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Lauseker Michael M Institut für medizinische Informationsverarbeitung, Biometrie und Epidemiologie, Ludwig-Maximilians-Universität, Marchioninistr. 15, 81377, München, Germany, - - 2014
Multi-state models support prediction in medicine. With different states of disease, chronic myeloid leukaemia (CML) is particularly suited for the application of multi-state models. In this article, we tried to find a model for CML that allows predicting the prevalence of three different states (initial state of disease, remission and ...
Limone Brendan L BL Evidence-Based Practice Center, Hartford Hospital, 80 Seymour Street, Hartford, CT 06102, USA; University of Connecticut School of Pharmacy, 69 North Eagleville Road, Storrs, CT 06102, - - 2014
Decision makers use models to assist in evaluating the cost-effectiveness of pharmacologic stroke prevention in atrial fibrillation (SPAF). We performed a search of databases through October 3, 2012 to identify pharmacologic SPAF cost-effectiveness models. Of 30 identified models, 28 included warfarin, but only 60% assessed the impact of warfarin control ...
Shallice Tim T a Institute of Cognitive Neuroscience , University College London , London , - - 2014
The article is concerned with inferences from the behaviour of neurological patients to models of normal function. It takes the letter-by-letter reading strategy common in pure alexic patients as an example of the methodological problems involved in making such inferences that compensatory strategies produce. The evidence is discussed on the ...
LaBonte Michelle L ML Department of Biological Sciences, Wellesley College, 106 Central Street, Wellesley, MA 02481, USA. Electronic address: - - 2014
Since its initial discovery in the 1940s, factor V has long been viewed as an important procoagulant protein in the coagulation cascade. However, in the later part of the 20th century, two different scientists proposed novel anticoagulant roles for factor V. Philip Majerus proposed the first anticoagulant function for factor ...
Brummel-Ziedins Kathleen E KE University of Vermont, Department of Biochemistry, 208 South Park Drive, Colchester, Vermont 05446. Electronic address: - - 2014
Global assays and computational models have advanced research into the realm of individualized profiling of hemostatic states. This brief review will describe one computational approach which utilizes an integrated method that evaluates the dynamics of thrombin generation by defining interactions of the pro and anticoagulant proteins, enzymes and cofactors based ...
Monroe Dougald M DM University of North Carolina Division of Hematology/Oncology, Chapel Hill, NC, USA; Duke University Department of Pathology, Durham, NC, USA. Electronic address: - - 2014
New oral anticoagulants to reduce the incidence of thrombosis have recently become available. When compared to the existing therapy, warfarin, these novel agents have similar efficacy with a reduced risk of spontaneous bleeding. However, these novel agents have been associated with significant, even fatal, bleeding following trauma. Reversal agents are ...
Bizerea Spiridon Otilia O Department of Biology-Chemistry, West University of Timisoara, 16 Pestalozzi, Timisoara, 300115, - - 2014
This letter is a response to the issues put forth by Dr. Y.S. Ho with regard to the article "Phenol removal from wastewater by adsorption on zeolitic composite" as reported by Bizerea Spiridon et al. (Environ Sci Pollut Res 20:6367-6381, 2013). The response proposes to clarify the error slipped in ...
Nielsen Peter Brønnum PB Thrombosis Research Unit, Aalborg University, Aalborg, Denmark. Electronic address: - - 2014
Warfarin is the most widely prescribed vitamin K antagonist and in the United States and Europe more than 10million people are currently in long-term oral anticoagulant treatment. This study aims to retrospectively validate a dynamic statistical model providing dosage suggestions to patients in warfarin treatment. The model was validated on ...
Freeth Tony T Antikythera Mechanism Research Project, South Ealing, London, United Kingdom; Images First Ltd, South Ealing, London, United - - 2014
The ancient Greek astronomical calculating machine, known as the Antikythera Mechanism, predicted eclipses, based on the 223-lunar month Saros cycle. Eclipses are indicated on a four-turn spiral Saros Dial by glyphs, which describe type and time of eclipse and include alphabetical index letters, referring to solar eclipse inscriptions. These include ...
Oken Barry S BS 1Oregon Health & Science University, Portland, OR, - - 2013
. Some noninvasive brain-computer interface (BCI) systems are currently available for locked-in syndrome (LIS) but none have incorporated a statistical language model during text generation. . To begin to address the communication needs of individuals with LIS using a noninvasive BCI that involves rapid serial visual presentation (RSVP) of symbols ...
