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Arsanjani Reza R Departments of Imaging and Medicine, and Cedars-Sinai Heart Institute, Cedars-Sinai Medical Center, 8700 Beverly Blvd, Taper A238, Los Angeles, CA, 90048, USA, - - 2014
We aimed to investigate if early revascularization in patients with suspected coronary artery disease can be effectively predicted by integrating clinical data and quantitative image features derived from perfusion SPECT (MPS) by machine learning (ML) approach. 713 rest (201)Thallium/stress (99m)Technetium MPS studies with correlating invasive angiography with 372 revascularization events ...
Kim Jungsil J Department of Mechanical Engineering and Materials Science, Washington University, One Brookings Dr., CB 1185, St. Louis, MO, 63130, - - 2014
Models of vascular mechanics are necessary to predict the response of an artery under a variety of loads, for complex geometries, and in pathological adaptation. Classic constitutive models for arteries are phenomenological and the fitted parameters are not associated with physical components of the wall. Recently, microstructurally-linked models have been ...
Cyron C J CJ Department of Biomedical Engineering Yale University, New Haven, CT, 06520, - - 2014
Vascular mechanics has been studied in depth since the early 1970s mainly following classical concepts from continuum mechanics. Yet, an important distinction of blood vessels, in contrast to typical engineering materials, is the continuous degradation and deposition of material in these living tissues. In this paper we examine mechanical consequences ...
Cheng Zheng - - 2014
To explore the feasibility of a new method of achieving a permanent A-V block animal model. 16 beagles were randomly divided into two groups based on the method of their pre-implanted biventricular pacemakers. (1) In the first group (8 beagles), the A-V block model was achieved by ablating his-bundle potential ...
Yoder Karmen K KK Radiology & Imaging Sciences, Indiana University School of Medicine, Indianapolis IN; Center for Neuroimaging, Indiana University School of Medicine, Indianapolis IN; Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN. Electronic address: - - 2014
[(11)C]PBR28 is a high-affinity ligand for the Translocator Protein 18kDa (TSPO), which is considered to be a marker for microglial activation. Volume of distribution (VT) estimated with an arterial plasma input function is the gold standard for quantitation of [(11)C]PBR28 binding. However, arterial sampling is impractical at many PET sites ...
Azimi P P Department of Neurosurgery, Shahid Beheshti University of Medical Sciences, Tehran, Iran - - - 2014
A lack of consensus exists regarding indications for surgery for lumbar spinal canal stenosis (LSCS). Hence, the aim of this study is to develop an artificial neural network (ANN) model that is designed to accurately select patients for surgery or non--surgical options and to compare such with the traditional clinical ...
Park Juneyoung J Department of Civil, Environmental and Construction Engineering, University of Central Florida, Orlando, Florida 32816-2450, USA. Electronic address: - - 2014
Although many researchers have estimated crash modification factors (CMFs) for specific treatments (or countermeasures), there is a lack of studies that explored the heterogeneous effects of roadway characteristics on crash frequency among treated sites. Generally, the CMF estimated by before-after studies represents overall safety effects of the treatment in a ...
Buschang Peter H PH a Regent's Professor and Director of Orthodontic Research, Department of Orthodontics, Texas A&M University Baylor College of Dentistry, Dallas, - - 2014
Objective: To compare three-dimensional (3D) ClinCheck™ models with the subjects' actual 3D posttreatment models using the American Board of Orthodontics Objective Grading System (OGS). Materials and Methods: This prospective, within-subject study included 27 consecutive cases treated with aligner therapy. The posttreatment plaster models taken immediately after treatment were scanned and ...
Vardi Moshe M Harvard Clinical Research Institute, 930 Commonwealth Ave, Boston, MA 02215 USA. Vardi.moshe@gmail.com or - - 2014
Primary patency (PP) in trials assessing superficial femoral artery (SFA) stenting is defined as a combination of vessel patency assessed by duplex ultrasound (DUS) at the 12-month follow-up exam and freedom from revascularization of the index vessel through 12 months of follow-up. Loss of PP is thus more likely to ...
