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Yan Xiao-Yong XY School of Systems Science, Beijing Normal University, Beijing 100875, People's Republic of China Department of Transportation Engineering, Shijiazhuang Tiedao University, Shijiazhuang 050043, People's Republic of - - 2014
Despite the long history of modelling human mobility, we continue to lack a highly accurate approach with low data requirements for predicting mobility patterns in cities. Here, we present a population-weighted opportunities model without any adjustable parameters to capture the underlying driving force accounting for human mobility patterns at the ...
Schofield Lynne Steuerle LS Department of Mathematics and Statistics, Swarthmore College, 500 College Avenue, Swarthmore, PA, 19081, USA, - - 2014
Plausible values (PVs) are a standard multiple imputation tool for analysis of large education survey data, which measures latent proficiency variables. When latent proficiency is the dependent variable, we reconsider the standard institutionally generated PV methodology and find it applies with greater generality than shown previously. When latent proficiency is ...
Jiang Lingling - - 2014
Pharmacophore modeling incorporates geometric and chemical features of known inhibitors and/or targeted binding sites to rationally identify and design new drug leads. In this study, we have encoded a three-dimensional pharmacophore matching similarity (FMS) scoring function into the structure-based design program DOCK. Validation and characterization of the method are presented ...
Burns Randal R Institute for Data-Intensive Science and Engineering, The Johns Hopkins University, Baltimore, MD 21218, USA; Department of Computer Science, The Johns Hopkins University, Baltimore, MD 21218, USA. Electronic address: - - 2014
The analysis of data requires computation: originally by hand and more recently by computers. Different models of computing are designed and optimized for different kinds of data. In data-intensive science, the scale and complexity of data exceeds the comfort zone of local data stores on scientific workstations. Thus, cloud computing ...
Warnell I I Department of Anaesthesia, Royal Victoria Infirmary, Newcastle upon Tyne NHS Foundation Trust, Queen Victoria Road, Newcastle upon Tyne NE1 4LP, UK - - 2014
Summary Predicting risk of perioperative mortality after oesophagectomy for cancer may assist patients to make treatment choices and allow balanced comparison of providers. The aim of this systematic review of multivariate prediction models is to report their performance in new patients, and compare study methods against current recommendations. We used ...
Wang Kenneth T - - 2014
The Cross-Cultural Loss Scale (CCLS), a measure of loss associated with crossing national boundaries, was developed across 2 samples of international students. With Sample 1 (N = 262), exploratory factor analyses were used to select the 14 CCLS items and to determine 3 factors: Belonging-Competency (α = .87), National Privileges ...
Tseng Yi-Ju - - 2014
A description of patient conditions should consist of the changes in and combination of clinical measures. Traditional data-processing method and classification algorithms might cause clinical information to disappear and reduce prediction performance. To improve the accuracy of clinical-outcome prediction by using multiple measurements, a new multiple-time-series data-processing algorithm with period ...
Sun Huiyong H Institute of Functional Nano and Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices and Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou, Jiangsu 215123, P. R. China. tingjunhou@zju.edu.cn - - 2014
With the rapid development of computational techniques and hardware, more rigorous and precise theoretical models have been used to predict the binding affinities of a large number of small molecules to biomolecules. By employing continuum solvation models, the MM/GBSA and MM/PBSA methodologies achieve a good balance between low computational cost ...
Rørbech Jakob Thaysen - - 2014
Resources have received significant attention in recent years resulting in development of a wide range of resource depletion indicators within Life Cycle Assessment (LCA). Understanding the differences in assessment principles used to derive these indicators and the effects on the impact assessment results is critical for indicator selection and interpretation ...
Dziak John J JJ The Methodology Center, Pennsylvania State University, University Park, PA, 16802, - - 2014
Ordinal responses are very common in longitudinal data collected from substance abuse research or other behavioral research. This study develops a new statistical model with free SAS macros that can be applied to characterize time-varying effects on ordinal responses. Our simulation study shows that the ordinal-scale time-varying effects model has ...
Watt Torquil - - 2014
Background and aimThyroid diseases are prevalent and chronic. With treatment, quality of life is restored in most, but not all patients. Construct validity of the thyroid-related quality of life questionnaire, ThyPRO, has been established by multi-trait scaling, but not evaluated with more elaborate methods. The purpose of the present study ...
