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Chen Yao - - 2012
Acetylcholinesterase (AChE) is considered to be one of the most important targets for the treatment of Alzheimer's disease (AD). Previously our group has reported a series of tacrine-based hybrids as potent AChE inhibitors (AChEI). To discover more novel scaffolds, molecular docking and dynamics stimulation were applied to acquire the binding ...
Lim Sookkyung - - 2012
Flagellar bundling is an important aspect of locomotion in bacteria such as Escherichia coli. To study the hydrodynamic behavior of helical flagella, we present a computational model that is based on the geometry of the bacterial flagellar filament at the micrometer scale. We consider two model flagella, each of which ...
Karimi Mohammad Taghi - - 2012
Over the years, various types of orthoses have been designed to assist subjects with spinal cord injury (SCI) to stand and walk. However, the functional performance of the orthoses has not been adequate, that is, patients experience stability problems, consume excessive energy during ambulation, and generally require assistance in donning ...
Nieto-Barajas Luis E LE Department of Statistics, - - 2012
Polya trees (PT) are random probability measures which can assign probability 1 to the set of continuous distributions for certain specifications of the hyperparameters. This feature distinguishes the PT from the popular Dirichlet process (DP) model which assigns probability 1 to the set of discrete distributions. However, the PT is ...
Serra-Añó P - - 2012
The principal aim of our study was the determination of the effectiveness of a standardized ratio, allometric scaling model and a gamma function model in normalizing the isometric torque data of spinal cord patients and healthy subjects. For this purpose we studied a sample of 21 healthy males and 23 ...
Gouttard Sylvain S Scientific Computing and Imaging Institute, University of Utah, Salt Lake City, - - 2012
The evaluation of analysis methods for diffusion tensor imaging (DTI) remains challenging due to the lack of gold standards and validation frameworks. Significant work remains in developing metrics for comparing fiber bundles generated from streamline tractography. We propose a set of volumetric and tract oriented measures for evaluating tract differences. ...
Martin Thaler - - 2012
BACKGROUND: Kuntz et al recently introduced a new system for classifying spinal deformities. This classification of spinal deformity was developed based on age-dependent deviations from the neutral upright spinal alignment. OBJECTIVE: To determine the interobserver and intraobserver reliabilities of Kuntz´s new system for classifying scoliosis. METHODS: 50 consecutive patients were ...
Medeiros R C - - 2012
Experimental trial based on the analytical study of radiographic standards of the sagittal spinal alignment in paraplegics in upright position under surface neuromuscular electrical stimulation (NMES). To evaluate changes in radiographic standards of the sagittal spinal alignment of paraplegics under three different models of NMES used to optimize the global ...
Milton Ian - - 2012
BACKGROUND AND PURPOSE: The lack of an appropriate animal model has been a limitation in studying hemorrhage from arteriovenous malformations (AVMs) in the central nervous system. METHODS: Novel mouse central nervous system AVM models were generated by conditionally deleting the activin receptor-like kinase (Alk1; Acvrl1) gene with the SM22-Cre transgene. ...
Trentzsch Heiko - - 2012
ABSTRACT: Hypothermia is considered an independent predictor of death after trauma. The aim of this study was to assess these premises based on data from the TraumaRegistry DGU® (TR-DGU) using its outcome predication tool, the Revised Injury Severity Classification (RISC) score, in comparison with three previously published regression models by ...
Haas Barbara - - 2012
Hospital administrative databases are a useful source of population-level data on injured patients; however, these databases use the International Classification of Diseases (ICD) system, which does not provide a direct means of estimating injury severity. We created and validated a crosswalk to derive Abbreviated Injury Scale (AIS) scores from injury-related ...
Karlsson A-K - - 2012
Objectives:To create an International Spinal Cord Injury (SCI) Skin and Thermoregulation Basic Data Set within the framework of the International SCI Data Sets.Setting:An international working group.Methods:The draft of the Data Set was developed by a working group comprising members appointed by the American Spinal Injury Association (ASIA), the International Spinal ...
