Search Results
Results 1 - 50 of 2259
1 2 3 4 5 6 7 8 9 10 >
Russell David J DJ Ophthalmology, Navy Medical Center San Diego, 34800 Bob Wilson Dr., San Diego, CA, 92134, United States - - 2014
Purpose. Develop a model for the CIRRUSTM HD-OCT that allows for the comparison of retinal nerve fiber layer (RNFL) thickness measurements with dissimilar signal strengths (SS) and accounts for test-re-test variability. Methods. RNFLs were obtained in normals using the CIRRUSTM optic disc cube 200x200 protocol during a single encounter. Five ...
Lei Fumin F Key Laboratory of Zoological Systematics and Evolution, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, - - 2014
Little has been published to describe or interpret Asian biodiversity hotspots, especially the East Himalaya - Mountains of Southwest China (H-MSC) range, thus making necessary a review based on the current knowledge. The Pliocene and Pleistocene geological and glacial histories of the Asian continent is different from those of Europe ...
Siegal-Gaskins Jennifer M JM Division of Physics, Mathematics, and Astronomy, California Institute of Technology, Pasadena, CA 91125 - - 2014
Indirect searches for products of dark matter annihilation and decay face the challenge of identifying an uncertain and subdominant signal in the presence of uncertain backgrounds. Two valuable approaches to this problem are (i) using analysis methods which take advantage of different features in the energy spectrum and angular distribution ...
Warszawski Shira S Department of Biological Chemistry, Weizmann Institute of Science, Rehovot 76100, - - 2014
To carry out their activities biological macromolecules balance different physical traits, such as stability, interaction affinity, and selectivity. How such often-opposing traits are encoded in a macromolecular system is critical to our understanding of evolutionary processes and ability to design new molecules with desired functions. We present a framework for ...
Leung Nelson L C NL Department of Chemistry, Institute for Advanced Study, Institute of Molecular Functional Materials, Division of Biomedical Engineering, Division of Life Science and State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon (Hong - - 2014
Aggregation-induced emission (AIE) has been harnessed in many systems through the principle of restriction of intramolecular rotations (RIR) based on mechanistic understanding from archetypal AIE molecules such as tetraphenylethene (TPE). However, as the family of AIE-active molecules grows, the RIR model cannot fully explain some AIE phenomena. Here, we report ...
Liang Cheng-Yen CY Department of Mechanical and Aerospace Engineering, University of California, Los Angeles, California 90095, - - 2014
Micromagnetic simulations of magnetoelastic nanostructures traditionally rely on either the Stoner-Wohlfarth model or the Landau-Lifshitz-Gilbert (LLG) model, assuming uniform strain (and/or assuming uniform magnetization). While the uniform strain assumption is reasonable when modeling magnetoelastic thin films, this constant strain approach becomes increasingly inaccurate for smaller in-plane nanoscale structures. This paper ...
Floridi Luciano L Oxford Internet Institute, University of Oxford, 1 St Giles, Oxford, OX1 3JS, UK, - - 2014
One of the pressing challenges we face today-in a post-Westphalian order (emergence of the state as the modern, political information agent) and post-Bretton Woods world (emergence of non-state multiagent systems or MASs as "hyperhistorical" players in the global economy and politics)-is how to design the right kind of MAS that ...
Wodarz Dominik D Department of Ecology and Evolutionary Biology and Department of Mathematics, University of California, 321 Steinhaus Hall, Irvine, CA, 92617, USA, - - 2014
T cell responses are a crucial part of the adaptive immune system in the fight against infections. This article discusses the use of mathematical models for understanding the dynamics of cytotoxic T lymphocyte (CTL) responses against viral infections. Complementing experimental research, mathematical models have been very useful for exploring new ...
Wang Ran - - 2014
A key issue in decision tree (DT) induction with continuous valued attributes is to design an effective strategy for splitting nodes. The traditional approach to solving this problem is adopting the candidate cut point (CCP) with the highest discriminative ability, which is evaluated by some frequency based heuristic measures. However, ...
van Heerwaarden B B School of Biological Sciences, Monash University, Clayton, Vic., - - 2014
Phenotypic plasticity may be an important initial mechanism to counter environmental change, yet we know relatively little about the evolution of plasticity in nature. Species with widespread distributions are expected to have evolved higher levels of plasticity compared with those with more restricted, tropical distributions. At the intraspecific level, temperate ...
