Search Results
Results 1 - 50 of 1249
1 2 3 4 5 6 7 8 9 10 >
Gómez-Outes Antonio A Division of Pharmacology and Clinical Evaluation, Department of Medicines for Human Use, Spanish Agency for Medicines and Medical Devices (AEMPS), Parque Empresarial "Las Mercedes", Edificio 8, C/Campezo 1, 28022, Madrid, Spain, - - 2014
Patients undergoing total hip replacement (THR) or total knee replacement (TKR) surgery are at high risk of developing venous thromboembolism (VTE). Thromboprophylaxis with low-molecular-weight heparin, such as enoxaparin, is standard of care in these patients. Recently, three direct oral anticoagulants (DOACs; dabigatran, rivaroxaban and apixaban), have been approved for this ...
Williams C D CD Oregon State University/Oregon Health and Science University College of Pharmacy, Portland, Oregon, - - 2014
New data solidify a "smoker's paradox" for clopidogrel, with current smokers appearing to respond better than nonsmokers. However, the clinical implications of this finding are unclear. This Commentary discusses the new data and puts it into clinical context.
Paz-Soldan Valerie A VA Global Health Systems and Development Department, Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana, United States of - - 2014
Quantifying human mobility has significant consequences for studying physical activity, exposure to pathogens, and generating more realistic infectious disease models. Location-aware technologies such as Global Positioning System (GPS)-enabled devices are used increasingly as a gold standard for mobility research. The main goal of this observational study was to compare and ...
Chalret du Rieu Quentin Q Clinical Pharmacokinetics Department, Institut de Recherches Internationales Servier, Suresnes, - - 2014
Background In the clinical development of oncology drugs, the recommended dose is usually determined using a 3 + 3 dose-escalation study design. However, this phase I design does not always adequately describe dose-toxicity relationships. Methods 125 patients, with either solid tumours or lymphoma, were included in the study and 1217 platelet counts ...
Zhao Qi Q State Key Laboratory of Biocontrol, School of Life Sciences, School of Advanced Computing, Sun Yat-sen University, Guangzhou 510275, - - 2014
Small ubiquitin-like modifiers (SUMOs) regulate a variety of cellular processes through two distinct mechanisms, including covalent sumoylation and non-covalent SUMO interaction. The complexity of SUMO regulations has greatly hampered the large-scale identification of SUMO substrates or interaction partners on a proteome-wide level. In this work, we developed a new tool ...
Pawęska Justyna - - 2014
Ticagrelor is the first reversibly binding oral P2Y12 receptor antagonist, made up for reduction of clinical thrombotic events in patients with acute coronary syndromes (ACS). Compared to clopidogrel ticagrelor was proved to significantly reduce the rate of death from vascular causes, myocardial infarction, or stroke without an increase in the ...
Hashidzume Akihito A Department of Macromolecular Science, Graduate School of Science, Osaka University, 1-1 Machikaneyama-cho, Toyonaka, Osaka, 560-0043, - - 2014
This chapter overviews molecular machines based on cyclodextrins (CDs). The categories of CD-based molecular machines, external stimuli for CD-based molecular machines, and typical examples of CD-based molecular machines are briefly described.
de Julian-Ortiz J Vicente - - 2014
Discerning between the concepts of difficulty and usefulness of a molecular ranking classification is of capital importance in virtual design chemistry. Here, both concepts are viewed from the statistical and practical point of view according to the standard definitions of enrichment and statistical significance p-values. These parameters are useful not ...
Geppert Tim - - 2014
Within this work a methodological extension of the matched molecular pair analysis is presented. The method is based on a pharmacophore retyping of the molecular graph and a consecutive matched molecular pair analysis. The features of the new methodology are exemplified using a large dataset on CYP inhibition. We show ...
Wittmann Marion E ME Department of Biological Sciences, University of Notre Dame , Notre Dame, Indiana 46556, United - - 2014
Recently, authors have theorized that invasive species prevention is more cost-effective than control in protecting ecosystem services. However, quantification of the effectiveness of prevention is rare because experiments at field scales are expensive or infeasible. We therefore used structured expert judgment to quantify the efficacy of 17 proposed strategies to ...
Md Saad R R Institute of Engineering Mathematics, Universiti Malaysia Perlis, Pauh Putra Main Campus, 02600 Arau, Perlis, - - 2014
Multicriteria decision making (MCDM) is one of the methods that popularly has been used in solving personnel selection problem. Alternatives, criteria, and weights are some of the fundamental aspects in MCDM that need to be defined clearly in order to achieve a good result. Apart from these aspects, fuzzy data ...
