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Haned Hinda H Department of Human Biological Traces, Netherlands Forensic Institute, P.O. Box 24044, 2490 AA The Hague, The Netherlands. Electronic address: - - 2014
The interpretation of mixed DNA profiles obtained from low template DNA samples has proven to be a particularly difficult task in forensic casework. Newly developed likelihood ratio (LR) models that account for PCR-related stochastic effects, such as allelic drop-out, drop-in and stutters, have enabled the analysis of complex cases that ...
Fuchs Weizman Noga N Division of Minimally Invasive Gynecologic Surgery, Brigham and Women's Hospital, Boston, - - 2014
The aim of this study was to design and validate a new assessment tool for laparoscopic vaginal cuff suturing in a box trainer. A primary grading tool was constructed including a novel checklist component and a previously validated global rating scale. A four-step validation process was then undertaken. Face validity ...
Rafferty Katherine A KA Department of Communication, University of Wisconsin-Milwaukee, Johnston Hall, Room 210, P.O. Box 413, Milwaukee, WI, 53201, USA, - - 2014
Currently, 10 % of Americans are living with a chronic illness. One coping mechanism for individuals living with chronic illness is religion and/or spiritual (R/S). To better explicate the relationship among R/S and psychological well-being, we conceptualize R/S as an interpersonal process involving conversations that may facilitate positive reappraisals. We use ...
Fagertun Jens - - 2014
Manual annotation of landmarks is a known source of variance, which exist in all fields of medical imaging, influencing the accuracy and interpretation of the results. However, the variability of human facial landmarks is only sparsely addressed in the current literature as opposed to e.g. the research fields of orthodontics ...
Nguyen-Hoang Phuong P School of Urban and Regional Planning and Public Policy Center, University of Iowa, 344 Jessup Hall, Iowa City, IA 52242, USA. Electronic address: - - 2014
Introduction: This study examines the effect of highway capital investments on highway fatalities. Methods: We used state-level data from the 48 contiguous states in the United States from 1968 through 2010 to estimate the effects on highway fatalities of capital expenditures and highway capital stock. We estimated these effects by ...
Villeneuve Laurence L Department of Psychology,Université du Québec à - - 2014
ABSTRACT The principal objective of this study, the first of its kind to use this population, is to describe the factor analysis and validity of the Dyadic Adjustment Scale (EAD) among 895 French Canadian seniors living as couples. A confirmatory factor analysis was carried out using structural equation modeling. Results ...
Wei Li - - 2014
In this paper we introduce a simple, efficient, yet practical phoneme-based approach to generate realistic speech animation in real-time based on live speech input. Specifically, we first decompose lower-face movements into low-dimensional principal component spaces. Then, in each of the retained principal component space, we select the AnimPho with the ...
Lahodny G E GE Jr a Veterinary Integrative Biosciences , Texas A&M University , College Station , TX , - - 2014
Indirect transmission through the environment, pathogen shedding by infectious hosts, replication of free-living pathogens within the environment, and environmental decontamination are suspected to play important roles in the spread and control of environmentally transmitted infectious diseases. To account for these factors, the classic Susceptible-Infectious-Recovered-Susceptible epidemic model is modified to include ...
Aguirre Marisol M Top Institute of Food & Nutrition (TIFN), PO Box 557, 6700 AA Wageningen, The Netherlands; Maastricht University, School of Nutrition Toxicology and Metabolism (NUTRIM), Faculty of Health, Medicine and Life Sciences, Department of Human Biology, PO Box 616, 6200 MD, Maastricht, The Netherlands; The Netherlands Organization for Applied Scientific research (TNO), PO Box 360, 3700 AJ Zeist, The Netherlands. Electronic address: - - 2014
This study investigated the stability as well as the activity of the microbiota from a single and a pool of donors in the TNO in vitro model of the colon (TIM-2 system). Our findings underscore the substantial functional overlap in the microbiota of individuals when compared to a pool prepared ...
Han Jun-Ping JP People's Public Security University of China, Beijing 100038, PR - - 2014
Mixed semen stains from multiple contributors are challenging samples in sexual assault casework, and it is crucial to obtain the DNA profiles of different donors to allow the evidence to play an important role in investigations and judicial proceedings. Current standard procedures, including preferential lysis, are incapable of separating single-source ...
Wang Yi Y Department of Neuroscience, University of Virginia, Charlottesville, VA, - - 2014
Trans-sodium crocetinate (TSC) is a novel carotenoid compound capable of enhancing the diffusion of small molecules in aqueous solutions. TSC improves the diffusion of oxygen and glucose, and increases oxygenation in ischemic brain tissue. TSC also dampens the intensity of an ischemic challenge during an ongoing ischemic event. The current ...
