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Sun Jian - - 2014
A real-time peptide-spectrum matching (RT-PSM) algorithm is a database search method to interpret tandem mass spectra (MS/MS) with strict time constraints. Restricted by the hardware and architecture of individual workstation, previous RT-PSM algorithms either are not fast enough to satisfy all real-time system requirements or need to sacrifice the level ...
Xue Jintao J West China School of Pharmacy, Sichuan University, Chengdu 610041, People's Republic of - - 2014
The goal of this research was to develop a method for noninvasive blood glucose assay. Near-infrared (NIR) spectroscopy and Raman spectroscopy, two more promising techniques compared to other methods, were investigated in two kinds of artificial plasma (AP). Calibration models were generated by performing partial least squares (PLS) regression and ...
Hou Siyuan S University of Prince Edward Island, Department of Health Management, Atlantic Veterinary College, Charlottetown, PEI, C1A 4P3 - - 2014
A rapid, simple, and inexpensive method to measure the immunoglobulin G (IgG) concentrations in blood samples in human and veterinary medicine is highly desired. Infrared spectroscopy (coupled with chemometric manipulation of spectral data) has the advantages of simple sample preparation, rapid implementation of analysis, and low cost. Here a method ...
Heck Alexander - - 2014
Charge transfer in peptides and proteins can occur on different pathways, depending on the energetic landscape as well as the coupling between the involved orbitals. Since details of the mechanism and pathways are difficult to access experimentally, different modeling strategies have been successfully applied to study these processes in the ...
Harcourt Peter Rex PR Australian Football League, Melbourne, Victoria, - - 2014
The World Anti-Doping Agency (WADA) is introducing enhancements to doping investigations in its 2015 Code, which include improved sharing of information between antidoping organisations (including sporting bodies) and enhanced accountability of athlete support staff. These additions will improve the control of links between sports doping and organised crime. In February ...
Lobo D S S DS Addictions Program and Neurogenetics Laboratory, Centre for Addiction and Mental Health, 33 Russell St., R3020, Toronto, ON M5S 2S1, Canada; Department of Psychiatry, University of Toronto, 250 College St., R129, Toronto, ON M5T 1R8, Canada. Electronic address: - - 2014
Pathological gambling (PG) is a heterogeneous disorder. The identification and characterization of PG subtypes could lead to tailored treatment approaches, which may, in turn, improve treatment outcomes. To investigate PG subtypes based on personality traits across two different cultural and clinical settings. Consistent with the Pathways Model, we hypothesized the ...
Frankel Adam S AS Marine Acoustics, Inc., 4100 North Fairfax Drive, Suite 730, Arlington, Virginia - - 2014
Whistles of bottlenose dolphins (Tursiops truncatus) and Atlantic spotted dolphins (Stenella frontalis) in the eastern Gulf of Mexico were recorded and measured with a calibrated towed hydrophone array. Surveys encountered groups of both bottlenose (N = 10) and spotted dolphins (N = 5). Analysis of those data produced 1695 bottlenose dolphin whistles and 1273 ...
Du Hai-Li HL State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, - - 2014
In this contribution, a multiplicative effects model with a parameter accounting for the variations in overall sensitivity over time was proposed to reduce the effects of signal instability on quantitative results of LC-MS/MS. This method allows the use of calibration models constructed from large standard sets without having to repeat ...
Knudsen Anders Dahl AD Interdisciplinary Nanoscience Center (iNANO), Aarhus University, Gustav Wieds Vej 10C, DK - 8000 Aarhus C, - - 2014
We describe Condenser, a freely available, comprehensive open-source tool for merging multidimensional quantitative proteomics data from the Matrix Science Mascot Distiller Quantitation Toolbox into a common format ready for subsequent bioinformatic analysis. A number of different relative quantitation technologies, such as metabolic (15)N and amino acid stable isotope incorporation, label-free ...
Shen Hujun H Laboratory of Molecular Modeling and Design, State key Laboratory of Molecular Reaction Dynamics, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Rd. Dalian 116023, PR - - 2014
Gay-Berne anisotropic potential has been widely used to evaluate the non-bonded interactions between coarse-grained particles being described as elliptical rigid bodies. In this paper, we are presenting a coarse-grained model for twenty kinds of amino acids and proteins, based on the anisotropic Gay-Berne and point electric multipole (EMP) potentials. We ...
Sarpietro Maria G MG Section of Pharmaceutical Technology, Department of Drug Sciences, University of Catania, Viale A. Doria, 6, 95125 Catania, Italy. Electronic address: - - 2014
The interaction between an amphiphilic luteinizing hormone-releasing hormone (LHRH) prodrug that incorporated a lipoamino acid moiety (C12-LAA) with biological membrane models that consisted of multilamellar liposomes (MLVs) and phospholipid monolayers, was studied using Differential Scanning Calorimetry (DSC) and Langmuir-Blodgett film techniques. The effect of the prodrug C12[Q(1)]LHRH on the lipid ...
