Search Results
Results 251 - 300 of 1813
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Demirci Hakan - - 2010
To evaluate the efficacy of topical imiquimod 5%, a local immune response modifier, in the treatment of periocular lentigo maligna. Retrospective, interventional case series. Five consecutive patients with biopsy-proven periocular lentigo maligna. Periocular lentigo maligna was treated with topical imiquimod 5%. The clinical features, treatment schedule, response to treatment, and ...
Roongpisuthipong Anuvat - - 2010
OBJECTIVE: To describe the treatment pattern of condyloma acuminata in female. MATERIAL AND METHOD: The 5-year medical records of 449 women treated for genital condyloma acuminata at the Gynecologic Infectious Diseases and Female Sexually Transmitted Disease (GID-FSTD) unit were reviewed. Data included the distribution of age, client by category, anatomical ...
Van Meurs Tim - - 2010
BACKGROUND: The first choice of treatment for lentigo maligna (LM) is excision. Initial studies of treatment with imiquimod 5% cream have shown promising results with excellent cosmetic outcome, but the follow-up duration in these studies was short. OBJECTIVES: To evaluate the results of treatment of patients with LM with imiquimod ...
Haider Kathryn M - - 2010
BACKGROUND: Propranolol has recently been reported to be useful in the treatment of infantile hemangiomas. However, there are still many questions regarding the dosage, duration, and method of delivery. METHODS: In this retrospective, observational case series, all patients had complete eye examinations and were found to have vision-threatening hemangiomas. All ...
Kwah Yung-Chien - - 2010
Treatment for progressive macular hypomelanosis (PMH) has been disappointing. Recently, Propionibacterium acnes had been postulated as the causative agent and narrow-band ultraviolet B (NBUVB) had been shown to stimulate melanogenesis and has antibacterial properties. The aim of this study was to evaluate the effectiveness of NBUVB in the treatment of ...
Baldo A - - 2010
The treatment of mild-moderate acne with topical drugs in association with appropriate cosmetics is currently the golden standard. The tolerability and efficacy of a cream formulated with a new mix of alpha-hydroxy acids (Hyseac AHA cream) in 248 patients with mild-moderate acne (comedonic, inflammatory, or mixed) have been investigated in ...
Quirk Christopher - - 2010
We conducted a prospective, multicenter, phase 3, open-label study to assess long-term sustained clearance of superficial basal cell carcinomas (sBCCs) treated with imiquimod cream 5%. A biopsy-confirmed tumor (area > or = 0.5 cm2 and diameter < or = 2.0 cm) was treated once daily 7 times per week for ...
Eichenfield Lawrence F - - 2010
OBJECTIVES: The goals were to assess the degree of improvement of facial acne after treatment with the 0.04% tretinoin microsphere gel (TMG) among patients 8 to 12 years of age and to assess tolerability and safety. METHODS: An open-label study was conducted with 40 patients 8 to 12 years of ...
Torres Sheila M F - - 2010
Aural plaques affect at least 22% of horses and can be asymptomatic or cause ear sensitivity. Immunohistochemical and electron microscopy studies have shown a strong association between aural plaques and papilloma virus. The purpose of this study was to investigate the efficacy of imiquimod 5% cream, an immune response modifier ...
Gamil Hend - - 2010
BACKGROUND: Treatment of plantar warts represents a continuing challenge for dermatologists because many of the available therapeutic modalities are associated with unsatisfactory results and high recurrence rates. Several clinical trials have proved the efficacy of intralesional immunotherapy by different antigens in the treatment of different types of warts. OBJECTIVE: To ...
Farmaki Rania - - 2010
This study was designed to investigate the presence and density of domestic mites (DMs) in households with atopic dogs sensitive to these mites (group A; n=20), in households with clinically healthy, nonatopic dogs (group B; n=20) and in households without pets (group C; n=25). Dust samples were vacuum-collected from the ...
Poulin Yves - - 2010
We evaluated in this study the efficacy and safety of an alternate regimen using clobetasol propionate 0.05% shampoo (CP shampoo) for long-term control of scalp psoriasis. Patients with moderate scalp psoriasis (Global Severity Score [GSS] of 3 on a 0-5 scale) first received CP shampoo once daily for 4 weeks. ...
