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Sonter L J LJ The University of Queensland, Centre for Water in the Minerals Industry, Sustainable Minerals Institute, Brisbane, QLD 4072, Australia. - - 2014
Offsets are a novel conservation tool, yet using them to achieve no net loss of biodiversity is challenging. This is especially true when using conservation offsets (i.e., protected areas) because achieving no net loss requires avoiding equivalent loss. Our objective was to determine if offsetting the impacts of mining achieves ...
Reutlinger Michael M Eidgenössische Technische Hochschule (ETH), Departement Chemie und Angewandte Biowissenschaften, Vladimir-Prelog-Weg 4, 8093 Zürich - - 2014
We present the development and application of a computational molecular de novo design method for obtaining bioactive compounds with desired on- and off-target binding. The approach translates the nature-inspired concept of ant colony optimization to combinatorial building block selection. By relying on publicly available structure-activity data, we developed a predictive ...
Saint-Pierre Louise L 1.Centre de Collaboration Nationale sur les Politiques Publiques et la Santé, Institut National de Santé Publique du Québec, Québec, - - 2014
L'évaluation d'impact sur la santé (EIS) est un courant de pratique qui connaît une popularité croissante partout dans le monde depuis la fin des années 1990. D'abord utilisée dans le cadre des évaluations d'impact environnemental (EIE), elle s'est enrichie des connaissances et des principes portés par le courant des déterminants ...
Zhao Yongxiang - - 2014
We reply to the comment written by Aslam and Güney on our previous paper, Zhao et al. [Opt. Express 19(12), 11605-11614 (2011)]. We maintain that the proposed implementation of the DE algorithm for NIMs optimization in our work is correct, and the mentioned ambiguities in the comment due to the ...
Patel Maulik M Department of Genomics, Xcelris Genomics Research Centre, Ahmadabad, - - 2014
Grapefruit (Citrus pardisi) is a popular citrus fruit that is a cross between a sweet orange and pummelo. This research article focuses on an in silico approach for comparative analysis of C. paradisi green flavedo (GF) and ethylene treated flavedo (ETF) transcriptome data. Our pathway analysis provides comprehensive information of ...
Borchers Svenja - - 2014
During a grasping movement, the maximum grip aperture (MGA) is almost linearly scaled to the dimension of the target along which it is grasped. There is still a surprising uncertainty concerning the influence of the other target dimensions on the MGA. We asked healthy participants to grasp cuboids always along ...
Yu Xiaobing X China Institute of Manufacturing Development, Nanjing University of Information Science & Technology, Nanjing 210044, China ; Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters, Nanjing University of Information Science & Technology, Nanjing 210044, - - 2014
Particle swarm optimization (PSO) and differential evolution (DE) are both efficient and powerful population-based stochastic search techniques for solving optimization problems, which have been widely applied in many scientific and engineering fields. Unfortunately, both of them can easily fly into local optima and lack the ability of jumping out of ...
Chang Zheng Z School of Mathematics, Shandong University, Jinan, Shandong, - - 2014
Transcriptome assembly using RNA-seq data - particularly in non-model organisms has been dramatically improved, but only recently have the pre-assembly procedures, such as sequencing depth and error correction, been studied. Increasing read length is viewed as a crucial condition to further improve transcriptome assembly, but it is unknown whether the ...
Joly Simon S Institut de Recherche en Biologie Végétale, Montreal Botanical Garden, 4101 Sherbrooke East, Montreal, H1X 2B2, - - 2013
Adaptive radiations such as the Darwin finches in the Galapagos or the cichlid fishes from the Eastern African Great Lakes have been a constant source of inspiration for biologists and a stimulus for evolutionary thinking. A central concept behind adaptive radiation is that of evolution by niche shifts, or ecological ...
Bogdanowicz Zbigniew R - - 2013
In this paper, we present a novel optimization algorithm for assigning weapons to targets based on desired kill probabilities. For the given weapons, targets, and desired kill probabilities, our optimization algorithm assigns weapons to targets that satisfy the desired kill probabilities and minimize the overkill. The minimization of overkill assures ...
