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Aguiar M M Centro de Matemática e Aplicações Fundamentais da Universidade de - - 2014
SUMMARY Models describing dengue epidemics are parametrized on disease incidence data and therefore high-quality data are essential. For Thailand, two different sources of long-term dengue data are available, the hard copy data from 1980 to 2005, where hospital admission cases were notified, and the electronic files, from 2003 to the ...
Fritah Sabrina S NorLux Neuro-Oncology Laboratory, Department of Oncology, Centre de Recherche Public de la Santé (CRP-Santé), Luxembourg L-1526, - - 2014
The vast majority of the human transcriptome does not code for proteins. Advances in transcriptome arrays and deep sequencing are giving rise to a fast accumulation of large data sets, particularly of long noncoding RNAs (lncRNAs). Although it is clear that individual lncRNAs may play important and diverse biological roles, ...
Yang Tianyu - - 2014
Long term tracking is a challenging task for many applications. In this paper, we propose a novel tracking approach that can adapt various appearance changes such as illumination, motion, and occlusions, and owns the ability of robust reacquisition after drifting. We utilize a condensation-based method with an online support vector ...
Igne Benoît - - 2014
Changes in raw materials and process wear and tear can have significant effects on the prediction error of near-infrared calibration models. When the variability that is present during routine manufacturing is not included in the calibration, test, and validation sets, the long-term performance and robustness of the model will be ...
Fan Zhewen Z a PNC Bank , Pittsburgh , - - 2014
Abstract One of the most challenging aspects of the pharmaceutical development is the demonstration and estimation of chemical stability. It is imperative that pharmaceutical products be stable for two or more years. Long term stability studies are required to support such shelf life claim at registration. However, during drug development ...
Li Peng P School of Control Science and Engineering, Shandong University, 17923 Jingshi Road, Jinan, 250061, People's Republic of - - 2014
Complexity of heartbeat interval series is typically measured by entropy. Recent studies have found that sample entropy (SampEn) or fuzzy entropy (FuzzyEn) quantifies essentially the randomness, which may not be uniformly identical to complexity. Additionally, these entropy measures are heavily dependent on the predetermined parameters and confined to data length. ...
Tucker Edmonds Brownsyne B Department of Obstetrics and Gynecology, Indiana University School of - - 2014
Abstract Objective: To describe and compare estimates of neonatal morbidity and mortality communicated by neonatologists and obstetricians in simulated periviable counseling encounters. Methods: A simulation-based study of 16 obstetricians (OBs) and 15 neonatologists counseling standardized patients portraying pregnant women with ruptured membranes at 23 weeks gestation. Two investigators tabulated all ...
Ferguson Adam R AR Brain and Spinal Injury Center, Department of Neurological Surgery, University of California at San Francisco, San Francisco, California, - - 2014
The launch of the US BRAIN and European Human Brain Projects coincides with growing international efforts toward transparency and increased access to publicly funded research in the neurosciences. The need for data-sharing standards and neuroinformatics infrastructure is more pressing than ever. However, 'big science' efforts are not the only drivers ...
Worrall Philip P University of Westminster, 101 New Cavendish Street, N7100, London, W1W 6UW, UK, - - 2014
Long-term care (LTC) represents a significant and substantial proportion of healthcare spends across the globe. Its main aim is to assist individuals suffering with more or more chronic illnesses, disabilities or cognitive impairments, to carry out activities associated with daily living. Shifts in several economic, demographic and social factors have ...
Levin Lars-Åke LA Department of Medical and Health Sciences, Linköping University, Linköping, Sweden - - 2014
The purpose of this study was to estimate the cost-effectiveness of two screening methods for detection of silent AF, intermittent electrocardiogram (ECG) recordings using a handheld recording device, at regular time intervals for 30 days, and short-term 24 h continuous Holter ECG, in comparison with a no-screening alternative in 75-year-old ...
Jadejaroen Janya J Zoological Science Program, Department of Biology, Faculty of Science, Chulalongkorn University, Bangkok, 10330, - - 2014
Rhesus (Macaca mulatta) and long-tailed (M. fascicularis) macaques are the most commonly used non-human primate models for biomedical research, but it is difficult to identify these two species in the hybrid zone (15-20°N). In this work, we used morphological values obtained via photogrammetry to assess hybrids of rhesus and long-tailed ...
