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Di Lascio Nicole N Institute of Clinical Physiology, National Research Council, Via G. Moruzzi 1, 56124, Pisa, Italy, - - 2014
Carotid pulse wave velocity (PWV) is considered as a surrogate marker for carotid stiffness and its assessment is increasingly being used in clinical practice. However, at the moment, its estimation needs specific equipment and a moderate level of technical expertise; moreover, it is based on a mathematical model. The aim ...
Thompson Douglas D - - 2014
The objective of this study was to: (1) systematically review the reporting and methods used in the development of clinical prediction models for recurrent stroke or myocardial infarction (MI) after ischemic stroke; (2) to meta-analyze their external performance; and (3) to compare clinical prediction models to informal clinicians' prediction in ...
Celik Güner G Department of Neurology, Faculty of Medicine, Baskent University, Konya, Turkey. Electronic address: - - 2014
The aim of the present study was to evaluate the performance of 2 different multivariate statistical methods and artificial neural networks (ANNs) in predicting the mortality of hemorrhagic and ischemic patients within the first 10 days after stroke. The multilayer perceptron (MLP) ANN model and multivariate statistical methods (multivariate discriminant analysis [MDA] ...
Kwiecien Timothy D - - 2014
Rodent models of ischemic stroke are associated with many issues and limitations, which greatly diminish the translational potential of these studies. Recent studies demonstrate that significant differences exist between rodent and human ischemic stroke. These differences include the physical characteristics of the stroke, as well as changes in the subsequent ...
Liebeskind David S - - 2014
Data drive the analyses of any ischemic stroke trial, culminating in the main results and potential next steps. The distinct purpose of a given trial, advancing a novel treatment or examining routine clinical practice, determines the nature of essential data elements. Information gathering for an effective trial depends on ample ...
Timsit S S Service de Neurologie et Unité Neuro-Vasculaire, CHRU Brest, Brest, - - 2014
Background: Population-based stroke registries are necessary to evaluate the precise burden of stroke. The methodology used in the Brest Stroke Registry and an estimation of its completeness are described. Methods: 'Hot pursuit' as well as 'cold pursuit' were used, and five sources of identification were included: emergency wards, brain imaging, ...
Whiteley William N WN From the Divisions of Clinical Neurosciences (W.N.W., G.C., P.S.) and Neuroimaging Sciences (J.W.), University of Edinburgh, Western General Hospital, Edinburgh, United Kingdom; Edinburgh MRC Hub for Trials Methodology Research, Centre for Population Health Sciences, University of Edinburgh, Edinburgh, United Kingdom (D.T., G.M.); and Neurological and Mental Health Division, The George Institute for Global Health, University of Sydney, Sydney, Australia - - 2014
Intravenous recombinant tissue-type plasminogen activator (rtPA), despite a risk of early symptomatic intracranial hemorrhage (sICH), is of net clinical benefit to acute stroke patients. We tested if predictive models could identify patients least likely to be harmed by sICH or those who gained no net benefit. We used the Third ...
Holmes Michael M School of Health and Related Research (ScHARR), University of Sheffield, Sheffield, - - 2014
Identification of the underlying cause of stroke and transient ischaemic attack (TIA) is important so that preventative therapy can be used to reduce the risk of recurrence. Transthoracic echocardiography (TTE) and transoesophageal echocardiography (TOE) are diagnostic tools used to identify those cardiac sources of stroke that may respond to treatment. ...
Wong Jennifer S JS University of Toronto, Toronto, ON, Canada; Toronto Rehabilitation Institute - UHN, Toronto, ON, - - 2014
Technology-based assessment tools with semi-automated processing, such as pressure-sensitive mats used for gait assessment, may be considered to be objective; therefore it may be assumed that rater reliability is not a concern. However, user input is often required and rater reliability must be determined. The purpose of this study was ...
Jickling Glen C GC Department of Neurology, MIND Institute Wet Labs Room 2415, University of California at Davis Medical Center, 2805 50th Street, Sacramento, CA, 95817, USA, - - 2014
Despite testing more than 1,026 therapeutic strategies in models of ischemic stroke and 114 therapies in human ischemic stroke, only one agent tissue plasminogen activator has successfully been translated to clinical practice as a treatment for acute stroke. Though disappointing, this immense body of work has led to a rethinking ...
Xu Qingsong Q Department of Electromechanical Engineering, Faculty of Science and Technology, University of Macau, Av. Padre Tomás Pereira, Taipa, Macao SAR, - - 2014
Multi-stroke stages are demanded in micro-/nanopositioning applications which require smaller and larger motion strokes with fine and coarse resolutions, respectively. This paper presents the conceptual design of a novel multi-stroke, multi-resolution micropositioning stage driven by a single actuator for each working axis. It eliminates the issue of the interference among ...
