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Yuki Koichi K Cardiac Anesthesia Division, Department of Anesthesiology, Perioperative and Pain Medicine, Boston Children's Hospital, Boston, MA, USA; Department of Anaesthesia, Harvard Medical School, Boston, MA, - - 2014
Optimizing systemic oxygen delivery (DO2 ) and hemodynamics in children with hypoplastic left heart syndrome (HLHS) is a clinical challenge. Mathematical modeling of the HLHS circulation has been used to determine the relationship between oxygen kinetic parameters and DO2 and to determine how DO2 might be optimized. The model demonstrates ...
Carboni Ilaria I Azienda Ospedaliero-Universitaria "Careggi", Diagnostic Genetics Unit, Largo Brambilla, 3, I-50134, Florence, - - 2014
In a standard paternity testing, mother, child, and alleged father are analyzed with STR markers using commercially available kits. Since Italian civil legislation does not have thresholds to confirm a paternity, paternity is practically proven when likelihood ratio increases prior probability of paternity to posterior, accepted by court as sufficient. ...
Lungu A A University of Sheffield, Cardiovascular Science Department, Sheffield, South Yorkshire, UK. Electronic address: - - 2014
Pulmonary hypertension(PH) is a disorder characterised by increased mean pulmonary arterial pressure. Currently, the diagnosis of PH relies upon measurements taken during invasive right heart catheterisation (RHC). This paper describes a process to derive diagnostic parameters using only non-invasive methods based upon MRI imaging alone. Simultaneous measurements of main pulmonary ...
Gualdrón Duarte Jose L - - 2014
Currently, association studies are analysed using statistical mixed models, with marker effects estimated by a linear transformation of genomic breeding values. The variances of marker effects are needed when performing the tests of association. However, approaches used to estimate the parameters rely on a prior variance or on a constant ...
Tan Chin Hon CH Department of Industrial and Systems Engineering, National University of Singapore, Singapore, - - 2014
When a systematic error is detected in the analytical process, ideally, one seeks to retest only patient samples between the onset of the error and the time the error was detected. In practice, the onset of error is often unknown, and patient samples are retrospectively retested back to the last ...
Ghaedi M M Chemistry Department, Yasouj University, Yasouj 75918-74831, Iran. Electronic address: - - 2014
Activated carbon was prepared from walnut wood which was locally available, non-toxic, abundant and cheap. This new adsorbent was characterized using BET, FTIR and SEM. Point of zero charge (pHpzc) and oxygen containing functional groups were also determined. The prepared adsorbent was applied for simultaneous removal of Pb(2+) ions and ...
Vázquez Julián J CIQSO - Center for Research in Sustainable Chemistry and Department of Chemical Engineering, Physical Chemistry, and Organic Chemistry, University of Huelva, Campus de El Carmen s/n, 21071 Huelva (Spain), Fax: (+34) 959 21 99 - - 2014
A new approach towards the rapid identification of quality binders to cucurbiturils-those that combine high affinity with high selectivity for a particular homologue-was developed. The assay exploits macrocycle-specific optical fingerprints (colorimetric or fluorimetric) of carefully selected indicators dyes. The screening of a guest library revealed known (e.g., adamantane derivatives) and ...
McCrae Robert R RR Baltimore, Maryland, USA - - 2014
Retest reliability is a better predictor of validity than is internal consistency. One explanation for this is item-specific variance, which distinguishes different nuances of a facet and contributes to retest reliability but not internal consistency. Specific variance at the facet level is temporally stable, consensually validated, and heritable; a consideration ...
Martínez-Camblor Pablo P Oficina de Investigación Biosanitaria de Asturias (OIB-FICYT) Universidad Autonoma de Chile, Chile - - 2014
The receiver operating characteristic curve is a popular graphical method frequently used in order to study the diagnostic capacity of continuous markers. It represents in a plot true-positive rates against the false-positive ones. Both the practical and theoretical aspects of the receiver operating characteristic curve have been extensively studied. Conventionally, ...
Grintzalis Konstantinos K Genetics, Cell and Developmental Biology Section, Department of Biology, University of Patras, Patras, Greece. Electronic address: - - 2014
Thiol redox state (TRS) evaluation is mostly restricted to the estimation of GSH and GSSG. However, these TRS parameters can estimate the GSSG/GSH potential, which might be useful to indicate abnormalities in redox metabolism. Nonetheless, evaluation of the multiparameric nature of TRS is required for a more accurate assessment of ...