Morais Jorge E JE Department of Sport Sciences, Polytechnic Institute of Bragança, Bragança, - - 2014
(i) apply a new method to identify, classify and follow-up young swimmers, based on their performance and its determinant factors over a season and (ii) analyze the swimmers' stability over a competitive season with that method. Fifteen boys and eighteen girls (11.8±0.7-y) part of a national talent ID scheme were ...
Kaptein Ronald G - - 2014
Identifying features for gait classification is a formidable problem. The number of candidate measures is legion. This calls for proper, objective criteria when ranking their relevance. Following a shotgun approach we determined a plenitude of kinematic and physiological gait measures and ranked their relevance using conventional analysis of variance (ANOVA) ...
Azevedo Coste Christine - - 2014
Walking impairment after stroke can be addressed with the use of drop foot stimulators (DFS). Many studies have demonstrated that DFS improves walking speed, reduces spasticity and reduces the physiologic effort of walking. Current DFS, through activation of the common peroneal nerve, elicit ankle dorsiflexion during swing phase of gait. ...
Sarlah Andreja A Faculty of Mathematics and Physics, University of Ljubljana, Ljubljana, - - 2014
Cytoplasmic dynein moves processively along microtubules, but the mechanism of how its heads use the energy from ATP hydrolysis, coupled to a linker swing, to achieve directed motion, is still unclear. In this article, we present a theoretical model based on the winch mechanism in which the principal direction of ...
Park Eun-Young - - 2014
Although activity and participation are the target domains in stroke rehabilitation interventions, there is insufficient evidence available regarding the validity of participation measurement. The purpose of this study was to investigate the psychometric properties of the London Handicap Scale in community-dwelling stroke patients, using Rasch analysis. Participants were 170 community-dwelling ...
Morgenstern Lewis B LB From the Stroke Program (L.B.M., D.L.B., M.A.S., D.B.Z., N.G., K.A.K., L.E.S., W.J.M., J.F.B., E.E.A., L.D.L.), Emergency Medicine (L.B.M., W.J.M.), Epidemiology (L.B.M., L.D.L.), and Biostatistics (B.N.S., J.B.), University of Michigan, Ann Arbor. - - 2014
Mexican Americans (MAs) were previously found to have lower mortality after ischemic stroke than non-Hispanic whites. We studied mortality trends in a population-based design. Active and passive surveillance were used to find all ischemic stroke cases from January 2000 to December 2011 in Nueces County, TX. Deaths were ascertained from ...
Wald Nicholas J NJ Wolfson Institute of Preventive Medicine, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK, - - 2014
Current methods of determining the proportion of people who benefit from a preventive intervention and the years of life gained can underestimate the former and overestimate the latter. We describe how to overcome these errors, using two examples relating to the prevention of myocardial infarction (MI) and stroke, one using ...
Zhang Jing - - 2014
We propose a novel method by using three new character features to detect text objects comprising two or more isolated characters in images and videos. A new text model is constructed to describe text objects. Each character is a part in the model and every two neighboring characters are connected ...
Montani Stefania S Dipartimento di Scienze e Innovazione Tecnologica, Computer Science Institute, Università del Piemonte Orientale, Viale Michel 11, I-15121 Alessandria, Italy. Electronic address: - - 2014
Process model comparison and similar process retrieval is a key issue to be addressed in many real-world situations, and a particularly relevant one in medical applications, where similarity quantification can be exploited to accomplish goals such as conformance checking, local process adaptation analysis, and hospital ranking. In this paper, we ...
Zuckerman S S Neurosurgery, Vanderbilt University Medical Center, Nashville, TN, - - 2014
Stroke is a major public health burden in the United States. In May 2012, the Vanderbilt Emergency Department (ED) Stroke Algorithm was implemented. The goal of our study was to: 1) describe the process of revising our stroke algorithm, and 2) compare pre- and post-algorithm implementation quality improvement (QI) data. ...
Kumamaru Hiraku H From the Department of Epidemiology, Harvard School of Public Health, Boston, MA (H.K.); Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (H.K., J.J.J.); Department of Biostatistics (S.E.J., J.D.R., G.H.) and Department of Epidemiology (J.R.C.), University of Alabama at Birmingham School of Public Health; Department of Medicine, University of Alabama at Birmingham School of Medicine (J.R.C., R.R., M.M.S.); Duke Clinical Research Institute, Department of Medicine, Duke University School of Medicine, Durham, NC (N.C.H., S.S.); Department of Neurology, University of Cincinnati, OH (B.M.K.); and Department of Neurology, Mayo Clinic, Jacksonville, FL - - 2014
The accuracy of stroke diagnosis in administrative claims for a contemporary population of Medicare enrollees has not been studied. We assessed the validity of diagnostic coding algorithms for identifying stroke in the Medicare population by linking data from the REasons for Geographic And Racial Differences in Stroke (REGARDS) Study to ...
