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Gunawardena Jeremy J Department of Systems Biology, Harvard Medical School, Boston, MA 02115 - - 2014
Informal models have always been used in biology to guide thinking and devise experiments. In recent years, formal mathematical models have also been widely introduced. It is sometimes suggested that formal models are inherently superior to informal ones and that biology should develop along the lines of physics or economics ...
Mikawa Shoma S Laboratory of Veterinary Internal Medicine II, School of Veterinary Medicine, Faculty of Veterinary Science, Nippon Veterinary and Life Science - - 2014
Pulmonary hypertension (PH) often occurs due to a left heart disease such as myxomatous mitral valve disease (MMVD) in dogs and is diagnosed using Doppler echocardiography and estimated pulmonary arterial pressure. Diagnosis of PH in dogs requires expertise in echocardiography: however, the examination for PH is difficult to perform in ...
Goddard Melissa A MA Department of Physiology and Pharmacology, School of Medicine, Wake Forest University, Winston-Salem, NC 27109, - - 2014
X-linked myotubular myopathy (XLMTM) is a fatal pediatric disease where affected boys display profound weakness of the skeletal muscles. Possible therapies are under development but robust outcome measures in animal models are required for effective translation to human patients. We established a naturally-occurring canine model, where XLMTM dogs display clinical ...
Ulhassan Waqar - - 2014
As healthcare often is studied in relation to operational rather than socio-technical aspects of Lean such as teamwork, the purpose of this paper is to explore how a Swedish hospital Lean intervention was related to changes in teamwork over time. Teamwork was measured with the Group Development Questionnaire (GDQ) employee ...
Zhang Li L Emergency Department, Shanghai Pulmonary Hospital, Tongji University School of Medicine, 507 Zheng Min Rd., Yangpu District, Shanghai 200433, China. - - 2014
In this study, an extrusion-spheronization method was applied successfully to fabricate propafenone hydrochloride (PPF) sustained-release pellets. Using scanning electron microscopy, it was shown that the PPF pellets had a mean size of approximately 950 µm with a spherical shape. The in vitro release profiles indicated that the release of PPF ...
Parsons Michele B MB Program in Population Biology, Ecology, and Evolution and Departments of Environmental Sciences and Environmental Health, Emory University, Atlanta, Georgia, United States of America; Division of Foodborne, Waterborne and Environmental Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of - - 2014
Domesticated animals are an important source of pathogens to endangered wildlife populations, especially when anthropogenic activities increase their overlap with humans and wildlife. Recent work in Tanzania reports the introduction of Cryptosporidium into wild chimpanzee populations and the increased risk of ape mortality associated with SIVcpz-Cryptosporidium co-infection. Here we describe ...
Cho Sun-Joo SJ Vanderbilt University, Nashville, USA, - - 2013
An additive multilevel item structure (AMIS) model with random residuals is proposed. The model includes multilevel latent regressions of item discrimination and item difficulty parameters on covariates at both item and item category levels with random residuals at both levels. The AMIS model is useful for explanation purposes and also ...
Lendle Samuel D SD Division of Biostatistics, UC Berkeley, 101 Haviland Hall, Berkeley, CA 94720, USA. - - 2013
To compare the performance of a targeted maximum likelihood estimator (TMLE) and a collaborative TMLE (CTMLE) to other estimators in a drug safety analysis, including a regression-based estimator, propensity score (PS)-based estimators, and an alternate doubly robust (DR) estimator in a real example and simulations. The real data set is ...
Cross Deanna S DS Center for Human Genetics, Marshfield Clinic Research Foundation, Marshfield, - - 2013
Emerging biomarkers for acute myocardial infarction (AMI) may enhance conventional risk-prediction algorithms if they are informative and associated with risk independently of established predictors. In this study, we constructed a cohort for testing emerging biomarkers for AMI in managed-care populations using existing biospecimen repositories linked to electronic health records (EHR). ...
Liang Zhenhu - - 2013
Objective. The dynamic change of brain activity in anesthesia is an interesting topic for clinical doctors and drug designers. To explore the dynamical features of brain activity in anesthesia, a permutation auto-mutual information (PAMI) method is proposed to measure the information coupling of electroencephalogram (EEG) time series obtained in anesthesia. ...