Chung Eun-Sung ES Seoul National University of Science and Technology, Seoul, Republic of - - 2014
This study proposed a robust prioritization framework to identify the priorities of treated wastewater (TWW) use locations with consideration of various uncertainties inherent in the climate change scenarios and the decision-making process. First, a fuzzy concept was applied because future forecast precipitation and their hydrological impact analysis results displayed significant ...
Fan Ruzong R Biostatistics and Bioinformatics Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, United States of - - 2014
By using functional data analysis techniques, we developed generalized functional linear models for testing association between a dichotomous trait and multiple genetic variants in a genetic region while adjusting for covariates. Both fixed and mixed effect models are developed and compared. Extensive simulations show that Rao's efficient score tests of ...
Whelan Simon S Evolutionary Biology, Evolutionary Biology Centre, Uppsala University, SE Faculty of Life Sciences, University of Manchester, Manchester, UK - - 2014
Molecular phylogenetics is a powerful tool for inferring both the process and pattern of evolution from genomic sequence data. Statistical approaches, such as maximum likelihood and Bayesian inference, are now established as the preferred methods of inference. The choice of models that a researcher uses for inference is of critical ...
Awad Zaid Z Department of Surgery and Cancer , Imperial College, London; Department of Otolaryngology , St. Mary's Hospital, Imperial College Healthcare NHS Trust, London, United - - 2014
To demonstrate construct validity of the ovine model as a tool for training in endoscopic sinus surgery (ESS). Prospective, cross-sectional evaluation study. Over 18 consecutive months, trainees and experts were evaluated in their ability to perform a range of tasks (based on previous face validation and descriptive studies conducted by ...
Gonzàlez J J 1IRTA,Finca Camps i Armet,17121 - - 2014
A market conformity tool, based on technological meat quality parameters, was developed within the Q-PorkChains project, to be included in a global sustainability evaluation of pig farming systems. The specific objective of the market conformity tool was to define a scoring system based on the suitability of meat to elaborate ...
Xu Meng M Carnegie Institution for Science, Department of Plant Biology, 260 Panama Street, Stanford CA 94305, - - 2014
Plant biology is becoming a data-driven science. High-throughput technologies generate data quickly from molecular to ecosystem levels. Statistical and computational approaches enable describing and interpreting data quantitatively. We highlight the purpose, common problems, and general principles in data analysis. We use RNA sequencing (RNAseq) analysis to illustrate the rationale behind ...
Onukwugha Eberechukwu E Department of Pharmaceutical Health Services Research, University of Maryland School of Pharmacy, 220 Arch Street, 12th Floor, Baltimore, MD, 21201, USA, - - 2014
Marginal analysis evaluates changes in an objective function associated with a unit change in a relevant variable. The primary statistic of marginal analysis is the marginal effect (ME). The ME facilitates the examination of outcomes for defined patient profiles while measuring the change in original units (e.g., costs, probabilities). The ...
Chen Shyi-Ming - - 2014
In this paper, we propose a new weighted fuzzy interpolative reasoning method for sparse fuzzy rule-based systems based on the slopes of fuzzy sets. We also propose a particle swarm optimization (PSO)-based weights-learning algorithm to automatically learn the optimal weights of the antecedent variables of fuzzy rules for weighted fuzzy ...
Anderman Eric M EM The Ohio State University, Columbus, Ohio, - - 2014
There is much interest in assessing growth in student learning. Assessments of growth have important implications and affect many policy decisions at many levels. In the present article, we review some of the different approaches to measuring growth and examine the implications of their usage. Samples used in research on ...
Ramsingh Davinder D Department of Anesthesiology, University of California at Irvine Medical Center, Orange, CA 92868, USA. Electronic address: - - 2014
To expose residents to two methods of education for point-of-care ultrasound, a traditional didactic lecture and a model/simulation-based lecture, which focus on concepts of cardiopulmonary function, volume status, and evaluation of severe thoracic/abdominal injuries; and to assess which method is more effective. Single-center, prospective, blinded trial. University hospital. Anesthesiology residents ...
