Results 51  100 of 2007  
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Wang Ling L Research Center for Drug Discovery & Institute of Human Virology, School of Pharmaceutical Sciences, Sun Yatsen University, Guangzhou,   2014
Mammalian target of rapamycin (mTOR) is a central controller of cell growth, proliferation, metabolism, and angiogenesis. Thus, there is a great deal of interest in developing clinical drugs based on mTOR. In this paper, in silico models based on multiscaffolds were developed to predict mTOR inhibitors or noninhibitors. First 1,264 ...


Raineri Emanuele E Statistical Genomics, Centro Nacional de Análisis Genómico, Barcelona, Catalonia,   2014
We apply a known algorithm for computing exactly inequalities between Beta distributions to assess whether a given position in a genome is differentially methylated across samples. We discuss the advantages brought by the adoption of this solution with respect to two approximations (Fisher's test and Z score). The same formalism ...


Tseng KuoKun KK 0000000262587009 Harbin Institute of Technology, Shenzhen Graduate School, Shenzhen,   2014
In recent years, many approaches have been suggested for Internet and web streaming detection. In this paper, we propose an approach to signal waveform detection for Internet and web streaming, with novel statistical automatons. The system records network connections over a period of time to form a signal waveform and ...


Zheng Bojin B 1] College of Computer Science, SouthCentral University For Nationalities, Wuhan 430074, China [2] State Key Laboratory of Networking and Switching Technology, Beijing University of Posts and Telecommunications, Beijing 100876, China [3] Computer School, Wuhan University, Wuhan 430072,   2014
Realworld networks such as the Internet and WWW have many common traits. Until now, hundreds of models were proposed to characterize these traits for understanding the networks. Because different models used very different mechanisms, it is widely believed that these traits origin from different causes. However, we find that a ...


Erben Ulrike U Department of Medicine I for Gastroenterology, Infectious Disease and Rheumatology, Campus Benjamin Franklin, CharitéUniversitätsmedizin Berlin Berlin, Germany ; Research Center ImmunoSciences, CharitéUniversitätsmedizin Berlin Berlin,   2014
Histomorphology remains a powerful routine evaluating intestinal inflammation in animal models. Emphasizing the focus of a given animal study, histopathology can overstate differences between established models. We aimed to systematize histopathological evaluation of intestinal inflammation in mouse models facilitating interstudy comparisons. Samples of all parts of the intestinal tract from ...


Erickson Wallace P WP Western EcoSystems Technology, Inc., Cheyenne, WY, United States of   2014
Small passerines, sometimes referred to as perching birds or songbirds, are the most abundant bird group in the United States (US) and Canada, and the most common among bird fatalities caused by collision with turbines at wind energy facilities. We used data compiled from 116 studies conducted in the US ...


Kanoatov Mirzo   2013
We describe a mathematical approach that enables extraction of kinetic rate constants from thousands of studies conducted over the past two decades with affinity capillary electrophoresis (ACE). Previously, ACE has been used almost exclusively for obtaining equilibrium constants of intermolecular interactions. In this article, we prove that there exists an ...


Noel Yvonnick   2013
An unfolding model for continuous bounded responses is proposed, derived both from a hypothetical interpolation response mechanism and from the hypothesis of two opposite sources of item refusal being collapsed. These two sources of refusal are made explicit in a threecomponent Dirichlet response model and then collapsed to obtain a (twocomponent) beta response ...


Stanga D D National Institute of R&D for Physics and Nuclear Engineering "HoriaHulubei", IFINHH, P.O.Box MG6, BucharestMagurele R077125, Romania. Electronic address:   2013
A simple method has been developed for determining the activity of largearea beta reference sources in anodized aluminum foils. It is based on the modeling of the transmission of beta rays through thin foils in planar geometry using Monte Carlo simulation. The method was checked experimentally and measurement results show ...


Iknayan Kelly J   2013
Estimates of species richness and diversity are central to community and macroecology and are frequently used in conservation planning. Commonly used diversity metrics account for undetected species primarily by controlling for sampling effort. Yet the probability of detecting an individual can vary among species, observers, survey methods, and sites. We ...


Havelka Miroslav M Czech Metrology Institute, Inspectorate for Ionizing Radiation, Radiová 1, 102 00 Prague, Czech Republic. Electronic address:   2013
The activity of the radionuclide (64)Cu was determined by the efficiency extrapolation method applied to 4π(PC)γ coincidence counting. The standardisation was performed by software coincidence countinga digital method for primary activity measurement that simplifies the setting of optimal coincidence parameters. The γrayenergy window, characterised by identical gamma detection efficiency related ...