Tollefsen Dag - - 2013
This letter develops a Bayesian focalization approach for three-dimensional localization of an unknown number of sources in shallow water with uncertain environmental properties. The algorithm minimizes the Bayesian information criterion using adaptive hybrid optimization for environmental parameters, Metropolis sampling for source bearing, and Gibbs sampling for source ranges and depths. ...
Awad Nadia I - - 2013
Prothrombin complex concentrate (PCC) products are emerging as alternative strategies for reversing anticoagulant pharmacotherapy. Factor eight inhibitor bypassing activity (FEIBA, or anti-inhibitor coagulant complex) is an activated PCC (aPCC). Although FEIBA is approved by the FDA to control spontaneous bleeding episodes and to prevent bleeding with surgical interventions in hemophilia ...
Rognoni Carla - - 2013
Non-valvular atrial fibrillation (NVAF) increases the risk of systemic thromboembolic events; therefore, anticoagulant treatment with vitamin K antagonists is widely prescribed. Recently, new oral anticoagulants (NOAs) directly inhibiting thrombin (dabigatran) or factor Xa (rivaroxaban and apixaban) demonstrated their non-inferiority with respect to warfarin in reducing the thromboembolic risk. The aim ...
Dickneite G - - 2013
Newer oral anticoagulants offer several advantages over traditional agents (e.g. warfarin), but they are still associated with a bleeding risk and currently there is no validated reversal treatment for them. While there is little support for the use of fresh frozen plasma, and limited data available on the effects of ...
Orhan Umut - - 2013
Objective. We aim to increase the symbol rate of electroencephalography (EEG) based brain-computer interface (BCI) typing systems by utilizing context information. Approach. Event related potentials (ERP) corresponding to a stimulus in EEG can be used to detect the intended target of a person for BCI. This paradigm is widely utilized ...
Meyer Rachel S - - 2013
The purpose of the study "Phylogeographic relationships among Asian eggplants and new perspectives on eggplant domestication" by Meyer et al (2012) was to use new and expanded accession sets coupled with molecular data to evaluate possible scenarios of eggplant domestication with as little influence as possible from any previously published ...
Lalanne Jean-Benoît - - 2013
Many biological networks have to filter out useful information from a vast excess of spurious interactions. In this Letter, we use computational evolution to predict design features of networks processing ligand categorization. The important problem of early immune response is considered as a case study. Rounds of evolution with different ...
Panarese Joseph D - - 2013
In this Letter, we describe a short, 6-step enantioselective route to spiroaminal lactam model systems reminiscent of marineosins A and B has been developed starting from either (R)- or (S)-hydroxysuccinic acid, respectively, in ~9% overall yield. This route enables late stage incorporation of the pyrrole ring at C5 via nucleophilic ...
Liang Faming - - 2013
Simulating from distributions with intractable normalizing constants has been a long-standing problem in machine learning. In this letter, we propose a new algorithm, the Monte Carlo Metropolis-Hastings (MCMH) algorithm, for tackling this problem. The MCMH algorithm is a Monte Carlo version of the Metropolis-Hastings algorithm. It replaces the unknown normalizing ...
Dosso Stan E - - 2013
This letter develops a Bayesian approach to matched-field tracking of multiple acoustic sources in a poorly-known environment. Markov-chain Monte Carlo methods explicitly sample the posterior probability density over source locations and environmental parameters, while analytic maximum-likelihood solutions for complex source strengths and noise variance in terms of the explicit parameters ...
Shinohara Russell T - - 2013
Parsimony is important for the interpretation of causal effect estimates of longitudinal treatments on subsequent outcomes. One method for parsimonious estimates fits marginal structural models by using inverse propensity scores as weights. This method leads to generally large variability that is uncommon in more likelihood-based approaches. A more recent method ...
Lauer Arne A Department of Neurology, Johann Wolfgang Goethe-University, 60526 Frankfurt am Main, - - 2013
Little is known about the pathophysiology of intracerebral haemorrhage that occurs during anticoagulant treatment. In observational studies, investigators have reported larger haematoma volumes and worse functional outcome in these patients than in those with intracerebral haemorrhage and a normal coagulation status. The need to prevent extensive haematoma enlargement by rapid ...
Perry Conrad - - 2013
It is often assumed that graphemes are a crucial level of orthographic representation above letters. Current connectionist models of reading, however, do not address how the mapping from letters to graphemes is learned. One major challenge for computational modeling is therefore developing a model that learns this mapping and can ...