Lensink Marc F MF CNRS USR3078, University Lille North of France, Parc de la Haute Borne, 50 avenue de Halley, F-59658, Villeneuve d'Ascq, - - 2014
CAPRI (Critical Assessment of PRedicted Interactions) has proven to be a catalyst for the development of docking algorithms. An essential step in docking is the scoring of predicted binding modes in order to identify stable complexes. In 2005, CAPRI introduced the scoring experiment, where upon completion of a prediction round, ...
Price Mathew M Neurobehavioral Research, Inc., Ala Moana Pacific Center, 1585 Kapiolani Blvd. Suite 1030, Honolulu, HI - - 2014
Although the human cerebellum has been increasingly identified as an important hub that shows potential for helping in the diagnosis of a large spectrum of disorders, such as alcoholism, autism, and fetal alcohol spectrum disorder, the high costs associated with manual segmentation, and low availability of reliable automated cerebellar segmentation ...
Michel Mirco M Department of Biochemistry and Biophysics, Stockholm University, 10691 Stockholm, Sweden, Science for Life Laboratory, Stockholm University, Box 1031, 17121 Solna, Sweden, Department of Systems Biology, Harvard Medical School, Boston, MA, USA, Department of Information and Computer Science, Aalto University, PO Box 15400, FI-00076 Aalto, Finland and Computational Biology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA Department of Biochemistry and Biophysics, Stockholm University, 10691 Stockholm, Sweden, Science for Life Laboratory, Stockholm University, Box 1031, 17121 Solna, Sweden, Department of Systems Biology, Harvard Medical School, Boston, MA, USA, Department of Information and Computer Science, Aalto University, PO Box 15400, FI-00076 Aalto, Finland and Computational Biology, Memorial Sloan-Kettering Cancer Center, New York, NY, - - 2014
Recently it has been shown that the quality of protein contact prediction from evolutionary information can be improved significantly if direct and indirect information is separated. Given sufficiently large protein families, the contact predictions contain sufficient information to predict the structure of many protein families. However, since the first studies ...
Gobbi Andrea A Fondazione Bruno Kessler, I-38100 Povo (Trento), Italy, European Molecular Biology Laboratory, European Bioinformatics Institute, Cambridge CB10 1SD, UK, Wellcome Trust Sanger Institute, Cambridge CB10 1SD, UK and Universitat Pompeu Fabra, Barcelona 08003, - - 2014
Studying combinatorial patterns in cancer genomic datasets has recently emerged as a tool for identifying novel cancer driver networks. Approaches have been devised to quantify, for example, the tendency of a set of genes to be mutated in a 'mutually exclusive' manner. The significance of the proposed metrics is usually ...
Oates Chris J CJ Department of Statistics, University of Warwick, Coventry, CV4 7AL, MRC Biostatistics Unit, Cambridge, CB2 0SR, UK, Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94710, Department of Biomedical Engineering, Knight Cancer Institute, Oregon Health and Science University, Portland, OR 97239-3098, USA and School of Clinical Medicine, University of Cambridge, Cambridge, CB2 0SP, - - 2014
Networks are widely used as structural summaries of biochemical systems. Statistical estimation of networks is usually based on linear or discrete models. However, the dynamics of biochemical systems are generally non-linear, suggesting that suitable non-linear formulations may offer gains with respect to causal network inference and aid in associated prediction ...
Lindgren O O Department of Behavioural Sciences and Philosophy, Unit of Philosophy, University of Turku, - - 2014
There are several different approaches in the treatment of alcohol dependence. These approaches can be generalized into two different treatment paradigms. Explanatory models are theories that answer to the question about the nature of alcohol dependence and what kind of condition it should be thought as. My aim is to ...
Khan Kamran A KA Warwick Clinical Trials Unit, Division of Health Sciences, Warwick Medical School, University of Warwick, Coventry, UK. Electronic address: - - 2014
The Roland Morris Questionnaire (RMQ) is a widely used health status measure for low back pain (LBP). It is not preference-based, and there are currently no established algorithms for mapping between the RMQ and preference-based health-related quality-of-life measures. Using data from randomized controlled trials of treatment for LBP, we sought ...
