Introduction: Little is known about the problems experienced by and the accommodation strategies used by computer users with rheumatoid arthritis (RA) or fibromyalgia (FM). This study (1) describes specific problems and accommodation strategies used by people with RA and FM during computer use; and (2) examines if there were significant ...

Incorporation of the PROJECT element for suppression of J modulation into the DEPT pulse sequence resulted in near-distortionless signals, thus realizing spectra more amenable to quantitative evaluation, a potential valuable aid in cases where (13)C-multilabeled compounds arise, e.g. as a result of feeding experiments in biosynthetic studies.

We investigate the computational complexity of inferring a smallest possible multilabeled phylogenetic tree (MUL tree) which is consistent with each of the rooted triplets in a given set. This problem has not been studied previously in the literature. We prove that even the very restricted case of determining if there ...

Identifying overlapping communities in networks is a challenging task. In this work we present a probabilistic approach to community detection that utilizes a Bayesian non-negative matrix factorization model to extract overlapping modules from a network. The scheme has the advantage of soft-partitioning solutions, assignment of node participation scores to modules, ...

Recently Liu et al. published a fast algorithm to solve the eigenvector problem arising in the quaternion-based method for the rotational superposition of molecular structures (J Comput Chem 2010, 31, 1561.). In this Comment, it is shown that the construction of the 4 × 4 matrix to be diagonalized—and not ...

Oral anticoagulation using vitamin K antagonists has been established for over 50 years. Although it is highly effective in preventing thromboembolic incidents, its therapeutic control still remains problematic. Therefore, a computer-aided approach is recommended for deriving dosages. Up to now, the dosage is often based on the visual inspection of ...

To analyze patient safety incidents associated with computer use to develop the basis for a classification of problems reported by health professionals. Incidents submitted to a voluntary incident reporting database across one Australian state were retrieved and a subset (25%) was analyzed to identify 'natural categories' for classification. Two coders ...

The fracture or defect of the mandibular condyle is one of the serious complications during angle-reduction ostectomy. Reconstruction of such defects also is a daunting task. The case report describes a method based on computer-aided design/computer-aided manufacturing (CAD/CAM) and rapid prototyping nanoscale hydroxyapatite/polyamide (n-HA/PA) for individual design, fabrication, and implantation ...

ABSTRACT Spinal orthoses are commonly prescribed to patients with moderate adolescent idiopathic scoliosis (AIS) for prevention of further curve deterioration. In conventional manufacturing method, plaster bandages are used to obtain the patient's body contour and then the plaster cast is rectified manually. With computer-aided design and computer-aided manufacture (CAD/CAM) system, ...

People exert large amounts of problem-solving effort playing computer games. Simple image- and text-recognition tasks have been successfully 'crowd-sourced' through games, but it is not clear if more complex scientific problems can be solved with human-directed computing. Protein structure prediction is one such problem: locating the biologically relevant native conformation ...

STUDY DESIGN: Development of a computer-aided Cobb measurement method and evaluation of its reliability. OBJECTIVES: To reduce the variability of Cobb angle measurement by developing the computer-aided method and to investigate if the developed method is sensitive to observer skill levels or experiences. SUMMARY OF BACKGROUND DATA: Therapeutic decisions for ...

PURPOSE: To develop a computer-aided diagnostic algorithm with automatic boundary delineation for differential diagnosis of benign and malignant breast lesions at ultrasonography (US) and investigate the effect of boundary quality on the performance of a computer-aided diagnostic algorithm. MATERIALS AND METHODS: This was an institutional review board-approved retrospective study with ...

Neural network computing demonstrates advanced analytical problem solving abilities to meet the demands of modern chemical research. (To listen to a podcast about this article, please go to the Analytical Chemistry multimedia page at pubs.acs.org/page/ancham/audio/index.html .).

The problem of generating uniform deterministic samples over the rotation group, SO(3), is fundamental to computational biology, chemistry, physics, and numerous branches of computer science. We present the best-known method to date for constructing incremental, deterministic grids on SO(3); it provides: 1) the lowest metric distortion for grid neighbor edges, ...

Recent developments in technology have revolutionized medicine and surgery. This article aims at providing an update on the current trends in computer-aided maxillofacial surgery and illustrates these advances with clinical cases. The PubMed database was searched for articles published during the past 5 years using the keywords "maxillofacial" and "surgery, ...

This article examines the differences among four in-office computer-aided design/computer-aided manufacturing restorative technologies. Two acquisition media systems, 3M ESPE's Lava COS and Cadent's iTero, are compared and contrasted. Additionally, two acquisition and manufacturing media, Sirona's CEREC AC and D4D's E4D, are examined. Image acquisition techniques and cast fabrication methodologies are ...

