Search Results
Results 451 - 500 of 1360
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Singal Archana - - 2005
Localized tinea cruris and tinea corporis can be treated by topical imidazoles (clotrimazole) or newer topical agents like butenafine, a benzylamine derivative with fungicidal activity. The therapeutic efficacy of these two agents was compared in this study. Eighty patients, diagnosed clinically to have tinea cruris or localized tinea corporis and ...
Singla Rupak - - 2005
OBJECTIVE: To study the influence of initial bacillary load on sputum conversion rates and treatment outcome of new smear positive pulmonary tuberculosis patients. METHODS: A retrospective study was done among 2938 new smear positive pulmonary tuberculosis patients, registered at the peripheral centres, covering a population of 1.6 million in Delhi, ...
Khichi Qasim Khan - - 2005
OBJECTIVE: To analyze the clinical presentation, treatment given, and outcome of patients suffering from congenital and acquired malaria in neonatal period. DESIGN: Analytical study. PLACE AND DURATION OF STUDY: Paediatrics Ward-2, QAMC/BVH, Bahawalpur for 02 years from October 2001 to October 2003. PATIENTS AND METHODS: The study included 45 cases ...
Ohanu, ME; Department of ...
Aim: To determine any relationship between Malaria infections and Widal agglutinin level. Patients and Methods: Three hundred and thirty adult patients attending various clinics at University Of Nigeria Teaching Hospital between September 2000 and May 2001 first confirmed of malaria parasitaemia also had Widal agglutinin levels checked. Similar thing was ...
Okafor, Henrietta U; Department ...
Objective: To determine and compare the in vivo efficacy of the trial drugs chloroquine and sulphadoxine-pyrimethamine in the treatment of uncomplicated malaria in under 5 children. Study Design and Methods: This was a comparative clinical trial conducted at Ugwuogo Nike, a rural community, in South east Nigeria. Patients were selected ...
Esamai F - - 2005
The treatment of patients with severe malaria in sub-Saharan Africa has become a challenge to clinicians due to poor compliance to quinine and the increasing multidrug resistance to antimalarials by the P. falciparum parasite. The aim of this study was to compare the efficacy and safety profile of two truncated ...
Valencia I - - 2004
Relapse of herpes simplex virus (HSV) encephalitis following acyclovir therapy has been reported infrequently in children beyond the neonatal period. The pathogenic mechanism of the recurrence is not fully understood. We report two new cases that support a mechanism of latent HSV infection with reactivation of the disease. Our patients ...
Subasi Mehmet - - 2004
Skeletal tuberculosis (TB) is less common than the pulmonary form. Involvements of the metacarpals and phalanges of the hand are infrequent. The authors report their experience with treatment and outcome of TB of the metacarpals and phalanges of the hand in 7 patients. There were 4 women and 3 men ...
Dodor E A - - 2004
Effia-Nkwanta Regional Hospital, located at Sekondi-Takoradi, the capital and third largest city of the Western Region of Ghana. To examine factors associated with treatment default among tuberculosis (TB) patients registered for treatment in 2000-2001. Retrospective review of institutional records of TB patients. The database for registered TB patients was sorted ...
Disch Jolande - - 2004
With the aim of evaluating the utility of the detection of Leishmania kDNA in peripheral blood for the cure assessment of visceral leishmaniasis (VL), a PCR based method was performed in patients with confirmed VL at three follow-up periods after specific chemotherapy with pentavalent antimonial. In 16 out of 17 ...
Johnson J L - - 2004
Controlled trials have failed to show an effect of Mycobacterium vaccae immunotherapy on treatment outcome and mortality in patients with tuberculosis (TB); however, several studies have suggested improvement in radiographic clearing and resolution of cavitary disease. To assess the effect of M. vaccae immunotherapy on radiographic healing in pulmonary TB, ...
Calandra Thierry - - 2004
Invasive mycoses have emerged as a major cause of morbidity and mortality. Epidemiological studies have shown that surgery services have the highest rate of Candida infections in the hospital. In addition to classical risk factors, heavy Candida colonization, recurrent gastrointestinal perforations, and acute pancreatitis are frequently associated with invasive candidiasis. ...
Adam I - - 2004
The efficacies of several antimalarial drugs in the treatment of uncomplicated Plasmodium falciparum malaria were compared, during an open, randomized trial, in New Halfa, eastern Sudan. The 96 patients who completed the 28 days of follow-up were treated with chloroquine (N = 26), sulfadoxine-pyrimethamine (N = 38) or quinine (N ...
