Search Results
Results 501 - 550 of 929
< 6 7 8 9 10 11 12 13 14 15 16 >
White Ian R - - 2005
In randomized trials with departures from allocated treatment, intention-to-treat analysis is important but not always sufficient. The most common supplement to intention-to-treat analysis is per-protocol analysis, whose assumption of comparability between different nonrandomized groups is often implausible. Randomization-based methods avoid making this assumption and are preferable. Situations where intention-to-treat analysis ...
Kaas R - - 2005
Randomized clinical trials (RCT) are the best way to define optimal treatment, but the accrual rates for hardly any trials have been reported. We analyzed retrospectively the participation of patients in eight phase III multicenter RTCs. Out of a total of 738 patients treated in a single institution for operable ...
Lankester, K.
The first fisheries agreement between the European Community and Angola was signed in 1987. Protocols were renewed normally every two years. In July 2002 the European Commission announced the latest agreement with Angola, from here on the “Agreement”. It will last for two years: August 2002 – August 2004. The ...
Coad D Stephen - - 2005
A fully sequential procedure is proposed for comparing K > or =3 treatments with immediate binary responses. The procedure uses an adaptive urn design to randomize patients to the treatments and stopping rules are incorporated for eliminating less promising treatments. Simulation is used to assess the performance of the procedure ...
Zhou Yong - - 2005
AIM: To assess the effectiveness and safety of perioperative growth hormone (GH) in patients undergoing abdominal surgery. METHODS: We searched the following electronic databases: MEDLINE, EMBASE, the Cochrane Controlled Trials Register, Chinese Bio-medicine Database. The search was undertaken in February 2003. No language restrictions were applied. Randomized controlled trials (RCT) ...
Devereaux P J - - 2005
To determine the effect of perioperative beta blocker treatment in patients having non-cardiac surgery. Systematic review and meta-analysis. Seven search strategies, including searching two bibliographic databases and hand searching seven medical journals. STUDY SELECTION AND OUTCOMES: We included randomised controlled trials that evaluated beta blocker treatment in patients having non-cardiac ...
DePalma Michael J - - 2005
OBJECTIVE: To critically review the best available trials of the utility of transforaminal epidural steroid injections (TFESIs) or selective nerve root blocks (SNRBs) to treat lumbosacral radiculopathy. DATA SOURCES: MEDLINE (PubMed, Ovid, MDConsult), EMBASE, and the Cochrane database. Databases were searched from inception through 2003. STUDY SELECTION: A database search ...
Bullock R - - 2005
The cholinesterase inhibitors (ChE-Is)--rivastigmine, donepezil and galantamine--demonstrated efficacy in large, 6-month, double-blind, placebo-controlled trials, and are widely used for the symptomatic treatment of patients with mild-to-moderate Alzheimer's disease (AD). Over the past few years, data have emerged, suggesting that these agents may have long-term benefits. These data have been summarized ...
Lévy Vincent - - 2005
Long-term results of high-dose therapy followed by autologous stem cell transplantation (HDT-ASCT) as the first-line treatment for patients with myeloma are still poorly reported. To gain further insight in the long-term benefits of first-line HDT-ASCT compared with conventional therapy in myeloma, we performed a meta-analysis of individual patient data. We ...
de Wit Deric - - 2005
The treatment of non-infectious uveitis is often a challenging experience for both the patient and the treating physician. The use of traditional forms of treatment is restricted by limited effectiveness and considerable side effects. This review examines the current trends in therapy and the emerging new classes of therapeutic agents ...
Herbertson R - - 2005
With the development of an integrated treatment approach, the cure rate and survival of patients with Hodgkin Lymphoma (HL) is now high. Treatment tailored to stage, using chemotherapy, with or without involved field radiotherapy is the standard of care. Paediatric oncologists have been developing treatment regimens to maximise cure rate ...
Avansino Jeffrey R - - 2005
OBJECTIVE: The optimal treatment of children with empyema remains controversial. The purpose of this review was to compare reported results of nonoperative and primary operative therapy for the treatment of pediatric empyema. METHODS: A systematic comprehensive review of the scientific literature was conducted with the PubMed (National Library of Medicine) ...
