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Pham Jimmy J Arizona College of Osteopathic Medicine, Midwestern University , Glendale, AZ , USA - - 2014
Abstract The potent anti-proliferative and pro-apoptotic actions of tocotrienols (T3) against cancer, but not normal tissues, have been hampered by their limited systemic bioavailabilty. Recent expansive development of diverse nanoemulsion (NE) vehicles emphasized their vast potential to improve the effective dosing of different clinical and experimental drugs of lipophilic nature, ...
Steinway Steven Nathaniel SN Department of Medicine, Penn State College of Medicine - - 2014
Epithelial-to-mesenchymal transition (EMT) is a developmental process hijacked by cancer cells to leave the primary tumor site, invade surrounding tissue, and establish distant metastases. A hallmark of EMT is the loss of E-cadherin expression, and one major signal for the induction of EMT is transforming growth factor beta (TGFβ), which ...
Liu Xiao - - 2014
Monocular multiple-object tracking is a fundamental yet under-addressed computer vision problem. In this paper, we propose a novel learning framework for tracking multiple objects by detection. First, instead of heuristically defining a tracking algorithm, we learn that a discriminative structure prediction model from labeled video data captures the interdependence of ...
Vidyarthi Navneet N Department of Supply Chain and Business Technology Management, John Molson School of Business, Concordia University, 1455 de Maisonneuve Blvd. West, Montreal, QC, H3G 1M8, Canada, - - 2014
Preventive healthcare (PH) programs and services aim at reducing the likelihood and severity of potentially life-threatening illness by early detection and prevention. The effectiveness of these programs depends on the participation level and the accessibility of the users to the facilities providing the services. Factors that impact the accessibility include ...
Wang Junjie J 1] School of Traffic and Transportation Engineering, Central South University, Changsha, Hunan, 410000, P.R. China - - 2014
Using road GIS (geographical information systems) data and travel demand data for two U.S. urban areas, the dynamical driver sources of each road segment were located. A method to target road clusters closely related to urban traffic congestion was then developed to improve road network efficiency. The targeted road clusters ...
Carvalho Rui R School of Mathematical Sciences, Queen Mary University of London, London, United - - 2014
Human conflict, geopolitical crises, terrorist attacks, and natural disasters can turn large parts of energy distribution networks offline. Europe's current gas supply network is largely dependent on deliveries from Russia and North Africa, creating vulnerabilities to social and political instabilities. During crises, less delivery may mean greater congestion, as the ...
Lee Ga-Won GW Department of Computer Engineering, Kyung Hee University, 1732 Deogyeong-daero, Seochon-dong, Giheung-gu, Yongin-si, Gyeonggi-do 446-701, Korea. - - 2014
Information technology (IT) is pushing ahead with drastic reforms of modern life for improvement of human welfare. Objects constitute "Information Networks" through smart, self-regulated information gathering that also recognizes and controls current information states in Wireless Sensor Networks (WSNs). Information observed from sensor networks in real-time is used to increase ...
Louf Rémi R Institut de Physique Théorique, CEA, CNRS-URA 2306, F-91191, Gif-sur-Yvette, - - 2014
The recent availability of data for cities has allowed scientists to exhibit scalings which present themselves in the form of a power-law dependence on population of various socio-economical and structural indicators. We propose here a stochastic theory of urban growth which accounts for some of the observed scalings and we ...
Lee Tsair-Fwu TF Medical Physics and Informatics Laboratory of Electronics Engineering, National Kaohsiung University of Applied Sciences, Kaohsiung, Taiwan, - - 2014
To predict the incidence of moderate-to-severe patient-reported xerostomia among head and neck squamous cell carcinoma (HNSCC) and nasopharyngeal carcinoma (NPC) patients treated with intensity-modulated radiotherapy (IMRT). Multivariable normal tissue complication probability (NTCP) models were developed by using quality of life questionnaire datasets from 152 patients with HNSCC and 84 patients ...
Cassese Alberto A Department of Statistics, Rice University, Houston, TX, USA. ; Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX, - - 2014
We consider a Bayesian hierarchical model for the integration of gene expression levels with comparative genomic hybridization (CGH) array measurements collected on the same subjects. The approach defines a measurement error model that relates the gene expression levels to latent copy number states. In turn, the latent states are related ...
