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Cooper David K C DK Thomas E. Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA, - - 2014
The pig-to-non-human primate model is the standard choice for in vivo studies of organ and cell xenotransplantation. In 1998, Lambrigts and his colleagues surveyed the entire world literature and reported all experimental studies in this model. With the increasing number of genetically engineered pigs that have become available during the ...
Shaharz Saeid S *Heller School of Social Policy and Management, Brandeis University, Waltham †Tufts University School of Medicine ‡Center for Quality of Care Research §Division of General Medicine, Baystate Medical Center, Springfield ∥Department of Psychology, Brandeis University, Waltham, - - 2014
Selection of International Classification of Diseases (ICD)-based coded information for complex conditions such as severe sepsis is a subjective process and the results are sensitive to the codes selected. We use an innovative data exploration method to guide ICD-based case selection for severe sepsis. Using the Nationwide Inpatient Sample, we ...
Pinsky Michael R MR University of Pittsburgh Medical Center, Critical Care Medicine , Professor of Critical Care Medicine and Bioengineering , 606 Scaife Hall , 3550 Terrace Street , Pittsburgh, Pennsylvania, United States , 15261 , 412-647-5387 , 412-647-8060 ; - - 2014
It is often difficult to accurately predict who, when and why patients develop shock because signs of shock often occur late once organ injury is already present. Three levels of aggregation of information can be used to aid the bedside clinician in this task: analysis of derived parameters of existing ...
Panesi M M University of Illinois at Urbana-Champaign, Urbana, 104 S. Wright street, Champaign, Illinois 61801, - - 2014
A rovibrational collisional model is developed to study the internal energy excitation and dissociation processes behind a strong shock wave in a nitrogen flow. The reaction rate coefficients are obtained from the ab initio database of the NASA Ames Research Center. The master equation is coupled with a one-dimensional flow ...
Srinivasan Sriram Goverapet - - 2014
We present a new DFTB-p3b density functional tight binding model for hydrogen at extremely high pressures and temperatures, which includes a polarizable basis set (p) and a three-body environmentally dependent repulsive potential (3b). We find that use of an extended basis set is necessary under dissociated liquid conditions to account ...
McCaffrey V P VP Department of Chemistry, Albion College, Albion, MI, 49224, USA, - - 2014
Sugars of extraterrestrial origin have been observed in the interstellar medium (ISM), in at least one comet spectrum, and in several carbonaceous chondritic meteorites that have been recovered from the surface of the Earth. The origins of these sugars within the meteorites have been debated. To explore the possibility that ...
Gimenez Philippe P Université de Lyon, Laboratoire de Physiologie de l'Exercice, F-42023 Saint-Etienne, France. Electronic address: - - 2014
Tilting treadmills allow a convenient study of biomechanics during uphill/downhill running, but they are not commonly available and there is even fewer tilting force-measuring treadmill. The aim of the present study was to compare uphill/downhill running on a treadmill (inclination of±8%) with running on a level treadmill using additional backward ...
Shrum Bradly - - 2014
The lack of a reliable scoring system that predicts the development of septic shock and death precludes comparison of disease and/or treatment outcomes in animal models of sepsis. We developed a murine sepsis score (MSS) that evaluates seven clinical variables, and sought to assess its validity and reliability in an ...
Vandendriessche Benjamin B 1Inflammation Research Center, VIB, Ghent, Belgium. 2Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium. 3Department of Intensive Care Medicine, Ghent University Hospital, Ghent, Belgium. 4Department of Management, Technology and Economics, ETH Zurich, Zurich, Switzerland. 5Center for Neurogenomics and Cognitive Research, VU University Amsterdam, Amsterdam, The - - 2014
Early detection and start of appropriate treatment are highly correlated with survival of sepsis and septic shock, but the currently available predictive tools are not sensitive enough to identify patients at risk. Linear (time and frequency domain) and nonlinear (unifractal and multiscale complexity dynamics) measures of beat-to-beat interval variability were ...
Gueudré Thomas T CNRS-Laboratoire de Physique Théorique de l'Ecole Normale Supérieure 24 rue Lhomond, 75005 Paris, - - 2014
We study the energy minimization for a particle in a quadratic well in the presence of short-ranged heavy-tailed disorder, as a toy model for an elastic manifold. The discrete model is shown to be described in the scaling limit by a continuum Poisson process model which captures the three universality ...
Karlsson Martin M CINCH, University of Duisburg-Essen, Schützenbahn 70, 45127 Essen, Germany; University of Oslo, Norway. Electronic address: - - 2014
We study the impact of the 1918 influenza pandemic on short- and medium-term economic performance in Sweden. The pandemic was one of the severest and deadliest pandemics in human history, but it has hitherto received only scant attention in the economic literature - despite representing an unparalleled labour supply shock. ...
