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Wang Rui R European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SD, - - 2014
Recent advances in high-throughput experimental techniques have led to an exponential increase in both the size and the complexity of the datasets commonly studied in biology. Data visualisation is increasingly used as the key to unlock this data, going from hypothesis generation to model evaluation and tool implementation. It is ...
Gutjahr Fabian T FT Universität Würzburg, Lehrstuhl für Experimentelle Physik 5, Am Hubland, 97074, Würzburg, Germany; Comprehensive Heart Failure Center, Core Facility Imaging, Straubmühlweg 2a, 97078, Würzburg, - - 2014
A method for the quantification of perfusion in murine myocardium is demonstrated. The method allows for the reconstruction of perfusion maps on arbitrary time points in the heart cycle while addressing problems that arise due to the irregular heart beat of mice. A flow-sensitive alternating inversion recovery arterial spin labeling ...
Jouffre Stéphane S CeRCA, UMR CNRS 7295, Université de Poitiers, France - - 2014
Individuals attempting to label their emotions look for a plausible source of their physiological arousal. Co-occurrence of plausible sources can lead to the misattribution of real (or bogus) physiological arousal, resulting in physically attractive individuals being perceived as more attractive than they actually are. In two experiments, female participants heard ...
Wander J D JD Microsoft Research, One Microsoft way, Redmond, WA 98052, USA. Department of Bioengineering, University of Washington, 3720 15th Ave NE, Seattle, WA 98105, - - 2014
Continuous cardiac monitoring of healthy and unhealthy patients can help us understand the progression of heart disease and enable early treatment. Optical pulse sensing is an excellent candidate for continuous mobile monitoring of cardiovascular health indicators, but optical pulse signals are susceptible to corruption from a number of noise sources, ...
Talbot Denis D Département de mathématiques, Université du Québec à Montréal, Montréal, Canada; Département de médecine sociale et préventive, Université Laval, Québec, - - 2014
Marginal structural models are commonly used to estimate the causal effect of a time-varying treatment in presence of time-dependent confounding. When fitting an MSM to data, the analyst must specify both the structural model for the outcome and the treatment models for the inverse-probability-of-treatment weights. The use of stabilized weights ...
Marzbanrad Faezeh - - 2014
Electromechanical coupling of the fetal heart can be evaluated non-invasively using Doppler Ultrasound (DUS) signal and fetal electrocardiography (fECG). In this study, an efficient model is proposed using K-means clustering and hybrid SVM-HMM modeling techniques. Opening and closing of the cardiac valves were detected from peaks in the high frequency ...
De Almeida M C MC Instituto de Biologia-Genética e Morfologia, Universidade de Brasília, Campus Universitário Darcy Ribeiro, Brasília, DF, CEP 70910-900, Brazil, - - 2014
The Purkinje network is not macroscopically visible in human hearts. Sunao Tawara found himself in trouble in the early 1900s, when studying the human heart network. He gained a much better understanding of the net after starting to work with ungulates' hearts. The ungulate heart is proposed as an auxiliary ...
Young Andrew A Department of Biomedical Engineering, University of Strathclyde, Glasgow, Scotland, UK; Department of Mathematics and Statistics, University of Strathclyde, Glasgow, Scotland, - - 2014
Previous studies have employed generic 3D-multiscale models to predict haemodynamic effects of the hybrid procedure in hypoplastic left heart syndrome. Patient-specific models, derived from image data, may allow a more clinically relevant model. However, such models require long computation times and employ internal pulmonary artery band [dint] dimension, which limits ...
Rodius Sophie - - 2014
Zebrafish is a clinically-relevant model of heart regeneration. Unlike mammals, it has a remarkable heart repair capacity after injury, and promises novel translational applications. Amputation and cryoinjury models are key research tools for understanding injury response and regeneration in vivo. An understanding of the transcriptional responses following injury is needed ...
Zaylaa Amira A Department of Medical Biophysics and Imaging, Signal-Imaging Group, Team-5 of UMR 930, François-Rabelais University of Tours, 7 Avenue Marcel Dassault, 37200 Tours Cedex, France; Department of Physics and Electronics, Faculty of Sciences, Lebanese University, Beirut, Lebanon. Electronic address: - - 2014
The analysis of biomedical signals demonstrating complexity through recurrence plots is challenging. Quantification of recurrences is often biased by sojourn points that hide dynamic transitions. To overcome this problem, time series have previously been embedded at high dimensions. However, no one has quantified the elimination of sojourn points and rate ...