- - 2005
(1) Evidence that the Cox-2 inhibitors have severe cardiovascular adverse effects continues to accumulate, including an increase in overall mortality in several trials of rofecoxib. (2) Yet regulatory agencies on both sides of the Atlantic have so far only taken half-measures, issuing new contraindications and warnings that complicate matters for ...
Dingli David - - 2005
Thrombocytosis is a common clinical problem and it represents either a primary myeloid disorder (a clonal process) or a reactive phenomenon. While reactive thrombocytosis is often inconsequential, clonal thrombocytosis may require cytoreductive therapy to prevent thrombohemorrhagic complications. In this regard, a controlled clinical trial has previously demonstrated the efficacy of ...
Amadori S - - 2005
BACKGROUND: Arsenic trioxide delivers high rates of complete clinical remission in patients with relapsed/refractory acute promyelocytic leukaemia (APL), and is associated with high rates of molecular remission as indicated by PCR negativity for the PML-RARalpha gene. OBJECTIVE: Mitochondria are considered to be the primary intracellular target of arsenic trioxide, and ...
Garde J - - 2005
BACKGROUND: Sensitivity to Salsola kali is a frequent cause of allergic respiratory disease in various regions of Spain. However, there are very few articles in which this allergen has been studied. METHODS AND RESULTS: In order to evaluate the tolerance of this extract, a prospective study has been performed. This ...
Soares Heloisa P - - 2005
The superiority of innovative over standard treatments is not known. To describe accurately the outcomes of innovations that are tested in randomized controlled trials (RCTs) 3 factors have to be considered: publication rate, quality of trials, and the choice of the adequate comparator intervention. To determine the success rate of ...
Ancoli-Israel Sonia - - 2005
BACKGROUND AND PURPOSE: Insomnia is a common problem that increases with age and can last months to years. While substantial data establish the efficacy and safety of short-acting hypnotic therapy for the management of short-term insomnia using benzodiazepines receptor agonists (BzRAs), there are few studies on the continued efficacy and ...
Weber Klaus - - 2005
BACKGROUND: Presently, problems exist with the rationale of oral therapy and the nature and indication of topical and accompanying treatment of perioral dermatitis. OBJECTIVE: Providing the basis to overcome these problems by a quality evaluation of treatment reports and assessment of the consistency of treatment experience. METHODS: Sources were Medline ...
Deery Chris - - 2005
DATA SOURCES: Medline Ovid Library, the Cochrane Library, PubMed, Embase, Science Citation Index (SCI) and System for Information on Grey Literature in Europe (SIGLE). STUDY SELECTION: Reviews, full reports, or research abstracts of prospective, retrospective, comparative, and/or radiographic studies were included, while case reports and letters were excluded. DATA EXTRACTION ...
Lipscomb Bailey - - 2005
We describe a randomized controlled trial of an investigational spinal implant. The investigational device has an obvious benefit in comparison with control in that it precludes the need for harvesting bone graft and the pain and morbidity associated with it. Therefore, the principal comparison is one of noninferiority. The primary ...
Ghani Fazal - - 2005
DATA SOURCES: The Cochrane Oral Health Group Trials Register, Cochrane Central Register of Controlled Trials, Medline, OLDMedline, Embase, Zetoc (Zetoc provides access to the British Library's electronic table of contents of approx. 20,000 current journals and 16,000 conference proceedings published per year. The database covers 1993 to date and is ...
Sadowsky Carl H - - 2005
Background: Transitioning patients between cholinesterase inhibitors was thought to require a washout period to avoid cholinergic toxicity; however, evidence suggests that abrupt discontinuation of donepezil may lead to cognitive decline. We evaluated the safety and tolerability of an immediate switch from donepezil to rivastigmine.Method: This is an analysis of the ...
Flores-Mir Carlos - - 2005
DATA SOURCES: PubMed and the Cochrane Controlled Clinical Trials Register were searched. Reference lists from retrieved articles were also searched by hand for additional studies. STUDY SELECTION: For inclusion, an article had to satisfy the following criteria: cases in primary and early mixed dentition with unilateral posterior crossbite; be a ...
Berger Robert L - - 2005
BACKGROUND: Observational studies have suggested that lung volume reduction surgery (LVRS) is superior to optimal medical therapy for selected subsets of patients with advanced emphysema. Randomized clinical trials (RCTs) with the exception of the National Emphysema Treatment Trial (NETT), failed to enroll a sufficient number of patients to provide clinicians ...