Zhang F - - 2012
BACKGROUND AND PURPOSE:A stable stroke experimental model is highly desirable for performing longitudinal studies using MR imaging. The purpose of this study is to establish a stable focal cerebral ischemia model with a high survival rate in adult mice.MATERIALS AND METHODS:One hundred twenty adult mice were randomly divided into 10 ...
Brands Ingrid M H - - 2012
To describe a new model of the adaptation process following acquired brain injury, based on the patient's goals, the patient's abilities and the emotional response to the changes and the possible discrepancy between goals and achievements. The process of adaptation after acquired brain injury is characterized by a continuous interaction ...
Wang Hai-Xia HX College of Sciences, Anhui Science and Technology University, Fengyang 233100, Anhui Province, - - 2012
As a chronic inflammatory disease of the liver, the pathogenic mechanisms of autoimmune hepatitis (AIH) have not yet been elucidated, with prognosis and diagnosis remaining unsatisfied. Currently the only viable treatments of AIH are immunosuppressant application and liver transplantation. It is considered that lack of good animal AIH models is ...
Velani Nikunj - - 2012
Despite the possibilities offered by new approaches in design and advances in materials and manufacturing methods, few items of Personal Protective Equipment (PPE) used in sport have seen significant change for many decades. A major reason for this is the tradition and conservative attitudes associated with many sports, although the ...
Coats Brittany B Department of Mechanical Engineering, University of Utah, Salt Lake City, UT 84112, USA. - - 2012
Clinicians are charged with the significant task of distinguishing between accidental and inflicted head trauma. Oftentimes this distinction is straightforward, but many times probabilities of injuries from accidental scenarios are unknown making the differential diagnosis difficult. For example, it is unknown whether intracranial hemorrhage (IH) can occur at a location ...
Sañudo-Fontaneda Luis A - - 2012
Interlocking concrete block pavements (ICBPs) have been widely used in car parks to reduce runoff. Researches have demonstrated that clogging is the most influential factor in the reduction of the infiltration capacity of this type of permeable pavement. Nevertheless, there is no laboratory study of the infiltration performance of ICBPs ...
Pugno Nicola M - - 2012
The mechanics of fiber bundles has been widely studied in the literature, and fiber bundle models in particular have provided a wealth of useful analytical and numerical results for modeling ordinary materials. These models, however, are inadequate to treat bioinspired nanostructured materials, where hierarchy, multiscale, and complex properties play a ...
Yoo Sunyong - - 2012
Electronic Health Records (EHRs) enable the sharing of patients' medical data. Since EHRs include patients' private data, access by researchers is restricted. Therefore k-anonymity is necessary to keep patients' private data safe without damaging useful medical information. However, k-anonymity cannot prevent sensitive attribute disclosure. An alternative, l-diversity, has been proposed ...
Meese Tim S - - 2012
Contrast sensitivity improves with the area of a sine-wave grating, but why? Here we assess this phenomenon against contemporary models involving spatial summation, probability summation, uncertainty, and stochastic noise. Using a two-interval forced-choice procedure we measured contrast sensitivity for circular patches of sine-wave gratings with various diameters that were blocked ...
Liu Xuxun - - 2012
The past few years have witnessed increased interest in the potential use of wireless sensor networks (WSNs) in a wide range of applications and it has become a hot research area. Based on network structure, routing protocols in WSNs can be divided into two categories: flat routing and hierarchical or ...
Devine Darragh P - - 2012
Self-injurious behaviour is highly prevalent in neurodevelopmental disorders. Interestingly, it is not restricted to any individual diagnostic group. Rather, it is exhibited in various forms across patient groups with distinct genetic defects and classifications of disorders. This suggests that there may be shared neuropathology that confers vulnerability. Convergent evidence from ...
Długosz Mirosława M - - 2012
The mechanism of creation and pathomechanics of lateral spinal deformation is still not fully explained. Modern medical imaging techniques give scientists possibility to understand some aspects, but vast majority of those techniques is based on static trials. A motion capture system belongs to techniques which enable visualization of a spine ...