Louf Rémi - - 2013
Empirical evidence suggests that most urban systems experience a transition from a monocentric to a polycentric organization as they grow and expand. We propose here a stochastic, out-of-equilibrium model of the city, which explains the appearance of subcenters as an effect of traffic congestion. We show that congestion triggers the ...
Lainscsek Claudia - - 2013
Time series analysis with nonlinear delay differential equations (DDEs) reveals nonlinear as well as spectral properties of the underlying dynamical system. Here, global DDE models were used to analyze 5 min data segments of electrocardiographic (ECG) recordings in order to capture distinguishing features for different heart conditions such as normal ...
Bachmat Eitan - - 2013
The problem of finding an optimal back-to-front airplane boarding policy is explored, using a mathematical model that is related to the 1+1 polynuclear growth model with concave boundary conditions and to causal sets in gravity. We study all airplane configurations and boarding group sizes. Optimal boarding policies for various airplane ...
Galatioto Fabio - - 2013
This paper describes an in-depth analysis to investigate the huge variation in the measured roadside air-pollutant concentrations of carbon monoxide and nitrogen dioxide in terms of the traffic flow levels, the orientation of the street to the prevailing wind, the wind speed, temperature and barometric pressure. The work has attempted ...
Mee Michael T - - 2012
Microbial ecosystems play an important role in nature. Engineering these systems for industrial, medical, or biotechnological purposes are important pursuits for synthetic biologists and biological engineers moving forward. Here we provide a review of recent progress in engineering natural and synthetic microbial ecosystems. We highlight important forward engineering design principles, ...
Habib Michel M Université Paris Diderot-Paris 7, LIAFA, Case 7014, 75205 Paris Cedex 13, France. - - 2012
For a given set L of species and a set T of triplets on L, we seek to construct a phylogenetic network which is consistent with T i.e. which represents all triplets of T. The level of a network is defined as the maximum number of hybrid vertices in its ...
Sambo Francesco - - 2012
Reverse engineering is the problem of inferring the structure of a network of interactions between biological variables from a set of observations. In this paper, we propose an optimization algorithm, called MORE, for the reverse engineering of biological networks from time series data. The model inferred by MORE is a ...
Scott Paul J - - 2012
The aim of precision engineering is the accurate control of geometry. For this reason, mathematics has a long association with precision engineering: from the calculation and correction of angular scales used in surveying and astronomical instrumentation to statistical averaging techniques used to increase precision. This study illustrates the enabling role ...
Mohammed Yassene - - 2012
Data analysis in mass spectrometry-based proteomics struggles to keep pace with the advances in instrumentation and the increasing rate of data acquisition. Analyzing this data involves multiple steps requiring diverse software, using different algorithms and data formats. Speed and performance of the mass spectral search engines are continuously improving, although ...
Marschall Tobias - - 2012
We present a comprehensive review on probabilistic arithmetic automata (PAAs), a general model to describe chains of operations whose operands depend on chance, along with two algorithms to numerically compute the distribution of the results of such probabilistic calculations. PAAs provide a unifying framework to approach many problems arising in ...
Amotchkina Tatiana V - - 2012
Determination of actual parameters of manufactured optical coatings (reverse engineering of optical coatings) provides feedback to the design-production chain and thus plays an important role in raising the quality of optical coatings production. In this paper, the reliability of reverse engineering results obtained using different types of experimental data is ...
Nawroth Janna C JC Division of Biology, California Institute of Technology, Pasadena, California, - - 2012
Reverse engineering of biological form and function requires hierarchical design over several orders of space and time. Recent advances in the mechanistic understanding of biosynthetic compound materials, computer-aided design approaches in molecular synthetic biology 4,5 and traditional soft robotics, and increasing aptitude in generating structural and chemical micro environments that ...
Haj-Ali Rami R School of Mechanical Engineering, Faculty of Engineering, Tel Aviv University, Tel Aviv, Israel. - - 2012
The complex three-dimensional (3D) geometry of the native tricuspid aortic valve (AV) is represented by select parametric curves allowing for a general construction and representation of the 3D-AV structure including the cusps, commissures and sinuses. The proposed general mathematical description is performed by using three independent parametric curves, two for ...
Rizvi Mohd S - - 2012
Electrospun micro-/nano-fibrous biomaterials are widely used as extracellular matrix substitutes in tissue engineering applications because of their structural as well as mechanical properties. To explore the influence of microstructure on mechanical behavior of the fibrous materials a mathematical model of the fiber system has been developed. The model describes the ...