Feng Dai D a Biometrics Research, Merck Research - - 2014
Abstract Need for assessment of agreement arises in many situations including statistical biomarker qualification or assay or method validation. Concordance correlation coefficient (CCC) is one of the most popular scaled indices reported in evaluation of agreement. Robust methods for CCC estimation currently present an important statistical challenge. Here, we propose ...
Reising Monica M MM Center for Veterinary Biologics, Policy Evaluation and Licensing, Statistics Section, Ames, IA (Reising, Siev)National Veterinary Services Laboratories, Foreign Animal Disease Diagnostic Laboratory, Plum Island, NY (Schumann, Glas)California Animal Health and Food Safety Laboratory, Department of Medicine and Epidemiology, University of California, Davis, CA (Crossley)Animal Health Diagnostic Center, Cornell University, Ithaca, NY (Jacobson)Wisconsin Veterinary Diagnostic Laboratory and Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI (Toohey-Kurth)National Veterinary Services Laboratories, Diagnostic Virology Laboratory, Ames, IA (Pedersen)Paul G. Allen School for Global Animal Health, Washington State University, Pullman, WA (Martin) - - 2014
The current report discusses the process in which a methods comparison study in the National Animal Health Laboratory Network is performed. Specific details are provided for designing and analyzing studies intended to evaluate analytical sensitivity, efficiency, analytical specificity, cross-contamination, repeatability, operator variability, and to compare the performance of methods using ...
Zhong Jianpeng J School of Electrical Engineering, Xi׳an Jiaotong University, 28 Xianning West Road, Xi׳an 710049, China. Electronic address: - - 2014
This paper presents the application of fractional-order system identification (FOSI) and proportional-derivative (PD(µ)) control to a solid-core magnetic bearing (MB). A practical strategy for closed-loop incommensurate FOSI along with a modified error criterion is utilized to model the MB system and a corresponding, verification experiment is carried out. Based on ...
Kinders Robert R Authors' Affiliations: Laboratory of Human Toxicology and Pharmacology; National Cancer Target Validation Laboratory, Applied/Developmental Research Directorate, Frederick National Laboratory for Cancer Research and Leidos Biomedical Research, Inc., Frederick, Maryland - - 2014
There is a "life cycle" of pharmacodynamic (PD) biomarker assays that guides the development and clinical implementation in our laboratories. The well-recognized elements of analytical assay validation and demonstration of fitness-for-purpose of the biomarker, specimen collection, handling, and assay methods are only a part of the required activities. Assay transfer ...
Grubb Anders A Department of Clinical Chemistry, Laboratory Medicine, University Hospital, Lund, Sweden; - - 2014
Many different cystatin C-based equations exist for estimating glomerular filtration rate. Major reasons for this are the previous lack of an international cystatin C calibrator and the nonequivalence of results from different cystatin C assays. Use of the recently introduced certified reference material, ERM-DA471/IFCC, and further work to achieve high ...
Chen Jian-Bo JB Department of Chemistry, Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Tsinghua University, Beijing, 100084, - - 2014
Finished herbal products (FHPs) are preparations made from one or more herbs. The first stage in assuring the quality, safety, and efficacy of FHPs is to identify the herbs in the products. A new simple and quick method is developed in this research to detect the marker ingredients in FHPs. ...
Bonnechère B B a Laboratory of Anatomy, Biomechanics and Organogenesis (LABO) , Université Libre de Bruxelles , Brussels , - - 2014
The recent availability of the Kinect™ sensor, a low-cost Markerless Motion Capture (MMC) system, could give new and interesting insights into ergonomics (e.g. the creation of a morphological database). Extensive validation of this system is still missing. The aim of the study was to determine if the Kinect™ sensor can ...
Eng Kevin H KH Roswell Park Cancer Institute, Department of Biostatistics and Bioinformatics, Elm and Carlton Streets, Buffalo, NY, 14263, - - 2014
We describe a novel study design for validating marker-based treatment strategies meant to select among possible therapeutic options using a biologic marker. Studying existing designs in realistic scenarios, we demonstrate that this design is more than four times more efficient for testing the interaction between a marker and its intended ...
Hens Koen - - 2014
Abstract Background: Six Sigma metrics were used to assess the analytical quality of automated clinical chemistry and immunoassay tests in a large Belgian clinical laboratory and to explore the importance of the source used for estimation of the allowable total error. Clinical laboratories are continually challenged to maintain analytical quality. ...
