Activation-induced cytidine deaminase (AID) is required for both somatic hypermutation and class-switch recombination in activated B cells. AID is also known to target nonimmunoglobulin genes and introduce mutations or chromosomal translocations, eventually causing tumors. To identify as-yet-unknown AID targets, we screened early AID-induced DNA breaks by using two independent genome-wide ...

Strategically a new approach for the synthesis tetrahydro-β-carboline unit with the aid of diethyl acetamidomalonate as a glycine equivalent has been described.

Anatomical and biomechanical studies have highlighted the importance of the deep attachment of the TFCC for maintaining stability of the distal radioulnar joint (DRUJ). The standard arthroscopic assessment of the TFCC does not allow one to definitively determine whether the deep fibers are indeed intact, and establishing the diagnosis of ...

To investigate the evidence of problem-solving approach interventions on symptom management in cancer care. Symptom-related problems are a common challenge in cancer care. The problem-solving approach is one strategy of cognitive behavioural therapy used to help patients with cancer self-manage their symptoms. However, no systematic review has investigated the effectiveness ...

Differential evolution (DE) is a simple, yet efficient, evolutionary algorithm for global numerical optimization, which has been widely used in many areas. However, the choice of the best mutation strategy is difficult for a specific problem. To alleviate this drawback and enhance the performance of DE, in this paper, we ...

Given a set of genotypes from a population, the process of recovering the haplotypes that explain the genotypes is called haplotype inference. The haplotype inference problem under the assumption of pure parsimony consists in finding the smallest number of haplotypes that explain a given set of genotypes. This problem is ...

MOTIVATION: Haplotype inference is an important step for many types of analyses of genetic variation in the human genome. Traditional approaches for obtaining haplotypes involve collecting genotype information from a population of individuals and then applying a haplotype inference algorithm. The development of high-throughput sequencing technologies allows for an alternative ...

Metro maps are schematic diagrams of public transport networks that serve as visual aids for route planning and navigation tasks. It is a challenging problem in network visualization to automatically draw appealing metro maps. There are two aspects to this problem that depend on each other: the layout problem of ...

Various theories have been put forward in an attempt to explain what makes moral judgments justifiable. One of the main theories currently advocated in bioethics is a form of coherentism known as wide reflective equilibrium. In this paper, I argue that wide reflective equilibrium is not a satisfactory approach for ...

Current savings strategies aren't sustainable. Here are new tactics.

Several approaches are being investigated for improving the elastic parabolic equation for problems involving sloping fluid-solid interfaces. Approaches based on single scattering and energy conservation provide accurate solutions for problems involving sloping fluid-fluid and solid-solid interfaces, but the mixed-media problem has proven to be more challenging. The energy-conservation approach has ...

We explore the maximum parsimony (MP) and ancestral maximum likelihood (AML) criteria in phylogenetic tree reconstruction. Both problems are NP-hard, so we seek approximate solutions. We formulate the two problems as Steiner tree problems under appropriate distances. The gist of our approach is the succinct characterization of Steiner trees for ...

The protein folding problem remains one of the most challenging open problems in computational biology. Simplified models in terms of lattice structure and energy function have been proposed to ease the computational hardness of this optimization problem. Heuristic search algorithms and constraint programming are two common techniques to approach this ...

The Problem of Application investigates the multiple viewpoints in defining a critical aesthetic in applied arts practice. Amongst organisations, participants, and facilitators there are varying wants and needs in any creative project with an educational agenda. The product of arts based health initiatives often seek to inform and educate, whereby ...

This paper discusses recent optimization approaches to the protein side-chain prediction problem, protein structural alignment, and molecular structure determination from X-ray diffraction measurements. The machinery employed to solve these problems has included algorithms from linear programming, dynamic programming, combinatorial optimization, and mixed-integer nonlinear programming. Many of these problems are purely ...

Regardless of how obstructive lung disease is labelled, targeting treatment to components of the problem is the best solution.

Peripheral neuropathies are a common problem with a myriad of potential etiologies that may be encountered acutely. Early diagnosis of certain neuropathies can lead to life-saving therapy. This article reviews the literature on diagnostic approaches to peripheral neuropathies and suggests a structured framework of pattern recognition and systematic evaluation to ...

AIM: To share the experiences of an adapted problem-based learning approach to audit within a palliative care setting. METHOD: A small group learning approach to design and undertake an audit. RESULT: This approach was a positive learning experience within clinical practice that enabled the group to develop their knowledge of ...

