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Aaltonen T - - 2012
The decays B_{s}^{0}→D_{s}^{(*)+}D_{s}^{(*)-} are reconstructed in a data sample corresponding to an integrated luminosity of 6.8  fb^{-1} collected by the CDF II detector at the Tevatron pp[over ¯] collider. All decay modes are observed with a significance of more than 10σ, and we measure the B_{s}^{0} production rate times B_{s}^{0}→D_{s}^{(*)+}D_{s}^{(*)-} branching ...
Zurita Mercedes - - 2012
The regenerative medicine techniques that are beginning to be applied to the nervous system have led to increased hope in the treatment of diseases that have been considered incurable and that require experimental models on which to test new therapeutic strategies. We present our experience with adult pigs (minipigs) that ...
Seshadhri C - - 2012
Community structure plays a significant role in the analysis of social networks and similar graphs, yet this structure is little understood and not well captured by most models. We formally define a community to be a subgraph that is internally highly connected and has no deeper substructure. We use tools ...
Peixoto Tiago P - - 2012
Stochastic blockmodels are generative network models where the vertices are separated into discrete groups, and the probability of an edge existing between two vertices is determined solely by their group membership. In this paper, we derive expressions for the entropy of stochastic blockmodel ensembles. We consider several ensemble variants, including ...
Noonan Vanessa K - - 2012
Background: Despite decades of research, there are no national estimates of the incidence or prevalence of spinal cord injury (SCI) in Canada. Our objective was to utilize the best available data to estimate the incidence and prevalence of traumatic SCI (TSCI) and non-traumatic SCI (NTSCI) in Canada for 2010. Methods: ...
Weisse B - - 2012
The knowledge of spinal kinematics is of paramount importance for many aspects of clinical application (i.e. diagnosis, treatment and surgical intervention) and for the development of new spinal implants. The aim of this study was to determine the translational and rotational stiffnesses of a functional spinal unit (FSU) L4-L5 using ...
Tan Sidhartha - - 2012
Nanomedicine treatment postnatally in an inflammatory model of cerebral palsy ameliorates motor deficits.
Wong Johnny - - 2012
BACKGROUND:: Post-traumatic syringomyelia affects approximately 28% of spinal cord injury patients and current treatments are often ineffective. The pathogenesis of this condition remains poorly understood. Previous reports have focused on pathways and mechanisms of fluid inflow; however, disturbances of fluid outflow mechanisms and pathways may be important in syrinx formation ...
Corbett Elaine A - - 2012
Neuroprosthetic devices promise to allow paralyzed patients to perform the necessary functions of everyday life. However, to allow patients to use such tools it is necessary to decode their intent from neural signals such as electromyograms (EMGs). Because these signals are noisy, state of the art decoders integrate information over ...
Lacquaniti Francesco - - 2012
Neural control of locomotion in human adults involves the generation of a small set of basic patterned commands directed to the leg muscles. The commands are generated sequentially in time during each step by neural networks located in the spinal cord, called Central Pattern Generators. This review outlines recent advances ...
Nout Yvette S - - 2012
Primates are an important and unique animal resource. We have developed a nonhuman primate model of spinal cord injury (SCI) to expand our knowledge of normal primate motor function, to assess the impact of disease and injury on sensory and motor function, and to test candidate therapies before they are ...
Charlifue S - - 2012
Study design:Survey of expert opinion, feedback, and development of final consensus.Objective:Present the background, purpose, development process and results for the International Spinal Cord Injury (SCI) Quality of Life (QoL) Basic Data Set.Setting:International.Methods:A committee of experts was established to select and define data elements to be included in an International SCI ...
Chen Yao - - 2012
Acetylcholinesterase (AChE) is considered to be one of the most important targets for the treatment of Alzheimer's disease (AD). Previously our group has reported a series of tacrine-based hybrids as potent AChE inhibitors (AChEI). To discover more novel scaffolds, molecular docking and dynamics stimulation were applied to acquire the binding ...
