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Song Saeheum S Daiichi Sankyo Pharma Development, Edison, NJ, - - 2014
Edoxaban is an oral, once-daily, direct factor Xa (FXa) inhibitor that has been evaluated for the prevention of stroke in patients with atrial fibrillation (AF) and for the treatment and prevention of venous thromboembolism (VTE) recurrence. Pharmacokinetic (PK) and pharmacodynamic (PD) modeling and logistic regression analyses were used to explore ...
Jelliffe Roger W RW Laboratory of Applied Pharmacokinetics, Keck School of Medicine, University of Southern California, Children's Hospital of Los Angeles, MS # 51, 4650 Sunset Blvd, Los Angeles, CA, 90027, USA, - - 2014
This report examined the role of digitalis pharmacokinetics in helping to guide therapy with digitalis glycosides with regard to converting atrial fibrillation (AF) or flutter to regular sinus rhythm (RSR). Pharmacokinetic models of digitoxin and digoxin, containing a peripheral non-serum effect compartment, were used to analyze outcomes in a non-systematic ...
Girgis I G IG Janssen Pharmaceuticals Research & Development, Raritan, NJ, - - 2014
Two once-daily rivaroxaban dosing regimens were compared with warfarin for stroke prevention in patients with non-valvular atrial fibrillation in ROCKET AF: 20 mg for patients with normal/mildly impaired renal function and 15 mg for patients with moderate renal impairment. Rivaroxaban population pharmacokinetic (PK)/pharmacodynamic (PD) modeling data from ROCKET AF patients (n = 161) are ...
Lourenco D A L DA Department of Animal and Dairy Science, University of Georgia, Athens 30602. Electronic address: - - 2014
Data sets of US Holsteins, Israeli Holsteins, and pigs from PIC (a Genus company, Henderson, TN) were used to evaluate the effect of different numbers of generations on ability to predict genomic breeding values of young genotyped animals. The influence of including only 2 generations of ancestors (A2) or all ...
Charitos Efstratios I EI Department of Cardiac and Thoracic Vascular Surgery, University of Luebeck, Luebeck, - - 2014
Estimates of atrial fibrillation (AF) burden (AFB) derived from intermittent rhythm monitoring (IRM) are increasingly being used as an outcome measure after therapeutic interventions; however, their accuracy has never been validated. The aim of this study was to compare IRM-derived AFB estimates to the true AFB as measured by implantable ...
Mohebbi Maryam M Department of Electrical and Computer Engineering, K. N. Toosi University of Technology, Tehran, Iran, - - 2014
This paper presents an algorithm for predicting termination of paroxysmal atrial fibrillation (AF) attacks using features extracted from the atrial activity (AA) and heart rate variability (HRV) signals. First, AA signal was decomposed into a set of intrinsic mode functions (IMFs) using empirical mode decomposition method. Then, power spectrums of ...
Mörk Anna-Karin AK Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. Electronic address: - - 2014
The availability of experimental data suitable as a basis to quantify human variability in response to chemical exposure has increased in recent years. It has enabled scientifically based, data driven adjustment factors (AF) to be deployed in the risk assessment process. As part of this development, we derive AF for ...
Labus Kevin - - 2014
Interlamellar (IL) shear may play an important role in the homeostasis of the intervertebral disc and disc degeneration. Accurately modeling the shear behavior of the IL compartment would enhance the study of its mechanobiology. In this study, physical experiments were utilized to describe IL shear and define a constitutive model, ...
Julián M M Biomedical Synergy, Electronic Engineering Department, Universidad Politécnica de Valencia, Edificio 7F, 5(a). Camino de Vera s/n. 46022, Valencia, Spain. Electronic address: - - 2014
Atrial fibrillation (AF) is today the most common sustained arrhythmia, its treatment being not completely satisfactory. Electrical activity organization analysis within the atria could play a key role in the improvement of current AF therapies. The application of a nonlinear regularity index, such as sample entropy (SampEn), to the atrial ...
Mills J A N JA The University of Reading, Centre for Dairy Research, Department of Agriculture, Reading, RG6 6AT, - - 2014
Current feed evaluation systems for ruminants are too imprecise to describe diets in terms of their acidosis risk. The dynamic mechanistic model described herein arises from the integration of a lactic acid (La) metabolism module into an extant model of whole-rumen function. The model was evaluated using published data from ...
Zhou Xiaolin - - 2014
Atrial fibrillation (AF) is the most common and debilitating abnormalities of the arrhythmias worldwide, with a major impact on morbidity and mortality. The detection of AF becomes crucial in preventing both acute and chronic cardiac rhythm disorders. Our objective is to devise a method for real-time, automated detection of AF ...