White H Steve HS Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, UT, USA, - - 2014
A major unmet medical need is the lack of treatments to prevent (or modify) epilepsy in patients at risk, for example, after epileptogenic brain insults such as traumatic brain injury, stroke, or prolonged acute symptomatic seizures like complex febrile seizures or status epilepticus. Typically, following such brain insults there is ...
Heeg Bart M BM Pharmerit BV, Rotterdam, the Netherlands (BH, - - 2014
To increase power to detect a treatment effect, trials may combine multiple endpoints such as survival, myocardial infarctions, and strokes. When such trials are used to define the uncertainty associated with input parameters in an economic model, the output uncertainty will depend on the way in which the dependency between ...
Cadilhac Dominique A DA Stroke & Ageing Research Centre, Monash Medical Centre, Southern Clinical School, Monash University, Clayton, Victoria, Australia; Florey Institute of Neuroscience and Mental Health, Melbourne, Victoria, Australia; University of Melbourne, Melbourne, Victoria, - - 2014
Estimates of strokes in Australia are typically obtained using 1996-1997 age-specific attack rates from the pilot North East Melbourne Stroke Incidence (NEMESIS) Study (eight postcode regions). Declining hospitalizations for stroke indicate the potential to overestimate cases. To illustrate how current methods may potentially overestimate the number of strokes in Australia. ...
Asadi Hamed H Melbourne Brain Centre, Department of Medicine, Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, - - 2014
Stroke is a major cause of death and disability. Accurately predicting stroke outcome from a set of predictive variables may identify high-risk patients and guide treatment approaches, leading to decreased morbidity. Logistic regression models allow for the identification and validation of predictive variables. However, advanced machine learning algorithms offer an ...
Desland Fiona A FA Department of Neurological Surgery, Vanderbilt University, Nashville, TN, - - 2014
Animal models of stroke have been crucial in advancing our understanding of the pathophysiology of cerebral ischemia. Currently, the standards for determining neurological deficit in rodents are the Bederson and Garcia scales, manual assessments scoring animals based on parameters ranked on a narrow scale of severity. Automated open field analysis ...
Sheshka R R LMS, CNRS-UMR 7649, École Polytechnique, Route de Saclay, 91128 Palaiseau, France and LITEN, CEA-Grenoble, 17 rue des Martyrs, 38054 Grenoble Cedex 9, - - 2014
In ratchet-based models describing actomyosin contraction the activity is usually associated with actin binding potential while the power-stroke mechanism, residing inside myosin heads, is viewed as passive. To show that contraction can be propelled directly through a conformational change, we propose an alternative model where the power stroke is the ...
Grinberg Farida F Institute of Neuroscience and Medicine - 4, Forschungszentrum Juelich GmbH, Juelich, Germany ; Department of Neurology, Faculty of Medicine, JARA, RWTH Aachen University, Aachen, - - 2014
Recent diffusion MRI studies of stroke in humans and animals have shown that the quantitative parameters characterising the degree of non-Gaussianity of the diffusion process are much more sensitive to ischemic changes than the apparent diffusion coefficient (ADC) considered so far as the "gold standard". The observed changes exceeded that ...
Aaronson Justine A JA Heliomare Research & Development, Wijk aan Zee, the Netherlands; University of Amsterdam, Department of Psychology, Amsterdam, the Netherlands. Electronic address: - - 2013
To determine whether a prediction model combining self-reported symptoms, socio-demographic and clinical parameters could serve as a reliable first screening method in a step-by-step diagnostic approach to sleep apnea syndrome (SAS) in stroke rehabilitation. Retrospective study. Rehabilitation center. A consecutive sample of 620 stroke patients admitted between May 2007 and ...
Romero Gregorio G CITEF, Universidad Politecnica de Madrid, C. Jose Gutierrez Abascal 2, 28006 Madrid, - - 2013
The World Health Organization estimates that 17 million people die of cardiovascular disease, particularly heart attacks and strokes, every year. Most strokes are caused by a blood clot that occludes an artery in the cerebral circulation and the process concerning the removal of this obstruction involves catheterisation. The fundamental object ...
Mayo Nancy E NE Division of Clinical Epidemiology, Royal Victoria Hospital Site, McGill University Health Center, Ross Pavilion R4.29, Montreal, QC, Canada, - - 2013
The Wilson-Cleary (W-C) model of health-related quality of life (HRQL) has not been tested in stroke, and a better understanding of the components of HRQL during recovery would lead to a more integrated and person-centered approach to health management and outcome optimization for this vulnerable population. To enhance our understanding ...