Nishida K K Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama 223-8522, - - 2014
LINAC4 H(-) source is radio frequency (RF) driven type source. In the RF system, it is required to match the load impedance, which includes H(-) source, to that of final amplifier. We model RF plasma inside the H(-) source as circuit elements using transformer model so that characteristics of the ...
Goudarzi N N Faculty of Chemistry, Shahrood University of Technology, Shahrood, Iran. Electronic address: - - 2014
In this work, a quantitative structure-retention relationship (QSRR) investigation was carried out based on the new method of random forests (RF) for prediction of the retention indices (RIs) of some polycyclic aromatic hydrocarbon (PAH) compounds. The RIs of these compounds were calculated using the theoretical descriptors generated from their molecular ...
Dai Zhijun Z Hunan Provincial Key Laboratory for Germplasm Innovation and Utilization of Crop, Hunan Agricultural University, Changsha, China, - - 2014
In this paper, we present a pipeline to perform improved QSAR analysis of peptides. The modeling involves a double selection procedure that first performs feature selection and then conducts sample selection before the final regression analysis. Five hundred and thirty-one physicochemical property parameters of amino acids were used as descriptors ...
Bragagni M M Department of Chemistry, University of Florence, via U Schiff 6, 50019 Sesto Fiorentino, Firenze, - - 2014
A niosomal formulation, functionalized with N-palmitoylglucosamine, was developed as potential brain targeted delivery system of dynorphin-B. In fact, this endogenous neuropeptide, selective agonist of k opioid receptors, is endowed with relevant pharmacological activities on the central nervous system, including a marked antinociceptive effect, but is unable to cross the blood ...
Axell Richard G RG Medical Physics and Clinical Engineering, Addenbrookes Hospital, Cambridge University Hospitals NHS Foundation Trust, UK; Postgraduate Medical Institute, Anglia Ruskin University, - - 2014
To determine the effect of different ultrasound machine-probe combinations on the observed nuchal translucency (NT) measurement and assess how this impacts on the accuracy of the NT derived component of first trimester trisomy 21 syndrome screening. Sixteen different ultrasound machine-probe combinations were used for axial measurement of 2.0, 3.0 and ...
Kun-Rodrigues Célia C Instituto Gulbenkian de Ciência, Oeiras, - - 2014
Propithecus coquereli is one of the last sifaka species for which no reliable and extensive density estimates are yet available. Despite its endangered conservation status [IUCN, 2012] and recognition as a flagship species of the northwestern dry forests of Madagascar, its population in its last main refugium, the Ankarafantsika National ...
Jewett Ethan M EM Department of Biology, Stanford University, 371 Serra Mall, Stanford, CA 94305-5020, USA. Electronic address: - - 2014
Under the coalescent model, the random number nt of lineages ancestral to a sample is nearly deterministic as a function of time when nt is moderate to large in value, and it is well approximated by its expectation E[nt]. In turn, this expectation is well approximated by simple deterministic functions ...
Hynek Martin M Gennet, Centre for Fetal Medicine and Reproductive Genetics, Prague, Czech Republic; Institute of Hygiene and Epidemiology, First Faculty of Medicine, Charles University, Prague, Czech Republic; Department of Gynecology and Obstetrics, Thomayer Hospital, Prague, Czech - - 2014
To design an exponentially weighted moving average (EWMA) chart for the quality review of nuchal translucency (NT) and to assess its performance compared to the methods currently in use: retrospective distribution-based methods and the cumulative sum (CUSUM) chart. The EWMA model was designed for NT quality review using simulation. The ...
Hjollund Niels Henrik Ingvar NH 0000-0002-6697-6597 WestChronic, Regional Hospital West Jutland, Herning, Denmark. - - 2014
Patient-reported outcome (PRO) measures may be used at a group level for research and quality improvement and at the individual patient level to support clinical decision making and ensure efficient use of resources. The challenges involved in implementing PRO measures are mostly the same regardless of aims and diagnostic groups ...
Pakdaman Nashmin N Department of Biomedical Engineering & Medical Physics, Tehran University of Medical Sciences, Tehran, - - 2014
Increased nuchal translucency (NT) thickness is associated with major abnormalities of the heart, great arteries and a wide range of genetic syndromes. NT thickness is one of the most important ultrasound markers in fetal diseases screening. To find an applicable method that accurately detects NT, we use an algorithm based ...
Lopes Pedro E M PE Department of Pharmaceutical Sciences, University of Maryland, School of Pharmacy, 20 Penn Street HSFII, Baltimore, Maryland 21201, - - 2013
Presented is a polarizable force field based on a classical Drude oscillator framework, currently implemented in the programs CHARMM and NAMD, for modeling and molecular dynamics (MD) simulation studies of peptides and proteins. Building upon parameters for model compounds representative of the functional groups in proteins, the development of the ...
