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Ojeda David   2014
Mathematical models of the coronary circulation have been shown to provide useful information for the analysis of intracoronary blood flow and pressure measurements acquired during coronary artery bypass graft (CABG) surgery. Although some efforts towards the patientspecific estimation of model parameters have been presented in this context, they are based ...


Irving John J Ninewells Hospital, Dundee UK.   2014
Chronic total occlusion (CTO) pathophysiology has been described in a few, small studies using post mortem histology, and more recently, in vivo intravascular ultrasound (IVUS) to analyse the constituents of occluded segments. Recent improvements in equipment and techniques have revealed new insights into physical characteristics of occluded coronaries, which in ...


Kobayashi Donald R DR Pacific Islands Fisheries Science Center, National Marine Fisheries Service, National Oceanic and Atmospheric Administration, Honolulu, Hawaii, United States of   2014
The movement of juvenile loggerhead turtles (n = 42) outfitted with satellite tags and released in oceanic waters off New Caledonia was examined and compared with ocean circulation data. Merging of the daily turtle movement data with drifter buoy movements, OSCAR (Ocean Surface Current Analyses  Real time) circulation data, and three ...


Gabriela FernándezViejo FV Department of Geology, University of Oviedo. C/Jesús Arias de Velasco, s/n, 33005 Oviedo   2014
The Cantabrian Fault is a longlived crustal fault, 320 km long on land and extending more than 150 km seawards within the Bay of Biscay, which separates different geodynamic domains. Due to its subvertical dip and late strike slip movement is poorly evidenced in the shelf and it has been traditionally mapped ...


The MMPI2RF Personality Psychopathology Five (PSY5RF) Scales: Development and Validity Research.
Harkness Allan R   2013
This article describes the development, internal psychometric, and external validation studies on scales designed to measure the Personality Psychopathology Five (PSY5) from MMPI2 Restructured Form (MMPI2RF) items. Diverse and comprehensive data sets, representing various clinical and nonclinical populations, were classified into development and validation research samples. Item selection, retention, and ...


Ojeda David   2013
Computational models can help understand the hemodynamics of the coronary circulation, which is of the upmost importance to help clinicians before, during and after a coronary artery bypass graft surgery. In this paper, we propose a multiobjective optimization method for parameter estimation of a computational model representing the coronary circulation ...


Sahler Christopher S   2013
Objective. To describe a longitudinal ultrasoundguided inplane approach for injection into the first metatarsophalangeal (MTP) joint and assess its accuracy in a cadaveric model. Design. A prospective anatomical cadaver study model was used. A total of 10 first MTP joints using the described technique were injected with 0.5 mL of ...


Moustafa Ahmed A AA Department of Veterans Affairs, New Jersey Health Care System, East Orange, NJ, USA.   2013
A recurrentnetwork model provides a unified account of the hippocampal region in mediating the representation of temporal information in classical eyeblink conditioning. Much empirical research is consistent with a general conclusion that delay conditioning (in which the conditioned stimulus CS and unconditioned stimulus US overlap and coterminate) is independent of ...


Eilola Kari   2012
We quantified horizontal transport patterns and the net exchange of nutrients between shallow regions and the open sea in the Baltic proper. A coupled biogeochemicalphysical circulation model was used for transient simulations 19612100. The model was driven by regional downscaling of the IPCC climate change scenario A1B from two global ...


Santos Marta   2012
The fish liver has been the main subject of the biomonitoring and laboratory studies dealing with environmental carcinogenesis. The foci of cellular alterations are accepted preneoplastic hepatic lesions, and histopathology is the primary tool for their characterization. Despite its potential, using stereology to study quantitatively nuclear features of those lesions ...


Arnio Ashley N   2012
Foreclosure rates in America reached unprecedented levels during the last half of the 2000s, and many observers have speculated that elevated crime rates were one of the probable negative collateral consequences of this trend. We examine this issue with a comprehensive countylevel analysis of the role of foreclosure in shaping ...