Ma Ying - - 2010
BACKGROUND: Previous studies have demonstrated the efficacy and safety of tacrolimus ointment in the treatment of atopic dermatitis (AD); however, few have investigated the effect of tacrolimus on chronic actinic dermatitis (CAD). OBJECTIVES: To investigate the efficacy and safety of tacrolimus ointment on CAD and its mechanism of treatment. METHODS: ...
Choi Yu Sung - - 2010
BACKGROUND: Acne treatments are sometimes expensive, and mild acne patients need some simpler form of treatment and, thus, the need for easier and cheaper ways of managing acne is increasing. METHODS: An 8-week, double-blind, randomized clinical trial was conducted to determine whether cleansers are effective at producing clinical improvements in ...
Harper Julie C - - 2010
Benzoyl peroxide (BPO) is a commonly used and highly effective topical treatment for acne that is available in concentrations from 2.5-10%. The compound is not associated with bacterial resistance, and published acne treatment guidelines recommend BPO in conjunction with the long-term use of both topical and systemic antibiotics. A number ...
Siller Greg - - 2010
To evaluate the safety of two applications of PEP005 (ingenol mebutate) gel in superficial basal cell carcinoma. Efficacy was a secondary end-point. Randomized, vehicle-controlled, phase IIa study conducted at eight private dermatology clinics in Australia. A total of 60 patients with histologically confirmed superficial basal cell carcinoma (lesion size, 4-15 ...
Yuqi Tony Tang - - 2010
The standard treatment of prurigo nodularis (PN) includes antihistamines, ultraviolet light, and topical and systemic corticosteroids; unfortunately, PN is notoriously resistant to the conventional therapy. Herewith is described one case of PN, which was initialized with herose as the first-line therapy resulting in complete clinical clearance. Results of follow-up examinations ...
Köse Osman - - 2010
BACKGROUND: With regard to the lack of effective treatment modalities for childhood localized vitiligo, the search for newer therapeutic agents continues. OBJECTIVE: To conduct an open, comparative trial to evaluate the clinical efficacy and safety of topical mometasone cream and pimecrolimus cream in the treatment of childhood vitiligo. METHODS: Fifty ...
Meurer Michael - - 2010
BACKGROUND: Pimecrolimus and topical corticosteroids (TCS) combination therapy may provide an alternative treatment for patients with severe atopic dermatitis (AD), with faster clearance of disease flares, consequently reducing the duration of TCS treatment. OBJECTIVE: To assess the safety profile of pimecrolimus cream 1% combined with fluticasone versus fluticasone alone in ...
Shoimer I - - 2010
An actinic keratosis (AK) is a pre-malignant cutaneous lesion that frequently manifests in sun-exposed areas of the skin as a small, rough, scaly erythematous papule. They are one of the most common presenting complaints for dermatologists. AKs should be treated due to their potential to progress into a squamous cell ...
Seo Sang-Hee - - 2010
Although molluscum contagiosum (MC) resolves spontaneously, there are several reasons to treat this dermatological disorder. To evaluate the safety and efficacy of 5% imiquimod cream versus 10% potassium hydroxide (KOH) solution in treating MC, and to propose the mechanism of cure by observing the histological findings. Imiquimod or KOH were ...
Stough Dow - - 2010
This prospective 18-month, open-label, multicenter study assessed the long-term safety and efficacy of fluorouracil cream 0.5% in 277 participants with multiple actinic keratoses (AKs) on the face/anterior scalp and other body sites. Two treatment/observation cycles were separated by 12 months. During treatment cycle 1 (TC1), all participants were treated with ...
Pavesi Vanessa C S - - 2011
Oral mucositis is a common complication in the treatment of cancer. Its management and prevention are seen as high priority in cancer patient care. The aim of the present study was to investigate the effect of topical chamomile in the treatment of oral mucositis induced by 5-fluoracil (5-FU) in hamsters. ...
Grimes Pearl E - - 2010
BACKGROUND: Melasma is often recalcitrant to treatment. Triple combination (TC) cream is an effective and approved treatment for melasma. OBJECTIVE: We sought to determine the efficacy and safety of continuous therapy followed by a maintenance treatment regimen during a period of 24 weeks with a TC cream containing hydroquinone 4%, ...
Roberts Janet L - - 2010
Safety and efficacy of up to 3 courses of alefacept intramuscular (IM) in the treatment of chronic plaque psoriasis have been demonstrated in earlier trials. We sought to determine the safety and efficacy of up to 5 courses of alefacept IM in treating plaque psoriasis. A standard treatment course was ...
