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Gibiansky Leonid L QuantPharm LLC, North Potomac, MD, USA, - - 2014
This work proposes and evaluates two methods (CM1 and CM2) for detecting non-compliance using concentration-time data and for obtaining estimates of population pharmacokinetic model parameters in a population with prevalent non-compliance. CM1 estimates individual residual variability (RV) and identifies subjects with higher than average RV as non-compliant. Exclusion of subjects ...
Sayadi Omid O Massachusetts General Hospital, Harvard Medical - - 2014
The ability to accurately monitor tidal volume (TV) from ECG signals holds significant promise for improving diagnosis, treatment across a variety of clinical settings. The objective of this study was to develop a novel method for estimating the TV from electrocardiographic (ECG) signals. In ten mechanically-ventilated swine we collected intracardiac ...
Hansen Christopher L CL Section of Cardiology, Jefferson Heart Institute, Thomas Jefferson University, 925 Chestnut Street, Mezzanine, Philadelphia, PA, USA, - - 2014
Fourier (cosine) analysis of time activity curves (TAC) of radionuclide ventriculography (RVG) may oversimplify the TAC and has limitations. We identified 21 patients who had undergone 24 frame planar RVG with ejection fractions ranging from 8% to 76% (43% ± 19%). The TAC for each pixel was fitted to both a cosine ...
Gao Hao H School of Mathematics and Statistics, University of Glasgow, Glasgow, - - 2014
Finite stress and strain analyses of the heart provide insight into the biomechanics of myocardial function and dysfunction. Herein, we describe progress towards dynamic patient-specific models of the left ventricle using an immersed boundary (IB) method with a finite element (FE) structural mechanics model. We use a structure-based hyperelastic strain-energy ...
Lutz Oliver M D OM Institute of Analytical Chemistry and Radiochemistry, Center for Chemistry and Biomedicine, Leopold-Franzens University, Innsbruck, Innrain 80-82, 6020 Innsbruck, - - 2014
This work describes the modification of an InGaAs diode array detector equipped miniaturized near-infrared (NIR) spectrometer enabling the reliable quantification of ethanol blended gasoline. A transflectance measurement cell is presented, utilizing a thermoelectric cooling (TEC) appliance ensuring thermostatic measurement conditions and a gold-coated spherical mirror as a reflector superior to ...
Wang Zhijie - - 2014
Accurate estimation of the ventricular volumes is essential to the assessment of global cardiac functions. The existing estimation methods are mostly restricted to the left ventricle (LV), and often require segmentation which is challenging and computationally expensive. This paper proposes to estimate the volumes of both LV and right ventricle ...
Lekadir Karim - - 2014
This paper presents a predictive framework for the statistical personalization of ventricular fibers. To this end, the relationship between subject-specific geometry of the left (LV) and right ventricles (RV) and fiber orientation is learned statistically from a training sample of ex vivo diffusion tensor imaging datasets. More specifically, the axes ...
Silva Catarina C Urban Water Division, Hydraulics and Environment Department, LNEC - National Civil Engineering Laboratory, Av. Brasil 101, 1700-066 Lisboa, - - 2014
Removal efficiencies are often used to assess the performance of a single or a group of unit operations/processes (UOPs) of a wastewater treatment plant (WWTP). However, depending on the influent concentration (Cin), the same efficiency of removal (Er) may be insufficient or excessive to achieve the UOP or WWTP effluent ...
Shao Lijing L Max-Planck-Institut für Radioastronomie, Auf dem Hügel 69, D-53121 Bonn, Germany and School of Physics, Peking University, Beijing 100871, - - 2014
The standard model extension is an effective field theory introducing all possible Lorentz-violating (LV) operators to the standard model and general relativity (GR). In the pure-gravity sector of minimal standard model extension, nine coefficients describe dominant observable deviations from GR. We systematically implemented 27 tests from 13 pulsar systems to ...
Auger Daniel A - - 2014
The most time consuming and limiting step in three dimensional (3D) cine displacement encoding with stimulated echoes (DENSE) MR image analysis is the demarcation of the left ventricle (LV) from its surrounding anatomical structures. The aim of this study is to implement a semi-automated segmentation algorithm for 3D cine DENSE ...
Keshavarz-Motamed Zahra Z Laboratory of Biorheology and Medical Ultrasonics, University of Montreal Hospital Research Center (CRCHUM), Montréal, Québec, Canada ; Laboratory of Cardiovascular Fluid Dynamics, Mechanical and Industrial Engineering, Concordia University, Montréal, Québec, - - 2014
Early detection and accurate estimation of aortic stenosis (AS) severity are the most important predictors of successful long-term outcomes in patients. Current clinical parameters used for evaluation of the AS severity have several limitations including flow dependency. Estimation of AS severity is specifically challenging in patients with low-flow and low ...