Lim Sookkyung - - 2012
Flagellar bundling is an important aspect of locomotion in bacteria such as Escherichia coli. To study the hydrodynamic behavior of helical flagella, we present a computational model that is based on the geometry of the bacterial flagellar filament at the micrometer scale. We consider two model flagella, each of which ...
Karimi Mohammad Taghi - - 2012
Over the years, various types of orthoses have been designed to assist subjects with spinal cord injury (SCI) to stand and walk. However, the functional performance of the orthoses has not been adequate, that is, patients experience stability problems, consume excessive energy during ambulation, and generally require assistance in donning ...
Nieto-Barajas Luis E LE Department of Statistics, - - 2012
Polya trees (PT) are random probability measures which can assign probability 1 to the set of continuous distributions for certain specifications of the hyperparameters. This feature distinguishes the PT from the popular Dirichlet process (DP) model which assigns probability 1 to the set of discrete distributions. However, the PT is ...
Serra-Añó P - - 2012
The principal aim of our study was the determination of the effectiveness of a standardized ratio, allometric scaling model and a gamma function model in normalizing the isometric torque data of spinal cord patients and healthy subjects. For this purpose we studied a sample of 21 healthy males and 23 ...
Gouttard Sylvain S Scientific Computing and Imaging Institute, University of Utah, Salt Lake City, - - 2012
The evaluation of analysis methods for diffusion tensor imaging (DTI) remains challenging due to the lack of gold standards and validation frameworks. Significant work remains in developing metrics for comparing fiber bundles generated from streamline tractography. We propose a set of volumetric and tract oriented measures for evaluating tract differences. ...
Martin Thaler - - 2012
BACKGROUND: Kuntz et al recently introduced a new system for classifying spinal deformities. This classification of spinal deformity was developed based on age-dependent deviations from the neutral upright spinal alignment. OBJECTIVE: To determine the interobserver and intraobserver reliabilities of Kuntz´s new system for classifying scoliosis. METHODS: 50 consecutive patients were ...
Medeiros R C - - 2012
Experimental trial based on the analytical study of radiographic standards of the sagittal spinal alignment in paraplegics in upright position under surface neuromuscular electrical stimulation (NMES). To evaluate changes in radiographic standards of the sagittal spinal alignment of paraplegics under three different models of NMES used to optimize the global ...
Milton Ian - - 2012
BACKGROUND AND PURPOSE: The lack of an appropriate animal model has been a limitation in studying hemorrhage from arteriovenous malformations (AVMs) in the central nervous system. METHODS: Novel mouse central nervous system AVM models were generated by conditionally deleting the activin receptor-like kinase (Alk1; Acvrl1) gene with the SM22-Cre transgene. ...
Trentzsch Heiko - - 2012
ABSTRACT: Hypothermia is considered an independent predictor of death after trauma. The aim of this study was to assess these premises based on data from the TraumaRegistry DGU® (TR-DGU) using its outcome predication tool, the Revised Injury Severity Classification (RISC) score, in comparison with three previously published regression models by ...
Haas Barbara - - 2012
Hospital administrative databases are a useful source of population-level data on injured patients; however, these databases use the International Classification of Diseases (ICD) system, which does not provide a direct means of estimating injury severity. We created and validated a crosswalk to derive Abbreviated Injury Scale (AIS) scores from injury-related ...
Zhu Hong-Ming HM Division of Stem Cell and Tissue Engineering, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, - - 2012
Traditional Herbal Medicine (THM) has many advantages that make it a promising choice for the treatment of ischemic heart disease (IHD). To study the mechanism of IHDs or pharmacological actions of THM, many hypoxia-induced cardiomyocyte injury models have been established. Radix Salvia miltorrhiza (Danshen) was used as a representative of ...
Karlsson A-K - - 2012
Objectives:To create an International Spinal Cord Injury (SCI) Skin and Thermoregulation Basic Data Set within the framework of the International SCI Data Sets.Setting:An international working group.Methods:The draft of the Data Set was developed by a working group comprising members appointed by the American Spinal Injury Association (ASIA), the International Spinal ...
