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Winkelman A M AM LIC, Private Bag 3016, Hamilton, 3240, New Zealand. Electronic address: - - 2014
A hybrid method of estimating genomically enhanced breeding values (GEBV) that uses features of a single-step approach and traditional national estimated breeding value (EBV), based on pedigree, as the starting point was developed and assessed. The method uses deregressed EBV from the traditional EBV estimation procedures and a pedigree matrix ...
Piles M M Genetica i Millora Animal, Institut de Recerca i Tecnologia Agroalimentàries, Torre Marimon s/n, 08140, Caldes de Montbui, Barcelona, Spain - - 2014
Response on litter size ( LS: ) to selection based on EBV of the own trait and several indexes including EBV of one or more parameters of a reaction norm model ( RNM: ) was evaluated by simulation. The RNM described animal's performance under different environmental temperatures assuming that this ...
Mirkes E M EM Department of Mathematics, University of Leicester, Leicester LE1 7RH, - - 2014
The canine lymphoma blood test detects the levels of two biomarkers, the acute phase proteins (C-Reactive Protein and Haptoglobin). This test can be used for diagnostics, for screening, and for remission monitoring as well. We analyze clinical data, test various machine learning methods and select the best approach to these ...
Zhu Liqin L Tianjin First Center Hospital, Tianjin 300192, China. Electronic address: - - 2014
The purpose of this study was to explore the population pharmacokinetic features of moxifloxacin in infected patients. A total of 37 Chinese adult infected patients were treated with intravenous moxifloxacin (400 mg/day). In total, 67 plasma samples of moxifloxacin were collected immediately after intravenous dripping and before administration on the 3rd, ...
Hanif Muhammad M Department of Pharmaceutics, Faculty of Pharmacy, University of Karachi, Karachi, Pakistan / Department of Pharmacy, Bahauddin Zakariya University, Multan, - - 2014
Simple and cost effective study consisting of three steps, comparison of micromeritic properties of different blends i.e. placebo without API and Nimesulide containing, Use of central composite design (CCRD) for intermediate release Nimesulide tablets and stability results of three selected Nimesulide tablet formulations which were calculated by using R Gui. ...
Bowen Patrick K PK Department of Materials Science and Engineering, Michigan Technological University; Houghton, Michigan, - - 2014
The development of magnesium-based materials for bioabsorbable stents relies heavily on corrosion testing by immersion in pseudophysiological solutions, where magnesium degrades faster than it does in vivo. The quantitative difference in corrosion kinetics in vitro and in vivo is largely unknown, but, if determined, would help reduce dependence on animal ...
Haware Rahul V RV College of Pharmacy & Health Sciences, Campbell University, Buies Creek, North Carolina, - - 2014
This work distinguishes and quantifies the effects of bovine- and vegetable-derived magnesium stearate (MgSt) molecular and macroscopic properties on lubrication efficiency using multivariate analysis. Principal component analysis (PCA) and partial least-square regression (PLS) were used to evaluate and quantify the lubricant effectiveness on a model tablet formulation. PCA score and ...
Carter Tyler J TJ Department of Chemistry, University of Michigan - - 2014
Boron clusters are proposed as a new concept for the design of magnesium-battery electrolytes that are magnesium-battery-compatible, highly stable, and noncorrosive. A novel carborane-based electrolyte incorporating an unprecedented magnesium-centered complex anion is reported and shown to perform well as a magnesium-battery electrolyte. This finding opens a new approach towards the ...
Herrick Tara M - - 2014
PATH, an international nonprofit organization, assessed nearly 40 technologies for their potential to reduce maternal mortality from postpartum hemorrhage and preeclampsia and eclampsia in low-resource settings. The evaluation used a new Excel-based prioritization tool covering 22 criteria developed by PATH, the Maternal and Neonatal Directed Assessment of Technology (MANDATE) model, ...
Syamala Urmila Sri - - 2014
A model immunosuppressant BCS Class II drug was selected for the work to assess the formulation variables on the release rate using design of experiment (DoE) - Stat-Ease software. Surface solid dispersion was prepared with dichloromethane (DCM) and ethanol mixture (4:1), and converted to tablet by adsorption on a neutral ...
Mihailovic Zoran - - 2013
The use of magnesium as a parameter to estimate the time of death is controversial. In 32 traumatic deaths with known postmortem intervals (PMIs), small quantities of vitreous humor (VH) were sampled repetitively every 3 h until 24 h postmortem. The bodies were kept at the constant ambient temperature of 20°C (68°F). ...
