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Kahoul Riad R Novadiscovery SAS, 60 Avenue Rockefeller, 69008 Lyon, France UMR 5558, Laboratoire de Biométrie et Biologie Evolutive, CNRS, UCB Lyon 1 - Bât. Grégor Mendel, 43 bd du 11 novembre 1918, 69622 Villeurbanne cedex, France - - 2014
Healthcare authorities make difficult decisions about how to spend limited budgets for interventions that guarantee the best cost-efficacy ratio. We propose a novel approach for treatment decision-making, OMES-in French: Objectif thérapeutique Modèle Effet Seuil (in English: Therapeutic Objective-Threshold-Effect Model; TOTEM). This approach takes into consideration results from clinical trials, adjusted ...
Loehlin John C JC University of Texas at Austin, Austin, TX, - - 2014
Rotations of 1 to 12 factors were compared by Goldberg's "bass-ackward" method, with or without initially holding constant one or more principal components. Two sets of data were employed: ratings by 320 undergraduates using 435 personality-descriptive adjectives, and 512 Oregon community members' responses to 184 scales from 8 personality inventories. ...
de Keyser Catherine E CE Department of Epidemiology, Erasmus MC - University Medical Center Rotterdam, P.O. Box 2040, 3000 CA, Rotterdam, The Netherlands, - - 2014
When studying the causal effect of drug use in observational data, marginal structural modeling (MSM) can be used to adjust for time-dependent confounders that are affected by previous treatment. The objective of this study was to compare traditional Cox proportional hazard models (with and without time-dependent covariates) with MSM to ...
Griffin Tania L - - 2014
BackgroundThe implementation of a complex intervention is heavily influenced by individual context. Variation in implementation and tailoring of the intervention to the particular context will occur, even in a trial setting. It is recognised that in trials, evaluating the process of implementation of a complex intervention is important, yet process ...
Lynam Donald R DR Purdue - - 2014
The present paper argues that psychopathy is best understood as a collection of traits from the Five-Factor Model of personality (FFM). We demonstrate that specific FFM traits involved in psychopathy are well delineated; the same personality profile emerges across methods. We review research demonstrating that this FFM profile can be ...
Boeckmann Melanie M Leibniz Institute for Prevention Research and Epidemiology - BIPS, Department Prevention and Evaluation, Bremen, Germany; Center for Social Policy Research, University of Bremen, Germany. Electronic address: - - 2014
Climate change will likely have impacts on disease vector distribution. Posing a significant health threat in the 21st century, risk of tick-borne diseases may increase with higher annual mean temperatures and changes in precipitation. We modeled the current and future potential distribution of the Ixodes ricinus tick species in Europe. ...
Scarsoglio Stefania S Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Corso Duca degli Abruzzi 24, 10129, Torino, Italy, - - 2014
Atrial fibrillation (AF) is the most common arrhythmia affecting millions of people in the Western countries and, due to the widespread impact on the population and its medical relevance, is largely investigated in both clinical and bioengineering sciences. However, some important feedback mechanisms are still not clearly established. The present ...
Silverwood Richard J RJ Faculty of Epidemiology and Population Health, Centre for Statistical Methodology and Bloomsbury Centre for Genetic Epidemiology and Statistics, London School of Hygiene and Tropical Medicine, London, UK, Department of Epidemiology and Public Health, University College London, London, UK, MRC Integrative Epidemiology Unit and School of Social and Community Medicine, University of Bristol, Bristol, UK, Genetics, R & D, GlaxoSmithKline, Stevenage, UK, Division of Health Sciences, University of Warwick, Warwick, Coventry, UK, Center for Applied Genomics, Abramson Research Center, Children's Hospital of Philadelphia, Philadelphia, PA, USA and Institute of Cardiovascular Science, University College London, London, UK Faculty of Epidemiology and Population Health, Centre for Statistical Methodology and Bloomsbury Centre for Genetic Epidemiology and Statistics, London School of Hygiene and Tropical Medicine, London, UK, Department of Epidemiology and Public Health, University College London, London, UK, MRC Integrative Epidemiology Unit and School of Social and Community Medicine, University of Bristol, Bristol, UK, Genetics, R & D, GlaxoSmithKline, Stevenage, UK, Division of Health Sciences, University of Warwick, Warwick, Coventry, UK, Center for Applied Genomics, Abramson Research Center, Children's Hospital of Philadelphia, Philadelphia, PA, USA and Institute of Cardiovascular Science, University College London, London, UK Faculty of Epidemiology and Population Health, Centre for Statistical Methodology and Bloomsbury Centre for Genetic Epidemiology and Statistics, London School of Hygiene and Tropical Medicine, London, UK, Department of Epidemiology and Public Health, University College London, London, UK, MRC Integrative Epidemiology Unit and School of Social and Community Medicine, University of Bristol, Bristol, UK, Genetics, R & D, GlaxoSmithKline, Stevenage, UK, Division of Health Sciences, University of Warwick, Warwick, Coventry, UK, Center for Applied Genomics, Abramson Research Center, Children's Hospital of Philadelphia, Philadelphia, PA, USA and Institute of Cardiovascular Science, University College London, London, UK - - 2014
Mendelian randomization studies have so far restricted attention to linear associations relating the genetic instrument to the exposure, and the exposure to the outcome. In some cases, however, observational data suggest a non-linear association between exposure and outcome. For example, alcohol consumption is consistently reported as having a U-shaped association ...
