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Averina Viktoria A VA Department of Mathematics, University of Minnesota, Minneapolis, MN, - - 2014
Salt-sensitivity of arterial pressure (salt-sensitive hypertension) is a serious global health issue. The causes of salt-sensitive hypertension are extremely complex and mathematical models can elucidate potential mechanisms that are experimentally inaccessible. Until recently, the only mathematical model for long-term control of arterial pressure was the model of Guyton and Coleman; ...
Don-Wauchope Andrew C AC Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, - - 2014
The aim of this study was to determine whether measurement of natriuretic peptides independently adds incremental predictive value for mortality and morbidity in patients with chronic stable heart failure (CSHF). We electronically searched Medline(®), Embase™, AMED, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, and CINAHL from 1989 ...
Howard David H DH From the Department of Health Policy and Management, the Department of Economics, and the Winship Cancer Center, Emory University, - - 2014
Many insurers participating in the new insurance exchanges are controlling costs by offering plans with narrow provider networks. Proposed regulations would promote network adequacy, but a pro-provider stance may not be inherently pro-consumer or even pro-patient.
Azizi Ali A Graduate Faculty of Environment, University of Tehran, Tehran, - - 2014
Wind energy is a renewable energy resource that has increased in usage in most countries. Site selection for the establishment of large wind turbines, called wind farms, like any other engineering project, requires basic information and careful planning. This study assessed the possibility of establishing wind farms in Ardabil province ...
Wen Bo B BGI-Shenzhen, Shenzhen, 518083, - - 2014
Quantitative proteomics technology based on isobaric tags is playing an important role in proteomic investigation. In this paper, we present automated software, named IQuant, which integrates a post-processing tool of protein identification and advanced statistical algorithms to process the MS/MS signals generated from the peptides labeled by isobaric tags and ...
Santaguida Pasqualina L PL Department of Clinical Epidemiology and Biostatistics, McMaster University, 1280 Main Street West, MIP Suite 309A, Hamilton, ON, L8S 4K1, - - 2014
The aim of this systematic review was to determine whether B-type natriuretic peptide (BNP) and N-terminal proBNP (NT-proBNP) independently add incremental value for predicting mortality and morbidity in patients with acute decompensated heart failure (ADHF). Medline(®), Embase™, AMED, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, and ...
Porter Stephen - - 2014
Background There is no universally accepted, precise definition, nor standardisation in terminology and classification of halitosis.Objective To propose a new definition, free from subjective descriptions (faecal, fish odour, etc), one-time sulphide detector readings and organoleptic estimation of odour levels, and excludes temporary exogenous odours (for example, from dietary sources). Some ...
Aydin M - - 2014
Background There is no universally accepted, precise definition, nor standardisation in terminology and classification of halitosis.Objective To propose a new definition, free from subjective descriptions (faecal, fish odour, etc), one-time sulphide detector readings and organoleptic estimation of odour levels, and excludes temporary exogenous odours (for example, from dietary sources). Some ...
Liu Danhong D 1 Institute for Health Informatics, Fourth Military Medical University, Xi'an, - - 2014
From the point of view of clinical data representation, this study attempted to identify obstacles in translating clinical narrative guidelines into computer interpretable format and integrating the guidelines with data in Electronic Health Records in China. Based on SAGE and K4CARE formulism, a Chinese clinical practice guideline for hypertension was ...
Htun N M NM Professor Karlheinz Peter, Baker IDI Heart and Diabetes Institute, 75 Commercial Road, Melbourne, VIC, 3004, - - 2014
Potential biomarkers have been investigated using proteomic studies in a variety of diseases. Some biomarkers have central roles in both diagnosis and monitoring of various disorders in clinical medicine, such as troponins, brain natriuretic peptide, and C-reactive protein. Although several biomarkers have been suggested in human abdominal aortic aneurysm (AAA), ...
van der Velde A Rogier AR Department of Cardiology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9713 GZ, Groningen, The - - 2014
Risk prediction in patients admitted with acute decompensated heart failure (ADHF) remains a challenge. Biomarkers may improve risk prediction, which in turn may help to better inform patients regarding short-term and long-term prognosis, therapy and care. Most data on biomarkers have been derived from patient cohorts with chronic heart failure. ...