Chow Shein-Chung - - 2005
In recent years, the use of adaptive methods in clinical development based on accrued data has become very popular due to its flexibility in modifying trial procedures and/or statistical procedures of on-going clinical trials. However, it is a concern that the actual patient population after the modifications could deviate from ...
Abraham P - - 2005
Antithyroid drugs are widely used in the therapy of hyperthyroidism. There are wide variations in the dose, regimen or duration of treatment used by health professionals. To assess the effects of dose, regimen and duration of antithyroid drug therapy for Graves' hyperthyroidism. We searched the Cochrane Central Register of Controlled ...
Clarke J A - - 2005
Various types of traction are used in the treatment of low-back pain (LBP), often in conjunction with other treatments. To determine the effectiveness of traction in the management of LBP. We searched The Cochrane Library 2004, Issue 4, MEDLINE, EMBASE, and CINAHL to November 2004, references in relevant reviews, and ...
Wood-Baker R R - - 2005
COPD is a common condition, mainly related to smoking. The burden of the disease is increasing and it is projected to rank fifth in 2020 for the world-wide burden of disease. Acute exacerbations of COPD, usually related to superimposed infection occur commonly and systemic corticosteroids are widely used in their ...
Bloomfield P - - 2005
Urinary tract infection (UTI) is one of the most common bacterial infection in infants. The most severe form of UTI is acute pyelonephritis, which results in significant acute morbidity and may cause permanent renal damage. Published guidelines recommend treatment of acute pyelonephritis initially with intravenous (IV) therapy followed by oral ...
Fedorowicz Z - - 2005
Age-related cataract accounts for more than 40% of cases of blindness in the world with the majority of people who are blind from cataract found in the developing world. With the increased number of people with cataract there is an urgent need for cataract surgery to be made available as ...
van Dalen E C - - 2005
Anthracyclines are among the most effective chemotherapeutic agents in the treatment of numerous malignancies. Unfortunately, their use is limited by a dose-dependent cardiotoxicity. In an effort to prevent this cardiotoxicity, different cardioprotective agents have been studied. The objective of this review was to assess the efficacy of different cardioprotective agents ...
Altunaiji S - - 2005
Whooping cough is a highly contagious disease. Infants are the population at highest risk of severe disease and death. Erythromycin for 14 days is recommended for treatment and contact prophylaxis but this regime is considered inconvenient and prolonged. The value of contact prophylaxis is uncertain. To study the benefits and ...
Sutton A F - - 2005
When constructing complete dentures for edentulous patients, ultimately patient satisfaction is key. Complete dentures can be produced with different types of occlusal schemes (chewing surfaces) and it is widely accepted that the occlusal scheme for complete dentures has a direct influence upon their success. To assess the relative effectiveness of ...
Blitz M - - 2005
Asthma exacerbations can be frequent and range in severity from relatively mild to status asthmaticus. The use of magnesium sulfate (MgSO4) is one of numerous treatment options available during acute exacerbations. While the efficacy of intravenous MgSO4 has been demonstrated, little is known about inhaled MgSO4. To examine the efficacy ...
Holdgate A - - 2005
Renal colic is a common cause of acute severe pain. Both opioids and nonsteroidal anti-inflammatory drugs (NSAIDs) are recommended for treatment, but the relative efficacy of these drugs is uncertain. To examine the benefits and disadvantages of NSAIDs and opioids for the management of pain in acute renal colic. We ...
Oates-Whitehead R M - - 2005
Acute bacterial meningitis remains a disease with high mortality and morbidity rates. However, with prompt and adequate antimicrobial and supportive treatment, the chances for survival have improved, especially in infants and children. Careful management of fluid and electrolyte balance is an important supportive therapy. Both over and under hydration are ...
van Dongen C J - - 2005
In the initial treatment of venous thromboembolism (VTE) low molecular weight heparin (LMWH) is administered once or twice daily. A once daily treatment regimen is more convenient for the patient and may optimise home treatment. However, it is not clear whether a once daily treatment regimen is as safe and ...