Kim Chongwon C School of Mechanical and Aerospace Engineering and the Institute of Advanced Aerospace Technology, Seoul National University, Daehak-dong, Kwanak-gu, Seoul 151-744, Korea. - - 2014
The ephemeris data format of legacy GPS receivers is improper for positioning stationary pseudolites on the ground. Therefore, to utilize pseudolites for navigation, GPS receivers must be modified so that they can handle the modified data formats of the pseudolites. Because of this problem, the practical use of pseudolites has ...
Berenger Francois F Zhang Initiative Research Unit, Institute Laboratories, RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198, - - 2014
Measures of similarity for chemical molecules have been developed since the dawn of chemoinformatics. Molecular similarity has been measured by a variety of methods including molecular descriptor based similarity, common molecular fragments, graph matching and 3D methods such as shape matching. Similarity measures are widespread in practice and have proven ...
- - 2014
[This corrects the article DOI: 10.1371/journal.pone.0098804.].
Hinsen Konrad - - 2013
The MOlecular SimulAtion Interchange Conventions (MOSAIC) consist of a data model for molecular simulations and of concrete implementations of this data model in the form of file formats. MOSAIC is designed as a modular set of specifications, of which the initial version covers molecular structure and configurations. A reference implementation ...
Tan Wen - - 2013
P-glycoprotein (P-gp) is an ATP-binding cassette multidrug transporter. The over expression of P-gp leads to the development of multidrug resistance (MDR), which is a major obstacle to effective treatment of cancer. Thus, designing effective P-gp inhibitors has an extremely important role in the overcoming MDR. In this paper, both ligand-based ...
Zhao Yuansheng - - 2013
In vitro inhibitory potency (Ki )-based predictions of P-glycoprotein (P-gp)-mediated drug-drug interactions (DDIs) are hampered by the substantial variability in inhibitory potency. In this study, in vivo-based [I]/Ki was utilized to predict the DDI risks of a P-gp substrate dabigatran etexilate (DABE) using physiologically based pharmacokinetic (PBPK) modeling. Digoxin (P-gp ...
Brummel-Ziedins Kathleen E - - 2013
Thrombin has multiple functions in blood coagulation and its regulation is central to maintaining the balance between hemorrhage and thrombosis. Empirical and computational methods that capture thrombin generation can provide advancements to current clinical screening of the hemostatic balance at the level of the individual. In any individual, procoagulant and ...
Shen Jibin - - 2013
Flavonoids, the most diverse class of plant secondary metabolites, exhibit high affinity toward the purified cytosolic NBD2(C-terminal nucleotide-binding domain) of P-glycoprotein (P-gp). To explore the affinity of flavonoids for P-gp, quantitative structure-activity relationships (QSARs) models were developed using back-propagation artificial neural networks (BPANN) and multiple linear regression (MLR). Molecular descriptors ...
Toropova Alla P AP IRCCS, Istituto di Ricerche Farmacologiche Mario Negri, 20156, Via La Masa 19, Milano, - - 2013
Methodology of building up and validation of models for carcinogenic potentials of drugs by means of the CORAL software is described. The QSAR analysis by the CORAL software includes three phases: (i) definition of preferable parameters for the optimization procedure that gives maximal correlation coefficient between endpoint and an optimal ...
Cresswell Lynne - - 2013
Objective: In randomised controlled trials of weight loss interventions, high dropout rates are a problem resulting in a large amount of missing outcome data. It is common for participants with missing data to be excluded from analysis (complete-case analysis). We aim to demonstrate how published complete-case results can be used ...
Legg David A - - 2013
The relationships of major arthropod clades have long been contentious, but refinements in molecular phylogenetics underpin an emerging consensus. Nevertheless, molecular phylogenies have recovered topologies that morphological phylogenies have not, including the placement of hexapods within a paraphyletic Crustacea, and an alliance between myriapods and chelicerates. Here we show enhanced ...
Gilboa Elad - - 2013
Exact Gaussian process (GP) regression has O(N^3) runtime for data size N, making it intractable for large N. Many algorithms for improving GP scaling approximate the covariance with lower rank matrices. Other work has exploited structure inherent in particular covariance functions, including GPs with implied Markov structure, and inputs on ...
Klepsch Freya - - 2013
The ABC transporter P-glycoprotein (P-gp) actively transports a wide range of drugs and toxins out of cells, and is therefore related to multidrug resistance and the ADME profile of therapeutics. Thus, development of predictive in silico models for the identification of P-gp inhibitors is of great interest in the field ...
