Cotton-wool spots are a hallmark of human immunodeficiency virus (HIV) retinopathy in the acquired immunodeficiency syndrome (AIDS). We analysed the half-life of cotton-wool spots in AIDS in a prospective study, and found the average time to disappearance to be 6.9 weeks. HIV retinopathy differs from diabetic retinopathy in having a ...

Retroviruses emerged before Homo sapiens in the course of vertebrate evolution. The first human retrovirus was isolated in 1979; the human immunodeficiency virus (HIV-1) assumed epidemic importance in 1981. That such a novel threat to the survival of our species struck only when we had in place, for the first ...

Two major global problems face mankind in the forthcoming decades. The rapidly increasing populations, especially in developing countries, are already causing social and economic strain in many areas, and the escalating demand for energy at both the individual and collective levels are matters requiring serious global attention. The product of ...

Rabbit erythrocyte ghost (REG) membranes and human erythrocyte ghosts (HEG) were aligned into contact by dielectrophoresis and fused with an electric pulse in REG + REG, HEG + HEG, and REG + HEG combinations. REG + HEG fusion yields were approximately midway between fusion yields for REG + REG and ...

The anti-human immunodeficiency virus drug zidovudine is metabolized extensively in human beings to the 5'-glucuronide (GAZT) and is cleared rapidly, resulting in a short half-life and the need for frequent dosing. This study explores whether probenecid, which is also metabolized by glucuronidation, reduces zidovudine clearance when zidovudine is administered orally ...

Studies on the production and characterization of anti-idiotype antibodies (AId) to monoclonal factor VIII antibodies (McFVIIIAb) are reported. Two AIds were produced and one of these exhibited cross-reactivity with two other McFVIIIAb but showed no reactivity with haemophilic and non-haemophilic FVIIIAb. This AId was also active against McFVIIIAb which bound ...

The hydrolysis of birch and timothy pollen allergen preparations by duodenal juice from an adult volunteer was studied in vitro with the aid of rocket immunoelectrophoresis, radiorocket immunoelectrophoresis and RAST-inhibition. The results achieved with all methods were similar. The duodenal juice had the capacity to hydrolyse both the grass and ...

This paper discusses the concept of human-centred advanced manufacturing technology (AMT) and the role of ergonomics in its design and development. Various methods of human-centred design are illustrated through two examples taken from the Commission of European Communities' ESPRIT initiative. Difficulties which have been encountered are outlined and the methods ...

The paper begins by outlining the growing market for Advanced Manufacturing Technology, providing a sample scenario and some instances of the human factors issues underlying this scenario. The importance of knowledge is emphasised. Two classes of 'knowledge-manipulating' knowledge and 'data-manipulating' knowledge are discussed, and the problems of error propagation are ...

The present paper overviews the forthcoming PCB problems from current knowledge of their use, environmental contamination and toxicology. From a global point of view, PCB levels in the environmental media and biota are unlikely to decline in the near future due to the greater quantities of PCBs still in use ...

Asbestos dust has got a very great importance because cancerogenicity is imputed into it in occupational and, perhaps, in common environmental conditions too. The short review deals with general problems in experimenting with fibrous dusts, especially the modes of its application, the transferability of results to human pathology and the ...

Over the past 25 years animal retroviruses have been favoured subjects of research by virologists, oncologists, and molecular biologists. Retroviruses have given us reverse transcriptase, oncogenes, and cloning vectors that may one day be exploited for human gene therapy. They have also given us leukaemia and the acquired immune deficiency ...

The acquired immune deficiency syndrome (AIDS) is characterized by severe immunological defects resulting in opportunistic infections and malignancies. A novel human retrovirus, known under the terms of LAV, HTLV-III, ARV or as a human immunodeficiency virus (HIV), has been defined as the infectious agent responsible for the induction of the ...

Recent evidence has demonstrated that human T-lymphotropic retroviruses are present in the brain of patients with acquired immunodeficiency syndrome (AIDS). Studies by neuropathological, ultrastructural and nucleic acid hybridization techniques indicate that these human retroviruses are neurotropic as well as lymphotropic. Striking similarities to the animal retroviruses of the lentivirus subfamily ...

In vivo neutron activation analysis (NAA) is currently used to measure body composition in metabolic and nutritional studies in many clinical situations, but has not previously been validated by comparison with chemical analysis of human cadavers. Total body nitrogen (TBN) and chlorine (TBCl) were measured in two human cadavers by ...

