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Tortajada Salvador S IBIME, Instituto de Aplicaciones de las Tecnologías de la Información y de las Comunicaciones Avanzadas (ITACA), Universitat Politècnica de València, Valencia, Spain, - - 2015
In the last decades, and following the new trends in medicine, statistical learning techniques have been used for developing automatic diagnostic models for aiding the clinical experts throughout the use of Clinical Decision Support Systems. The development of these models requires a large, representative amount of data, which is commonly ...
Pawelek Kasia A KA Department of Mathematics and Computational Science, University of South Carolina Beaufort, Bluffton, SC 29909, United States. - - 2014
Influenza remains a serious public-health problem worldwide. The rising popularity and scale of social networking sites such as Twitter may play an important role in detecting, affecting, and predicting influenza epidemics. In this paper, we develop a simple mathematical model including the dynamics of ``tweets'' --- short, 140-character Twitter messages ...
Park Minsu M Animal Genomics and Bioinformatics Division, National Institute of Animal Science, RDA, Suwon 441-706, Korea - - 2014
This study considers a problem of genomic selection (GS) for adjacent genetic markers of Yorkshire pigs which are typically correlated. The GS has been widely used to efficiently estimate target variables such as molecular breeding values using markers across the entire genome. Recently, GS has been applied to animals as ...
Vessey Judith J Boston College, William F. Connell School of Nursing, 140 Commonwealth Ave., Cushing Hall, Room 427, Chestnut Hill, MA 02467. - - 2014
Bullying is a significant problem in schools and measuring this concept remains problematic. The purposes of this study were to (1) identify the published self-report measures developed to assess youth bullying; (2) evaluate their psychometric properties and instrument characteristics; and (3) evaluate the quality of identified psychometric papers evaluating youth ...
Perich Carmen - - 2014
Abstract Background: Numerical data on the components of biological variation (BV) have many uses in laboratory medicine, including in the setting of analytical quality specifications, generation of reference change values and assessment of the utility of conventional reference values. Methods: Generation of a series of up-to-date comprehensive database of components ...
Majdan Marek - - 2014
BackgroundExternal validation on different TBI populations is important in order to assess the generalizability of prognostic models to different settings. We aimed to externally validate recently developed models for prediction of six month unfavourable outcome and six month mortality.MethodsThe International Neurotrauma Research Organization ¿ Prehospital dataset (INRO-PH) was collected within ...
Rahman Tameera T Department of Computing, University of Surrey, Guildford, GU2 7XH, United - - 2014
In vitro and in vivo selection of vaccines is time consuming, expensive and the selected vaccines may not be able to provide protection against broad-spectrum viruses because of emerging antigenically novel disease strains. A powerful computational model that incorporates these protein/DNA or RNA level fluctuations can effectively predict antigenically variant ...
Brown Connolly Nancy E NE Department of Engineering, Information Systems, and Computing, Brunel University , Uxbridge, United Kingdom - - 2014
Abstract Background: This foundational study applies the process of receiver operating characteristic (ROC) analysis to evaluate utility and predictive value of a disease management (DM) model that uses RM devices for chronic obstructive pulmonary disease (COPD). The literature identifies a need for a more rigorous method to validate and quantify ...
Rämisch Sebastian S Department of Biochemistry and Structural Biology, Center for Molecular Protein Science, Lund University, - - 2014
Homomeric coiled-coils can self-assemble into a wide range of structural states with different helix topologies and oligomeric states. In this study, we have combined de novo structure modeling with stability calculations to simultaneously predict structure and oligomeric states of homomeric coiled-coils. For dimers an asymmetric modeling protocol was developed. Modeling ...
Olatunji Bunmi O - - 2014
The current research evaluated a bifactor model for the Three Domains of Disgust Scale (TDDS) in 2 undergraduate samples. The goals were (a) to evaluate whether the TDDS should be scored as a unidimensional scale or whether subscales of pathogen, sex, and moral disgust should be additionally interpreted, and (b) ...
Oc Burak - - 2014
Subordinates are often seen as impotent, able to react to but not affect how powerholders treat them. Instead, we conceptualize subordinate feedback as an important trigger of powerholders' behavioral self-regulation and explore subordinates' reciprocal influence on how powerholders allocate resources to them over time. In 2 experiments using a multiparty, ...
Meinhardt Marcus W MW Institute of Psychopharmacology, University of Heidelberg, - - 2014
Rational development of novel therapeutic strategies for alcoholism requires understanding of its underlying neurobiology and pathophysiology. Obtaining this knowledge largely relies on animal studies. Thus, choosing the appropriate animal model is one of the most critical steps in pre-clinical medication development. Among the range of animal models that have been ...