Tattevin P - - 2004
Until recently, brain aspergillosis was almost always fatal, with a response rate to amphotericin B of < 10%. This study describes a retrospective analysis of eight consecutive cases of brain aspergillosis. All patients were immunosuppressed and five required mechanical ventilation. Antifungal treatment included amphotericin B (n = 7), itraconazole (n ...
Jimmy, EO; Department of ...
In vitro drugs test with WHO micro test method was used to compare the efficacy of four antimalarials: Chloroquine, Fansidarâ, Cotecxinâ and Amalarâ on isolates of plasmodium malaria. A three-day (72 hrs) incubation period for drugs-parasites interactions was used. Thirteen (13) patients with chloroquine treatment had no complete parasite clearance ...
Borrmann Steffen - - 2004
It has been demonstrated that fosmidomycin has good tolerability and rapid onset of action, but late recrudescences preclude its use alone; in vitro, clindamycin has been shown to act synergistically with fosmidomycin against Plasmodium falciparum. We conducted a study in pediatric outpatients with P. falciparum malaria in Gabon to evaluate ...
HEATHER M. SWANSON
We present information on the breeding biology and nest-site characteristics of the western subspecies of the Chipping Sparrow (Spizella passerina arizonae) in montane ponderosa pine (Pinus ponderosa) forests of the Colorado Front Range. We located 83 nests during the summers of 1999–2002. The earliest egg date was 23 May and ...
Siddiqui Arshad A - - 2004
OBJECTIVE: Craniocerebral aspergillosis of sinonasal origin has been reported mainly in immunocompromised patients with high mortality, and it has been described very infrequently in immunocompetent hosts. This retrospective study focuses on clinical outcome in relation to anatomic locations of invasive aspergillosis of sinonasal origin in immunocompetent patients with emphasis on ...
Calvopina Manuel - - 2004
BACKGROUND: A well-tolerated oral drug is required for the treatment of mucocutaneous leishmaniasis (MCL). Current parenteral treatment regimens with pentavalent antimonials are associated with marked toxicity and significant rates of relapse. AIM: To evaluate the efficacy and tolerability of high-dose itraconazole for the treatment of MCL. METHODS: An uncontrolled treatment ...
Sobel Jack D - - 2004
BACKGROUND: No safe and convenient regimen has proved to be effective for the management of recurrent vulvovaginal candidiasis. METHODS: After inducing clinical remission with open-label fluconazole given in three 150-mg doses at 72-hour intervals, we randomly assigned 387 women with recurrent vulvovaginal candidiasis to receive treatment with fluconazole (150 mg) ...
Nuermberger Eric L - - 2004
In a recent experimental study using the mouse model of tuberculosis, treatment with a combination of rifampin, moxifloxacin, and pyrazinamide was able to shorten the time to negative lung cultures by up to 2 months compared with the standard regimen of rifampin, isoniazid, and pyrazinamide. To confirm that this substitution ...
Vaughan-Williams, CH; Medical Manager, ...
Background; A study, which included a follow-up study, was undertaken to assess the efficacy of CoartemTM tablets (20 mg artemether and 120 mg lumefantrine – Novartis South Africa (Pty) Ltd) to clear <I>plasmodium falciparum</I> malaria parasitaemia at a single 42-day follow-up, with 42 days being chosen in order to detect ...
Ogbonnaya, Lawrence U; Department ...
Setting: The chest clinic of the University of Nigeria Teaching Hospital, Enugu Nigeria, the main referral tuberculosis treatment centre for Enugu and its environs. Objective: To compare the efficacy of home-based lay worker supervised DOTS with facility based health worker supervised DOTS during the intensive phase. Design: 600 consecutive newly ...
Nateniyom S - - 2004
SETTINGS: Sixteen prisons located in four geographic regions in Thailand. OBJECTIVES: To assess treatment outcomes of tuberculosis (TB) patients under the DOTS strategy in a prison programme. METHOD: The programme prospectively included 1412 consecutive TB patients registered during Year 1 (June 1999-May 2000), Year 2 (June 2000-May 2001) and Year ...
Sanmano B - - 2004
BACKGROUND: Terbinafine, based on its pharmacokinetic properties, is a good candidate for pulse therapy. There are, as yet, no current guidelines for a terbinafine 1-week pulse regimine. OBJECTIVE: To determine the optimal 1-week pulse dosing regimen for combination therapy of oral terbinafine with complementary 1% terbinafine cream for the treatment ...