Lin Ching-Heng CH Institute of Biomedical Informatics, National Yang-Ming University, Taipei, - - 2014
Electronic medical records with encoded entries should enhance the semantic interoperability of document exchange. However, it remains a challenge to encode the narrative concept and to transform the coded concepts into a standard entry-level document. This study aimed to use a novel approach for the generation of entry-level interoperable clinical ...
Rybin Denis D Boston University, Biostatistics, Boston, MA, USA; Boston VA Research Institute, VA Boston Healthcare System, Boston, MA, - - 2014
Missing data pose a serious challenge to the integrity of randomized clinical trials, especially of treatments for prolonged illnesses such as schizophrenia, in which long-term impact assessment is of great importance, but the follow-up rates are often no more than 50%. Sensitivity analysis using Bayesian modeling for missing data offers ...
Tang Yongqiang - - 2014
Abstract A sample size formula is derived for negative binomial regression for the analysis of recurrent events, in which subjects can have unequal follow-up time. We obtain sharp lower and upper bounds on the required size, which is easy to compute. The upper bound is generally only slightly larger than ...
Heuberger Jules A A C JA Centre for Human Drug Research, PK/PD, Leiden, The Netherlands, - - 2014
Δ(9)-Tetrahydrocannobinol (THC), the main psychoactive compound of Cannabis, is known to have a long terminal half-life. However, this characteristic is often ignored in pharmacokinetic (PK) studies of THC, which may affect the accuracy of predictions in different pharmacologic areas. For therapeutic use for example, it is important to accurately describe ...
Gidoin Cindy C INRA, UR 629 Écologie des Forêts Méditerranéennes, F-84914, Avignon, - - 2014
1.Theories of species coexistence and invasion ecology are fundamentally connected and provide a common theoretical framework for studying the mechanisms underlying successful invasions and their ecological impacts. Temporal fluctuations in resource availability and differences in life-history traits between invasive and resident species are considered as likely drivers of the dynamics ...
Taguri Masataka M Department of Biostatistics and Epidemiology, Graduate School of Medicine, Yokohama City University, Yokohama, - - 2014
Recently, several authors have shown that natural direct and indirect effects (NDEs and NIEs) can be identified under the sequential ignorability assumptions, as long as there is no mediator-outcome confounder that is affected by the treatment. However, if such a confounder exists, NDEs and NIEs will generally not be identified ...
Nallan Himamshu Chari - - 2014
Drop-on-demand inkjet printing of functional inks has received a great deal of attention for realizing printed electronics, rapidly prototyped structures, and large area systems. While this method of printing promises high process speeds and minimal substrate contamination, the performance of this process is often limited by the rheological parameters of ...
Tenney Jeffrey R JR Division of Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, - - 2014
Magnetoencephalography (MEG) is used to guide intracranial electroencephalography (ICEEG) monitoring and determine areas for resection. The purpose of this retrospective cross-sectional study was to report our experience using dipole modeling/dipole scanning, current density reconstructions, and beam-forming methods in a large cohort of pediatric patients with intractable epilepsy. Source localization results ...
Harmanci Arif - - 2014
We present MUSIC, a signal processing approach for identification of enriched regions in ChIP-Seq data, available at music.gersteinlab.org. MUSIC first filters the ChIP-Seq read-depth signal for systematic noise from non-uniform mappability, which fragments enriched regions. Then it performs a multiscale decomposition, using median filtering, identifying enriched regions at multiple length ...
Taylor R W RW Department of Zoology, 203 Natural Sciences, Michigan State University, East Lansing, MI, - - 2014
Temporal variation in selection has long been proposed as a mechanism by which genetic variation could be maintained despite short-term strong directional selection and has been invoked to explain the maintenance of consistent individual differences in behaviour. We tested the hypothesis that ecological changes through time lead to fluctuating selection, ...
Grizzle R E RE School of Marine Science and Ocean Engineering, Jackson Estuarine Laboratory, University of New Hampshire, Durham, NH 03824, USA. Electronic address: - - 2014
The seafloor at an open ocean finfish aquaculture facility in the western Gulf of Maine, USA was monitored from 1999 to 2008 by sampling sites inside a predicted impact area modeled by oceanographic conditions and fecal and food settling characteristics, and nearby reference sites. Univariate and multivariate analyses of benthic ...