Koo Imhoi I Department of Chemistry, University of Louisville, Louisville, KY 40292, - - 2014
The goal of metabolic association networks is to identify topology of a metabolic network for a better understanding of molecular mechanisms. An accurate metabolic association network enables investigation of the functional behavior of metabolites in a cell or tissue. Gaussian Graphical model (GGM)-based methods have been widely used in genomics ...
Lamy J-B JB Jean-Baptiste Lamy, LIMICS - Bureau 149 Université Paris 13, 74 rue Marcel Cachin, 93017 Bobigny, France, E-mail: - - 2014
Background: Each year, the International Medical Informatics Association Yearbook recognizes significant scientific papers, labelled as "best papers", published the previous year in the subfields of biomedical informatics that correspond to the different section topics of the journal. For each section, about fifteen pre-selected "candidate" best papers are externally peer-reviewed to ...
Yang Hanyu H Department of Statistics, Pennsylvania State University, University Park, PA 16802, - - 2014
This study proposes a generalized time-varying effect model that can be used to characterize a discrete longitudinal covariate process and its time-varying effect on a later outcome that may be discrete. The proposed method can be applied to examine two important research questions for daily process data: measurement reactivity and ...
Achdou Yves Y Université Paris Diderot, Sorbonne Paris Cité, Laboratoire Jacques-Louis Lions, Paris, - - 2014
The purpose of this article is to get mathematicians interested in studying a number of partial differential equations (PDEs) that naturally arise in macroeconomics. These PDEs come from models designed to study some of the most important questions in economics. At the same time, they are highly interesting for mathematicians ...
Jaramillo-O N N Instituto de Biología, Facultad de Ciencias Exactas y Naturales, Universidad de Antioquia UdeA, Medellín, - - 2014
The subgenus Anopheles (Nyssorhynchus) (Diptera: Culicidae) includes the primary vectors of Plasmodium spp. in Colombia. Most adult females of this subgenus are difficult to identify in the field using the available keys. With the objective of further investigating the discriminatory power of modern morphometrics, both landmark-based and outline-based approaches were ...
Loux Travis M TM Department of Biostatistics, Saint Louis University College for Public Health and Social Justice, Saint Louis, MO, - - 2014
In many experimental situations, researchers have information on a number of covariates prior to randomization. This information can be used to balance treatment assignment with respect to these covariates as well as in the analysis of the outcome data. In this paper, we investigate the use of propensity scores in ...
Khazraee S Hadi SH Zachry Department of Civil Engineering, Texas A&M University, College Station, TX, - - 2014
The hyper-Poisson distribution can handle both over- and underdispersion, and its generalized linear model formulation allows the dispersion of the distribution to be observation-specific and dependent on model covariates. This study's objective is to examine the potential applicability of a newly proposed generalized linear model framework for the hyper-Poisson distribution ...
Borgström F F Quantify Research, Stockholm, Sweden, - - 2014
We reviewed all peer-reviewed papers analysing the cost-effectiveness of vertebroplasty and balloon kyphoplasty for osteoporotic vertebral compression fractures. In general, the procedures appear to be cost effective but are very dependent upon model input details. Better data, rather than new models, are needed to answer outstanding questions. Vertebral augmentation procedures ...
Serra Sónia R Q SR IMAR-CMA, Marine and Environmental Research Centre, A/c Department of Life Sciences, Faculty of Science and Technology, University of Coimbra, Largo Marquês de Pombal, 3004-517, Coimbra, Portugal, - - 2015
Bioassessment tools should distinguish between the effects of anthropogenic degradation in communities and natural temporal changes. The present study tests the influence of natural seasonal variability on macroinvertebrate stream communities assessed by a predictive model (PORTRIV) and a multimetric index (IPtI) calibrated for spring. The scores of PORTRIV decreased significantly ...
Yan Xiao-Yong XY School of Systems Science, Beijing Normal University, Beijing 100875, People's Republic of China Department of Transportation Engineering, Shijiazhuang Tiedao University, Shijiazhuang 050043, People's Republic of - - 2014
Despite the long history of modelling human mobility, we continue to lack a highly accurate approach with low data requirements for predicting mobility patterns in cities. Here, we present a population-weighted opportunities model without any adjustable parameters to capture the underlying driving force accounting for human mobility patterns at the ...
Mutsvangwa Tinashe - - 2014
This work presents development of statistical shape models based on robust and rigid-groupwise registration followed by pointset non-rigid registration. The main advantages of the pipeline include automation in that the method does not rely on manual landmarks or a regionalization step; there is no bias in the choice of reference ...
McArdle John J JJ Department of Psychology, University of Southern California, SGM 501, Los Angeles, CA, 90089, USA, - - 2014
This is a short story about John C. Loehlin who is now at the University of Texas at Austin, dealing with his original simulation models and developments, which led to his current latent variable models. This talk was initially presented at a special meeting for John before the BGA in ...