McCann Thomas E TE Department of Diagnostic Radiology, Yale University School of Medicine, 333 Cedar Street, PO Box 208042, New Haven, CT 06520, - - 2014
Peripheral arterial disease (PAD) is an important manifestation of atherosclerosis, with an estimated age-adjusted prevalence of approximately 13% in people older than 50 years. Noninvasive vascular laboratory physiologic studies are indispensable tools in the initial evaluation and workup and postintervention follow-up. In this review, we describe a practical approach to the ...
Guala Andrea A DIATI, Politecnico di Torino, Turin, Italy, - - 2014
A modeling approach integrated with a novel subject-specific characterization is here proposed for the assessment of hemodynamic values of the arterial tree. A 1D model is adopted to characterize large-to-medium arteries, while the left ventricle, aortic valve and distal micro-circulation sectors are described by lumped submodels. A new velocity profile ...
Blanco Pablo - - 2014
Simulation platforms are increasingly becoming complementary tools for cutting-edge cardiovascular research. The interplay among structural properties of arterial wall, morphometry, anatomy, wave propagation phenomena and, ultimately, cardiovascular diseases continues to be poorly understood. Accurate models are powerful tools to shed light on these open problems. We developed an anatomically detailed ...
Oyama Kenichi K Department of Neurological Surgery, The Ohio State University Wexner Medical Center, 410 West 10th Avenue, Columbus, OH, 43210, USA, - - 2014
Mastery of the expanded endoscopic endonasal approach (EEA) requires anatomical knowledge and surgical skills; the learning curve for this technique is steep. To a great degree, these skills can be gained by cadaveric dissections; however, ethical, religious, and legal considerations may interfere with this paradigm in different regions of the ...
Cherry Kevin M KM Imaging Biomarkers and Computer-Aided Diagnosis Laboratory, Radiology and Imaging Sciences, National Institutes of Health Clinical Center, Building 10 Room 1C224D MSC 1182, Bethesda, MD 20892-1182, United - - 2014
Given the potential importance of marginal artery localization in automated registration in computed tomography colonography (CTC), we have devised a semi-automated method of marginal vessel detection employing sequential Monte Carlo tracking (also known as particle filtering tracking) by multiple cue fusion based on intensity, vesselness, organ detection, and minimum spanning ...
Naik Naren - - 2014
The dynamic reconstruction problem in tomographic imaging is encountered in several applications, such as species determination, the study of blood flow through arteries/veins, motion compensation in medical imaging, and process tomography. The reconstruction method of choice is the Kalman filter and its variants, which, however, are faced by issues of ...
Kwon Soon-Sung SS Department of Mechanical and Biomedical Engineering, Kangwon National University, 192-1, Hyoja 2-dong, Chuncheon, Kangwon, 200-701, Republic of - - 2014
The fractional flow reserve (FFR) is a widely used clinical index to evaluate the functional severity of coronary stenosis. A computer simulation method based on patients' computed tomography (CT) data is a plausible non-invasive approach for computing the FFR. This method can provide a detailed solution for the stenosed coronary ...
Karanasos Antonios A Department of Interventional Cardiology, Thoraxcentre, BA-585, Erasmus University Medical Centre, Gravendijkwal 230, 3015 CE Rotterdam, The - - 2014
In coronary bifurcations assessment, evaluation of side-branch (SB) ostia by an optical coherence tomography (OCT) pullback performed in the main branch (MB) could speed up lesion evaluation and minimize contrast volume. Dedicated software that reconstructs the cross-sections perpendicular to the SB centreline could improve this assessment. We aimed to validate ...
Ovcharenko E A EA Research Institute for Complex Issues of Cardiovascular Diseases under the Siberian Branch of the Russian Academy of Medical Sciences, Kemerovo, Russian - - 2014
The development of computer-based 3D models of the aortic root is one of the most important problems in constructing the prostheses for transcatheter aortic valve implantation. In the current study, we analyzed data from 117 patients with and without aortic valve disease and computed tomography data from 20 patients without ...