Apaydın Fazıl - - 2013
The goal of this article is to present a system for standardized documentation of the findings obtained during the examination of the nose. Three levels of data recording have been established for various purposes: (1) First level: Septum-lateral nasal wall (SL) classification, (2) Second level: SL classification including seven drawings, ...
Münz Andreas - - 2013
In dressage riding the pelvis of the rider interacts with the horse physically. However, there is little information about the influence of riding skill on the interaction of the human pelvis with the horse. Therefore this paper aims to study the interaction between horse and rider in professional riders (PRO) ...
Isci Senol - - 2013
Reverse engineering gene interaction networks from experimental data is a challenging task due to the complex nature of the networks and the noise inherent in the data. One way to overcome these hurdles would be incorporating the vast amounts of external biological knowledge when building interaction networks. We propose a ...
Harnly James - - 2013
The AOAC INTERNATIONAL guidelines for validation of botanical identification methods were applied to the detection of Asian Ginseng [Panax ginseng (PG)] as an adulterant for American Ginseng [P. quinquefolius (PQ)] using spectral fingerprints obtained by flow injection mass spectrometry (FIMS). Samples of 100% PQ and 100% PG were physically mixed ...
Yoon Hyun Joong - - 2013
This paper addresses the emotion recognition problem from electroencephalogram signals, in which emotions are represented on the valence and arousal dimensions. Fast Fourier transform analysis is used to extract features and the feature selection based on Pearson correlation coefficient is applied. This paper proposes a probabilistic classifier based on Bayes' ...
Soo O Y M - - 2013
Ligophorus belanaki n. sp. and Ligophorus kederai n. sp. are described from Liza subviridis Valenciennes, 1836 and Valamugil buchanani Bleeker, 1854, respectively. Ligophorus kederai n. sp. has fenestrated ventral anchors, while in L. belanaki n. sp. the ventral anchor is not fenestrated. Ligophorus belanaki n. sp. is similar to L. ...
Sylvester Karl G - - 2013
Necrotising enterocolitis (NEC) is a major source of neonatal morbidity and mortality. The management of infants with NEC is currently complicated by our inability to accurately identify those at risk for progression of disease prior to the development of irreversible intestinal necrosis. We hypothesised that integrated analysis of clinical parameters ...
Nambi Vijay - - 2013
Among the various cardiovascular diseases, heart failure (HF) is projected to have the largest increases in incidence over the coming decades; therefore, improving HF prediction is of significant value. We evaluated whether cardiac troponin T (cTnT) measured with a high-sensitivity assay and N-terminal pro-B-type natriuretic peptide (NT-proBNP), biomarkers strongly associated ...
Kubelka Jan - - 2013
Changes in the amide I' IR band with temperature are widely used for elucidation of peptide and protein conformational transitions and folding equilibria. Since amide I' exhibits inherent temperature dependent frequency shifts, standard mixture analysis methods are not applicable. To reliably extract the true thermodynamic states, frequency shifts of the ...
Underwood Graham J C GJ School of Biological Sciences, University of Essex, Colchester, Essex CO4 3SQ, United - - 2013
Sea ice can contain high concentrations of dissolved organic carbon (DOC), much of which is carbohydrate-rich extracellular polymeric substances (EPS) produced by microalgae and bacteria inhabiting the ice. Here we report the concentrations of dissolved carbohydrates (dCHO) and dissolved EPS (dEPS) in relation to algal standing stock [estimated by chlorophyll ...
Rosato J - - 2013
The divergence that occurs at large impact parameters in Stark collision operators is examined for low-density hydrogen plasmas. In a previous work [J. Rosato, H. Capes, and R. Stamm, Phys. Rev. E 86, 046407 (2012)], we showed that the correlations between a radiating atom and the charged particles surrounding it ...
Oeding Kristi K Division of Adult Audiology, Department of Otolaryngology-Head and Neck Surgery, Washington University in St. Louis School of - - 2013
Current bone anchored hearing solutions (BAHSs) have incorporated automatic adaptive multichannel directional microphones (DMs). Previous fixed single-channel hypercardioid DMs in BAHSs have provided benefit in a diffuse listening environment, but little data are available on the performance of adaptive multichannel DMs in BAHSs for persons with unilateral sensorineural hearing loss ...
Cao Yanguang - - 2013
Minimal physiologically-based pharmacokinetic (mPBPK) models provide a sensible modeling approach when fitting only plasma (or blood) data yielding physiologically-relevant PK parameters that may provide more practical value than parameters of mammillary models. We propose a second-generation mPBPK model specifically for monoclonal antibodies (mAb) by including (lumping) several essential components of ...