Tittensor Derek P DP United Nations Environment Programme World Conservation Monitoring Centre (UNEP-WCMC), 219 Huntingdon Road, Cambridge CB3 0DL, UK. Department of Biology, Dalhousie University, 1355 Oxford Street, Halifax, NS B3H 4R2, Canada. - - 2014
In 2010 the international community, under the auspices of the Convention on Biological Diversity, agreed on 20 biodiversity-related "Aichi Targets" to be achieved within a decade. We provide a comprehensive mid-term assessment of progress toward these global targets using 55 indicator data sets. We projected indicator trends to 2020 using ...
Flannelly Laura T LT a Center for Psychosocial Research , Massapequa , New York , - - 2014
This article begins by defining the term variable and the terms independent variable and dependent variable, providing examples of each. It then proceeds to describe and discuss synonyms for the terms independent variable and dependent variable, including treatment, intervention, predictor, and risk factor, and synonyms for dependent variable, such as ...
Prueitt Robyn L RL Gradient , Cambridge, MA , - - 2014
Abstract We conducted a weight-of-evidence (WoE) analysis to assess whether the current body of research supports a causal relationship between long-term ozone exposure (defined by EPA as at least 30 days in duration) at ambient levels and cardiovascular (CV) effects. We used a novel WoE framework based on the United ...
Lepais Olivier O INRA, UMR 1224, Ecologie Comportementale et Biologie des Populations de Poissons, Saint Pée sur Nivelle, F-64310, France; Univ Pau & Pays Adour, UMR 1224, Ecologie Comportementale et Biologie des Populations de Poissons, UFR Sciences et Techniques de la Côte Basque, Anglet, F-64600, - - 2014
Predicting likely species responses to an alteration of their local environment is key to decision-making in resource management, ecosystem restoration and biodiversity conservation practice in the face of global human-induced habitat disturbance. This is especially true for forest trees which are a dominant life form on Earth and play a ...
Wasserkampf A A Department of Health and Social Psychology, Institute of Psychology, German Sport University Cologne, Am Sportpark Müngersdorf 6, 50933 Cologne, Germany, Department of Health Promotion, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Center +, P.O. Box 616, 6200 MD Maastricht, The Netherlands and CIPER, Faculty of Human Kinetics, University of Lisbon, Estrada da Costa, Cruz Quebrada, 1495-688 Cruz-Quebrada, Portugal Department of Health and Social Psychology, Institute of Psychology, German Sport University Cologne, Am Sportpark Müngersdorf 6, 50933 Cologne, Germany, Department of Health Promotion, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Center +, P.O. Box 616, 6200 MD Maastricht, The Netherlands and CIPER, Faculty of Human Kinetics, University of Lisbon, Estrada da Costa, Cruz Quebrada, 1495-688 Cruz-Quebrada, - - 2014
This study analyzed psychosocial predictors of the Theory of Planned Behavior (TPB) and Self-Determination Theory (SDT) and evaluated their associations with short- and long-term moderate plus vigorous physical activity (MVPA) and lifestyle physical activity (PA) outcomes in women who underwent a weight-management program. 221 participants (age 37.6 ± 7.02 years) ...
Feinauer Christoph C DISAT and Center for Computational Sciences, Politecnico Torino, Torino, - - 2014
Correlation patterns in multiple sequence alignments of homologous proteins can be exploited to infer information on the three-dimensional structure of their members. The typical pipeline to address this task, which we in this paper refer to as the three dimensions of contact prediction, is to (i) filter and align the ...
Gerber Susanne S Institute of Computational Science, Università della Svizzera Italiana, 6900 Lugano, - - 2014
Discrete state models are a common tool of modeling in many areas. E.g., Markov state models as a particular representative of this model family became one of the major instruments for analysis and understanding of processes in molecular dynamics (MD). Here we extend the scope of discrete state models to ...
Dunstone Nick J NJ Hadley Centre, Met Office, Exeter EX1 3PB, UK - - 2014
Here, I examine some of the many varied ways in which sustained global ocean observations are used in numerical modelling activities. In particular, I focus on the use of ocean observations to initialize predictions in ocean and climate models. Examples are also shown of how models can be used to ...