Uccella S S Department of Obstetrics and Gynaecology, University of Insubria, Del Ponte Hospital , Varese , - - 2014
Our aim has been to investigate the accuracy in predicting intrapartum fetal acidaemia and the interobserver reproducibility of a mathematical algorithm for the interpretation of electronic fetal heart rate (FHR) monitoring throughout labour. Eight physicians (blinded to the clinical outcomes of the deliveries) evaluated four randomly selected intrapartum FHR tracings ...
Boukens Bastiaan J BJ Department of Biomedical Engineering, Washington University, St Louis - - 2014
The ECG is a primary diagnostic tool in patients suffering from heart disease, underscoring the importance of understanding factors contributing to normal and abnormal electrical patterns. Over the past few decades, transgenic mouse models are increasingly used to study pathophysiological mechanisms of human heart diseases. In order to allow extrapolation ...
Skotte Jørgen H - - 2014
Heart rate variability (HRV) analysis, which is an important tool for activity assessment of the cardiac autonomic nervous system, very often includes the estimation of power spectra for series of interbeat intervals (IBI). Ectopic beats and artifacts have a destructive effect on the standard methods (Fourier transform, FFT) for frequency ...
Lian Xiaojun X Department of Cell and Molecular Biology, Karolinska Institutet, Solna 17177, - - 2014
Cardiogenesis is one of the earliest and most important steps during human development and is orchestrated by discrete families of heart progenitors, which build distinct regions of the fetal heart. For the past decade, a lineage map for the distinct subsets of progenitors that generate the embryonic mammalian heart has ...
Henriques Jorge - - 2014
This work aims to assess the predictive value of physiological data daily collected in a telemonitoring study in the early detection of heart failure decompensation events. The main hypothesis is that physiological time series with similar progression (trends) may have prognostic value in future clinical states (decompensation or normal condition). ...
Horgan S S UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland; Non-invasive Cardiovascular Imaging, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA. Electronic address: - - 2014
Left ventricular diastolic dysfunction leads to heart failure with preserved ejection fraction, an increasingly prevalent condition largely driven by modern day lifestyle risk factors. As heart failure with preserved ejection fraction accounts for nearly half of all patients with heart failure, appropriate animal models are required to improve our understanding ...
Devanne Maxime - - 2014
Recognizing human actions in 3-D video sequences is an important open problem that is currently at the heart of many research domains including surveillance, natural interfaces and rehabilitation. However, the design and development of models for action recognition that are both accurate and efficient is a challenging task due to ...
Gopakumar Shivapratap - - 2014
We investigate feature stability in the context of clinical prognosis derived from high-dimensional Electronic Medical Records. To reduce variance in the selected features that are predictive, we introduce Laplacian-based regularization into a regression model. The Laplacian is derived on a feature graph that captures both the temporal and hierarchic relations ...
de Schlichting E E Ladaf, Laboratoire d'Anatomie des Alpes Françaises, UFR de Médecine, Université Grenoble-Alpes, Domaine de la Merci, 38706, La Tronche Cedex, - - 2014
The 3D modeling of human anatomy is more and more often used in medical education and in computer-augmented medicine. The lack of a 3D model of the pericardium has led us to its implementation. The pericardium was reconstructed from a CT scan recording of a young, healthy subject. The anonymous ...
Ouwerkerk Wouter W Department of Clinical Epidemiology, Biostatistics, and Bioinformatics, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands. Electronic address: - - 2014
The present paper systematically reviews and compares existing prediction models in order to establish the strongest variables, models, and model characteristics in patients with heart failure predicting outcome. To improve decision making accurately predicting mortality and heart-failure hospitalization in patients with heart failure can be important for selecting patients with ...
Rahimi Kazem K George Institute for Global Health, University of Oxford, Oxford, United Kingdom; Division of Cardiovascular Medicine, University of Oxford, Oxford, United Kingdom; Department of Cardiology, Oxford University Hospitals NHS Trust, Oxford, United Kingdom. Electronic address: - - 2014
This study sought to review the literature for risk prediction models in patients with heart failure and to identify the most consistently reported independent predictors of risk across models. Risk assessment provides information about patient prognosis, guides decision making about the type and intensity of care, and enables better understanding ...