Lee ChangHyun   2013
The sylvian arachnoid cyst (AC) is a common benign disease; however, it sometimes leads to subdural or intracystic hemorrhage without major trauma. The reason of easy bleeding of the AC is not fully understood. The purpose of this study was to investigate the bleeding mechanism of the sylvian AC in ...


Hardy J C   2013
Because of angularmomentum conservation, superallowed β decay between 0(+) analog states involves only the vector part of the weak interaction, so its measured ft value can be used to determine the vector coupling constant, GV. If many such transitions are measured, then the constancy of GV can be established and ...


Battisti Sabrina   2013
In May 2005, betahexachlorocyclohexane (βHCH) was found in a sample of bovine bulk milk from a farm in the Sacco River valley (Latium region, central Italy). The primary source of contamination was suspected to be industrial discharge into the environment with the Sacco River as the main mean of dispersion. ...


Wentao Fan   2013
A large class of problems can be formulated in terms of the clustering process. Mixture models are an increasingly important tool in statistical pattern recognition and for analyzing and clustering complex data. Two challenging aspects that should be addressed when considering mixture models are how to choose between a set ...


Kalantari Mojgan M Department of Radiology, Mahdiyeh Hospital, Shahid Beheshti University of Medical Sciences, Tehran,   2013
Abdominal circumference (AC), biparietal diameters (BPD) and femoral length (FL) are now the main parameters used to obtain estimated fetal weight (EFW). Although the role of soft tissue parameters in determining fetal weight was proved but clinical attention to midthigh soft tissue thickness (STT) is limited. To find the impression ...


Zhou Mingyuan   2013
The seemingly disjoint problems of count and mixture modeling are united under the negative binomial (NB) process. A gamma process is employed to model the rate measure of a Poisson process, whose normalization provides a random probability measure for mixture modeling and whose marginalization leads to a NB process for ...


He Wenqi   2013
We comment on the recent Letter, by Liu et al. [Opt. Lett.38, 1651 (2013)] in which a method to improve the security strength of the asymmetric cryptosystem (ACS) by Qin and Peng [Opt. Lett.35, 118 (2010)] was proposed. However, in accordance with Liu's methodology, we could easily find other more efficient ...


Yu Xiaoyi   2013
Longterm storage of articular cartilage (AC) has excited great interest due to the practical surgical significance of this tissue. The liquidustracking (LT) method developed by Pegg et al. [Cryobiology, 52 (2006) 360368] for vitreous preservation of AC achieved reasonable survival of postwarming chondrocytes in situ, but the design of the ...


Sathyamoorthy Sandeep   2013
Accurate prediction of pharmaceutical concentrations in wastewater effluents requires that the specific biochemical processes responsible for pharmaceutical biodegradation be elucidated and integrated within any modeling framework. The fate of three selected beta blockers  atenolol, metoprolol, and sotalol  was examined during nitrification using batch experiments to develop and evaluate ...


Carvalho Susana   2013
The present study analyses the composition, structure and trophic function of epibenthic assemblages in two artificial reefs (ARs) 16 years after deployment and in nearby natural reefs (NRs), aiming at providing insights on the complementarity between both habitats. Current findings suggest that after 16 years the ARs (concrete blocks), located ...


A Comparison of Statistical Methods for Detecting ContextModulated Functional Connectivity in fMRI.
Cisler Josh M   2013
Many cognitive and clinical neuroscience research studies seek to determine how contextual factors modulate cognitive processes. In fMRI, hypotheses about how context modulates distributed patterns of information processing are often tested by comparing functional connectivity between neural regions A and B as a function of task condition X and Y, ...


Salari Nader   2013
The classification of Acute Coronary Syndrome (ACS), using artificial intelligence (AI), has recently drawn the attention of the medical researchers. Using this approach, patients with myocardial infarction can be differentiated from those with unstable angina. The present study aims to develop an integrated model, based on the feature selection and ...


Silva M M   2014
This paper addresses the local identifiability and sensitivity properties of two classes of Wiener models for the neuromuscular blockade and depth of hypnosis, when drug dose profiles like the ones commonly administered in the clinical practice are used as model inputs. The local parameter identifiability was assessed based on the ...