Wang Zhen - - 2014
Introduction: To investigate the therapeutic effects of pharmacologic inhibition of dimethylarginine dimethylaminohydrolase1(DDAH-1), an enzyme that metabolizes endogenously produced nitric oxide synthase inhibitors, principally asymmetric dimethylarginine(ADMA). Experimental: This study employs a series of rodent models to evaluate the effectiveness a DDAH1-selective inhibitor(L-257). Short term models involved the development of endotoxaemia using ...
Mueller V V International Food Policy Research Institute, Washington, DC 20006, - - 2014
Human migration attributable to climate events has recently received significant attention from the academic and policy communities (1-2). Quantitative evidence on the relationship between individual, permanent migration and natural disasters is limited (3-9). A 21-year longitudinal survey conducted in rural Pakistan (1991-2012) provides a unique opportunity to understand the relationship ...
Ragno Rino - - 2014
The multi-chaperone heat shock protein (Hsp) 90 complex mediates the maturation and stability of a variety of oncogenic signaling proteins. For this reason, Hsp90 has emerged as a promising target for anti-cancer drug development. Herein, we describe a complete computational procedure for building several 3-D QSAR models used as a ...
Yuan Jia J L212, Faculty of Business Administration, University of Macau, Taipa, Macau, - - 2014
In this research, we explore a unique Chinese peer to peer (P2P) online lottery gambling data (n = 388,123) and examine the rationality of Chinese online lottery gamblers. We show that Chinese online lottery gamblers are irrational in the sense that they are significantly affected by the lottery winning history of others ...
Gatz Rainer R ICU, Herlev Hospital , Herlev , - - 2014
These formulae are erroneous and lead to predictably grossly wrong results. The authors find SIG values of mean -14 mEq/l in the non-survivors' and -10 mEq/l in the survivors' group. ' According to our data the SIG approach does not seem to add further information to usual parameters in acid-base ...
Wong Hector R HR Division of Critical Care Medicine, Cincinnati Children's Hospital Medical Center and Cincinnati Children's Research Foundation, Cincinnati, Ohio, United States of America; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of - - 2014
PERSEVERE is a risk model for estimating mortality probability in pediatric septic shock, using five biomarkers measured within 24 hours of clinical presentation. Here, we derive and test a temporal version of PERSEVERE (tPERSEVERE) that considers biomarker values at the first and third day following presentation to estimate the probability ...
Xiao Hong H 0000-0001-5423-2622 School of Power and Energy, Northwestern Polytechnical University, Xi'an, Shaanxi 710072, - - 2014
Direct simulation Monte Carlo (DSMC) of shock interaction in hypersonic low density flow is developed. Three collision molecular models, including hard sphere (HS), variable hard sphere (VHS), and variable soft sphere (VSS), are employed in the DSMC study. The simulations of double-cone and Edney's type IV hypersonic shock interactions in ...
Zhang Zhongheng Z Department of Critical Care Medicine, Jinhua Municipal Central Hospital, Jinhua Hospital of Zhejiang University, Zhejiang, PR - - 2014
Activated protein C (aPC) plays a pivotal role in modulating a severe inflammatory response and is thought to be beneficial for patients with sepsis. However, several meta-analyses of randomised controlled trials (RCTs) show that aPC is not significantly associated with improved survival in critically ill patients with sepsis. One suggestion ...
Brummitt Charles D CD Department of Mathematics, University of California Davis, Davis, California, United States of America; Complexity Sciences Center, University of California Davis, Davis, California, United States of - - 2014
We explore a model of the interaction between banks and outside investors in which the ability of banks to issue inside money (short-term liabilities believed to be convertible into currency at par) can generate a collapse in asset prices and widespread bank insolvency. The banks and investors share a common ...
Nelson Gerald C GC Environment and Production Technology Division, International Food Policy Research Institute, Washington, DC - - 2013
Agricultural production is sensitive to weather and thus directly affected by climate change. Plausible estimates of these climate change impacts require combined use of climate, crop, and economic models. Results from previous studies vary substantially due to differences in models, scenarios, and data. This paper is part of a collective ...
Kumhof Michael - - 2014
This paper, using a six-region dynamic stochastic general equilibrium model of the world economy, assesses the output and current account implications of permanent oil supply shocks hitting the world economy. For modest-sized shocks and conventional production technologies, the effects are modest. But for larger shocks, for elasticities of substitution that ...
