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Results 401 - 450 of 2728
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Chen Feng - - 2011
In adverse driving conditions, such as inclement weather and/or complex terrain, trucks are often involved in single-vehicle (SV) accidents in addition to multi-vehicle (MV) accidents. Ten-year accident data involving trucks on rural highway from the Highway Safety Information System (HSIS) is studied to investigate the difference in driver-injury severity between ...
Tarko Andrew - - 2011
Evaluation of crash-related injuries by medical specialists in hospitals is believed to be more exact than rather a cursory evaluation made at the crash scene. Safety analysts sometimes reach for hospital data and use them in combination with the police crash data. One issue that needs to be addressed is ...
Schoborg R V - - 2011
Under stress, chlamydiae can enter a non-infectious but viable state termed persistence. In the absence of a tractable genetic system, persistence induction provides an important experimental tool with which to study these fascinating organisms. This review will discuss examples of: i) persistence studies that have illuminated critical chlamydiae/host interactions; and ...
Alexander M S - - 2011
Objective:To create the International Spinal Cord Injury (SCI) Female Sexual and Reproductive Function Basic Data Set within the International SCI Data Sets.Setting:An international working group.Methods:The draft of the data set was developed by an international working group consisting of members appointed by the International Spinal Cord Society (ISCoS), the American ...
Lang D L - - 2011
This cross-sectional study identified the prevalence and correlates of condom-use errors among female sex workers (FSWs) in Armenia. One hundred and seventeen street-based FSWs aged 20-52 years completed an interviewer-administered questionnaire. Condom-use errors were reported by 78.0% of participants. Number of clients, higher frequency of condom application on clients by ...
Funatsu Kimito - - 2011
The first step in the process of drug development is to determine those lead compounds that demonstrate significant biological activity with regard to a target protein. Because this process is often costly and time consuming, there is a need to develop efficient methodologies for the generation of lead compounds for ...
Weissing Franz J - - 2011
Speciation-the origin of new species-is the source of the diversity of life. A theory of speciation is essential to link poorly understood macro-evolutionary processes, such as the origin of biodiversity and adaptive radiation, to well understood micro-evolutionary processes, such as allele frequency change due to natural or sexual selection. An ...
Hayes Richard D - - 2011
There is debate in the scientific literature regarding which model most accurately represents the female sexual response. Traditionally, sex research has been conducted within the framework of the linear sexual response model proposed by Masters and Johnson, modified by Kaplan, then Robinson. Criticism of linear models prompted the development of ...
Lam Fumei - - 2011
Abstract Given molecular genetic data from diploid individuals that, at present, reproduce mostly or exclusively asexually without recombination, an important problem in evolutionary biology is detecting evidence of past sexual reproduction (i.e., meiosis and mating) and recombination (both meiotic and mitotic). However, currently there is a lack of computational tools ...
de Oliveira Nelson Luiz Batista NL Departamento de Enfermagem, Universidade Estadual de Maringá, PR, Brazil. - - 2011
This study characterizes traffic accidents involving motorcycles according to local conditions, data concerning the type of accident, date and time, and identifies among these variables those associated with the death of victims. This retrospective study uses data from traffic collision reports from 2004 and death records from the institute of ...
Edfeldt Fredrik N B - - 2011
Teaser: Based on results from 36 internal lead discovery projects we describe how fragment based screening can be used to predict druggability (ligandability) and lead discovery success.
Alexander M S - - 2011
Objective:To create the International Spinal Cord Injury (SCI) Male Sexual Function Basic Data Set within the International SCI Data Sets.Setting:An international working group.Methods:The draft of the data set was developed by an international working group consisting of members appointed by the International Spinal Cord Society (ISCoS), the American Spinal Injury ...
Krebs Christopher P - - 2011
Concerns have been expressed about the validity of self-reported data on sexual assault, as victims might be reluctant to disclose what happened to them. In this study, using an anonymous, web-based survey, a sample of 5,446 undergraduate women were asked about their experiences with physically forced sexual assault using both ...