Zheng Yinan Y Institute for Public Health and Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA - - 2014
MicroRNAs (miRNAs) are short single-stranded non-coding molecules that usually function as negative regulators to silence or suppress gene expression. Due to interested in the dynamic nature of the miRNA and reduced microarray and sequencing costs, a growing number of researchers are now measuring high-dimensional miRNAs expression data using repeated or ...
Bestwick Jonathan P JP Wolfson Institute of Preventive Medicine, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ - - 2014
Nuchal translucency (NT) is a useful marker in antenatal screening for Down's syndrome in the late first trimester of pregnancy. NT measurements increase with increasing crown rump length (CRL) so multiple of the median (MoM) values are used to allow for this. Log-linear and log-quadratic regressions of NT in relation ...
Kerkhofs Tma T 1Department of Internal Medicine, Máxima Medical Center, Eindhoven/Veldhoven, the Netherlands 2Department of Clinical Pharmacology, Máxima Medical Center, Eindhoven/Veldhoven, the Netherlands 3Department of Clinical Pharmacy & Toxicology, Leiden University Medical Center, Leiden, the Netherlands 4Department of Clinical Pharmacy & Toxicology, Maastricht University Medical Center+, Maastricht, the Netherlands 5CAPHRI, School for Public Health and Primary Care, Maastricht University Medical Center+, Maastricht, the Netherlands 6Department of Clinical Oncology, Leiden University Medical Center, Leiden, the Netherlands 7Department of Internal Medicine, Division of General Internal Medicine, Maastricht University Medical Center+, Maastricht, the - - 2014
Mitotane is the drug of choice in medical treatment of adrenocortical carcinoma. The anti-neoplastic effect appears to be correlated with a minimum plasma level of 14mg/L, but plasma concentration build-up is in general slow due to the long elimination half-life. Consequently, the therapeutic effect sets in after weeks or even ...
Phillips Martin B MB U.S. Environmental Protection Agency, National Exposure Research Laboratory, 109 TW Alexander Dr, Research Triangle Park, NC, USA 27709. Electronic address: - - 2014
Biomonitoring data are now available for hundreds of chemicals through state and national health surveys. Exposure guidance values also exist for many of these chemicals. Several methods are frequently used to evaluate biomarker data with respect to a guidance value. The "biomonitoring equivalent" (BE) approach estimates a single biomarker concentration ...
Noisel Nolwenn N Department of Environmental and Occupational Health, Chair of Toxicological Risk Assessment and Management and Université de Montréal Public Health Research Institute (IRSPUM), University of Montreal, P.O. Box 6128, Main Station, Montreal, Quebec, Canada H3 C 3J7. Electronic address: - - 2014
Biomonitoring is increasingly used to assess exposure to selenium (Se) in the population. However, there is little harmonization among protocols used in the different studies (varying biological matrices, differences in expression of results (concentrations versus amounts, units)). This makes inter-comparison of biomonitoring results across studies difficult. From a public health ...
Pufulete Maria - - 2014
Several aggregate data meta-analyses suggest that treatment guided by the serum concentration of natriuretic peptides (B-type natriuretic peptide (BNP) or its derivative N-terminal pro-B-type natriuretic peptide (NT-BNP)) reduces all-cause mortality compared with usual care in patients with heart failure (HF). We propose to conduct a meta-analysis using individual participant data ...
Zhang Xia X Department of Beijing Key Laboratory of Drug Resistance Tuberculosis Research, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing, - - 2014
A proteomic analysis was performed to screen the potential latent tuberculosis infection (LTBI) biomarkers. A training set of spectra was used to generate diagnostic models, and a blind testing set was used to determine the accuracy of the models. Candidate peptides were identified using nano-liquid chromatography-electrospray ionization-tandem mass spectrometry. Based ...
Razavi Asghar M - - 2014
Designing peptidomimetic compounds to have a pre-organized structure in solution is highly non-trivial. To show how simulation-based approaches can help speed this process, we performed an extensive simulation study of designed cyclic peptide mimics of a β-hairpin from bacterial protein LapD involved in a protein-protein interaction (PPI) pertinent to bacterial ...
Fojtikova I I National Radiation Protection Institute, Bartoškova 28, Prague 4 140 00, Czech - - 2014
Due to the large number of subsidies for energy-saving reconstructions granted, and expecting a strong influence of reconstruction on the radon level in building, the long-term measurements of radon concentration are offered free of charge to kindergartens in the Czech Republic. Classrooms and playrooms where the radon levels exceeded the ...