Lippi Giuseppe G Laboratory of Clinical Chemistry and Hematology, Academic Hospital of Parma , Parma , - - 2014
The laboratory assessment of cardiospecific troponins(s) represents the cornerstone for the diagnosis of acute coronary syndrome (ACS). Although troponin immunoassays are classified according to either analytical imprecision or percentage of measurable values in a presumably healthy population, it is rather clear that the nomenclature of commercial methods according to these ...
Aubry Anne-Françoise AF Analytical & Bioanalytical Development, Bristol-Myers Squibb, Princeton, NJ 08540, - - 2014
The last 10 years have witnessed robust debate within the bioanalytical community and regulatory authorities on the topic of metabolite monitoring and safety assessment. Of particular interest to regulated bioanalytical laboratories was the acceptance by the US FDA and other major regulatory bodies of a tiered approach to bioanalytical assay ...
Tsoi Jennifer J Department of Molecular & Medical Pharmacology, Crump Institute for Molecular Imaging, University of California, Los Angeles, CA 90095, USA. - - 2014
Background: Design of experiments (DOE) is utilized in optimizing ligand-binding assay by modeling factor effects. To reduce the analyst's workload and error inherent with DOE, we propose the integration of automated liquid handlers to perform the randomized designs. Results: A randomized design created from statistical software was imported into custom ...
Brulé Mathieu M State Institute of Agricultural Engineering and Bioenergy, University of Hohenheim, Stuttgart, Germany, - - 2014
Biochemical methane potential assays, usually run in batch mode, are performed by numerous laboratories to characterize the anaerobic degradability of biogas substrates such as energy crops, agricultural residues, and organic wastes. Unfortunately, the data obtained from these assays lacks common, universal bases for comparison, because standard protocols did not diffuse ...
Karajan N N Institute of Applied Mechanics (Civil Engineering), University of Stuttgart, Pfaffenwaldring 7, Stuttgart, 70569, Germany, - - 2014
A possibility to simulate the mechanical behaviour of the human spine is given by modelling the stiffer structures, i.e. the vertebrae, as a discrete multi-body system (MBS), whereas the softer connecting tissue, i.e. the softer intervertebral discs (IVD), is represented in a continuum-mechanical sense using the finite-element method (FEM). From ...
Teunis Marc A T MA University of Applied Sciences, Utrecht, The - - 2014
This study describes the international ring trial of the epidermal-equivalent (EE) sensitizer potency assay. This assay does not distinguish a sensitizer from a non-sensitizer, but may classify known skin sensitizers according to their potency. It assesses the chemical concentration resulting in 50% cytotoxicity (EE-EC50) or the 2-fold increase in IL-1α ...
Osis Sean T ST a Faculty of Kinesiology, University of Calgary , Calgary , - - 2014
As biomechanical research evolves, a continuing challenge is the standardization of data collection and analysis techniques. In gait analysis, placement of markers to construct an anatomical model has been identified as the single greatest source of error; however, there is currently no standardized approach to quantifying these errors. The current ...
Wang J J Institute of Zoology, Zoological Society of London, London, - - 2014
Inbreeding (F) of and relatedness (r) between individuals are now routinely calculated from marker data in studies in the fields of quantitative genetics, conservation genetics, forensics, evolution and ecology. Although definable in terms of either correlation coefficient or probability of identity by descent (IBD) relative to a reference, they are ...
Brainard Benjamin M BM Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, University of Georgia, Athens, GA - - 2014
To systematically examine the evidence on nontraditional uses of viscoelastic coagulation monitoring in veterinary species. Standardized, systematic evaluation of the literature, categorization of relevant articles according to level of evidence and quality, and development of consensus on conclusions for application of the concepts to clinical practice. Academic and referral veterinary ...
Hsu Man-Jen - - 2014
A biomarker is usually used as a diagnostic or assessment tool in medical research. Finding an ideal biomarker is not easy and combining multiple biomarkers provides a promising alternative. Moreover, some biomarkers based on the optimal linear combination do not have enough discriminatory power. As a result, the aim of ...
García-Cortés L A LA Departamento de Mejora Genética Animal, INIA, Madrid, - - 2014
The genetic relationship among individuals at one locus is characterized by nine coefficients of identity. The coefficients of inbreeding, coancestry and dominance (or fraternity) are just linear functions of them. Here, it is shown how they can be estimated using biallelic and triallelic markers using the method of moments, and ...