Kumar Ramesh - - 2013
Modeling and simulation was carried out for an advanced membrane-integrated hybrid treatment process that ensures reuse of water with conversion and recovery of ammoniacal nitrogen as value-added struvite fertilizer from coke wastewater. While toxic cyanide was largely removed in a pre-chemical treatment unit using Fenton's reagents under optimized conditions, more ...
Moss Darren M DM Molecular and Biochemical Parasitology Group, Liverpool School of Tropical Medicine, Liverpool, UK. - - 2013
Raltegravir pharmacokinetics (PK) show high intra- and inter-patient variability and are also influenced by co-administered substances that alter the gastrointestinal tract environment, such as pH-altering or metal-containing agents. The aim of this investigation was to develop a population-based absorption, distribution, metabolism and excretion (ADME) model to investigate the effects of ...
Willumeit Regine - - 2013
Magnesium degradation under physiological conditions is a highly complex process where temperature, the use of cell culture growth medium and the presence of CO2, O2 and proteins can influence the corrosion rate and the composition of the resulting corrosion layer. Due to the complexity of this process, it is almost ...
Järvinen Kristiina - - 2013
Continuous manufacturing methods offer economic and quality advantages when compared with batch manufacturing methods. In continuous manufacturing, one requires real time assurance of quality of product via the implementation of PAT tools. This study focuses on an in-line near-infrared (NIR) spectroscopic method for determining the drug content of powder mixtures ...
Liu Yiqi Y Advanced Water Management Centre, The University of Queensland, St. Lucia, Brisbane QLD 4072, Australia E-mail: z.yuan@awmc.uq.edu.au; School of Automation Science & Engineering, South China University of Technology, Guangzhou, 510640, - - 2013
Chemicals such as magnesium hydroxide (Mg(OH)2) and iron salts are widely used to control sulfide-induced corrosion in sewer networks composed of interconnected sewer pipe lines and pumping stations. Chemical dosing control is usually non-automatic and based on experience, thus often resulting in sewage reaching the discharge point receiving inadequate or ...
Bai Jane Pf - - 2012
Prolonged use of proton pump inhibitors has reportedly caused rare clinically symptomatic hypomagnesemia. A review of literature suggests PPI drugs may impair intestinal magnesium absorption. With the goal of preventing PPI-induced hypomagnesemia, an oral absorption-centric model was developed by referencing literature data. Our modeling with human data reveals that magnesium ...
Chunmiao Yuan - - 2012
Minimum ignition temperature of dust clouds (MIT-DC) is an important consideration when adopting explosion prevention measures. This paper presents a model for determining minimum ignition temperature for a magnesium powder cloud under conditions simulating a Godbert-Greenwald (GG) furnace. The model is based on heterogeneous oxidation of metal particles and Newton's ...
Shik Jonathan Z JZ Department of Entomology, North Carolina State University, Raleigh, NC 27695, - - 2012
Social insect societies dominate many terrestrial ecosystems across the planet. Colony members cooperate to capture and use resources to maximize survival and reproduction. Yet, when compared with solitary organisms, we understand relatively little about the factors responsible for differences in the rates of survival, growth and reproduction among colonies. To ...
Genovart Meritxell - - 2012
Large-scale seasonal climatic indices, such as the North Atlantic Oscillation (NAO) index or the Southern Oscillation Index (SOI), account for major variations in weather and climate around the world and may influence population dynamics in many organisms. However, assessing the extent of climate impacts on species and their life-history traits ...
Chang De-Wei - - 2012
The effect of instrument calibration range, algal growth phase, chlorophyll-a and turbidity interference and colony size, on the measurement of phycocyanin by in-vivo fluoroscopy (IVF) was investigated. The cyanobacterial species Microcystis aeruginosa PCC 7820, Anabaena circinalis and Planktothricoides raciborskii were used to investigate variation in phycocyanin content in the different ...
Jurado José Marcos - - 2012
Spanish white wines from four production areas protected by Appellation Control laws have been analysed by inductively coupled plasma optical emission spectrometry to determine the contents of aluminium, barium, boron, calcium, chromium, copper, iron, magnesium, manganese, nickel, phosphorous, potassium, silicon, sodium, strontium, sulphur and zinc. These elements were used as ...
Hatfield Jeff S - - 2012
Globally, seabirds are vulnerable to anthropogenic threats both at sea and on land. Seabirds typically nest colonially and show strong fidelity to natal colonies, and such colonies on low-lying islands may be threatened by sea-level rise. We used French Frigate Shoals, the largest atoll in the Hawaiian Archipelago, as a ...
