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 Results 51 - 100 of 1987 1 2 3 4 5 6 7 8 9 10 > 51 Yu Xiaoyi - - 2013 Long-term storage of articular cartilage (AC) has excited great interest due to the practical surgical significance of this tissue. The liquidus-tracking (LT) method developed by Pegg et al. [Cryobiology, 52 (2006) 360-368] for vitreous preservation of AC achieved reasonable survival of post-warming chondrocytes in situ, but the design of the ... 52 Sathyamoorthy Sandeep - - 2013 Accurate prediction of pharmaceutical concentrations in wastewater effluents requires that the specific biochemical processes responsible for pharmaceutical biodegradation be elucidated and integrated within any modeling framework. The fate of three selected beta blockers - atenolol, metoprolol, and sotalol - was examined during nitrification using batch experiments to develop and evaluate ... 53 Carvalho Susana - - 2013 The present study analyses the composition, structure and trophic function of epibenthic assemblages in two artificial reefs (ARs) 16 years after deployment and in nearby natural reefs (NRs), aiming at providing insights on the complementarity between both habitats. Current findings suggest that after 16 years the ARs (concrete blocks), located ... 54 Cisler Josh M - - 2013 Many cognitive and clinical neuroscience research studies seek to determine how contextual factors modulate cognitive processes. In fMRI, hypotheses about how context modulates distributed patterns of information processing are often tested by comparing functional connectivity between neural regions A and B as a function of task condition X and Y, ... 55 Salari Nader - - 2013 The classification of Acute Coronary Syndrome (ACS), using artificial intelligence (AI), has recently drawn the attention of the medical researchers. Using this approach, patients with myocardial infarction can be differentiated from those with unstable angina. The present study aims to develop an integrated model, based on the feature selection and ... 56 Silva M M - - 2014 This paper addresses the local identifiability and sensitivity properties of two classes of Wiener models for the neuromuscular blockade and depth of hypnosis, when drug dose profiles like the ones commonly administered in the clinical practice are used as model inputs. The local parameter identifiability was assessed based on the ... 57 Hansson Mari - - 2013 High-throughput screening (HTS) is widely used in the pharmaceutical industry to identify novel chemical starting points for drug discovery projects. The current study focuses on the relationship between molecular hit rate in recent in-house HTS and four common molecular descriptors: lipophilicity (ClogP), size (heavy atom count, HEV), fraction of sp(3)-hybridized ... 58 El Karoui Noureddine N Department of Statistics, University of California, Berkeley, CA 94720, USA. - - 2013 We study regression M-estimates in the setting where p, the number of covariates, and n, the number of observations, are both large, but p ≤ n. We find an exact stochastic representation for the distribution of β = argmin(β∈ℝ(p)) Σ(i=1)(n) ρ(Y(i) - X(i')β) at fixed p and n under various ... 59 Comas J - - 2013 Field trials may be required to assess risks of genetically modified crops (GMCs) for nontarget arthropods. One critical point of these trials is their capacity to detect differences between the density of one taxon in the GMC and that in the comparator. The detection capacity of a trial depends on ... 60 Kuss Oliver - - 2013 There are still challenges when meta-analyzing data from studies on diagnostic accuracy. This is mainly due to the bivariate nature of the response where information on sensitivity and specificity must be summarized while accounting for their correlation within a single trial. In this paper, we propose a new statistical model ... 61 Tan Vincent Y F - - 2013 This paper addresses the estimation of the latent dimensionality in nonnegative matrix factorization (NMF) with the $(\beta)$--divergence. The $(\beta)$-divergence is a family of cost functions that includes the squared euclidean distance, Kullback-Leibler (KL) and Itakura-Saito (IS) divergences as special cases. Learning the model order is important as it is necessary ... 62 Legendre Pierre - - 2013 Beta diversity can be measured in different ways. Among these, the total variance of the community data table Y can be used as an estimate of beta diversity. We show how the total variance of Y can be calculated either directly or through a dissimilarity matrix obtained using any dissimilarity ... 63 Yang Lingling - - 2013 Studies have shown that statistically there are differences in theta, alpha and beta band powers when people look at blue and red colors. In this paper, a game has been developed to test whether these statistical differences are good enough for online Brain Computer Interface (BCI) application. We implemented a ... 