Soni Kirti K CSIR-National Physical Laboratory, Delhi, India, - - 2014
A study of the assessment and management of air quality was carried out at 11 coal mines in India. Long-term observations (about 13 years, March 2000-December 2012) and modeling of aerosol loading over coal mines in India are analyzed in the present study. In this respect, the Box-Jenkins popular autoregressive integrated ...
McBride Paul D PD Institute for Applied Ecology New Zealand, School of Applied Science, Auckland University of Technology, Private Bag 92006, Auckland, New - - 2014
The relationship between net primary productivity and species richness has been the subject of long-running debate. A changing climate gives added impetus to resolving this debate, as it becomes increasingly necessary to predict biodiversity responses that might arise from shifts in productivity or its climatic correlates. It has become increasingly ...
Brown Tristan R TR Department of Forest and Natural Resources Management, SUNY-ESF, Syracuse, NY 13210, United States. Electronic address: - - 2014
Recent advances in the thermochemical processing of biomass have resulted in efforts to commercialize several cellulosic biofuel pathways. Until commercial-scale production is achieved, however, techno-economic analysis is a useful methodology for quantifying the economic competitiveness of these pathways with petroleum, providing one indication of their long-term feasibility under the U.S. ...
Brascamp Evert W EW Animal Breeding and Genomics Centre, Wageningen University, Wageningen, 6700 AH, The Netherlands. - - 2014
Efficient methodologies based on animal models are widely used to estimate breeding values in farm animals. These methods are not applicable in honey bees because of their mode of reproduction. Observations are recorded on colonies, which consist of a single queen and thousands of workers that descended from the queen ...
Kheifetz Yuri Y Institute for Medical Biomathematics (IMBM), POB 282, Hate'ena St. 10, 60991, Bene-Ataroth, - - 2014
Inflammation underlies many diseases and is an undesired effect of several therapy modalities. Biomathematical modeling can help unravel the complex inflammatory processes and the mechanisms triggering their emergence. We developed a model for induction of C-reactive protein (CRP), a clinically reliable marker of inflammation, by interleukin (IL)-11, an approved cytokine ...
Sun Tianhaozhe T School of Earth and Ocean Sciences, University of Victoria, Victoria, British Columbia V8P 5C2, - - 2014
After a large subduction earthquake, crustal deformation continues to occur, with a complex pattern of evolution. This postseismic deformation is due primarily to viscoelastic relaxation of stresses induced by the earthquake rupture and continuing slip (afterslip) or relocking of different parts of the fault. When postseismic geodetic observations are used ...
van de Koppel Johan J Department of Spatial Ecology, Royal Netherlands Institute for Sea Research, 4401 NT Yerseke, The Netherlands and Community and Conservation Ecology Group, University of Groningen, 9700 CC Groningen, The Netherlands; email: - - 2014
Mounting evidence indicates that spatial interactions are important in structuring coastal ecosystems. Until recently, however, most of this work has been focused on seemingly exceptional systems that are characterized by regular, self-organized patterns. In this review, we document that interactions that operate at long distances, beyond the direct neighborhood of ...
Wade H M HM Environmental Research Institute, North Highland College, University of the Highlands and Islands, Thurso, UK. Electronic address: - - 2014
Marine renewable energy developments (MREDs) are an increasing feature of the marine environment. Owing to the relatively small number of existing developments and the early stage of their associated environmental monitoring programmes, the effects of MREDs on seabirds are not fully known. Our ability to fully predict potential effects is ...
Raskob Wolfgang W Karlsruher Institut für Technologie (KIT), Eggenstein-Leopoldshafen, Hermann-von-Helmholtz-Platz 1, Eggenstein-Leopoldshafen, Germany - - 2014
The PREPARE project that started in February 2013 and will end at the beginning of 2016 aims to close gaps that have been identified in nuclear and radiological preparedness in Europe following the first evaluation of the Fukushima disaster. Among others, the project will address the review of existing operational ...
Ibrahim Mahmoud M MM The Berlin Institute for Medical Systems Biology at the Max Delbrück Center for Molecular Medicine Berlin-Buch, Robert Rössle Str. 10, Berlin 13125, - - 2014
Although peak finding in NGS datasets has been addressed extensively, there is no consensus on how to analyze and process biological replicates. Furthermore, most peak finders do not focus on accurate determination of enrichment site widths and are not widely applicable to different types of datasets. We developed JAMM (Joint ...