Searching for similar structures from a three-dimensional (3-D) structure database of proteins is one of the most important problems in post-genomic computational biology. To compare two structures, we ordinarily use a measure called the root mean square deviation (RMSD) as the similarity measure. We consider a very fundamental problem of ...

Computer-aided polyp detection aims to improve the accuracy of the colonography interpretation. The computer searches the colonic wall to look for polyplike protrusions and presents a list of suspicious areas to a physician for further analysis. Computer-aided polyp detection has developed rapidly in the past decade in the laboratory setting ...

In this article, we describe the function of computer-aided detection (CAD), the history of CAD in mammography, its current status, the differences between CAD in analog mammography and digital mammography, detection performance, and appropriate directions for its use.

OBJECTIVE: The purpose of this study was to investigate the accuracy and reproducibility of results acquired with computer-aided volumetry software during MDCT of pulmonary nodules exhibiting ground-glass opacity. MATERIALS AND METHODS: To evaluate the accuracy of computer-aided volumetry software, we performed thin-section helical CT of a chest phantom that included ...

Computer-aided detection (CAD) systems allow the automatic identification of lung nodules on chest computed tomography (CT), providing a second opinion to the radiologist's judgement and a volumetric evaluation of lesions - a very important aspect in oncological patients. The natural evolution of these systems has led to the introduction of ...

Therapies consisting of a combination of agents are an attractive proposition, especially in the context of diseases such as cancer, which can manifest with a variety of tumor types in a single case. However uncovering usable drug combinations is expensive both financially and temporally. By employing computational methods to identify ...

In the health system inefficiency leads to poor use of scarce expensive resources. Lengthy patient treatment waiting time can result from inefficiency in scheduling. The use of state-of-the art multi-agent and distributed computing technologies can provide a solution to address this problem. However, distributed optimisation in such a multi-agent setting ...

Edgar Codd's 1968 design for a self-replicating cellular automaton has never been implemented. Partly this is due to its enormous size, but we have also identified four problems with the original specification that would prevent it from working. These problems potentially cast doubt on Codd's central assertion, that the eight-state ...

Quadratic Unconstrained Binary Optimization (QUBO) problems concern the minimization of quadratic polynomials in n {0, 1}-valued variables. These problems are NP-complete, but prior work has identified a sequence of polynomial-time computable lower bounds on the minimum value, denoted by C(2), C(3), C(4),.... It is known that C(2) can be computed ...

This paper considers the use of autocorrelation properties to design zero reference codes (ZRCs) for optical applications. Based on the properties of the autocorrelation function, the design of an optimum ZRC problem is transformed into a minimization problem with binary variables, and the objective is to minimize the second maximum ...

Attacks on classic complex problem solving focus on both their ecological validity and the difficulty to analyze such a complex interplay of system variables. But we argue that the domain of travel planning is in some sense a much more "natural" domain and at least partially able to deal with ...

The purpose of this study was to evaluate the occlusion of all-ceramic onlay surfaces generated with a laboratory (LAB) and computer-aided design/computer-assisted manufacturing (COMP) system. The treatment of the mandibular left first molar was simulated on 16 casts. A minimum of three static contacts and their localization were defined beforehand ...

The search for the global minimum energy conformation (GMEC) of protein side chains is an important computational challenge in protein structure prediction and design. Using rotamer models, the problem is formulated as a NP-hard optimization problem. Dead-end elimination (DEE) methods combined with systematic A* search (DEE/A*) has proven useful, but ...

A practical method to tackle the sign problem in real-time path integral simulations is proposed based on the multilevel blocking idea. The formulation is made possible by using a cumulant expansion of the action, which in addition to addressing the sign problem, provides an unbiased estimator for the action from ...

Computer-aided diagnosis (CAD), in the general sense, includes computer-aided detection and characterization of abnormalities on medical images. The usefulness of CAD for assisting radiologists in detection of breast cancer in screening mammography has been demonstrated by a number of prospective clinical trials in recent years. The development of CAD in ...

Chest radiographs are the most common exam in radiology. They are essential for the management of various diseases associated with high mortality and morbidity and display a wide range of findings, many of them subtle. In this survey we identify a number of areas beyond pulmonary nodules that could benefit ...

Computer-aided surgery lets you visualize the position of instruments and implants during procedures. It improves surgical accuracy and enhances capabilities in areas where direct visibility is limited. How does the technology work, and how might it affect your budget?