Quentin Wilm - - 2011
To estimate the incremental costs of visual inspection with acetic acid (VIA) and cryotherapy at cervical cancer screening facilities in Ghana; to explore determinants of costs through modelling; and to estimate national scale-up and annual programme costs. Resource-use data were collected at four out of six active VIA screening centres, ...
Otte Dietmar - - 2012
Within a study of accident data from GIDAS (German In-Depth Accident Study), vulnerable road users are investigated regarding injury risk in traffic accidents. GIDAS is the largest in-depth accident study in Germany. Due to a well-defined sampling plan, representativeness with respect to the federal statistics is also guaranteed. A hierarchical ...
Czy┼╝ Marcin - - 2011
The influence of mechanical load on the extent of nervous tissue damage in the spinal cord at the time of trauma is presently incontestable. Although numerical modelling cannot fully replace physical testing, it seems to be the perfect complement to experiments in terms of the analysis of such a complex ...
Liu Margaret - - 2011
Background: Consequences of traumatic brain injury underscore the need to study high-risk groups. Few studies have investigated work-related traumatic brain injuries (WrTBIs) in the construction industry. Objective: To examine WrTBIs in Ontario for the construction industry compared to other industries. Methods: A retrospective study of individuals who sustained a WrTBI ...
Mewes Detlef - - 2011
Guards on machine tools are meant to protect persons from injuries caused by parts ejected with high kinetic energy from the machine's working zone. With respect to stationary grinding machines, Standard No. EN 13218:2002, therefore, specifies minimum wall thicknesses for guards. These values are mainly based on estimations and experience ...
Junejo Imran N - - 2011
This paper addresses recognition of human actions under view changes. We explore self-similarities of action sequences over time and observe the striking stability of such measures across views. Building upon this key observation, we develop an action descriptor that captures the structure of temporal similarities and dissimilarities within an action ...
Horsburgh Simon - - 2011
Agricultural workers experience high rates of occupational injury. There is a lack of analytic studies which provide detailed occupational exposure information to inform intervention development. A feasibility study simulating a six month prospective cohort study was designed and undertaken. The levels of farm and worker participation and retention were analysed ...
Danelson Kerry A - - 2011
Pulmonary contusion (PC) is the most common injury following blunt thoracic trauma with an associated mortality of 10% to 20%. The purpose of this study is to determine how crash parameters correlate to the volume of pulmonary contusion. The Crash Injury Research Engineering and Network (CIREN) database was queried to ...
Kowalewska Jolanta - - 2011
In humans cryoglobulinemic glomerulonephritis (CGGN) may develop in the course of systemic cryoglobulinemia (CG) and is often associated with hepatitis C virus infection. It is believed that the glomerular injury in CG results from the deposition of immune complexes, but exact sequence of events in this process is unknown. Experimental ...
Varnek Alexandre - - 2011
This chapter reviews the application of fragment descriptors at different stages of virtual screening: filtering, similarity search, and direct activity assessment using QSAR/QSPR models. Several case studies are considered. It is demonstrated that the power of fragment descriptors stems from their universality, very high computational efficiency, simplicity of interpretation, and ...
Spicer Rebecca S - - 2011
The Injury Impairment Index (III) has long been used internationally to estimate the quality-adjusted life year (QALY) losses associated with crash injuries. The III has major limitations, notably its lack of detailed validation, but it is widely used and estimates from it are regularly published. It is based on physician ...
Sadeghian Elnaz Banan - - 2011
Tongue Drive System (TDS) is a new assistive technology that enables individuals with severe disabilities such as those with spinal cord injury (SCI) to regain environmental control using their tongue motion. We have developed a new sensor signal processing (SSP) algorithm which uses four 3-axial magneto-resistive sensor outputs to accurately ...
Fu Jicheng - - 2011
Machine-learning techniques have found widespread applications in bioinformatics. Such techniques provide invaluable insight on understanding the complex biomedical mechanisms and predicting the optimal individualized intervention for patients. In our case, we are particularly interested in developing an individualized clinical guideline on wheelchair tilt and recline usage for people with spinal ...
