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Gibbons Melissa M MM Department of Mechanical and Aerospace Engineering, UCLA, 420 Westwood Plaza, Los Angeles, CA, 90095, - - 2015
Viral capsids undergo significant mechanical deformations during their assembly, maturation, and infective life-span. In order to characterize the mechanics of viral capsids, their response to applied external forces is analyzed in several experimental studies using, for instance, Atomic Force Microscope (AFM) indentation experiments. In recent years, a broader approach to ...
Bedell Victoria M VM Department of Biochemistry and Molecular Biology, Mayo Clinic, Guggenheim 1321A, 200 1st Street South, Rochester, MN, 55905, - - 2015
Over the last few years, the technology to create targeted knockout and knockin zebrafish animals has exploded. We have gained the ability to create targeted knockouts through the use of zinc finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs) and clustered regularly interspaced short palindromic repeats/CRISPR associated system (CRISPR/Cas). Furthermore, ...
Lemus-Zúñiga Lenin-G LG Instituto ITACA, Universitat Politècnica de València , Universitat Politécnica de Valencia (UPV), Edificio 8G, Camino de Vera, S/N, 46022, València, Spain, - - 2015
Information technology (IT) and serious games allow older population to remain independent for longer. Hence, when designing technology for this population, developmental changes, such as attention and/or perception, should be considered. For instance, a crucial developmental change has been related to cognitive speed in terms of reaction time (RT). However, ...
Fernandez-Llatas Carlos C Instituto ITACA, Universitat Politècnica de València, València, Spain, - - 2015
The creation of tools supporting the automatization of the standardization and continuous control of healthcare processes can become a significant helping tool for clinical experts and healthcare systems willing to reduce variability in clinical practice. The reduction in the complexity of design and deployment of standard Clinical Pathways can enhance ...
Wilson-Kanamori John J School of Informatics, University of Edinburgh, Informatics Forum IF-5.30, 10 Crichton Street, Edinburgh, EH8 9AB, Scotland, UK, - - 2015
Rule-based modeling, an alternative to traditional reaction-based modeling, allows us to intuitively specify biological interactions while abstracting from the underlying combinatorial complexity. One such rule-based modeling formalism is Kappa, which we introduce to readers in this chapter. We discuss the application of Kappa to three modeling scenarios in synthetic biology: ...
Cooling Michael T MT Auckland Bioengineering Institute, University of Auckland, Uniservices House, Room 639, 70 Symonds Street, Auckland, New Zealand, - - 2015
Here three models for a simple genetic device are constructed using modular mathematical models. The models are stored in an online system (the Physiome Model Repository) with distributed source and access control, demonstrating a collaborative method for creating mathematical models from reusable components.
Choi Jae Woo JW Department of Dermatology, Seoul National University College of Medicine and Seoul National University Bundang Hospital, Seongnam, South - - 2014
The erythema, scale and thickness of psoriasis lesions could be converted to bioengineering parameters. An objective psoriasis severity assessment is advantageous in terms of accuracy and reproducibility over conventional severity assessment. We aimed to formulate an objective psoriasis severity index with a single bioengineering device that can possibly substitute the ...
Hordijk Wim W SmartAnalytiX.com, Lausanne, Switzerland, - - 2014
We provide a formal but visually clear example of how a set of minimal necessary conditions for evolvability of autocatalytic sets is satisfied in a simple model of chemical reaction systems. Furthermore, we show how these conditions can be captured and analyzed with RAF theory, and how the results can ...
Lee Dave C H DC The Faculty of Life Sciences, The Michael Smith Building, The University of Manchester, Oxford Road, Manchester, M13 9PT, - - 2014
Analysis of the phosphoproteome by mass spectrometry has become a key technology for the characterisation of dynamic regulatory processes in the cell, since kinase and phosphatase action underlie many major biological functions. However, the addition of a phosphate group to a suitable sidechain often confounds informatic analysis by generating product ...
