This paper presents RDFBuilder, a tool that enables RDF-based access to MAGE-ML-compliant microarray databases. We have developed a system that automatically transforms the MAGE-OM model and microarray data stored in the ArrayExpress database into RDF format. Additionally, the system automatically enables a SPARQL endpoint. This allows users to execute SPARQL ...

A paper sliceform or lattice-style pop-up is a form of papercraft that uses two sets of parallel paper patches slotted together to make a foldable structure. The structure can be folded flat, as well as fully opened (popped-up) to make the two sets of patches orthogonal to each other. Automatic ...

Objective. During transcranial electrical stimulation, current passage across the scalp generates voltage across the scalp surface. The goal was to characterize these scalp voltages for the purpose of validating subject-specific finite element method (FEM) models of current flow. Approach. Using a recording electrode array, we mapped skin voltages resulting from ...

The current planning guidance in London requires that all new or refurnished large buildings should include 20% renewables. As part of a study on urban wind a pilot investigation based on the building integrated wind turbines on the skyscraper Strata Tower in London will be monitored for acoustics, vibration, anemometry ...

Currently, according to conventional charge-discharge profiles, energy consumed in charging Capacitive Deionization (CDI) systems is always a function of different parameters (current used for charging, capacitance and current employed for discharging) making it difficult to separate the effect of these parameters on CDI performance and energy efficiency. Thus, energy efficiencies ...

RATIONALE AND OBJECTIVES: Based on imaging features, the optimal thresholds are typically determined as cutoff points to dichotomize the corresponding measurement scales. MATERIALS AND METHODS: Five metrics (ie, the Youden index, Euclidian distance, percent of correct diagnosis, kappa statistic, and mutual information) are individually maximized or minimized to derive the ...

This pilot study details the use of a software tool that uses continuous impedance measurement during electrode insertion, with the eventual potential to assess and optimize electrode position and reduce insertional trauma. Software development and experimental study with human cadaveric cochleae and two live surgeries. A prototype program to measure ...

In the present article, statistical properties regarding the topology and standard percolation on relative neighborhood graphs (RNGs) for planar sets of points, considering the Euclidean metric, are put under scrutiny. RNGs belong to the family of "proximity graphs"; i.e., their edgeset encodes proximity information regarding the close neighbors for the ...

We discuss a new method to determine the value of a decision threshold that can be used to decide whether to choose a one-sided confidence interval or a two-sided confidence interval. The method is based on the Feldman-Cousins unified approach providing a unique confidence region for estimated parameters. We apply ...

Object Precise localization of subdural electrodes (SDEs) is essential for the interpretation of data from intracranial electrocorticography recordings. Blood and fluid accumulation underneath the craniotomy flap leads to a nonlinear deformation of the brain surface and of the SDE array on postoperative CT scans and adversely impacts the accurate localization ...

A new parameterization scheme of DFT-D is proposed with the aim of devising a methodology for the study of graphitic material. The main feature of the new system is the geometry optimization within the fitting scheme. The DFT-D parameters are obtained for the benzene dimer, a good model molecule for ...

The evolution of healthcare towards evidence driven decision-making has been facilitated by electronic data management and the development of large clinical databases. As previously described (1), the American College of Cardiology Foundation (ACCF; www.acc.org), through its subsidiary the National Cardiovascular Data Registry ® (NCDR; www.accncdr.com) worked in collaboration with Heart ...

OBJECTIVES: Automated external defibrillators (AEDs) are lifesaving, but little is known about where they are located or how to find them. We sought to locate AEDs in high employment areas of Philadelphia and characterize the process of door-to-door surveying to identify these devices. METHODS: Block groups representing approximately the top ...

Abstract This study reports the empirical analysis of a hyper-heuristic evolutionary algorithm that is capable of automatically designing top-down decision-tree induction algorithms. Top-down decision-tree algorithms are of great importance, considering their ability of providing an intuitive and accurate knowledge representation for classification problems. The automatic design of these algorithms seems ...

Pulsed Gradient Spin Echo (PGSE) is a well-known NMR technique for determination of diffusion coefficients. Various signal processing techniques have been introduced to solve the task, which is especially challenging when the decay is multi-exponential with unknown number of components. Here, we introduce a new method for processing of such ...

We study the fidelity of the surface code in the presence of correlated errors induced by the coupling of physical qubits to a bosonic environment. By mapping the time evolution of the system after one quantum error correction cycle onto a statistical spin model, we show that the existence of ...

Identifying persistence and extinction thresholds in species-habitat relationships is a major focal point of ecological research and conservation. However, one major concern regarding the incorporation of threshold analyses in conservation is the lack of knowledge on the generality and transferability of results across species and regions. We present a multi-region, ...