Yang Ming - - 2014
Windstorms are the major natural hazard affecting European forests, causing tree damage and timber losses. Modelling tree anchorage mechanisms has progressed with advances in plant architectural modelling, but it is still limited in terms of estimation of anchorage strength. This paper aims to provide a new model for root anchorage, ...
Liu Dong - - 2014
Aspheric non-null testing, as an alternative to the traditional null testing, achieves more flexible measurements. However, figure-error reconstruction in non-null tests has always been difficult due to the presence of retrace error. A novel method with reverse optimization is proposed for aspheric figure-error reconstruction in a non-null interferometer. It is ...
Cai Junfeng J Department of Cardiosurgery, Ruijin Hospital, Shanghai, - - 2014
 Geometric features of the aortic valve play an important role in many applications, such as the clinical diagnostics, shape modeling and image-guided cardiac interventions, especially for the transcatheter aortic valve implantation (TAVI) procedure. However, few works have been reported on the topic of aortic valve segmentation from transesophageal echocardiography (TEE) ...
Cheng Z Z Department of Chemical Engineering, Imperial College London, South Kensington Campus, London SW7 2AZ, - - 2014
Aortic dissection is a life-threatening process in which the weakened wall develops a tear, causing separation of wall layers. The dissected layers separate the original true aortic lumen and a newly created false lumen. If untreated, the condition can be fatal. Flow rate in the false lumen is a key ...
Nanda Aditi A Department of Prosthodontics, Maulana Azad Institute of Dental Sciences, Mamc Campus, New Delhi, - - 2014
Decimated dentitions may require raising the vertical dimension in some conditions while performing a full mouth rehabilitation treatment. Increase in a vertical dimension should be diagnosed by reversible methods prior to performing any irreversible methods for a minimum time period. Reversible methods like splints and overlay dentures are often used ...
Biglino Giovanni G * These authors contributed equally to this - - 2014
Reliability of computational models for cardiovascular investigations strongly depends on their validation against physical data. This study aims to experimentally validate a computational model of complex congenital heart disease (i.e., surgically palliated hypoplastic left heart syndrome with aortic coarctation) thus demonstrating that hemodynamic information can be reliably extrapolated from the ...
Vismara Riccardo R 3 For Cardio Lab, Università di Milano - Politecnico di Milano, Milan - - - 2014
Cusp extension technique (CET) is a reparative surgical procedure for restoring aortic valve function by suturing patches to the compromised native leaflets. Its outcomes are strongly dependent on the ability of the surgeon. We proposed and tested a novel approach on an in vitro model, aimed at standardizing and simplifying ...
Andrinopoulou Eleni-Rosalina ER Department of Biostatistics, Erasmus MC, Rotterdam, The Netherlands; Department of Cardiothoracic Surgery, Erasmus MC, Rotterdam, The - - 2014
Aortic gradient and aortic regurgitation are echocardiographic markers of aortic valve function. Both are biomarkers repeatedly measured in patients with valve abnormalities, and thus, it is expected that they are biologically interrelated. Loss of follow-up could be caused by multiple reasons, including valve progression related, such as an intervention or ...
Capodanno Davide D Division of Cardiology, Ferrarotto Hospital, University of Catania, Catania, Italy; ETNA Foundation, Catania, Italy. Electronic address: - - 2014
Risk stratification tools used in patients with severe aortic stenosis have been mostly derived from surgical series. Although specific predictors of early mortality with transcatheter aortic valve replacement (TAVR) have been identified, the prognostic impact of their combination is unexplored. We sought to develop a simple score, using preprocedural variables, ...
Jassar Arminder S AS Gorman Cardiovascular Research Group, University of Pennsylvania, Glenolden, Pennsylvania; Department of Surgery, University of Pennsylvania, Philadelphia, - - 2014
Surgical techniques for aortic valve (AV) repair are directed toward restoring normal structural relationships in the aortic root and rely on detailed assessment of root and valve anatomy. Noninvasive three-dimensional (3D) imaging and modeling may assist in patient selection and operative planning. Transesophageal real-time 3D echocardiographic images of 5 patients ...