Zhang You - - 2013
Purpose: To develop a technique to estimate onboard 4D-CBCT using prior information and limited-angle projections for potential 4D target verification of lung radiotherapy.Methods: Each phase of onboard 4D-CBCT is considered as a deformation from one selected phase (prior volume) of the planning 4D-CT. The deformation field maps (DFMs) are solved ...
Brusco Michael J - - 2013
The minimum-diameter partitioning problem (MDPP) seeks to produce compact clusters, as measured by an overall goodness-of-fit measure known as the partition diameter, which represents the maximum dissimilarity between any two objects placed in the same cluster. Complete-linkage hierarchical clustering is perhaps the best-known heuristic method for the MDPP and has ...
Gao Weifeng - - 2013
Multimodal optimization is one of the most challenging tasks for optimization. It requires an algorithm to effectively locate multiple global and local optima, not just single optimum as in a single objective global optimization problem. To address this objective, this paper first investigates a cluster-based differential evolution (DE) for multimodal ...
Hoffmann Errol R - - 2013
Previous research [Hoffmann, E. R. 2011. "Capture of Shrinking Targets." Ergonomics 54 (6): 519-530] reported experiments for capture of shrinking targets where the target decreased in size at a uniform rate. This work extended this research for targets having a shrink-size versus time pattern that of an aircraft receding from ...
Hrotic Steven - - 2013
Van de Vliert associates a greater difference between upper- and lower-class freedoms under less favorable environmental conditions. This pattern is similar to models of the emergence of state-level hierarchies. I argue that Van de Vliert has provided a supportive strand to the history of ancient Near East religion.
Buszman Piotr P - - 2013
This study sought to evaluate vascular drug uptake, distribution and response of second-generation paclitaxel coated balloon (PCB) (Cotavance, MEDRAD Interventional, Indianola, Pennsylvania) and compare it with first-generation technology, containing identical excipient and drug concentration. Original PCB technologies displayed a heterogeneous deposition of crystalline paclitaxel-iopromide inside the balloon folds, whereas second-generation ...
Li Guo-Bo - - 2013
Herein, a combined molecular docking-based and pharmacophore-based target prediction strategy is presented, in which a probabilistic fusion method is suggested for target ranking. Establishment and validation of the combined strategy are described. A target database, termed TargetDB, was firstly constructed, which contains 1105 drug targets. Based on TargetDB, the molecular ...
Pounds Stan - - 2013
Tumors exhibit numerous genomic lesions such as copy number variations, structural variations and sequence variations. It is difficult to determine whether a specific constellation of lesions observed across a cohort of multiple tumors provides statistically significant evidence that the lesions target a set of genes that may be located across ...
Massaro Peter Alexander - - 2013
Purpose: Despite the frequency at which urologists endoscopically estimate lesion size, their accuracy has not been established. Our objectives were to determine the accuracy of cystoscopic and ureteroscopic estimates of lesion size using in vitro models of the urinary tract and to assess potential impacting factors. Materials and Methods: Eleven ...
Turner Brandon M - - 2013
Bayesian estimation has played a pivotal role in the understanding of individual differences. However, for many models in psychology, Bayesian estimation of model parameters can be difficult. One reason for this difficulty is that conventional sampling algorithms, such as Markov chain Monte Carlo (MCMC), can be inefficient and impractical when ...
Hanauer David - - 2013
PURPOSE: We describe an experiment to build a de-identification system for clinical records using the open source MITRE Identification Scrubber Toolkit (MIST). We quantify the human annotation effort needed to produce a system that de-identifies at high accuracy. METHODS: Using two types of clinical records (history and physical notes, and ...
Beccari Andrea R - - 2013
Tools for molecular de novo design are actively sought incorporating sets of chemical rules for fast and efficient identification of structurally new chemotypes endowed with a desired set of biological properties. In this paper, we present LiGen, a suite of programs which can be used sequentially or as stand-alone tools ...
Awunor O A - - 2013
This paper details a practical method for the direct reconstruction of high dose rate (192)Ir source dwell positions in ring applicators using gafchromic film in the treatment planning of brachytherapy cervix patients. It also details the uncertainties associated with such a process. Eight Nucletron interstitial ring applicators-Ø26 mm (×4), Ø30 mm (×3) ...