Chakraborty Saikat S Department of Chemical Engineering, Indian Institute of Technology, Kharagpur 721302, India. Electronic address: - - 2014
This multiscale three-zone reactive mixing model provides a theoretical framework for engineering a scale separation in batch enzymatic hydrolysis of cellulose to strategize significant leaps in glucose yields. Formulated using the Liapunov-Schmidt method of the classical bifurcation theory, our model explores the multiscale spatiotemporal dynamics between the fundamental processes of ...
Deift Percy A PA Courant Institute, New York University, New York, NY 10012; - - 2014
The authors present evidence for universality in numerical computations with random data. Given a (possibly stochastic) numerical algorithm with random input data, the time (or number of iterations) to convergence (within a given tolerance) is a random variable, called the halting time. Two-component universality is observed for the fluctuations of ...
Kamiya T T Laboratoire MIVEGEC (UMR CNRS 5290, UR IRD 224, UM1, UM2), 911 avenue Agropolis, BP 64501, 34394, Montpellier Cedex 5, - - 2014
Sexual selection hypotheses stipulate that the Major Histocompatibility Complex genes (MHC) constitute a key molecular underpinning for mate choice in vertebrates. The last four decades saw growing empirical literature on the role of MHC diversity and dissimilarity in mate choice for a wide range of vertebrate animals, but with mixed ...
Dorsch Glauber C GC Department of Physics and Astronomy, University of Sussex, BN1 9QH Brighton, United - - 2014
Quantum scale invariance in the UV has been recently advocated as an attractive way of solving the gauge hierarchy problem arising in the standard model. We explore the cosmological signatures at the electroweak scale when the breaking of scale invariance originates from a hidden sector and is mediated to the ...
Lee David C DC School of Applied Sciences, University of South Wales, Pontypridd, United Kingdom; RSPB Centre for Conservation Science, Royal Society for the Protection of Birds, Sandy, United - - 2014
All gibbon species are globally threatened with extinction yet conservation efforts are undermined by a lack of population and ecological data. Agile gibbons (Hylobates agilis) occur in Sumatra, Indonesia and adjacent mainland Southeast Asia. Population densities are known from four sites (three in Sumatra) while little is known about their ...
Alicea Bradly B Orthogonal Research, Champaign, IL 61821, USA. Electronic address: - - 2014
Many models have been used to simplify and operationalize the subtle but complex mechanisms of biological evolution. Toy models are gross simplifications that nevertheless attempt to retain major essential features of evolution, bridging the gap between empirical reality and formal theoretical understanding. In this paper, we examine thirteen models which ...
Hong Bonnie - - 2014
Compositional analysis is a requisite component of the substantial equivalence framework utilized to assess genetically modified (GM) crop safety. Statistical differences in composition data between GM and non-GM crops require a context in which to determine biological relevance. This context is provided by surveying the natural variation of key nutrient ...
Fergus Thomas A TA Baylor University, USA. Electronic address: - - 2014
Difficulties tolerating uncertainty are considered central to scrupulosity, a moral/religious presentation of obsessive-compulsive disorder (OCD). We examined whether uncertainty salience (i.e., exposure to a state of uncertainty) caused fears of sin and fears of God, as well as whether priming God concepts affected the impact of uncertainty salience on those ...
Bright Aimée K - - 2014
Across a range of domains in psychology different theories assume different mental representations of knowledge. For example, in the literature on category-based inductive reasoning, certain theories (e.g., Rogers & McClelland, 2004; Sloutsky & Fisher, 2008) assume that the knowledge upon which inductive inferences are based is associative, whereas others (e.g., ...
Hidalgo-Galiana Amparo - - 2014
BackgroundSpecies thermal requirements are one of the principal determinants of their ecology and biogeography, although our understanding of the interplay between these factors is limited by the paucity of integrative empirical studies. Here we use empirically collected thermal tolerance data in combination with molecular phylogenetics/phylogeography and ecological niche modelling to ...