Li Quefeng Q Department of Statistics, University of Wisconsin, Madison, Wisconsin, - - 2014
Recent advance in biotechnology and its wide applications have led to the generation of many high-dimensional gene expression data sets that can be used to address similar biological questions. Meta-analysis plays an important role in summarizing and synthesizing scientific evidence from multiple studies. When the dimensions of datasets are high, ...
Brittingham Margaret C - - 2014
Technological advances in hydraulic fracturing and horizontal drilling have led to the exploration and exploitation of shale oil and gas both nationally and internationally. Extensive development of shale resources has occurred within the United States over the past decade, yet full build out is not expected to occur for years. ...
Huang Ying Y Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N., Seattle WA, 98109, USA - - 2014
Biomarkers associated with heterogeneity in subject responses to treatment hold potential for treatment selection. In practice, the decision regarding whether to adopt a treatment-selection marker depends on the effect of using the marker on the rate of targeted disease and on the cost associated with treatment. We propose an expected ...
Chang C C CC Biomedical Electronics Translational Research Center and Biomimetic Systems Research Center, National Chiao Tung University, Taiwan. Department of Electronics Engineering and Institute of Electronics, National Chiao Tung University, - - 2014
Arterial blood pressure (ABP) is an important indicator of cardiovascular circulation and presents various intrinsic regulations. It has been found that the intrinsic characteristics of blood vessels can be assessed quantitatively by ABP analysis (called reflection wave analysis (RWA)), but conventional RWA is insufficient for assessment during non-stationary conditions, such ...
Halfwerk Wouter W Smithsonian Tropical Research Institute, Apartado 0843-03092 Balboa, Ancón, Republic of Panama - - 2014
Many sexual displays contain multiple components that are received through a variety of sensory modalities. Primary and secondary signal components can interact to induce novel receiver responses and become targets of sexual selection as complex signals. However, predators can also use these complex signals for prey assessment, which may limit ...
Sangachin Mahboobeh Ghesmaty MG Department of Industrial and Systems Engineering, University at Buffalo, Buffalo, NY, - - 2014
With the growing prevalence of obesity and the public health implications, it is critical to develop and evaluate potential interventions. One approach is to investigate the spread of positive health outcomes through a social network. We employ the ground concepts of spread maximization problem and adapt it to best reflect ...
Stuckey Erin M EM Swiss Tropical and Public Health Institute, Basel, Switzerland; University of Basel, Basel, - - 2014
Evaluating the effectiveness of malaria control interventions on the basis of their impact on transmission as well as impact on morbidity and mortality is becoming increasingly important as countries consider pre-elimination and elimination as well as disease control. Data on prevalence and transmission are traditionally obtained through resource-intensive epidemiological and ...
Pencina Karol M KM Statistics and Consulting Unit, Department of Mathematics and Statistics, Boston University, Boston, 02215, MA, - - 2014
The net reclassification improvement (NRI) has become a popular measure of incremental usefulness of markers added to risk prediction models. However, the expected magnitude of the three-category NRI is not well understood, leading researchers to rely on statistical significance. In this paper, we describe a slight modification to the original ...
Schmauss Daniel D Department of Cardiac Surgery, Ludwig-Maximilians-Universität München, Munich, Germany Department of Plastic Surgery and Hand Surgery, Klinikum rechts der Isar, Technische Universität München, Munich, - - 2014
In individual cases, routine preoperative imaging might not be sufficient for optimal planning of cardiovascular procedures. Three-dimensional printing (3D), a widely used technique to build life-like replicas of anatomical structures that has proven value in different medical disciplines, might overcome these shortcomings. However, data on 3D printing in cardiovascular medicine ...
