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El Karoui Noureddine N Department of Statistics, University of California, Berkeley, CA 94720, USA.   2013
We study regression Mestimates in the setting where p, the number of covariates, and n, the number of observations, are both large, but p ≤ n. We find an exact stochastic representation for the distribution of β = argmin(β∈ℝ(p)) Σ(i=1)(n) ρ(Y(i)  X(i')β) at fixed p and n under various ...


Comas J   2013
Field trials may be required to assess risks of genetically modified crops (GMCs) for nontarget arthropods. One critical point of these trials is their capacity to detect differences between the density of one taxon in the GMC and that in the comparator. The detection capacity of a trial depends on ...


Kuss Oliver   2013
There are still challenges when metaanalyzing data from studies on diagnostic accuracy. This is mainly due to the bivariate nature of the response where information on sensitivity and specificity must be summarized while accounting for their correlation within a single trial. In this paper, we propose a new statistical model ...


Automatic Relevance Determination in Nonnegative Matrix Factorization with the $(\beta)$Divergence.
Tan Vincent Y F   2013
This paper addresses the estimation of the latent dimensionality in nonnegative matrix factorization (NMF) with the $(\beta)$divergence. The $(\beta)$divergence is a family of cost functions that includes the squared euclidean distance, KullbackLeibler (KL) and ItakuraSaito (IS) divergences as special cases. Learning the model order is important as it is necessary ...


Legendre Pierre   2013
Beta diversity can be measured in different ways. Among these, the total variance of the community data table Y can be used as an estimate of beta diversity. We show how the total variance of Y can be calculated either directly or through a dissimilarity matrix obtained using any dissimilarity ...


Yang Lingling   2013
Studies have shown that statistically there are differences in theta, alpha and beta band powers when people look at blue and red colors. In this paper, a game has been developed to test whether these statistical differences are good enough for online Brain Computer Interface (BCI) application. We implemented a ...


Horoi M   2013
Neutrinoless double beta decay, if observed, could distinguish whether the neutrino is a Dirac or a Majorana particle, and it could be used to determine the absolute scale of the neutrino masses. ^{136}Xe is one of the most promising candidates for observing this rare event. However, until recently there were ...


El Kerdawy Ahmed   2013
We have used a set of four local properties based on semiempirical molecular orbital calculations (the electron density (ρ), hydrogen bond donor field (HDF), hydrogen bond acceptor field (HAF) and molecular lipophilicity potential (MLP)) for 3DQSAR studies to overcome the limitations of the current forcefield based molecular interaction fields (MIFs). ...


ABCB1 Structural Models, Molecular Docking, and Synthesis of New Oxadiazolothiazin3one Inhibitors.
Rosano Camillo C IRCCS SMIST, U.O.S. Biopolimeri e Proteomica , Largo R. Benzi 10, 16132 Genova,   2013
Docking methods are powerful tools for in silico screening and drug lead generation and optimization. Here, we describe the synthesis of new inhibitors of ABCB1 whose design was based on construction and preliminary confirmation of a model for this membrane transporter of the ATPbinding cassette family. We chose the strategy ...


Xu Xu Steven   2013
Beta regression models have been recommended for continuous bounded outcome scores that are often collected in clinical studies. Implementing beta regression in NONMEM presents difficulties since it does not provide gamma functions required by the beta distribution density function. The objective of the study was to implement mixedeffects beta regression ...


Srinivas Nuggehally R   2013
Ciclesonide, a novel glucocorticosteroid, through a rapid metabolism to desisobutyrylciclesonide (desciclesonide), provides an effective treatment option for asthma episodes by the inhaled route of administration. The availability of pharmacokinetic parameters (clearance [CL/F]; volume of distribution [Vd/F]; elimination halflife [T1/2]; and elimination rate constant [Kel]) in mice, rats, rabbits, and dogs ...


Tulupyev Alexander   2013
Our aim is to model the frequency of certain behavioral acts, especially those that are likely to transmit communicable diseases between persons. We develop a generalized linear model on the basis of the beta prime distribution to model the responses to a survey question of the form, 'When was the ...


Domenech de Cellès Matthieu   2013
BACKGROUND: Extendedspectrum betalactamaseproducing Enterobacteriaceae (ESBLE) are a growing concern in hospitals and the community. How to control the nosocomial ESBLE transmission is a matter of debate. Contact isolation of patients has been recommended but evidence supporting it in nonoutbreak settings has been inconclusive. METHODS: We used stochastic transmission models to ...