Chandrawati Rona - - 2012
Liposomes and polymersomes have attracted significant attention and have emerged as versatile materials for therapeutic delivery and in the design of artificial cells and organelles. Through the judicious choice of building blocks, these synthetic carriers can be readily engineered with tailored interfacial properties, offering new possibilities for the design of ...
Løset Geir Ge - - 2012
Phage display technology has evolved to become an extremely versatile and powerful platform for protein engineering. The robustness of the phage particle, its ease of handling and its ability to tolerate a range of different capsid fusions are key features that explain the dominance of phage display in combinatorial engineering. ...
Danielson M E ME Department of Epidemiology, University of Pittsburgh, 130 DeSoto St., Pittsburgh, PA 15261, USA. - - 2013
The study goal was to compare simple two-dimensional (2D) analyses of bone strength using dual energy x-ray absorptiometry (DXA) data to more sophisticated three-dimensional (3D) finite element analyses using quantitative computed tomography (QCT) data. DXA- and QCT-derived femoral neck geometry, simple strength indices, and strength estimates were well correlated. Simple ...
Klabunde Thomas - - 2012
The three-dimensional (3D) superimposition of molecules of one biological target reflecting their relative bioactive orientation is key for several ligand-based drug design studies (e.g. QSAR studies, pharmacophore modeling). However, with the lack of sufficient ligand-protein complex structures, an experimental alignment is difficult or often impossible to obtain. Several computational 3D ...
Cervantes Emilio - - 2012
Seed shape in the model legumes Lotus japonicus and Medicago truncatula is described. Based in previous work with Arabidopsis, the outline of the longitudinal sections of seeds is compared with a cardioid curve. L. japonicus seeds adjust well to an unmodified cardioid, whereas accurate adjustment in M. truncatula is obtained ...
Oh Ji-Youn - - 2012
ABSTRACT: Recently, surgical-orthodontic treatment without preoperative orthodontic treatment (known as the surgery-first approach or SFA) has been proposed to improve facial aesthetics from the beginning of treatment, to shorten the entire treatment period, and to take advantage of the regional accelerated phenomenon for orthodontic tooth movement. The SFA concept involves ...
Qian Yunzhu - - 2012
BACKGROUND/AIM: This paper explored the correlation between cuspal inclination and tooth cracked syndrome by measuring and reconstructing the cuspal inclinations of cracked maxillary first molars through three-dimensional (3D) finite element analysis (FEA). MATERIAL AND METHODS: The cuspal inclinations of 11 maxillary left first molars with cracked tooth syndrome and 22 ...
Kim Ji Heui - - 2012
Controlled biodegradability of biomaterials is very important because different functionality and durability are required for various purposes and for specific tissues and organs. From this point of view, silk-based biomaterials have poor usability because of uncontrollable degradability, even though silk fibroin (SF) is highly biocompatible and a number of studies ...
Hesselberg Thomas - - 2012
Detailed information on web geometry and the material properties of the various silks used elucidates the function of the web's different structures. In this study we investigated the non-sticky spiral in Nephila edulis webs, which in this species is not removed during web-building. This permanent non-sticky spiral shows several modifications ...
Li Jianying - - 2012
OBJECTIVES: The aim of this study was to numerically evaluate the effects of filler contents and resin properties on the material properties of dental composites utilizing realistic 3D micromechanical finite element models. METHODS: 3D micromechanical finite element models of dental composites containing irregular fillers with non-uniform sizes were created based ...
Yoo Dongjin - - 2012
Advanced additive manufacture (AM) techniques are now being developed to fabricate scaffolds with controlled internal pore architectures in the field of tissue engineering. In general, these techniques use a hybrid method which combines computer-aided design (CAD) with computer-aided manufacturing (CAM) tools to design and fabricate complicated three-dimensional (3D) scaffold models. ...
Wang Fuyang - - 2012
Eighteen phenol derivatives were optimized with density function theory (DFT) and comparative molecular similarity indices analysis (CoMSIA) respectively. Corresponding 2D and 3D descriptors were obtained to establish QSBR models. The biodegradation of them is mainly related to α and S (ө) according to the 2D QSBR, and influenced by the ...