The purpose of this character study is not to assess the achievements of this great paediatric surgeon but to describe this extraordinary, adventurous, rebellious and difficult man, his intelligence, intellectual curiosity and intense interest in technical problems, as well as his bluntness of manner which was confusing and irritating to ...

Problems associated with estimation of human exposure to ambient air pollutants are discussed. Ideally, we would prefer to have some indication of actual dose. For most pollutants this is not presently feasible. Specific problems discussed are adequacy of outdoor monitors; the need to correct for exposures and time spent indoors; ...

A scanning electron microscopic (SEM) cast method that has been utilized to examine the internal structure of dentine was modified to examine canalicular communications in the cortices of a human femur and ulna. Although some preparations in which all of the matrix was removed were examined, etched preparations were found ...

Twenty young adult subjects were selected to determine normal baseline data of dynamic interdental bite force discrimination by use of a specially designed strain gauge instrument. The data may aid in defining the role of the periodontal ligament, temporomandibular joint and muscles of mastication in the regulation of interincisor bite ...

This paper reviews the major features of a simian model of acquired immunodeficiency ('SAIDS'), SAIDS occurs endemically in colonies of macaque monkeys in the United States and resembles AIDS in humans in overall clinical manifestations, pathology, and immune deficiency. An infectious type D retrovirus, related to but distinct from the ...

Human adipose tissue samples obtained during autopsies in a Canadian Great Lakes community, Kingston, Ontario, and a second community, Ottawa, Ontario, were analyzed for organochlorine pesticides, polychlorobiphenyls, chlorobenzenes, and chlorophenols. Significantly different levels of Dichlorodiphenyl -dichloroethane, mirex, hexachlorobenzene, and 2,3,4,6-tetrachlorophenol were found in Kingston adipose tissues compared to Ottawa tissues. ...

Human small nuclear ribonucleoproteins (snRNPs) containing U1 and U2 snRNAs have been isolated from cultured cells by nonimmunological methods. The U1 snRNP population remained immunoprecipitable by systemic lupus erythematosis anti-RNP and anti-Sm antibodies throughout fractionation and contained polypeptides of molecular weights corresponding to those defined as U1 snRNP polypeptides by ...

The literature of biology abounds in awe-inspiring acts of iridescent genius. Although a law of nature is phrased in abstract language and is itself devoid of passion and sensibility, the history of its discovery may be an epic worthy of Homer, every page of which bears the stamp of the ...

Animal bites are an extremely common problem in the United States. Dogs are by far the most common offender, closely followed by cats, humans, and rats. Most injuries are trivial, but can become infected, and fatalities do occur. A wide variety of organisms cause a multitude of clinical problems, but ...

Certain signaling functions of the pitch of voice are remarkably similar across languages and cultures: (1) high or rising pitch to mark questions, low or falling pitch to mark nonquestions; (2) high pitch to signal politeness, low pitch to signal assertiveness; (3) in 'sound symbolic' vocabulary, high tone used with ...

As just described, NIOSH's ongoing and new activities offer varied approaches and opportunities for gaining insights into human factor and ergonomic aspects of workplace hazards and their control. They represent a blend of surveillance work (re, the prevalence survey of chronic trauma risk), in-depth studies of known workplace problems emphasizing ...

The paper introduces three extensions of the A* search algorithm which improve the search efficiency by relaxing the admissibility condition. 1) A* employs an admissible heuristic function but invokes quicker termination conditions while still guaranteeing that the cost of the solution found will not exceed the optimal cost by a ...

The distribution of axial stress on the end-plate of the vertebral body has been measured by the aid of miniature piezoelectric pressure transducers in specimens of motion segments of the human vertebral column. The results indicate that the stress distribution depends essentially on the state of degeneration of the intervertebral ...

There is currently great interest in the use of paradox in psychotherapy. Unfortunately, there is also considerable confusion and misunderstanding of paradox, owing, in part, to the lack of a comprehensive theory that explains the role of paradox in human problems. This paper does not address itself to such theory ...

(131)Iodine ((131)I) labelled antibody directed against human chorionic gonadatrophin (hCG) was given on 21 occasions to 18 patients with hCG-producing neoplasms. Tumours were localized by external scintigraphy in 13 of 21 investigations. Positive results were obtained reliably when serum hCG exceeded 500 miu/ml and in some cases sensitivity was comparable ...