Jepsen Peter P Department of Hepatology and Gastroenterology, Aarhus University Hospital, Aarhus, Denmark; Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, - - 2014
Multi-state models are models of disease progression that for a patient group define multiple outcome events, each of which may affect the time to develop another outcome event. Multi-state models are highly relevant for studies of cirrhosis patients; both the classical perception of cirrhosis as either compensated or decompensated and ...
Deng Yi Y Department of Biostatistics and Bioinformatics, Emory University, Atlanta, GA, - - 2014
In multi-regional trials, the underlying overall and region-specific accrual rates often do not hold constant over time and different regions could have different start-up times, which combined with initial jump in accrual within each region often leads to a discontinuous overall accrual rate, and these issues associated with multi-regional trials ...
Yang Wen-Yun WY University of California, Los - - 2014
Ancestry analysis from genetic data plays a critical role in studies of human disease and evolution. Recent work has introduced explicit models for the geographic distribution of genetic variation and has shown that such explicit models yield superior accuracy in ancestry inference over non-model-based methods. Here we extend such work ...
Bassiou Nikoletta K - - 2014
A novel method is proposed for updating an already trained asymmetric and symmetric probabilistic latent semantic analysis (PLSA) model within the context of a varying document stream. The proposed method is coined online PLSA (oPLSA). The oPLSA employs a fixed-size moving window over a document stream to incorporate new documents ...
Easton Brian B Social and Health Outcomes Research and Evaluation (SHORE), Massey University, Auckland, New - - 2014
ABSTRACT. The purpose of this study was to estimate the productivity losses due to morbidity of individuals with fetal alcohol spectrum disorder (FASD). A demographic approach was used. Population estimates were calculated using data for the most recent available year (i.e., 2011) on the population of Canada by provinces, the ...
Buckingham Michael J MJ Marine Physical Laboratory, Scripps Institution of Oceanography, University of California, San Diego, 9500 Gilman Drive, La Jolla, California - - 2014
Chotiros and Isakson [J. Acoust. Soc. Am. 135, 3264-3279 (2014)] contend that the physics-based grain-shearing (GS) theories of wave propagation in granular materials are not consistent with one particular shear-attenuation data set for water-saturated angular sand that has appeared in the literature. This provides them with the rationale for developing ...
Liu Yulun Y Division of Biostatistics, The University of Texas School of Public Health, Houston, Texas 77030, - - 2014
Several statistical methods for meta-analysis of diagnostic accuracy studies have been discussed in the presence of a gold standard. However, in practice, the selected reference test may be imperfect due to measurement error, non-existence, invasive nature, or expensive cost of a gold standard. It has been suggested that treating an ...
Caccese Jaclyn B JB Department of Kinesiology and Applied Physiology, University of Delaware, Newark, - - 2014
The Balance Error Scoring System (BESS) is the current standard for assessing postural stability in concussed athletes on the sideline. However, research has questioned the objectivity and validity of the BESS, suggesting that while certain subcategories of the BESS have sufficient reliability to be used in evaluation of postural stability, ...
Liu Jing - - 2014
Adaptive predictor has long been used for lossless predictive coding of images. Most of existing lossless predictive coding techniques mainly focus on suitability of prediction model for training set with the underlying assumption of local consistency, which may not hold well on object boundaries and cause large predictive error. In ...
Vesely M M Institute of Chemical Process Fundamentals, AS CR, v. v. i., Rozvojova 135, 165 02, Prague 6, Czech - - 2014
Polybrominated diphenyl ethers (PBDE) were, and in some countries still are, used as flame retardants for plastic materials. When released from plastics, PDBE cause harm to the environment. This creates the incentive for further investigation of the PBDE degradation. This work focused on a formulation of a PBDE photodegradation model ...
Daniel R M RM Centre for Statistical Methodology, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, - - 2014
In diverse fields of empirical research-including many in the biological sciences-attempts are made to decompose the effect of an exposure on an outcome into its effects via a number of different pathways. For example, we may wish to separate the effect of heavy alcohol consumption on systolic blood pressure (SBP) ...
Konishi Takuya - - 2014
Network data show the relationship among one kind of objects, such as social networks and hyperlinks on the Web. Many statistical models have been proposed for analyzing these data. For modeling cluster structures of networks, the infinite relational model (IRM) was proposed as a Bayesian nonparametric extension of the stochastic ...
Fogliata Antonella - - 2014
BackgroundTo evaluate in-silico the performance of a model-based optimization process for volumetric modulated arc therapy (RapidArc) applied to hepatocellular cancer treatments.Patients and methods45 clinically accepted RA plans were selected to train a knowledge-based engine for the prediction of individualized dose-volume constraints. The model was validated on the same plans used ...