Steinbach William J - - 2004
Current in vitro and in vivo data indicate that invasive aspergillosis due to Aspergillus terreus is resistant to treatment with amphotericin B. Because little clinical data are available to guide therapy, we performed a retrospective cohort study of cases of invasive A. terreus infections from 1997-2002 to determine whether the ...
Jasmer Robert M - - 2004
Effective treatment of tuberculosis requires adherence to a minimum of 6 months treatment with multiple drugs. To improve adherence and cure rates, directly observed therapy is recommended for the treatment of pulmonary tuberculosis. We compared treatment outcomes among all culture-positive patients treated for active pulmonary tuberculosis (n = 372) in ...
Zaias Nardo - - 2004
BACKGROUND: The standard treatment of Trichophyton rubrum nail bed onychomycosis (or distal subungual onychomycosis [DSO]) with daily terbinafine for 12 weeks involves treating for a fixed period shorter than the time required for complete replacement of the nail bed and overlying nail plate by normal growth. The same total amount ...
Santha T - - 2004
OBJECTIVE: To evaluate the efficacy of split-drug regimens for treatment of patients with sputum smear-positive pulmonary tuberculosis in south India. DESIGN: Randomized controlled clinical trial where eligible patients were randomly allocated to: (i) 2RE(3)HZ(3)(alt)/4RH(2) (split I): rifampicin plus ethambutol given on one day and isoniazid plus pyrazinamide the next day ...
Asilian A - - 2004
BACKGROUND: Cutaneous leishmaniasis (CL) is a parasitic disease caused by Leishmania species. There is a need for more effective and less time-consuming therapeutic methods for this condition. AIM: To evaluate the efficacy of combined cryotherapy and intralesional meglumine antimoniate (MA) (Glucantime, Specia, Paris, France) for the treatment of CL. METHODS: ...
Hübel K - - 2004
Severe fungal infections remain a significant cause of morbidity and mortality in neutropenic patients undergoing dose-intensive chemotherapy for malignant diseases. Chronic disseminated candidiasis (CDC) is a life-threatening complication in neutropenic patients because of the lack of responsive hematopoietic precursor cells. Resolution of Candida organ lesions after hematopoietic reconstitution may take ...
- - 2004
(1) The reference treatment for invasive candidiasis in patients without neutropenia is standard amphotericin B. If this treatment fails or is too nephrotoxic, second-line alternatives are liposomal amphotericin B and fluconazole. Voriconazole is a third-line option. (2) Caspofungin, an antifungal drug belonging to the echinocandin class, is now approved for ...
Pukrittayakamee Sasithon - - 2004
The activities of primaquine in combination with quinine or artesunate against asexual- and sexual-stage parasites were assessed in 176 adult Thai patients with uncomplicated Plasmodium falciparum malaria. Patients were randomized to one of the six following 7-day oral treatment regimens: (i) quinine alone, (ii) quinine with tetracycline, (iii) quinine with ...
Gupta A K - - 2004
BACKGROUND: Onychomycosis is a common nail disease that is often chronic, difficult to eradicate, and has a tendency to recur. The most common oral therapies for dermatophyte toenail onychomycosis include terbinafine, itraconazole and fluconazole. OBJECTIVES: A cumulative meta-analysis of the randomized controlled trials (RCTs) for antimycotic agents was performed to ...
Conaty S J - - 2004
In January 2002 the Communicable Disease Surveillance Centre (CDSC) introduced outcome reporting for tuberculosis 12 months after start of treatment. To determine whether outcome could change with longer and more detailed follow up, we examined this at 12 months and two years for a cohort notified in 2000 at a ...
Ojuawo, A; ;
Background: Diarrhoeal disease remains a leading cause of morbidity and mortality in childhood. The advent of oral rehydration therapy (ORT) including home treatment of diarrhoea has affected the incidence of dehydration. Objective: To assess the impact of oral rehydration therapy on childhood diarrhoeal disease. Design: Cross sectional study. Methods: The ...
ZUREN ZHOU
The Artinskian Metaperrinites and Kungurian Perrinites faunas are recognized from the Ratburi Group of the Loei area, northcentral Thailand, and the Saraburi Group of the Saraburi area, southcentral of the country, respectively. They represent one of the chains of the Asia-European perrinitid belt that was distributed within the ancient Tethys ...
Avila Juan Carlos - - 2004
We assessed the efficacy of mefloquine monotherapy and mefloquine-artesunate (MQ-AS) combination therapy for the treatment of Plasmodium falciparum malaria at four sites in the Bolivian Amazon region. Patients with uncomplicated P. falciparum infections between 5 and 60 years of age were randomly assigned to be treated with either MQ (15 ...
