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Bonnechère B B a Laboratory of Anatomy, Biomechanics and Organogenesis (LABO) , Université Libre de Bruxelles , Brussels , - - 2014
The recent availability of the Kinect™ sensor, a low-cost Markerless Motion Capture (MMC) system, could give new and interesting insights into ergonomics (e.g. the creation of a morphological database). Extensive validation of this system is still missing. The aim of the study was to determine if the Kinect™ sensor can ...
Eng Kevin H KH Roswell Park Cancer Institute, Department of Biostatistics and Bioinformatics, Elm and Carlton Streets, Buffalo, NY, 14263, - - 2014
We describe a novel study design for validating marker-based treatment strategies meant to select among possible therapeutic options using a biologic marker. Studying existing designs in realistic scenarios, we demonstrate that this design is more than four times more efficient for testing the interaction between a marker and its intended ...
Hens Koen - - 2014
Abstract Background: Six Sigma metrics were used to assess the analytical quality of automated clinical chemistry and immunoassay tests in a large Belgian clinical laboratory and to explore the importance of the source used for estimation of the allowable total error. Clinical laboratories are continually challenged to maintain analytical quality. ...
Lippi Giuseppe G Laboratory of Clinical Chemistry and Hematology, Academic Hospital of Parma , Parma , - - 2014
The laboratory assessment of cardiospecific troponins(s) represents the cornerstone for the diagnosis of acute coronary syndrome (ACS). Although troponin immunoassays are classified according to either analytical imprecision or percentage of measurable values in a presumably healthy population, it is rather clear that the nomenclature of commercial methods according to these ...
Aubry Anne-Françoise AF Analytical & Bioanalytical Development, Bristol-Myers Squibb, Princeton, NJ 08540, - - 2014
The last 10 years have witnessed robust debate within the bioanalytical community and regulatory authorities on the topic of metabolite monitoring and safety assessment. Of particular interest to regulated bioanalytical laboratories was the acceptance by the US FDA and other major regulatory bodies of a tiered approach to bioanalytical assay ...
Tsoi Jennifer J Department of Molecular & Medical Pharmacology, Crump Institute for Molecular Imaging, University of California, Los Angeles, CA 90095, USA. - - 2014
Background: Design of experiments (DOE) is utilized in optimizing ligand-binding assay by modeling factor effects. To reduce the analyst's workload and error inherent with DOE, we propose the integration of automated liquid handlers to perform the randomized designs. Results: A randomized design created from statistical software was imported into custom ...
Brulé Mathieu M State Institute of Agricultural Engineering and Bioenergy, University of Hohenheim, Stuttgart, Germany, - - 2014
Biochemical methane potential assays, usually run in batch mode, are performed by numerous laboratories to characterize the anaerobic degradability of biogas substrates such as energy crops, agricultural residues, and organic wastes. Unfortunately, the data obtained from these assays lacks common, universal bases for comparison, because standard protocols did not diffuse ...
Karajan N N Institute of Applied Mechanics (Civil Engineering), University of Stuttgart, Pfaffenwaldring 7, Stuttgart, 70569, Germany, - - 2014
A possibility to simulate the mechanical behaviour of the human spine is given by modelling the stiffer structures, i.e. the vertebrae, as a discrete multi-body system (MBS), whereas the softer connecting tissue, i.e. the softer intervertebral discs (IVD), is represented in a continuum-mechanical sense using the finite-element method (FEM). From ...
Teunis Marc A T MA University of Applied Sciences, Utrecht, The - - 2014
This study describes the international ring trial of the epidermal-equivalent (EE) sensitizer potency assay. This assay does not distinguish a sensitizer from a non-sensitizer, but may classify known skin sensitizers according to their potency. It assesses the chemical concentration resulting in 50% cytotoxicity (EE-EC50) or the 2-fold increase in IL-1α ...