Pope Katherine S KS Department of Plant Sciences, University of California, 70 Cottonwood Street, Davis, CA, 95695, USA, - - 2014
Warming winters due to climate change may critically affect temperate tree species. Insufficiently cold winters are thought to result in fewer viable flower buds and the subsequent development of fewer fruits or nuts, decreasing the yield of an orchard or fecundity of a species. The best existing approximation for a ...
Berger Ryan R a Florida State University College of Medicine , Tallahassee - - 2014
Abstract. The use of AEDs increases survival in cardiac arrest events. Due to the success of previous efforts and free, readily available mobile mapping software, the discussion is to emphasize the importance of the use of AEDs to prevent SCA-related deaths on college campuses and abroad, while suggesting a novel ...
Starke Verena V Carnegie Institution of Washington, Geophysical Laboratory, 5251 Broad Branch Road, Washington, DC 20015, USA - - 2014
This paper presents Thresher, an improved technique for finding peak height thresholds for ARISA profiles. We argue that thresholds must be sample dependent, taking community richness into account. In most previous fragment analyses, a common threshold is applied to all samples simultaneously, ignoring richness variations among samples and thereby compromising ...
Green H K HK Respiratory Diseases Department, Centre for Infectious Disease Surveillance and Control, Public Health England, - - 2014
SUMMARY General Practitioner consultation rates for influenza-like illness (ILI) are monitored through several geographically distinct schemes in the UK, providing early warning to government and health services of community circulation and intensity of activity each winter. Following on from the 2009 pandemic, there has been a harmonization initiative to allow ...
Sohrabpour Abbas A Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN, - - 2014
To investigate the relationship between EEG source localization and the number of scalp EEG recording channels. 128 EEG channel recordings of 5 pediatric patients with medically intractable partial epilepsy were used to perform source localization of interictal spikes. The results were compared with surgical resection and intracranial recordings. Various electrode ...
Chen Bihua B School of Biomedical Engineering, Third Military Medical University and Chongqing University, Chongqing, - - 2014
Defibrillation current has been shown to be a clinically more relevant dosing unit than energy. However, the effects of average and peak current in determining shock outcome are still undetermined. The aim of this study was to investigate the relationship between average current, peak current and defibrillation success when different ...
Lemkin Daniel L DL From the Department of Emergency Medicine, University of Maryland School of Medicine (D.L.L., M.D.W, A.F., M.C.B.), Department of Emergency Medicine, University of Maryland Medical Center (M.A.), Baltimore, MD, and Linear Technology (M.L.), Hayward, CA. Electronic address: - - 2014
The use of hands-on defibrillation (HOD) to reduce interruption of chest compression after cardiac arrest has been suggested as a means of improving resuscitation outcomes. The potential dangers of this strategy in regard to exposing rescuers to electrical energy are still being debated. This study seeks to determine the plausible ...
Cabello Gema G Instituto de Química Física "Rocasolano", CSIC, C. Serrano 119, E-28006, Madrid, - - 2014
The shift with increasing concentration of alkali-metal cations of the potentials of both the spike and the hump observed in the cyclic voltammograms of Pt(111) electrodes in sulfuric acid solutions is shown to obey the simple model recently developed by us to explain the effect of non-covalent interactions at the ...
Huig Isabelle C IC Erasmus Medical Centre, Rotterdam, Netherlands. Electronic address: - - 2014
In the Netherlands there are, at the time of writing, no clear guidelines about the implementation of automated external defibrillators (AEDs). An observational study was conducted to investigate the current status of AEDs in city centres in the Netherlands looking specifically at the availability, condition and employability of the AEDs. ...
Piray Payam P Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, 6500 HB Nijmegen, the Netherlands, p.piray@donders.ru.nl - - 2014
A substantial subset of Parkinson's disease (PD) patients suffers from impulse control disorders (ICDs), which are side effects of dopaminergic medication. Dopamine plays a key role in reinforcement learning processes. One class of reinforcement learning models, known as the actor-critic model, suggests that two components are involved in these reinforcement ...