Zheng Minghao M Research Center for Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, 132 East Circle at University City, Guangzhou, 510006, - - 2014
Abundant data on compound bioactivity and publicly accessible chemical databases increase opportunities for ligand-based drug discovery. In order to make full use of the data, an online platform for ligand-based virtual screening (LBVS) using publicly accessible databases has been developed. LBVS adopts Bayesian learning approach to create virtual screening models ...
Atias Nir N Blavatnik School of Computer Science, Tel Aviv University, Tel Aviv 69978, - - 2014
A holy grail of biological research is a working model of the cell. Current modeling frameworks, especially in the protein-protein interaction domain, are mostly topological in nature, calling for stronger and more expressive network models. One promising alternative is logic-based or Boolean network modeling, which was successfully applied to model ...
Sébillot Anthony A WatchFrog S.A., 1 rue Pierre Fontaine, 91000 Evry, - - 2014
Widespread environmental antiandrogen contamination has been associated with negative impacts on biodiversity and human health. In particular, many pesticides are antiandrogenic, creating a need for robust and sensitive environmental monitoring. Our aim was to develop a sensitive and specific transgenic medaka (Oryzias latipes) model bearing an androgen responsive fluorescent reporter ...
Hino Yasumichi Y Construction Safety Research Group, National Institute of Occupational Safety and Health, - - 2014
Many fatal accidents due to falls from heights have occurred at construction sites not only in Japan but also in other countries. This study aims to determine the fall prevention performance of two types of safety belts: a body belt(1)), which has been used for more than 40 yr in the ...
Lever Melissa M Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, Oxfordshire OX1 3RE, - - 2014
T cell activation is a crucial checkpoint in adaptive immunity, and this activation depends on the binding parameters that govern the interactions between T cell receptors (TCRs) and peptide-MHC complexes (pMHC complexes). Despite extensive experimental studies, the relationship between the TCR-pMHC binding parameters and T cell activation remains controversial. To ...
Beauchamp Guy G Faculty of Veterinary Medicine, University of Montreal, PO Box 5000, St Hyacinthe, Québec, Canada J2S 7C6 - - 2014
In many ecological situations, resources are difficult to find but become more apparent to nearby searchers after one of their numbers discovers and begins to exploit them. If the discoverer cannot monopolize the resources, then others may benefit from joining the discoverer and sharing their discovery. Existing theories for this ...
García-Pérez Guillermo G Departament de Física Fonamental, Universitat de Barcelona, Martí i Franquès 1, 08028 Barcelona, - - 2014
Natural numbers can be divided in two nonoverlapping infinite sets, primes and composites, with composites factorizing into primes. Despite their apparent simplicity, the elucidation of the architecture of natural numbers with primes as building blocks remains elusive. Here, we propose a new approach to decoding the architecture of natural numbers ...
Martinez-Vaquero Luis A LA Grupo Interdisciplinar de Sistemas Complejos (GISC), Departamento de Matemáticas, Universidad Carlos III de Madrid, 28911 Leganés, Madrid, - - 2014
When a population is engaged in successive prisoner's dilemmas, indirect reciprocity through reputation fosters cooperation through the emergence of moral and action rules. A simplified model has recently been proposed where individuals choose between helping others or not and are judged good or bad for it by the rest of ...
Arbiser Samuel S Luis Agote 2437, 2°, C.A.B.A., Argentina. - - 2014
This article presents, in the author's own vision, his attempt to consider (and update) the work of an original thinker of contemporary psychoanalysis (in the present). Following a short overview of his biographical data and distinctive traits as maestro and man, it then tries to capture the implications and panoramic ...
Milligan Scott - - 2014
Scholars disagree over whether Islam hinders the development of liberal democracy in Muslim-majority countries. We contribute to this debate by assessing the influence of Islam at the individual and national levels on ethnic, racial, and religious tolerance in 23 countries. Our analyses are based on a set of multilevel models ...