Osis Sean T ST a Faculty of Kinesiology, University of Calgary , Calgary , - - 2014
As biomechanical research evolves, a continuing challenge is the standardization of data collection and analysis techniques. In gait analysis, placement of markers to construct an anatomical model has been identified as the single greatest source of error; however, there is currently no standardized approach to quantifying these errors. The current ...
Wang J J Institute of Zoology, Zoological Society of London, London, - - 2014
Inbreeding (F) of and relatedness (r) between individuals are now routinely calculated from marker data in studies in the fields of quantitative genetics, conservation genetics, forensics, evolution and ecology. Although definable in terms of either correlation coefficient or probability of identity by descent (IBD) relative to a reference, they are ...
Brainard Benjamin M BM Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, University of Georgia, Athens, GA - - 2014
To systematically examine the evidence on nontraditional uses of viscoelastic coagulation monitoring in veterinary species. Standardized, systematic evaluation of the literature, categorization of relevant articles according to level of evidence and quality, and development of consensus on conclusions for application of the concepts to clinical practice. Academic and referral veterinary ...
Hsu Man-Jen - - 2014
A biomarker is usually used as a diagnostic or assessment tool in medical research. Finding an ideal biomarker is not easy and combining multiple biomarkers provides a promising alternative. Moreover, some biomarkers based on the optimal linear combination do not have enough discriminatory power. As a result, the aim of ...
García-Cortés L A LA Departamento de Mejora Genética Animal, INIA, Madrid, - - 2014
The genetic relationship among individuals at one locus is characterized by nine coefficients of identity. The coefficients of inbreeding, coancestry and dominance (or fraternity) are just linear functions of them. Here, it is shown how they can be estimated using biallelic and triallelic markers using the method of moments, and ...
Basketter David A DA From the *DABMEB Consultancy Ltd, Sharnbrook, Bedford, UK; †L'Oréal Research & Innovation, Aulnay Sous Bois, France; ‡Shiseido Co, Ltd, Quality Assurance Center, Kanagawa, Japan; §Cosmetics Europe, The Personal Care Association, Brussels, Belgium; ∥Unilever, Safety and Environmental Assurance Centre, Bedford, Sharnbrook, United Kingdom; ¶The Procter & Gamble Company, Darmstadt, Germany; #Chanel, Neuilly sur Seine, France; **Seh Consulting + Services, Paderborn, Germany; ††The Procter & Gamble Company, Strombeek Bever, Belgium; ‡‡Henkel AG & Co KGaA, Düsseldorf, Germany; §§Kao Corporation, Safety Science Research Laboratories, Tochigi, Japan; ∥∥Beiersdorf, Hamburg, Germany; and ¶¶LVMH Recherche, St Jean De Braye Cedex, and ##Laboratoire Pierre Fabre, Castres, - - 2014
Although adoption of skin sensitization in vivo assays for hazard identification is likely to be successful in the next few years, this does not replace their use in potency prediction. Notably, measurement of potency of skin sensitizers in the local lymph node assay has been important. However, this local lymph ...
van Brunschot Sharon L SL Plant Biosecurity Cooperative Research Centre, Bruce, Australian Capital Territory, Australia ; School of Agriculture and Food Sciences, The University of Queensland, St Lucia, Queensland, - - 2014
Efficient and reliable diagnostic tools for the routine indexing and certification of clean propagating material are essential for the management of pospiviroid diseases in horticultural crops. This study describes the development of a true multiplexed diagnostic method for the detection and identification of all nine currently recognized pospiviroid species in ...
Vilela E M EM Hospital São João, Porto, - - 2014
A systematic review was carried out to study the pattern of high-sensitivity cardiac troponin release after running (search performed on PubMed, ISI Web of Knowledge and Scopus databases). A total of ten reports were identified as meeting the pre-specified criteria (eight using high-sensitivity troponin T and two using high-sensitivity troponin ...