Laroo Christopher A - - 2012
Exhaust emissions of seventeen 2,3,7,8-substituted polychlorinated dibenzo-p-dioxin/furan (PCDD/F) congeners, tetra-octa PCDD/F homologues, 12 WHO 2005 polychlorinated biphenyl (PCB) congeners, mono-nona chlorinated biphenyl homologues, and 19 polycyclic aromatic hydrocarbons (PAHs) from three legacy diesel engines were investigated. The three engines tested were a 1985 model year GM 6.2J-series engine, a 1987 ...
Castro Nathan J - - 2012
This review provides a brief synopsis of the anatomy and physiology of the osteochondral interface, scaffold-based and non-scaffold based approaches for engineering both tissues independently as well as recent developments in the manufacture of gradient constructs. Novel manufacturing techniques and nanotechnology will be discussed with potential application in osteochondral interfacial ...
Amadi Hippolite O - - 2012
Analysis of the function of glenohumeral ligaments (GHLs) during physical joint manipulations is hindered by an inability to adequately image these tissues during the movements. This restricts functional biomechanics studies only to the manoeuvres that may be replicated cadaverically. There is, however, a clinical imperative to be able to investigate ...
Rizik David G - - 2012
The everolimus-eluting XIENCE side-branch access (SBA) stent has been the focus of numerous recent publications. Most of the information available on this device comes from the preclinical studies performed in ovine models as well as perfused synthetic heart models. It has now become available in Europe as part of a ...
Gajewicz Agnieszka - - 2012
Nanotechnology that develops novel materials at size of 100nm or less has become one of the most promising areas of human endeavor. Because of their intrinsic properties, nanoparticles are commonly employed in electronics, photovoltaic, catalysis, environmental and space engineering, cosmetic industry and - finally - in medicine and pharmacy. In ...
Ragno Rino - - 2012
Since it first appearance in 1988 3-D QSAR has proved its potential in the field of drug design and activity prediction. Although thousands of citations now exist in 3-D QSAR its development was rather slow with the majority of new 3-D QSAR applications just extensions of CoMFA. An alternative way ...
Chen Luyun L Departments of Mechanical Engineering, University of Michigan, Ann Arbor, MI, USA. - - 2013
The cardinal ligament (CL) and deep uterosacral ligament (US) play a critical role in utero-vaginal support. This study aims to quantify their geometrical relationships in living women using a MRI-based 3D technique. The angles between ligaments, the ligaments length and curvature were assessed on 3D models constructed from twenty MRIs ...
Schneider Matthias - - 2012
We present an approach to generate 3-D arterial tree models based on physiological principles while at the same time certain morphological properties are enforced at construction time. The driving force of the construction is a simplified angiogenesis model incorporating case-specific information about the metabolic demand within the considered domain. The ...
Minsart A-F - - 2012
Objectives This study aimed to compare three-dimensional (3D) power Doppler sonographic characteristics of fibroids to histopathologic parameters. Methods Sonographic evaluation of 73 fibroids before myomectomy or hysterectomy was performed. For each fibroid, the total fibroid volume, a spherical belt of 3 mm and a 1cm(3) spherical volume sample were captured. ...
Cheng Allen - - 2012
Over the past decade, synthetic biology has emerged as an engineering discipline for biological systems. Compared with other substrates, biology poses a unique set of engineering challenges resulting from an incomplete understanding of natural biological systems and tools for manipulating them. To address these challenges, synthetic biology is advancing from ...
- - 2012
Cover: A model of conditioning of MSCs by "microenvironmental niches" in vitro. Please see article in this issue by Prockop and Oh, pages 1460-1469.
Li Haojie - - 2012
This paper aims to identify the impacts of the London congestion charge on road casualties within the central London charging zone. It develops a full difference-in-difference (DID) model that is integrated with generalized linear models, such as Poisson and Negative Binomial regression models. Covariates are included in the model to ...
Kang Hyun-Wook - - 2012
Tissue engineering, which is the study of generating biological substitutes to restore or replace tissues or organs, has the potential to meet current needs for organ transplantation and medical interventions. Various approaches have been attempted to apply three-dimensional (3D) solid freeform fabrication technologies to tissue engineering for scaffold fabrication. Among ...
Maes F - - 2012
Fluid mechanical stimuli are known to upregulate cell differentiation and matrix formation. Since wall shear stress plays an important role various studies tried to estimate the scaffold fluid dynamic environment. However, because of the geometrical complexity, nearly all studies created their CFD model based on a submodel of the entire ...
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