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Read Gemma J M GJ a Human Factors Group, Monash Injury Research Institute, Accident Research Centre, Monash University , Clayton Victoria - - 2014
Cognitive work analysis (CWA) is a framework of methods for analysing complex sociotechnical systems. However, the translation from the outputs of CWA to design is not straightforward. Sociotechnical systems theory provides values and principles for the design of sociotechnical systems which may offer a theoretically consistent basis for a design ...
Olsen Inge Christoffer IC Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway. - - 2014
The use of electronic health records (EHR) is an essential part of modern health care, and electronic data capture (EDC) has become essential for managing clinical trials. Usually, these two entities are independent of each other, and transfer from one system to another is done manually. Our aim was to ...
Hsueh Yao-Chu - - 2014
In this paper, a novel fuzzy structure termed as the decomposed fuzzy system (DFS) is proposed to act as the fuzzy approximator for adaptive fuzzy control systems. The proposed structure is to decompose each fuzzy variable into layers of fuzzy systems, and each layer is to characterize one traditional fuzzy ...
Yang Junggi J Department of IT Convergence Engineering, Gachon University, Seongnam, - - 2014
Anaphora recognition is a process to identify exactly which noun has been used previously and relates to a pronoun that is included in a specific sentence later. Therefore, anaphora recognition is an essential element of a dialogue agent system. In the current study, all the merits of rule-based, machine learning-based, ...
Yang Yimin - - 2014
As the most important property of neural networks (NNs), the universal approximation capability of NNs is widely used in many applications. However, this property is generally proven for continuous systems. Most industrial systems are hybrid systems (e.g., piecewise continuous), which is a significant limitation for real applications. Recently, many identification ...
Watson Penny P School of Health and Related Research, University of Sheffield, Sheffield, UK, Global Health Outcomes, GlaxoSmithKline, Uxbridge, UK and Department of Medicine-Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. - - 2014
The aim of this study was to develop an SLE disease model that simulates long-term outcomes of SLE to estimate the long-term effectiveness and cost-effectiveness of SLE treatments. Longitudinal data from 1354 patients from the Hopkins Lupus Cohort were included in the analysis. Statistical models were created to estimate disease ...
Chen Ping P Pharmacokinetics and Drug Metabolism, Thousand Oaks, California, USA, - - 2014
To investigate the relationships between AMG 811 exposure, concentration changes in serum IFN-γ, and IFN-γ-induced protein 10 (CXCL10), and to identify important contributions of baseline covariates to these relationships. A mechanism based pharmacokinetic (PK)-pharmacodynamic (PD) model was developed. A target mediated disposition model was used to describe AMG 811 and ...
Kwong Raymond H - - 2014
Most model-based approaches to fault diagnosis of discrete-event systems require a complete and accurate model of the system to be diagnosed. However, the discrete-event model may have arisen from abstraction and simplification of a continuous time system, or through model building from input-output data. As such, it may not capture ...
Li Yuhui Y Department of Rheumatology and Immunology, Clinical Immunology Center, Peking University People's Hospital, 11 Xizhimen South Street, 100044, Beijing, - - 2014
Primary Sjögren's syndrome (pSS) is a systemic autoimmune disease that lacks sensitive and specific diagnostic methods. The aim of this study was to identify potential biomarkers specific for pSS and to establish a diagnostic model. Serum samples from patients with pSS, disease controls (DC, patients with systemic lupus erythematosus (SLE), ...
Yasunaga Hideo H Department of Clinical Epidemiology and Health Economics, School of Public Health, The University of Tokyo, - - 2014
The Diagnosis Procedure Combination (DPC) is a case-mix classification system that is linked with a lump-sum payment system for inpatient care reimbursement. The key objectives of introducing the DPC system are to implement an electronic claim system and to provide transparency of hospital performance. The DPC data include discharge abstract ...
Donaghy Josephine J Department of Sociology, Philosophy and Anthropology & Egenis, University of Exeter, Byrne House, St Germans Road, Exeter EX4 4PJ, UK. Electronic address: - - 2014
In 'Discovering complexity' Bechtel and Richardson (1993) highlighted the connection between how biologists investigate the world and the type of explanations they give. This paper extends their account of how we investigate the world by examining the strategies used by researchers to build mathematical models of complex metabolic systems between ...