Commentaries by Derrfuss and Mar (Derrfuss, J., Mar, R., 2009. Lost in localization: the need for a universal coordinate database. Neuroimage.) and Nielsen (Nielsen, F.A., 2009. Lost in localization: a solution with neuroinformatics 2.0? Neuroimage.) outline the need for a universal coordinate database and some possible approaches to creating one. ...

In the past decades, many theoretical results related to the time complexity of evolutionary algorithms (EAs) on different problems are obtained. However, there is not any general and easy-to-apply approach designed particularly for population-based EAs on unimodal problems. In this paper, we first generalize the concept of the takeover time ...

We present a new approach to the microBmicro problem of gauge-mediated supersymmetry breaking. Rather than reducing the generically large contribution to Bmicro we point out that acceptable electroweak symmetry breaking can be achieved with micro{2}<<Bmicro if at the same time Bmicro<<mH{d}}{2}. This hierarchy can easily appear in models where the ...

The image reconstruction problem for fully 3D TOF PET is challenging because of the large data sizes involved. One approach to this problem is to first rebin the data into one of the following lower dimensional formats: 2D TOF, 3D non TOF or 2D non TOF. Here we present a ...

We consider optimal formulations of spread spectrum watermark embedding where the common requirements of watermarking, such as perceptual closeness of the watermarked image to the cover and detectability of the watermark in the presence of noise and compression, are posed as constraints while one metric pertaining to these requirements is ...

This study explores how couples' spirituality and relationship processes holistically interact to inform diabetes management. Qualitative analysis of interviews with 20 heterosexual couples identified five spiritual coping styles based on the spiritual meaning they ascribed to the situation and the nature of their relationships with God and each other: (a) ...

Graduation date: 1984

The "classical" treatment of solvent Stokes' shifts has been with us for 50 years or more. Twenty-five years ago, aided by new statistical mechanical underpinnings of liquid-state theory, Chandler and others [Thompson, M.; Schweizer, K.; Chandler, D. J. Chem. Phys. 1982, 76, 1128-1135. Schweizer, K.; Chandler, D. J. Chem. Phys. ...

A simplified approach to mathematical modeling/problem solving in global oxygen transport is presented. In addition to standard oxygen transport formulae, it uses the S-Factor and a mathematical relationship relating SvO(2) to the ratio DO(2)/VO(2). This method allows the determination or specification of SvO(2), PvO(2), P(50), and systemic shunting in the ...

The comparison of consecutively manufactured tools and firearms has provided much, but not all, of the basis for the profession of firearm and toolmark examination. The authors accept the fundamental soundness of this approach but appeal to the experimental community to close two minor gaps in the experimental procedure. We ...

INTRODUCTION: CAM is a socially constructed concept, and the literature on CAM definitions and patterns of use illustrates problems centering on the conceptualization and operationalization of "CAM." This renders it hard for researchers to truly understand CAM use patterns by the public. We use pilot data to explore lay conceptions ...

Wheeler WC and Pickett KM (2008. Topology-Bayes versus clade-Bayes in phylogenetic analysis. Mol Biol Evol. 25:447-453.) discuss two ways of summarizing the posterior probability distribution of a Bayesian phylogenetic analysis, which they refer to as "topology-Bayes" and "clade-Bayes." They claim that the clade-Bayes approach leads to problems such as "exaggerated ...

Early formulations of the RCWA yield, implicated by the erroneous application of factorization rules to discrete Fourier transformations, poor convergence in certain cases. An explanation for this finding and an approach to overcome the problem for crossed gratings was first given by Li [J. Opt. Soc. Am. A 13, 1870 ...

This paper investigates the problem of searching literature in a multidisciplinary environment. It is found that much relevant literature is not found because other disciplines use a different terminology, different units, or slightly different (but related) concepts. The paper suggests some approaches to enhance interdisciplinary understanding and improve exchange of ...

The incomplete perfect phylogeny (IPP) problem and the incomplete perfect phylogeny haplotyping (IPPH) problem deal with constructing a phylogeny for a given set of haplotypes or genotypes with missing entries. The earlier approaches for both of these problems dealt with restricted versions of the problems, where the root is either ...

Participatory and interdisciplinary approaches have been suggested to develop appropriate agricultural innovations as an alternative strategy to improve food security and well-being among HIV/AIDS affected households. However, sustainable implementation of such interactive approaches is far from easy and straight forward. This study reports of the Interactive Learning and Action (ILA) ...