Li Xingxing - - 2013
In recent times increasing numbers of high-rate GPS stations have been installed around the world and set-up to provide data in real-time. These networks provide a great opportunity to quickly capture surface displacements, which makes them important as potential constituents of earthquake/tsunami monitoring and warning systems. The appropriate GPS real-time ...
Schrago C G - - 2013
Recent methodological advances in molecular dating associated with the growing availability of sequence data have prompted the study of the evolution of New World Anthropoidea in recent years. Motivated by questions regarding historical biogeography or the mode of evolution, these works aimed to obtain a clearer scenario of Platyrrhini origins ...
Zhao Qi - - 2013
Bivalirudin, used in patients with heparin-induced thrombocytopenia, is a direct thrombin inhibitor. Since it is a rarely used drug, clinical experience with its dosing is sparse. We develop two approaches to predict the Partial Thromboplastin Time (PTT) based on bivalirudin infusion rates. The first approach is model-free and utilizes regularized ...
Ferraboschi Patrizia - - 2013
Argatroban (I), a potent noncovalent reversible thrombin inhibitor, is used as an anticoagulant for the parenteral treatment of heparin-induced thrombocytopenia (HIT) patients. By virtue of its pharmacological properties and the well-balanced risks and benefits, argatroban is now emerging as a clinically relevant antithrombotic agent. The availability of this drug as ...
Tantanate C - - 2013
Bleeding time is still widely performed in many developing countries including Thailand. To generate an accurate result, the procedure should be complied with standard recommendations such as those from Clinical and Laboratory Standards Institute (CLSI) and World Federation of Hemophilia (WFH). The authors surveyed the current practices of bleeding time ...
Bonduelle Colin - - 2013
Glycoproteins are naturally produced by protein glycosylation and are involved in a wide range of cellular functions. This review aims at summarizing the preparation of well-defined synthetic glycoproteins by using chemical routes as well as to highlight the preparation of ideal polymeric analogues of natural glycoproteins: glycopolypeptides. These macromolecules are ...
Hoeben Eef - - 2013
BACKGROUND AND OBJECTIVES: JNJ-37822681 is a selective, fast-dissociating dopamine D2-receptor antagonist currently in development as a candidate antipsychotic. The aim of the analyses was to develop a population pharmacokinetic model to describe the pharmacokinetics of JNJ-37822681 in healthy subjects and patients with schizophrenia and to identify covariates of interest. The ...
Chalret du Rieu Quentin - - 2013
PURPOSE: A population pharmacokinetic/pharmacodynamic (PK/PD) model was developed to describe the thrombocytopenia (dose-limiting toxicity) of abexinostat, a new histone deacetylase inhibitor. An optimal administration schedule of the drug was determined using a simulation-based approach. METHODS: Early PK and PK/PD data were analysed using a sequential population modeling approach (NONMEM 7), ...
Camus M - - 2013
Background and study aims: The management of upper gastrointestinal bleeding requires training of the endoscopist. We aimed to validate a live animal model of bleeding ulcers for training in endoscopic hemostasis.Materials and methods: Bleeding ulcers were created by repeated grasp-and-snare gastric mucosectomies in pigs rendered "bleeders" by preadministration of clopidogrel, ...
Fischer K - - 2013
The increasing attention to healthcare costs and treatment efficiency has led to an increasing demand for quantitative data concerning patient and treatment characteristics in haemophilia. However, most of these data are difficult to obtain. The aim of this study was to use expert judgement elicitation (EJE) to estimate currently unavailable ...
Daza Edgar E - - 2013
We present several procedures to represent molecular electrostatic potential as a graph, based on the pattern of critical points and their neighborhood relations. This representation is used for the comparison of the molecular electrostatic comparison, which is reduced to a comparison of tree-type graphs. Several methods to compare trees are ...
Schmitt Anne J - - 2013
INTRODUCTION: The purpose of this study was to monitor and to optimize heparinization during endovascular procedures in the New Zealand White Rabbit (NZWR) model. METHODS: Right common carotid artery aneurysms were surgically created in 43 NZWR, with an average weight of 4,330 g (range 3,500-5,430 g). The activated partial thromboplastin time (aPTT) ...
Mahmoudi Mandana - - 2013
INTRODUCTION: Major orthopedic surgery is associated with a high risk of venous thromboembolism (VTE). Anticoagulants are recommended to prevent VTE, and recently an oral direct factor Xa inhibitor (FXaI) was approved for this indication. We compared the cost-effectiveness of FXaIs with low-molecular-weight heparin (LMWH) in patients undergoing total hip replacement ...