Lich Kristen Hassmiller KH From the Department of Health Policy and Management, The University of North Carolina, Chapel Hill (K.H.L.); Program in Health Services and Systems Research, Duke-NUS Graduate Medical School, Singapore (Y.T., D.B.M.); Center for Health Services Research in Primary Care, Durham VAMC, NC (C.A.B., H.B.B.); VHA Health Services Research and Development Stroke Quality Enhancement Research Initiative, Indianapolis, IN (L.S.W., D.M.B.); VHA Health Services Research and Development Center of Excellence on Implementing Evidence-Based Practice, Richard L. Roudebush VHA Medical Center, Indianapolis, IN (L.S.W. D.M.B.); Regenstrief Institute, Indianapolis, IN (L.S.W., D.M.B.); Department of Veterans Affairs, Veterans Engineering Resource Center, VA-Center for Applied Systems Engineering, Indianapolis, IN (L.S.W.); Department of Internal Medicine, Indiana University School of Medicine, Indianapolis (D.M.B.); Department of Neurology, VA Greater Los Angeles Healthcare System, CA (E.M.C.); Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles (E.M.C.); Department of Medicine, Division of General Internal Medicine, Duke University, Durham, NC (H.B.B., D.B.M.); Homer Consulting, Voorhees, NJ (J.B.H.); and Duke Clinical Research Institute, Duke University, Durham, NC (D.B.M.). - - 2014
Reducing the burden of stroke is a priority for the Veterans Affairs Health System, reflected by the creation of the Veterans Affairs Stroke Quality Enhancement Research Initiative. To inform the initiative's strategic planning, we estimated the relative population-level impact and efficiency of distinct approaches to improving stroke care in the ...
Chang Chia-Hao CH a Department of Nursing , Chang Gung University Of Science and Technology, Chiayi Campus , Chiayi , Taiwan - - 2014
Threshold-dependent accuracy measures such as true classification rates in ordered multiple-class (k > 3) receiver operating characteristic (ROC) hyper-surfaces have recently been used to assist with medical decision making. However, based on low power performance in some circumstances, we construct a new method that relies on the kappa coefficient to ...
Tee Y K YK Institute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Oxford, UK; Centre for Doctoral Training in Healthcare Innovation, University of Oxford, Oxford, - - 2014
Amide proton transfer (APT) imaging is a pH mapping method based on the chemical exchange saturation transfer phenomenon that has potential for penumbra identification following stroke. The majority of the literature thus far has focused on generating pH-weighted contrast using magnetization transfer ratio asymmetry analysis instead of quantitative pH mapping. ...
Wikström Jakob J The Gait and Movement laboratory at Southern Älvsborg Hospital, Gång och Rörelselaboratoriet, Södra Älvsborgs Sjukhus, 501 82 Borås, - - 2014
Instrumented gait analysis (GA) may be used to analyze the causes of gait deviation in stroke patients but generates a large amount of complex data. The task of transforming this data into a comprehensible report is cumbersome. Intelligent data analysis (IDA) refers to the use of computational methods in order ...
Varewyck Machteld M Department of Applied Mathematics, Computer Science and Statistics, Ghent University, 9000 Ghent, - - 2014
We consider statistical methods for benchmarking clinical centers based on a dichotomous outcome indicator. Borrowing ideas from the causal inference literature, we aim to reveal how the entire study population would have fared under the current care level of each center. To this end, we evaluate direct standardization based on ...
Grech Reuben R Department of Neuroradiology, Beaumont Hospital, Dublin, Ireland - - - 2014
Functional outcome following emergent intra-arterial thrombectomy is variable and likely reflects the heterogeneous characteristics of acute stroke patients. The aims of our study were (1) to study which pre-treatment variables correlate with functional outcome and (2) to devise a tool which would reliably predict outcome. Prospective data of patients treated ...
Patel Rikesh R Sandwell and West Birmingham Hospitals NHS Trust, City Hospital, Cardiology Department , Birmingham , - - 2014
Introduction: Desmoteplase is an investigational plasminogen activator found in the saliva of the vampire bat, Desmodus rotundus. It has been of scientific interest for over 25 years as it exhibits pharmacological properties that have led to the hypothesis that desmoteplase may be safer and more effective than recombinant tissue plasminogen ...