Kim Sang-Phil SP Krannert School of Management, Purdue University, West Lafayette, IN, - - 2014
Simulated allocation models (SAMs) are used to evaluate organ allocation policies. An important component of SAMs is a module that decides whether each potential recipient will accept an offered organ. The objective of this study was to develop and test accept-or-decline classifiers based on several machine-learning methods in an effort ...
Adabor Emmanuel S ES Department of Mathematics, Kwame Nkrumah University of Science and Technology, PMB, Kumasi, Ghana. Electronic address: - - 2014
Bayesian Networks have been used for the inference of transcriptional regulatory relationships among genes, and are valuable for obtaining biological insights. However, finding optimal Bayesian Network (BN) is NP-hard. Thus, heuristic approaches have sought to effectively solve this problem. In this work, we develop a hybrid search method combining Simulated ...
Gentes Emily L EL Durham Veterans Affairs Medical Center, Durham, NC, USA; The VA Mid-Atlantic Mental Illness Research, Education, and Clinical Center, Durham, NC, USA. Electronic address: - - 2014
Posttraumatic stress disorder (PTSD) is a significant problem among Iraq/Afghanistan-era veterans. To date, however, there has been only limited research on how the recent changes in DSM-5 influence the prevalence and factor structure of PTSD. To address this key issue, the present research used a modified version of a gold-standard ...
Stummer C C Department of Rehabilitation Sciences , KU Leuven, Leuven , Belgium - - 2014
Abstract Purpose: To develop prognostic models and equations for predicting participation at six months after stroke. Methods: This European prospective cohort study recruited 532 consecutive patients from four rehabilitation centers. Participation was assessed at six months after stroke with the Sickness Impact Profile (SIP), which consists of a physical, psychosocial ...
Chen Gang - - 2014
BackgroundThe KIDSCREEN-10 index and the Child Health Utility 9D (CHU9D) are two recently developed generic instruments for the measurement of health-related quality of life in children and adolescents. Whilst the CHU9D is a preference based instrument developed specifically for application in cost-utility analyses, the KIDSCREEN-10 is not currently suitable for ...
Jarquín Diego - - 2014
Advances in genotyping technology, such as genotyping by sequencing (GBS), are making genomic prediction more attractive to reduce breeding cycle times and costs associated with phenotyping. Genomic prediction and selection has been studied in several crop species, but no reports exist in soybean. The objectives of this study were (i) ...
Bardou Philippe - - 2014
Venn diagrams are commonly used to display list comparison. In biology, they are widely used to show the differences between gene lists originating from different differential analyses, for instance. They thus allow the comparison between different experimental conditions or between different methods. However, when the number of input lists exceeds ...
Xu Xu Steven XS Model-Based Drug Development, Janssen Research and Development, 920 Route 202, Raritan, New Jersey, USA, - - 2014
Mixed-effects beta regression (BR), boundary-inflated beta regression (ZOI), and coarsening model (CO) were investigated for analyzing bounded outcome scores with data at the boundaries in the context of Alzheimer's disease. Monte Carlo simulations were conducted to simulate disability assessment for dementia (DAD) scores using these three models, and each set ...
Dawson Jeffrey J RSPB Centre for Conservation Science, Royal Society for the Protection of Birds, The Lodge, Sandy, Bedfordshire, SG19 2DL, United - - 2014
Invasive alien species are one of the primary threats to native biodiversity on islands worldwide. Consequently, eradicating invasive species from islands has become a mainstream conservation practice. Deciding which islands have the highest priority for eradication is of strategic importance to allocate limited resources to achieve maximum conservation benefit. Previous ...
Bille Todd W TW Bureau of Alcohol, Tobacco, Firearms and - - 2014
DNA analyses from forensic casework samples commonly result in complex DNA profiles. Often, these profiles consist of multiple contributors and display multiple stochastic events such as peak height imbalance, allelic or locus drop-out, allelic drop-in, and excessive or indistinguishable stutter. This increased complexity has established a need for more sophisticated ...
Dauwe Samuel S Department of Information Technology (INTEC) - IBCN, Ghent University - iMinds, Gaston Crommenlaan 8 bus 201, B-9050 Gent, Belgium. - - 2014
The growing concern of citizens about the quality of their living environment and the emergence of low-cost microphones and data acquisition systems triggered the deployment of numerous noise monitoring networks spread over large geographical areas. Due to the local character of noise pollution in an urban environment, a dense measurement ...