SohleniusSternbeck AnnaKarin   2012
Systematic underprediction of clearance is frequently associated with in vitro kinetic data when extrapolated using physiological scaling factors, appropriate binding parameters and the wellstirred model. The present study describes a method of removing this systematic bias through application of empirical correction factors derived from regression analyses applied to the in ...


Albaugh Daniel R   2012
The current studies assessed the utility of freshly plated hepatocytes, cryopreserved plated hepatocytes, and cryopreserved plated HepaRG cells for the estimation of inactivation parameters k(inact) and K(I) for CYP3A. This was achieved using a subset of CYP3A timedependent inhibitors (fluoxetine, verapamil, clarithromycin, troleandomycin, and mibefradil) representing a range of potencies. ...


Buford William L WL Jr Department of Orthopedic Surgery and Rehabilitation, University of Texas Medical Branch, Galveston, TX 77555, USA.   2012
In this project 3D interactive models of twelve cadaver elbows are developed using the author's kinematic simulation software. The effective flexionextension axes for each specimen's model are iteratively defined based upon congruent joint motion and individual limits in rangeofmotion. Origins and insertions of both parts of the medial collateral ligament ...


Kosmidou Vasiliki E   2011
Sign language (SL) forms an important communication canal for the deaf. In this paper, enhanced SL recognition, by relating the individual way of signing with the signer's level of deafness (LoD) through a novel hybrid adaptive weighting (HAW) process applied to surface electromyogram and 3D accelerometer data, is proposed. Using ...


Edge Christopher B   2011
The majority of studies on the toxicity of glyphosatebased herbicides to amphibians have focused on larval life stages exposed in aqueous media. However, adult and juvenile amphibians may also be exposed directly or indirectly to herbicides. The potential for such exposures is of particular interest in the littoral zone surrounding ...


Awkerman Jill A   2011
Ecological risk assessments rarely evaluate indirect pesticide effects. Pesticides causing no direct mortality in wildlife can still reduce prey availability, resulting in a lower reproductive rate or poor juvenile condition. Few studies have examined these consequences at the population level. We use a fouryear dataset from a forest ecosystem where ...


Janies Daniel A   2011
Reconstruction of the phylogeny of the five extant classes of the phylum Echinodermata has proven difficult. Results concerning higherlevel taxonomic relationships among echinoderms are sensitive to the choice of analytical parameters and methods. Moreover, the proposal of a putative sixth class based on a small enigmatic discshaped echinoderm, Xyloplax, from ...


Sun Liuquan   2011
In this article, we propose a class of BoxCox transformation models for recurrent event data, which includes the proportional means models as special cases. The new model offers great flexibility in formulating the effects of covariates on the mean functions of counting processes while leaving the stochastic structure completely unspecified. ...


Goldstein Naomi E Sevin   2011
This article describes the psychometric properties of the Miranda Rights Comprehension Instruments, the revised version of Grisso's Miranda instruments. The original instruments demonstrated good reliability and validity in a normative sample. The revised instruments updated the content of the original instruments and were administered to a sample of 183 youth ...


Liu Dandan D Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 481092029, USA.   2011
Summary In this article, we propose a positive stable shared frailty Cox model for clustered failure time data where the frailty distribution varies with clusterlevel covariates. The proposed model accounts for covariatedependent intracluster correlation and permits both conditional and marginal inferences. We obtain marginal inference directly from a marginal model, ...


Débarre Florence   2011
Abstract Since their first formulations about half a century ago, the soft and hard selection models have become classical frameworks to study selection in subdivided populations. These models differ in the timing of density regulation and represent two extreme types of selection: density and frequencydependent selection (soft) and density and ...


Alemayehu Demissie   2011
Covariate adjustment helps to minimize bias by eliminating the influence of one variable on another and generally improves precision of estimators in comparative studies. However, despite considerable discussion in the literature on the topic, there is continued controversy and misunderstanding about its valid use and impact in medical research. We ...


Huang Yangxin   2011
Summary In recent years, nonlinear mixedeffects (NLME) models have been proposed for modeling complex longitudinal data. Covariates are usually introduced in the models to partially explain intersubject variations. However, one often assumes that both model random error and random effects are normally distributed, which may not always give reliable results ...


