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Saadati Maral M Division of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg, D69120,   2014
With the fast growing field of epigenetics comes the need to better understand the intricacies of DNA methylation data analysis. Highthroughput profiling using techniques, such as Illumina's BeadArray assay, enable the quantitative assessment of methylation. Challenges arise from the fact that resulting methylation levels (socalled beta values) are proportions between ...


Wang Xinhui   2014
Nonspecific feature selection is a dimension reduction procedure performed prior to cluster analysis of high dimensional molecular data. Not all measured features are expected to show biological variation, so only the most varying are selected for analysis. In DNA methylation studies, DNA methylation is measured as a proportion, bounded between ...


Hayami Masao M Department of Chemistry and Biochemistry, School of Advanced Science and Engineering, Waseda University, Tokyo, 1698555,   2014
An algorithm of the accompanying coordinate expansion and recurrence relation (ACERR), which is used for the rapid evaluation of the electron repulsion integral (ERI), has been extended to the generalcontraction (GC) scheme. The present algorithm, denoted by GCACERR, is designed for molecular calculations including heavy elements, whose orbitals consist of ...


DeGrandiHoffman Gloria G Carl Hayden Bee Research Center, USDAARS, 2000 East Allen Road, Tucson, AZ, 85719, USA,   2014
Varroa (Varroa destuctor Anderson and Trueman) populations in honey bee (Apis mellifera L.) colonies might be kept at low levels by welltimed miticide applications. HopGuard(®) (HG) that contains beta plant acids as the active ingredient was used to reduce mite populations. Schedules for applications of the miticide that could maintain ...


Ghaedi M M Department of Chemistry, Yasouj University, Yasouj 7591874831, Iran. Electronic address:   2014
The influence of variables, namely initial dye concentration, adsorbent dosage (g), stirrer speed (rpm) and contact time (min) on the removal of methyl orange (MO) by gold nanoparticles loaded on activated carbon (AuNPAC) and Tamarisk were investigated using multiple linear regression (MLR) and artificial neural network (ANN) and the variables ...


Stier Adrian C   2014
Trophic island biogeography theory predicts that the effects of predators on prey diversity are context dependent in heterogeneous landscapes. Specifically, models predict that the positive effect of habitat area on prey diversity should decline in the presence of predators, and that predators should modify the partitioning of alpha and beta ...


Galvis Diana M DM Departamento de Estatística, IMECCUNICAMP, Campinas, São Paulo,   2014
Continuous (clustered) proportion data often arise in various domains of medicine and public health where the response variable of interest is a proportion (or percentage) quantifying disease status for the cluster units, ranging between zero and one. However, because of the presence of relatively diseasefree as well as heavily diseased ...


Messner Michael J MJ Office of Water, U.S. Environmental Protection Agency, Washington, DC,   2014
This study utilizes old and new Norovirus (NoV) human challenge data to model the doseresponse relationship for human NoV infection. The combined data set is used to update estimates from a previously published betaPoisson doseresponse model that includes parameters for virus aggregation and for a betadistribution that describes variable susceptibility ...


Panero L M LM Università degli Studi dell'Insubria, 22100 Como,   2014
The internal alpha dose assessment (ICRP 65, 1994) depends on the value of the equilibrium factor F. This parameter is generally not measured and a mean conventional value ranging between 0.4 and 0.6 is assumed, possibly leading to a significant bias in the dose assessments. In this paper, a method ...


HernándezCeballos M A MA Department of Applied Physics, University of Huelva, Huelva, Spain,   2014
Airborne pollen transport at micro, mesogamma and mesobeta scales must be studied by atmospheric models, having special relevance in complex terrain. In these cases, the accuracy of these models is mainly determined by the spatial resolution of the underlying meteorological dataset. This work examines how meteorological datasets determine the results ...


Amato Ernesto E Section of Radiological Sciences, Department Biomedical Sciences and of Morphologic and Functional Imaging, University of Messina, Messina,   2014
To assess the radiation burden of nonhuman living organisms, dose coefficients are available in the literature, precalculated by assuming an ellipsoidal shape of each organism. A previously developed analytical method was applied for the determination of absorbed fractions inside ellipsoidal volumes from alpha, beta, and gamma radiations to the calculation ...


Wang XiaoFeng XF Department of Quantitative Health Sciences/Biostatistics Section, Cleveland Clinic Lerner Research Institute, Cleveland, OH, 44195,   2014
Diffusion tensor imaging (DTI) is a quantitative magnetic resonance imaging technique that measures the threedimensional diffusion of water molecules within tissue through the application of multiple diffusion gradients. This technique is rapidly increasing in popularity for studying white matter properties and structural connectivity in the living human brain. One of ...