Gastin Paul B PB a Centre for Exercise and Sports Science, School of Exercise and Nutrition Sciences , Deakin University , Burwood , - - 2014
Abstract The effectiveness of a wearable microsensor device (MinimaxX(TM) S4, Catapult Innovations, Melbourne, VIC, Australia) to automatically detect tackles and impact events in elite Australian football (AF) was assessed during four matches. Video observation was used as the criterion measure. A total of 352 tackles were observed, with 78% correctly ...
Dorota Zielińska Z Department of Food Gastronomy and Food Hygiene, Faculty of Human Nutrition and Consumer Sciences, Warsaw University of Life Sciences - SGGW, ul. Nowoursynowska 159c, 02-776, Warsaw, Poland, - - 2014
The aim of the study was to construct and verify predictive growth and survival models of a potentially probiotic bacteria in fermented soy beverage. The research material included natural soy beverage (Polgrunt, Poland) and the strain of lactic acid bacteria (LAB) - Lactobacillus casei KN291. To construct predictive models for ...
Kalwij Jesse M JM Institute of Ecology and Earth Sciences, University of Tartu, Tartu, Estonia ; Department of Zoology, University of Johannesburg, Auckland Park, South - - 2014
Much ecological research relies on existing multispecies distribution datasets. Such datasets, however, can vary considerably in quality, extent, resolution or taxonomic coverage. We provide a framework for a spatially-explicit evaluation of geographical representation within large-scale species distribution datasets, using the comparison of an occurrence atlas with a range atlas dataset ...
Daqrouq K K Electrical and Computer Engineering Department, King Abdulaziz University, Saudi Arabia. Electronic address: - - 2014
ECG signals are an important source of information in the diagnosis of atrial conduction pathology. Nevertheless, diagnosis by visual inspection is a difficult task. This work introduces a novel wavelet feature extraction method for atrial fibrillation derived from the average framing percentage energy (AFE) of terminal wavelet packet transform (WPT) ...
Gaines Karen F KF Department of Biological Sciences, Eastern Illinois University, 600 Lincoln Ave, Charleston, IL, 61920, USA, - - 2014
The U.S. Department of Energy's (USDOE) Savannah River Site (SRS) is a former nuclear weapon material production and current research facility adjacent to the Savannah River in South Carolina, USA. The purpose of this study was to determine the background radiocesium ((137)Cs) body burden (e.g., from global fallout) for white-tailed ...
Park Mi-Hyun MH Division of Intractable Diseases, Center for Biomedical Sciences, National Institute of Health, Chungcheongbuk-do, South - - 2014
Next-generation sequencing (NGS) has enabled the high-throughput discovery of germline and somatic mutations. However, NGS-based variant detection is still prone to errors, resulting in inaccurate variant calls. Here, we categorized the variants detected by NGS according to total read depth (TD) and SNP quality (SNPQ), and performed Sanger sequencing with ...
Sultan Kiran K 0000-0003-0241-5712 Department of Electrical Engineering, Air University, Islamabad, - - 2014
Cooperative communication is regarded as a key technology in wireless networks, including cognitive radio networks (CRNs), which increases the diversity order of the signal to combat the unfavorable effects of the fading channels, by allowing distributed terminals to collaborate through sophisticated signal processing. Underlay CRNs have strict interference constraints towards ...
Cortes Daniel H DH Department of Biomedical Engineering, University of Delaware, Newark, 125 E Delaware Ave., DE 19716, United - - 2013
The aim of functional tissue engineering is to repair and replace tissues that have a biomechanical function, i.e., connective orthopaedic tissues. To do this, it is necessary to have accurate benchmarks for the elastic, permeability, and swelling (i.e., biphasic-swelling) properties of native tissues. However, in the case of the intervertebral ...
Rendu William W Center for International Research in the Humanities and Social Sciences, Unité Mixte Internationale 3199, Centre National de la Recherche Scientifique (CNRS)-New York University, New York, NY - - 2013
The bouffia Bonneval at La Chapelle-aux-Saints is well known for the discovery of the first secure Neandertal burial in the early 20th century. However, the intentionality of the burial remains an issue of some debate. Here, we present the results of a 12-y fieldwork project, along with a taphonomic analysis ...
Lord J - - 2013
National Institute for Health and Care Excellence (NICE) clinical guidelines (CGs) make recommendations across large, complex care pathways for broad groups of patients. They rely on cost-effectiveness evidence from the literature and from new analyses for selected high-priority topics. An alternative approach would be to build a model of the ...
Du Xiaochuan - - 2013
Automatic detection of atrial fibrillation (AF) in electrocardiograms (ECGs) is beneficial for AF diagnosis, therapy, and management. In this article, a novel method of AF detection is introduced. Most current methods only utilize the RR interval as a critical parameter to detect AF; thus, these methods commonly confuse AF with ...