Williams Neal M - - 2012
Variation in the availability of food resources over space and time is a likely driver of how landscape structure and composition affect animal populations. Few studies, however, have directly assessed the spatiotemporal variation in resource availability that arises from landscape pattern, or its effect on populations and population dynamic parameters. ...
Olivieri Alejandro C - - 2012
Screening of relevant factors using Plackett-Burman designs is usual in analytical chemistry. It relies on the assumption that factor interactions are negligible; however, failure of recognizing such interactions may lead to incorrect results. Factor associations can be revealed by feature selection techniques such as ant colony optimization. This method has ...
Mertens Laurence - - 2012
Recently, the focus of predictive food microbiology has shifted towards more mechanistically-inspired modelling. Together with this trend, the need for methods that allow rapid data collection at the (intra)cellular level, as well as the intermediate subpopulation/colony level, has emerged. Although several experimental techniques are currently available to study colony dynamics ...
Eger J E JE - - 2012
Using a quarterly (3-mo) monitoring and bait-replenishment interval, 122 subterranean termite colonies throughout the United States were baited with a refined cellulose bait matrix containing 0.5% noviflumuron. All colonies were eliminated in less than 1 yr after initiation of baiting as determined by long-term monitoring and genetic markers. Sixty-three percent ...
Robins Nicholas A - - 2012
Colonial cinnabar mining and refining began in Huancavelica, Peru, in 1564. With a local source of mercury, the amalgamation process was adopted to refine silver in Potosí, Bolivia, in the early 1570s. As a result, large quantities of mercury were released into the environment. We used archival, primary, and secondary ...
Kimko Holly - - 2012
Placebo and pharmacodynamic (PD) models were developed which link temporal measures of efficacy in children with attention deficit hyperactivity disorder (ADHD) and methylphenidate (MPH) plasma concentrations from adults. These models can be used to predict daily pediatric clinical measure profiles following administration of different MPH formulations in children without conducting ...
Meng Qing-Hao - - 2012
We consider chemical plume tracing (CPT) in time-varying airflow environments using multiple mobile robots. The purpose of CPT is to approach a gas source with a previously unknown location in a given area. Therefore, the CPT could be considered as a dynamic optimization problem in continuous domains. The traditional ant ...
Cremer Jonas - - 2012
Microbes providing public goods are widespread in nature despite running the risk of being exploited by free-riders. However, the precise ecological factors supporting cooperation are still puzzling. Following recent experiments, we consider the role of population growth and the repetitive fragmentation of populations into new colonies mimicking simple microbial life-cycles. ...
Dainat Benjamin - - 2012
Across the Northern hemisphere, managed honey bee colonies, Apis mellifera, are currently affected by abrupt depopulation during winter and many factors are suspected to be involved, either alone or in combination. Parasites and pathogens are considered as principal actors, in particular the ectoparasitic mite Varroa destructor, associated viruses and the ...
Fretwell Peter T - - 2012
Our aim was to estimate the population of emperor penguins (Aptenodytes fosteri) using a single synoptic survey. We examined the whole continental coastline of Antarctica using a combination of medium resolution and Very High Resolution (VHR) satellite imagery to identify emperor penguin colony locations. Where colonies were identified, VHR imagery ...
Rawlinson Kate A - - 2012
The role of corallivory is becoming increasingly recognised as an important factor in coral health at a time when coral reefs around the world face a number of other stressors. The polyclad flatworm, Amakusaplana acroporae, is a voracious predator of Indo-Pacific acroporid corals in captivity, and its inadvertent introduction into ...
Dejean Alain - - 2012
Here we show that Daceton armigerum, an arboreal myrmicine ant whose workers are equipped with hypertrophied trap-jaw mandibles, is characterized by a set of unexpected biological traits including colony size, aggressiveness, trophobiosis and hunting behavior. The size of one colony has been evaluated at ca. 952,000 individuals. Intra- and interspecific ...
O'Brien D D The Center for Childhood Cancer, Columbus Children's Research Institute and the Department of Pediatrics, The Ohio State University, Columbus, Ohio, - - 2012
Rhabdomyosarcoma (RMS), a form of soft tissue sarcoma, is one of the most common pediatric malignancies. A complex disease with at least three different subtypes, it is characterized by perturbations in a number of signaling pathways and genetic abnormalities. Extensive clinical studies have helped classify these tumors into high and ...
Saber Nikoo R - - 2011
PURPOSE: While the goal of craniofacial reconstruction surgery is to restore the cranial head shape as much towards normal as possible, for the individual patient, there is, in fact, no normal three-dimensional (3D) model to act as a guide. In this project, we generated a library of normative pediatric skulls ...