Fitzpatrick Colin - - 2014
Recent legislation has focused attention on the supply chains of tin, tungsten, tantalum and gold (3TG), specifically those originating from the eastern part of the Democratic Republic of Congo. The unique properties of these so-called "conflict minerals" lead to their use in many products, ranging from medical devices to industrial ...
Lopes Oscar - - 2014
The use of depth maps is of increasing interest after the advent of cheap multisensor devices based on structured light, such as Kinect. In this context, there is a strong need of powerful 3-D shape descriptors able to generate rich object representations. Although several 3-D descriptors have been already proposed ...
Berolo Sophia S a Department of Kinesiology , University of Waterloo , Waterloo , - - 2014
ABSTRACT Objective: The purposes of this study were to: 1) examine agreement between self-reported measures of mobile device use and direct measures of use, and 2) understand how respondents thought about their device use when they provided self-reports. Methods: Self-reports of six categories of device use were obtained using a ...
Hicks Jennifer L - - 2014
Computational modeling and simulation of neuromusculoskeletal (NMS) systems enables researchers and clinicians to study the complex muscle and joint dynamics underlying human movement. NMS models use equations, derived from physical and biological laws, to bridge the gap between the real and the abstract and help solve challenging real-world problems, from ...
Zhang Ailin A Department of Engineering, University of Cambridge, Trumpington Street, Cambridge, CB2 1PZ, United - - 2014
The input admittance at the bridge, measured by hammer testing, is often regarded as the most useful and convenient measurement of the vibrational behavior of a bowed string instrument. However, this method has been questioned, due especially to differences between human bowing and hammer impact. The goal of the research ...
Johansen Mark K MK School of Psychology, Cardiff - - 2014
Two main uses of categories are classification and feature inference, and category labels have been widely shown to play a dominant role in feature inference. However, the nature of this influence remains unclear, and we evaluate two contrasting hypotheses formalized as mathematical models: the label special-mechanism hypothesis and the label ...
Keltie Kim - - 2014
Several authors have developed and applied methods to routine data sets to identify the nature and rate of complications following interventional procedures. But, to date, there has been no systematic search for such methods. The objective of this article was to find, classify and appraise published methods, based on analysis ...
Abedi Vida - - 2014
BackgroundThe data overload has created a new set of challenges in finding meaningful and relevant information with minimal cognitive effort. However designing robust and scalable knowledge discovery systems remains a challenge. Recent innovations in the (biological) literature mining tools have opened new avenues to understand the confluence of various diseases, ...
Mahmood Mohammad Nauzef MN University of Groningen, UMCG, Department of Rehabilitation Medicine, Groningen - The - - 2014
The aim of this work is to develop a tool to study the effect of sodium nitroprusside (SNP) on hemodynamics in conjunction with baroreflex and mechanical circulatory assistance. To this aim, a numerical model of the pharmacodynamic effect of SNP was developed and inserted into a cardiovascular circulatory model integrated ...
Baptista Neto A T AT Nuclear Technology Development Center - CDTN/CNEN, Av. Presidente Antônio Carlos, 6627 - Campus UFMG, Pampulha, Belo Horizonte 31270-901, MG, Brazil. Electronic address: - - 2014
In this work we compare the kVp estimate between CDTN multipurpose instrument, UnforsXI and Radcal 4075 meters under different combinations of voltage and filtration. The non-invasively measurements made using x-ray diagnostic and interventional radiology devices show similar tendencies to increase the kVp estimate when aluminum filters are placed in the ...
Pérez-Pérez Martín M ESEI - Escuela Superior de Ingeniería Informática, Edificio Politécnico, Campus Universitario As Lagoas s/n, Universidad de Vigo, 32004 Ourense, - - 2014
Document annotation is a key task in the development of Text Mining methods and applications. High quality annotated corpora are invaluable, but their preparation requires a considerable amount of resources and time. Although the existing annotation tools offer good user interaction interfaces to domain experts, project management and quality control ...