Abbas Qaisar - - 2013
BACKGROUND/PURPOSE: Computer-aided design (CAD) methods are highly valuable for the analysis of skin lesions using digital dermoscopy due to low rate of diagnostic accuracy of expert dermatologist. In computerized diagnostic methods, automatic border detection is the first and crucial step. METHOD: In this study, a novel unified approach is proposed ...
Zhou Dingyu D Y - - 2013
A model for the combustion of butanol is studied using a recently developed theoretical method for the systematic improvement of the kinetic mechanism. The butanol mechanism includes 1446 reactions, and we demonstrate that it is straightforward and computationally feasible to implement a full global sensitivity analysis incorporating all the reactions. ...
Cai Yiqiao - - 2013
Differential evolution (DE) is a simple and powerful population-based evolutionary algorithm, successfully used in various scientific and engineering fields. Although DE has been studied by many researchers, the neighborhood and direction information is not fully and simultaneously exploited in the designing of DE. In order to alleviate this drawback and ...
Glaister J - - 2013
Melanoma is the most deadly form of skin cancer and it is costly for dermatologists to screen every patient for melanoma. There is a need for a system to assess the risk of melanoma based on dermatological photographs of a skin lesion. However, the presence of illumination variation in the ...
Clarke Kaitlin - - 2013
The fast development of next-generation sequencing technology presents a major computational challenge for data processing and analysis. A fast algorithm, de Bruijn graph has been successfully used for genome DNA de novo assembly; nevertheless, its performance for transcriptome assembly is unclear. In this study, we used both simulated and real ...
Lu Bingxin - - 2013
Transcriptome reconstruction is an important application of RNA-Seq, providing critical information for further analysis of transcriptome. Although RNA-Seq offers the potential to identify the whole picture of transcriptome, it still presents special challenges. To handle these difficulties and reconstruct transcriptome as completely as possible, current computational approaches mainly employ two ...
Khorshid Mohsen - - 2013
We introduce a biophysical model of miRNA-target interaction and infer its parameters from Argonaute 2 cross-linking and immunoprecipitation data. We show that a substantial fraction of human miRNA target sites are noncanonical and that predicted target-site affinity correlates well with the extent of target destabilization. Our model provides a rigorous ...
Pereira Alfredo A - - 2013
De Sousa's comprehensive two-part review of a diversity of contemporary approaches to the study of consciousness is highly welcome. He makes us aware of a proliferation of theoretical and empirical approaches targeting a common theme, but diverging in many ways. He skilfully accomplishes a classification of kinds of approach, identification ...
Chiara Matteo - - 2013
De novo transcriptome characterization from Next Generation Sequencing data has become an important approach in the study of non-model plants. Despite notable advances in the assembly of short reads, the clustering of transcripts into unigene-like (locus-specific) clusters remains a somewhat neglected subject. Indeed, closely related paralogous transcripts are often merged ...
Assaad Wissam - - 2012
During minimally invasive surgical procedures (e.g., needle insertion during interventional radiological procedures), needle-tissue interactions and physiological processes cause tissue deformation. Target displacement is caused by soft-tissue deformation, which results in misplacement of the surgical tool (needle). This study presents a technique to predict target displacement in three-dimensions (3D) by combining ...
Iwama Takanori - - 2012
We study group chase and escape with some fast chasers. In our model chasers look for the nearest target and move to one of the nearest sites in order to catch the target. On the other hand, targets try to escape from the nearest chaser. When a chaser catches a ...
Ferriero Giorgio - - 2012
The aim of this study was to assess the reliability of a smartphone-based application developed for photographic-based goniometry, DrGoniometer (DrG), by comparing its measurement of the knee joint angle with that made by a universal goniometer (UG). Joint goniometry is a common mode of clinical assessment used in many disciplines, ...
Lalpuria Minal - - 2012
AIMS: To investigate the effect of different well sizes and pre-diffusion times at 4°C, on the sensitivity, accuracy and precision of nisin quantification by agar diffusion bioassay. METHODS AND RESULTS: Nisin solution (0.625-125 μg ml(-1) ) was filled in wells (3.5 mm or 7 mm diameter) made on agar plates ...
Wang Hongyuan - - 2012
A modeling and validation method of photometric characteristics of the space target was presented in order to track and identify different satellites effectively. The background radiation characteristics models of the target were built based on blackbody radiation theory. The geometry characteristics of the target were illustrated by the surface equations ...