Xue Jintao J West China School of Pharmacy, Sichuan University, Chengdu 610041, People's Republic of - - 2014
The goal of this research was to develop a method for noninvasive blood glucose assay. Near-infrared (NIR) spectroscopy and Raman spectroscopy, two more promising techniques compared to other methods, were investigated in two kinds of artificial plasma (AP). Calibration models were generated by performing partial least squares (PLS) regression and ...
Hou Siyuan S University of Prince Edward Island, Department of Health Management, Atlantic Veterinary College, Charlottetown, PEI, C1A 4P3 - - 2014
A rapid, simple, and inexpensive method to measure the immunoglobulin G (IgG) concentrations in blood samples in human and veterinary medicine is highly desired. Infrared spectroscopy (coupled with chemometric manipulation of spectral data) has the advantages of simple sample preparation, rapid implementation of analysis, and low cost. Here a method ...
Heck Alexander - - 2014
Charge transfer in peptides and proteins can occur on different pathways, depending on the energetic landscape as well as the coupling between the involved orbitals. Since details of the mechanism and pathways are difficult to access experimentally, different modeling strategies have been successfully applied to study these processes in the ...
Harcourt Peter Rex PR Australian Football League, Melbourne, Victoria, - - 2014
The World Anti-Doping Agency (WADA) is introducing enhancements to doping investigations in its 2015 Code, which include improved sharing of information between antidoping organisations (including sporting bodies) and enhanced accountability of athlete support staff. These additions will improve the control of links between sports doping and organised crime. In February ...
Lobo D S S DS Addictions Program and Neurogenetics Laboratory, Centre for Addiction and Mental Health, 33 Russell St., R3020, Toronto, ON M5S 2S1, Canada; Department of Psychiatry, University of Toronto, 250 College St., R129, Toronto, ON M5T 1R8, Canada. Electronic address: - - 2014
Pathological gambling (PG) is a heterogeneous disorder. The identification and characterization of PG subtypes could lead to tailored treatment approaches, which may, in turn, improve treatment outcomes. To investigate PG subtypes based on personality traits across two different cultural and clinical settings. Consistent with the Pathways Model, we hypothesized the ...
Frankel Adam S AS Marine Acoustics, Inc., 4100 North Fairfax Drive, Suite 730, Arlington, Virginia - - 2014
Whistles of bottlenose dolphins (Tursiops truncatus) and Atlantic spotted dolphins (Stenella frontalis) in the eastern Gulf of Mexico were recorded and measured with a calibrated towed hydrophone array. Surveys encountered groups of both bottlenose (N = 10) and spotted dolphins (N = 5). Analysis of those data produced 1695 bottlenose dolphin whistles and 1273 ...
Du Hai-Li HL State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, - - 2014
In this contribution, a multiplicative effects model with a parameter accounting for the variations in overall sensitivity over time was proposed to reduce the effects of signal instability on quantitative results of LC-MS/MS. This method allows the use of calibration models constructed from large standard sets without having to repeat ...
Knudsen Anders Dahl AD Interdisciplinary Nanoscience Center (iNANO), Aarhus University, Gustav Wieds Vej 10C, DK - 8000 Aarhus C, - - 2014
We describe Condenser, a freely available, comprehensive open-source tool for merging multidimensional quantitative proteomics data from the Matrix Science Mascot Distiller Quantitation Toolbox into a common format ready for subsequent bioinformatic analysis. A number of different relative quantitation technologies, such as metabolic (15)N and amino acid stable isotope incorporation, label-free ...
Shen Hujun H Laboratory of Molecular Modeling and Design, State key Laboratory of Molecular Reaction Dynamics, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Rd. Dalian 116023, PR - - 2014
Gay-Berne anisotropic potential has been widely used to evaluate the non-bonded interactions between coarse-grained particles being described as elliptical rigid bodies. In this paper, we are presenting a coarse-grained model for twenty kinds of amino acids and proteins, based on the anisotropic Gay-Berne and point electric multipole (EMP) potentials. We ...