Ketout Hussin H 0000-0001-8849-9309 Electrical and Computer Engineering, Dalhousie University, 1360 Barrington Street, Halifax, NS, Canada B3J - - 2014
This paper presents a framework for tracking left ventricular (LV) endocardium through 2D echocardiography image sequence. The framework is based on fusion of biomechanical (BM) model of the heart with the parametric deformable model. The BM model constitutive equation consists of passive and active strain energy functions. The deformations of ...
Polidori Carlo C Departamento de Biodiversidad y Biología Evolutiva, Museo Nacional de Ciencias Naturales (CSIC), Madrid, - - 2014
Comparative studies on antennal sensillar equipment in insects are largely lacking, despite their potential to provide insights into both ecological and phylogenetic relationships. Here we present the first comparative study on antennal morphology and sensillar equipment in female Cynipoidea (Hymenoptera), a large and diverse group of wasps, with special reference ...
He Zongxiao Z Center for Statistical Genetics, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, - - 2014
Many population-based rare-variant (RV) association tests, which aggregate variants across a region, have been developed to analyze sequence data. A drawback of analyzing population-based data is that it is difficult to adequately control for population substructure and admixture, and spurious associations can occur. For RVs, this problem can be substantial, ...
Pluijmert Marieke - - 2013
It has been hypothesized that myofiber orientation adapts to achieve a preferred mechanical loading state in the myocardial tissue. Earlier studies tested this hypothesis in a combined model of left ventricular (LV) mechanics and remodeling of myofiber orientation in response to fiber cross-fiber shear, assuming synchronous timing of activation and ...
Basta Holly A HA Institute for Molecular Virology, University of Wisconsin, 1525 Linden Drive, Madison, WI 53706, United States of - - 2014
Human rhinoviruses of the RV-C species are recently discovered pathogens with greater clinical significance than isolates in the RV-A+B species. The RV-C cannot be propagated in typical culture systems; so much of the virology is necessarily derivative, relying on comparative genomics, relative to the better studied RV-A+B. We developed a ...
Nguyen Vinh-Tan - - 2013
Patient-specific computational fluid dynamics (CFD) modelling of the left ventricle (LV) is a promising technique for the visualisation of ventricular flow patterns throughout a cardiac cycle. While significant progress has been made in improving the physiological quality of such simulations, the methodologies involved for several key steps remain significantly operator-dependent ...
Nongpiur Monisha E - - 2013
To identify subgroups of primary angle-closure suspects (PACS) based on anterior segment optical coherence tomography (AS-OCT) and biometric parameters. Cross-sectional study. We evaluated 243 PACS subjects in the primary group and 165 subjects in the validation group. Participants underwent gonioscopy and AS-OCT (Carl Zeiss Meditec, Dublin, CA). Customized software (Zhongshan ...
Tan May-Ling - - 2013
This paper describes an automatic algorithm that uses a geometry-driven optimization approach to restore the shape of three-dimensional (3D) left ventricular (LV) models created from magnetic resonance imaging (MRI) data. The basic premise is to restore the LV shape such that the LV epicardial surface is smooth after the restoration ...
Rabbani Faride - - 2013
This study describes spectrometric monitored kinetic processes to determine the size of citrate-capped Au nanoparticles (Au NPs) based on aggregation induced by l-cysteine (l-Cys) as a molecular linker. The Au NPs association process is thoroughly dependent on pH, concentration and size of nanoparticles. Size dependency of aggregation inspirits to determine ...
Wan Min - - 2013
This study proposes a novel method to reconstruct the left cardiac structure from contours. Given the contours representing left ventricle (LV), left atrium (LA), and aorta (AO), re-orientation, contour matching, extrapolation, and interpolation are performed sequentially. The processed data are then reconstructed via a variational method. The weighted minimal surface ...
Mu Wei - - 2013
A new noninvasive estimation method for the plasma time-activity curve, i.e. input function (IF) of the tracer kinetic model in dynamic 18F-FDG microPET mouse studies, is proposed and validated. This estimation method comprises four steps. First, a novel constraint nonnegative matrix factorization (CNMF) segmentation algorithm was applied to extract the ...
Nambakhsh Cyrus M S - - 2013
A fundamental step in the diagnosis of cardiovascular diseases, automatic left ventricle (LV) segmentation in cardiac magnetic resonance images (MRIs) is still acknowledged to be a difficult problem. Most of the existing algorithms require either extensive training or intensive user inputs. This study investigates fast detection of the left ventricle ...