Iturria Stephen J   2011
A method is proposed for block randomization of treatments to experimental units that can accommodate both multiple quantitative blocking variables and unbalanced designs. Hierarchical clustering in conjunction with leaforder optimization is used to block experimental units in multivariate space. The method is illustrated in the context of a diabetic mouse ...


Yi G Y   2011
Summary Longitudinal data arise frequently in medical studies and it is common practice to analyze such data with generalized linear mixed models. Such models enable us to account for various types of heterogeneity, including between and withinsubjects ones. Inferential procedures complicate dramatically when missing observations or measurement error arise. In ...


Takizawa Tadashi   2011
When predator biodiversity strengthens herbivore suppression, the pattern generally is attributed to interspecific complementarity. However, the relaxation of intraspecific interference within diverse communities has received less attention as an underlying factor, and most experiments to date span much less than one predator generation. Here, working with a community of aphid ...


Nakazawa Takefumi   2011
It has been suggested that when juveniles and adults use different resources or habitats, alternative stable states (ASS) may exist in systems coupled by an ontogenetic niche shift. However, mainly the simplest system, i.e., the oneconsumertworesource system, has been studied previously, and little is known about the development of ASS ...


Wilson Shaun K   2011
[This corrects the article on p. e15185 in vol. 5.].


Blackie Helen M   2010
1. The causes of juvenile sexbiased philopatry and space use in mammals remain poorly understood, and results of previous research have been conflicting. Experimental interventions and manipulations on wild populations are rare, but can play an important role in establishing the factors governing offspring space use. 2. We experimentally removed ...


Brown Elizabeth R ER Department of Biostatistics, University of Washington, Seattle, Washington 98195, USA.   2010
We present a Bayesian model to estimate the timevarying sensitivity of a diagnostic assay when the assay is given repeatedly over time, disease status is changing, and the gold standard is only partially observed. The model relies on parametric assumptions for the distribution of the latent time of disease onset ...


Field J C   2010
Juvenile rockfish (Sebastes spp.) are important prey to seabirds in the California Current System, particularly during the breeding season. Both seabird breeding success and the abundance of pelagic juvenile rockfish show high interannual variability. This covariation is largely a response to variable ocean conditions; however, fishing on adult rockfish may ...


Bonner Simon J   2010
Summary Time varying, individual covariates are problematic in experiments with marked animals because the covariate can typically only be observed when each animal is captured. We examine three methods to incorporate time varying, individual covariates of the survival probabilities into the analysis of data from markrecapturerecovery experiments: deterministic imputation, a ...


Rummel D   2010
Summary We introduce a correction for covariate measurement error in nonparametric regression applied to longitudinal binary data arising from a study on human sleep. The data have been surveyed to investigate the association of some hormonal levels and the probability of being asleep. The hormonal effect is modeled flexibly while ...


Tooze Janet A JA Department of Biostatistical Sciences, School of Medicine, Wake Forest University, Medical Center Boulevard, WinstonSalem, NC 27157, USA.   2010
It is of interest to estimate the distribution of usual nutrient intake for a population from repeat 24h dietary recall assessments. A mixed effects model and quantile estimation procedure, developed at the National Cancer Institute (NCI), may be used for this purpose. The model incorporates a BoxCox parameter and covariates ...


Skene Simon S   2010
The statistical analysis of repeated measures or longitudinal data always requires the accommodation of the covariance structure of the repeated measurements at some stage in the analysis. The general linear mixed model is often used for such analyses, and allows for the specification of both a mean model and a ...


Staff Jeremy   2010
Most criminological theories predict an inverse relationship between employment and crime, but teenagers' involvement in paid work during the school year is positively correlated with delinquency and substance use. Whether the workdelinquency association is causal or spurious has long been debated. This study estimates the effect of paid work on ...