Perez André Coura AC Fundação Arnaldo Vieira de Carvalho, Faculdade de Ciências Médicas da Santa Casa de São Paulo (FCMSCSP), São Paulo, SP, Brazil; Faculdade de Medicina de Ribeirão Preto (FMRP), Universidade de São Paulo (USP), Ribeirão Preto, SP, - - 2014
In order to better understand the pathophysiology of rhinosinusitis, several attempts have been made to create the disease in an animal model. Among the studied rodents each has its advantages and disadvantages. Rabbits are considered more appropriate for studies that require surgical manipulation or invasive procedures. To evaluate the most ...
Ríos-Touma Blanca - - 2014
Score-based biotic indices are widely used to evaluate the water quality of streams and rivers. Few adaptations of these indices have been done for South America because there is a lack of knowledge on macroinvertebrate taxonomy, distribution and tolerance to pollution in the region. Several areas in the Andes are ...
Cont Arshia A STMS 9912-CNRS, UPMC, Inria MuTant Team-Project, IRCAM, 1 Pl. Igor Stravinsky, Paris 75004, France, - - 2014
A system capable of undertaking automatic musical accompaniment with human musicians should be minimally able to undertake real-time listening of incoming music signals from human musicians, and synchronize its own actions in real-time with that of musicians according to a music score. To this, one must also add the following ...
Cosentino Stefano S Ear Institute, University College London, London, United - - 2014
A model is presented that predicts the binaural advantage to speech intelligibility by analyzing the right and left recordings at the two ears containing mixed target and interferer signals. This auditory-inspired model implements an equalization-cancellation stage to predict the binaural unmasking (BU) component, in conjunction with a modulation-frequency estimation block ...
Li Hui H Laboratory of Granular Computing, Minnan Normal University, Zhangzhou 363000, - - 2014
Rough set theory provides an effective tool to deal with uncertain, granular, and incomplete knowledge in information systems. Matroid theory generalizes the linear independence in vector spaces and has many applications in diverse fields, such as combinatorial optimization and rough sets. In this paper, we construct a matroidal structure of ...
Siswanto Waluyo Adi WA 0000-0002-2877-3916 Department of Engineering Mechanics, Universiti Tun Hussein Onn Malaysia, Parit Raja, Batu Pahat, 86400 Johor, - - 2014
The aim of this work is to improve the accuracy of cold stamping product by accommodating springback. This is a numerical approach to improve the accuracy of springback analysis and die compensation process combining the displacement adjustment (DA) method and the spring forward (SF) algorithm. This alternate hybrid method (HM) ...
Hasegawa Takanori T Bioinformatics Center, Institute for Chemical Research, Kyoto University, Uji, Kyoto, - - 2014
Comprehensive understanding of gene regulatory networks (GRNs) is a major challenge in the field of systems biology. Currently, there are two main approaches in GRN analysis using time-course observation data, namely an ordinary differential equation (ODE)-based approach and a statistical model-based approach. The ODE-based approach can generate complex dynamics of ...
Kuepfer Lars L Applied Microbiology, RWTH Aachen University, Worringer Weg 1, Room 42A/114, Aachen, 52074, Germany, - - 2014
Stoichiometric models describe cellular biochemistry with systems of linear equations. The models which are fundamentally based on the steady-state assumption are comparatively easy to construct and can be applied to networks up to genome scale. Fluxes are inherent variables in stoichiometric models and linear optimization can be used to identify ...
Chen X X Pharmacokinetics, Dynamics, and Metabolism, Pfizer Inc, Cambridge, Massachusetts, - - 2014
A mechanistic, multiscale mathematical model of immunogenicity for therapeutic proteins was built by recapitulating key underlying known biological processes for immunogenicity. The model is able to simulate immune responses based on protein-specific antigenic properties (e.g., number of T-epitopes and their major histocompatibility complex (MHC)-II binding affinities) and host-specific immunological/physiological characteristics ...
Chen X X Pharmacokinetics, Dynamics, and Metabolism, Pfizer Inc, Cambridge, Massachusetts, - - 2014
A mechanistic, multiscale mathematical model of immunogenicity for therapeutic proteins was formulated by recapitulating key biological mechanisms, including antigen presentation, activation, proliferation, and differentiation of immune cells, secretion of antidrug antibodies (ADA), as well as in vivo disposition of ADA and therapeutic proteins. This system-level model contains three scales: a ...