Roje Dawn M DM Department of Ichthyology, American Museum of Natural History, New York, New York, United States of - - 2014
Nucleotide substitution models used in molecular phylogenetics do not account for nucleotide sequences evolving under selection, yet selection is rarely tested for. If non-neutral markers violate these models (i.e. non-independence of sites), it is expected that their reconstructed topologies be incongruent with those inferred from neutral ones and conclusions made ...
Miyake Yuichi Y a Institute for Environmental Sciences, University of Shizuoka , Shizuoka , - - 2014
Perfluorooctane sulfonate (PFOS) was quantified in seawater and sediment samples collected from Tokyo Bay, Japan, ranging from 2.0 to 7.3 ng/L for surface seawater, 2.2 to 5.7 ng/L for intermediate seawater, 1.5 to 5.7 ng/L for bottom seawater, and 0.3 to 0.9 ng/g dry wt. for sediment. In addition, a 3-D chemical fate prediction ...
Aravindan V - - 2014
Background & objectives: The enzyme glutathione-s-transferases (GSTs) are associated with detoxification of DDT, as experimentally proved in Anopheles gambiae. Insect GSTs are classified into six classes and among them Delta and Epsilon class GSTs have been implicated in detoxification of organochlorine insecticides. Both Delta and Epsilon GSTs produce, in total, ...
Zhu Gaofeng G Faculty of Information Science and Engineering, Ningbo University, Ningbo 315211, - - 2014
To compress stereo video effectively, this paper proposes a novel macroblock (MB) level rate control method based on binocular perception. A binocular just-notification difference (BJND) model based on the parallax matching is first used to describe binocular perception. Then, the proposed rate control method is performed in stereo video coding ...
Leppilahti Jm J Institute of Dentistry, University of Helsinki, Helsinki, - - 2013
To identify the diagnostic accuracy of GCF candidate biomarkers to discriminate periodontitis from the inflamed and healthy sites, and to compare the performance of two independent MMP-8 immunoassays. Cross sectional study. Gingival crevicular fluid (N=58 sites) was collected from healthy, gingivitis and chronic periodontitis volunteers and analyzed for levels of ...
Zhang Hongliang H Zachry Department of Civil Engineering, Texas A&M University, College Station, TX 77843, - - 2013
The performance of the Weather Research and Forecasting (WRF)/Community Multi-scale Air Quality (CMAQ) system in the eastern United States is analyzed based on results from a seven-year modeling study with a 4-km spatial resolution. For 2-m temperature, the monthly averaged mean bias (MB) and gross error (GE) values are generally ...
Hageböck Martin M Research and Teaching Institute for Brewing in Berlin, Seestraße 13, 13353 Berlin, Germany. - - 2013
Newly developed forms of creatine are often claimed to exhibit improved bioavailability and efficacy. They are of great interest for sports nutrition and therapeutic uses. However, for most newer creatine forms stability after ingestion under physiological conditions is insufficiently documented, relevant data are inconsistent or even missing. Therefore, we developed ...
Van Uytfanghe Katleen K Laboratory for Analytical Chemistry, Faculty of Pharmaceutical Sciences, Gent University, Harelbekestraat 72, 9000 Gent, Belgium. Electronic address: - - 2013
According to the measurement paradigm, assays claiming the same measurand should give equivalent results within clinically relevant constraints. The key to accomplish this paradigm is standardization of assays to an SI-traceable reference measurement system. However, measurement results for complex analytes often are not expressed in SI-, but in arbitrary units, ...
Park Jong-Lyul JL Medical Genomics Research Center, KRIBB, Daejeon 305-806, Korea. ; Department of Functional Genomics, University of Science of Technology, Daejeon 305-350, - - 2013
RNA analysis has become a reliable method of body fluid identification for forensic use. Previously, we developed a combination of four multiplex quantitative PCR (qRT-PCR) probes to discriminate four different body fluids (blood, semen, saliva, and vaginal secretion). While those makers successfully identified most body fluid samples, there were some ...