Van Calster Ben B KU Leuven, Department of Development and Regeneration, Leuven, Belgium (BVC)Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY (AJV) - - 2014
Decision-analytic measures to assess clinical utility of prediction models and diagnostic tests incorporate the relative clinical consequences of true and false positives without the need for external information such as monetary costs. Net Benefit is a commonly used metric that weights the relative consequences in terms of the risk threshold ...
Walsh Colin C Department of Biomedical Informatics, Columbia University, United States; Department of Medicine, Columbia University, United States. Electronic address: - - 2014
Hospital readmission risk prediction remains a motivated area of investigation and operations in light of the hospital readmissions reduction program through CMS. Multiple models of risk have been reported with variable discriminatory performances, and it remains unclear how design factors affect performance. To study the effects of varying three factors ...
Pruvot M M Faculty of Veterinary Medicine, University of Calgary, 3330 Hospital Drive NW, Calgary, AB, Canada T2N 4N1. Electronic address: - - 2014
In Southwest Alberta, beef cattle and wild elk (Cervus elaphus) have similar habitat preferences. Understanding their inter-species contact structure is important for assessing the risk of pathogen transmission between them. These spatio-temporal patterns of interactions are shaped, in part, by range management and environmental factors affecting elk distribution. In this ...
Thomson Jordan A JA Department of Biological Sciences, School of Environment, Arts and Society, Florida International University, 3000 NE 151st St., North Miami, FL, 33181, - - 2014
Extreme climatic events can trigger abrupt and often lasting change in ecosystems via the reduction or elimination of foundation (i.e., habitat-forming) species. However, while the frequency/intensity of extreme events is predicted to increase under climate change, the impact of these events on many foundation species and the ecosystems they support ...
de Vecchi A A Division of Imaging Sciences and Biomedical Engineering, King's College London, St. Thomas' Hospital, London, SE1 7EH, - - 2014
Computer modeling of the heart has emerged over the past decade as a powerful technique to explore the cardiovascular pathophysiology and inform clinical diagnosis. The current state-of-the-art in biophysical modelling requires a wealth of, potentially invasive, clinical data for the parametrisation and validation of the models, a process that is ...
Wolf Svenja A SA a German Sport University Cologne , Cologne , - - 2014
Abstract Athletes' precompetitive appraisal determines which emotion they experience with regard to an upcoming competition. Such precompetitive emotions have powerful and potentially destructive consequences for performance. To control and optimise these consequences, it is important to examine precompetitive appraisal. Currently, such efforts are hampered by the lack of a valid ...
Holmes Glen G School of Geography, Planning and Environmental Management, The University of Queensland, Brisbane, QLD 4072, Australia. Electronic address: - - 2014
In November 2012, the Australian Pesticide and Veterinary Medicines Authority (APVMA) concluded a 12year review of the PSII herbicide diuron. One of the primary concerns raised during the review was the potential impact on aquatic ecosystems, particularly in the catchments draining to the Great Barrier Reef. The environmental risk assessment ...
Tang Philip Chiu-Tsun PC Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong, - - 2014
Resveratrol (3,5,4'-trihydroxy-trans-stilbene) is a natural polyphenolic compound that exists in Polygonum cuspidatum, grapes, peanuts and berries, as well as their manufactured products, especially red wine. Resveratrol is a pharmacologically active compound that interacts with multiple targets in a variety of cardiovascular disease models to exert protective effects or induce a ...
Wyss Richard - - 2014
The covariate-balancing propensity score (CBPS) extends logistic regression to simultaneously optimize covariate balance and treatment prediction. Although the CBPS has been shown to perform well in certain settings, its performance has not been evaluated in settings specific to pharmacoepidemiology and large database research. In this study, we use both simulations ...
Fowler J Christopher JC The Menninger Clinic, Houston, TX 77035, USA; Baylor College of Medicine, Houston, TX 77030, USA. Electronic address: - - 2014
The Difficulties in Emotion Regulation Scale (DERS: Gratz and Roemer, 2004) is a measure of emotion-regulation capacities with good construct validity, test-retest reliability and internal consistency. Factor analytic studies have produced mixed results, with the majority of studies supporting the original 6-factor model while several studies advance alternative 5-factor models, ...
Sharenkov Alexey A Julius Wolff Institute, Charité - Universitätsmedizin Berlin, Germany; Center for Sports Medicine and Sport Sciences Berlin, Germany. Electronic address: - - 2014
The division of gait into cycles is crucial for identifying deficits in locomotion, particularly to monitor disease progression or rehabilitative recovery. Initial contact (IC) events are often used to separate movement into repetitive cycles yet automatic methods for IC identification in pathological gait are limited in both number and capacity. ...