Scott Anne E AE Edinburgh Heart Centre, Little France Crescent, Edinburgh EH164TJ, UK. - - 2013
To examine the relative and combined value of late gadolinium enhancement (LGE) and low-dose dobutamine (LDD) cardiac magnetic resonance (CMR) to predict 'adverse remodelling' (AR) following acute myocardial infarction (AMI). Forty-five patients with AMI were recruited. CMR was performed 2-4 days after presentation and at 6 months. Ventricular wall motion ...
Noguero Adrián - - 2013
There is an increasing number of Ambient Intelligence (AmI) systems that are time-sensitive and resource-aware. From healthcare to building and even home/office automation, it is now common to find systems combining interactive and sensing multimedia traffic with relatively simple sensors and actuators (door locks, presence detectors, RFIDs, HVAC, information panels, ...
Wax Joseph R - - 2012
Because no simulation models are described for chorionic villus sampling (CVS), we sought to design and construct a CVS training simulator. Using materials available from our labor floor and local supermarket, we built and demonstrated a practical model for learning transabdominal and transcervical CVS. The simulator can be used to ...
dos Reis Mario - - 2012
The fossil record suggests a rapid radiation of placental mammals following the Cretaceous-Paleogene (K-Pg) mass extinction 65 million years ago (Ma); nevertheless, molecular time estimates, while highly variable, are generally much older. Early molecular studies suffer from inadequate dating methods, reliance on the molecular clock, and simplistic and over-confident interpretations ...
Li Jing - - 2012
Preeclampsia is defined as new-onset hypertension with proteinuria after 20 wk gestation and is hypothesized to be due to shallow trophoblast invasion in the spiral arteries thus resulting in progressive placental ischemia as the fetus grows. Many animal models have been developed that mimic changes in maternal circulation or immune ...
McWeeney Dennis T - - 2012
Objective Many fellowship programs in maternal-fetal medicine (MFM) lack sufficient exposure and training in chorionic villus sampling (CVS). We describe a novel training model of transabdominal and transcervical CVS.Methods A porcine heart simulated a 12-week human uterus with a cervical canal created at the apex of the heart. A piglet ...
Wanapirak Chanane - - 2012
Aim:  The aim of the present study was to establish Thai-specific reference ranges of triple markers for fetal Down syndrome as a function of gestational age as well as weight correction models and to compare the false positive rates when using Thai-specific model relative to Caucasian-specific model. Material and Methods:  ...
Desesso John M - - 2012
Anatomical and developmental differences of the parental-offspring interface among experimental animals and humans throughout gestation are reviewed focusing on biodistribution of immunoglobulins (IgG). The formation of the extraembryonic membranes, uteroplacental circulation, and characteristics of the placenta (gross shape, modes of implantation, surface modifications that increase surface area, and extent of ...
Mose T - - 2012
In the EU integrated project NewGeneris, we studied placental transport of thirteen immunotoxic and genotoxic agents in three ex vivo placental perfusion laboratories. In the present publication, all placental perfusion data have been re-analyzed and normalized to make them directly comparable and rankable. Antipyrine transfer data differed significantly between the ...
Goswami Anjali - - 2012
The timing of the placental mammal radiation has been a source of contention for decades. The fossil record of mammals extends over 200 million years, but no confirmed placental mammal fossils are known prior to 64 million years ago, which is approximately 1.5 million years after the Cretaceous-Paleogene (K-Pg) mass ...
Urzaiz Gabriel - - 2012
A solid and versatile communications platform is very important in modern Ambient Intelligence (AmI) applications, which usually require the transmission of large amounts of multimedia information over a highly heterogeneous network. This article focuses on the concept of Process-in-Network (PIN), which is defined as the possibility that the network processes ...
Miori Vittorio - - 2012
The key idea underlying many Ambient Intelligence (AmI) projects and applications is context awareness, which is based mainly on their capacity to identify users and their locations. The actual computing capacity should remain in the background, in the periphery of our awareness, and should only move to the center if ...
Modiri Arezoo A Electrical Engineering Department, University of Texas, Dallas, TX, USA. - - 2012
Global optimization algorithms basically create a set of solutions, classify them, and then search for the best answer, iteratively. In this paper, a new discrete particle swarm optimization algorithm is proposed to estimate the permittivity arrangements of lossy multilayer structures, which represent body tissue models. Microwave imaging (AMI) is the ...