Zöllner Alexander M AM Department of Mechanical Engineering, Stanford University, Stanford, CA 94305, - - 2012
Tissue expansion is a common surgical procedure to grow extra skin through controlled mechanical over-stretch. It creates skin that matches the color, texture, and thickness of the surrounding tissue, while minimizing scars and risk of rejection. Despite intense research in tissue expansion and skin growth, there is a clear knowledge ...
Duhaime Ann-Christine - - 2012
As part of the Traumatic Brain Injury Common Data Elements project, a large-scale effort to define common data elements across a variety of domains, including neuroimaging, special considerations for pediatric patients were introduced. This article is an extension of that initial work, in which pediatric-specific pathoanatomical entities, technical considerations, interpretation ...
Reda Fitsum A - - 2011
Cochlear implant surgery is used to implant an electrode array in the cochlea to treat hearing loss. The authors recently introduced a minimally invasive image-guided technique termed percutaneous cochlear implantation. This approach achieves access to the cochlea by drilling a single linear channel from the outer skull into the cochlea ...
Reed-Thurston Deborah - - 2011
The objectives of this review are to describe the Extracorporeal Life Support (ECLS) research at the Penn State Pediatric Cardiovascular Research evaluating new pediatric ECLS components and to discuss a proposed continuous quality improvement model after implementation of new technology. Review of current literature pertaining to studies at the Penn ...
Henson Shandelle M - - 2012
In humans, coping behaviour is an action taken to soothe oneself during or after a stressful or threatening situation. Some human behaviours with physiological functions also serve as coping behaviours, for example, comfort sucking in infants and comfort eating in adults. In birds, the behaviour of preening, which has important ...
Wu Xiaochong X Arthur and Sonia Labatt Brain Tumor Research Center, Hospital for Sick Children, Toronto, Ontario, M5G 1L7, - - 2011
Medulloblastoma is the most common malignant pediatric brain tumor. Despite its prevalence and importance in pediatric neuro-oncology, the genes and pathways responsible for its initiation, maintenance, and progression remain poorly understood. Genetically engineered mouse models are an essential tool for uncovering the molecular and cellular basis of human diseases, including ...
Carleer Jacqueline - - 2011
During the workshop organized by ILSI/HESI on May 5-6, 2010 on the value of juvenile animal toxicity studies, the implementation of the European Pediatric Regulation and in particular the review process of the nonclinical part of the Pediatric Investigation Plan (PIP) were described. A PIP is intended to outline the ...
Nicolella Daniel P DP Materials Engineering Department, Southwest Research Institute, 6220 Culebra Road, San Antonio, TX 78238-5166, - - 2012
Skeletal fractures associated with bone mass loss are a major clinical problem and economic burden, and lead to significant morbidity and mortality in the ageing population. Clinical image-based measures of bone mass show only moderate correlative strength with bone strength. However, engineering models derived from clinical image data predict bone ...
Henderson M P A - - 2011
OBJECTIVES: This study determined age specific, free thyroxine and thyroid stimulating hormone reference intervals for a pediatric population. METHODS: The data set was partitioned into age groups and the Tukey method was used to identify outliers for removal. The Harris and Boyd algorithm was used to determine if groups could ...
Song Bin - - 2011
Metabolic pathways show the complex interactions among enzymes that transform chemical compounds. The state of a metabolic pathway can be expressed as a vector, which denotes the yield of the compounds or the flux in that pathway at a given time. The steady state is a state that remains unchanged ...
Vanderoost Jef - - 2011
Elastic modulus and strength of trabecular bone are negatively affected by osteoporosis and other metabolic bone diseases. Micro-computed tomography-based beam models have been presented as a fast and accurate way to determine bone competence. However, these models are not accurate for trabecular bone specimens with a high number of plate-like ...
Sharma Manju - - 2011
Initial studies show that 41Ca may be employed as a useful diagnostic bioassay for monitoring metabolic bone disease and its treatment management. The 41Ca-based pharmacokinetic model is developed to assess its feasibility in monitoring bone disease and clinical responsiveness to therapeutic regimens. A four-compartment calcium kinetic model is developed to ...
Dall'ara E - - 2011
While dual energy X-ray absorptiometry (DXA) is considered the gold standard to evaluate fracture risk in vivo, in the present study, the quantitative computed tomography (QCT)-based finite element modeling has been found to provide a quantitative and significantly improved prediction of vertebral strength in vitro. This technique might be used ...
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