Nielsen Peter Brønnum - - 2013
Patients with an increased risk of thrombosis may require treatment with vitamin K-antagonists such as warfarin. Treatment with warfarin has been reported difficult mainly due to high inter- and intraindividual variability in response to the drug [1]. Using predictive models that can predict International Normalised Ratio (INR) values enables for ...
Nshimyumukiza Léon - - 2013
Atrial fibrillation (AF) is the most common form of heart arrhythmia and a leading cause of stroke and systemic embolism. Chronic anticoagulation is recommended for preventing those complications. Our study aimed to compare the cost/utility (CU) of three main anticoagulation options: 1) standard warfarin dosing (SD-W) 2) warfarin dosage under ...
Limone Brendan L BL Department of Pharmacy Practice, University of Connecticut School of Pharmacy, Storrs, Connecticut, United States of - - 2013
To conduct a systematic review of economic models of newer anticoagulants for stroke prevention in atrial fibrillation (SPAF). We searched Medline, Embase, NHSEED and HTA databases and the Tuft's Registry from January 1, 2008 through October 10, 2012 to identify economic (Markov or discrete event simulation) models of newer agents ...
Brodić Darko D Technical Faculty in Bor, University of Belgrade, Vojske Jugoslavije 12, 19210 Bor, - - 2013
ANY DOCUMENT IN SERBIAN LANGUAGE CAN BE WRITTEN IN TWO DIFFERENT SCRIPTS: Latin or Cyrillic. Although characteristics of these scripts are similar, some of their statistical measures are quite different. The paper proposed a method for the extraction of certain script from document according to the occurrence and co-occurrence of ...
Kubitza Dagmar D Clinical Pharmacology, Bayer HealthCare AG Wuppertal, - - 2013
Direct oral anticoagulants that target a single coagulation factor (such as factor Xa or thrombin) have been developed in recent years in an attempt to address some of the limitations of traditional anticoagulants. Rivaroxaban is an oral, direct factor Xa inhibitor that inhibits free and clot-bound factor Xa and factor ...
O'Brien Michael J MJ Department of Mathematics, University of California at Los Angeles, Los Angeles, CA 90095, USA. - - 2013
In this letter, a novel critic-like algorithm was developed to extend the synaptic plasticity rule described in Florian (2007) and Izhikevich (2007) in order to solve the problem of learning multiple distal rewards simultaneously. The system is augmented with short-term plasticity (STP) to stabilize the learning dynamics, thereby increasing the ...
Szwed Marcin - - 2012
Letter-position tolerance varies across languages. This observation suggests that the neural code for letter strings may also be subtly different. Although language-specific models remain useful, we should endeavor to develop a universal model of reading acquisition which incorporates crucial neurobiological constraints. Such a model, through a progressive internalization of phonological ...
Berteau J-Ph - - 2012
In Adolescent Idiopathic Scoliosis (AIS), numerical models can enhance orthopaedic or surgical treatments and provide reliable insights into the mechanism of progression. Computational methods require knowledge of relevant parameters, such as the specific geometrical or material properties of the AIS rib, about which there is currently a lack of information. ...
Cutts Rosalind J RJ Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, - - 2012
High-throughput profiling has generated massive amounts of data across basic, clinical and translational research fields. However, open source comprehensive web tools for analysing data obtained from different platforms and technologies are still lacking. To fill this gap and the unmet computational needs of ongoing research projects, we developed O-miner, a ...
Olderøy Magnus O - - 2012
Alginate hydrogels have applications in biomedicine, ranging from delivery of cells and growth factors to wound management aids. However, they are mechanically soft and have shown little potential for the use in bone tissue engineering. Here, the viscoelastic properties of alginate hydrogel beads mineralized with calcium phosphate, both by a ...
Van Schepdael A - - 2012
Orthodontic tooth movement is achieved by the process of repeated alveolar bone resorption on the pressure side and new bone formation on the tension side. In order to optimize orthodontic treatment, it is important to identify and study the biological processes involved. This article presents a mechanobiological model using partial ...
Cerveri Pietro - - 2012
The results of recent studies concerning statistical bone atlases and automated shape analysis are promising with a view to widening the use of surface models in orthopedic clinical practice, both in pre-operative planning and in the intra-operative stages. In this domain, automatic shape analysis is strongly advocated because it offers ...
Lurie Alan - - 2012
The aim of this study was to demonstrate that histogram analysis and mathematical modeling of digital panoramic images (DPIs) processed using recursive hierarchic segmentation (RHSEG) discriminates normal, osteopenic, and osteoporotic cancellous bone. Forty-seven DPIs of postmenopausal women were grouped into normal, osteopenic, and osteoporotic; dual-energy x-ray absorptiometry was the reference ...