Rolls A E AE Division of Surgery and Cancer Imperial College London, London, UK - - - 2014
Endovascular intervention has revolutionized the treatment of aortic disease, extending the cohort of patients eligible for repair. Accurate planning for endovascular aortic repair is essential. Recent advances in modern software have demonstrated potential for improving outcomes and enhancing the decision making process beyond 3D measurements and intraoperative navigation techniques. With ...
Pal Siladitya S Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, United - - 2014
Aortic dissection (AoD) is a common condition that often leads to life-threatening cardiovascular emergency. From a biomechanics viewpoint, AoD involves failure of load-bearing microstructural components of the aortic wall, mainly elastin and collagen fibers. Delamination strength of the aortic wall depends on the load-bearing capacity and local micro-architecture of these ...
Kamangar Sarfaraz S Department of Mechanical Engineering, University of Malaya, 50603 Kuala Lumpur, - - 2014
The present study deals with the functional severity of a coronary artery stenosis assessed by the fractional flow reserve (FFR). The effects of different geometrical shapes of lesion on the diagnostic parameters are unknown. In this study, 3D computational simulation of blood flow in three different geometrical shapes of stenosis ...
Veljković Dejan Ž DŽ Research and Development Center for Bioengineering BioIRC, Kragujevac, - - 2014
Most of hyperelastic models for the constitutive modeling of the typical mechanical behaviour of the arterial wall tissue in literature are based on the test data from different animals and arteries. This paper is concerned with the material parameter identification of several phenomenological hyperelastic models by fitting the data from ...
Ji Shuang S Division of Biostatistics, University of Texas Health Science - - 2014
Dependent censoring occurs in many biomedical studies and poses considerable methodological challenges for survival analysis. In this work, we develop a new approach for analyzing dependently censored data by adopting quantile regression models. We formulate covariate effects on the quantiles of the marginal distribution of the event time of interest. ...
Wang Shou-Sen SS Department of Neurosurgery, Fuzhou General Hospital, Fujian Medical University 156 Xihuanbei Road, Fuzhou 350025, - - 2014
Neurosurgery in areas with restricted space and complicated anatomy can be greatly aided by the virtual reality (VR) technique. The clivus represents one of such challenging surgical areas, but its VR has not been established. The present study aimed to document a VR model of clival anatomy that may be ...
Sun Guoli - - 2014
One of the most common goals of hierarchical clustering is finding those branches of a tree that form quantifiably distinct data subtypes. Achieving this goal in a statistically meaningful way requires (a) a measure of distinctness of a branch and (b) a test to determine the significance of the observed ...
Swee Joshua K Y - - 2014
Transcatheter aortic valve implantation (TAVI) is becoming a standard treatment for non-operable and high-risk patients with symptomatic severe aortic valve stenosis. As there is no direct view or access to the affected anatomy, comprehensive preoperative planning is crucial for a successful outcome, with the most important decisions made during planning ...
Schneider Matthias - - 2014
This paper describes a new approach for the reconstruction of complete 3-D arterial trees from partially incomplete image data. We utilize a physiologically motivated simulation framework to iteratively generate artificial, yet physiologically meaningful, vasculatures for the correction of vascular connectivity. The generative approach is guided by a simplified angiogenesis model, ...
Chen Chia-Yuan - - 2013
The pathology of the human abdominal aortic aneurysm (AAA) and its relationship to the later complication of intraluminal thrombus (ILT) formation remains unclear. The hemodynamics in the diseased abdominal aorta is hypothesized to be a key contributor to the formation and growth of ILT. The objective of this investigation is ...
Casciaro Mariano E - - 2013
Diagnosis and management of thoracic aorta (TA) disease demand the assessment of accurate quantitative information of the aortic anatomy. We investigated the principal modes of variation in aortic 3-dimensional geometry paying particular attention to the curvilinear portion. Images were obtained from extended noncontrast multislice computed tomography scans, originally intended for ...