Kong Sing Teang - - 2013
To establish using dried blood spot (DBS) as a surrogate to plasma for therapeutic drug monitoring (TDM) of carbamazepine (CBZ), we compared the population pharmacokinetic (PPK) estimates from concurrent DBS and plasma levels. The dose-concentration relationship, estimated parameter and variability were determined. A total of 98 observations from 97 people ...
Yadav Amit Kumar - - 2013
Statistical validation of peptide assignments from a large scale shotgun proteomics experiment is a critical step and various methods for evaluating significance based on decoy database search are in practice. False Discovery Rate (FDR) estimation of peptide assignments assesses global significance and corrects for multiple comparisons. Various approaches have been ...
Schenone Agustina V - - 2013
In this work, we present the development of a method for the determination of doxorubicin in plasma samples in the presence of an unexpected component (riboflavin) by using total synchronous fluorescence spectroscopic data matrices. To the best of our knowledge, this is the first time that the second-order advantage is ...
Surinova Silvia - - 2013
Targeted proteomics based on selected reaction monitoring (SRM) mass spectrometry is commonly used for accurate and reproducible quantification of protein analytes in complex biological mixtures. Strictly hypothesis-driven, SRM assays quantify each targeted protein by collecting measurements on its peptide fragment ions, called transitions. To achieve sensitive and accurate quantitative results, ...
Wang Baozhen - - 2013
This paper investigates the biases associated with the ground-level nitrogen dioxide (NO2) concentrations derived from the satellite Ozone Monitoring Instrument (OMI) NO2 data through comparisons with the modeling and the monitoring results for the state of California in 2008. The seasonal and annual average ground-level NO2 concentrations are both analyzed ...
Porteliusa Erik - - 2013
Alzheimer's disease (AD) is a slowly progressing disease and the evaluation of clinical effects of candidate drugs requires large clinical cohorts as well as long treatment trials. There is a great need for central biomarkers and translatable pre-clinical models to provide early indication of treatment effects. We set out to ...
Uslan Volkan - - 2013
High dimensional, complex and non-linear nature of the post-genome data often adversely affects the performance of predictive models. There are two methods that have been widely used to model such non-linear systems, namely Fuzzy System (FS) and Support Vector Machine (SVM). FS is good at modelling uncertainty and yielding a ...
Dupont Emmanuelle - - 2013
Hierarchical structures in road safety data are receiving increasing attention in the literature and multilevel (ML) models are proposed for appropriately handling the resulting dependences among the observations. However, so far no empirical synthesis exists of the actual added value of ML modelling techniques as compared to other modelling approaches. ...
Takahara Mitsuyoshi - - 2013
The screening of dysglycemia in the non-fasting state is a challenging issue in healthcare practice. We investigated whether the additional measurement of circulating adiponectin levels could improve screening performance. We used a database of 1190 Japanese employees with metabolic risk factors, who underwent a 75-g oral glucose tolerance test (OGTT), ...
Lin Hao - - 2013
MOTIVATION: Label-free quantification is an important approach to identify biomarkers as it measures the quantity change of peptides across different biological samples. One of the fundamental steps for label-free quantification is to match the peptide features that are detected in two datasets to each other. Although ad hoc software tools ...
Stern Stephan T - - 2013
Pharmacokinetic modeling and simulation is a powerful tool for the prediction of drug concentrations in the absence of analytical techniques that allow for direct quantification. The present study applied this modeling approach to determine active drug release from a nanoparticle prodrug formulation. A comparative pharmacokinetic study of a nanoscale micellar ...
Drolet Jean-Philippe - - 2013
The aim of this paper is to present the first step of a new approach to make a map of radonprone areas showing different potential radon emission levels in the Quebec province. This map is a tool intended to assist the Quebec government in identifying populations with a higher risk ...
Salomon Lj - - 2013
OBJECTIVE: Previous studies have recommended to repeat nuchal translucency (NT) measurements several times in order to optimize the sensitivity of the screening process. However, truncation is applied within the risk calculation for small NT measurements, therefore repeating NT measurements in the lower range might be useless and time consuming. We ...
Hobart Jeremy - - 2013
BACKGROUND: The increasing influence of patient-reported outcome (PRO) measurement instruments indicates their scrutiny has never been more crucial. Above all, PRO instruments should be valid: shown to assess what they purport to assess. OBJECTIVES: To evaluate a widely used fatigue PRO instrument, highlight key issues in understanding PRO instrument validity, ...
Gotta Verena - - 2013
: Several population pharmacokinetic (PPK) analyses of the anticancer drug imatinib have been performed to investigate different patient populations and covariate effects. The present analysis offers a systematic qualitative and quantitative summary and comparison of those. Its primary objective was to provide useful information for evaluating the expectedness of imatinib ...
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