Li Qian - - 2012
Most existing target acquisition (TA) models neglect the influence of background clutter, which results in inaccurate prediction of TA performance in a complicated environment. In this paper, all the background clutter is first quantitatively characterized by the distribution of edge clutter metric, and its effects on the target detection probability ...
Rudmann Daniel G - - 2012
Adverse toxicologic effects are categorized as chemical-based, on-target, or off-target effects. Chemical-based toxicity is defined as toxicity that is related to the physicochemical characteristics of a compound and its effects on cellular organelles, membranes, and/or metabolic pathways. On-target refers to exaggerated and adverse pharmacologic effects at the target of interest ...
Shrestha Rojan - - 2012
Recent advancements in computational methods for protein-structure prediction have made it possible to generate the high-quality de novo models required for ab initio phasing of crystallographic diffraction data using molecular replacement. Despite those encouraging achievements in ab initio phasing using de novo models, its success is limited only to those ...
Ferrández Oscar O Department of Biomedical Informatics, University of Utah, Salt Lake City, UT 84112, USA. - - 2013
De-identification allows faster and more collaborative clinical research while protecting patient confidentiality. Clinical narrative de-identification is a tedious process that can be alleviated by automated natural language processing methods. The goal of this research is the development of an automated text de-identification system for Veterans Health Administration (VHA) clinical documents. ...
Xu Baomin - - 2012
Fragment assembly is one of the most important problems of sequence assembly. Algorithms for DNA fragment assembly using de Bruijn graph have been widely used. These algorithms require a large amount of memory and running time to build the de Bruijn graph. Another drawback of the conventional de Bruijn approach ...
Pablos Adrián - - 2012
This paper presents and describes new foot fossils from the species Homo antecessor, found in level TD6 of the site of Gran Dolina (Sierra de Atapuerca, Burgos, Spain). These new fossils consist of an almost complete left talus (ATD6-95) and the proximal three-quarters of a right fourth metatarsal (ATD6-124). The ...
Hu Yiping - - 2012
At present, rheumatoid arthritis (RA) is considered a type of autoimmune disease. Its pathology is not certain, and effective drugs with less toxicity have not been established. The establishment and application of animal models are effective methods for RA research, especially using animal models similar to humans. Arthritis is more ...
Zonios George - - 2012
ABSTRACT. Application of low concentration acetic acid solution to various types of human epithelia, in vivo, is a well-established technique for the visual identification of neoplastic and potential precancerous lesions, especially in the cervix. An acetic acid application produces a transient whitening effect associated with the aforementioned lesions (acetowhite effect). ...
Girault Frédéric - - 2012
Effective radium concentration EC(Ra), product of radium concentration and radon emanation, is the source term for radon release into the pore space of rocks and the environment. To measure EC(Ra), we have conducted, over a period of three years, more than 5500 radon-222 accumulation experiments in the laboratory with scintillation ...
Girault Frédéric - - 2012
Effective radium concentration EC(Ra), product of radium concentration and radon emanation, is the source term for radon release into the pore space of rocks and the environment. Over a period of three years, we performed more than 6000 radon-222 accumulation experiments in the laboratory with scintillation flasks and SSNTDs and ...
Lee Chun Ming - - 2012
Tolo Harbour, located in the northeastern part of Hong Kong's New Territories, China, has a high frequency of algal blooms and red tides. An attempt was made to first quantify the submarine groundwater discharge (SGD) into Tolo Harbour using (226)Ra, and then to estimate the nutrient fluxes into the Harbour ...
Bajuri M N - - 2012
The wrist is the most complex joint for virtual three-dimensional simulations, and the complexity is even more pronounced when dealing with skeletal disorders of the joint such, as rheumatoid arthritis (RA). In order to analyse the biomechanical difference between healthy and diseased joints, three-dimensional models of these two wrist conditions ...
Nguyen Christine M - - 2012
Rheumatoid arthritis (RA) is a chronic autoimmune disease that affects approximately 1.5 million people in the US. Tumour necrosis factor (TNF)-α inhibitors have been shown to effectively treat and maintain remission in patients with moderately to severely active RA compared with conventional agents. The high acquisition cost of TNF-α inhibitors prohibits ...
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