Vásquez G A GA Division of Mechatronics, Biostatistics and Sensors (MeBioS), Department of Biosystems, KU Leuven, Willem de Croylaan 42, B-3001 Leuven, - - 2014
Quantitative Microbiological Risk Assessment (QMRA) is a structured methodology used to assess the risk involved by ingestion of a pathogen. It applies mathematical models combined with an accurate exploitation of data sets, represented by distributions and - in the case of two-dimensional Monte Carlo simulations - their hyperparameters. This research ...
Arjona A A Thomson Reuters, Barcelona, Spain. - - 2014
As the pharmaceutical industry strives to meet the ever-increasing complexity of drug development, new technology in clinical trials has become a beacon of hope. With big data comes the promise of accelerated patient recruitment, real-time monitoring of clinical trials, bioinformatics empowerment of quicker phase progression, and the overwhelming benefits of ...
Akhtar Syed S 1 Department of Management, City University of Hong - - 2014
Summary.-This study assessed the factor structure of the Work Regulatory Focus Scale, which includes work-related prevention and promotion as dimensions of regulatory focus. To examine the concurrent validity, these dimensions were correlated with the prevention and promotion subscales of the Chronic Regulatory Focus Questionnaire. Using computer-assisted telephone interviews, data were ...
Veddegjærde Kari-Elise Frøystad KE Department of Clinical Science, University of Bergen, Bergen, Norway; Division of Mental Health, Norwegian Institute of Public Health, Bergen, Norway; Department of Medicine, Haraldsplass Deaconess Hospital, Bergen, Norway. Electronic address: - - 2014
The Whiteley Index (WI) is a widely used screening instrument for health anxiety/hypochondriasis. Several studies have previously explored the psychometric properties of the WI, but with mixed findings concerning both item composition and factor structure. The main aim of the current study was to examine different factor structures as identified ...
Ingle Matthew E ME Cedarville University, 251 N. Main St., Cedarville, OH 45314, United States ; Loma Linda University, 11234 Anderson St., Loma Linda, CA 92354, United - - 2014
Raccoon roundworm is a leading cause of a neurological disease known as larva migrans encephalopathy in vertebrates. We determined that roundworm prevalence is significantly lower in Beavercreek Township than other townships surveyed, and that mean patch size and proportion of landscape modified by urbanization or by agriculture are good predictors ...
Chiang Hsiu-Sen HS Department of Information Management, National Taichung University of Science & Technology, 129, Sec. 3, Sanmin Road, Taichung City 404, TAIWAN; Phone: (886)921-730662; Email: - - 2014
Changes in the normal rhythm of a human heart may result in different cardiac arrhythmias, which may be immediately fatal or cause irreparable damage to the heart sustained over long periods of time. Therefore, the ability to automatically identify arrhythmias from ECG recordings is important for clinical diagnosis and treatment. ...
Tanantong Tanatorn - - 2014
Five well-known arrhythmia classification algorithms were compared in this paper based on the recommendations in AAMI standard. They are C4.5, k-Nearest Neighbor, Multilayer Perceptron, PART, and Support Vector Machine, respectively, with inputs related to heartbeat intervals and ECG morphological features. They were evaluated on three independent datasets, including the MIT-BIH ...
Head David A DA School of Computing, University of Leeds, Leeds, United - - 2014
Dental caries or tooth decay is a prevalent global disease whose causative agent is the oral biofilm known as plaque. According to the ecological plaque hypothesis, this biofilm becomes pathogenic when external challenges drive it towards a state with a high proportion of acid-producing bacteria. Determining which factors control biofilm ...
Guo Shijing S Centre for Health Informatics, City University London, - - 2014
Missed, wrong or delayed diagnosis has a direct effect on patient safety. Diagnostic errors have been discussed at length, however it still lacks a systematic approach. This study proposed a more systematic way of studying diagnostic errors by using a causal loop diagram. A systematic review was used to find ...
Stumpf Michael P H MP Centre for Integrative Systems Biology and Bioinformatics Department of Life Sciences, Sir Ernst Chain Building, Imperial College London, London, SW7 2AZ - - 2014
Mathematical models have been central to ecology for nearly a century. Simple models of population dynamics have allowed us to understand fundamental aspects underlying the dynamics and stability of ecological systems. What has remained a challenge, however, is to meaningfully interpret experimental or observational data in light of mathematical models. ...