64 Horoi M - - 2013 Neutrinoless double beta decay, if observed, could distinguish whether the neutrino is a Dirac or a Majorana particle, and it could be used to determine the absolute scale of the neutrino masses. ^{136}Xe is one of the most promising candidates for observing this rare event. However, until recently there were ... 65 El Kerdawy Ahmed - - 2013 We have used a set of four local properties based on semiempirical molecular orbital calculations (the electron density (ρ), hydrogen bond donor field (HDF), hydrogen bond acceptor field (HAF) and molecular lipophilicity potential (MLP)) for 3D-QSAR studies to overcome the limitations of the current force-field based molecular interaction fields (MIFs). ... 66 Rosano Camillo C IRCCS SM-IST, U.O.S. Biopolimeri e Proteomica , Largo R. Benzi 10, 16132 Genova, - - 2013 Docking methods are powerful tools for in silico screening and drug lead generation and optimization. Here, we describe the synthesis of new inhibitors of ABCB1 whose design was based on construction and preliminary confirmation of a model for this membrane transporter of the ATP-binding cassette family. We chose the strategy ... 67 Xu Xu Steven - - 2013 Beta regression models have been recommended for continuous bounded outcome scores that are often collected in clinical studies. Implementing beta regression in NONMEM presents difficulties since it does not provide gamma functions required by the beta distribution density function. The objective of the study was to implement mixed-effects beta regression ... 68 Srinivas Nuggehally R - - 2013 Ciclesonide, a novel glucocorticosteroid, through a rapid metabolism to desisobutyryl-ciclesonide (des-ciclesonide), provides an effective treatment option for asthma episodes by the inhaled route of administration. The availability of pharmacokinetic parameters (clearance [CL/F]; volume of distribution [Vd/F]; elimination half-life [T1/2]; and elimination rate constant [Kel]) in mice, rats, rabbits, and dogs ... 69 Tulupyev Alexander - - 2013 Our aim is to model the frequency of certain behavioral acts, especially those that are likely to transmit communicable diseases between persons. We develop a generalized linear model on the basis of the beta prime distribution to model the responses to a survey question of the form, 'When was the ... 70 Domenech de Cellès Matthieu - - 2013 BACKGROUND: Extended-spectrum beta-lactamase--producing Enterobacteriaceae (ESBL-E) are a growing concern in hospitals and the community. How to control the nosocomial ESBL-E transmission is a matter of debate. Contact isolation of patients has been recommended but evidence supporting it in non-outbreak settings has been inconclusive. METHODS: We used stochastic transmission models to ... 71 Boot Maikel - - 2013 BACKGROUND: Genes encoding Extended Spectrum Beta Lactamases are usually located on transferable plasmids. Each plasmid contains its own replication mechanism. Carattoli et al. developed an extended PCR-based replicon typing method to characterize and identify the replicons of the major plasmid incompatibility groups in Enterobacteriaceae. Based on this method, we designed ... 72 Moorthy N S Hari Narayana - - 2013 Abstract In the present computational analysis, pharmacophore-based active conformer selection method was used to derive active conformers for the physicochemical descriptors calculation. The significant regression models were validated using different validation methods, which provided significant Q(2) values. The distance-based approaches were also used to analyze the discriminant property of the ... 73 Rocha J Leonel - - 2013 In this work a new probabilistic and dynamical approach to an extension of the Gompertz law is proposed. A generalized family of probability density functions, designated by Beta • (p,q), which is proportional to the right hand side of the Tsoularis-Wallace model, is studied. In particular, for p=2, the investigation ... 74 Vojniković Bozo - - 2013 The authors discussed about the problem of special form in astigmatism classification. This special type of astigmatism is the form of obliquely crossed astigmatism. In which the meridians, major and minor, are not right angles. In this astigmatism is not possible to prescribing for cylindrical (toric) spectacle lens. Authors describe ... 75 Liu Chuan-Fen - - 2013 OBJECTIVE: To illustrate how the analysis of bimodal U-shaped distributed utilization can be modeled with beta-binomial regression, which is rarely used in health services research. DATA SOURCES/STUDY SETTING: Veterans Affairs (VA) administrative data and Medicare claims in 2001-2004 for 11,123 Medicare-eligible VA primary care users in 2000. STUDY DESIGN: We ... 76 Huillet Thierry E - - 2013 We study a class of coalescents derived from a sampling procedure out of [Formula: see text] i.i.d. Pareto[Formula: see text] random variables, normalized by their sum, including [Formula: see text] -size-biasing on total length effects ([Formula: see text]). Depending on the range of [Formula: see text] we derive the large ... 