Needham R - - 2012
Optoelectronic motion capture technology is a useful tool in the quantitative dynamic assessment of the spine. In a clinical setting this may help gain a further understanding of underlining musculoskeletal pathology. It is therefore important that accurate measurements are made to allow data to be comparable across various investigations. This ...
Sharma Hari Shanker - - 2012
Spinal cord injury (SCI) is a serious clinical problem that causes lifetime disabilities to victims and inflicting huge social burden on our society. One of the main lacunae in developing potential therapeutic measures in SCI is a lack of suitable animal models that could be comparable to clinical situations. Thus, ...
Raol Yogendra H - - 2012
Epilepsy is one of the most common neurological conditions that affect people of all ages. Epilepsy is characterized by occurrence of spontaneous recurrent seizures. Currently available drugs are ineffective in controlling seizures in approximately one-third of patients with epilepsy. Moreover, these drugs are associated with adverse effects, and none of ...
Caldarelli Guido - - 2012
In this paper we analyze the bipartite network of countries and products from UN data on country production. We define the country-country and product-product projected networks and introduce a novel method of filtering information based on elements' similarity. As a result we find that country clustering reveals unexpected socio-geographic links ...
Biering-Sørensen Fin - - 2012
International Spinal Cord Injury (SCI) Data Sets include core, basic, and extended data sets. To date, 13 data sets have been published on the Web site of the International Spinal Cord Injury Society (ISCoS; www.iscos.org.uk), and several more are forthcoming. The data sets are constituted of data elements, which may ...
Terstyanszky Gabor - - 2012
Molecular docking and dynamics studies are of considerable importance in a range of disciplines including molecular biology, drug design, environmental studies, psychology, etc. Using in silico tools to support or even to substitute wet laboratory work could help better focusing the laboratory experiments resulting not only in considerable saving of ...
Kar Arindam - - 2012
In this paper a nonlinear Gabor Wavelet Transform (GWT) discriminant feature extraction approach for enhanced face recognition is proposed. Firstly, the low-energized blocks from Gabor wavelet transformed images are extracted. Secondly, the nonlinear discriminating features are analyzed and extracted from the selected low-energized blocks by the generalized Kernel Discriminative Common ...
Saakian David B - - 2012
We investigate the directed random walk on hierarchic trees. Two cases are investigated: random variables on deterministic trees with a continuous branching, and random variables on the trees constructed through the random branching process. We derive renormalization group (partial differential) equations for the branching models with binomial, Poisson, and compound ...
Feuer Ronny - - 2012
: Bacterial strains that were genetically blocked in important metabolic pathways and grown under selective conditions underwent a process of adaptive evolution: certain pathways may have been deregulated and therefore allowed for the circumvention of the given block. A block of endogenous pyruvate synthesis from glycerol was realized by a ...
Woznowski-Vu Arthur - - 2012
Purpose: The aim of the study was to determine the effect of successive repetitions of a measure of hamstring flexibility-the passive unilateral straight leg raise (SLR)-on the reliability of this measure. Method: Ten repetitions of the SLR were performed on nine healthy adults. Measures were quantified using an electromagnetic tracking ...
Nataraj Raviraj - - 2012
The purpose of this study was to determine the comparative effectiveness of feedback control systems for maintaining standing balance based on joint kinematics or total body center of mass (COM) acceleration, and assess their clinical practicality for standing neuroprostheses after spinal cord injury (SCI). In simulation, controller performance was measured ...
Tanhoffer Ricardo A - - 2012
To compare different methods of assessing energy expenditure (EE) and physical activity (PA) in people with spinal cord injury (SCI) under community-dwelling conditions. A reference standard encompassing the doubly labelled water (DLW) technique, heart rate monitoring (FLEX-HR), a multi-sensor armband (SenseWear Armband (SWA)), and two PA recall questionnaires were employed ...