Mandli Aravinda R AR Department of Chemical Engineering, Indian Institute of Science, Bangalore, - - 2014
Understanding the growth behavior of microorganisms using modeling and optimization techniques is an active area of research in the fields of Biochemical Engineering and Systems Biology. In this paper, we propose a general modeling framework, based on Monod model, to model the growth of microorganisms. Utilizing the general framework, we ...
Ma Jun - - 2014
Short-term synaptic facilitation occurs during high frequency stimulation, is known to be dependent on presynaptic calcium ions, and persists for tens of milliseconds after a presynaptic action potential. We have used the frog neuromuscular junction as a model synapse for both experimental and computer simulation studies aimed at testing various ...
De Luca Carlo J CJ Boston University - - 2014
Over the past four decades, various methods have been implemented to measure synchronization of motor unit firings. In this work we provide evidence that prior reports of the existence of universal common inputs to all motoneurons and the presence of long-term synchronization are misleading because they did not use sufficiently ...
Mou Weimin W University of Alberta, Canada. Electronic address: - - 2014
This project examined the roles of idiothetic cues due to individuals' movement and allothetic cues independent of individuals' movement in individuals' estimations of their position and heading during locomotion. In an immersive virtual environment, participants learned the locations of five objects and then moved along two legs of a path ...
Schwantes C R CR Department of Chemistry, Stanford University, Stanford, California 94305, - - 2014
Molecular dynamics simulations have the potential to provide atomic-level detail and insight to important questions in chemical physics that cannot be observed in typical experiments. However, simply generating a long trajectory is insufficient, as researchers must be able to transform the data in a simulation trajectory into specific scientific insights. ...
Fowler Sarah S Sarah Fowler, BSc, RN, Research Nurse, Bristol Urological Institute, Southmead Hospital, Bristol, United Kingdom. Helen Godfrey, PhD, RN, Principal Lecturer, Faculty of Health & Life Sciences, University of West of England, Bristol, United Kingdom. Mandy Fader, PhD, RN, Professor of Continence Technology, Faculty of Health Sciences, University of Southampton, United Kingdom. Anthony Gerard Timoney, MCh, FRCSEd, FRCSI, Consultant Urological Surgeon, Southmead Hospital, Bristol, United Kingdom. Adele Long, MBA, MPhil, BSc, Director of BUI Biomed, Bristol Urological Institute, Southmead Hospital, Bristol, United - - 2014
The purpose of this study was to explore the experiences of long-term catheter users within a heterogeneous population. The sample comprised 27 community-dwelling long-term catheter users. Participants included 14 female users (4 urethral, 10 suprapubic catheter) and 13 male users (6 urethral, 7 suprapubic) between 22 and 96 years of ...
Chatterjee Krishnendu K IST Austria, Klosterneuburg, - - 2014
A fundamental question in biology is the following: what is the time scale that is needed for evolutionary innovations? There are many results that characterize single steps in terms of the fixation time of new mutants arising in populations of certain size and structure. But here we ask a different ...
Kimball Kenneth D KD Research Department, Appalachian Mountain Club, 361 Route 16, Gorham, New Hampshire 03581 - - 2014
• Most alpine plants in the Northeast United States are perennial and flower early in the growing season, extending their limited growing season. Concurrently, they risk the loss of reproductive efforts to late frosts. Quantifying long-term trends in northeastern alpine flower phenology and late-spring/early-summer frost risk is limited by a ...
Zhang Jin J Key Laboratory of Water Pollution control and Wastewater Resource, Anhui Province, School of Environment and Energy Engineering, Anhui Jianzhu University, Hefei, PR - - 2014
Concentration addition (CA) is commonly used as a standard additive reference model to predict the short-term toxicity for most chemical mixtures. Whether CA can predict the long-term toxicity of antibiotic mixtures was investigated. The long-term toxicity of five antibiotics including apramycin sulfate, paromomycin sulfate, tetracycline hydrochloride, chloramphenicol and streptomycin sulfate ...
Sirkka Marianne M Department of Health Sciences, Luleå University of Technology , Luleå , - - 2014
Abstract Objective: The purpose of this qualitative descriptive study was to describe how long-term improvement work based on the Occupational Therapy Intervention Process Model (OTIPM) evolved in an occupational therapy unit. Method: Data included written documents related to the improvement work (435 pages in total) from 2001 to 2013 that ...
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