Hiess Joe - - 2012
The present-day (238)U/(235)U ratio has fundamental implications for uranium-lead geochronology and cosmochronology. A value of 137.88 has previously been considered invariant and has been used without uncertainty to calculate terrestrial mineral ages. We report high-precision (238)U/(235)U measurements for a suite of uranium-bearing minerals from 58 samples representing a diverse range ...
Kavukcuoglu N Beril NB Department of Bioengineering, Temple University, Philadelphia, PA 19122, - - 2012
Pseudoxanthoma elasticum (PXE) is a heritable multisystem disorder characterized by ectopic mineralization. However, the structure of the mineral deposits, their interactions with the connective tissue matrix, and the details of the progressive maturation of the mineral crystals are currently unknown. In this study, we examined the mineralization processes in Abcc6(-/-) ...
Pazzaglia Ugo E UE Orthopaedic Clinic, University of Brescia, Brescia, Italy. - - 2012
The kinetics of osteogenic cells within secondary osteons have been examined within a 2-D model. The linear osteoblast density of the osteons and the osteocyte lacunae density were compared with other endosteal lamellar systems of different geometries. The cell density was significantly greater in the endosteal appositional zone and was ...
Klimova Anna - - 2012
The paper considers general multiplicative models for complete and incomplete contingency tables that generalize log-linear and several other models and are entirely coordinate free. Sufficient conditions of the existence of maximum likelihood estimates under these models are given, and it is shown that the usual equivalence between multinomial and Poisson ...
Kuo Shih-Ya - - 2012
Although many repeat victimization studies have focused on describing the prevalence of the phenomenon, this study attempted to explain variations in the concentration of victimization by applying routine activities as a theoretical model. A multivariate analysis of repeat victimization based on the 2005 Taiwan criminal victimization data supported the general ...
Cassis G - - 2012
The Miridae, a hyperdiverse family containing more than 11,020 valid described species, are discussed and the pertinent literature is reviewed. Diagnoses for the family and subfamilies are given. Color habitus photos are presented for representatives of most of the 35 currently recognized tribes. Key morphological character systems are discussed and ...
Pérez-Garrido Alfonso - - 2012
In the last decades phenolic compounds have gained enormous interest because of their beneficial health effects such as anti-inflammatory, anticancer, or antiviral activities. The pharmacological effects of phenolic compounds are mainly due to their antioxidant activity and their inhibition of certain enzymes. This antoxidant activity is related to the structure ...
Cajee Na'eel A - - 2012
By examining Islam's jurisprudential literature about oral hygiene, this paper traces the scholarly discussions of jurists in the years after the Prophet Muhammad's passing until the present day. While previous inquiries into this subject have focused on the novelty of the Prophet's use of a tooth-stick, the focus of this ...
Overman Allen R - - 2012
[This corrects the article on p. e28515 in vol. 6.].
Pang Ka-Lai - - 2012
In the Halosphaeriaceae, taxa with unfurling ascospore appendages and related species constitute 61 species (in 21 genera). Recent phylogenetic analyses of the rRNA genes have advanced our knowledge on the relationships between genera in the family, especially the group with unfurling ascospore appendages. However, many new genera resulting from these ...
Greenberg Charles H - - 2012
The mechanism for hemorrhage enlargement in the brain, a key determinant of patient outcome following hemorrhagic stroke, is unknown. We performed computer-based stochastic simulation of one proposed mechanism, in which hemorrhages grow in "domino" fashion via secondary shearing of neighboring vessel segments. Hemorrhages were simulated by creating an initial site ...
Zhou Xiaoying - - 2012
During the process of matrix vesicle (MV)-mediated initiation of mineralisation, chondrocytes and osteoblasts mineralise the extracellular matrix by promoting the seeding of basic calcium phosphate crystals of hydroxyapatite (HA) along the collagen fibrils. This orchestrated process is carefully regulated by the balanced action of propagators and inhibitors of calcification. The ...
Löw K - - 2011
Parkinson's disease is a neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons in the substantia nigra. While sporadic in the majority of cases, PD-linked dominant mutations in the α-synuclein and LRRK-2 genes, and recessive mutations in the parkin, DJ-1 and PINK-1 genes have been identified in PD families ...
Abu Almakarem Amal S - - 2012
Base triples are recurrent clusters of three RNA nucleobases interacting edge-to-edge by hydrogen bonding. We find that the central base in almost all triples forms base pairs with the other two bases of the triple, providing a natural way to geometrically classify base triples. Given 12 geometric base pair families ...
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