome (MS) is increasingly becoming a major worldwide clinical and public health issue. Thus it is extremely important to study the history of MS and search for the most likely component contributing to start the cascade of confusions of MS. A longitudinal cohort was involved which included the data ...
Huang R R Interdisciplinary Program for the PhD in Urban Design and Planning, University of Washington, Seattle, WA, USA; The Urban Form Lab (UFL), Department of Urban Design and Planning, University of Washington, Seattle, WA, - - 2014
Obesity rates in the USA show distinct geographical patterns. The present study used spatial cluster detection methods and individual-level data to locate obesity clusters and to analyse them in relation to the neighbourhood built environment. The 2008-2009 Seattle Obesity Study provided data on the self-reported height, weight, and sociodemographic characteristics ...
Niu Geng G Research Institute of Economics and Management (RIEM), Southwestern University of Finance and Economics, Chengdu, People's Republic of China, 610074, - - 2014
The vast literature on extrapolative stochastic mortality models focuses mainly on the extrapolation of past mortality trends and summarizes the trends by one or more latent factors. However, the interpretation of these trends is typically not very clear. On the other hand, explanation methods are trying to link mortality dynamics ...
Han Baoguang B Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, 46285, - - 2014
Semicompeting risks data arise when two types of events, non-terminal and terminal, are observed. When the terminal event occurs first, it censors the non-terminal event, but not vice versa. To account for possible dependent censoring of the non-terminal event by the terminal event and to improve prediction of the terminal ...
Golan David D Department of Statistics, Tel Aviv University, Tel Aviv 69978, Israel. Electronic address: - - 2014
For predicting genetic risk, we propose a statistical approach that is specifically adapted to dealing with the challenges imposed by disease phenotypes and case-control sampling. Our approach (termed Genetic Risk Scores Inference [GeRSI]), combines the power of fixed-effects models (which estimate and aggregate the effects of single SNPs) and random-effects ...
Pei Xiaobing - - 2014
In this paper, a novel projective nonnegative matrix factorization (PNMF) method for enhancing the clustering performance is presented, called automated graph regularized projective nonnegative matrix factorization (AGPNMF). The idea of AGPNMF is to extend the original PNMF by incorporating the automated graph regularized constraint into the PNMF decomposition. The key ...
Lagoa Constantino M CM Department of Electrical Engineering, The Pennsylvania State - - 2014
Adaptive intensive interventions are introduced, and new methods from the field of control engineering for use in their design are illustrated. A detailed step-by-step explanation of how control engineering methods can be used with intensive longitudinal data to design an adaptive intensive intervention is provided. The methods are evaluated via ...
Peeters Carel F W CF Department of Epidemiology & Biostatistics, VU University Medical Center, Amsterdam, The Netherlands. Electronic address: - - 2014
Factor analysis (FA) has become part and parcel in metabolic syndrome (MBS) research. Both exploration- and confirmation-driven factor analyzes are rampant. However, factor analytic results on MBS differ widely. A situation that is at least in part attributable to misapplication of FA. Here, our purpose was (i) to review factor ...
Li Li-Xin - - 2014
Nonnegative matrix factorization (NMF) has recently become a very popular unsupervised learning method because of its representational properties of factors and simple multiplicative update algorithms for solving the NMF. However, for the common NMF approach of minimizing the Euclidean distance between approximate and true values, the convergence of multiplicative update ...
Gross Georgina M GM Department of Psychology, University of North Carolina at - - 2014
Schizotypy is a multidimensional construct that captures the expression of schizophrenic symptoms and impairment from subclinical levels to full-blown psychosis. The present study examined the comparability of the factor structure of 2 leading psychometric measures of schizotypy: the Wisconsin Schizotypy Scales (WSS) and the Schizotypal Personality Questionnaire (SPQ). Both the ...
Le Bourlot Vincent V Institut de Biologie de l'École Normale Supérieure, CNRS Unité Mixte de Recherche (UMR) 8197, Institut National de la Santé et de la Recherche Médicale U1024, 46 Rue d'Ulm, 75005 Paris, France; and Centre d'Enseignement et de Recherches sur l'Environnement et la Société-Environmental Research and Teaching Institute, École Normale Supérieure, 24 Rue Lhomond, 75005 Paris, - - 2014
Abstract Competition is a major regulatory factor in population and community dynamics. Its effects can be either direct in interference competition or indirect in exploitative competition. The impact of exploitative competition on population dynamics has been extensively studied from empirical and theoretical points of view, but the consequences of interference ...
Ahmed Armin A Department of Critical Care Medicine, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, - - 2014
Over past few years, treatment of invasive candidiasis (IC) has evolved from targeted therapy to prophylaxis, pre-emptive and empirical therapy. Numerous predisposing factors for IC have been grouped together in various combinations to design risk prediction models. These models in general have shown good negative predictive value, but poor positive ...
Scrima Fabrizio F 1 University of Rennes - - 2014
Summary.-The goal was to compare three-factor and two-factor solutions and construct validity of the Adult Attachment in the Workplace (AAW) questionnaire. Participants were 660 volunteers from three countries (France, Italy, and Great Britain). The two-factor model of Neustadt, Chamorro-Premuzic, & Furnham (2006) and the three-factor theoretical model of Collins and ...
Lewnard Joseph A JA Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, Connecticut, United States of - - 2014
Cutaneous leishmaniasis (CL) is a vector-borne disease of increasing importance in northeastern Brazil. It is known that sandflies, which spread the causative parasites, have weather-dependent population dynamics. Routinely-gathered weather data may be useful for anticipating disease risk and planning interventions. We fit time series models using meteorological covariates to predict ...
Yu Yu Y Department of Social Medicine and Health Management, Public Health School, Central South University, Upper Mayuanlin Road 238, Changsha, 410008, Hunan, - - 2014
Evaluation and comparison of the factor structure of the Medical Outcomes Study Social Support Survey (MOS-SSS) using both confirmatory factor analysis (CFA) and exploratory factor analysis (EFA) with two samples of people living with HIV/AIDS in China. Secondary analyses were conducted with data from two comparable samples of 320 people ...
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