77 Yu Xiaoyi X Institute of Refrigeration and Cryogenics, Zhejiang University , Hangzhou, China - - 2013 Cryopreservation of articular cartilage (AC) has excited great interest due to the practical surgical importance of this tissue. Characterization of permeation kinetics of cryoprotective agents (CPA) in AC is important for designing optimal CPA addition/removal protocols to achieve successful cryopreservation. Permeation is predominantly a mass diffusion process. Since the diffusivity ... 78 Steinrücken Matthias M Department of Statistics, University of California, 367 Evans Hall MC 3860, Berkeley, CA 94720-3860, USA. - - 2013 We apply recently developed inference methods based on general coalescent processes to DNA sequence data obtained from various marine species. Several of these species are believed to exhibit so-called shallow gene genealogies, potentially due to extreme reproductive behaviour, e.g. via Hedgecock's "reproduction sweepstakes". Besides the data analysis, in particular the inference ... 79 Schmidt Philip J - - 2013 Dose-response models are the essential link between exposure assessment and computed risk values in quantitative microbial risk assessment, yet the uncertainty that is inherent to computed risks because the dose-response model parameters are estimated using limited epidemiological data is rarely quantified. Second-order risk characterization approaches incorporating uncertainty in dose-response model ... 80 Bordonali L - - 2013 We present a systematic experimental comparison of the superparamagnetic relaxation time constants obtained by means of dynamic magnetic measurements and (1)H-NMR relaxometry, on ferrite-based nanosystems with different composition, various core sizes and dispersed in different solvents. The application of a heuristic model for the relaxivity allowed a comparison between the ... 81 Jiang Guoqian - - 2013 The beta phase of the 11th revision of International Classification of Diseases (ICD-11) intends to accept public input through a distributed model of authoring. One of the core use cases is to create textual definitions for the ICD categories. The objective of the present study is to design, develop, and ... 82 Chen Rongda - - 2013 Recovery rate is essential to the estimation of the portfolio's loss and economic capital. Neglecting the randomness of the distribution of recovery rate may underestimate the risk. The study introduces two kinds of models of distribution, Beta distribution estimation and kernel density distribution estimation, to simulate the distribution of recovery ... 83 Schmid Matthias M Department of Medical Informatics, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany. - - 2013 Regression analysis with a bounded outcome is a common problem in applied statistics. Typical examples include regression models for percentage outcomes and the analysis of ratings that are measured on a bounded scale. In this paper, we consider beta regression, which is a generalization of logit models to situations where ... 84 Birkner Thomas T Department of Biostatistics, University of Alabama at Birmingham, Birmingham, - - 2013 We present a frequentist Bernoulli-Beta hierarchical model to relax the constant prevalence assumption underlying the traditional prevalence estimation approach based on pooled data. This assumption is called into question when sampling from a large geographic area. Pool screening is a method that combines individual items into pools. Each pool will ... 85 Ng Bernard B Parietal team, Neurospin, INRIA Saclay, France. - - 2013 There is a recent trend towards integrating resting state functional magnetic resonance imaging (RS-fMRI) and diffusion MRI (dMRI) for brain connectivity estimation, as motivated by how estimates from these modalities are presumably two views reflecting the same underlying brain circuitry. In this paper, we show on a cohort of 60 ... 86 Elsayed Samir A Mohamed SA Computer Science Department, University of Connecticut, Storrs, CT 06269, Helwan University, Cairo, Egypt - - 2013 Traditional Associative Classification (AC) algorithms typically search for all possible association rules to find a representative subset of those rules. Since the search space of such rules may grow exponentially as the support threshold decreases, the rules discovery process can be computationally expensive. One effective way to tackle this problem ... 87 Avila Daile - - 2012 In this work we apply a mathematical model of photosynthesis to quantify the potential for photosynthetic life in the very Early Archean oceans. We assume the presence of oceanic blockers of ultraviolet radiation, specifically ferrous ions. For this scenario, our results suggest a potential for photosynthetic life greater than or ... 88 Teschendorff Andrew E - - 2012 MOTIVATION: The Illumina Infinium 450k DNA Methylation Beadchip is a prime candidate technology for Epigenome-Wide Association Studies (EWAS). However, a difficulty associated with these beadarrays is that probes come in two different designs, characterised by widely different DNA methylation distributions and dynamic range, which may bias downstream analyses. A key ... 