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Yang Jian-Wei - - 2014
Objective: The purpose of this study was to describe the population pharmacokinetics (PK) of tacrolimus (TAC) in 52 Chinese pediatric patients early after liver transplantation. Methods: Details of drug dose, sampling times and concentrations were collected retrospectively from routine therapeutic drug monitoring data from the first day after surgery. A ...
Yu Guo G Medical Research Center, Subei People's Hospital, Yangzhou University, No. 98 Nantong West Road, Yangzhou, 225001, - - 2014
Physiologically based pharmacokinetic (PBPK) modeling holds great promise for anticipating the quantitative changes of pharmacokinetics in pediatric populations relative to adults, which has served as a useful tool in regulatory reviews. Although the availability of specialized software for PBPK modeling has facilitated the widespread applications of this approach in regulatory ...
Condren Michelle M Department of Pharmacy, Clinical and Administrative Sciences-Tulsa, University of Oklahoma College of Pharmacy and Department of Pediatrics, University of Oklahoma School of Community Medicine, Tulsa, Okla. Electronic address: - - 2014
To measure the difference in prescribing error rates between 2 clinics, 1 with a system in place to reduce errors and 1 with no such system; to determine variables that affect the likelihood of prescription errors. This was a retrospective study at 2 university-based general pediatric clinics utilizing the same ...
Bailey L Charles LC Department of Pediatrics, Children's Hospital of Philadelphia and Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pa. Electronic address: - - 2014
Electronic health records (EHR) and registries play a central role in health care and provide access to detailed clinical information at the individual, institutional, and population level. Use of these data for clinical quality/performance improvement and cost management has been a focus of policy initiatives over the past decade. The ...
Rahim Najia N Department of Pharmaceutics, Dow College of Pharmacy, Dow University of Health Sciences, Karachi, Sindh, - - 2014
Fast Disintegrating Tablets (FDTs) is a rapidly growing dosage form preferred for special population (pediatric, geriatric and psychotic patients). It is also developed with the aim of improving bioavailability and patient compliance. During the present study, cefadroxil fast disintegrating tablets formulations (n=9) were designed and optimized by central composite design ...
Long-Boyle Janel J 1Department of Clinical Pharmacy, University of California San Francisco, San Francisco, California 2Department of Bioengineering and Therapeutics, University of California San Francisco, San Francisco, California 3Department of Pharmacy, Memorial Sloan Kettering Cancer Center, New York, New York 4Department of Pharmacy, UCSF Benioff Children's Hospital, University of California San Francisco, San Francisco, California 5Department of Laboratory Medicine, UCSF Medical Center, University of California San Francisco, San Francisco, California 6Department of Pediatrics, Floating Hospital for Children, Tufts University, Boston, Massachusetts 7Department of Pediatrics, UCSF Benioff Children's Hospital, University of California San Francisco, San Francisco, - - 2014
Population pharmacokinetic (PK) studies of busulfan in children have shown that individualized model-based algorithms provide improved targeted busulfan therapy when compared to conventional dosing. The adoption of population PK models into routine clinical practice has been hampered by the tendency of pharmacologists to develop complex models too impractical for clinicians ...
Stockwell David Christopher DC From the *Division of Critical Care Medicine, Department of Pediatrics, School of Medicine, The George Washington University, Washington, DC; †Center for Quality and Improvement Science, Children's National Medical Center, Washington, DC; ‡Children's Hospital Association, Overland Park, KS; §Department of Infectious Disease, School of Medicine, University of Utah, Salt Lake City, UT; Pascal Metrics, Washington, DC; ¶Division of Biomedical Informatics, Division of Hospital Medicine, Department of Pediatrics, University of Cincinnati, Cincinnati, OH; #James M. Anderson Center for Health Systems Excellence, Cincinnati Children's Hospital Medical Center, Cincinnati, OH; **Medical Directors Office, Quality and Safety, Great Ormond Street Hospital NHS Foundation Trust, London, England; ††Departments of Paediatrics and Medicine and Centre for Patient Safety, University of Toronto, Toronto, ON; ‡‡Department of Pediatrics, School of Medicine, University of Colorado, Aurora, CO; §§Research Institute, and Department of Quality and Patient Safety, Children's Hospital Colorado, Aurora, CO; ¶¶Department of Anesthesia and Critical Care Medicine, and ##Department of Quality, Children's Hospital Central California, Madera, CA; ***Division of General Pediatrics, Department of Pediatrics, School of Medicine, Stanford University palo Alto, CA; and †††Center for Quality and Clinical Effectiveness, Lucile Packard Children's Hospital, Palo Alto, - - 2014
To have impact on reducing harm in pediatric inpatients, an efficient and reliable process for harm detection is needed. This work describes the first step toward the development of a pediatric all-cause harm measurement tool by recognized experts in the field. An international group of leaders in pediatric patient safety ...