Arslan Yunus Ziya - - 2012
In our previous study, we have demonstrated that analyzing the skin impedances measured along the key points of the dermatomes might be a useful supplementary technique to enhance the diagnosis of spinal cord injury (SCI), especially for unconscious and noncooperative patients. Initially, in order to distinguish between the skin impedances ...
Kremling Andreas - - 2012
Signal transduction plays a fundamental role in the understanding of cellular physiology. The bacterial phosphotransferase system (PTS) together with the PEP/pyruvate node in central metabolism represents a signaling unit that acts as a sensory element and measures the activity of the central metabolism. Pseudomonas putida possesses two PTS branches, the ...
McRae Brad H - - 2012
Landscape connectivity is crucial for many ecological processes, including dispersal, gene flow, demographic rescue, and movement in response to climate change. As a result, governmental and non-governmental organizations are focusing efforts to map and conserve areas that facilitate movement to maintain population connectivity and promote climate adaptation. In contrast, little ...
Light Matthew - - 2012
A variety of methods have been used to study inflammatory changes in the acutely injured spinal cord. Recently novel multiplex assays have been used in an attempt to overcome limitations in numbers of available targets studied in a single experiment. Other technical challenges in developing pre-clinical rodent models to investigate ...
Deng Dongdong - - 2012
Many heart anatomy models have been developed to study the electrophysiological properties of the human heart. However, none of them includes the geometry of the whole human heart. In this study, an anatomically detailed mathematical model of the human heart was firstly reconstructed from the computed tomography images. In the ...
Marshall David C - - 2012
The New Zealand (NZ) cicada fauna contains two co-distributed lineages that independently colonized the isolated continental fragment in the Miocene. One extensively studied lineage includes 90% of the extant species (Kikihia + Maoricicada + Rhodopsalta; ca 51 spp.), while the other contains just four extant species (Amphipsalta - 3 spp. + Notopsalta - 1 ...
He Wei - - 2012
A new method based on discrete particle swarm optimization (dPSO) algorithm is proposed to solve the branch-cut phase unwrapping problem of MRI data. In this method, the optimal order of matching the positive residues with the negative residues is first identified by the dPSO algorithm, then the branch cuts are ...
Guimerà Roger - - 2012
With ever-increasing available data, predicting individuals' preferences and helping them locate the most relevant information has become a pressing need. Understanding and predicting preferences is also important from a fundamental point of view, as part of what has been called a "new" computational social science. Here, we propose a novel ...
Joucla Sébastien - - 2012
Electrical stimulation of the central nervous system has been widely used for decades for either fundamental research purposes or clinical treatment applications. Yet, very little is known regarding the spatial extent of an electrical stimulation. If pioneering experimental studies reported that activation threshold currents (TCs) increase with the square of ...
Coakley Timothy A - - 2012
The current leading cause of death to troops in Operations Enduring Freedom results from improvised explosive devices. The need for accurate models of combat trauma in research is an ever present challenge and crucial to our efforts to save the lives of our injured troops. Current swine models of groin ...
Gittoes Marianne M - - 2012
Gymnasts are exposed to a high incidence of impact landings due to the execution of repeated dismount performances. Biomechanical research can help inform recent discussions surrounding a proposed rule change in potentially injurious gymnastic dismounting. The review examines existing understanding of the mechanisms influencing the impact loads incurred in gymnastic-style ...
Kück Patrick - - 2012
[This corrects the article on p. e36593 in vol. 7.].
Günther René R Department of Neurology, University Medicine Göttingen, Göttingen, - - 2012
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder resulting in progressive degeneration of motoneurons. Peak of onset is around 60 years for the sporadic disease and around 50 years for the familial disease. Due to its progressive course, 50% of the patients die within 30 months of symptom onset. ...
Gluhovsky I - - 2012
Keerthi and Shevade (2007) proposed an efficient algorithm for constructing an approximate least angle regression least absolute shrinkage and selection operator solution path for logistic regression as a function of the regularization parameter. In this brief, their approach is extended to multinomial regression. We show that a brute-force approach leads ...
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