89 Hu Haipeng - - 2012 Abstract: We describe the application of different methods in the development of QSAR models for IKKA and IKKB inhibition. The results show that the best QSAR models provide highly accurate predictions for existing IKK inhibitors. The exceptions, corresponding to 5% of the known collection of inhibitors, are five classes of ... 90 Xu Weixin - - 2012 The structural characterization of amyloid fibers is one of the most investigated areas in structural biology. Recently, protofibril models for amylin, i.e., the 37-residue human islet amyloid polypeptide or hIAPP were suggested by two groups based on NMR (Luca et al., Biochemistry 2007;46:13505-13522) and X-ray (Wiltzius et al., Protein Sci ... 91 Marreiros André C - - 2012 Parkinson's disease is a common and debilitating condition, caused by aberrant activity in a complex basal ganglia-thalamocortical circuit. Therapeutic advances rely on characterising interactions in this circuit. However, recording electrophysiological responses over the entire circuit is impractical. Dynamic causal modelling offers large-scale models of predictive value based on a limited ... 92 Pullenayegum Eleanor M - - 2012 BACKGROUND: Measured utility data have a discrete distribution, and the discreteness is particularly pronounced for EQ-5D utilities. Given the discreteness of the data, modeling the distribution parametrically is likely to be difficult. Moreover, since the distribution is bounded, the linearity assumptions made by many models are questionable. This article suggests ... 93 Steinrücken Matthias - - 2012 We apply recently developed inference methods based on general coalescent processes to DNA sequence data obtained from various marine species. Several of these species are believed to exhibit so-called shallow gene genealogies, potentially due to extreme reproductive behaviour, e.g. via Hedgecock's "reproduction sweepstakes". Besides the data analysis, in particular the inference ... 94 Wang Ling - - 2012 Using a self-organizing map (SOM) and support vector machine, two classification models were built to predict whether a compound is a selective inhibitor toward the two Acyl-coenzyme A: cholesterol acyltransferase (ACAT) isozymes, ACAT-1 and ACAT-2. A dataset of 97 ACAT inhibitors was collected. For each molecule, the global descriptors, 2D ... 95 Tan Vincent Y F - - 2012 This paper addresses the estimation of the latent dimensionality in nonnegative matrix factorization (NMF) with the $\beta$-divergence. The $\beta$-divergence is a family of cost functions that includes the squared Euclidean distance, Kullback-Leibler and Itakura-Saito divergences as special cases. Learning the model order is important as it is necessary to strike ... 96 Sagardia Iban - - 2013 A new quantitative structure activity relationship (QSAR) model is established for oligopeptides that inhibit angiotensin I-converting enzyme (ACE). Information concerning the C-terminal pentapeptide is considered to describe the peptide structure in the model. A database is constructed, with 263 ACE inhibitory peptides and 38 physicochemical descriptors, abstracted from the published ... 97 Parsons-Wingerter Patricia P Research & Technology Directorate, John H. Glenn Research Center, National Aeronautics and Space Administration, Cleveland, OH - - 2012 Challenges to long-duration space exploration and colonization in microgravity and cosmic radiation environments by humans include poorly understood risks for gastrointestinal function and cancer. Nonetheless, constant remodeling of the intestinal microvasculature is critical for tissue viability, healthy wound healing, and successful prevention or recovery from vascular-mediated inflammatory or ischemic diseases ... 98 Cardoso Natali F - - 2012 Spirulina platensis microalgae (SP) and commercial activated carbon (AC) were compared as adsorbents to remove Reactive Red 120 (RR-120) textile dye from aqueous effluents. The batch adsorption system was evaluated in relation to the initial pH, contact time, initial dye concentration and temperature. An alternative kinetic model (general order kinetic ... 99 Peters Jessica R - - 2012 Relationships between specific borderline personality disorder (BPD) features and facets of impulsivity (negative and positive urgency, premeditation, perseverance, and sensation seeking) were examined in a sample of 227 undergraduate students, oversampled to include many with elevations on a measure of borderline features. Most facets of impulsivity were positively correlated with ... 100 Stein Edward - - 2012 In the normal brain beta band oscillatory activity has been associated with retaining of ongoing motor activities. In Parkinson's disease, enhanced beta band oscillatory activity is displayed across the cortico-basal ganglia pathway and is one of the prominent neurophysiological phenomena associated with the disorder. Intraoperative and postoperative recordings of neural ... 1 2 3 4 5 6 7 8 9 10 >