Wang Guoli - - 2014
This paper presents a new approach to identify the stroke parameters in handwriting movement data understanding. A two-step analysis by synthesis paradigm is employed to facilitate the coarse-to-fine parameter identification for all strokes. One is the stroke data extraction, the other is the coarse-to-fine stroke parameter identification. The new consideration ...
Di Lascio Nicole N Institute of Clinical Physiology, National Research Council, Via G. Moruzzi 1, 56124, Pisa, Italy, - - 2014
Carotid pulse wave velocity (PWV) is considered as a surrogate marker for carotid stiffness and its assessment is increasingly being used in clinical practice. However, at the moment, its estimation needs specific equipment and a moderate level of technical expertise; moreover, it is based on a mathematical model. The aim ...
Thompson Douglas D - - 2014
The objective of this study was to: (1) systematically review the reporting and methods used in the development of clinical prediction models for recurrent stroke or myocardial infarction (MI) after ischemic stroke; (2) to meta-analyze their external performance; and (3) to compare clinical prediction models to informal clinicians' prediction in ...
Celik Güner G Department of Neurology, Faculty of Medicine, Baskent University, Konya, Turkey. Electronic address: - - 2014
The aim of the present study was to evaluate the performance of 2 different multivariate statistical methods and artificial neural networks (ANNs) in predicting the mortality of hemorrhagic and ischemic patients within the first 10 days after stroke. The multilayer perceptron (MLP) ANN model and multivariate statistical methods (multivariate discriminant analysis [MDA] ...
Kwiecien Timothy D - - 2014
Rodent models of ischemic stroke are associated with many issues and limitations, which greatly diminish the translational potential of these studies. Recent studies demonstrate that significant differences exist between rodent and human ischemic stroke. These differences include the physical characteristics of the stroke, as well as changes in the subsequent ...
Liebeskind David S - - 2014
Data drive the analyses of any ischemic stroke trial, culminating in the main results and potential next steps. The distinct purpose of a given trial, advancing a novel treatment or examining routine clinical practice, determines the nature of essential data elements. Information gathering for an effective trial depends on ample ...
Timsit S S Service de Neurologie et Unité Neuro-Vasculaire, CHRU Brest, Brest, - - 2014
Background: Population-based stroke registries are necessary to evaluate the precise burden of stroke. The methodology used in the Brest Stroke Registry and an estimation of its completeness are described. Methods: 'Hot pursuit' as well as 'cold pursuit' were used, and five sources of identification were included: emergency wards, brain imaging, ...
Whiteley William N WN From the Divisions of Clinical Neurosciences (W.N.W., G.C., P.S.) and Neuroimaging Sciences (J.W.), University of Edinburgh, Western General Hospital, Edinburgh, United Kingdom; Edinburgh MRC Hub for Trials Methodology Research, Centre for Population Health Sciences, University of Edinburgh, Edinburgh, United Kingdom (D.T., G.M.); and Neurological and Mental Health Division, The George Institute for Global Health, University of Sydney, Sydney, Australia - - 2014
Intravenous recombinant tissue-type plasminogen activator (r-tPA), despite a risk of early symptomatic intracranial hemorrhage (sICH), is of net clinical benefit to acute stroke patients. We tested if predictive models could identify patients least likely to be harmed by sICH or those who gained no net benefit. We used the Third ...
Holmes Michael M School of Health and Related Research (ScHARR), University of Sheffield, Sheffield, - - 2014
Identification of the underlying cause of stroke and transient ischaemic attack (TIA) is important so that preventative therapy can be used to reduce the risk of recurrence. Transthoracic echocardiography (TTE) and transoesophageal echocardiography (TOE) are diagnostic tools used to identify those cardiac sources of stroke that may respond to treatment. ...
Wong Jennifer S JS University of Toronto, Toronto, ON, Canada; Toronto Rehabilitation Institute - UHN, Toronto, ON, - - 2014
Technology-based assessment tools with semi-automated processing, such as pressure-sensitive mats used for gait assessment, may be considered to be objective; therefore it may be assumed that rater reliability is not a concern. However, user input is often required and rater reliability must be determined. The purpose of this study was ...
Jickling Glen C GC Department of Neurology, MIND Institute Wet Labs Room 2415, University of California at Davis Medical Center, 2805 50th Street, Sacramento, CA, 95817, USA, - - 2014
Despite testing more than 1,026 therapeutic strategies in models of ischemic stroke and 114 therapies in human ischemic stroke, only one agent tissue plasminogen activator has successfully been translated to clinical practice as a treatment for acute stroke. Though disappointing, this immense body of work has led to a rethinking ...