Boot Maikel   2013
BACKGROUND: Genes encoding Extended Spectrum Beta Lactamases are usually located on transferable plasmids. Each plasmid contains its own replication mechanism. Carattoli et al. developed an extended PCRbased replicon typing method to characterize and identify the replicons of the major plasmid incompatibility groups in Enterobacteriaceae. Based on this method, we designed ...


Moorthy N S Hari Narayana   2013
Abstract In the present computational analysis, pharmacophorebased active conformer selection method was used to derive active conformers for the physicochemical descriptors calculation. The significant regression models were validated using different validation methods, which provided significant Q(2) values. The distancebased approaches were also used to analyze the discriminant property of the ...


Rocha J Leonel   2013
In this work a new probabilistic and dynamical approach to an extension of the Gompertz law is proposed. A generalized family of probability density functions, designated by Beta • (p,q), which is proportional to the right hand side of the TsoularisWallace model, is studied. In particular, for p=2, the investigation ...


Vojniković Bozo   2013
The authors discussed about the problem of special form in astigmatism classification. This special type of astigmatism is the form of obliquely crossed astigmatism. In which the meridians, major and minor, are not right angles. In this astigmatism is not possible to prescribing for cylindrical (toric) spectacle lens. Authors describe ...


Liu ChuanFen   2013
OBJECTIVE: To illustrate how the analysis of bimodal Ushaped distributed utilization can be modeled with betabinomial regression, which is rarely used in health services research. DATA SOURCES/STUDY SETTING: Veterans Affairs (VA) administrative data and Medicare claims in 20012004 for 11,123 Medicareeligible VA primary care users in 2000. STUDY DESIGN: We ...


Huillet Thierry E   2013
We study a class of coalescents derived from a sampling procedure out of [Formula: see text] i.i.d. Pareto[Formula: see text] random variables, normalized by their sum, including [Formula: see text] sizebiasing on total length effects ([Formula: see text]). Depending on the range of [Formula: see text] we derive the large ...


Yu Xiaoyi X Institute of Refrigeration and Cryogenics, Zhejiang University , Hangzhou, China   2013
Cryopreservation of articular cartilage (AC) has excited great interest due to the practical surgical importance of this tissue. Characterization of permeation kinetics of cryoprotective agents (CPA) in AC is important for designing optimal CPA addition/removal protocols to achieve successful cryopreservation. Permeation is predominantly a mass diffusion process. Since the diffusivity ...


Steinrücken Matthias M Department of Statistics, University of California, 367 Evans Hall MC 3860, Berkeley, CA 947203860, USA.   2013
We apply recently developed inference methods based on general coalescent processes to DNA sequence data obtained from various marine species. Several of these species are believed to exhibit socalled shallow gene genealogies, potentially due to extreme reproductive behaviour, e.g. via Hedgecock's "reproduction sweepstakes". Besides the data analysis, in particular the inference ...


Schmidt Philip J   2013
Doseresponse models are the essential link between exposure assessment and computed risk values in quantitative microbial risk assessment, yet the uncertainty that is inherent to computed risks because the doseresponse model parameters are estimated using limited epidemiological data is rarely quantified. Secondorder risk characterization approaches incorporating uncertainty in doseresponse model ...


Bordonali L   2013
We present a systematic experimental comparison of the superparamagnetic relaxation time constants obtained by means of dynamic magnetic measurements and (1)HNMR relaxometry, on ferritebased nanosystems with different composition, various core sizes and dispersed in different solvents. The application of a heuristic model for the relaxivity allowed a comparison between the ...


Jiang Guoqian   2013
The beta phase of the 11th revision of International Classification of Diseases (ICD11) intends to accept public input through a distributed model of authoring. One of the core use cases is to create textual definitions for the ICD categories. The objective of the present study is to design, develop, and ...


Chen Rongda   2013
Recovery rate is essential to the estimation of the portfolio's loss and economic capital. Neglecting the randomness of the distribution of recovery rate may underestimate the risk. The study introduces two kinds of models of distribution, Beta distribution estimation and kernel density distribution estimation, to simulate the distribution of recovery ...