Arliani Gustavo Gonçalves - - 2011
This study aims to establish a national methodological model for epidemiological studies on professional soccer player injuries and to describe the numerous relevant studies previously published on this topic. The risk of injury in professional soccer is high. However, previous studies of injury risk in Brazil and other countries have ...
Keall Michael D - - 2011
The authors recently undertook a study for the World Health Organization estimating the European burden of injuries that can be attributed to remediable structural hazards in the home. Such estimates are essential for motivating injury prevention efforts as they quantify potential health gains, in terms of injuries prevented, via specific ...
Manaenko Anatol - - 2011
Intracerebral hemorrhage (ICH) is the most devastating type of stroke. It is characterized by spontaneous bleeding in brain parenchyma and is associated with a high rate of morbidity and mortality. Presently, there is neither an effective therapy to increase survival after intracerebral hemorrhage nor a treatment to improve the quality ...
Kohut Lauryn K - - 2011
It is common knowledge that severe blood loss and traumatic injury can lead to a cascade of detrimental signaling events often resulting in mortality. These signaling events can also lead to sepsis and/or multiple organ dysfunction (MOD). It is critical then to investigate the causes of suppressed immune function and ...
Jacobson Misbe Elizabeth N - - 2011
Perinatal asphyxia is a leading cause of brain injury in neonates, occurring in 2-4 per 1,000 live births, and there are limited treatment options. Because of their similarity to humans, nonhuman primates are ideal for performing preclinical tests of safety and efficacy for neurotherapeutic interventions. We previously developed a primate ...
Hosking Jamie - - 2011
Although life course epidemiology is increasingly employed to conceptualize the determinants of health, the implications of this approach for strategies to reduce the burden of injuries have received little recognition to date. The authors reviewed core injury concepts and the principles of the life course approach. Based on this understanding, ...
Hutchens Michael P - - 2011
Acute Kidney Injury (AKI) is a common, highly lethal, complication of critical illness which has a high mortality and which is most frequently caused by whole-body hypoperfusion. Successful reproduction of whole-body hypoperfusion in rodent models has been fraught with difficulty. Models which employ focal ischemia have repeatedly demonstrated results which ...
Chemali Jessica J - - 2011
Burst suppression is an electroencephalogram pattern observed in states of severely reduced brain activity, such as general anesthesia, hypothermia and anoxic brain injuries. The burst suppression ratio (BSR), defined as the fraction of EEG spent in suppression per epoch, is the standard quantitative measure used to characterize burst suppression. We ...
Zhao Zhibiao - - 2011
We construct an asymptotic confidence interval for the mean of a class of nonstationary processes with constant mean and time-varying variances. Due to the large number of unknown parameters, traditional approaches based on consistent estimation of the limiting variance of sample mean through moving block or non-overlapping block methods are ...
Lienhard Stefan S Computer Vision Laboratory, ETH Zürich, 8092 Zürich, - - 2011
We describe a technique that uses tractography to visualize neural pathways in human brains by extending an existing framework that uses overlapping Gaussian tensors to model the signal. At each point on the fiber, an unscented Kalman filter is used to find the most consistent direction as a mixture of ...
Ding Ying Y Department of Biostatistics, University of Michigan, 1420 Washington Heights, Ann Arbor, MI - - 2011
In many semiparametric models that are parameterized by two types of parameters - a Euclidean parameter of interest and an infinite-dimensional nuisance parameter, the two parameters are bundled together, i.e., the nuisance parameter is an unknown function that contains the parameter of interest as part of its argument. For example, ...
Gressens Pierre P Inserm, U676, Paris, - - 2011
Sick preterm and term newborns are highly vulnerable to neural injury, and thus there has been a major search for new, safe and efficacious neuroprotective interventions in recent decades. Preclinical studies are essential to select candidate drugs for clinical trials in humans. This article focuses on 'negative' preclinical studies, i.e. ...