Population nutrition problems have a diversity of contributory factors and, ideally, multi-sectoral solutions should be developed by the relevant stakeholders, based on a common understanding of these factors. The problem and solution tree approach is a participatory process of working through the layers of determinants and then developing potential interventions ...

It has been argued that the phenomenon of hormesis should prompt us to revise current regulatory policy in order to take beneficial effects of small doses of various agents into account. I argue that three problems--the comparative smallness of hormetic effects, the fine-tuning problem, and the problem of aggregated actions--should ...

Understanding the relationship between chemical structure and function is a ubiquitous problem within the fields of chemistry and biology. Simulation approaches attack the problem utilizing physics to understand a given process at the particle level. Unfortunately, these approaches are often too expensive for many problems of interest. Informatics approaches attack ...

Self-interaction is one of the most substantial problems in present-day density functional theory. A widely used approach to overcome this problem is the self-interaction correction proposed by Perdew and Zunger. However, the thus given functional not only depends on the orbitals explicitly but is also variant under unitary transformation of ...

The Farmer Life School (FLS) is an innovative approach to integrating HIV education into life skills and technical training for farmers. This study aims to gain insight into the strengths and weaknesses of this relatively new approach, through the implementation of an adapted version in South Africa. The results are ...

The world's grasslands and large migratory populations of wildlife have been disproportionately lost or disrupted by human activities, yet are poorly represented in protected areas. The major threats they face are land subdivision and the loss of large-scale dynamic processes such as wildlife migrations and fire. The large-scale dynamical processes ...

Using microphone arrays for estimating source locations and strengths has become common practice in aeroacoustic applications. The classical delay-and-sum approach suffers from low resolution and high sidelobes and the resulting beamforming maps are difficult to interpret. The deconvolution approach for the mapping of acoustic sources (DAMAS) deconvolution algorithm recovers the ...

During the last decades, Russia has developed regulations applying to the territories affected by radioactive contamination. Some regulatory approaches appear to be quite ineffective and contradictory. This paper shows by means of examples the problems and issues associated with some existing situations. A better way for the future is indicated.

In this article, an attempt is made to analyse important implications of the hermeneutic approach in qualitative studies. The article discusses the hermeneutic circle with regard to reasoning contexts, on which the researcher's interpretation is based. Problems in connection with achievement of 'proper' understanding in an interpretative process are discussed ...

An extension to the penalty alternating least squares (P-ALS) method, called multi-way penalty alternating least squares (NWAY P-ALS), is presented. Optionally, hard constraints (no deviation from predefined constraints) or soft constraints (small deviations from predefined constraints) were applied through the application of a row-wise penalty least squares function. NWAY P-ALS ...

Improved techniques for identifying active pathways in peripheral nerves using extraneural measurements would have numerous applications in the fields of neuroprostheses, neural system engineering, and diagnostics. In this study, we propose to approach this issue as an inverse problem of bioelectric source localization, using measurements from a multi-contact nerve cuff ...

Using filtered backprojection (FBP) and an analytic continuation approach, we prove that exact interior reconstruction is possible and unique from truncated limited-angle projection data, if we assume a prior knowledge on a subregion or subvolume within an object to be reconstructed. Our results show that (i) the interior region-of-interest (ROI) ...

Several features of currently used Bayesian methods in phylogenetic analysis are discussed. The distinction between Clade-Bayes and Topology-Bayes is presented and illustrated with an empirical example. Three problems with Bayesian phylogenetic methods--exaggerated clade support, inconsistently biased priors, and the impossibility of hypothesis testing of cladograms--are shown to be the result ...

This paper presents a volumetric formulation for the multi-view stereo problem which is amenable to a computationally tractable global optimisation using Graph-cuts. Our approach is to seek the optimal partitioning of 3D space into two regions labelled as "object" and "empty" under a cost functional consisting of the following two ...

The parabolic equation method is the most effective approach for solving range-dependent problems in ocean acoustics. During the past three decades, many difficulties have been encountered while attempting to generalize this approach to problems involving elastic layers. With the development of an improved single-scattering solution [J. Acoust. Soc. Am. 121, ...

An anterior tooth that is darkened due to intrinsic staining can be a severe esthetic problem. Current treatment involving crowns and opacious porcelain veneers have some inherent disadvantages in terms of tooth conservation and the final result. The latest innovation in composite resin allows a minimal intervention approach for correcting ...