We study constraint satisfaction problems on the so-called planted random ensemble. We show that for a certain class of problems, e.g., graph coloring, many of the properties of the usual random ensemble are quantitatively identical in the planted random ensemble. We study the structural phase transitions and the easy-hard-easy pattern ...

Meta-analysis can be valuable if it heeds its originators' caution that intimate communing with the data is essential. A critique of the authors' own meta-analysis shows that the danger of overly broad conclusions could be reduced by attention to specificities and awareness of potentially hidden sources of variance. Conclusions from ...

OBJECTIVE: To describe the prevalence of computer use problems experienced by a sample of people with arthritis, and to determine differences in the magnitude of these problems among people with rheumatoid arthritis (RA), osteoarthritis (OA), and fibromyalgia (FM). METHODS: Subjects were recruited from the Arthritis Network Disease Registry and asked ...

Computer modeling and computer auralization will produce comparative listening experiences for architects, building owners, and building users based on selected interior surface shapes, interior finish materials, and electroacoustic sound distribution. Auralization can be a significant tool in helping building designers, owners, and users understand potential acoustical problems and the need ...

Journal of Computer-Aided Molecular Design Vol.23 Nr.4, 227 - 239

Advanced ceramic materials such as zirconia have great potential as substitutes for traditional materials in many biomedical applications. Since the end of the 1990s, the form of partially stabilized zirconia has been promoted as suitable for dental use due to its excellent strength and superior fracture resistance as result of ...

A continuous location problem in which a firm wants to set up two or more new facilities in a competitive environment is considered. Other facilities offering the same product or service already exist in the area. Both the locations and the qualities of the new facilities are to be found ...

In this work we study a phylogeny problem. That is, given a collection of organisms, we want to reconstruct the evolutionary history of the organisms. We are interested in inferring relationships between the organisms. For a number of reasonable biological hypotheses the problem becomes NP-hard. Besides that, the problem data ...

Advances in multidetector CT (MDCT) scanners have increased the pace of development of advanced postprocessing applications, such as virtual endoscopy (VE), segmentation and volumetry, and computer-aided postprocessing methods. Availability of thin-section MDCT data sets of isotropic voxel resolution ensures accuracy in structure segmentation, which is an important initial prerequisite on ...

ABSTRACT: BACKGROUND: The Hamiltonian Path Problem asks whether there is a route in a directed graph from a beginning node to an ending node, visiting each node exactly once. The Hamiltonian Path Problem is NP complete, achieving surprising computational complexity with modest increases in size. This challenge has inspired researchers ...

Basety is a French semantic database of exemplars of 21 categories of objects, with a typicality index associated with each exemplar. These 21 semantic categories are animals, trees, weapons, buildings, flowers, fruits, insects, instruments of music, games, toys, vegetables, mammals, furniture, birds, tools, fish, occupation, containers, sports, vehicles, and clothes. ...

This paper proposes a new sequential weighted least squares (SWLS) method for positron emission tomography (PET) reconstruction. The SWLS algorithm is noniterative and can be considered as equivalent to the penalized WLS (PWLS) method under certain initial conditions. However, a full implementation of SWLS is computationally intensive. To overcome this ...

A method is proposed which allows to efficiently treat elliptic problems on unbounded domains in two and three spatial dimensions in which one is only interested in obtaining accurate solutions at the domain boundary. The method is an extension of the optimal grid approach for elliptic problems, based on optimal ...

Based on the concepts and principles of quantum computing, a novel immune clonal algorithm, called a quantum-inspired immune clonal algorithm (QICA), is proposed to deal with the problem of global optimization. In QICA, the antibody is proliferated and divided into a set of subpopulation groups. The antibodies in a subpopulation ...

OBJECTIVE: To compare the accuracy of 3 computer-aided surgery systems for maxillofacial reconstruction. DESIGN: Evaluation of 3 computer-aided surgery systems: StealthStation, VectorVision, and Voxim. SETTING: The University of California, Davis, Department of Otolaryngology computer-aided surgery laboratory. PARTICIPANTS: Four fresh cadaveric heads. MAIN OUTCOME MEASURE: Mean target registration error. RESULTS: The ...

BACKGROUND: The sensitivity of screening mammography for the detection of small breast cancers is higher when the mammogram is read by two readers rather than by a single reader. We conducted a trial to determine whether the performance of a single reader using a computer-aided detection system would match the ...

An analogy between the evolution of organisms and some complex computational problems (cryptosystem cracking, determination of the shortest path in a graph) is considered. It is shown that in the absence of a priori information about possible species of organisms such a problem is complex (is rated in the class ...