Backlund Ville-Pekka VP BECS, School of Science, Aalto University, P.O. Box 12200, FI-00076 AALTO, - - 2014
A person's decision to adopt an idea or product is often driven by the decisions of peers, mediated through a network of social ties. A common way of modeling adoption dynamics is to use threshold models, where a node may become an adopter given a high enough rate of contacts ...
Farooq Adnan A Impedance Imaging Research Center and Department of Biomedical Engineering, Kyung Hee University, - - 2014
Electrical impedance tomography is an attractive functional imaging method. It is currently limited in resolution and sensitivity due to the complexity of the inverse problem and the safety limits of introducing current. Recently, internal electrodes have been proposed for some clinical situations such as intensive care or RF ablation. This ...
Griffanti L L Ludovica Griffanti, MR Laboratory, Fondazione Don Carlo Gnocchi ONLUS, IRCCS S. Maria Nascente, via Capecelatro 66, 20148 Milan, Italy, E-mail: - - 2014
Introduction: This article is part of the Focus Theme of Methods of Information in Medicine on "Biosignal Interpretation: Advanced Methods for Neural Signals and Images". Background: Voxel-based functional connectivity analysis is a common method for resting state fMRI data. However, correlations between the seed and other brain voxels are corrupted ...
Wetzel Eunike E Otto-Friedrich-University Bamberg, - - 2014
When questionnaire data with an ordered polytomous response format are analyzed in the framework of item response theory using the partial credit model or the generalized partial credit model, reversed thresholds may occur. This led to the discussion of whether reversed thresholds violate model assumptions and indicate disordering of the ...
Jing X X Xia Jing, Assistant Professor, NIH Clinical Center, National Institutes of Health, Street, Bethesda,MA, - - 2014
Objectives: Graphical displays can make data more understandable; however, large graphs can challenge human comprehension. We have previously described a filtering method to provide high-level summary views of large data sets. In this paper we demonstrate our method for setting and selecting thresholds to limit graph size while retaining important ...
Elliott N C - - 2014
Panicle caterpillars comprise an economically important insect pest complex of sorghum throughout the Great Plains of the United States, particularly in Kansas, Oklahoma, and Texas. The sorghum panicle caterpillar complex consists of larvae of two polyphagous lepidopteran species: the corn earworm, Helicoverpa zea (Boddie), and fall armyworm, Spodoptera frugiperda (J.E. ...
Hsu Yung-Fong YF Department of Psychology, National Taiwan University, Taipei City, - - 2014
The study of thresholds for discriminability has been of long-standing interest in psychophysics. While threshold theories embrace the concept of discrete-state thresholds, signal detection theory discounts such a concept. In this paper we concern ourselves with the concept of thresholds from the discrete-state modelling viewpoint. In doing so, we find ...
Glick Joshua J Penn State Hershey Medical Center, Penn State College of Medicine, Hershey, - - 2014
Coordination of the tasks of performing chest compressions and defibrillation can lead to communication challenges that may prolong time spent off the chest. The purpose of this study was to determine whether defibrillation provided by the provider performing chest compressions led to a decrease in peri-shock pauses as compared to ...
Kempe René R Department of Biomedical Engineering, City College of the City University of New York, New York, NY 10031, USA. Department of Biomedical Engineering, Hamburg University of Applied Sciences, Hamburg, - - 2014
Objective. Research studies on transcranial electric stimulation, including direct current, often use a computational model to provide guidance on the placing of sponge-electrode pads. However, the expertise and computational resources needed for finite element modeling (FEM) make modeling impractical in a clinical setting. Our objective is to make the exploration ...
Wang Zhen Z Department of Physics, Hong Kong Baptist University, Kowloon Tong, Hong Kong; Center for Nonlinear Studies and Beijing-Hong Kong-Singapore Joint Center for Nonlinear and Complex systems, Institute of Computational and Theoretical Studies, Hong Kong Baptist University, Kowloon Tong, Hong - - 2014
Evolution of cooperation in the prisoner's dilemma and the public goods game is studied, where initially players belong to two independent structured populations. Simultaneously with the strategy evolution, players whose current utility exceeds a threshold are rewarded by an external link to a player belonging to the other population. Yet ...