Hansson Mari   2013
Highthroughput screening (HTS) is widely used in the pharmaceutical industry to identify novel chemical starting points for drug discovery projects. The current study focuses on the relationship between molecular hit rate in recent inhouse HTS and four common molecular descriptors: lipophilicity (ClogP), size (heavy atom count, HEV), fraction of sp(3)hybridized ...


El Karoui Noureddine N Department of Statistics, University of California, Berkeley, CA 94720, USA.   2013
We study regression Mestimates in the setting where p, the number of covariates, and n, the number of observations, are both large, but p ≤ n. We find an exact stochastic representation for the distribution of β = argmin(β∈ℝ(p)) Σ(i=1)(n) ρ(Y(i)  X(i')β) at fixed p and n under various ...


Comas J   2013
Field trials may be required to assess risks of genetically modified crops (GMCs) for nontarget arthropods. One critical point of these trials is their capacity to detect differences between the density of one taxon in the GMC and that in the comparator. The detection capacity of a trial depends on ...


  2013
Success often comes through many small, incremental, wellexecuted improvements.


Kuss Oliver   2013
There are still challenges when metaanalyzing data from studies on diagnostic accuracy. This is mainly due to the bivariate nature of the response where information on sensitivity and specificity must be summarized while accounting for their correlation within a single trial. In this paper, we propose a new statistical model ...


Automatic Relevance Determination in Nonnegative Matrix Factorization with the $(\beta)$Divergence.
Tan Vincent Y F   2013
This paper addresses the estimation of the latent dimensionality in nonnegative matrix factorization (NMF) with the $(\beta)$divergence. The $(\beta)$divergence is a family of cost functions that includes the squared euclidean distance, KullbackLeibler (KL) and ItakuraSaito (IS) divergences as special cases. Learning the model order is important as it is necessary ...


Legendre Pierre   2013
Beta diversity can be measured in different ways. Among these, the total variance of the community data table Y can be used as an estimate of beta diversity. We show how the total variance of Y can be calculated either directly or through a dissimilarity matrix obtained using any dissimilarity ...


Yang Lingling   2013
Studies have shown that statistically there are differences in theta, alpha and beta band powers when people look at blue and red colors. In this paper, a game has been developed to test whether these statistical differences are good enough for online Brain Computer Interface (BCI) application. We implemented a ...


Horoi M   2013
Neutrinoless double beta decay, if observed, could distinguish whether the neutrino is a Dirac or a Majorana particle, and it could be used to determine the absolute scale of the neutrino masses. ^{136}Xe is one of the most promising candidates for observing this rare event. However, until recently there were ...


El Kerdawy Ahmed   2013
We have used a set of four local properties based on semiempirical molecular orbital calculations (the electron density (ρ), hydrogen bond donor field (HDF), hydrogen bond acceptor field (HAF) and molecular lipophilicity potential (MLP)) for 3DQSAR studies to overcome the limitations of the current forcefield based molecular interaction fields (MIFs). ...


ABCB1 Structural Models, Molecular Docking, and Synthesis of New Oxadiazolothiazin3one Inhibitors.
Rosano Camillo C IRCCS SMIST, U.O.S. Biopolimeri e Proteomica , Largo R. Benzi 10, 16132 Genova,   2013
Docking methods are powerful tools for in silico screening and drug lead generation and optimization. Here, we describe the synthesis of new inhibitors of ABCB1 whose design was based on construction and preliminary confirmation of a model for this membrane transporter of the ATPbinding cassette family. We chose the strategy ...


Xu Xu Steven   2013
Beta regression models have been recommended for continuous bounded outcome scores that are often collected in clinical studies. Implementing beta regression in NONMEM presents difficulties since it does not provide gamma functions required by the beta distribution density function. The objective of the study was to implement mixedeffects beta regression ...


Srinivas Nuggehally R   2013
Ciclesonide, a novel glucocorticosteroid, through a rapid metabolism to desisobutyrylciclesonide (desciclesonide), provides an effective treatment option for asthma episodes by the inhaled route of administration. The availability of pharmacokinetic parameters (clearance [CL/F]; volume of distribution [Vd/F]; elimination halflife [T1/2]; and elimination rate constant [Kel]) in mice, rats, rabbits, and dogs ...