Graph theory deterministically models networks as sets of vertices, which are linked by connections. Such mathematical representation of networks, called graphs are increasingly used in neuroscience to model functional brain networks. It was shown that many forms of structural and functional brain networks have small-world characteristics, thus, constitute networks of ...

Since mean-field approximations for susceptible-infected-susceptible (SIS) epidemics do not always predict the correct scaling of the epidemic threshold of the SIS metastable regime, we propose two novel approaches: (a) an ɛ-SIS generalized model and (b) a modified SIS model that prevents the epidemic from dying out (i.e., without the complicating ...

Brain-machine interfaces (BMIs) can translate the neuronal activity underlying a user's movement intention into movements of an artificial effector. In spite of continuous improvements, errors in movement decoding are still a major problem of current BMI systems. If the difference between the decoded and intended movements becomes noticeable, it may ...

Theoretical models predict that drylands can cross critical thresholds, but experimental manipulations to evaluate them are non-existent. We used a long-term (13-year) pulse-perturbation experiment featuring heavy grazing and shrub removal to determine if critical thresholds and their determinants can be demonstrated in Chihuahuan Desert grasslands. We asked if cover values ...

Biphasic contact analysis is essential to obtain a complete understanding of soft tissue biomechanics, and the importance of physiological structure on the joint biomechanics has long been recognised; however, up to date, there are no successful developments of biphasic finite element contact analysis for three-dimensional (3D) geometries of physiological joints. ...

Estimation of on-off timing of human skeletal muscles during movement is an ongoing issue in surface electromyography (sEMG) signal processing for relevant clinical applications. Widely used single threshold methods still rely on the experience of the operator to manually establish a threshold level. In this paper, a novel approach to ...

Estimation of genomic breeding values is the key step in genomic selection (GS). Many methods have been proposed for continuous traits, but methods for threshold traits are still scarce. Here we introduced threshold model to the framework of GS, and specifically, we extended the three Bayesian methods BayesA, BayesB and ...

A study deriving a threshold for moderate- to vigorous-intensity physical activity (MVPA) in terms of accelerometer counts in 12-year-old children was repeated with a subset of the same children at 16 years. Fifteen girls and thirty boys took part in 6 activities (lying, sitting, slow walking, walking, hopscotch and jogging) ...

To assess how different diagnostic decision aids perform in terms of sensitivity, specificity, and harm. Four diagnostic decision aids were compared, as applied to a simulated patient population: a findings-based algorithm following a linear or branched pathway, a serial threshold-based strategy, and a parallel threshold-based strategy. Headache in immune-compromised HIV ...

An algorithm is presented for error correction in the surface code quantum memory. This is shown to correct depolarizing noise up to a threshold error rate of 18.5%, exceeding previous results and coming close to the upper bound of 18.9%. The time complexity of the algorithm is found to be ...

ABSTRACT: BACKGROUND: Ventricular Fibrillation (VF) is a common presenting dysrhythmia in the setting of cardiac arrest whose main treatment is defibrillation through direct current countershock to achieve return of spontaneous circulation. However, often defibrillation is unsuccessful and may even lead to the transition of VF to more nefarious rhythms such ...

The response of nanoscale electrodes displays deviations from conventional voltammetry theory that include a reduction in the limiting current and enhanced current fluctuations. We study the power spectra of these fluctuations in well characterized conical electrodes with radii between 2 and 10 nm. The fluctuations are found to display non-trivial ...

In this paper, we examine the effects of recent parental Medicaid eligibility expansions on Medicaid participation and private insurance coverage. We present a new approach for estimating these policy effects that explicitly models the particular policy instrument over which legislators have control-income eligibility thresholds. Our approach circumvents estimation problems stemming ...

OBJECTIVE: Though tDCS is well tolerated, it is desirable to further limit the voltage applied for additional safety factors and optimized device design. We investigated the minimum voltage required for tDCS using 1.5 and 2.5mA. METHODS: Impedance data has been collected prior to, during and after 18 tDCS sessions, using ...

OBJECTIVE: The evidence that monophasic defibrillation success is mainly determined by current is secure. However, modern defibrillators use biphasic waveforms. The aim of this study was to compare energy, peak voltage and peak current in predicting biphasic shock success in a porcine model of ventricular fibrillation (VF) where the impedance ...

Objective: Non-random missing data can adversely affect family-based linkage detection through loss of power and possible introduction of bias depending on how censoring is modeled. We examined the statistical properties of a previously proposed quantitative trait threshold (QTT) model developed for when censored data can be reasonably inferred to be ...