Jeltsch-David Hélène H CNRS, Immunopathologie et chimie thérapeutique/Laboratory of excellence Medalis, Institut de Biologie Moléculaire et Cellulaire, 67000 Strasbourg, France. Electronic address: - - 2014
Mouse models of autoimmunity, such as (NZB×NZW)F1, MRL/MpJ-Fas(lpr) (MRL-lpr) and BXSB mice, spontaneously develop systemic lupus erythematosus (SLE)-like syndromes with heterogeneity and complexity that characterize human SLE. Despite their inherent limitations, such models have highly contributed to our current understanding of the pathogenesis of SLE as they provide powerful tools ...
Li Yun - - 2014
Two factors characterize a good feature selection algorithm: its accuracy and stability. This paper aims at introducing a new approach to stable feature selection algorithms. The innovation of this paper centers on a class of stable feature selection algorithms called feature weighting as regularized energy-based learning (FREL). Stability properties of ...
Liu Fei F Control and Simulation Center, Harbin Institute of Technology, Postbox 3006, 150080 Harbin, China. Electronic address: - - 2014
Reaction-diffusion systems often play an important role in systems biology when developmental processes are involved. Traditional methods of modelling and simulating such systems require substantial prior knowledge of mathematics and/or simulation algorithms. Such skills may impose a challenge for biologists, when they are not equally well-trained in mathematics and computer ...
Ruiz-Ares Gerardo G Department of Neurology, Stroke Center, La Paz University Hospital, IdiPAZ Health Research Institute, Universidad Autónoma de Madrid, Madrid, - - 2014
The aim of this prospective study was to analyze the utility of a gray-scale median (GSM) system for identifying unstable plaques and to design and validate a prediction model for unstable plaques in symptomatic atheromatous carotid arteries. Fifty-two patients with non-cardioembolic cerebral infarction were included in the study. The receiver ...
Joughin Ian I Polar Science Center, Applied Physics Lab, University of Washington, 1013 NE 40th Street, Seattle, WA - - 2014
Resting atop a deep marine basin, the West Antarctic Ice Sheet has long been considered prone to instability. Using a numerical model, we investigate the sensitivity of Thwaites Glacier to ocean melt and whether unstable retreat is already underway. Our model reproduces observed losses when forced with ocean melt comparable ...
Cantarel Brandi L - - 2014
Accurate genomic variant detection is an essential step in gleaning medically useful information from genome data. However, low concordance among variant-calling methods reduces confidence in the clinical validity of whole genome and exome sequence data, and confounds downstream analysis for applications in genome medicine. Here we describe BAYSIC (BAYeSian Integrated ...
Mance D D Stable Isotope Laboratory, School of Medicine, University of Rijeka, Croatia. Electronic address: - - 2014
Here we present the results of the first systematic analysis of the stable isotope composition of the karst hydrological systems in the Bay of Kvarner. Gaussian mixture modelling, time series analysis and autoregressive integrated moving average (ARIMA) modelling were applied using the stable isotope compositions of the karst groundwater. This ...
Radivojević Tijana T BCAM - Basque Center for Applied Mathematics, Bilbao, Basque Country, - - 2014
We study a phenomenological model for the continuous double auction, whose aggregate order process is equivalent to two independent [Formula: see text] queues. The continuous double auction defines a continuous-time random walk for trade prices. The conditions for ergodicity of the auction are derived and, as a consequence, three possible ...
Kashihara Shigeru S 0000-0001-9603-8297 Graduate School of Information Science, Nara Institute of Science and Technology, Takayama, Ikoma, Nara 8916-5, - - 2014
This paper proposes a data delivery method based on neighbor nodes' information to achieve reliable communication in a mobile ad hoc network (MANET). In a MANET, it is difficult to deliver data reliably due to instabilities in network topology and wireless network condition which result from node movement. To overcome ...
Barro Seydou Golo SG Aix-Marseille University, UMR912 SESSTIM Inserm, Marseille, - - 2014
: In Africa, mortality statistics are not reliable due to the low performance of the death registering systems. Our aim is to implement an efficient system. In this article we make a comparison between the existing system model and the new system that will be set up. UML has been ...
Rodrigues Jean-Marie JM INSERM U1142, LIMICS, Paris, - - 2014
The improvement of semantic interoperability between data in electronic health records and aggregated data for health statistics requires efforts to carefully align the two domain terminologies ICD and SNOMED CT. Both represent a new generation of ontology-based terminologies and classifications. The proposed alignment of these two systems and, in consequence, ...
He Dayi D School of Humanities & Economic Management, Lab of Resources & Environment Management, China University of Geosciences (Beijing), Beijing, P. R. - - 2014
In related research on queuing systems, in order to determine the system state, there is a widespread practice to assume that the system is stable and that distributions of the customer arrival ratio and service ratio are known information. In this study, the queuing system is looked at as a ...