Xiang Bin B School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138; - - 2014
HCFC-22 (CHClF2) and HFC-134a (CH2FCF3) are two major gases currently used worldwide in domestic and commercial refrigeration and air conditioning. HCFC-22 contributes to stratospheric ozone depletion, and both species are potent greenhouse gases. In this work, we study in situ observations of HCFC-22 and HFC-134a taken from research aircraft over ...
Roldán Silvia S Instituto Nacional del Carbón, INCAR-CSIC, Apdo. 73, 33080-Oviedo, Spain. - - 2014
The proliferation of novel types and designs of electrochemical capacitors makes it necessary to obtain a better understanding of the behavior of these systems together with a more systematic classification of them. In this study a rational classification of supercapacitors based on the charge storage mechanism and the active material ...
Ravat Prince P Max Planck Institute for Polymer Research, Ackermannweg 10, 55128 Mainz, Germany. - - 2014
Our findings provide a better understanding of the discrepancies related to the discussion in the literature on the ground state of Tschitschibabin's hydrocarbon. A series of phenylene bridged bisnitroxide molecules were designed and studied for the comparison. The simple theoretical and experimental methodologies have been developed and utilized to understand ...
Zhang Yuting - - 2014
Gait, as a promising biometric for recognizing human identities, can be nonintrusively captured as a series of acceleration signals using wearable or portable smart devices. It can be used for access control. Most existing methods on accelerometer-based gait recognition require explicit step-cycle detection, suffering from cycle detection failures and intercycle ...
Griffith Richard R Swansea - - 2014
Although healthcare assistants (HCAs) are not registered practitioners, they are still accountable to a range of people who regulate their conduct.
Chesi Cristiano C IUSS - Institute for Advanced Study of Pavia, Piazza Vittoria 15, I-27100, Pavia, Italy, - - 2014
Minimalism in grammatical theorizing (Chomsky in The minimalist program. MIT Press, Cambridge, 1995) led to simpler linguistic devices and a better focalization of the core properties of the structure building engine: a lexicon and a free (recursive) phrase formation operation, dubbed Merge, are the basic components that serve in building ...
Li Siran S Lewis-Sigler Institute for integrative Genomics, Princeton University, Princeton, NJ 08544, USA. - - 2014
The nematode Caenorhabditis elegans (C. elegans) is an excellent model to study reproductive aging because of its short life span, its cessation of reproduction in mid-adulthood, and the strong conservation of pathways that regulate longevity. During its lifetime, a wild-type C. elegans hermaphrodite usually lays about 200-300 self-fertilized hatchable eggs, ...
Summers Jennifer A JA King's Technology Evaluation Centre, London, UK, - - 2014
The geko™ device is a single-use, battery-powered, neuromuscular electrostimulation device that aims to reduce the risk of venous thromboembolism (VTE). The National Institute for Health and Care Excellence (NICE) selected the geko™ device for evaluation, and invited the manufacturer, Firstkind Ltd, to submit clinical and economic evidence. King's Technology Evaluation ...
Wang Xiaopu X Department of Chemical Engineering, School of Engineering and Applied Science, University of Virginia, Charlottesville, VA, - - 2014
Chemotaxis has been shown to be beneficial for the migration of soil-inhabiting bacteria towards industrial chemical pollutants, which they degrade. Many studies have demonstrated the importance of this microbial property under various circumstances; however, few quantitative analyses have been undertaken to measure the two essential parameters that characterize the chemotaxis ...
Pibouleau Leslie L Univ Paris Diderot;Sorbonne Paris Cité;INSERM UMR 717;Hop Saint-Louis,Service de Biostatistique et information - - 2014
Rationale: Bayesian methods provide an interesting approach to assessing an implantable medical device (IMD) that has evolved through successive versions because they allow for explicit incorporation of prior knowledge into the analysis. However, the literature is sparse on the feasibility and reliability of elicitation in cases where expert beliefs are ...