Alimohammadi Mona - - 2013
Aortic dissection has high morbidity and mortality rates and guidelines regarding surgical intervention are not clearly defined. The treatment of aortic dissection varies with each patient and detailed knowledge of haemodynamic and mechanical forces would be advantageous in the process of choosing a course of treatment. In this study, a ...
Bollache E - - 2013
The aorta plays a major role in the cardiovascular system and its function and structure are primarily affected by aging, eating habits, life style and other cardiovascular risk factors, inducing increased stiffness which is associated with cardiovascular and cerebral morbi-mortality. Our objective was to develop and validate a robust subject-specific ...
Patil Mukesh D - - 2013
Recently fractional-order (FO) differential equations are widely used in the areas of modeling and control. They are multivalued in nature hence their stability is defined using Riemann surfaces. The stability analysis of FO linear systems using the technique of Root Locus is the main focus of this paper. Procedure to ...
Fresiello Libera L Section of Rome, Institute of Clinical Physiology, National Research Council, Rome - Italy and Nale?cz Institute of Biocybernetics and Biomedical Engineering, Polish Academy of Sciences, Warsaw - - - 2013
Introduction: The aim of this study was to investigate the effects of the intra aortic balloon pump (IABP) and of aortic compliance on left ventricular performance, including the effects of baroreflex control.
Methods: The study was conducted using a hybrid cardiovascular simulator, including a computational cardiovascular sub-model, a hydraulic sub-model of ...
Soslow Jonathan H - - 2013
Diagnosing coarctation of the aorta (CoA) in the presence of a patent ductus arteriosus (PDA) may require observation until PDA closure. The aim of this study was to create a model incorporating previously published indices to estimate the probability of neonatal CoA in the presence of a PDA. A retrospective "investigation" ...
Garcia Julio - - 2013
Valve effective orifice area EOA and transvalvular mean pressure gradient (MPG) are the most frequently used parameters to assess aortic stenosis (AS) severity. However, MPG measured by cardiovascular magnetic resonance (CMR) may differ from the one measured by transthoracic Doppler-echocardiography (TTE). The objectives of this study were: 1) to identify ...
Hahn Rebecca T - - 2013
Studies evaluating three-dimensional echocardiographic (3DE) annular sizing for balloon-expandable transcatheter aortic valve replacement (TAVR) are limited. In this study, a retrospective analysis of transesophageal echocardiographic images was performed to assess the feasibility of multiplanar measurements of annular dimensions by the novel off-label use of commercially available 3DE software and correlate ...
Sturla Francesco - - 2013
Numerical modeling can provide detailed and quantitative information on aortic root (AR) biomechanics, improving the understanding of AR complex pathophysiology and supporting the development of more effective clinical treatments. From this standpoint, fluid-structure interaction (FSI) models are currently the most exhaustive and potentially realistic computational tools. However, AR FSI modeling ...
Schlicht M S MS Vascular Mechanics Laboratory, Department of Mechanical Engineering, University of Michigan, Ann Arbor, MI, USA. Electronic address: - - 2013
This study was performed to determine the feasibility of measuring the elastic properties of the arterial wall in vivo. To prove this concept, elastic parameters were calculated from an aortic model of elastic behavior similar to a human aorta using computed tomography angiography (CTA) images. We first constructed an aortic ...
Dangi Siddharth - - 2013
Closed-loop decoder adaptation (CLDA) is an emerging paradigm for improving or maintaining the online performance of brain-machine interfaces (BMIs). Here, we present Likelihood Gradient Ascent (LGA), a novel CLDA algorithm for a Kalman filter (KF) decoder that uses stochastic, gradient-based corrections to update KF parameters during closed-loop BMI operation. LGA's ...
Wang Juan - - 2013
Rooted phylogenetic trees constructed from different datasets (e.g. from different genes) are often conflicting with one another, i.e. they cannot be integrated into a single phylogenetic tree. Phylogenetic networks have become an important tool in molecular evolution, and rooted phylogenetic networks are able to represent conflicting rooted phylogenetic trees. Hence, ...
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