Basketter David A DA From the *DABMEB Consultancy Ltd, Sharnbrook, Bedford, UK; †L'Oréal Research & Innovation, Aulnay Sous Bois, France; ‡Shiseido Co, Ltd, Quality Assurance Center, Kanagawa, Japan; §Cosmetics Europe, The Personal Care Association, Brussels, Belgium; ∥Unilever, Safety and Environmental Assurance Centre, Bedford, Sharnbrook, United Kingdom; ¶The Procter & Gamble Company, Darmstadt, Germany; #Chanel, Neuilly sur Seine, France; **Seh Consulting + Services, Paderborn, Germany; ††The Procter & Gamble Company, Strombeek Bever, Belgium; ‡‡Henkel AG & Co KGaA, Düsseldorf, Germany; §§Kao Corporation, Safety Science Research Laboratories, Tochigi, Japan; ∥∥Beiersdorf, Hamburg, Germany; and ¶¶LVMH Recherche, St Jean De Braye Cedex, and ##Laboratoire Pierre Fabre, Castres, - - 2014
Although adoption of skin sensitization in vivo assays for hazard identification is likely to be successful in the next few years, this does not replace their use in potency prediction. Notably, measurement of potency of skin sensitizers in the local lymph node assay has been important. However, this local lymph ...
van Brunschot Sharon L SL Plant Biosecurity Cooperative Research Centre, Bruce, Australian Capital Territory, Australia ; School of Agriculture and Food Sciences, The University of Queensland, St Lucia, Queensland, - - 2014
Efficient and reliable diagnostic tools for the routine indexing and certification of clean propagating material are essential for the management of pospiviroid diseases in horticultural crops. This study describes the development of a true multiplexed diagnostic method for the detection and identification of all nine currently recognized pospiviroid species in ...
Vilela E M EM Hospital São João, Porto, - - 2014
A systematic review was carried out to study the pattern of high-sensitivity cardiac troponin release after running (search performed on PubMed, ISI Web of Knowledge and Scopus databases). A total of ten reports were identified as meeting the pre-specified criteria (eight using high-sensitivity troponin T and two using high-sensitivity troponin ...
Roje Dawn M DM Department of Ichthyology, American Museum of Natural History, New York, New York, United States of - - 2014
Nucleotide substitution models used in molecular phylogenetics do not account for nucleotide sequences evolving under selection, yet selection is rarely tested for. If non-neutral markers violate these models (i.e. non-independence of sites), it is expected that their reconstructed topologies be incongruent with those inferred from neutral ones and conclusions made ...
Miyake Yuichi Y a Institute for Environmental Sciences, University of Shizuoka , Shizuoka , - - 2014
Perfluorooctane sulfonate (PFOS) was quantified in seawater and sediment samples collected from Tokyo Bay, Japan, ranging from 2.0 to 7.3 ng/L for surface seawater, 2.2 to 5.7 ng/L for intermediate seawater, 1.5 to 5.7 ng/L for bottom seawater, and 0.3 to 0.9 ng/g dry wt. for sediment. In addition, a 3-D chemical fate prediction ...
Aravindan V - - 2014
Background & objectives: The enzyme glutathione-s-transferases (GSTs) are associated with detoxification of DDT, as experimentally proved in Anopheles gambiae. Insect GSTs are classified into six classes and among them Delta and Epsilon class GSTs have been implicated in detoxification of organochlorine insecticides. Both Delta and Epsilon GSTs produce, in total, ...
Zhu Gaofeng G Faculty of Information Science and Engineering, Ningbo University, Ningbo 315211, - - 2014
To compress stereo video effectively, this paper proposes a novel macroblock (MB) level rate control method based on binocular perception. A binocular just-notification difference (BJND) model based on the parallax matching is first used to describe binocular perception. Then, the proposed rate control method is performed in stereo video coding ...
Badano Davide D Istituto per lo Studio degli Ecosistemi, Consiglio Nazionale delle Ricerche (ISE-CNR), Traversa la Crucca 3, Regione Baldinca, I-07100 Li Punti SS, Italy & Sezione di Entomologia e Patologia Vegetale, Dipartimento di Agraria, Università degli Studi, via Enrico De Nicola, I-07100 Sassari SS, Italy.; Email: - - 2014
The third instar larvae of Gepus invisus and Solter liber are comparatively described and illustrated for the first time with a particular emphasis on genus level characters. Larval morphology confirms a close relationship between these genera as they differ only in minor characters.
Vattikuti Shashaank S Mathematical Biology Section, Laboratory of Biological Modeling, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, South Drive, Bethesda, MD 20814, - - 2014
The aim of a genome-wide association study (GWAS) is to isolate DNA markers for variants affecting phenotypes of interest. This is constrained by the fact that the number of markers often far exceeds the number of samples. Compressed sensing (CS) is a body of theory regarding signal recovery when the ...