Schmid Matthias M Department of Medical Informatics, FriedrichAlexander University ErlangenNuremberg, Erlangen, Germany.   2013
Regression analysis with a bounded outcome is a common problem in applied statistics. Typical examples include regression models for percentage outcomes and the analysis of ratings that are measured on a bounded scale. In this paper, we consider beta regression, which is a generalization of logit models to situations where ...


Birkner Thomas T Department of Biostatistics, University of Alabama at Birmingham, Birmingham,   2013
We present a frequentist BernoulliBeta hierarchical model to relax the constant prevalence assumption underlying the traditional prevalence estimation approach based on pooled data. This assumption is called into question when sampling from a large geographic area. Pool screening is a method that combines individual items into pools. Each pool will ...


Ng Bernard B Parietal team, Neurospin, INRIA Saclay, France.   2013
There is a recent trend towards integrating resting state functional magnetic resonance imaging (RSfMRI) and diffusion MRI (dMRI) for brain connectivity estimation, as motivated by how estimates from these modalities are presumably two views reflecting the same underlying brain circuitry. In this paper, we show on a cohort of 60 ...


Elsayed Samir A Mohamed SA Computer Science Department, University of Connecticut, Storrs, CT 06269, Helwan University, Cairo, Egypt   2013
Traditional Associative Classification (AC) algorithms typically search for all possible association rules to find a representative subset of those rules. Since the search space of such rules may grow exponentially as the support threshold decreases, the rules discovery process can be computationally expensive. One effective way to tackle this problem ...


Avila Daile   2012
In this work we apply a mathematical model of photosynthesis to quantify the potential for photosynthetic life in the very Early Archean oceans. We assume the presence of oceanic blockers of ultraviolet radiation, specifically ferrous ions. For this scenario, our results suggest a potential for photosynthetic life greater than or ...


Teschendorff Andrew E   2012
MOTIVATION: The Illumina Infinium 450k DNA Methylation Beadchip is a prime candidate technology for EpigenomeWide Association Studies (EWAS). However, a difficulty associated with these beadarrays is that probes come in two different designs, characterised by widely different DNA methylation distributions and dynamic range, which may bias downstream analyses. A key ...


Hu Haipeng   2012
Abstract: We describe the application of different methods in the development of QSAR models for IKKA and IKKB inhibition. The results show that the best QSAR models provide highly accurate predictions for existing IKK inhibitors. The exceptions, corresponding to 5% of the known collection of inhibitors, are five classes of ...


Xu Weixin   2012
The structural characterization of amyloid fibers is one of the most investigated areas in structural biology. Recently, protofibril models for amylin, i.e., the 37residue human islet amyloid polypeptide or hIAPP were suggested by two groups based on NMR (Luca et al., Biochemistry 2007;46:1350513522) and Xray (Wiltzius et al., Protein Sci ...


Marreiros André C   2012
Parkinson's disease is a common and debilitating condition, caused by aberrant activity in a complex basal gangliathalamocortical circuit. Therapeutic advances rely on characterising interactions in this circuit. However, recording electrophysiological responses over the entire circuit is impractical. Dynamic causal modelling offers largescale models of predictive value based on a limited ...


Pullenayegum Eleanor M   2012
BACKGROUND: Measured utility data have a discrete distribution, and the discreteness is particularly pronounced for EQ5D utilities. Given the discreteness of the data, modeling the distribution parametrically is likely to be difficult. Moreover, since the distribution is bounded, the linearity assumptions made by many models are questionable. This article suggests ...


Steinrücken Matthias   2012
We apply recently developed inference methods based on general coalescent processes to DNA sequence data obtained from various marine species. Several of these species are believed to exhibit socalled shallow gene genealogies, potentially due to extreme reproductive behaviour, e.g. via Hedgecock's "reproduction sweepstakes". Besides the data analysis, in particular the inference ...


Wang Ling   2012
Using a selforganizing map (SOM) and support vector machine, two classification models were built to predict whether a compound is a selective inhibitor toward the two Acylcoenzyme A: cholesterol acyltransferase (ACAT) isozymes, ACAT1 and ACAT2. A dataset of 97 ACAT inhibitors was collected. For each molecule, the global descriptors, 2D ...


Tan Vincent Y F   2012
This paper addresses the estimation of the latent dimensionality in nonnegative matrix factorization (NMF) with the $\beta$divergence. The $\beta$divergence is a family of cost functions that includes the squared Euclidean distance, KullbackLeibler and ItakuraSaito divergences as special cases. Learning the model order is important as it is necessary to strike ...