Bouleux Guillaume - - 2014
When epidemics occur, such as is the case for Bronchiolitis in pediatric ED, the patient flow in the ED incontestably increases and can lead to crowding. We bypassed this difficulty of forecasting patient flow with aggregated weekly or monthly data, by tackling the problem from a different point of view. ...
Helle Tina T Department of Occupational Therapy, University College of Northern Jutland in Aalborg, - - 2014
Abstract This study addresses development of a content-valid cross-Nordic version of the Housing Enabler and investigation of its inter-rater reliability when used in occupational therapy rating situations, involving occupational therapists, clients, and their home environments. The instrument was translated from the original Swedish version of the Housing Enabler, and adapted ...
Maro Judith C JC Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, 133 Brookline Avenue, 6th Floor, Boston, MA, 02215, USA, - - 2014
Postmarket surveillance of the comparative safety and efficacy of orphan therapeutics is challenging, particularly when multiple therapeutics are licensed for the same orphan indication. To make best use of product-specific registry data collected to fulfill regulatory requirements, we propose the creation of a distributed electronic health data network among registries. ...
Carter Hannah E HE NHMRC Clinical Trials Centre, University of Sydney, Camperdown, Australia. Electronic address: - - 2014
Intensity modulated radiation therapy (IMRT) is a radiation therapy technology that facilitates the delivery of an improved dose distribution with less dose to surrounding critical structures. This study estimates the longer term effectiveness and cost-effectiveness of IMRT in patients post radical prostatectomy. A Markov decision model was developed to calculate ...
Dalgleish Tracy L TL Greenbelt Family Health Team, Ottawa Couple and Family - - 2014
Emotionally focused couple therapy (EFT) is an empirically validated approach to couple therapy that uses attachment theory to understand the needs and emotions of romantic partners. EFT is recognized as one of the most effective approaches to couple therapy, but to guide therapists in their use of EFT, a theoretically ...
Schade Lori C LC Brigham Young - - 2014
This longitudinal dyadic clinical process study used coded data from eleven couples to determine the influence of therapist warmth behaviors on couples' warmth behaviors over time in therapy. A mixed effects model was used to examine within- and between-individual variability. Men and women were modeled separately. A series of two-level ...
Zupan Laure L Laboratoire d'Écologie Alpine, UMR CNRS 5553, Université Joseph Fourier, Grenoble Cedex 9, - - 2014
We investigate patterns of phylogenetic diversity in relation to species diversity for European birds, mammals and amphibians, to evaluate their congruence and highlight areas of particular evolutionary history. We estimate the extent to which the European network of protected areas (PAs) network retains interesting evolutionary history areas for the three ...
Dörr Claudia S CS Mannheim Institute of Public Health, Social and Preventive Medicine (Dörr, Bock, Fischer, De Bock), Medical Faculty Mannheim, Heidelberg University, Mannheim, - - 2014
Previous work suggests that many context-level characteristics of preschools are associated with increased physical activity (PA) in children. To facilitate assessment of preschools' friendliness toward PA, an item battery as well as comprehensive and short rating scores were developed based on mixed methods with validity and reliability tested. Organizational and ...
Santibáñez Pablo P Radiotherapy Department, Vancouver Centre, British Columbia Cancer Agency, Vancouver, British Columbia, - - 2014
To develop a framework with which to evaluate locations of radiation therapy (RT) centers in a region based on geographic access. Patient records were obtained for all external beam radiation therapy started in 2011 for the province of British Columbia, Canada. Two metrics of geographic access were defined. The primary ...
Sadnicka Anna A Sobell Department of Motor Neuroscience and Movement Disorders, University College London, London, - - 2014
Much attention has focused on the hypothesis that there is enhanced plasticity of sensorimotor circuits in patients with dystonia. A common experimental method to assess plasticity in dystonia research is paired associative stimulation (PAS). Excessive, nonfocal effects of PAS were observed in early studies of dystonia; however, these large effects ...
Latt L D LD Department of Orthopaedic Surgery, University of Arizona, 1609 N. Warren Ave., P.O. Box 245064, Tucson, AZ, 85724, USA, - - 2014
Despite the high prevalence of trochlear dysplasia among patients with patellar instability, it is not well studied and is infrequently addressed surgically. The lack of a validated cadaveric model of trochlear dysplasia may be a contributing factor. The goal of this study was to develop a simple, reproducible, and realistic ...