Leppilahti Jm J Institute of Dentistry, University of Helsinki, Helsinki, - - 2013
To identify the diagnostic accuracy of GCF candidate biomarkers to discriminate periodontitis from the inflamed and healthy sites, and to compare the performance of two independent MMP-8 immunoassays. Cross sectional study. Gingival crevicular fluid (N=58 sites) was collected from healthy, gingivitis and chronic periodontitis volunteers and analyzed for levels of ...
Zhang Hongliang H Zachry Department of Civil Engineering, Texas A&M University, College Station, TX 77843, - - 2013
The performance of the Weather Research and Forecasting (WRF)/Community Multi-scale Air Quality (CMAQ) system in the eastern United States is analyzed based on results from a seven-year modeling study with a 4-km spatial resolution. For 2-m temperature, the monthly averaged mean bias (MB) and gross error (GE) values are generally ...
Hageböck Martin M Research and Teaching Institute for Brewing in Berlin, Seestraße 13, 13353 Berlin, Germany. - - 2013
Newly developed forms of creatine are often claimed to exhibit improved bioavailability and efficacy. They are of great interest for sports nutrition and therapeutic uses. However, for most newer creatine forms stability after ingestion under physiological conditions is insufficiently documented, relevant data are inconsistent or even missing. Therefore, we developed ...
Van Uytfanghe Katleen K Laboratory for Analytical Chemistry, Faculty of Pharmaceutical Sciences, Gent University, Harelbekestraat 72, 9000 Gent, Belgium. Electronic address: - - 2013
According to the measurement paradigm, assays claiming the same measurand should give equivalent results within clinically relevant constraints. The key to accomplish this paradigm is standardization of assays to an SI-traceable reference measurement system. However, measurement results for complex analytes often are not expressed in SI-, but in arbitrary units, ...
Park Jong-Lyul JL Medical Genomics Research Center, KRIBB, Daejeon 305-806, Korea. ; Department of Functional Genomics, University of Science of Technology, Daejeon 305-350, - - 2013
RNA analysis has become a reliable method of body fluid identification for forensic use. Previously, we developed a combination of four multiplex quantitative PCR (qRT-PCR) probes to discriminate four different body fluids (blood, semen, saliva, and vaginal secretion). While those makers successfully identified most body fluid samples, there were some ...
Flegg Jennifer A - - 2013
The emergence of Plasmodium falciparum resistance to artemisinins in Southeast Asia threatens the control of malaria worldwide. The pharmacodynamic hallmark of artemisinin derivatives is rapid parasite clearance (a short parasite half-life), therefore, the in vivo phenotype of slow clearance defines the reduced susceptibility to the drug. Measurement of parasite counts ...
Kuster Nils - - 2013
The National Kidney Disease Education Program group demonstrated that MDRD equation is sensitive to creatinine measurement error, particularly at higher glomerular filtration rates. Thus, MDRD-based eGFR above 60mL/min/1.73m(2) should not be reported numerically. However, little is known about the impact of analytical error on CKD-EPI-based estimates. This study aimed at ...
Eslinger P W - - 2013
Systems designed to monitor airborne radionuclides released from underground nuclear explosions detected radioactive fallout across the northern hemisphere resulting from the Fukushima Dai-ichi Nuclear Power Plant accident in March 2011. Sampling data from multiple International Modeling System locations are combined with atmospheric transport modeling to estimate the magnitude and time ...
Dong Ting - - 2013
In this paper, we consider the combination of markers with and without the limit of detection (LOD). LOD is often encountered when measuring proteomic markers. Because of the limited detecting ability of an equipment or instrument, it is difficult to measure markers at a relatively low level. Suppose that after ...
Paakkunainen Maaret - - 2013
Uncertainty is one of the most critical aspects in determination of measurement reliability. In order to ensure accurate measurements, results need to be traceable and uncertainty measurable. In this study, homogeneity of FTIR samples is determined with a combination of variographic and multivariate approach. An approach for estimation of uncertainty ...
Tran Duong T - - 2013
To estimate bias associated with partial-mouth periodontal examination (PMPE) protocols regarding estimates of prevalence, severity and extent of clinical attachment loss (CAL), pocket depth (PD) and gingival recession (REC). A search was made for articles published in English, from 1946 to 2012, which compared PMPE versus full-mouth periodontal examination protocols ...
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