Xu Qingsong Q Department of Electromechanical Engineering, Faculty of Science and Technology, University of Macau, Av. Padre Tomás Pereira, Taipa, Macao SAR, - - 2014
Multi-stroke stages are demanded in micro-/nanopositioning applications which require smaller and larger motion strokes with fine and coarse resolutions, respectively. This paper presents the conceptual design of a novel multi-stroke, multi-resolution micropositioning stage driven by a single actuator for each working axis. It eliminates the issue of the interference among ...
White H Steve HS Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, UT, USA, - - 2014
A major unmet medical need is the lack of treatments to prevent (or modify) epilepsy in patients at risk, for example, after epileptogenic brain insults such as traumatic brain injury, stroke, or prolonged acute symptomatic seizures like complex febrile seizures or status epilepticus. Typically, following such brain insults there is ...
Heeg Bart M BM Pharmerit BV, Rotterdam, the Netherlands (BH, - - 2014
To increase power to detect a treatment effect, trials may combine multiple endpoints such as survival, myocardial infarctions, and strokes. When such trials are used to define the uncertainty associated with input parameters in an economic model, the output uncertainty will depend on the way in which the dependency between ...
Cadilhac Dominique A DA Stroke & Ageing Research Centre, Monash Medical Centre, Southern Clinical School, Monash University, Clayton, Victoria, Australia; Florey Institute of Neuroscience and Mental Health, Melbourne, Victoria, Australia; University of Melbourne, Melbourne, Victoria, - - 2014
Estimates of strokes in Australia are typically obtained using 1996-1997 age-specific attack rates from the pilot North East Melbourne Stroke Incidence (NEMESIS) Study (eight postcode regions). Declining hospitalizations for stroke indicate the potential to overestimate cases. To illustrate how current methods may potentially overestimate the number of strokes in Australia. ...
Asadi Hamed H Melbourne Brain Centre, Department of Medicine, Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, - - 2014
Stroke is a major cause of death and disability. Accurately predicting stroke outcome from a set of predictive variables may identify high-risk patients and guide treatment approaches, leading to decreased morbidity. Logistic regression models allow for the identification and validation of predictive variables. However, advanced machine learning algorithms offer an ...
Desland Fiona A FA Department of Neurological Surgery, Vanderbilt University, Nashville, TN, - - 2014
Animal models of stroke have been crucial in advancing our understanding of the pathophysiology of cerebral ischemia. Currently, the standards for determining neurological deficit in rodents are the Bederson and Garcia scales, manual assessments scoring animals based on parameters ranked on a narrow scale of severity. Automated open field analysis ...
Sheshka R R LMS, CNRS-UMR 7649, École Polytechnique, Route de Saclay, 91128 Palaiseau, France and LITEN, CEA-Grenoble, 17 rue des Martyrs, 38054 Grenoble Cedex 9, - - 2014
In ratchet-based models describing actomyosin contraction the activity is usually associated with actin binding potential while the power-stroke mechanism, residing inside myosin heads, is viewed as passive. To show that contraction can be propelled directly through a conformational change, we propose an alternative model where the power stroke is the ...
Grinberg Farida F Institute of Neuroscience and Medicine - 4, Forschungszentrum Juelich GmbH, Juelich, Germany ; Department of Neurology, Faculty of Medicine, JARA, RWTH Aachen University, Aachen, - - 2014
Recent diffusion MRI studies of stroke in humans and animals have shown that the quantitative parameters characterising the degree of non-Gaussianity of the diffusion process are much more sensitive to ischemic changes than the apparent diffusion coefficient (ADC) considered so far as the "gold standard". The observed changes exceeded that ...
Hill Jeff W JW University of New Mexico Health Sciences Center, Department of Neurology, Albuquerque, New Mexico, United States of - - 2014
Stroke is a leading cause of death and disability and treatment options are limited. A promising approach to accelerate the development of new therapeutics is the use of high-throughput screening of chemical libraries. Using a cell-based high-throughput oxygen-glucose deprivation (OGD) model, we evaluated 1,200 small molecules for repurposed application in ...
Ali Syed F SF Massachusetts General Hospital/Harvard Medical School, Boston, MA (S.F.A., A.V., A.B.S., N.S.R., - - 2014
Up to 30% of acute stroke evaluations are deemed stroke mimics (SM). As telestroke consultation expands across the world, increasing numbers of SM patients are likely being evaluated via Telestroke. We developed a model to prospectively identify ischemic SMs during Telestroke evaluation. We analyzed 829 consecutive patients from January 2004 ...
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