Walker Frederick R - - 2013
Over the last decade there has been a considerable effort directed toward reformulating the standard approach taken to preclinically model stroke and stroke recovery. The principal objective of this undertaking has been to improve the success with which preclinical findings can be translated. Although several advancements have already been introduced, ...
Crowther Michael J - - 2013
Methodological development of joint models of longitudinal and survival data has been rapid in recent years; however, their full potential in applied settings are yet to be fully explored. We describe a novel use of a specific association structure, linking the two component models through the subject specific intercept, and ...
Yoo Doo Han DH Department of Occupational Therapy, Chonbuk National University Hospital, Republic of - - 2013
[Purpose] The aim of this study was to standardize the clock drawing test (CDT) for people with stroke using Rasch analysis. [Subjects and Methods] Seventeen items of the CDT identified through a literature review were performed by 159 stroke patients. The data was analyzed with Winstep version 3.57 using the ...
Demaerschalk Bart M BM Divisions of Vascular, Hospital, and Critical Care Neurology, Department of Neurology, Mayo Clinic, 5777 E Mayo Blvd, Phoenix, AZ 85054. E-mail: - - 2013
Background: A hub-and-spoke telestroke network is an effective way to extend quality emergency stroke care to remote hospitals and improve patient outcomes. Objectives: To evaluate the cost utility of a telestroke network in the management of acute ischemic stroke from the societal perspective. Study Design and Methods: A lifetime Markov ...
Vanroy Christel - - 2013
Abstract Purpose: Determine validity and reliability of SenseWear Pro2 Armband (SWP2A) and Yamax Digi-Walker SW-200 Pedometer (YDWP) in stroke and healthy adults. Methods: Fifteen stroke patients and 15 healthy participants wore SWP2A on upper arm and YDWP at hip/knee. Different activities were performed: treadmill walking, walking up/down a step, cycling ...
Ademi Zanfina - - 2013
To determine the cost-effectiveness of apixaban versus warfarin in patients with atrial fibrillation (AF) with a moderate to severe risk of stroke, from an Australian government-perspective. A decision-analytic Markov model was constructed to assess the cost-effectiveness of apixaban versus warfarin, based on data from the Apixaban for Reduction in Stroke ...
Duberstein Kylee Jo - - 2013
Severity of neural injury including stroke in human patients, as well as recovery from injury, can be assessed through changes in gait patterns of affected individuals. Similar quantification of motor function deficits have been measured in rodent animal models of such injuries. However, due to differences in fundamental structure of ...
Liu Ye - - 2013
Stroke is one of the most common disorders among the elderly. A practical problem in stroke rehabilitation systems is that how to separate motor imagery patterns from electroencephalographic (EEG) recordings. There is a sharp decline in performance of these systems when classical algorithms, such as Common Spatial Pattern (CSP), are ...
Murphy Alistair P - - 2013
To investigate the discrepancy between coach and athlete perceptions of internal load and notational analysis of external load in elite junior tennis. Fourteen elite junior tennis players and 6 international coaches were recruited. Ratings of perceived exertion (RPE) were recorded for individual drills and whole sessions, along with a rating ...
Phillips L Alison - - 2013
Perceptions that stress causes and stress-reduction controls hypertension have been associated with poorer blood pressure (BP) control in hypertension populations. The current study investigated these "stress-model perceptions" in stroke survivors regarding prevention of recurrent stroke and the influence of these perceptions on patients' stroke risk factor control. Stroke and transient ...
Small Steven L - - 2013
Following stroke, patients are commonly left with debilitating motor and speech impairments. This article reviews the state of the art in neurological repair for stroke and proposes a new model for the future. We suggest that stroke treatment-from the time of the ictus itself to living with the consequences-must be ...
Zhao Yong-Qi - - 2013
Because of the aggressive threaten of heat stroke and a lack of understanding of the mechanism of action, mammal animal models for experimental heat stroke were well developed. During the past 5 decades, anesthetized mouse, rat, rabbit, dog, baboon and monkey were used as animal model for experimental heat stroke. ...
Hotter Benjamin - - 2013
Background: Randomized controlled clinical trials are the gold standard for scientific evaluation of clinical diagnostic and treatment concepts. Frequently, recruitment of participants is slower than expected, especially in acute conditions with a short time frame for inclusion. Simple prediction models have been proposed to extrapolate recruitment rates. We hypothesized a ...
Simard J Marc - - 2013
The sulfonylurea receptor 1 (Sur1)-transient receptor potential 4 (Trpm4) channel is an important molecular element in focal cerebral ischemia. The channel is upregulated in all cells of the neurovascular unit following ischemia, and is linked to microvascular dysfunction that manifests as edema formation and secondary hemorrhage, which cause brain swelling. ...