Kobashi Yoshihiro - - 2004
We aimed to investigate the transitional pattern of the clinical features of pulmonary Mycobacterium-avium complex (MAC) disease, especially with regard to the clinical effect of treatment, in patients treated before and after the implementation of the 1998 guidelines of the Japanese Society for Tuberculosis for combined chemotherapy for pulmonary MAC ...
Drew Richard H - - 2004
BACKGROUND: Aerosolized administrations of amphotericin B deoxycholate (AmBd) and amphotericin B lipid complex (ABLC) in lung transplant recipients were compared for safety and tolerability. The incidence of invasive fungal infections in patients receiving aerosolized amphotericin B formulations as sole prophylaxis was determined. METHODS: A prospective, randomized (1:1), double-blinded trial was ...
Chan Edward D - - 2004
Multidrug-resistant tuberculosis, a disease caused by Mycobacterium tuberculosis strains that are resistant at least to rifampin and isoniazid, entails extended treatment, expensive and toxic regimens, and higher rates of treatment failure and death. We retrospectively analyzed the outcomes in 205 patients treated at our center for multidrug-resistant tuberculosis, with strains ...
Vijay B. Nagpal, V.K. ...
Introduction: Both topical and systemic ketoconazole are reported to be effective against pityriasis versicolor. Material and Methods: Forty patients suffering from pityriasis versicolor were treated either with oral ketoconazole 200 mg per day or 2% ketoconazole cream topically once daily for 2 weeks. Results: On global assessment, after 2 weeks ...
Toungoussova O S - - 2004
The objective of this study was to evaluate the outcome of treatment of culture-positive cases of tuberculosis registered in Archangel, Russia, in 1999, and to analyse the influence of Mycobacterium tuberculosis drug resistance on treatment outcome. The outcome of tuberculosis treatment was evaluated for 235 new and 61 previously treated ...
Negroni Ricardo R Mycology Unit, Francisco Javier Muñiz Infectious Diseases Hospital, Buenos Aires, Argentina. - - 2004
A 41-year-old woman with no known immunosuppression experienced a 12-year period of a relapsing phaeohyphomycosis. Despite administration of multiple courses of therapy with standard antifungals, sustained clinical remission was not achieved. A partial response was seen initially with the combination of itraconazole and flucytosine therapy, but the patient did not ...
Baysal Vahide - - 2004
BACKGROUND: Due to the high rate of recurrence, seborrheic dermatitis (SD) represents a therapeutic problem. AIM: To evaluate the role of oral itraconazole in the treatment of SD. PATIENTS AND METHODS: Thirty-two patients with SD were enrolled in the study. All topical and oral treatments were stopped. The patients applied ...
Schwartz S - - 2004
In aspergillus infections of the central nervous system (CNS) the mortality risk usually exceeds 90%. Data from case-reports and a recent retrospective study suggest that neurosurgical interventions, such as abscess resections, stereotactic drainages, or the use of intraventricular catheters, might improve the outcome in CNS aspergillosis. However, there is a ...
Wark P A B - - 2004
Allergic bronchopulmonary aspergillosis is hypersensitivity to the fungus Aspergillus fumigatus that complicates patients with asthma and cystic fibrosis. The mainstay of treatment for allergic bronchopulmonary aspergillosis remains oral corticosteroids, though this does not completely prevent exacerbations and may not prevent the decline in lung function. The purpose of this review ...
Bhattacharya Sujit K - - 2004
Miltefosine has previously been shown to cure 97% of cases of visceral leishmaniasis (VL) in Indian adults. Because approximately one-half of cases of VL occur in children, we evaluated use of the adult dosage of miltefosin (2.5 mg/kg per day for 28 days) in 80 Indian children (age, 2-11 years) ...
Baden L R - - 2003
BACKGROUND: Invasive fungal infections (IFI), particularly those caused by Aspergillus and other angioinvasive molds, are associated with an excessive mortality despite therapy. METHODS: Voriconazole was prescribed on a compassionate basis to patients with IFI who were intolerant to or who had progressed despite standard therapy. Outcome was determined by protocol-based ...
Cohen A D - - 2003
BACKGROUND: Previously, sponsored publications have shown that either terbinafine or itraconazole (pulse regimen) are effective for patients with toenail onychomycosis. However, independent comparative studies are lacking. OBJECTIVES: To objectively compare treatment with terbinafine and itraconazole in patients with toenail onychomycosis. METHODS: The effectiveness of terbinafine (250 mg/day 3 months) versus ...
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