Trelles Mario A - - 2010
BACKGROUND: Melasma is a difficult entity to treat. Topical creams or chemical peels offer some success, and the newer fractional lasers have also been proposed to be useful. This three-armed study compares topical creams, CO2 ablative fractional resurfacing and the combination of both modalities. PATIENTS AND METHODS: Thirty females with ...
Carlesimo M - - 2010
An association between psoriasis and cardiovascular diseases has been reported, and treatment of this condition is often considered difficult because the conventional systemic therapies often show several side effects. To assess the efficacy and tolerability of a new drug, folinate calcium, to treat psoriasis, a total of 58 patients affected ...
Vähävihu K - - 2010
Narrowband ultraviolet B (NB-UVB) is a routine treatment for psoriasis and atopic dermatitis (AD) but its effect on vitamin D balance is not well studied. To examine whether NB-UVB treatment in winter improves vitamin D balance in psoriasis and AD, and to study the effects of NB-UVB on antimicrobial peptide ...
Kemény L - - 2010
One of the major technological breakthroughs in the last decade is represented by the diversified medical applications of light-emitting diodes (LEDs). LEDs emitting in the ultraviolet (UV) B spectrum might serve as a more convenient alternative for targeted delivery of phototherapy in inflammatory skin diseases such as psoriasis. We investigated ...
Choi J W - - 2010
Background  Facial psoriasis gives rise to considerable concern because of associated cosmetic problems and psychosocial distress. It requires a treatment approach other than topical corticosteroids, which bear a risk of cutaneous adverse reactions. Recently, topical tacalcitol has been shown to be effective in psoriasis. Objectives  The aim of this open-label ...
Dölle S - - 2010
The complex pathogenesis of atopic dermatitis (AD) is guided by cell surface receptor-mediated signal transduction regulated in lipid rafts. Miltefosine is a raft-modulating molecule targeting cell membranes. With this controlled clinical study, the clinical and immunomodulatory efficacy of miltefosine was investigated in patients with AD in comparison with a topical ...
Millikan Larry E - - 2010
There presently exists a wide selection of choices in the treatment of superficial mycoses. The main categories of broad-spectrum agents are the allylamines and imidazoles, which have been tried and proven over more than 2 decades of usage with good safety. Nystatin and griseofulvin have even longer experience of about ...
Mathes Erin F D - - 2010
Molluscum contagiosum is very common. In this article we discuss the use of cantharidin as a treatment option for molluscum contagiosum and give detailed information about distribution sources, how to apply it, and caveats regarding its use.Molluscum contagiosum is a common viral disease of childhood caused by a poxvirus, which ...
Fourie J J - - 2010
The objective of this study was to determine the therapeutic and residual efficacy of a topically applied combination of cyphenothrin (40%) and pyriproxyfen (2%) against the tick Haemaphysalis elliptica and the flea Ctenocephalides felis on dogs. Twelve dogs were infested with 50 ticks 2 days before they were treated and ...
Carneiro Rachel Camargo - - 2010
The objective of this pilot study was to evaluate the efficacy and safety of 5% imiquimod cream in the treatment of periocular basal cell carcinoma (BCC) through the analysis of a case series. Eight subjects with primary nodular BCC of the eyelid were recruited. Treatment lasted 10 to 16 weeks. ...
Orringer Jeffrey S - - 2010
BACKGROUND: There remains the need for more effective therapeutic options to treat acne vulgaris. Interest in light-based acne treatments has increased, but few randomized, controlled clinical trials assessing the value of photodynamic therapy (PDT) for acne have been reported. AIMS: We sought to examine the efficacy of PDT using 5-aminolevulinic ...
Sadick Neil - - 2010
Recent advances in light therapy coupled with photosensitizers offer alternatives to topical creams and gels and systemic oral agents for acne treatment. To examine the safety and efficacy of the photosensitizer 5-aminolevulinic acid (ALA) in patients with moderate-to-severe acne, a randomized, split-face study, using ALA on one side of the ...
Takahashi María Denise - - 2010
INTRODUCTION: Plaque-type psoriasis affecting the nails, scalp, hands or feet can often be difficult to treat; for example, topical treatments and phototherapy may not penetrate the nail plate or scalp. The objective of this large, international, multicentre study was to investigate the efficacy of efalizumab in a Latin American population ...