Fox J Christian - - 2011
Incidental findings during ultrasound examinations occur frequently with live models in training sessions. Because of the broad scope of training sessions available, the ethics and guidelines of dealing with incidental findings in live models need to be discussed. We provide a case of an endovaginal ultrasound that had significant unexpected ...
Secko Michael A - - 2011
ACADEMIC EMERGENCY MEDICINE 2011; 18:1-4 © 2011 by the Society for Academic Emergency Medicine ABSTRACT: Objectives:  The authors determined if E-point septal separation (EPSS) as measured by junior emergency physicians (EPs) correlated with visual estimation of left ventricle ejection fraction (LVEF) by senior EPs and cardiologists in acutely dyspneic patients ...
Hung Shin-Yuan - - 2011
PURPOSE: Evidence-based medicine (EBM) supports physicians in their improvement of clinical quality and enhances hospitals' improvement of patient safety. Many health care institutions implement information systems to support physicians practicing EBM. However, studies exploring the antecedent factors of physicians' usage intention of information systems facilitating EBM practice are rare. Hence ...
Turner Shelly E - - 2011
This article explores the implementation of evidence-based design elements in the renovation of 1 patient room on a budget of $3500. The functional mock-up was evaluated through survey and focus groups by staff, visitors, and physicians to identify problematic features. Overall, participants perceived that design elements were effective with only ...
Ciaramitaro Palma - - 2011
Piemonte and Valle d'Aosta Interregional Network for Rare Diseases (RD) is a model of "diffuse" network; it involves all the health system specialists devoted to the diagnosis, the therapy and the follow-up of a RD. The Consortium is a multidisciplinary team operating throughout the Region composed of volunteer Physicians and ...
McLeod Logan - - 2011
Predicting health care utilization is the foundation of many health economics analyses, such as calculating risk-adjustment capitation payments or measuring equity in health care utilization. The most common econometric models of physician utilization are parametric count data models, since the most common metric of physician utilization is the number of ...
Orruño Estibalitz - - 2011
We examined the main factors affecting the intention of physicians to use teledermatology using a modified Technology Acceptance Model (TAM). The investigation was carried out during a teledermatology pilot study conducted in Spain. A total of 276 questionnaires were sent to physicians by email and 171 responded (62%). Cronbach's alpha ...
Zebrowitz Leslie A LA Brandeis - - 2011
Analogies between humans and animals based on facial resemblance have a long history. We report evidence for reverse anthropomorphism and the extension of facial stereotypes to lions, foxes, and dogs. In the stereotype extension, more positive traits were attributed to animals judged more attractive than con-specifics; more childlike traits were ...
Swift Arthur - - 2011
The recent availability of safe volumizing fillers has provided cosmetic physicians with the tools necessary to contour facial features non-surgically and cost-effectively. This review focuses on outlining objective parameters necessary for creating a template to maximize each individual's facial beauty. Phi relationships can be approached for all facial features and ...
Glaser Dale - - 2011
In population-based research, subjects are frequently in clusters with shared features or demographic characteristics, such as age range, neighborhood, who they have for a physician, and common comorbidities. Classification into clusters also applies at broader levels. Physicians are classified by physician group or by practice site; hospitals can be characterized ...
Planinac Lynn C - - 2011
We documented the extent of point-of-sale (POS) lottery promotions in Ontario, Canada and the relationship between lottery promotions and store and city characteristics. This is the first quantitative study of POS lottery promotions. A total of 366 stores-independent and chain convenience stores, gas stations and grocery stores-were visited across 20 ...
Quan Xiaojun - - 2011
Term weighting has proven to be an effective way to improve the performance of text categorization. Very recently, with the development of user-interactive question answering or community question answering, there has emerged a need to accurately categorize questions into predefined categories. However, as a question is usually a piece of ...
Shivakumara Palaiahnakote - - 2011
In this paper, we propose a method based on the Laplacian in the frequency domain for video text detection. Unlike many other approaches which assume that text is horizontally-oriented, our method is able to handle text of arbitrary orientation. The input image is first filtered with Fourier-Laplacian. K-means clustering is ...
Rubin Daniel L - - 2011
Radiologists frequently search the Web to find information they need to improve their practice, and knowing the types of information they seek could be useful for evaluating Web resources. Our goal was to develop an automated method to categorize unstructured user queries using a controlled terminology and to infer the ...