Deng Nina - - 2013
BACKGROUND: Relative validity (RV), a ratio of ANOVA F-statistics, is often used to compare the validity of patient-reported outcome (PRO) measures. We used the bootstrap to establish the statistical significance of the RV and to identify key factors affecting its significance. METHODS: Based on responses from 453 chronic kidney disease ...
Lentini Pia E - - 2013
Although the concept of connectivity is decades old, it remains poorly understood and defined, and some argue that habitat quality and area should take precedence in conservation planning instead. However, fragmented landscapes are often characterized by linear features that are inherently connected, such as streams and hedgerows. For these, both ...
Veress A I - - 2013
A series of models were developed in which a circulatory system model was coupled to an existing series of finite element (FE) models of the left ventricle (LV). The circulatory models were used to provide realistic boundary conditions for the LV models. This was developed for the JSim analysis package ...
Patel Parul P School of Pharmacy, De Montfort University, Leicester, - - 2013
Dried blood spots (DBS) alongside micro-analytical techniques are a potential solution to the challenges of performing pharmacokinetic (PK) studies in children. However, DBS methods have received little formal evaluation in clinical settings relevant to children. The aim of the present study was to determine a PK model for caffeine using ...
Marwick Thomas H - - 2013
The last decade has produced a proliferation of techniques for the assessment of left ventricular systolic function, and there now seems to be more choice than seems rational for the questions that we need answers to. In some instances, simple estimation is all that is required-the risk stratification process is ...
Taylor Brian A BA Department of Radiological Sciences, St. Jude Children's Research Hospital, Memphis, TN 38105, - - 2013
To develop and evaluate an algorithm that automatically identifies high-susceptibility areas and excludes them from T(2) * measurements in the left ventricle (LV) for myocardial iron measurements. An autoregressive moving average (ARMA) model was implemented on multigradient echo scans of 24 patients (age range 3-45 years, 10 male/14 female). Voxels ...
Zoerle Tommaso - - 2013
Animal models have been developed to simulate angiographic vasospasm secondary to subarachnoid hemorrhage (SAH) and to test pharmacologic treatments. Our aim was to evaluate the effect of pharmacologic treatments that have been tested in humans and in preclinical studies to determine if animal models inform results reported in humans. A ...
Shao Yongni - - 2013
Two sensitive wavelength (SW) selection methods combined with visible/near infrared (Vis/NIR) spectroscopy were investigated to determine the levels of some trace elements (Fe, Zn) in rice leaf. A total of 90 samples were prepared for the calibration (n = 70) and validation (n = 20) sets. Calibration models using SWs ...
Fruciano Carmelo - - 2013
Modularity has been suggested to be connected to evolvability because a higher degree of independence among parts allows them to evolve as separate units. Recently, the Escoufier RV coefficient has been proposed as a measure of the degree of integration between modules in multivariate morphometric datasets. However, it has been ...
Sosnowski Maciej - - 2013
Multidetector computed tomography angiography (MDCT) can provide data regarding cardiac function if a retrospective scanning is applied. We aimed at examination of the reproducibility of traditional and more sensitive parameters of the left ventricular (LV) contractility by means of a 64-row CT in order to establish errors of measurement and ...
Sutter David A H - - 2012
Fisheries-induced evolution and its impact on the productivity of exploited fish stocks remains a highly contested research topic in applied fish evolution and fisheries science. Although many quantitative models assume that larger, more fecund fish are preferentially removed by fishing, there is no empirical evidence describing the relationship between vulnerability ...
de Paulo Jaqueline M - - 2012
This work presents a low cost system based on Flame Emission Spectroscopy (FES) that enables the prediction of fuel adulteration. The spectral data acquired using FES were associated with chemometric tools - Partial Least Squares Discriminant Analysis (PLS-DA) and Partial Least Squares (PLS), aiming to predict gasoline adulterations with different ...
Esquivelzeta C - - 2012
The aim of this study was to assess the accuracy of the ultrasound measurements for predicting carcass traits in 124 Spanish 'pascual'-type lambs (13 to 16 kg of carcass weight). Ultrasound images were taken transversal and longitudinal to the vertebral column, and at thoracic (TV; between 12th and 13th ribs) ...
Li Q - - 2012
In this work, we describe a beat-by-beat method for assessing the clinical utility of pulsatile waveforms, primarily recorded from cardiovascular blood volume or pressure changes, concentrating on the photoplethysmogram (PPG). Physiological blood flow is nonstationary, with pulses changing in height, width and morphology due to changes in heart rate, cardiac ...