Habib Ayman A Department of Geomatics Engineering, University of Calgary, 2500 University Drive NW, Calgary, AB, T2N 1N4, Canada. - - 2014
Consumer-grade digital cameras suffer from geometrical instability that may cause problems when used in photogrammetric applications. This paper provides a comprehensive review of this issue of interior orientation parameter variation over time, it explains the common ways used for coping with the issue, and describes the existing methods for performing ...
Fan Chen C College of Mechatronics and Automation, National University of Defense Technology, Changsha 410073, China. - - 2014
Gyroscopes based on micro-electromechanical system (MEMS) technology suffer in high-dynamic applications due to obvious g-sensitivity errors. These errors can induce large biases in the gyroscope, which can directly affect the accuracy of attitude estimation in the integration of the inertial navigation system (INS) and the Global Positioning System (GPS). The ...
Abby Sophie S SS Microbial Evolutionary Genomics, Institut Pasteur, Paris, France; UMR3525, CNRS, Paris, - - 2014
Biologists often wish to use their knowledge on a few experimental models of a given molecular system to identify homologs in genomic data. We developed a generic tool for this purpose. Macromolecular System Finder (MacSyFinder) provides a flexible framework to model the properties of molecular systems (cellular machinery or pathway) ...
Wilson Andrew D AD The Department of Mechanical Engineering, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208, - - 2014
This paper develops an optimization method to synthesize trajectories for use in the identification of system parameters. Using widely studied techniques to compute Fisher information based on observations of nonlinear dynamical systems, an infinite-dimensional, projection-based optimization algorithm is formulated to optimize the system trajectory using eigenvalues of the Fisher information ...
Cong Er-Ding - - 2013
In this manuscript, based on Smith predictor control scheme for unstable process in industry, an improved double loop control model is proposed for chemical unstable processes. Inner loop is to stabilize integrating the unstable process and transform the original process to first-order plus pure dead-time dynamic stable process. Outer loop ...
Sherratt Jonathan A - - 2013
Mathematical models have been highly successful at reproducing the complex spatiotemporal phenomena seen in many biological systems. However, the ability to numerically simulate such phenomena currently far outstrips detailed mathematical understanding. This paper reviews the theory of absolute and convective instability, which has the potential to redress this inbalance in ...
Li Shuo - - 2013
Quantitative analysis of Raman spectra using Surface Enhanced Raman scattering (SERS) nanoparticles has shown the potential and promising trend of development in invivo molecular imaging. Partial Least Square Regression (PLSR) methods have been reported as state-of-the-art methods. However, the approaches fully rely on the intensities of Raman spectra and can ...
Sudar Martina - - 2013
Two d-fructose-6-phosphate aldolase variants namely, single variant FSA A129S and double variant FSA A129S/A165G, were used as catalysts in the aldol addition of dihydroxyacetone (DHA) to N-Cbz-3-aminopropanal. Mathematical model for reaction catalyzed by both enzymes, consisting of kinetic and mass balance equations, was developed. Kinetic parameters were estimated from the ...
Moran James J - - 2013
We analyzed 21 neat acetone samples from 15 different suppliers to demonstrate the utility of a coupled stable isotope and trace contaminant strategy for distinguishing forensically-relevant samples. By combining these two pieces of orthogonal data we could discriminate all of the acetones that were produced by the 15 different suppliers. ...
Long Nanye - - 2013
Although many methods are available to test sequence variants for association with complex diseases and traits, methods that specifically seek to identify causal variants are less developed. Here we develop and evaluate a Bayesian hierarchical regression method that incorporates prior information on the likelihood of variant causality through weighting of ...
You Hongzhi - - 2013
Neuroscientists have carried out comprehensive experiments to reveal the neural mechanisms underlying the perceptual decision making that pervades daily life. These experiments have illuminated salient features of decision making, including probabilistic choice behavior, the ramping activity of decision-related neurons, and the dependence of decision time and accuracy on the difficulty ...
Lippert Christoph - - 2013
Applications of linear mixed models (LMMs) to problems in genomics include phenotype prediction, correction for confounding in genome-wide association studies, estimation of narrow sense heritability, and testing sets of variants (e.g., rare variants) for association. In each of these applications, the LMM uses a genetic similarity matrix, which encodes the ...