Cao Teng   2014
The fatigue that users suffer when using steadystate visual evoked potential (SSVEP)based braincomputer interfaces (BCIs) can cause a number of serious problems such as signal quality degradation and system performance deterioration, users' discomfort and even risk of photosensitive epileptic seizures, posing heavy restrictions on the applications of SSVEPbased BCIs. Towards ...


Yang Jinzhong J Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas. Electronic address:   2014
To develop a new approach for interobserver variability analysis. Eight radiation oncologists specializing in breast cancer radiation therapy delineated a patient's left breast "from scratch" and from a template that was generated using deformable image registration. Three of the radiation oncologists had previously received training in Radiation Therapy Oncology Group ...


Höcht Christian C Universidad de Buenos Aires, School of Pharmacy and Biochemistry, Facultad de Farmacia y Bioquímica, Department of Pharmacology , Junín 956, (C1113AAD) Buenos Aires , Argentina +54 11 4964 8265 ; +54 11 4508 3645 ;   2014
Introduction: βblocker therapy plays an important role in the treatment of various diseases, including hypertension, myocardial infarction and heart failure. Although all βblockers shared their ability to competitively block β1adrenoceptor, this therapeutic class showed great heterogeneity in their pharmacokinetic (PK) and pharmacodynamic (PD) properties. Areas covered: The present review describes ...


Sun Deqiang   2014
Bisulfite sequencing (BSseq) is the gold standard for studying genomewide DNA methylation. We developed MOABS to increase the speed, accuracy, statistical power and biological relevance of BSseq data analysis. MOABS detects differential methylation with 10fold coverage at singleCpG resolution based on a BetaBinomial hierarchical model and is capable of processing ...


Mroczek Dariusz D 1Chair of Motor Activity, University School of Physical Education, Wroclaw, Poland 2Faculty of Physical Education and Physiotherapy, Opole University of Technology,   2014
The present study aims to assess motor activity of volleyball players using an original video recording method developed by the authors. 28 volleyball players taking part in four matches of the Polish Volleyball League were examined. The recorded data were analyzed in view of the mean total distance covered by ...


Demetrashvili Nino N 1Department of Epidemiology, University Medical Center Groningen, University of Groningen, RB Groningen, the   2014
Confidence intervals for intraclass correlation coefficients in agreement studies with continuous outcomes are modelspecific and no generic approach exists. This paper provides two generic approaches for intraclass correlation coefficients of the form $$\sum _{q=1}^{Q}{\sigma }_{q}^{2}/(\sum _{q=1}^{Q}{\sigma }_{q}^{2}+\sum _{p=Q+1}^{P}{\sigma }_{p}^{2})$$. The first approach uses Satterthwaite's approximation and an Fdistribution. The second ...


Kim JaeKwan JK Vorononi Diagram Research Center, Hanyang University,   2014
Molecular external structure is important for molecular function, with voids on the surface and interior being one of the most important features. Hence, recognition of molecular voids and accurate computation of their geometrical properties, such as volume, area and topology, are crucial, yet most popular algorithms are based on the ...


Meaney Christopher   2014
In biomedical research, response variables are often encountered which have bounded support on the open unit interval  (0,1). Traditionally, researchers have attempted to estimate covariate effects on these types of response data using linear regression. Alternative modelling strategies may include: beta regression, variabledispersion beta regression, and fractional logit regression ...


Choi Yongju   2014
The validity of a hydrophobic organic contaminant mass transfer model to predict the effectiveness of insitu AC treatment under stagnant sedimentAC contact is studied for different contaminants and sediments. The modeling results and data from a previous 24month column study experiment of uptake in polyethylene samplers are within a factor ...


Wang Xiaoyan   2014
Among the methods of parallel magnetic resonance imaging (PMRI), Generalized Autocalibrating Partially Parallel Acquisitions (GRAPPA) technique reconstructs the missing kspace data by a set of weights, which are derived from autocalibration signal (ACS) lines acquired in parallel to the reduced lines. In this paper, a novel hybrid method is proposed ...


Martin Andrew A NHS Greater Manchester Commissioning Support Unit, Salford, Manchester,   2014
Background: Generic losartan provides an opportunity to enhance angiotensin receptor blocker (ARB) prescribing efficiency, with all ARBs essentially being similar. Initially, there was limited activity in NHS Bury (UK). This changed in March 2011 with therapeutic switching and other measures encouraging the prescribing of losartan following generics to enhance its ...


Legendre Pierre P Département de Sciences Biologiques, Université de Montréal, , C.P. 6128, Succursale Centreville, Montréal, Québec, Canada , H3C 3J7, Laboratoire des Sciences de l'Environnement Marin (LEMAR), UMR CNRS 6539, Institut Universitaire Européen de la Mer, Université de Bretagne Occidentale, , rue Dumont d'Urville, Plouzané 29280,   2014
This review focuses on the analysis of temporal beta diversity, which is the variation in community composition along time in a study area. Temporal beta diversity is measured by the variance of the multivariate community composition time series and that variance can be partitioned using appropriate statistical methods. Some of ...