Mostowy Rafal R Department of Infectious Disease Epidemiology, Imperial College London, St Mary's Campus, London, United - - 2014
The bacterium Streptococcus pneumoniae (pneumococcus) is one of the most important human bacterial pathogens, and a leading cause of morbidity and mortality worldwide. The pneumococcus is also known for undergoing extensive homologous recombination via transformation with exogenous DNA. It has been shown that recombination has a major impact on the ...
Hansen David M DM 1Department of Psychology and Research in Education, The University of Kansas, Lawrence, KS; 2Department of Health, Physical Education & Recreation, Augustana College, Sioux Falls, SD; 3Internal Medicine, Cardiovascular Research Institute, Center for Physical Activity and Weight Management, The University of Kansas Medical Center, Kansas City, KS; 4Institute for Measurement, Methodology, Analysis, and Policy, The Texas Tech University, Lubbock, - - 2014
A growing research base suggests the benefits of physical activity (PA) and aerobic fitness for children extend beyond overall health/well-being to include academic achievement (AA). The majority of research studies on relations of PA and fitness with AA have utilized linear-only analytic approaches, thereby precluding the possibility that PA and ...
Cerin Ester E 1Centre of Physical Activity and Nutrition Research, School of Exercise and Nutrition Sciences, Deakin University, Burwood, Victoria, Australia; 2Institute of Human Performance, The University of Hong Kong, Hong Kong, China; 3Department of Family and Preventive Medicine, University of California, San Diego, CA; 4Department of Movement and Sport Sciences, Ghent University, Ghent, Belgium; 5Auckland University of Technology, Human Potential Centre, Auckland, New Zealand; 6Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Denmark; 7Baker IDI Heart and Diabetes Institute, Melbourne, Australia; 8Centre for Research & Action in Public Health, Canberra University, Canberra, ACT, Australia; 9Department of Physical Education, Federal University of Parana, Curitiba, Brazil; 10Institute of Active Lifestyle, Faculty of Physical Culture, Palacký University, Olomouc, Czech Republic; 11Department of Health Sciences, Public University of Navarra, Pamplona, Navarra, Spain; 12Center for Nutrition and Health Research, National Institute of Public Health, Cuernavaca, Morelos, Mexico; 13Stanford Prevention Research Center, Stanford University School of Medicine, Palo Alto, CA; 14Nutrition and Health Sciences Program, Graduate Division of Biological and Biomedical Sciences, Emory University, Atlanta, GA; 15Universidad de los Andes, Department of Public Health, School of Medicine, Bogotá, - - 2014
Environmental changes are potentially effective population-level physical activity (PA) promotion strategies. However, robust multi-site evidence to guide international action for developing activity-supportive environments is lacking. We estimated pooled associations of perceived environmental attributes with objectively-measured PA outcomes; between-site differences in such associations; and, the extent to which perceived environmental attributes ...
Roth Anthony D AD a Research Department of Clinical, Educational and Health Psychology , University College London , London , - - 2014
Abstract Practitioners transporting psychological therapies from a research context to clinical settings need to know what competences they should demonstrate to maintain congruence with the evidence base. This study explores the validity of a suite of competence frameworks for cognitive behavior therapy (CBT), humanistic, and psychodynamic therapies developed to aid ...
Williams Paul P University of Newcastle, Callaghan, New South Wales, - - 2014
Simultaneously presented signals may be processed in serial or in parallel. One potentially valuable indicator of a system's characteristics may be the appearance of multimodality in the response time (RT) distributions. It is known that standard serial models can predict multimodal RT distributions, but it is unknown whether multimodality is ...
Wenke Rachel R Gold Coast Hospital and Health Service , Gold Coast , - - 2014
The current study explored the clinical feasibility and costs of embedding three different intensive service delivery models for aphasia treatment (computer, group therapy, and therapy with a speech pathology therapy assistant) within three sub-acute facilities. The study employed a two cohort comparison design, with the first cohort (n = 22) ...
Zandbelt Bram B Center for Integrative and Cognitive Neuroscience, Vanderbilt Vision Research Center, Department of Psychology, Vanderbilt University, Nashville, TN - - 2014
Decision-making is explained by psychologists through stochastic accumulator models and by neurophysiologists through the activity of neurons believed to instantiate these models. We investigated an overlooked scaling problem: How does a response time (RT) that can be explained by a single model accumulator arise from numerous, redundant accumulator neurons, each ...
