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- - 2014
[This corrects the article DOI: 10.1016/j.curtheres.2014.02.001.].
Li Liqi - - 2014
Identification of the recombination hot/cold spots is critical for understanding the mechanism of recombination as well as the genome evolution process. However, experimental identification of recombination spots is both time-consuming and costly. Developing an accurate and automated method for reliably and quickly identifying recombination spots is thus urgently needed. Here ...
Poret Arnaud A Novadiscovery, 60, avenue Rockefeller, 69008 Lyon, France; UMR CNRS 5558, 43, boulevard du 11-Novembre-1918, 69622 Villeurbanne cedex, France. Electronic address: - - 2014
Target identification aims at identifying biomolecules whose function should be therapeutically altered to cure the considered pathology. An algorithm for in silico target identification using Boolean network attractors is proposed. It assumes that attractors correspond to phenotypes produced by the modeled biological network. It identifies target combinations which allow disturbed ...
- - 2014
[This corrects the article DOI: 10.1371/journal.pcbi.1003861.].
- - 2014
[This corrects the article DOI: 10.1371/journal.pcbi.1003860.].
Akabua Elom E Department of Electrical and Computer Engineering, University of Louisville, Louisville, KY 40292, United States. Electronic address: - - 2014
The universal sequel to chronic kidney condition (CKD) is anemia. Patients of anemia have kidneys that are incapable of performing certain basic functions such as sensing of oxygen levels to secrete erythropoietin when red blood cell counts are low. Under such conditions, external administration of human recombinant erythropoietin (EPO) is ...
- - 2014
[This corrects the article DOI: 10.1192/pb.bp.113.045088.][This corrects the article DOI: 10.1192/pb.bp.113.044016.].
- - 2014
[This corrects the article DOI: 10.1371/journal.pcbi.1003826.].
- - 2014
[This corrects the article on p. 509 in vol. 8, PMID: 20019937.].
- - 2014
[This corrects the article on p. 618 in vol. 92.].
- - 2014
[This corrects the article on p. 210 in vol. 34, PMID: 24790908.].
- - 2014
[This corrects the article on p. 114-121 in vol. 53.].
- - 2014
[This corrects the article on p. 315 in vol. 19, PMID: 24949073.].
Nowak Stefan S Institut für Theoretische Physik, Universität zu Köln, Cologne, - - 2014
Identifying and quantifying the benefits of sex and recombination is a long-standing problem in evolutionary theory. In particular, contradictory claims have been made about the existence of a benefit of recombination on high dimensional fitness landscapes in the presence of sign epistasis. Here we present a comparative numerical study of ...
Sargolzaie Narjes N Department of Community Medicine, Zahedan University of Medical Sciences , Zahedan , Iran - - 2014
Abstract The most common differential diagnosis of β-thalassemia (β-thal) trait is iron deficiency anemia. Several red blood cell equations were introduced during different studies for differential diagnosis between β-thal trait and iron deficiency anemia. Due to genetic variations in different regions, these equations cannot be useful in all population. The ...
Schiviz Alexandra A Baxter Innovations GmbH, 1221, Vienna, - - 2014
The murine tail-tip bleeding model is widely used to measure bleeding time, blood loss, and survival after treatment [1-4]. Due to the considerable variation in data from these studies and thus the need for large sample sizes per group, and the incomparability of results from different laboratories, research groups have ...
Ghassemi Mohammad M MM Laboratory for Computational Physiology, Massachusetts Institute of Technology, E25-505, 77 Massachusetts Ave, Cambridge, 02139, MA, USA, - - 2014
To demonstrate a novel method that utilizes retrospective data to develop statistically optimal dosing strategies for medications with sensitive therapeutic windows. We illustrate our approach on intravenous unfractionated heparin, a medication which typically considers only patient weight and is frequently misdosed. We identified available clinical features which impact patient response ...
- - 2014
[This corrects the article on p. 273 in vol. 88, PMID: 20431791.].
- - 2014
[This corrects the article on p. e35 in vol. 19.].
- - 2014
[This corrects the article on p. 533 in vol. 92, PMID: 25110379.].
- - 2014
[This corrects the article on p. 295 in vol. 18, PMID: 24944921.].
Gómez-Outes Antonio A Division of Pharmacology and Clinical Evaluation, Department of Medicines for Human Use, Spanish Agency for Medicines and Medical Devices (AEMPS), Parque Empresarial "Las Mercedes", Edificio 8, C/Campezo 1, 28022, Madrid, Spain, - - 2014
Patients undergoing total hip replacement (THR) or total knee replacement (TKR) surgery are at high risk of developing venous thromboembolism (VTE). Thromboprophylaxis with low-molecular-weight heparin, such as enoxaparin, is standard of care in these patients. Recently, three direct oral anticoagulants (DOACs; dabigatran, rivaroxaban and apixaban), have been approved for this ...
Paz-Soldan Valerie A VA Global Health Systems and Development Department, Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana, United States of - - 2014
Quantifying human mobility has significant consequences for studying physical activity, exposure to pathogens, and generating more realistic infectious disease models. Location-aware technologies such as Global Positioning System (GPS)-enabled devices are used increasingly as a gold standard for mobility research. The main goal of this observational study was to compare and ...
Williams C D CD Oregon State University/Oregon Health and Science University College of Pharmacy, Portland, Oregon, - - 2014
New data solidify a "smoker's paradox" for clopidogrel, with current smokers appearing to respond better than nonsmokers. However, the clinical implications of this finding are unclear. This Commentary discusses the new data and puts it into clinical context.