Otani Koichi   2014
It has been suggested that interpersonal sensitivity, a personality trait associated with depression and anxiety disorders, is linked with attachment insecurity. To confirm this link, we studied the correlations of interpersonal sensitivity with working models of the self and other. The subjects were 301 healthy Japanese. Interpersonal sensitivity and working ...


MonteroMarin Jesus J Faculty of Health Sciences and Sports, University of Zaragoza, Huesca, Spain ; Department of Psychiatry, University of Zaragoza, Zaragoza, Spain ; REDIAPP "Red de Investigación en Actividades Preventivas y Promoción de la Salud" (Research Network on Preventative Activities and Health Promotion), Zaragoza,   2014
Burnout occurs when professionals use ineffective coping strategies to try to protect themselves from workrelated stress. The dimensions of 'overload', 'lack of development' and 'neglect', belonging to the 'frenetic', 'underchallenged' and 'wornout' subtypes, respectively, comprise a brief typological definition of burnout. The aim of the present study was to estimate ...


Marcon Eric E AgroParisTech, UMR Écologie des Forêts de Guyane, Kourou Cedex,   2014
Traditional measures of diversity, namely the number of species as well as Simpson's and Shannon's indices, are particular cases of Tsallis entropy. Entropy decomposition, i.e. decomposing gamma entropy into alpha and beta components, has been previously derived in the literature. We propose a generalization of the additive decomposition of Shannon ...


Wang Ling L Research Center for Drug Discovery & Institute of Human Virology, School of Pharmaceutical Sciences, Sun Yatsen University, Guangzhou,   2014
Mammalian target of rapamycin (mTOR) is a central controller of cell growth, proliferation, metabolism, and angiogenesis. Thus, there is a great deal of interest in developing clinical drugs based on mTOR. In this paper, in silico models based on multiscaffolds were developed to predict mTOR inhibitors or noninhibitors. First 1,264 ...


Raineri Emanuele E Statistical Genomics, Centro Nacional de Análisis Genómico, Barcelona, Catalonia,   2014
We apply a known algorithm for computing exactly inequalities between Beta distributions to assess whether a given position in a genome is differentially methylated across samples. We discuss the advantages brought by the adoption of this solution with respect to two approximations (Fisher's test and Z score). The same formalism ...


Tseng KuoKun KK 0000000262587009 Harbin Institute of Technology, Shenzhen Graduate School, Shenzhen,   2014
In recent years, many approaches have been suggested for Internet and web streaming detection. In this paper, we propose an approach to signal waveform detection for Internet and web streaming, with novel statistical automatons. The system records network connections over a period of time to form a signal waveform and ...


Kanoatov Mirzo   2013
We describe a mathematical approach that enables extraction of kinetic rate constants from thousands of studies conducted over the past two decades with affinity capillary electrophoresis (ACE). Previously, ACE has been used almost exclusively for obtaining equilibrium constants of intermolecular interactions. In this article, we prove that there exists an ...


Noel Yvonnick   2013
An unfolding model for continuous bounded responses is proposed, derived both from a hypothetical interpolation response mechanism and from the hypothesis of two opposite sources of item refusal being collapsed. These two sources of refusal are made explicit in a threecomponent Dirichlet response model and then collapsed to obtain a (twocomponent) beta response ...


Stanga D D National Institute of R&D for Physics and Nuclear Engineering "HoriaHulubei", IFINHH, P.O.Box MG6, BucharestMagurele R077125, Romania. Electronic address:   2013
A simple method has been developed for determining the activity of largearea beta reference sources in anodized aluminum foils. It is based on the modeling of the transmission of beta rays through thin foils in planar geometry using Monte Carlo simulation. The method was checked experimentally and measurement results show ...


Iknayan Kelly J   2013
Estimates of species richness and diversity are central to community and macroecology and are frequently used in conservation planning. Commonly used diversity metrics account for undetected species primarily by controlling for sampling effort. Yet the probability of detecting an individual can vary among species, observers, survey methods, and sites. We ...


Havelka Miroslav M Czech Metrology Institute, Inspectorate for Ionizing Radiation, Radiová 1, 102 00 Prague, Czech Republic. Electronic address:   2013
The activity of the radionuclide (64)Cu was determined by the efficiency extrapolation method applied to 4π(PC)γ coincidence counting. The standardisation was performed by software coincidence countinga digital method for primary activity measurement that simplifies the setting of optimal coincidence parameters. The γrayenergy window, characterised by identical gamma detection efficiency related ...