Zhang F - - 2012
BACKGROUND AND PURPOSE:A stable stroke experimental model is highly desirable for performing longitudinal studies using MR imaging. The purpose of this study is to establish a stable focal cerebral ischemia model with a high survival rate in adult mice.MATERIALS AND METHODS:One hundred twenty adult mice were randomly divided into 10 ...
Brands Ingrid M H - - 2012
To describe a new model of the adaptation process following acquired brain injury, based on the patient's goals, the patient's abilities and the emotional response to the changes and the possible discrepancy between goals and achievements. The process of adaptation after acquired brain injury is characterized by a continuous interaction ...
Wang Hai-Xia HX College of Sciences, Anhui Science and Technology University, Fengyang 233100, Anhui Province, - - 2012
As a chronic inflammatory disease of the liver, the pathogenic mechanisms of autoimmune hepatitis (AIH) have not yet been elucidated, with prognosis and diagnosis remaining unsatisfied. Currently the only viable treatments of AIH are immunosuppressant application and liver transplantation. It is considered that lack of good animal AIH models is ...
Velani Nikunj - - 2012
Despite the possibilities offered by new approaches in design and advances in materials and manufacturing methods, few items of Personal Protective Equipment (PPE) used in sport have seen significant change for many decades. A major reason for this is the tradition and conservative attitudes associated with many sports, although the ...
Coats Brittany B Department of Mechanical Engineering, University of Utah, Salt Lake City, UT 84112, USA. - - 2012
Clinicians are charged with the significant task of distinguishing between accidental and inflicted head trauma. Oftentimes this distinction is straightforward, but many times probabilities of injuries from accidental scenarios are unknown making the differential diagnosis difficult. For example, it is unknown whether intracranial hemorrhage (IH) can occur at a location ...
Sañudo-Fontaneda Luis A - - 2012
Interlocking concrete block pavements (ICBPs) have been widely used in car parks to reduce runoff. Researches have demonstrated that clogging is the most influential factor in the reduction of the infiltration capacity of this type of permeable pavement. Nevertheless, there is no laboratory study of the infiltration performance of ICBPs ...
Pugno Nicola M - - 2012
The mechanics of fiber bundles has been widely studied in the literature, and fiber bundle models in particular have provided a wealth of useful analytical and numerical results for modeling ordinary materials. These models, however, are inadequate to treat bioinspired nanostructured materials, where hierarchy, multiscale, and complex properties play a ...
Yoo Sunyong - - 2012
Electronic Health Records (EHRs) enable the sharing of patients' medical data. Since EHRs include patients' private data, access by researchers is restricted. Therefore k-anonymity is necessary to keep patients' private data safe without damaging useful medical information. However, k-anonymity cannot prevent sensitive attribute disclosure. An alternative, l-diversity, has been proposed ...
Meese Tim S - - 2012
Contrast sensitivity improves with the area of a sine-wave grating, but why? Here we assess this phenomenon against contemporary models involving spatial summation, probability summation, uncertainty, and stochastic noise. Using a two-interval forced-choice procedure we measured contrast sensitivity for circular patches of sine-wave gratings with various diameters that were blocked ...
Liu Xuxun - - 2012
The past few years have witnessed increased interest in the potential use of wireless sensor networks (WSNs) in a wide range of applications and it has become a hot research area. Based on network structure, routing protocols in WSNs can be divided into two categories: flat routing and hierarchical or ...
Devine Darragh P - - 2012
Self-injurious behaviour is highly prevalent in neurodevelopmental disorders. Interestingly, it is not restricted to any individual diagnostic group. Rather, it is exhibited in various forms across patient groups with distinct genetic defects and classifications of disorders. This suggests that there may be shared neuropathology that confers vulnerability. Convergent evidence from ...
Długosz Mirosława M - - 2012
The mechanism of creation and pathomechanics of lateral spinal deformation is still not fully explained. Modern medical imaging techniques give scientists possibility to understand some aspects, but vast majority of those techniques is based on static trials. A motion capture system belongs to techniques which enable visualization of a spine ...