Sagardia Iban   2013
A new quantitative structure activity relationship (QSAR) model is established for oligopeptides that inhibit angiotensin Iconverting enzyme (ACE). Information concerning the Cterminal pentapeptide is considered to describe the peptide structure in the model. A database is constructed, with 263 ACE inhibitory peptides and 38 physicochemical descriptors, abstracted from the published ...


Cardoso Natali F   2012
Spirulina platensis microalgae (SP) and commercial activated carbon (AC) were compared as adsorbents to remove Reactive Red 120 (RR120) textile dye from aqueous effluents. The batch adsorption system was evaluated in relation to the initial pH, contact time, initial dye concentration and temperature. An alternative kinetic model (general order kinetic ...


Peters Jessica R   2012
Relationships between specific borderline personality disorder (BPD) features and facets of impulsivity (negative and positive urgency, premeditation, perseverance, and sensation seeking) were examined in a sample of 227 undergraduate students, oversampled to include many with elevations on a measure of borderline features. Most facets of impulsivity were positively correlated with ...


Stein Edward   2012
In the normal brain beta band oscillatory activity has been associated with retaining of ongoing motor activities. In Parkinson's disease, enhanced beta band oscillatory activity is displayed across the corticobasal ganglia pathway and is one of the prominent neurophysiological phenomena associated with the disorder. Intraoperative and postoperative recordings of neural ...


Corona Giovanni   2012
Hormones regulate all aspects of male reproduction, from sperm production to sexual drive. Although emerging evidence from animal models and small clinical studies in humans clearly point to a role for several hormones in controlling the ejaculatory process, the exact endocrine mechanisms are unclear. Evidence shows that oxytocin is actively ...


Wise Amber   2012
BACKGROUND: Increasing data on early biological changes from chemical exposures requires new interpretation tools to support decisionmaking. OBJECTIVES: To test the possibility of applying a quantitative approach using human data linking chemical exposures and upstream biological perturbations to overt downstream outcomes. METHODS: Using polychlorinated biphenyl (PCB) exposures and maternal thyroid ...


Boomsma Marjolein J   2012
To establish a multivariate normal tissue complication probability (NTCP) model for radiationinduced hypothyroidism. The thyroidstimulating hormone (TSH) level of 105 patients treated with (chemo) radiation therapy for headandneck cancer was prospectively measured during a median followup of 2.5 years. Hypothyroidism was defined as elevated serum TSH with decreased or normal ...


Mansouri Kamel   2012
Polybrominated diphenyl ethers (PBDEs) are used as flame retardants in textiles, foams and plastics. Highly bioaccumulative with toxic effects including developmental neurotoxicity estrogen and thyroid hormones disruption, they are considered as persistent organic pollutants (POPs) and have been found in human tissues, wildlife and biota worldwide. But only some of ...


Bakhshandeh Mohsen   2012
PURPOSE: To determine the doseresponse relationship of the thyroid for radiationinduced hypothyroidism in headandneck radiation therapy, according to 6 normal tissue complication probability models, and to find the bestfit parameters of the models. METHODS AND MATERIALS: Sixtyfive patients treated with primary or postoperative radiation therapy for various cancers in the ...


Ganswindt André   2012
Abstract Biologically inert material in feces may confound interpretations of noninvasive fecal endocrine data, because it may induce variance related to differences in foraging behavior rather than to differences in endocrine activity. We evaluated two different enzyme immunoassays (EIAs) for the noninvasive evaluation of adrenocortical activity in groundfeeding aardwolves (Proteles ...


Schlenker Evelyn H   2012
Hypothyroidism, subclinical hypothyroidism and euthyroid sick syndrome, are prevalent disorders that affect all body systems including the respiratory system and control of breathing. The purpose of this review article is to discuss the regulation of thyroid hormone production and their function at the cellular level; the many causes of hypothyroidism; ...


Bento J   2012
This work aims at assessing the performance of a portable detection system, equipped with an NaI(Tl) scintillation detector for in vivo thyroid monitoring, which was properly calibrated using an anthropomorphic neck phantom. The anthropomorphic physical phantoms commonly used for the efficiency calibration of in vivo counters often present certain limitations ...


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