Flegg Jennifer A - - 2013
The emergence of Plasmodium falciparum resistance to artemisinins in Southeast Asia threatens the control of malaria worldwide. The pharmacodynamic hallmark of artemisinin derivatives is rapid parasite clearance (a short parasite half-life), therefore, the in vivo phenotype of slow clearance defines the reduced susceptibility to the drug. Measurement of parasite counts ...
Kuster Nils - - 2013
The National Kidney Disease Education Program group demonstrated that MDRD equation is sensitive to creatinine measurement error, particularly at higher glomerular filtration rates. Thus, MDRD-based eGFR above 60mL/min/1.73m(2) should not be reported numerically. However, little is known about the impact of analytical error on CKD-EPI-based estimates. This study aimed at ...
Eslinger P W - - 2013
Systems designed to monitor airborne radionuclides released from underground nuclear explosions detected radioactive fallout across the northern hemisphere resulting from the Fukushima Dai-ichi Nuclear Power Plant accident in March 2011. Sampling data from multiple International Modeling System locations are combined with atmospheric transport modeling to estimate the magnitude and time ...
Dong Ting - - 2013
In this paper, we consider the combination of markers with and without the limit of detection (LOD). LOD is often encountered when measuring proteomic markers. Because of the limited detecting ability of an equipment or instrument, it is difficult to measure markers at a relatively low level. Suppose that after ...
Paakkunainen Maaret - - 2013
Uncertainty is one of the most critical aspects in determination of measurement reliability. In order to ensure accurate measurements, results need to be traceable and uncertainty measurable. In this study, homogeneity of FTIR samples is determined with a combination of variographic and multivariate approach. An approach for estimation of uncertainty ...
Tran Duong T - - 2013
To estimate bias associated with partial-mouth periodontal examination (PMPE) protocols regarding estimates of prevalence, severity and extent of clinical attachment loss (CAL), pocket depth (PD) and gingival recession (REC). A search was made for articles published in English, from 1946 to 2012, which compared PMPE versus full-mouth periodontal examination protocols ...
Nakamura Munehiro - - 2013
Over-sampling methods based on Synthetic Minority Over-sampling Technique (SMOTE) have beenproposed for classification problems of imbalanced biomedical data. However, the existing oversamplingmethods achieve slightly better or sometimes worse result than the simplest SMOTE. In orderto improve the effectiveness of SMOTE, this paper presents a novel over-sampling method usingcodebooks obtained by ...
Coffey Jacob W - - 2013
Microprojection array (MPA) skin patches selectively capture circulating biomarkers from the dermal layers of the skin, avoiding the need to extract, handle or process blood. Here we investigate the effect of improving biomarker capture in vivo on MPA detection of a model biomarker (antigen-specific-IgG raised in response to Fluvax vaccine) in ...
Xu Huiping - - 2013
In this paper, we consider the design for comparing the performance of two binary classification rules, for example, two record linkage algorithms or two screening tests. Statistical methods are well developed for comparing these accuracy measures when the gold standard is available for every unit in the sample, or in ...
Merešová J - - 2013
The evaluation is presented of a laboratory comparison (LC) on (90)Sr, (40)K and (137)Cs in dried bilberries organised in 2011 by the IRMM. The activity concentrations reported by 88 participant laboratories are compared to the reference values of the new reference material IRMM-426 Wild Berries. Nine per cent and 17% ...
Ramamohan Varun - - 2013
Abstract Background: A statement of measurement uncertainty describes the quality of a clinical assay analysis result, and uncertainty models of clinical assays can be used to evaluate and optimize laboratory protocols designed to minimize the measurement uncertainty associated with an assay. In this study, we propose a methodology to lend ...
Metalnikova Nadia A - - 2013
We present a model of Ca-regulated thin filaments in cardiac muscle where tropomyosin is treated as a continuous elastic chain confined in the closed position on the actin helix by electrostatic forces. The main distinction from previous works is that the intrinsic stress-free helical shape of the tropomyosin chain was ...