Needham R - - 2012
Optoelectronic motion capture technology is a useful tool in the quantitative dynamic assessment of the spine. In a clinical setting this may help gain a further understanding of underlining musculoskeletal pathology. It is therefore important that accurate measurements are made to allow data to be comparable across various investigations. This ...
Sharma Hari Shanker - - 2012
Spinal cord injury (SCI) is a serious clinical problem that causes lifetime disabilities to victims and inflicting huge social burden on our society. One of the main lacunae in developing potential therapeutic measures in SCI is a lack of suitable animal models that could be comparable to clinical situations. Thus, ...
Raol Yogendra H - - 2012
Epilepsy is one of the most common neurological conditions that affect people of all ages. Epilepsy is characterized by occurrence of spontaneous recurrent seizures. Currently available drugs are ineffective in controlling seizures in approximately one-third of patients with epilepsy. Moreover, these drugs are associated with adverse effects, and none of ...
Caldarelli Guido - - 2012
In this paper we analyze the bipartite network of countries and products from UN data on country production. We define the country-country and product-product projected networks and introduce a novel method of filtering information based on elements' similarity. As a result we find that country clustering reveals unexpected socio-geographic links ...
Biering-Sørensen Fin - - 2012
International Spinal Cord Injury (SCI) Data Sets include core, basic, and extended data sets. To date, 13 data sets have been published on the Web site of the International Spinal Cord Injury Society (ISCoS; www.iscos.org.uk), and several more are forthcoming. The data sets are constituted of data elements, which may ...
Terstyanszky Gabor - - 2012
Molecular docking and dynamics studies are of considerable importance in a range of disciplines including molecular biology, drug design, environmental studies, psychology, etc. Using in silico tools to support or even to substitute wet laboratory work could help better focusing the laboratory experiments resulting not only in considerable saving of ...
Kar Arindam - - 2012
In this paper a nonlinear Gabor Wavelet Transform (GWT) discriminant feature extraction approach for enhanced face recognition is proposed. Firstly, the low-energized blocks from Gabor wavelet transformed images are extracted. Secondly, the nonlinear discriminating features are analyzed and extracted from the selected low-energized blocks by the generalized Kernel Discriminative Common ...
Saakian David B - - 2012
We investigate the directed random walk on hierarchic trees. Two cases are investigated: random variables on deterministic trees with a continuous branching, and random variables on the trees constructed through the random branching process. We derive renormalization group (partial differential) equations for the branching models with binomial, Poisson, and compound ...
Feuer Ronny - - 2012
: Bacterial strains that were genetically blocked in important metabolic pathways and grown under selective conditions underwent a process of adaptive evolution: certain pathways may have been deregulated and therefore allowed for the circumvention of the given block. A block of endogenous pyruvate synthesis from glycerol was realized by a ...
Nataraj Raviraj - - 2012
The purpose of this study was to determine the comparative effectiveness of feedback control systems for maintaining standing balance based on joint kinematics or total body center of mass (COM) acceleration, and assess their clinical practicality for standing neuroprostheses after spinal cord injury (SCI). In simulation, controller performance was measured ...
Tanhoffer Ricardo A - - 2012
To compare different methods of assessing energy expenditure (EE) and physical activity (PA) in people with spinal cord injury (SCI) under community-dwelling conditions. A reference standard encompassing the doubly labelled water (DLW) technique, heart rate monitoring (FLEX-HR), a multi-sensor armband (SenseWear Armband (SWA)), and two PA recall questionnaires were employed ...
Arslan Yunus Ziya - - 2012
In our previous study, we have demonstrated that analyzing the skin impedances measured along the key points of the dermatomes might be a useful supplementary technique to enhance the diagnosis of spinal cord injury (SCI), especially for unconscious and noncooperative patients. Initially, in order to distinguish between the skin impedances ...
Kremling Andreas - - 2012
Signal transduction plays a fundamental role in the understanding of cellular physiology. The bacterial phosphotransferase system (PTS) together with the PEP/pyruvate node in central metabolism represents a signaling unit that acts as a sensory element and measures the activity of the central metabolism. Pseudomonas putida possesses two PTS branches, the ...
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