Jahanmiri-Nezhad Faezeh F *Sensory Motor Performance Program, Rehabilitation Institute of Chicago, Illinois, U.S.A.; †Department of Bioengineering, University of Illinois, Chicago, Illinois, U.S.A.; ‡Department of Neurology, Medical College of Wisconsin, Milwaukee, Wisconsin, U.S.A.; §Department of Physical Medicine and Rehabilitation, Northwestern University, Chicago, Illinois, U.S.A.; and ‖Institute of Biomedical Engineering, University of Science and Technology of China, Hefei, - - 2014
Examination of spontaneous muscle activity is an important part of the routine electromyogram (EMG) in assessing neuromuscular diseases. The EMG is specifically valuable as a diagnostic test in supporting the diagnosis of amyotrophic lateral sclerosis. High-density surface EMG is a relatively new technique that has until now been used in ...
Cavanaugh Kyle C - - 2014
The manner in which patches are delineated in spatially realistic metapopulation models will influence the size, connectivity, and extinction and recolonization dynamics of those patches. Most commonly used patch-definition methods focus on identifying discrete, contiguous patches of habitat from a single temporal observation of species occurrence or from a model ...
Santos-Concejero Jordan J a UCT/MRC Research Unit for Exercise Science and Sports Medicine , University of Cape Town , Cape Town , South - - 2014
Abstract This study investigated the influence of the regression model and initial intensity during an incremental test on the relationship between the lactate threshold estimated by the maximal-deviation method and performance in elite-standard runners. Twenty-three well-trained runners completed a discontinuous incremental running test on a treadmill. Speed started at 9 ...
Chizhov A V AV A.F. Ioffe Physical-Technical Institute of the Russian Academy of Sciences, Politekhnicheskaya str., 26, 194021, Saint-Petersburg, Russia, - - 2014
Characteristics of action potential generation are important to understanding brain functioning and, thus, must be understood and modeled. It is still an open question what model can describe concurrently the phenomena of sharp spike shape, the spike threshold variability, and the divisive effect of shunting on the gain of frequency-current ...
Hirschfeld Gerrit G German Pediatric Pain Center, Children's Hospital, Dr.-Friedrich-Steiner Str. 5, 45711 Datteln, Germany; Children's Pain Therapy and Paediatric Palliative Care, Witten/Herdecke University, 45711 Datteln, Germany. Electronic address: - - 2014
Many diagnostic studies are aimed at defining "optimal" thresholds. Here, we evaluate the performance of empirically defined optimal thresholds (1) in the sample in which they were defined and (2) in the population from which the sample was drawn. We simulated test results for 120,000 samples varying the number of ...
Ashworth Allan A Atkins, Woodcote Grove, Ashley Road, Epsom, Surrey KT18 5BW, - - 2014
A new radioactive substances regulatory regime came into effect across the UK on 1 October 2011, accompanied by Government and regulator's guidance. The legislation sets new activity thresholds for what is within its scope and for what is exempt from the permitting requirements. These thresholds are, for the first time, ...
Rich Carly C Medical Research Centre of Epidemiology for Child Health, University College London, London, United - - 2014
Accelerometers are designed to measure plausible human activity, however extremely high count values (EHCV) have been recorded in large-scale studies. Using population data, we develop methodological principles for establishing an EHCV threshold, propose a threshold to define EHCV in the ActiGraph GT1M, determine occurrences of EHCV in a large-scale study, ...
Woo Choong-Wan CW Department of Psychology and Neuroscience, University of Colorado Boulder, USA; Institute of Cognitive Science, University of Colorado Boulder, - - 2014
Cluster-extent based thresholding is currently the most popular method for multiple comparisons correction of statistical maps in neuroimaging studies, due to its high sensitivity to weak and diffuse signals. However, cluster-extent based thresholding provides low spatial specificity; researchers can only infer that there is signal somewhere within a significant cluster ...
Dotu Ivan I Biology Department, Boston College, Chestnut Hill, Massachusetts, United States of - - 2014
We describe the first algorithm and software, RNAenn, to compute the partition function and minimum free energy secondary structure for RNA with respect to an extended nearest neighbor energy model. Our next-nearest-neighbor triplet energy model appears to lead to somewhat more cooperative folding than does the nearest neighbor energy model, ...
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