Kohl Michael - - 2011
Modeling is a means for integrating the results from Genomics, Transcriptomics, Proteomics, and Metabolomics experiments and for gaining insights into the interaction of the constituents of biological systems. However, sharing such large amounts of frequently heterogeneous and distributed experimental data needs both standard data formats and public repositories. Standardization and ...
Martens Lennart - - 2011
With the advent of more powerful and sensitive analytical techniques and instruments, the field of mass spectrometry based proteomics has seen a considerable increase in the amount of generated data. Correspondingly, the need to make these data publicly available in centralized online databases has also become more pressing. As a ...
Høstgaard Anna Marie - - 2011
Experience has shown that for new health-information-technology (HIT) to be suc-cessful clinicians must obtain positive clinical benefits as a result of its implementation and joint-ownership of the decisions made during the development process. A prerequisite for achieving both success criteria is real end-user-participation. Experience has also shown that further research ...
Archer Norm - - 2011
There is a major campaign involving large expenditures of public money to increase the adoption rate of electronic health record (EHR) systems in Canada. To maximize the chances of success in this effort, physician views on EHRs must be addressed, since user perceptions are key to successful implementation of technology ...
Cappelli Raffaele - - 2010
In this paper, we introduce the Minutia Cylinder-Code (MCC): a novel representation based on 3D data structures (called cylinders), built from minutiae distances and angles. The cylinders can be created starting from a subset of the mandatory features (minutiae position and direction) defined by standards like ISO/IEC 19794-2 (2005). Thanks ...
Deus Helena F HF Department of Bioinformatics and Computational Biology, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd., Unit 1410, Houston, TX 77230-1402, USA. - - 2010
The Cancer Genome Atlas (TCGA) is a multidisciplinary, multi-institutional effort to characterize several types of cancer. Datasets from biomedical domains such as TCGA present a particularly challenging task for those interested in dynamically aggregating its results because the data sources are typically both heterogeneous and distributed. The Linked Data best ...
Whitmore Lee - - 2011
The Protein Circular Dichroism Data Bank (PCDDB) is a public repository that archives and freely distributes circular dichroism (CD) and synchrotron radiation CD (SRCD) spectral data and their associated experimental metadata. All entries undergo validation and curation procedures to ensure completeness, consistency and quality of the data included. A web-based ...
Endo Toshinori - - 2011
The Ciona intestinalis protein database (CIPRO) is an integrated protein database for the tunicate species C. intestinalis. The database is unique in two respects: first, because of its phylogenetic position, Ciona is suitable model for understanding vertebrate evolution; and second, the database includes original large-scale transcriptomic and proteomic data. Ciona ...
Gardner Paul P - - 2011
The Rfam database aims to catalogue non-coding RNAs through the use of sequence alignments and statistical profile models known as covariance models. In this contribution, we discuss the pros and cons of using the online encyclopedia, Wikipedia, as a source of community-derived annotation. We discuss the addition of groupings of ...
Liu K K Department of Biomedical Informatics, UPMC Cancer Pavilion, Suite 301, 5150 Centre Avenue, Pittsburgh, PA 15232, USA. - - 2011
To evaluate the effectiveness of a lexico-syntactic pattern (LSP) matching method for ontology enrichment using clinical documents. Two domains were separately studied using the same methodology. We used radiology documents to enrich RadLex and pathology documents to enrich National Cancer Institute Thesaurus (NCIT). Several known LSPs were used for semantic ...
Ceusters W W New York State Center of Excellence in Bioinformatics & Life Sciences, 701 Ellicott Street, Buffalo, NY 14203, USA. - - 2011
Part of the ReMINE project involved the creation of an ontology enabling computer-assisted decision support for optimal adverse event management. The ontology was required to satisfy the following requirements: 1) to be able to account for the distinct and context-dependent ways in which authoritative sources define the term 'adverse event', ...
Maroto-Molina F - - 2011
Information about the nutritional aspects and uses of feed is of widespread interest, hence systematic efforts of laboratories to obtain it. The way this information is currently being handled leaves something to be desired, underscoring the need to use computerized systems and statistical techniques that allow the management of large ...
Marko Nicholas F - - 2010
The amount of available molecular biological data has increased by several orders of magnitude over the past decades, and the quality and accessibility of these data continue to improve exponentially. The ensuing shift toward the "large-p, small-n" paradigm holds great promise for medical discovery, but it also presents unique analytic ...
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