Schmidtmann I I Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Center of the Johannes Gutenberg University Mainz, - - 2014
For determining a manageable set of covariates potentially influential with respect to a time-to-event endpoint, Cox proportional hazards models can be combined with variable selection techniques, such as stepwise forward selection or backward elimination based on p-values, or regularized regression techniques such as component-wise boosting. Cox regression models have also ...
Chen Gong G Roche Pharmaceutical Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center New York, Roche TCRC, Inc., 430 East 29th Street, New York, NY 10016, - - 2014
Patients often respond differently to a treatment because of individual heterogeneity. Failures of clinical trials can be substantially reduced if, prior to an investigational treatment, patients are stratified into responders and nonresponders based on biological or demographic characteristics. These characteristics are captured by a predictive signature. In this paper, we ...
Falkenström Fredrik - - 2014
Recently, researchers have started to measure the working alliance repeatedly across sessions of psychotherapy, relating the working alliance to symptom change session by session. Responding to questionnaires after each session can become tedious, leading to careless responses and/or increasing levels of missing data. Therefore, assessment with the briefest possible instrument ...
Macera Márcia A C MA PPGEs, Universidade Federal de São Carlos, São Carlos, SP, - - 2014
In this paper, we introduce a new model for recurrent event data characterized by a baseline rate function fully parametric, which is based on the exponential-Poisson distribution. The model arises from a latent competing risk scenario, in the sense that there is no information about which cause was responsible for ...
Motoyama Hiroaki H First Department of Surgery, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano, 390-8621, - - 2014
The aim of this study was to construct a prediction model for posthepatectomy liver failure (PHLF), as defined by the International Study Group of Liver Surgery, and evaluate its accuracy in hepatocellular carcinoma (HCC) patients with cirrhosis or chronic hepatitis. A total of 277 consecutive hepatectomies for HCC between 2005 ...
Ntalampiras Stavros - - 2014
This paper proposes a holistic modeling scheme for fault identification in distributed sensor networks. The proposed scheme is based on modeling the relationship between two datastreams by means of a hidden Markov model (HMM) trained on the parameters of linear time-invariant dynamic systems, which estimate the specific relationship over consecutive ...
Arima Serena S Dipartimento di Metodi e Modelli per l'Economia, il Territorio e la Finanza, Sapienza Università di Roma, Rome, - - 2014
With reference to a questionnaire that aimed to assess the quality of life for dysarthric speakers, we investigate the usefulness of a model-based procedure for reducing the number of items. We propose a mixed cumulative logit model, which is known in the psychometrics literature as the graded response model: responses ...
Kelemen Adám A AA Medicinal Chemistry Research Group, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Magyar Tudósok Körútja 2, Budapest, 1117, - - 2014
A physicochemical property-based desirability scoring scheme for fragment-based drug discovery was developed for class A aminergic GPCR targeted fragment libraries. Physicochemical property distributions of known aminergic GPCR-active fragments from the ChEMBL database were examined and used for a desirability function-based score. Property-distributions such as log D (at pH 7.4), PSA, pKa ...
Li Meili M School of Science, Donghua University, Shanghai, 201620, China, - - 2014
A network epidemic SIWR model for cholera and other diseases that can be transmitted via the environment is developed and analyzed. The person-to-person contacts are modeled by a random contact network, and the contagious environment is modeled by an external node that connects to every individual. The model is adapted ...
Kuan Pei Fen - - 2014
Abstract It has been proposed recently that differentially variable CpG methylation (DVC) may contribute to transcriptional aberrations in human diseases. In large scale epigenetic studies, potential confounders could affect the observed methylation variabilities and need to be accounted for. In this paper, we develop a robust statistical model for differential ...
Saleh M I MI Faculty of Pharmacy, The University of Jordan, Amman, - - 2014
Introduction: The present analysis describes the longitudinal change in buprenorphine treatment outcome. It also examines several participant characteristics to predict response to buprenorphine. Methods: Participants (n=501, age>15 years) received buprenorphine/naloxone treatment for 4 weeks, and then were randomly assigned to undergo dose tapering over either 7 days or 28 days. ...
Kraemer Helena Chmura HC Department of Psychiatry and Behavioral Sciences, Stanford University (Emerita), Palo Alto, CA - - 2014
Does the McFarlane et al study(1) provide a model for practical trials? Unfortunately, not. The methodological problems are here reviewed and used as a springboard to set out methodological criteria that might define such a model.
Musoro Jammbe Z - - 2014
In prognostic studies, the lasso technique is attractive since it improves the quality of predictions by shrinking regression coefficients, compared to predictions based on a model fitted via unpenalized maximum likelihood. Since some coefficients are set to zero, parsimony is achieved as well. It is unclear whether the performance of ...
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