Viennet C C PhD, Research Engineer, Engineering and Cutaneous Biology Laboratory, UMR 1098, University of Franche-Comte, - - 2014
Objective: To describe an in vitro fibrin clot model that could reliably assess the fibrinolytic activity of enzymatic debriding agents for wound care application. Method: A model of a fibrin clot was reconstructed in vitro by mixture of human fibrinogen and (alpha)-thrombin supplemented with factor XIII. These clots were then ...
Thelwell Craig C Biotherapeutics, Haemostasis Section, National Institute for Biological Standards and Control, South Mimms, United - - 2014
Thrombolytic drugs are used for the treatment of thrombotic disorders such as acute myocardial infarction, acute ischemic stroke, and pulmonary embolism. Biological standards are used for potency assignment to the range of fibrinolytic proteins used in thrombolytic therapy. The World Health Organization (WHO) International Standards are primary reference materials, calibrated ...
Salerno Jonathan D JD Graduate Group in Ecology, University of California, Davis, One Shields Avenue, Davis, CA 95616, U.S.A.. - - 2014
A recent discussion debates the extent of human in-migration around protected areas (PAs) in the tropics. One proposed argument is that rural migrants move to bordering areas to access conservation outreach benefits. A counter proposal maintains that PAs have largely negative effects on local populations and that outreach initiatives even ...
Busk Peter K - - 2014
MicroRNAs are small but biologically important RNA molecules. Although different methods can be used for quantification of microRNAs, quantitative PCR is regarded as the reference that is used to validate other methods. Several commercial qPCR assays are available but they often come at a high price and the sequences of ...
McDowell Jillian Marie JM Prohealth Physiotherapy, 124 Kelvin St, Invercargill 9810, New Zealand. Electronic address: - - 2014
Quality technique documentation is integral to the practice of manual therapy, ensuring uniform application and reproducibility of treatment. Manual therapy techniques are described by annotations utilizing a range of acronyms, abbreviations and universal terminology based on biomechanical and anatomical concepts. The various combinations of therapist and patient generated forces utilized ...
Sanders Taren T University of Western Sydney, School of Science and Health, Penrith, - - 2014
Accurate, objective measurement is important for understanding adolescents' physical activity (PA) behaviour. When using accelerometry to objectively measure PA, a decision must be made regarding how frequently data is recorded (i.e., epoch length). The purpose of this study was to examine i) PA bout length, and ii) the effect of ...
McCallum Jamie W JW School of Biological Sciences, University of Bristol, Bristol, United Kingdom; Conservation Programmes, Zoological Society of London, Regents Park, London, United - - 2014
Several thousand terrestrial protected areas (PAs) lie on international boundaries. Because international boundaries can be focal points for trade, illegal activity and development, such PAs can be vulnerable to a range of anthropogenic threats. There is an increasing trend towards the erection of international boundary infrastructure (including fences, barriers and ...
Wegmann Martin M Department of Remote Sensing, Remote Sensing and Biodiversity Research Group, University of Wuerzburg, , Wuerzburg, - - 2014
The African protected area (PA) network has the potential to act as a set of functionally interconnected patches that conserve meta-populations of mammal species, but individual PAs are vulnerable to habitat change which may disrupt connectivity and increase extinction risk. Individual PAs have different roles in maintaining connectivity, depending on ...
Lindsey Peter A PA Panthera, New York, New York, United States of America; Mammal Research Institute, Department of Zoology and Entomology, University of Pretoria, Pretoria, Gauteng, South - - 2014
Many African protected areas (PAs) are not functioning effectively. We reviewed the performance of Zambia's PA network and provide insights into how their effectiveness might be improved. Zambia's PAs are under-performing in ecological, economic and social terms. Reasons include: a) rapidly expanding human populations, poverty and open-access systems in Game ...
Olofsson Jonas K JK Gösta Ekman Laboratory, Department of Psychology, Stockholm University Stockholm, Sweden ; Swedish Collegium of Advanced Study Uppsala, - - 2014
The timing of olfactory behavioral decisions may provide an important source of information about how the human olfactory-perceptual system is organized. This review integrates results from olfactory response-time (RT) measurements from a perspective of mental chronometry. Based on these findings, a new cascade model of human olfaction is presented. Results ...
Arbour-Nicitopoulos Kelly P KP Faculty of Kinesiology and Physical Education, University of Toronto , Toronto, ON , Canada ; Bloorview Research Institute , Toronto, ON , - - 2014
Individuals with schizophrenia tend to have high levels of cardiovascular disease and lower physical activity (PA) levels than the general population. Research is urgently required in developing evidence-based behavioral interventions for increasing PA in this population. One model that has been increasingly used to understand the mechanisms underlying PA is ...