Ng Jason - - 2013
Atrial fibrillation (AF) electrograms are characterized by varying morphology, amplitude, and cycle lengths (CLs), presenting a challenge for automated detection of individual activations and the activation rate. In this study, we evaluate an algorithm to detect activations and measure CLs from AF electrograms. This algorithm iteratively adjusts the detection threshold ...
Vogt Torsten - - 2013
The Systems Biology Graphical Notation (SBGN) provides standard graphical languages for representing cellular processes, interactions, and biological networks. SBGN consists of three languages: Process Descriptions (PD), Entity Relationships (ER), and Activity Flows (AF). Maps in SBGN PD are often large, detailed, and complex, therefore there is a need for a ...
Martín-Montañez Vicente - - 2013
Purpose: To analyze in vitro the influence of different environmental conditions on the dehydration pattern of seven currently marketed hydrogel (Hy) and silicone hydrogel (Si-Hy) contact lenses (CL). Methods: Three Hy and four Si-Hy CLs were evaluated. CLs were exposed to four different relative humidity (RH) conditions (5%, 30%, 50%, ...
Ciaccio Edward J - - 2013
Measurements of both the dominant frequency (DF) and the time series morphology of complex fractionated atrial electrograms (CFAE) are useful to distinguish persistent from paroxysmal atrial fibrillation (AF). In this study, an algorithm was devised to extract morphologic components according to frequency, and its usefulness for distinguishing CFAE was shown. ...
Zheng Yefeng - - 2013
As a minimally invasive surgery to treat atrial fibrillation (AF), catheter based ablation uses high radio-frequency energy to eliminate potential sources of abnormal electrical events, especially around the ostia of pulmonary veins (PV). Fusing a patient-specific left atrium (LA) model (including LA chamber, appendage, and PVs) with electro-anatomical maps or ...
Chaturvedi Ashutosh - - 2013
Objective. Clinical deep brain stimulation (DBS) systems can be programmed with thousands of different stimulation parameter combinations (e.g. electrode contact(s), voltage, pulse width, frequency). Our goal was to develop novel computational tools to characterize the effects of stimulation parameter adjustment for DBS. Approach. The volume of tissue activated (VTA) represents ...
Gutiérrez-Tobal Gonzalo C - - 2013
This paper aims at detecting sleep apnoea-hypopnoea syndrome (SAHS) from single-channel airflow (AF) recordings. The study involves 148 subjects. Our proposal is based on estimating the apnoea-hypopnoea index (AHI) after global analysis of AF, including the investigation of respiratory rate variability (RRV). We exhaustively characterize both AF and RRV by ...
Nam Sun-Hwa - - 2013
This study focused on estimating the toxicity values of various aquatic organisms exposed to gold (III) ion (Au(3+)), and to propose maximum guideline values for Au(3+) toxicity that protect the aquatic ecosystem. A comparative assessment of methods developed in Australia and New Zealand versus the European Community (EC) was conducted. ...
Ozmen Ozlem - - 2013
This paper provides a safety evaluation of a special protected/permitted left turn signal control (Las Vegas LT Display) that has been implemented in the urbanized area of Las Vegas, Nevada. The Las Vegas LT Display eliminates the yellow trap condition for leading approach in lead/lag operation. It provides protected only ...
Stafiński Maciej - - 2013
The recovery test in the "surrogate" mode is often exploited for trueness assessment when appropriate certified reference materials are not available or to support reference material studies. The species effect occurs when chemical forms of native and surrogate analytes are different. It usually results in obtaining incomparable analytical signals for ...
Donoso Felipe I - - 2013
In this paper we apply independent component analysis (ICA) followed by second order blind identification (SOBI) to an atrial fibrillation (AF) 12-lead electrocardiogram (ECG) recording in order to extract the source that represents atrial activity (AA) (ICA-SOBI method). Still, there is no assurance that only one source obtained from this ...
Bhat G - - 2013
Objective:The objective of this study was to assess the role of biomarker interactions as predictors of spontaneous preterm birth (PTB) using multifactor dimensionality reduction (MDR) analysis. With MDR, a nonparametric, unsupervised, model-free approach, we tested for biomarker interactions within maternal-fetal compartments in 2 racial groups: African Americans (AA) and Caucasians ...
Krueger Martin W - - 2013
Atrial fibrillation (AF) is the most common cardiac arrhythmia, and the total number of AF patients is constantly increasing. The mechanisms leading to and sustaining AF are not completely understood yet. Heterogeneities in atrial electrophysiology seem to play an important role in this context. Although some heterogeneities have been used ...
Colilla Susan - - 2013
Estimates and projections of diagnosed incidence and prevalence of atrial fibrillation (AF) in the United States have been highly inconsistent across published studies. Although it is generally acknowledged that AF incidence and prevalence are increasing due to growing numbers of older people in the U.S. population, estimates of the rate ...