Song Yeongtak Y 1 School of Electrical Engineering, University of Ulsan , Ulsan, - - 2014
Abstract Background: Although many smartphone application (app) programs provide education and guidance for basic life support, they do not commonly provide feedback on the chest compression depth (CCD) and rate. The validation of its accuracy has not been reported to date. This study was a feasibility assessment of use of ...
Carbonell-Ballestero Max M ICREA-Complex Systems Laboratory, Universitat Pompeu Fabra, 08003 Barcelona, Spain Institut de Biologia Evolutiva, CSIC-UPF, Psg. de la Barceloneta 37, 08003 Barcelona, - - 2014
Within the field of synthetic biology, a rational design of genetic parts should include a causal understanding of their input-output responses-the so-called transfer function-and how to tune them. However, a commonly adopted strategy is to fit data to Hill-shaped curves without considering the underlying molecular mechanisms. Here we provide a ...
Gao Hang H Lab on Cardiovascular Imaging and Dynamics, KU Leuven, Leuven, Belgium. Electronic address: - - 2014
Despite the availability of multiple ultrasound approaches to left ventricular (LV) flow characterization in two dimensions, this technique remains in its childhood and further developments seem warranted. This article describes a new methodology for tracking the 2-D LV flow field based on ultrasound data. Hereto, a standard speckle tracking algorithm ...
Tanaka Yoshiyuki - - 2014
This paper proposes a scheme for human force manipulability (HFM) based on the use of isometric joint torque properties to simulate the spatial characteristics of human operation forces at an end-point of a limb with feasible magnitudes for a specified limb posture. This is also applied to the evaluation/prediction of ...
Holmes Martin S MS 1 Trinity Centre for Bioengineering, Trinity College Dublin , Ireland - - 2014
Abstract Background: Dry powder inhaler (DPI) users frequently exhale into their inhaler mouthpiece before the inhalation step. This error in technique compromises the integrity of the drug and results in poor bronchodilation. This study investigated the effect of four exhalation factors (exhalation flow rate, distance from mouth to inhaler, exhalation ...
Dargar Saurabh - - 2014
We have developed an instrumented endoscope grip handle equipped with a 6-axis load cell and measured forces and torques during a simulated transgastric NOTES appendectomy procedure performed in an EASIE-R© ex vivo simulator. The data were collected from 10 participating surgeons of varying degrees of expertise which was analyzed to ...
Selby Edward A EA Rutgers, The State University of New - - 2014
Influenced by chaos theory, the Emotional Cascade Model proposes that rumination and negative emotion may promote each other in a self-amplifying cycle that increases over time. Accordingly, exponential-compounding effects may better describe the relationship between rumination and negative emotion when they occur in impulsive persons, and predict impulsive behavior. Participants ...
Montserrat A A Catalan Institute for Water Research (ICRA), Scientific and Technological Park, H20 Building, Emili Grahit 101, 17003, Girona, - - 2014
Using low-cost sensors, data can be collected on the occurrence and duration of overflows in each combined sewer overflow (CSO) structure in a combined sewer system (CSS). The collection and analysis of real data can be used to assess, improve, and maintain CSSs in order to reduce the number and ...
Hiremath Shivayogi V SV Department of Veterans Affairs, Human Engineering Research Laboratories, VA Pittsburgh Healthcare System, Pittsburgh, PA, United States; Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, PA, United - - 2014
Availability of physical activity monitors for wheelchair users can potentially assist these individuals to track regular physical activity (PA), which in turn could lead to a healthier and more active lifestyle. Therefore, the aim of this study was to develop and validate algorithms for a physical activity monitoring system (PAMS) ...
Weaver Abigail A AA Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN, 46556, USA, - - 2014
Paper-based devices serve to address many analytical questions both inside and outside of the laboratory setting. For the first time, yeast is used to construct a whole-cell, paper-based biosensor device. This biologically based paper analytical device (BioPAD) is sensitive to antibiotics in the tetracycline family, and it could potentially address ...