Sarpietro Maria G MG Section of Pharmaceutical Technology, Department of Drug Sciences, University of Catania, Viale A. Doria, 6, 95125 Catania, Italy. Electronic address: - - 2014
The interaction between an amphiphilic luteinizing hormone-releasing hormone (LHRH) prodrug that incorporated a lipoamino acid moiety (C12-LAA) with biological membrane models that consisted of multilamellar liposomes (MLVs) and phospholipid monolayers, was studied using Differential Scanning Calorimetry (DSC) and Langmuir-Blodgett film techniques. The effect of the prodrug C12[Q(1)]LHRH on the lipid ...
Nishida K K Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama 223-8522, - - 2014
LINAC4 H(-) source is radio frequency (RF) driven type source. In the RF system, it is required to match the load impedance, which includes H(-) source, to that of final amplifier. We model RF plasma inside the H(-) source as circuit elements using transformer model so that characteristics of the ...
Goudarzi N N Faculty of Chemistry, Shahrood University of Technology, Shahrood, Iran. Electronic address: - - 2014
In this work, a quantitative structure-retention relationship (QSRR) investigation was carried out based on the new method of random forests (RF) for prediction of the retention indices (RIs) of some polycyclic aromatic hydrocarbon (PAH) compounds. The RIs of these compounds were calculated using the theoretical descriptors generated from their molecular ...
Dai Zhijun Z Hunan Provincial Key Laboratory for Germplasm Innovation and Utilization of Crop, Hunan Agricultural University, Changsha, China, - - 2014
In this paper, we present a pipeline to perform improved QSAR analysis of peptides. The modeling involves a double selection procedure that first performs feature selection and then conducts sample selection before the final regression analysis. Five hundred and thirty-one physicochemical property parameters of amino acids were used as descriptors ...
Bragagni M M Department of Chemistry, University of Florence, via U Schiff 6, 50019 Sesto Fiorentino, Firenze, - - 2014
A niosomal formulation, functionalized with N-palmitoylglucosamine, was developed as potential brain targeted delivery system of dynorphin-B. In fact, this endogenous neuropeptide, selective agonist of k opioid receptors, is endowed with relevant pharmacological activities on the central nervous system, including a marked antinociceptive effect, but is unable to cross the blood ...
Axell Richard G RG Medical Physics and Clinical Engineering, Addenbrookes Hospital, Cambridge University Hospitals NHS Foundation Trust, UK; Postgraduate Medical Institute, Anglia Ruskin University, - - 2014
To determine the effect of different ultrasound machine-probe combinations on the observed nuchal translucency (NT) measurement and assess how this impacts on the accuracy of the NT derived component of first trimester trisomy 21 syndrome screening. Sixteen different ultrasound machine-probe combinations were used for axial measurement of 2.0, 3.0 and ...
Kun-Rodrigues Célia C Instituto Gulbenkian de Ciência, Oeiras, - - 2014
Propithecus coquereli is one of the last sifaka species for which no reliable and extensive density estimates are yet available. Despite its endangered conservation status [IUCN, 2012] and recognition as a flagship species of the northwestern dry forests of Madagascar, its population in its last main refugium, the Ankarafantsika National ...
Jewett Ethan M EM Department of Biology, Stanford University, 371 Serra Mall, Stanford, CA 94305-5020, USA. Electronic address: - - 2014
Under the coalescent model, the random number nt of lineages ancestral to a sample is nearly deterministic as a function of time when nt is moderate to large in value, and it is well approximated by its expectation E[nt]. In turn, this expectation is well approximated by simple deterministic functions ...
Hynek Martin M Gennet, Centre for Fetal Medicine and Reproductive Genetics, Prague, Czech Republic; Institute of Hygiene and Epidemiology, First Faculty of Medicine, Charles University, Prague, Czech Republic; Department of Gynecology and Obstetrics, Thomayer Hospital, Prague, Czech - - 2014
To design an exponentially weighted moving average (EWMA) chart for the quality review of nuchal translucency (NT) and to assess its performance compared to the methods currently in use: retrospective distribution-based methods and the cumulative sum (CUSUM) chart. The EWMA model was designed for NT quality review using simulation. The ...
Hjollund Niels Henrik Ingvar NH 0000-0002-6697-6597 WestChronic, Regional Hospital West Jutland, Herning, Denmark. - - 2014
Patient-reported outcome (PRO) measures may be used at a group level for research and quality improvement and at the individual patient level to support clinical decision making and ensure efficient use of resources. The challenges involved in implementing PRO measures are mostly the same regardless of aims and diagnostic groups ...