Huy Nguyen Tien - - 2013
Mortality from dengue infection is mostly due to shock. Among dengue patients with shock, approximately 30% have recurrent shock that requires a treatment change. Here, we report development of a clinical rule for use during a patient's first shock episode to predict a recurrent shock episode. The study was conducted ...
Zardad Asma - - 2013
The purpose of this study is to investigate the factors that affect real exchange rate volatility for Pakistan through the co-integration and error correction model over a 30-year time period, i.e. between 1980 and 2010. The study employed the autoregressive conditional heteroskedasticity (ARCH), generalized autoregressive conditional heteroskedasticity (GARCH) and Vector ...
López M Estefanía - - 2013
The removal efficiency (RE) of gas-phase hydrogen sulfide (H), methanol (M) and α-pinene (P) in a biotrickling filter (BTF) was modeled using artificial neural networks (ANNs). The inlet concentrations of H, M, P, unit flow and operation time were used as the model inputs, while the outputs were the RE ...
Moffat Brad - - 2013
The rapid and accurate prediction of the need for massive transfusion in bleeding trauma patients remains a challenge. Various models have been proposed to anticipate massive transfusion with variable success. The current study by Mutschler and colleagues proposes four classes of shock as defined by the Shock Index and examines ...
Xing Bao-Shan - - 2013
The performance of the ANAMMOX process was investigated in two identical laboratory-scale multi- and single-fed upflow anaerobic sludge blanket (UASB) reactors (denoted R1 and R0) at different hydraulic residence times (HRTs) varying from 2.06 to 1.52h and NH4(+)-Ninf concentrations ranging from 70 to 266mgL(-1). The substrate removal efficiencies of both ...
Uzoigwe Chika Edward - - 2013
Septic arthritis is an emergency. In 1999 Kocher et al. identified four clinical criteria to distinguish hip septic arthritis from transient synovitis in children (nonweightbearing, erythrocyte sedimentation rate ≥ 40 mm/L, white blood cell count > 12 × 10(9)/L, temperature > 38.5°C). Subsequent authors evaluating the same criteria produced conflicting ...
Roth Tania L - - 2013
Attachment to an abusive caregiver has wide phylogenetic representation, suggesting that animal models are useful in understanding the neural basis underlying this phenomenon and subsequent behavioral outcomes. We previously developed a rat model, in which we use classical conditioning to parallel learning processes evoked during secure attachment (odor-stroke, with stroke ...
Omi Takahiro - - 2013
Forecasting the aftershock probability has been performed by the authorities to mitigate hazards in the disaster area after a main shock. However, despite the fact that most of large aftershocks occur within a day from the main shock, the operational forecasting has been very difficult during this time-period due to ...
Rasooli M - - 2013
Ventricular Fibrillation (VF) is a cardiac arrhythmia for which the only available treatment option is defibrillation by electrical shock. Existing literature indicates that VF could be the manifestation of different sources controlling the heart with different degrees of organization. In this work we test the hypothesis that the pre-shock waveforms ...
Adhvaryu Achyuta A Assistant Professor, Yale - - 2013
A key prediction of dynamic labor demand models is that firing restrictions attenuate firms' employment responses to economic fluctuations. We provide the first direct test of this prediction using data from India. We exploit the fact that rainfall fluctuations, through their effects on agricultural productivity, generate variation in local demand ...
Lewis Roger J RJ Department of Emergency Medicine, Harbor-UCLA Medical Center, Torrance, CA, - - 2013
Sepsis is the tenth leading cause of death in the United States. Despite extensive research, mortality rates for sepsis have not substantially improved in the last several decades. We describe an innovative phase II clinical trial design for evaluating the addition of L-carnitine to the treatment of vasopressor-dependent septic shock. ...
Fülöp A - - 2013
Massive blood loss leading to hypovolemic shock is still a life-threatening situation. Recently, a great number of investigations have been conducted in order to understand the pathophysiological and immunological changes taking place during shock and to develop treatment strategies. These preclinical trials are based on animal studies. Although a wide ...
Jeger Victor - - 2013
BACKGROUND: The relevance of mitochondrial dysfunction as to pathogenesis of multiple organ dysfunction and failure in sepsis is controversial. This focused review evaluates the evidence for impaired mitochondrial function in sepsis. DESIGN: Review of original studies in experimental sepsis animal models and clinical studies on mitochondrial function in sepsis. In ...
Leal Y - - 2013
Support vector machines (SVMs) are an attractive option for detecting correct and incorrect measurements in realtime continuous glucose monitoring systems (RTCGMSs), because their learning mechanism can introduce a post-processing strategy for imbalanced datasets. The proposed SVM considers the geometric mean to obtain a more balanced performance between sensitivity and specificity. ...