Abe Sadahiro - - 2013
Objective: The aim of this study was to develop a novel population pharmacokinetic (PPK) model of dalteparin after subcutaneous (s.c.) injection, to describe the impact of the "flip-flop" phenomenon and to demonstrate any ethnic difference between Asian and Caucasian subjects. Materials and methods: The PPK model was constructed based on ...
Carbonell Pablo - - 2013
We present an algorithm to compute molecular graph descriptors considering the stereochemistry of the molecular structure, based on our previously introduced signature molecular descriptor. The algorithm can generate two types of descriptors, one which is compliant with the Cahn-Ingold-Prelog priority rules including for complex stereochemistry structures such as fullerenes, and ...
Middelburg R A - - 2013
INTRODUCTION: Bleeding is increasingly considered an important end point in clinical platelet transfusion studies. Accurate recording and adjudication into well-defined bleeding grades, however, remains a major challenge. METHODS: We developed a computer algorithm for automatic adjudication. The algorithm's results were compared to those of three independent adjudicators. RESULTS: For one ...
Thierry Benoit - - 2013
BACKGROUND: Health studies and mHealth applications are increasingly resorting to tracking technologies such as Global Positioning Systems (GPS) to study the relation between mobility, exposures, and health. GPS tracking generates large sets of geographic data that need to be transformed to be useful for health research. This paper proposes a ...
Theidel Ulrike - - 2013
The aim of this health economic analysis was to compare the cost-effectiveness of ticagrelor versus clopidogrel within the German health care system. A two-part decision model was adapted to compare treatment with ticagrelor or clopidogrel in a low-dose acetylsalicylic acid (ASA) cohort (≤150 mg) for all ACS patients and subtypes NSTEMI/IA ...
Yousef A M - - 2013
AIM: Clopidogrel is metabolized primarily into an inactive carboxyl metabolite (clopidogrel-IM) or to a lesser extent an active thiol metabolite. A population pharmacokinetic (PK) model was developed using NONMEM® to describe the time-course of clopidogrel-IM in plasma and design a sparse-sampling strategy to predict clopidogrel-IM exposures for use in characterizing ...
Chin C T - - 2013
Introduction: Ticagrelor is a novel antiplatelet drug developed to reduce atherothrombosis. The PLATO trial compared ticagrelor and aspirin to clopidogrel and aspirin in patients with acute coronary syndromes (ACS). Ticagrelor was found to be superior in the primary composite endpoint of cardiovascular death, myocardial infarction or stroke, without increasing major ...
Hongu Nobuko - - 2013
ABSTRACT:: Global positioning system (GPS) watches have been introduced commercially, converting frequent measurements of time, location, speed (pace), and elevation into energy expenditure (EE) estimates. The purpose of this study was to compare EE estimates of 4 different GPS watches (Forerunner, Suunto, Polar, Adeo) at various walking speeds, to EE ...
Van Connie - - 2013
BACKGROUND: Collaboration between general practitioners (GPs) and community pharmacists has been shown to be effective in improving patient outcomes. However, little is known about GP attitudes toward collaborating with their pharmacist counterparts and variables that influence this interprofessional collaboration. OBJECTIVES: To develop and validate, in the context of primary care in ...
Duncan Scott - - 2013
GPS receivers are becoming increasingly common as an objective measure of spatiotemporal movement in free-living populations; however, research into the effects of the surrounding physical environment on the accuracy of off-the-shelf GPS receivers is limited. The goal of the current study was to (1) determine the static validity of seven ...
Desai Prashant - - 2013
In silico tools are regularly utilized for designing and prioritizing compounds to address challenges related to drug metabolism and pharmacokinetics (DMPK) during the process of drug discovery. P-glycoprotein (P-gp) is a member of the ATP-binding cassette (ABC) transporters with broad substrate specificity that plays a significant role in absorption and ...
Karaboga Arnaud S - - 2013
Since 3D molecular shape is an important determinant of biological activity, designing accurate 3D molecular representations is still of high interest. Several chemoinformatic approaches have been developed to try to describe accurate molecular shapes. Here, we present a novel 3D molecular description, namely harmonic pharma chemistry coefficient (HPCC), combining a ...
Samuels Nicole - - 2013
As an increasing number of recombinant therapeutic glycoproteins are manufactured and investigated, the importance of their attached glycans is becoming more widely reported and understood. Regulatory agencies expect detailed "extended characterization" of the glycoprotein as well as routine, well-controlled "release assays" with specifications to be employed for quality control of ...
1 2 3 4 5 6 7 8 9 10 >