Ferros Isabel I *Department of Stomatology, Facultad de Medicina y Odontología, Universidad de Santiago de - - 2014
Summary INTRODUCTION: It is widely accepted that there is a relationship between the cranial base and the development of the nasomaxillary complex (NMC). The objective of the present study was to investigate the morphological relationship between these two anatomical units in skulls that have intentionally been subjected to one of ...
Godwin Zachary Z Department of Pathology and Laboratory Medicine, University of California Davis School of Medicine, United States. Electronic address: - - 2014
We have developed a novel software application that provides a simple and interactive Lund-Browder diagram for automatic calculation of total body surface area (TBSA) burned, fluid formula recommendations, and serial wound photography on a smart device platform. The software was developed for the iPad (Apple, Cupertino, CA) smart device platforms. ...
Fini Natalie A NA Department of Physiotherapy, La Trobe University , Melbourne , Australia - - 2014
Abstract Purpose: To describe how physical activity is monitored following stroke; to summarise methods and devices used across the stroke pathway and document their psychometric properties. Methods: Searches of five databases identified studies that included stroke survivors whose physical activity was quantitatively measured. Two reviewers independently determined inclusion. A descriptive ...
Cate David M - - 2014
Paper is a centuries old substrate for carrying out chemical measurements. The application of paper as a platform for microfluidics, however, was only introduced to the scientific community less than ten years ago and has become a major new field of research. Microfluidic paper-based analytical devices are attractive as sensors ...
Shi Yingzhong - - 2014
Recently, a time-adaptive support vector machine (TA-SVM) is proposed for handling nonstationary datasets. While attractive performance has been reported and the new classifier is distinctive in simultaneously solving several SVM subclassifiers locally and globally by using an elegant SVM formulation in an alternative kernel space, the coupling of subclassifiers brings ...
Eidels Ami A School of Psychology, University of Newcastle, Callaghan, New South Wales, 2308, Australia, - - 2014
This investigation brings together a response-time system identification methodology (e.g., Townsend & Wenger Psychonomic Bulletin & Review 11, 391-418, 2004a) and an accuracy methodology, intended to assess models of integration across stimulus dimensions (features, modalities, etc.) that were proposed by Shaw and colleagues (e.g., Mulligan & Shaw Perception & Psychophysics ...
Davidsohn Noah - - 2014
A long-standing goal of synthetic biology is to rapidly engineer new regulatory circuits from simpler devices. As circuit complexity grows, it becomes increasingly important to guide design with quantitative models, but previous efforts have been hindered by lack of predictive accuracy. To address this, we developed Empirical Quantitative Incremental Prediction ...
Beqiri Arian A Division of Imaging Sciences and Biomedical Engineering, King's College - - 2014
The use of electromagnetic (EM) modeling is critical for specific absorption rate (SAR) characterization in parallel transmission MRI. Radiofrequency arrays that include decoupling networks can be difficult to characterize accurately in simulation. A practical method of simplifying modeling is to exclude the decoupling networks and model each transmit element in ...
Fraiwan Arwa A Bioelectronics & Microsystems Laboratory, Department of Electrical & Computer Engineering, State University of New York-Binghamton, Binghamton, NY 13902, USA. - - 2014
Paper-based devices have recently emerged as simple and low-cost paradigms for fluid manipulation and analytical/clinical testing. However, there are significant challenges in developing paper-based devices at the system level, which contain integrated paper-based power sources. Here, we report a microfabricated paper-based bacteria-powered battery that is capable of generating power from ...
Li Ruo-Zhou - - 2014
Paper-based capacitive touch pads can be fabricated utilizing high concentration silver nanowire inks needle-printed directly onto paper substrates through a 2D programmable platform. Post deposition, silver nanowire tracks can be photonically sintered using a camera flash to reduce sheet resistance similar to thermal sintering approaches. Touch pad sensors on a ...
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