Selvarajoo Kumar K Institute for Advanced Biosciences, Keio University, Tsuruoka, Yamagata, Japan ; Systems Biology Program, Graduate School of Media and Governance, Keio University, Fujisawa, - - 2014
Cellular response such as cell signaling is an integral part of information processing in biology. Upon receptor stimulation, numerous intracellular molecules are invoked to trigger the transcription of genes for specific biological purposes, such as growth, differentiation, apoptosis or immune response. How complex are such specialized and sophisticated machinery? Computational ...
Marrella Veronica V Milan Unit, Institute of Genetics and Biomedic Research, National Research Council , Milan , Italy ; Istituto Clinico Humanitas, Istituto di Ricovero e Cura a Carattere Scientifico , Rozzano , - - 2014
[This corrects the article on p. 259 in vol. 5, PMID: 25076946.].
Hayes Sarah H SH Center for Hearing and Deafness, Department of Communicative Disorders and Sciences, University at Buffalo, The State University of New York , Buffalo, NY , - - 2014
The phantom perception of tinnitus and reduced sound-level tolerance associated with hyperacusis have a high comorbidity and can be debilitating conditions for which there are no widely accepted treatments. One factor limiting the development of treatments for tinnitus and hyperacusis is the lack of reliable animal behavioral models of these ...
Barbosa D H G S DH Embrapa Mandioca e Fruticultura, Núcleo de Recursos Genéticos e Desenvolvimento de Variedades, Cruz das Almas, BA, - - 2014
In view of the predicted models of global climate change and differences in prices and production costs, there is increased interest in Coffea canephora cultivation in areas of high altitude. However, this species is sensitive to low temperatures, where genotypes vary regarding adaptation/tolerance mechanisms, demonstrating genotype x environment interaction. The ...
Jeong WoonSeong W 0000-0003-0210-8464 Architecture Department, Texas A&M University, College Station, TX 77843, - - 2014
This paper presents a new approach to translate between Building Information Modeling (BIM) and Building Energy Modeling (BEM) that uses Modelica, an object-oriented declarative, equation-based simulation environment. The approach (BIM2BEM) has been developed using a data modeling method to enable seamless model translations of building geometry, materials, and topology. Using ...
Leifer M S MS Faculty of Philosophy, University of Oxford, 10 Merton Street, Oxford, OX1 4JJ, United - - 2013
We examine the relationship between quantum contextuality (in both the standard Kochen-Specker sense and in the generalized sense proposed by Spekkens) and models of quantum theory in which the quantum state is maximally epistemic. We find that preparation noncontextual models must be maximally epistemic, and these in turn must be ...
Lei Jing J Department of Statistics, Carnegie Mellon University Pittsburgh, PA - - 2013
This paper introduces a new approach to prediction by bringing together two different nonparametric ideas: distribution free inference and nonparametric smoothing. Specifically, we consider the problem of constructing nonparametric tolerance/prediction sets. We start from the general conformal prediction approach and we use a kernel density estimator as a measure of ...
Milton Sarah L SL Department of Biological Sciences, Florida Atlantic University, 777 Glades Road, Boca Raton, FL 33431, - - 2013
While the mammalian brain is highly dependent on oxygen, and can withstand only a few minutes without air, there are both vertebrate and invertebrate examples of anoxia tolerance. One example is the freshwater turtle, which can withstand days without oxygen, thus providing a vertebrate model with which to examine the ...
Wiesmann T - - 2012
BACKGROUND: Models for ultrasound-guided regional anaesthesia (USGRA) are important for research and training. However, the limited data available show great differences in quality of needle and tissue visualisation with regard to the applied model. This study aims to compare common USGRA models and human tissue with regard to their influence ...
Carbone V - - 2012
Subject-specific musculo-skeletal models of the lower extremity are an important tool for investigating various biomechanical problems, for instance the results of surgery such as joint replacements and tendon transfers. The aim of this study was to assess the potential effects of errors in musculo-skeletal geometry on subject-specific model results. We ...
1 2 3 4 5 6 7 8 9 10 >