Pakdaman Nashmin N Department of Biomedical Engineering & Medical Physics, Tehran University of Medical Sciences, Tehran, - - 2014
Increased nuchal translucency (NT) thickness is associated with major abnormalities of the heart, great arteries and a wide range of genetic syndromes. NT thickness is one of the most important ultrasound markers in fetal diseases screening. To find an applicable method that accurately detects NT, we use an algorithm based ...
Canuel Magalie M Institut national de santé publique du Québec (INSPQ), Québec City, - - 2014
The adoption of pro-environmental behaviours reduces anthropogenic environmental impacts and subsequent human health effects. This study developed composite indices measuring adoption of pro-environmental behaviours at the household level in Canada. The 2007 Households and the Environment Survey conducted by Statistics Canada collected data on Canadian environmental behaviours at households' level. ...
Söderholm Sandra S Institute of Biotechnology, University of Helsinki, P.O. Box 65 (Viikinkaari 1), FI-00014 Helsinki, - - 2014
It is possible to identify thousands of phosphopeptides and -proteins in a single experiment with mass spectrometry-based phosphoproteomics. However, a current bottleneck is the downstream data analysis which is often laborious and requires a number of manual steps. Toward automating the analysis steps, we have developed and implemented a software, ...
Sun Jian J Division of Biomedical Engineering, University of Saskatchewan, 57 Campus Dr, S7N 5A9 Saskatoon, SK, - - 2014
A real-time peptide-spectrum matching (RT-PSM) algorithm is a database search method to interpret tandem mass spectra (MS/MS) with strict time constraints. Restricted by the hardware and architecture of individual workstation, previous RT-PSM algorithms either are not fast enough to satisfy all real-time system requirements or need to sacrifice the level ...
Galopin Alexandre A Vidal, Issy-les-Moulineaux, - - 2014
Every year, numerous clinical practice guidelines (CPGs) are published on a same topic. They may be conflicting, thus infringing clinicians' confidence in adhering to them. In order to build a clinical decision support system to assist GPs in the management of hypertension, we have considered three recent CPGs written in ...
Kamran Aziz A Department of Public Health, School of Health, Ardabil University of Medical Sciences, Ardabil, - - 2014
Measurement tools designed to ensure the achievements of studies' objectives must be evaluated. Based on the health promotion model (HPM), the present study was conducted to assess the validity and reliability of the designed questionnaire of hypertensive patients' nutritional perceptions. In a cross-sectional study, the mentioned questionnaire was assessed based ...
Lopes Pedro E M PE Department of Pharmaceutical Sciences, University of Maryland, School of Pharmacy, 20 Penn Street HSFII, Baltimore, Maryland 21201, - - 2013
Presented is a polarizable force field based on a classical Drude oscillator framework, currently implemented in the programs CHARMM and NAMD, for modeling and molecular dynamics (MD) simulation studies of peptides and proteins. Building upon parameters for model compounds representative of the functional groups in proteins, the development of the ...
Bottaro Sandro S Department of Biology, University of Copenhagen, Copenhagen, Denmark ; Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 9000 Rockville Pike, U.S.A. ; SISSA-Scuola Internazionale Superiore di Studi Avanzati,Trieste, - - 2013
The development of accurate implicit solvation models with low computational cost is essential for addressing many large-scale biophysical problems. Here, we present an efficient solvation term based on a Gaussian solvent-exclusion model (EEF1) for simulations of proteins in aqueous environment, with the primary aim of having a good overlap with ...
Apaydın Fazıl - - 2013
The goal of this article is to present a system for standardized documentation of the findings obtained during the examination of the nose. Three levels of data recording have been established for various purposes: (1) First level: Septum-lateral nasal wall (SL) classification, (2) Second level: SL classification including seven drawings, ...
Münz Andreas - - 2013
In dressage riding the pelvis of the rider interacts with the horse physically. However, there is little information about the influence of riding skill on the interaction of the human pelvis with the horse. Therefore this paper aims to study the interaction between horse and rider in professional riders (PRO) ...
Isci Senol - - 2013
Reverse engineering gene interaction networks from experimental data is a challenging task due to the complex nature of the networks and the noise inherent in the data. One way to overcome these hurdles would be incorporating the vast amounts of external biological knowledge when building interaction networks. We propose a ...
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