In underwater environment, the platform uses active sonar to estimate the range to the target, covertly. The target employs detectors designed to find anomalies in its ambient environment, including man-made waveforms such as ones transmitted by the platform. However, the structure of the waveform is unknown. In this scenario, we ...

Objectives: The International Classification of Diseases and Related Health Problems, 10th Revision, Thai Modification (ICD-10-TM) ontology is a knowledge base created from the Thai modification of the World Health Organization International Classification of Diseases and Related Health Problems, 10th Revision. The objectives of this research were to develop the ICD-10-TM ...

The brain is in a constant state of dynamic change, for example switching between cognitive and behavioural tasks, and between wakefulness and sleep. The brains of people with epilepsy have additional features to their dynamic repertoire, particularly the paroxysmal occurrence of seizures. Substantial effort over decades has produced a detailed ...

Background: Structural magnetic resonance imaging (MRI) of the brain could be a powerful tool for discovering early biomarkers in clinically presymptomatic carriers of the Huntington's disease gene mutation (preHD). So far, structural changes have been found mainly in preHD approaching the estimated motor onset of the disease (i.e. less than ...

Establishing accurate mathematical models of outcome measures is essential in understanding change throughout the rehabilitation and recovery process. The goal of this study is to identify the best fitting descriptive models for a set of commonly adopted outcome measures found within the Traumatic Brain Injury Model Systems National Database where ...

The resolution of multidimensional NMR spectra can be severely limited when regular sampling based on the Nyquist-Shannon theorem is used. The theorem binds the sampling rate with a bandwidth of a sampled signal and thus implicitly creates a dependence between the line width and the time of experiment, often making ...

An accurate means of predicting blood-brain barrier (BBB) penetration and blood-brain partitioning of NCEs (new chemical entities) would fulfill a major need in pharmaceutical research. Currently, an industry-standard BBB drug penetration model is not available. Primary brain capillary endothelial cells, optionally co-cultured with astrocytes and/or pericytes, are the most valued ...

Accidental electrocutions kill about 1000 individuals annually in the USA alone. There has not been a systematic review or modeling of elapsed time duration defibrillation success rates following electrically-induced VF. With such a model, there may be an opportunity to improve the outcomes for industrial electrocutions and further understand arrest-related-deaths ...

This article presents the integration of brain injury biomechanics and graph theoretical analysis of neuronal connections, or connectomics, to form a neurocomputational model that captures spatiotemporal characteristics of trauma. We relate localized mechanical brain damage predicted from biofidelic finite element simulations of the human head subjected to impact with degradation ...

The objectives of this study were to quantify the errors in economic values (EVs) for traits affected by cost or price thresholds when skewed or kurtotic distributions of varying degree are assumed to be normal and when data with a normal distribution is subject to censoring. EVs were estimated for ...

In this paper we show advantages of using an advanced montage scheme with respect to the performance of automatic seizure detection systems. The main goal is to find the best performing montage scheme for our automatic seizure detection system. The new virtual montage is a fix set of dipoles within ...

Targeted transcranial stimulation with electric currents requires accurate models of the current flow from scalp electrodes to the human brain. Idiosyncratic anatomy of individual brains and heads leads to significant variability in such current flows across subjects, thus, necessitating accurate individualized head models. Here we report on an automated processing ...

Contemporary cochlear implants stimulate the auditory nerve with an array of up to 22 electrodes. More electrodes do not typically provide improved hearing performance. Given that this limitation is primarily due to current spread, and that newly developing kinds of electrodes may enable more focused stimulation, we recently proposed an ...

Inspired by the extraordinary object grabbing ability of certain insects (e.g., a grasshopper), we have developed a novel dry EEG electrode, called the skin screw electrode. Unlike the traditional disc electrode which requires several minutes to install, the installation of the skin screw electrode can be completed within seconds since ...

OBJECTIVE: The aim of this study was to develop a method to predict a tracer's α-value in the human brain on the basis of animal data. The α-value is the ratio of the conversion rate and the back-diffusion rate (k3/k2) and is one of the critical kinetic features of the ...

This off-line study aims to assess the performance of five classifiers commonly used in the brain-computer interface (BCI) community, when applied to a gaze-independent P300-based BCI. In particular, we compared the results of four linear classifiers and one nonlinear: Fisher's linear discriminant analysis (LDA), stepwise linear discriminant analysis (SWLDA), Bayesian ...

During treatment with deep brain stimulation (DBS), electrical current is delivered into the brain parenchyma through implanted electrodes. Although this technique is routinely used in the treatment of Parkinson's disease, essential tremor, and dystonia, a growing number of neuropsychiatric applications for DBS are being investigated. Investigators can use animal models ...