Louis Elan D ED GH Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA ; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY, USA ; Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA ; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, - - 2014
Essential tremor (ET) is often reported to be among the most prevalent movement disorders, yet the precise number of cases in the USA is not known. The goal of the current analyses was to use published data from epidemiological studies to derive an estimate of the number of people currently ...
Wang Hanxi H School of Environment, Northeast Normal University, Changchun 130117, China. - - 2014
This paper evaluated the oil spillage risk in the waters near the island of Changxing in Dalian (China) based on the established risk assessment index. Four wind regimes (windless, northerly wind, westerly wind and southerly wind) were selected as weather conditions for the dynamic prediction of oil drift. If an ...
Sah Pratha P Population Biology Laboratory, Biology Division, Indian Institute of Science Education and Research-Pune, Pashan, Pune, Maharashtra, - - 2014
Stabilizing the dynamics of complex, non-linear systems is a major concern across several scientific disciplines including ecology and conservation biology. Unfortunately, most methods proposed to reduce the fluctuations in chaotic systems are not applicable to real, biological populations. This is because such methods typically require detailed knowledge of system specific ...
Cobolet Guy - - 2014
This session focuses on the Fabrica (1543). Karger Publishers of Basel are producing a new English translation, by Daniel Garrison and Malcom Hast, to coincide with the quincentenary while Vivian Nutton's scholarly analysis of a newly discovered second edition indicates that the annotations are of Vesalius himself.
Nataletti Pietro P Department of Occupational Hygiene, National Workers' Compensation Authority (INAIL), Rome, Italy. - - 2014
This article presents the new Italian database of physical agents, which is available at http://www.portaleagentifisici.it. It supports in risk assessment employers who have to comply with Italy's Legislative Decree 81/2008 (transposing into law European Union Directives 2003/10/EC, 2002/44/EC, 2004/40/EC and 2006/25/EC). The database currently contains measurements and declared European Community ...
Jiaxing Zhan Z School of Aerospace, Mechanical & Manufacturing Engineering, RMIT University, Melbourne, Australia. - - 2014
A large number of independent and interacting factors affect seating comfort such as seat shape, stability, lumbar support and seat height. Although many subjective comfort studies have been conducted, few of them considered seating comfort from its subassembly level. This paper analyzed the automotive seat cushion designed with geared four-bar ...
Pointin Fabien F Centre for Ocean Life, National Institute of Aquatic Resources (DTU-Aqua), Technical University of Denmark, Charlottenlund, - - 2014
We provide the strongest evidence to date supporting the existence of two independent blue whiting (Micromesistius poutassou (Risso, 1827)) populations in the North Atlantic. In spite of extensive data collected in conjunction with the fishery, the population structure of blue whiting is poorly understood. On one hand, genetic, morphometric, otolith ...
Liu Hai-Ning HN College of Resources and Environment Science, Hunan Normal University, Changsha, - - 2014
Hemorrhagic fever with renal syndrome (HFRS), a rodent-borne infectious disease, is one of the most serious public health threats in China. Increasing our understanding of the spatial and temporal patterns of HFRS infections could guide local prevention and control strategies. We employed statistical models to analyze HFRS case data together ...
De Beurs Derek Paul DP http://orcid.org/0000-0002-0166-6897 Faculty of Psychology and Education, Department of Clinical Psychology, VU University Amsterdam, Amsterdam, Netherlands. - - 2014
The Internet is used increasingly for both suicide research and prevention. To optimize online assessment of suicidal patients, there is a need for short, good-quality tools to assess elevated risk of future suicidal behavior. Computer adaptive testing (CAT) can be used to reduce response burden and improve accuracy, and make ...
Trayanova Natalia A NA Institute for Computational Medicine, Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, - - 2013
Modern cardiovascular research has increasingly recognized that heart models and simulation can help interpret an array of experimental data and dissect important mechanisms and interrelationships, with developments rooted in the iterative interaction between modeling and experimentation. This article reviews the progress made in simulating cardiac electrical behavior at the level ...
Javadi Mehrdad - - 2013
Abstract In this paper, the supervised classification of the electrocardiogram (ECG) beats based on the fusion of several intelligent learning machines is described. For classification of ECG heartbeats, first, the QRS complexes are delineated by an efficient algorithm so as to identify the fiducial and J-locations of each complex. For ...
Masiuk Sergii Volodymyrovych - - 2013
Objective. To estimate the influence of Berkson errors in exposure doses on the results of risk analysis within example of radiation epidemiological studies of the thyroid cancer prevalence. Materials and methods. The impact of Berkson errors of the thyroid doses in a dose-response analysis is studied by the method of ...
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