Yang Xiaoxia X National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas, United States of - - 2014
The widespread usage of methylphenidate (MPH) in the pediatric population has received considerable attention due to its potential effect on child development. For the first time a physiologically based pharmacokinetic (PBPK) model has been developed in juvenile and adult humans and nonhuman primates to quantitatively evaluate species- and age-dependent enantiomer ...
Bai Ying Y Department of Computer Science and Engineering, Johnson C. Smith University, NC 28216, - - 2014
Many techniques and research models on calculating and reducing the nuclear radiation dose on pediatric nuclear medicine procedure have been developed and reported in recent years. However, most those models either utilized simple shapes to present the organs or used more realistic models to estimate the nuclear dose applied on ...
Brodin N Patrik - - 2013
To present a novel tool that allows quantitative estimation and visualization of the risk of various relevant normal tissue endpoints to aid in treatment plan comparison and clinical decision making in radiation therapy (RT) planning for Hodgkin lymphoma (HL). A decision-support tool for risk-based, individualized treatment plan comparison is presented. ...
Plotnikoff Ronald C - - 2013
Theory-based interventions to promote physical activity (PA) are more effective than atheoretical approaches; however, the comparative utility of theoretical models is rarely tested in longitudinal designs with multiple time points. Further, there is limited research that has simultaneously tested social-cognitive models with self-report and objective PA measures. The primary aim ...
Guo Qian Q Department of Mathematics, Shanghai Normal University, 100 Guilin Road, Shanghai 200234, - - 2013
We propose an algorithm based on cross-entropy to determine parameters of a piecewise linear model, which describes intermittent androgen suppression therapy for prostate cancer. By comparing with clinical data, the parameter estimation for the switched system shows good fitting accuracy and efficiency. We further optimize switching time points for the ...
Boterhoven De Haan Katrina L - - 2013
Abstract Objective: Debates continue over shared factors in therapy processes between different theoretical orientations. By seeking the opinions of practicing clinicians, this study aimed to elucidate the similarities and differences between cognitive-behavioural (CBT), psychodynamic (PDT), and schema therapy (ST) approaches. Method: Forty-eight practitioners aligning with one of the three approaches ...
Wilhelm Stanis Sonja A - - 2013
Examine macro-level associations of youth physical activity (PA) and weight status with availability of outdoor recreation resources (i.e., parkland, forestland, natural preserves, nonmotorized trails, and motorized trails) across counties in Minnesota. Hierarchical regression models examined if availability of recreation resources significantly improved prediction of PA and weight status of 9th ...
Armitage James Michael - - 2013
The main objective of this study was to evaluate the performance and demonstrate the utility of a fugacity-based model of passive air samplers (PAS) designed to simulate the uptake of neutral organic chemicals under variable temperatures, external wind speeds and ambient air concentrations. The model (PAS-SIM) simulates the transport of ...
Mailhot Vega Raymond B - - 2013
Proton therapy has been a hotly contested issue in both scientific publications and lay media. Proponents cite the modality's ability to spare healthy tissue, but critics claim the benefit gained from its use does not validate its cost compared with photon therapy. The objective of this study was to evaluate ...
Hong Li Yan - - 2013
Pyrrolizidine alkaloids (PAs) are a group of heterocyclic phytotoxins present in a wide range of plants. The consumption of PA-containing medicinal herbs or PA-contaminated foodstuffs has long been reported to cause human hepatotoxicity. However, the degrees of hepatotoxicity of different PAs are unknown, which makes it difficult to determine a ...
Pérez-Prieto L A - - 2013
Daily pasture allowance (PA) is defined as the product of pregrazing pasture mass and offered area, and is the major grazing management factor determining pasture utilization per unit area and daily performance of grazing dairy cows. The objective of the present study was to perform a meta-analysis reviewing the effect ...
Beer Andrew - - 2013
Trait Negative Affect (NA) and Positive Affect (PA) are strongly associated with Neuroticism and Extraversion, respectively. Nevertheless, measures of the former tend to show substantially weaker self-other agreement-and stronger assumed similarity correlations-than scales assessing the latter. The current study separated the effects of item content versus format on agreement and ...
Guerbois Chloe - - 2013
Increase in human settlements at the edge of protected areas (PAs) is perceived as a major threat to conservation of biodiversity. Although it is crucial to integrate the interests of surrounding communities into PA management, key drivers of changes in local populations and the effects of conservation on local livelihoods ...
Xiao Yanyu - - 2013
The 2009 influenza A (H1N1) pandemic was mild by historical standards, but was more severe in isolated Canadian Indigenous communities. Oseltamivir was used aggressively for outbreak control in an isolated northern Ontario First Nations community. We used mathematical modeling to quantify the impact of antiviral therapy on the course of ...
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