Mayet S S Institute of Psychiatry, 4 Windsor Walk, London, UK. - - 2005
Substance dependence is a major social and public health problem; therefore it is a priority to develop effective treatments. The treatment of opioid dependence is complex. Previous Cochrane reviews have explored the efficacy of pharmacotherapy for opiate dependence. This current review focuses on the role of psychosocial interventions alone for ...
Shah P S PS Department of Paediatrics and Department of Health Policy, Management and Evaluation, University of Toronto, Rm 775A, 600 University Avenue, Toronto, Ontario, Canada, M5G 1XB. - - 2005
Acute hypoxemic respiratory failure (AHRF) is an important cause of mortality and morbidity in the pediatric age group. Positive pressure ventilation is currently the standard of care, though is known to be associated with complications. Continuous negative extrathoracic pressure ventilation (CNEP) or continuous positive airway pressure ventilation delivered via non-invasive ...
Cohen-Kerem Raanan - - 2004
OBJECTIVES: To systematically review the published experience on intratympanic gentamicin treatment for intractable Menière's disease. STUDY DESIGN: Meta-analysis using a random effect model. METHODS: A comprehensive literature search was performed for articles using intratympanic gentamicin as a sole treatment modality with reporting of results according to the American Academy of ...
Bucher Pascal - - 2004
HYPOTHESIS: There is little scientific evidence to support the routine practice of mechanical bowel preparation (MBP) before elective colorectal surgery in order to minimize the risk of postoperative septic complications. DATA SOURCES: Trials were retrieved using a MEDLINE search followed by a manual search of the bibliographic information in select ...
Wolfe F - - 2004
OBJECTIVE: Results of randomised clinical trials (RCTs) appear to differ from results of observational studies. This paper explores differences in methodology, interpretation and presentation of results that elucidate these differences. METHOD: We identified patients who completed a survey questionnaire during the period January 1998 through December 1998 and also completed ...
Stepniewska Kasia - - 2004
To determine the optimum duration of follow-up for the assessment of drug efficacy against Plasmodium falciparum malaria, 96 trial arms from randomized controlled trials (RCTs) with follow-up of 28 days or longer that were conducted between 1990 and 2003 were analyzed. These trials enrolled 13,772 patients, and participating patients comprised ...
Vincent Jean-Louis - - 2004
OBJECTIVE: To determine the effect of albumin administration on morbidity in acutely ill hospitalized patients. DATA SOURCE: Computer searches of MEDLINE, EMBASE, and the Cochrane Library; hand searches of journals and Index Medicus; inquiries with investigators and fluid product suppliers; and examination of reference lists. No language or time period ...
Bath-Hextall Fiona - - 2004
To assess the effects of treatments for basal cell carcinoma. Systematic review of randomised controlled trials. Recurrence of basal cell carcinoma at three years or beyond, assessed clinically. Randomised controlled trials of interventions for histologically confirmed basal cell carcinoma (published and unpublished material; no language restrictions). 25 studies were identified, ...
Juan M. Guayasamin
The anuran genus Eleutherodactylus occurs in Central and South America, as well as the West Indies, and comprises nearly 700 recognized species. The diversity of Eleutherodactylus makes it difficult to study the genus as a whole; as a consequence, several authors have divided the genus in phenetic species groups. This ...
Keith Samuel J - - 2004
OBJECTIVE: It is now generally accepted that the use of second-generation, or atypical, antipsychotics for schizophrenia represents an advance over conventional antipsychotic agents. However, adherence continues to be a problem, as with other medications for chronic disorders. Long-acting formulations of conventional antipsychotics partly address adherence problems, but their use is ...
IOTC
Distant water fishing nations (DWFN) began longlining for tuna in the Western Indian Ocean (WIO) in the early 1950s, initiated by the Japanese soon followed by the Taiwanese (1954) and Koreans (1960). Large scale industrial purse seining began in 1983 when the French and Spanish fleets moved into the Western ...
Annane Djillali - - 2004
To assess the effects of corticosteroids on mortality in patients with severe sepsis and septic shock. Randomised and quasi-randomised trials of corticosteroids versus placebo (or supportive treatment alone) retrieved from the Cochrane infectious diseases group's trials register, the Cochrane central register of controlled trials, Medline, Embase, and LILACS. Two pairs ...
< 6 7 8 9 10 11 12 13 14 15 16 >