Meo Marianna - - 2013
Catheter ablation (CA) is increasingly employed to treat persistent atrial fibrillation (AF), yet assessment of procedural AF termination is still a subject of debate in the medical community. This has motivated the development of different criteria based on the standard electrocardiogram (ECG) to characterize ablation immediate effectiveness. However, most of ...
Vigmond Edward - - 2013
Atrial fibrillation is the most commonly encountered clinical arrhythmia. Despite recent advances in treatment by catheter ablation, its origin is still incompletely understood and it may be difficult to treat. Computer modelling offers an attractive complement to experiment. Simulations of fibrillation, however, are computationally demanding since the phenomenon requires long ...
Kwon Soon-Sung - - 2013
The purpose of this study was to propose a patient-specific model of atrial fibrillation (AF) and apply it to virtual radiofrequency ablation (RFA). We obtained patient-specific geometries of the left atrium (LA) from CT data and constructed three-dimensional (3D) simulation models. A bidomain Courtemanche model was used to simulate the ...
Donoso Felipe I - - 2013
Atrial fibrillation (AF) is the most common arrhythmia encountered in clinical research. In particular, the study of AF types or sub-classes is a very interesting research topic. In this paper we present a preliminary study to find sub-classes of AF from real 12-lead ECG recordings using k-means and hierarchical clustering ...
Corino Valentina D A - - 2013
The atrioventricular (AV) node plays a central role during atrial fibrillation (AF). We have recently proposed a statistical AV node model defined by parameters characterizing the arrival rate of atrial impulses, the probability of an impulse choosing either one of the dual AV nodal pathways, the refractory periods of the ...
Dai Huhe - - 2013
In this paper we proposed a novel technique for Atrial Activity (AA) decomposition in Electrocardiogram (ECG) of Atrial Fibrillation (AF). The main purpose of our proposed technique is to decompose AA signal by combining two statistical methods, Independent Component Analysis (ICA)-existing and Weighted Average Beat Subtraction (WABS)-new, for AF with ...
Raposo do Amaral Fábio - - 2013
The Atlantic Forest (AF) harbours one of the most diverse vertebrate faunas of the world, including 199 endemic species of birds. Understanding the evolutionary processes behind such diversity has become the focus of many recent, primarily single locus, phylogeographic studies. These studies suggest that isolation in forest refugia may have ...
Makgahlela M L - - 2013
Different approaches of calculating genomic measures of relationship were explored and compared with pedigree relationships (A) within and across base breeds in a crossbreed population, using genotypes for 38,194 loci of 4,106 Nordic Red dairy cattle. Four genomic relationship matrices (G) were calculated using either observed allele frequencies (AF) across ...
Huchet V - - 2013
Molds are responsible for spoilage of bakery products during storage. A modeling approach to predict the effect of water activity (aw) and temperature on the appearance time of Aspergillus candidus was developed and validated on cakes. The gamma concept of Zwietering was adapted to model fungal growth, taking into account ...
Lee Jinseok - - 2013
We introduce a novel method for automatic detection of Atrial Fibrillation (AF) using time-varying coherence functions (TVCF). The TVCF is estimated by the multiplication of two time-varying transfer functions (TVTFs). The two TVTFs are obtained using two adjacent data segments with one data segment as the input signal and the ...
Frahm Ken Steffen - - 2013
During electrocutaneous stimulations, variation in skin properties across locations can lead to differences in neural activation. However, little focus has been given to the effect of different skin thicknesses on neural activation. Electrical stimulation was applied to six sites across the sole of the foot. The intensities used were two ...
Campbell Peter - - 2013
The draft SANCO document represents the state of the art in environmental risk assessment (ERA) including new trends and combining high level environmental protection and realism. Utilizing the ecosystem services concept it offers a promising approach to determine which impact may be tolerable, where and when. Established ERA uses a ...
Alcaraz Raúl - - 2013
Atrial fibrillation (AF) is the most commonly diagnosed arrhythmia in clinical practice. However, the mechanisms responsible for its induction and maintenance still are not fully understood. To this respect, analysis of the electrical activity organization within the atria could play an important role in their proper interpretation. Although many algorithms ...
Campos Fernando O FO Institute of Biophysics, Medical University of Graz, 8036 Graz, Austria, and with the Institute of Medical Engineering, Graz University of Technology, 8010 Graz, Austria. - - 2013
Fibrosis is thought to play an important role in the formation and maintenance of atrial fibrillation (AF). The propensity of fibrosis to increase AF vulnerability depends not only on its amount, its texture plays a crucial role as well. While the detection of fibrotic tissue patches in the atria with ...
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