Abramovits William - - 2010
Only a few corticosteroids for topical use have proven safe and effective in pediatric populations down to 3 months of age. The authors report the results of a study designed to assess the efficacy and safety of hydrocortisone butyrate (HCB) 0.1% in lipocream (LCr) vehicle in infants and children. A ...
Mandelin Johanna - - 2010
A one-year, randomized, double-blind study was conducted in 80 patients with atopic dermatitis treated with tacrolimus ointment or a corticosteroid regimen (hydrocortisone acetate 1% ointment for head and neck, hydrocortisone butyrate 0.1% ointment for trunk and limbs) to compare efficacy and safety, and effects on Th2-reactivity. The study was completed ...
Lotti Torello - - 2010
OBJECTIVES: To evaluate the efficacy and safety of efalizumab in continuous or interrupted therapy of adults with moderate-to-severe plaque psoriasis who had failed to respond to or were intolerant of other systemic therapies, including methotrexate, ciclosporin and psoralen plus UVA phototherapy, or for whom such therapies were contraindicated. METHODS: Patients ...
Wang Xiu-Li - - 2010
OBJECTIVES: To evaluate the effectiveness of topical 5-aminolevulinic acid (ALA)-medicated photodynamic therapy (PDT) for the treatment of severe acne vulgaris. METHODS: A total of 78 Chinese patients with Grade 4 severe facial acne were treated with 1-3 courses of ALA PDT. ALA cream (10%) was applied topically to acne lesions ...
Shemer A - - 2010
Tinea pedis is a common skin disease affecting most of the population during their lifetime. Topical and systemic treatments give only temporary relief. To evaluate the efficacy and safety of a new topical treatment for moderate-to-severe tinea pedis. Fifty patients suffering from tinea pedis were treated in two stages: the ...
Lo Yuan-Hsin - - 2010
Vitiligo is a common acquired idiopathic hypomelanotic disorder characterized by circumscribed depigmented maculae. The conventional treatments are limited by their inconsistent and incomplete responses, relapse rate, inconvenience to apply, side-effects and especially long-term effects. The aim of the present study was to determine the efficacy and safety of topical tacrolimus ...
Billen Frédéric - - 2010
This study evaluated the effect of 1% bifonazole cream in the treatment of canine sino-nasal aspergillosis (SNA). The cream was instilled through perendoscopically placed catheters into the frontal sinuses and was used either as single therapy after debridement (DC) or as adjunctive therapy after 2% enilconazole infusion (DEC). Twelve dogs ...
Barolet Daniel - - 2010
BACKGROUND AND OBJECTIVE: An alternative approach in the treatment of acne vulgaris is photodynamic therapy (PDT) that uses light and aminolevulinic acid (ALA)-induced protoporphyrin IX (PpIX) production to eradicate Propionibacterium acnes found in acne lesions. PpIX formation is dependent on ALA percutaneaous penetration. In this study, to enhance ALA penetration ...
Ablon Glynis - - 2010
BACKGROUND AND OBJECTIVES: Psoriasis is one of the major problems facing dermatologists worldwide. Planar arrays of light-emitting diodes (LEDs) have recently attracted attention in the treatment of difficult dermatological entities, 830 nm in near infrared (near-IR) and 633 nm in visible red. This study was designed to assess the efficacy ...
Hallaji Zahra Z Department of Dermatology, Razi Hospital, Tehran University of Medical Sciences, Tehran, - - 2010
Narrowband ultraviolet B (NB-UVB) phototherapy is an effective treatment for psoriasis. To compare the effects of three and five times weekly NB-UVB phototherapy in the treatment of chronic plaque psoriasis. Sixty-five patients with chronic plaque psoriasis were allocated to receive three or five times weekly NB-UVB, starting at low dose. ...
Oram Yasemin - - 2010
BACKGROUND: The treatment options for nail psoriasis have been limited, and the management of nail psoriasis has been challenging for physicians. OBJECTIVES: To evaluate the effect of pulsed dye laser (PDL) in the treatment of nail psoriasis. METHODS: Psoriatic nails of five patients were treated using PDL (595 nm) once ...
el-Mofty Medhat - - 2011
Conventional therapy of extensive psoriasis is effective but has complications. Biologics are safer but expensive. To assess the efficacy of sulfasalazine and pentoxifylline, which have TNF antagonizing and anti-proliferative action in the treatment of psoriasis. In this randomized controlled trial, 32 patients with extensive psoriasis were divided into four groups: ...
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