Tulupyev Alexander   2013
Our aim is to model the frequency of certain behavioral acts, especially those that are likely to transmit communicable diseases between persons. We develop a generalized linear model on the basis of the beta prime distribution to model the responses to a survey question of the form, 'When was the ...


Domenech de Cellès Matthieu   2013
BACKGROUND: Extendedspectrum betalactamaseproducing Enterobacteriaceae (ESBLE) are a growing concern in hospitals and the community. How to control the nosocomial ESBLE transmission is a matter of debate. Contact isolation of patients has been recommended but evidence supporting it in nonoutbreak settings has been inconclusive. METHODS: We used stochastic transmission models to ...


Boot Maikel   2013
BACKGROUND: Genes encoding Extended Spectrum Beta Lactamases are usually located on transferable plasmids. Each plasmid contains its own replication mechanism. Carattoli et al. developed an extended PCRbased replicon typing method to characterize and identify the replicons of the major plasmid incompatibility groups in Enterobacteriaceae. Based on this method, we designed ...


Moorthy N S Hari Narayana   2013
Abstract In the present computational analysis, pharmacophorebased active conformer selection method was used to derive active conformers for the physicochemical descriptors calculation. The significant regression models were validated using different validation methods, which provided significant Q(2) values. The distancebased approaches were also used to analyze the discriminant property of the ...


Rocha J Leonel   2013
In this work a new probabilistic and dynamical approach to an extension of the Gompertz law is proposed. A generalized family of probability density functions, designated by Beta • (p,q), which is proportional to the right hand side of the TsoularisWallace model, is studied. In particular, for p=2, the investigation ...


Vojniković Bozo   2013
The authors discussed about the problem of special form in astigmatism classification. This special type of astigmatism is the form of obliquely crossed astigmatism. In which the meridians, major and minor, are not right angles. In this astigmatism is not possible to prescribing for cylindrical (toric) spectacle lens. Authors describe ...


Liu ChuanFen   2013
OBJECTIVE: To illustrate how the analysis of bimodal Ushaped distributed utilization can be modeled with betabinomial regression, which is rarely used in health services research. DATA SOURCES/STUDY SETTING: Veterans Affairs (VA) administrative data and Medicare claims in 20012004 for 11,123 Medicareeligible VA primary care users in 2000. STUDY DESIGN: We ...


Huillet Thierry E   2013
We study a class of coalescents derived from a sampling procedure out of [Formula: see text] i.i.d. Pareto[Formula: see text] random variables, normalized by their sum, including [Formula: see text] sizebiasing on total length effects ([Formula: see text]). Depending on the range of [Formula: see text] we derive the large ...


Yu Xiaoyi X Institute of Refrigeration and Cryogenics, Zhejiang University , Hangzhou, China   2013
Cryopreservation of articular cartilage (AC) has excited great interest due to the practical surgical importance of this tissue. Characterization of permeation kinetics of cryoprotective agents (CPA) in AC is important for designing optimal CPA addition/removal protocols to achieve successful cryopreservation. Permeation is predominantly a mass diffusion process. Since the diffusivity ...


Steinrücken Matthias M Department of Statistics, University of California, 367 Evans Hall MC 3860, Berkeley, CA 947203860, USA.   2013
We apply recently developed inference methods based on general coalescent processes to DNA sequence data obtained from various marine species. Several of these species are believed to exhibit socalled shallow gene genealogies, potentially due to extreme reproductive behaviour, e.g. via Hedgecock's "reproduction sweepstakes". Besides the data analysis, in particular the inference ...


Schmidt Philip J   2013
Doseresponse models are the essential link between exposure assessment and computed risk values in quantitative microbial risk assessment, yet the uncertainty that is inherent to computed risks because the doseresponse model parameters are estimated using limited epidemiological data is rarely quantified. Secondorder risk characterization approaches incorporating uncertainty in doseresponse model ...


Bordonali L   2013
We present a systematic experimental comparison of the superparamagnetic relaxation time constants obtained by means of dynamic magnetic measurements and (1)HNMR relaxometry, on ferritebased nanosystems with different composition, various core sizes and dispersed in different solvents. The application of a heuristic model for the relaxivity allowed a comparison between the ...


Jiang Guoqian   2013
The beta phase of the 11th revision of International Classification of Diseases (ICD11) intends to accept public input through a distributed model of authoring. One of the core use cases is to create textual definitions for the ICD categories. The objective of the present study is to design, develop, and ...


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