Lee W W Department of Obstetrics and Gynecology, Oakland University William Beaumont School of Medicine, Rochester, MI, USA. - - 2013
To prospectively validate the use of fractional limb volume measurements for estimated fetal weight (EFW) during the second and third trimesters of pregnancy and to summarize the medical literature regarding application of fractional limb volume for fetal weight estimation. One hundred and sixty-four women prospectively underwent three-dimensional ultrasonography within 4 days ...
Nov Yuval - - 2013
Saturation mutagenesis is a widely used directed evolution technique, in which a large number of protein variants, each having random amino acids in certain predetermined positions, are screened in order to discover high-fitness variants among them. Several metrics for determining the library size (the number of variants screened) have been ...
Alemu Kassahun - - 2013
Malaria elimination requires successful nationwide control efforts. Detecting the spatiotemporal distribution and mapping high-risk areas are useful to effectively target pockets of malaria endemic regions for interventions. The aim of the study was to identify patterns of malaria distribution by space and time in unstable malaria transmission areas in northwest ...
Forouzanfar Mohammad H - - 2012
Ischemic Heart Disease (IHD) is the leading cause of death worldwide. The Global Burden of Diseases, Injuries and Risk Factors (GBD) 2010 Study estimated IHD mortality and disability burden for 21 world regions for the years 1990 to 2010. Data sources for GBD IHD epidemiology estimates were mortality surveillance, verbal ...
Sandberg Paul A - - 2012
Stable isotope analysis has become an important tool in ecology over the last 25 years. A wealth of ecological information is stored in animal tissues in the relative abundances of the stable isotopes of several elements, particularly carbon and nitrogen, because these isotopes navigate through ecological processes in predictable ways. ...
Feng Zhujing - - 2012
Nitrate-nitrogen concentrations in rivers represent challenges for water supplies that use surface water sources. Nitrate concentrations are often modeled using time-series approaches, but previous efforts have typically relied on monthly time steps. In this study, we developed a dynamic regression model of daily nitrate concentrations in the Raccoon River, Iowa, ...
Wentink E C - - 2012
Gait initiation in transfemoral amputees (TFA) is different from non-amputees. This is mainly caused by the lack of stability and push-off from the prosthetic leg. Adding control and artificial push-off to the prosthesis may therefore be beneficial to TFA. In this study the feasibility of real-time intention detection of gait ...
Rudy Krista - - 2012
PURPOSE: This study sought to investigate the effect of palate morphology and anthropometric measures of the head on positional variability of the tongue during consonants. METHOD: An electromagnetic tracking system was used to record tongue movements of 21 adults. Each talker produced a series of symmetrical VCV syllables containing one ...
Westwick David T - - 2012
Estimates of joint or limb impedance are commonly used in the study of how the nervous system controls posture and movement, and how that control is altered by injury to the neural or musculoskeletal systems. Impedance characterizes the dynamic relationship between an imposed perturbation of joint position and the torques ...
Lin C - - 2012
This paper presents a wearable module and neural-network-based activity classification algorithm for energy expenditure estimation. The purpose of our design is first to categorize physical activities with similar intensity levels, and then to construct energy expenditure regression (EER) models using neural networks in order to optimize the estimation performance. The ...
Georgakarakos Efstratios - - 2012
Purpose: To evaluate the displacement forces acting on an aortic endograft when the iliac limbs are crossed ("ballerina" position). Methods: An endograft model was computationally reconstructed based on data from a patient whose infrarenal aortic aneurysm had an endovascular stent-graft implanted with the iliac limbs crossed. Computational fluid dynamics analysis ...
Li L - - 2012
The precise control of spiking in a population of neurons via applied electrical stimulation is a challenge due to the sparseness of spiking responses and neural system plasticity. We pose neural stimulation as a system control problem where the system input is a multidimensional time-varying signal representing the stimulation, and ...
Mootnick Alan R - - 2012
Although there have been few studies of self-scratching in primates, some have reported distinct differences in whether hands or feet are used, and these variations seem to reflect the evolutionary history of the Order. Monkeys and prosimians use both hands and feet to self-scratch while African great apes use hands ...
Tang Gang - - 2012
The kinematical parameters such as translational acceleration and angular acceleration in the upper limb of a weightlifter may change regularly during different phases of squat snatch. This study aims to make this question clear. At first, the joint coordinate system (JCS) of human upper limb based on the anatomical landmarks ...
Chiu Y C - - 2012
The objective of this research was to conduct a human factors engineering analysis of a grafting robot design using computer-aided 3D simulation technology. A prototype tubing-type grafting robot for fruits and vegetables was the subject of a series of case studies. To facilitate the incorporation of human models into the ...
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