Barth Albert M I - - 2013
Just like human neurological disorders, corresponding mouse models present multiple deficiencies. Estimating disease progression or potential treatment effectiveness in such models necessitates the use of time consuming and multiple tests usually requiring a large number of scarcely available genetically modified animals. New method Here we present a novel and simple ...
Andrade A G P - - 2013
Lower extremity kinetic data during walking of 12 people with chronic post-stroke were re-analyzed, using functional analysis of variance (FANOVA). To perform the FANOVA, the whole curve is represented by a mathematical function, which spans the whole gait cycle and avoids the need to identify isolated points, as required for ...
Liu Yao - - 2013
Gait analysis is a systematic collection of quantitative information on bodily movements during locomotion. Gait analysis has been employed clinically in stroke patients for their rehabilitation planning. In animal studies, gait analysis has been employed for the assessment their locomotive disturbances in ischemic stroke, spinal cord injury and Parkinson's disease. ...
Yessis Jennifer - - 2013
The Heart and Stroke Foundation's Spark Together for Healthy Kids™ (Spark) is a multiyear initiative in Ontario, Canada, that takes a population approach to obesity prevention. It focuses on creating healthy environments by improving access to healthy foods and physical activity, with an emphasis on strengthening the advocacy capacity of ...
Sokal Brad - - 2013
To test the convergent validity of an objective method, Sensor-Enabled Radio-frequency Identification System for Monitoring Arm Activity (SERSMAA), that distinguishes between functional and nonfunctional activity. After stroke, laboratory tests of the motor capacity of the more-affected arm poorly predict spontaneous use of that arm in daily life. However, available subjective ...
Fulk George D - - 2013
Advances in sensor technologies and signal processing techniques provide a method to accurately measure walking activity in the home and community. Activity monitors geared towards consumer/patient use may be an alternative to more expensive monitors designed for research to measure stepping activity. The objective of this study was to examine ...
Ramalle-Gomara Enrique - - 2013
Background: Hospital administrative data have been suggested as a valuable cost-effective tool for providing information about the stroke burden. Nevertheless, the choice of the diagnosis codes has been a critical issue in the development of case ascertainment algorithms. Methods: In this study, the Minimum Basic Data Set administrative database was ...
Dhand Amar - - 2013
Study of diagnostic practice is necessary to optimize neurologists' clinical performance and ensure patient safety. To our knowledge, this report is the first set of systematic observations of diagnostic practices of community neurologists in their clinics. The study consisted of six 2-week periods of in situ observations and interviews of ...
Béjot Yannick - - 2013
Background: We aimed to determine the accuracy of the iScore for predicting mortality and early disability following ischemic stroke in a French population-based study. Methods: All patients with acute ischemic stroke were identified among residents of the city of Dijon, France, between 2006 and 2011, using a population-based stroke registry. ...
Sekine Kazuki - - 2013
For many individuals with aphasia, gestures form a vital component of message transfer and are the target of speech-language pathology intervention. What remains unclear is the participant variables that predict successful outcomes from gesture treatments. We examined the gesture production of a large number of individuals with aphasia, in a ...
Kastorini Christina-Maria - - 2013
To compare the accuracy of a-priori and a-posteriori dietary patterns in the prediction of acute coronary syndrome (ACS) and ischemic stroke. This is actually the first study to employ state-of-the-art classification methods for this purpose. During 2009-2010, 1000 participants were enrolled; 250 consecutive patients with a first ACS and 250 ...
Frank Benedikt - - 2013
Reliable estimates of intracluster correlation coefficients (ICCs) for specific outcome measures are crucial for sample size calculations of future cluster randomized trials. ICCs indicate the proportion of data variability that is explained by defined levels of clustering. In this manuscript, we present potentially valuable and reliable estimates of ICCs for ...
McDonnell Lisa K - - 2013
The aim of this narrative review was to propose a deterministic model based on a review of previous research documenting the evidence for the associations between average kayak velocity and kinematic variables in sprint kayaking. Literature was reviewed after searching electronic databases using key words 'kayak,' 'biomechanics,' 'velocity,' 'kinematics,' and ...
Kwah Li Khim LK School of Physiotherapy, Australian Catholic University, - - 2013
What is the incidence of recovery of ambulation and upper limb function six months after stroke? Can measures such as age and the National Institutes of Health Stroke Scale (NIHSS) be used to develop models to predict the recovery of ambulation and upper limb function? Prospective cohort study. Consecutive sample ...
McMeekin Peter - - 2013
Prehospital redirection of stroke patients to a regional center is used as a strategy to maximize the provision of intravenous thrombolysis. We developed a model to quantify the benefit of redirection away from local services that were already providing thrombolysis. A microsimulation using hospital and ambulance data from consecutive emergency ...
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