Mitrophanov Alexander Y - - 2012
Prothrombin complex concentrates (PCCs), which contain different coagulation proteins, are attractive alternatives to the standard methods to treat dilution-induced (and, generally, traumatic) coagulopathy. We investigated the ability of a novel PCC composition to restore normal thrombin generation in diluted blood. The performance of the proposed PCC composition (coagulation factors [F] ...
Sikirzhytski Vitali - - 2012
Conventional confirmatory biochemical tests used in the forensic analysis of body fluid traces found at a crime scene are destructive and not universal. Recently, we reported on the application of near-infrared (NIR) Raman microspectroscopy for non-destructive confirmatory identification of pure blood, saliva, semen, vaginal fluid and sweat. Here we expand ...
Golmohammadi Hassan - - 2012
In the present study a quantitative structure-activity relationship (QSAR) technique was developed to investigate the blood-to-brain barrier partitioning behavior (log BB) for various drugs and organic compounds. Important descriptors were selected by genetic algorithm-partial least square (GA-PLS) methods. Partial least squares (PLS) and support vector machine (SVM) methods were employed ...
Nightingale M J - - 2012
BACKGROUND: Statistical process control (SPC) is used to monitor the performance of blood component collection and production processes in the UK and elsewhere. The sensitivity of the applied technique(s) needs to be matched to the clinical importance of the parameter being monitored such that significant deviations in the process mean ...
Heller Gillian Z - - 2012
Patients undergoing stem cell transplantation may require transfusion of units (bags) of packed red blood cells (PRBCs). Modelling of PRBC usage is important not only for prediction of transfusion requirements in future patients but also for its use as an inverse surrogate for engraftment, that is transplantation success. Inspection of ...
Chinta Lakshminarayan V - - 2012
Vascular transit time is an important indicator of microcirculatory health. We present a second-order-plus-dead-time (SOPDT) model for robust estimation of kinetic parameters characterizing microvascular bolus passage using two-photon fluorescence microscopy (2PFM) in anesthetized rats receiving somatosensory stimulation. This methodology enables quantification of transit time, time-to-peak, overshoot, and rate of bolus ...
Hisano Marcelo - - 2012
Abstract Introduction: Although the retroperitoneal approach has been the preferred choice for open urological procedures, retroperitoneoscopy is not the preferred approach for laparoscopy. This study aims to develop a training model for retroperitoneoscopy and to establish an experimental learning curve. Material and methods: Fifteen piglets were operated on to develop ...
Silva Ikaro - - 2012
A signal quality estimate of a physiological waveform can be an important initial step for automated processing of real-world data. This paper presents a new generic point-by-point signal quality index (SQI) based on adaptive multichannel prediction that does not rely on ad hoc morphological feature extraction from the target waveform. ...
Martín-Santana Josefa D - - 2012
This paper presents an explicative model on the recommendation of donating blood made to relatives and friends by current donors. This model establishes satisfaction and intention to return as direct antecedents, and the quality perceived in the donation process and the existence of inhibitors as indirect antecedents. The results show ...
Verner Marc-André - - 2012
BACKGROUND: Biomonitoring of chemicals in the workplace provides an integrated characterization of exposure that accounts for uptake through multiple pathways and physiological parameters influencing the toxicokinetics. OBJECTIVES: We used the case of styrene to i) determine the best times to sample venous blood and end-exhaled air, ii) characterize the inter-individual ...
Mann K G - - 2012
The ultimate teacher on human physiology is human pathology and the clinical trials aimed at its amelioration. However, the pathway between disease and cure most frequently arises from a reductionist approach. Perhaps no better illustration of this process is the history of the diagnosis and treatment of hemophilia A, which ...
Blake Glen Mervyn - - 2012
PURPOSE: We describe a semipopulation input function for evaluating bone plasma clearance from static and dynamic F-fluoride PET scans. METHODS: The semipopulation input function was derived by fitting an exponential curve to venous plasma measurements obtained 30-60 min after injection and adding a population residual curve representing the bolus peak ...
McCoy Alene T - - 2012
TK Modeler 1.0 is a Microsoft(®) Excel(®)-based pharmacokinetic (PK) modeling program created to aid in the design of toxicokinetic (TK) studies. TK Modeler 1.0 predicts the diurnal blood/plasma concentrations of a test material after single, multiple bolus or dietary dosing using known PK information. Fluctuations in blood/plasma concentrations based on ...
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