Czodrowski Paul - - 2013
A detailed analysis of the hERG content inside the ChEMBL database is performed. The correlation between the outcome from binding assays and functional assays is probed. Based on descriptor distributions, design paradigms with respect to structural and physicochemical properties of hERG active and hERG inactive compounds are challenged. Finally, classification ...
Keir R - - 2013
An extended two compartment model is proposed to describe the dynamics of myoglobin in rhabdomyolysis patients undergoing dialysis. Before using clinical data to estimate the model's unknown parameters, structural identifiability analysis was performed to determine the parameters uniqueness given certain clinical observations. A Taylor series expansion method was implemented which ...
Prochazkova Gita - - 2013
Magnetic harvesting of microalgal biomass provides an attractive alternative to conventional methods. The approach to this issue has so far been pragmatic, focused mainly on finding cheap magnetic agents in combination with harvestable microalgae species. The aim of this work was to study experimentally and theoretically the mechanisms leading to ...
Gianola D - - 2013
The analysis of systems involving many loci is important in population and quantitative genetics. An important problem is the study of linkage disequilibrium (LD), a concept relevant in genome-enabled prediction of quantitative traits and in exploration of marker-phenotype associations. This article introduces a new estimator of a LD parameter (ρ(2)) ...
Fong Youyi - - 2013
Nonlinear calibration is a widely used method for quantifying biomarkers wherein concentration-response curves estimated using samples of known concentrations are used to predict the biomarker concentrations in the samples of interest. The R package nCal fills an important gap in the open source, stand-alone softwares for performing nonlinear calibration. For ...
Maples Brian K BK Department of Genetics, Stanford University, Stanford, CA 94305, USA; Biomedical Informatics Training Program, Stanford University, Stanford, CA 94305, - - 2013
Local-ancestry inference is an important step in the genetic analysis of fully sequenced human genomes. Current methods can only detect continental-level ancestry (i.e., European versus African versus Asian) accurately even when using millions of markers. Here, we present RFMix, a powerful discriminative modeling approach that is faster (~30×) and more ...
Walker Logan C - - 2013
Splicing assays are commonly undertaken in the clinical setting to assess the clinical relevance of sequence variants in disease predisposition genes. A 5-tier classification system incorporating both bioinformatic and splicing assay information was previously proposed as a method to provide consistent clinical classification of such variants. Members of the ENIGMA ...
Gibbs Susan - - 2013
The purpose of this study was to explore the possibility of combining the epidermal equivalent (EE) potency assay with the assay which assesses release of interleukin-18 (IL-18) to provide a single test for identification and classification of skin sensitizing chemicals, including chemicals of low water solubility or stability. A protocol ...
Wang Dan - - 2013
Fecal pollution is measured in surface waters using culture-based measurements of enterococci and Escherichia coli bacteria. Source apportionment of these two fecal indicator bacteria is an urgent need for prioritizing remediation efforts and quantifying health risks associated with source-specific pathogens. There are a number of quantitative real-time PCR (QPCR) assays ...
Armand Stéphane - - 2013
Although, several thorax models have been proposed for clinical gait analysis, none has received widespread acceptance nor been subject to any extensive validation work, especially for the marker set to use. The aim of this study was thus to determine the optimal and minimal makers' placement on the thorax for ...
Ghaedi M - - 2013
In the present study, activated carbon (AC) simply derived from Pistacia khinjuk and characterized using different techniques such as SEM and BET analysis. This new adsorbent was used for methylene blue (MB) adsorption. Fitting the experimental equilibrium data to various isotherm models shows the suitability and applicability of the Langmuir ...
Perkins Neil J - - 2013
Biomarkers are of ever-increasing importance to clinical practice and epidemiologic research. Multiple biomarkers are often measured per patient. Measurement of true biomarker levels is limited by laboratory precision, specifically measuring relatively low, or high, biomarker levels resulting in undetectable levels below, or above, a limit of detection (LOD). Ignoring these ...
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