Ford Eric E Dept. of Computer Science, Graduate Center, CUNY, New York, NY, 10016, - - 2014
Finding the optimal evolutionary history for a set of taxa is a challenging computational problem, even when restricting possible solutions to be "tree-like" and focusing on the maximum-parsimony optimality criterion. This has led to much work on using heuristic tree searches to find approximate solutions. We present an approach for ...
Gavett Brandon E - - 2014
Objective: Royall and colleagues identified a latent dementia phenotype, "δ", reflecting the "cognitive correlates of functional status." We sought to cross-validate and extend these findings in a large clinical case series of adults with and without dementia. Method: A confirmatory factor analysis (CFA) model for δ was fit to National ...
Sanassy Daven - - 2014
Stochastic simulation algorithms (SSAs) are used to trace realistic trajectories of biochemical systems at low species concentrations. As the complexity of modelled bio-systems increases, it is important to select the best performing SSA. Numerous improvements to SSAs have been introduced but they each only tend to apply to a certain ...
Kratz Jadel M - - 2014
The goal of this study was to design, experimentally validate, and apply a virtual screening workflow to identify novel hERG channel blockers. The hERG channel is an important antitarget in drug development, since cardiotoxic risks remain as a major cause of attrition. A ligand-based pharmacophore model collection was developed and ...
Radu Alex A 1 School of Information Technologies, The University of Sydney , Sydney, Australia - - 2014
Abstract With the continuing increase in availability of biological data and improvements to biological models, biological network analysis has become a promising area of research. An emerging technique for the analysis of biological networks is through network alignment. Network alignment has been used to calculate genetic distance, similarities between regulatory ...
Githeko Andrew K - - 2014
Malaria epidemics remain a serious threat to human populations living in the highlands of East Africa where transmission is unstable and climate sensitive. An existing early malaria epidemic prediction model required further development, validations and automation before its wide use and application in the region. The model has a lead-time ...
Doble Brett B Centre for Health Economics, Faculty of Business and Economics, Monash University, Room 278, Level 2, Building 75 Monash University, Clayton, Victoria 3800, - - 2014
The successful use of a targeted therapy is intrinsically linked to the ability of a companion diagnostic to correctly identify patients most likely to benefit from treatment. The aim of this study was to review the characteristics of companion diagnostics that are of importance for inclusion in an economic evaluation. ...
Mullon C C Department of Ecology and Evolution, University of Lausanne, Lausanne, - - 2014
The weak selection approximation of population genetics has made possible the analysis of social evolution under a considerable variety of biological scenarios. Despite its extensive usage, the accuracy of weak selection in predicting the emergence of altruism under limited dispersal when selection intensity increases remains unclear. Here, we derive the ...
MacMillan Gordon J GJ Matrix Solutions Inc., Suite 200, 150-13 Avenue SW, Calgary, Alberta, Canada T2R - - 2014
Many hydrogeology problems require predictions of hydraulic heads in a supply well. In most cases, the regional hydraulic response to groundwater withdrawal is best approximated using a numerical model; however, simulated hydraulic heads at supply wells are subject to errors associated with model discretization and well loss. An approach for ...
Chauvet Pierre E PE LARIS EA7315, L׳UNAM Université, Université Catholique de l׳Ouest, 3 place André-Leroy BP 10808, 49008 Angers, France. Electronic address: - - 2014
In this paper, we present a new method to compare and improve algorithms for feature detection in neonatal EEG. The method is based on the algorithm׳s ability to compute accurate statistics to predict the results of EEG visual analysis. This method is implemented inside a Java software called EEGDiag, as ...
Liu Mona Mengyue MM University of Pittsburgh School of Medicine, Department of Otolaryngology, 3550 Terrace Street, Pittsburgh, PA 15261, United - - 2014
The double-opposing Z-plasty (Furlow palatoplasty) procedure is a well-established method for palate repair in children. We propose a simple and easily accessible sticky note model to demonstrate the lengthening in palatal anatomy afforded by this technically challenging procedure. Our model involves creating a lengthened three-dimensional representation of the Z-plasty through ...
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