Safarzynska Karolina - - 2013
We propose a model of multi level (group) selection in the presence of climate variability, where environment and culture coevolve. The model describes a population subdivided into groups, each with access to a renewable resource. Individuals employ different harvesting strategies: defectors harvest more resources than cooperators and punishers. In groups ...
Epstein Sharon - - 2013
Sphingolipids are essential components of membranes and important for cellular integrity. The main focus of research in the past years has been to demonstrate their role as second messengers. The yeast Saccharomyces cerevisiae is an excellent model for the study of sphingolipids, because the first steps of this metabolic pathway ...
Revie James A - - 2013
Introduction. The accuracy and clinical applicability of an improved model-based system for tracking hemodynamic changes is assessed in an animal study on septic shock. Methods. This study used cardiovascular measurements recorded during a porcine trial studying the efficacy of large-pore hemofiltration for treating septic shock. Four Pietrain pigs were instrumented ...
Ward Kevin R - - 2013
Survival after severe traumatic shock can be complicated by a number of pathophysiologic processes that ensue after the initial trauma. One of these is trauma-induced coagulopathy (TIC) whose onset may occur before initial fluid resuscitation. The pathogenesis of TIC has not yet been fully elaborated, but evolving evidence appears to ...
Beloncle François - - 2013
This review aimed to answer whether the vasopressors are useful at the early phase of hemorrhagic shock. Data were taken from published experimental studies and clinical trials. Published case reports were discarded. A search of electronic database PubMed was conducted using keywords of hemorrhagic shock, vasopressors, vasoconstrictors, norepinephrine, epinephrine, vasopressin. ...
Kaushik Rahul - - 2013
We analyse time series of CDS spreads for a set of major US and European institutions in a period overlapping the recent financial crisis. We extend the existing methodology of [Formula: see text]-drawdowns to the one of joint[Formula: see text]-drawups, in order to estimate the conditional probabilities of spike-like co-movements ...
Loepfe Lasse - - 2013
The 2007-2008 financial crisis solidified the consensus among policymakers that a macro-prudential approach to regulation and supervision should be adopted. The currently preferred policy option is the regulation of capital requirements, with the main focus on combating procyclicality and on identifying the banks that have a high systemic importance, those ...
Sucker C - - 2012
Objectives; In gram-positive sepsis, lipoteichoic acid (LTA) can induce alterations of haemostasis, potentially leading to disseminated intravascular coagulation. Patients and Methods; Here, we demonstrate the effects of LTA on haemostasis in an in vitro model of gram-positive sepsis based on rotation thromboelastrography (ROTEM). Results; In this model, LTA leads to ...
Bonnet Marion S - - 2012
Deoxynivalenol (DON), mainly produced by Fusarium fungi, and also commonly called vomitoxin, is a trichothecene mycotoxin. It is one of the most abundant trichothecenes which contaminate cereals consumed by farm animals and humans. The extent of cereal contamination is strongly associated with rainfall and moisture at the time of flowering ...
Jensen Christian Gaden - - 2012
Studies of synchronous physiological responses to startle stimuli between monozygotic twins and other paired subjects have suffered from methodological flaws such as post-hoc specifications of "connectedness" criteria. The mechanisms that affect any such connectedness are unknown. With the logistic and financial support of a television company, we conducted a methodological ...
Goldhaber-Fiebert Jeremy D JD Stanford Health Policy, Stanford University, 117 Encina Commons, Stanford, CA 94305-6019, USA. - - 2012
The objective was to demonstrate decision-analytic modeling in support of Child Welfare policymakers considering implementing evidence-based interventions. Outcomes included permanency (e.g., adoptions) and stability (e.g., foster placement changes). Analyses of a randomized trial of KEEP-a foster parenting intervention-and NSCAW-1 estimated placement change rates and KEEP's effects. A microsimulation model generalized ...
Freeman Jacob - - 2012
This paper presents a stylized bioeconomic model of hunter-gatherer foraging effort designed to study the process of intensification on open-access resources. A critical insight derived from the model is that the very success of an adaptation at the level of an individual forager group can create system-level vulnerabilities that subsequently ...
Wong Hector R - - 2012
ABSTRACT: INTRODUCTION: The intrinsic heterogeneity of clinical septic shock is a major challenge. For clinical trials, individual patient management, and quality improvement efforts, it is unclear which patients are least likely to survive and thus benefit from alternative treatment approaches. A robust risk stratification tool would greatly aid decision-making. The ...
Roberts J C - - 2012
A human head finite element model (HHFEM) was developed to study the effects of a blast to the head. To study both the kinetic and kinematic effects of a blast wave, the HHFEM was attached to a finite element model of a Hybrid III ATD neck. A physical human head ...
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