In a previous communication we reported that human erythrocyte glycophorin prepared by the lithium diiodosalicylate phenol procedure contains approximately 10 mol of lithium diiodosalicylate per mol of glycophorin, and further we showed that this bound lithium diiodosalicylate is difficult to remove by detergents or organic solvents (Romans, A.Y. and Segrest, ...

The human intervertebral discs which were obtained by cadavers and anterior discectomy are investigated histochemically. Chondroitin-4S, chondroitin-6S, dermatan sulfate, hyaluronic acid and keratan sulfate were detected in the human intervertebral disc by various histochemical methods. pH2.5, pH1.1 toluidin blue metachromasia and 0.4M MgCl2 alcianophilia became weaker with increasing age, and ...

Factors that require consideration in extending carcinogen bioassay protocols to include transplacental exposure of rodent subjects are summarized. These include metabolic complexities and biologic problems, such as the differences in fetal susceptibility to lethal, teratogenic, and carcinogenic effects of the same compound at different stages of intrauterine development, and that, ...

Artifactual and nonartifactual evidence from the lacustrine shores of the Chalco-Xochimilco Basin suggest the existence of fully sedentary human communities in the Basin of Mexico from at least the sixth millennium B.C.

Bradykinin is able to stimulate sperm migration of SPFS; HMW kininogen does not effect sperm migration of SPFS; Kallikrein and acrosin induce small stimulation of sperm migration of SPFS indicating traces of kininogen attached to the sperm surface enabling liberation of kinins; In the presence of kininogen, kallikrein and acrosin ...

Recent investigations at Tokyo International Airport have proven that environmental pollution resulting from the inefficient disposal of human excretion aboard aircraft is an important problem from the standpoint of quarantine. It is, therefore, recommended that the worldwide aviation industry take immediate measures to improve conditions and eliminate this problem, which ...

This paper review our modification of the vasoconstrictor (blanching) assay for topical corticosteroids using human volunteers, which we have improved and extended so that it may be used as a useful screening test for clinical efficacy besides being employed to determine the bioavailability of steroids from topical bases. Work is ...

This article reports on a 5-year study of 198 articular discs of the human temporomandibular joint. The investigation revealed a striking incidence of disc degeneration, notably bilaterally presented. The classification used to qualify the condition of the discs consisted of maximal and minimal degeneration and normalcy. We sought to establish ...

By analogy with the problem of evaluating the genetic risks of radiation, it appears that it will be extremely difficult to assess the mutagenicity for man of the wide range of chemicals to which human populations are currently exposed. Nevertheless, the potential significance of this problem calls for a major ...

Although considerable thought has been given to human problems arising from the use of automation, very little attention has been devoted to the human problems encountered during its introduction. This article reviews various stages of the design and installation of an automated system from the human aspect. Stress is laid ...

Thesis (M.S.)--School of Dentistry. University of Missouri--Kansas City, 2004.

I suggest that the T4 lymphopenia of AIDS may be caused by antibodies raised against the human immunodeficiency virus that block the generation of T4 cells.

This fact sheet on antibiotic residues in milk and meat of dairy cows, is published by the University of California Davis' Veterinary Medical Extension programme. This programme seeks to develop and disseminate information about animal and human health in relation to animals or animal products. This fact sheet outlines some ...

A comparison of the results of machine and human information retrieval using MEDLARS and the printed Index Medicus indicates that at present neither method is entirely satisfactory for exhaustive literature searches. The advantages and disadvantages of machine and manual search methods are discussed, and solutions to some of the problems ...

When macroaggregates of radioiodinated human serum albumin are injected into the celiac axis at the conclusion of celiac arteriography, satisfactory scans in which hepatic, splenic and pancreatic-duodenal out-lines are present can be obtained. Following preliminary experiments in dogs, five patients were scanned after celiac arteriography and injection of macroaggregates. No ...

This paper is concerned mainly with the relationship between microfilarial periodicity and vector periodicity. The so-called "non-periodic" Pacific form of Wuchereria bancrofti in fact shows a well-marked and relatively constant periodicity. The amplitude of this periodicity is low, which may account for the difficulty of detecting it in small clinical ...

Local introduction of atropine and dibenzyline into human skin was carried out by iontophoresis. Both thermoregulatory and emotional sweating were blocked by atropine but were not blocked by dibenzyline. It would seem that emotional sweating produced as a result of a physical stress situation is partly or predominately under cholinergic ...