Zhao Qi Q State Key Laboratory of Biocontrol, School of Life Sciences, School of Advanced Computing, Sun Yat-sen University, Guangzhou 510275, - - 2014
Small ubiquitin-like modifiers (SUMOs) regulate a variety of cellular processes through two distinct mechanisms, including covalent sumoylation and non-covalent SUMO interaction. The complexity of SUMO regulations has greatly hampered the large-scale identification of SUMO substrates or interaction partners on a proteome-wide level. In this work, we developed a new tool ...
Chalret du Rieu Quentin Q Clinical Pharmacokinetics Department, Institut de Recherches Internationales Servier, Suresnes, - - 2014
Background In the clinical development of oncology drugs, the recommended dose is usually determined using a 3 + 3 dose-escalation study design. However, this phase I design does not always adequately describe dose-toxicity relationships. Methods 125 patients, with either solid tumours or lymphoma, were included in the study and 1217 platelet counts ...
Pawęska Justyna - - 2014
Ticagrelor is the first reversibly binding oral P2Y12 receptor antagonist, made up for reduction of clinical thrombotic events in patients with acute coronary syndromes (ACS). Compared to clopidogrel ticagrelor was proved to significantly reduce the rate of death from vascular causes, myocardial infarction, or stroke without an increase in the ...
Hashidzume Akihito A Department of Macromolecular Science, Graduate School of Science, Osaka University, 1-1 Machikaneyama-cho, Toyonaka, Osaka, 560-0043, - - 2014
This chapter overviews molecular machines based on cyclodextrins (CDs). The categories of CD-based molecular machines, external stimuli for CD-based molecular machines, and typical examples of CD-based molecular machines are briefly described.
de Julian-Ortiz J Vicente - - 2014
Discerning between the concepts of difficulty and usefulness of a molecular ranking classification is of capital importance in virtual design chemistry. Here, both concepts are viewed from the statistical and practical point of view according to the standard definitions of enrichment and statistical significance p-values. These parameters are useful not ...
Geppert Tim - - 2014
Within this work a methodological extension of the matched molecular pair analysis is presented. The method is based on a pharmacophore retyping of the molecular graph and a consecutive matched molecular pair analysis. The features of the new methodology are exemplified using a large dataset on CYP inhibition. We show ...
- - 2014
[This corrects the article on p. 405 in vol. 37.].
Wittmann Marion E ME Department of Biological Sciences, University of Notre Dame , Notre Dame, Indiana 46556, United - - 2014
Recently, authors have theorized that invasive species prevention is more cost-effective than control in protecting ecosystem services. However, quantification of the effectiveness of prevention is rare because experiments at field scales are expensive or infeasible. We therefore used structured expert judgment to quantify the efficacy of 17 proposed strategies to ...
- - 2014
[This corrects the article DOI: 10.1371/journal.pone.0087555.].
Hentabli Hamza H Faculty of Computing, University Technology of Malaysia, 81310 Skudai, Johor, - - 2014
Molecular similarity is a pervasive concept in drug design. The basic idea underlying molecular similarity is the similar property principle, which states that structurally similar molecules will exhibit similar physicochemical and biological properties. In this paper, a new graph-based molecular descriptor (GBMD) is introduced. The GBMD is a new method ...
- - 2014
[This corrects the article DOI: 10.1371/journal.pone.0098804.].
- - 2014
[This corrects the article DOI: 10.1371/journal.pone.0100588.].
Berenger Francois F Zhang Initiative Research Unit, Institute Laboratories, RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198, - - 2014
Measures of similarity for chemical molecules have been developed since the dawn of chemoinformatics. Molecular similarity has been measured by a variety of methods including molecular descriptor based similarity, common molecular fragments, graph matching and 3D methods such as shape matching. Similarity measures are widespread in practice and have proven ...
Md Saad R R Institute of Engineering Mathematics, Universiti Malaysia Perlis, Pauh Putra Main Campus, 02600 Arau, Perlis, - - 2014
Multicriteria decision making (MCDM) is one of the methods that popularly has been used in solving personnel selection problem. Alternatives, criteria, and weights are some of the fundamental aspects in MCDM that need to be defined clearly in order to achieve a good result. Apart from these aspects, fuzzy data ...
- - 2014
[This corrects the article DOI: 10.1371/journal.pone.0107085.].
- - 2014
[This corrects the article on p. 591 in vol. 36, PMID: 23565005.].
Moreno Allison R AR Division of Science and Environmental Policy, California State University, Monterey Bay, Seaside, California, United States of - - 2014
Although iron is the fourth most abundant element in the Earth's crust, bioavailable iron limits marine primary production in about one third of the ocean. This lack of iron availability has implications in climate change because the removal of carbon dioxide from the atmosphere by phytoplankton requires iron. Using literature ...
- - 2014
[This corrects the article on p. 1305 in vol. 37, PMID: 25083010.].
- - 2014
[This corrects the article DOI: 10.1371/journal.pone.0103002.].
- - 2014
[This corrects the article DOI: 10.1371/journal.pone.0111018.].
- - 2014
[This corrects the article on p. 881 in vol. 37, PMID: 24790266.].
- - 2014
[This corrects the article DOI: 10.1371/journal.pone.0106747.].
Kim Chongwon C School of Mechanical and Aerospace Engineering and the Institute of Advanced Aerospace Technology, Seoul National University, Daehak-dong, Kwanak-gu, Seoul 151-744, Korea. - - 2014
The ephemeris data format of legacy GPS receivers is improper for positioning stationary pseudolites on the ground. Therefore, to utilize pseudolites for navigation, GPS receivers must be modified so that they can handle the modified data formats of the pseudolites. Because of this problem, the practical use of pseudolites has ...
- - 2014
[This corrects the article DOI: 10.1136/lupus-2014-000048.].
- - 2014
[This corrects the article on p. 959 in vol. 37, PMID: 24790275.].
- - 2014
[This corrects the article on p. 1209 in vol. 37, PMID: 25061249.].
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