JacqminGadda Hélène   2010
Ordinal and quantitative discrete data are frequent in biomedical and neuropsychological studies. We propose a semiparametric model for the analysis of the change over time of such data in longitudinal studies. A threshold model is defined where the outcome value depends on the current value of an underlying Gaussian latent ...


Ciolino Jody   2011
Motivated by potentially serious imbalances of continuous baseline covariates in clinical trials, we investigated the cost in statistical power of ignoring the balance of these covariates in treatment allocation design for a logistic regression model. Based on data from a clinical trial of acute ischemic stroke treatment, computer simulations were ...


Alba David M   2011
The hominoid right partial humerus IPS4334, from the middle Miocene (MN 8) of Castell de Barberà (VallèsPenedès Basin, Catalonia, Spain), is described. It preserves the middistal portion of the shaft until the proximal margins of the radial and coronoid fossae, as well as the proximal portion of the olecranon fossa; ...


Yang Yan Y School of Mathematical and Statistical Sciences, Arizona State University, Tempe, AZ 85287, USA.   2012
Health and safety studies that entail both incidence and magnitude of effects produce semicontinuous outcomes, in which the response is either zero or a continuous positive value. Zeroinflated leftcensored models typically employ latent mixture constructions to allow different covariate processes to impact the incidence versus the magnitude. Assessment of the ...


Schall Robert   2011
We investigate mixed analysis of covariance models for the 'onestep' assessment of conditional QT prolongation. Initially, we consider three different covariance structures for the data, where betweentreatment covariance of repeated measures is modelled respectively through random effects, random coefficients, and through a combination of random effects and random coefficients. In ...


Sinha Sanjoy K   2010
In this article, we propose and explore a multivariate logistic regression model for analyzing multiple binary outcomes with incomplete covariate data where auxiliary information is available. The auxiliary data are extraneous to the regression model of interest but predictive of the covariate with missing data. describe how the auxiliary information ...


Zou Kelly H   2010
Patient reported outcome and observer evaluative studies in clinical trials and posthoc analyses often use instruments that measure responses on ordinalrating or Likert scales. We propose a flexible distributional approach by modeling the change scores from the baseline to the end of the study using independent beta distributions. The two ...


Ghosh Joyee J Department of Statistics and Actuarial Science, The University of Iowa, Iowa City, Iowa 52242, USA.   2011
In this article, we develop a latent class model with class probabilities that depend on subjectspecific covariates. One of our major goals is to identify important predictors of latent classes. We consider methodology that allows estimation of latent classes while allowing for variable selection uncertainty. We propose a Bayesian variable ...


Lee ShenMing   2011
Summary We consider the estimation problem of a proportional odds model with missing covariates. Based on the validation and nonvalidation data sets, we propose a joint conditional method that is an extension of Wang et al. (2002, Statistica Sinica 12, 555574). The proposed method is semiparametric since it requires neither an additional ...


Baldi F   2010
The objective of this work was to estimate covariance functions using random regression models on Bsplines functions of animal age, for weights from birth to adult age in Canchim cattle. Data comprised 49,011 records on 2435 females. The model of analysis included fixed effects of contemporary groups, age of dam ...


Murphy T E TE Department of Internal Medicine, Yale University School of Medicine, PO Box 208034, New Haven, CT 065208034,   2011
Longitudinal studies in gerontology are characterized by termination of measurement from death. Death is related to many important gerontological outcomes, such as functional disability, and may, over time, change the composition of an older study population. For these reasons, treating death as noninformative censoring of a longitudinal outcome may result ...


Schall Robert   2010
We investigate mixed models for repeated measures data from crossover studies in general, but in particular for data from thorough QT studies. We extend both the conventional random effects model and the saturated covariance model for univariate crossover data to repeated measures crossover (RMC) data; the resulting models we call ...


A Bayesian proportional hazards regression model with nonignorably missing timevarying covariates.
Bradshaw Patrick T PT Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.   2010
Missing covariate data are common in observational studies of time to an event, especially when covariates are repeatedly measured over time. Failure to account for the missing data can lead to bias or loss of efficiency, especially when the data are nonignorably missing. Previous work has focused on the case ...


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