Heijne Janneke C M - - 2011
Repeated Chlamydia trachomatis infections after treatment are common. One reason is reinfection from untreated partners in ongoing sexual partnerships. Mathematical models that are used to predict the impact of screening on reducing chlamydia prevalence often do not incorporate reinfection and might overestimate the expected impact. We describe a pair compartmental ...
Becks L - - 2010
The evolution of sex is a classic problem in evolutionary biology. While this topic has been the focus of much theoretical work, there is a serious dearth of empirical data. A simple yet fundamental question is how sex affects the mean and variance in fitness. Despite its importance to the ...
Basak Subhash C - - 2010
This paper reports the development of quantitative structure-activity relationship (QSAR) models for a set of 170 chemicals using mathematical descriptors which can be calculated directly from molecular structure without the input of any other experimental data. The calculated descriptors include topostructural (TS), topochemical (TC), and quantum chemical (QC). Because the ...
Chen Mark I - - 2010
Models of sexually transmitted infection (STI) transmission can offer insights as to why gonorrhoea and other STIs are disproportionately concentrated in epidemiologically distinct subpopulations. We highlight two different constructs for modelling STIs by drawing on previously published work on pair and metapopulation models, and reanalysed partnership data from the National ...
Chang Tung-Ti - - 2010
Phosphodiesterase superfamily is the key regulator of 3',5'-cyclic guanosine monophosphate (cGMP) decomposition in human body. Phosphodiesterase-5 (PDE-5) inhibitors, sildenafil, vardenafil and tadalafil, are well known oral treatment for males with erectile dysfunction. To investigate the inhibitory effects of traditional Chinese medicine (TCM) compounds to PDE-5, we performed both ligand-based and ...
Borghini Alice - - 2010
Azidolysis of epoxides followed by reduction of the intermediate azido alcohols constitutes a valuable synthetic tool for the construction of beta-amino alcohols, an important chemical functionality occurring in many biologically active compounds of natural origin. However, depending on conditions under which the azidolysis is carried out, two regioisomeric products can ...
Koster M P H - - 2010
OBJECTIVE: To evaluate the modeled predictive value of three current (PAPP-A, fβ-hCG and NT) and four potential screening markers (ADAM12, thCG, PP13 and PlGF) for Down syndrome (DS), in combination with different screening settings. METHODS: All markers were measured in stored first trimester serum of 151 DS cases and 847 ...
Kompany-Zareh Mohsen - - 2010
This study is an implementation of a robust jackknife-based descriptor selection procedure assisted with Gram-Schmidt orthogonalization. Selwood data including 31 molecules and 53 descriptors was considered in this study. Both multiple linear regression (MLR) and partial least squares (PLS) regression methods were applied during the jackknife procedures, and the desired ...
Wu Baojian - - 2011
Glucuronidation is often recognized as one of the rate-determining factors that limit the bioavailability of flavonols. Hence, design and synthesis of more bioavailable flavonols would benefit from the establishment of predictive models of glucuronidation using kinetic parameters [e.g., K(m), V(max), intrinsic clearance (CL(int)) = V(max)/K(m)] derived for flavonols. This article ...
Jiang Jian Lin - - 2010
Rate constants of ozone with 39 aromatic compounds in aqueous solution were determined at 298 K. And optimized calculation was carried out at B3LYP/6-311G** level with DFT method. 10 molecular parameters obtained from calculations were selected as the descriptors to establish QSAR models for predicting the rate constants. These descriptors ...
Shao Li - - 2010
Constructing a highly predictive model and exploiting the underlying mechanism associated with a specific property of chemicals are the two main goals of quantitative structure-activity relationship analysis (QSAR). However, the latter has long been carried out as a byproduct of model construction. Here we confirmed for the first time in ...
Hsin Kun-Yi - - 2011
We present the relational database EDULISS (EDinburgh University Ligand Selection System), which stores structural, physicochemical and pharmacophoric properties of small molecules. The database comprises a collection of over 4 million commercially available compounds from 28 different suppliers. A user-friendly web-based interface for EDULISS (available at http://eduliss.bch.ed.ac.uk/) has been established providing ...
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