Lee ChangHyun   2013
The sylvian arachnoid cyst (AC) is a common benign disease; however, it sometimes leads to subdural or intracystic hemorrhage without major trauma. The reason of easy bleeding of the AC is not fully understood. The purpose of this study was to investigate the bleeding mechanism of the sylvian AC in ...


Hardy J C   2013
Because of angularmomentum conservation, superallowed β decay between 0(+) analog states involves only the vector part of the weak interaction, so its measured ft value can be used to determine the vector coupling constant, GV. If many such transitions are measured, then the constancy of GV can be established and ...


Battisti Sabrina   2013
In May 2005, betahexachlorocyclohexane (βHCH) was found in a sample of bovine bulk milk from a farm in the Sacco River valley (Latium region, central Italy). The primary source of contamination was suspected to be industrial discharge into the environment with the Sacco River as the main mean of dispersion. ...


Kalantari Mojgan M Department of Radiology, Mahdiyeh Hospital, Shahid Beheshti University of Medical Sciences, Tehran,   2013
Background: Abdominal circumference (AC), biparietal diameters (BPD) and femoral length (FL) are now the main parameters used to obtain estimated fetal weight (EFW). Although the role of soft tissue parameters in determining fetal weight was proved but clinical attention to midthigh soft tissue thickness (STT) is limited. Objective: To find ...


Wentao Fan   2013
A large class of problems can be formulated in terms of the clustering process. Mixture models are an increasingly important tool in statistical pattern recognition and for analyzing and clustering complex data. Two challenging aspects that should be addressed when considering mixture models are how to choose between a set ...


Zhou Mingyuan   2013
The seemingly disjoint problems of count and mixture modeling are united under the negative binomial (NB) process. A gamma process is employed to model the rate measure of a Poisson process, whose normalization provides a random probability measure for mixture modeling and whose marginalization leads to a NB process for ...


He Wenqi   2013
We comment on the recent Letter, by Liu et al. [Opt. Lett.38, 1651 (2013)] in which a method to improve the security strength of the asymmetric cryptosystem (ACS) by Qin and Peng [Opt. Lett.35, 118 (2010)] was proposed. However, in accordance with Liu's methodology, we could easily find other more efficient ...


Yu Xiaoyi   2013
Longterm storage of articular cartilage (AC) has excited great interest due to the practical surgical significance of this tissue. The liquidustracking (LT) method developed by Pegg et al. [Cryobiology, 52 (2006) 360368] for vitreous preservation of AC achieved reasonable survival of postwarming chondrocytes in situ, but the design of the ...


Sathyamoorthy Sandeep   2013
Accurate prediction of pharmaceutical concentrations in wastewater effluents requires that the specific biochemical processes responsible for pharmaceutical biodegradation be elucidated and integrated within any modeling framework. The fate of three selected beta blockers  atenolol, metoprolol, and sotalol  was examined during nitrification using batch experiments to develop and evaluate ...


Carvalho Susana   2013
The present study analyses the composition, structure and trophic function of epibenthic assemblages in two artificial reefs (ARs) 16 years after deployment and in nearby natural reefs (NRs), aiming at providing insights on the complementarity between both habitats. Current findings suggest that after 16 years the ARs (concrete blocks), located ...


A Comparison of Statistical Methods for Detecting ContextModulated Functional Connectivity in fMRI.
Cisler Josh M   2013
Many cognitive and clinical neuroscience research studies seek to determine how contextual factors modulate cognitive processes. In fMRI, hypotheses about how context modulates distributed patterns of information processing are often tested by comparing functional connectivity between neural regions A and B as a function of task condition X and Y, ...


Salari Nader   2013
The classification of Acute Coronary Syndrome (ACS), using artificial intelligence (AI), has recently drawn the attention of the medical researchers. Using this approach, patients with myocardial infarction can be differentiated from those with unstable angina. The present study aims to develop an integrated model, based on the feature selection and ...


Silva M M   2014
This paper addresses the local identifiability and sensitivity properties of two classes of Wiener models for the neuromuscular blockade and depth of hypnosis, when drug dose profiles like the ones commonly administered in the clinical practice are used as model inputs. The local parameter identifiability was assessed based on the ...


Hansson Mari   2013
Highthroughput screening (HTS) is widely used in the pharmaceutical industry to identify novel chemical starting points for drug discovery projects. The current study focuses on the relationship between molecular hit rate in recent inhouse HTS and four common molecular descriptors: lipophilicity (ClogP), size (heavy atom count, HEV), fraction of sp(3)hybridized ...


El Karoui Noureddine N Department of Statistics, University of California, Berkeley, CA 94720, USA.   2013
We study regression Mestimates in the setting where p, the number of covariates, and n, the number of observations, are both large, but p ≤ n. We find an exact stochastic representation for the distribution of β = argmin(β∈ℝ(p)) Σ(i=1)(n) ρ(Y(i)  X(i')β) at fixed p and n under various ...


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